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Featured Research Papers

Authors of this month's paper.
Authors of this month's paper.

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February's Featured Paper!

PIncreased vulnerability to cocaine in mice lacking dopamine D3 receptors

PNAS Published online before print, October 8, 2012, doi:10.1073/pnas.1205297109

Rui Song, Hai-Ying Zhang, Xia Li, Guo-Hua Bi, Eliot L. Gardner, and Zheng-Xiong Xi

Neuroimaging studies using positron emission tomography suggest that reduced dopamine D2 receptor availability in the neostriatum is associated with increased vulnerability to drug addiction in humans and experimental animals. The role of D3 receptors (D3Rs) in the neurobiology of addiction remains unclear, however. Herewereport that D3R KO (D3 -/-) mice display enhanced cocaine self-administration and enhanced motivation for cocaine-taking and cocaine-seeking behavior. This increased vulnerability to cocaine is accompanied by decreased dopamine response to cocaine secondary to increased basal levels of extracellular dopamine in the nucleus accumbens, suggesting a compensatory response to decreased cocaine reward in D3 -/- mice. In addition, D3 -/-| mice also display up-regulation of dopamine transporters in the striatum, suggesting a neuroadaptative attempt to normalize elevated basal extracellular dopamine. These findings suggest that D3R deletion increases vulnerability to cocaine, and that reducedD3R availability in the brainmay constitute a risk factor for the development of cocaine addiction.

You can read more about this paper at the website for PNAS.

January's Featured Paper!

Powerful Cocaine-Like Actions of 3,4-Methylenedioxypyrovalerone (MDPV), a Principal Constituent of Psychoactive ‘Bath Salts’ Products

Neuropsychopharmacology advance online publication, 17 October 2012; doi:10.1038/npp.2012.204

Michael H Baumann, John S Partilla, Kurt R Lehner, Eric B Thorndike Alexander F Hoffman, Marion Holy, Richard B Rothman, Steven R Goldberg, Carl R Lupica, Harald H Sitte, Simon D Brandt, Srihari R Tella, Nicholas V Cozzi, Charles W Schindler

You can read more about this paper at the website for Neuropsychopharmacology.

December's Featured Paper!

R-Modafinil (Armodafinil): A Unique Dopamine Uptake Inhibitor and Potential Medication for Psychostimulant Abuse

Biol. Psych., 2012;72:405–413

Claus J. Loland, Maddalena Mereu, Oluyomi M. Okunola, Jianjing Cao, Thomas E. Prisinzano, Sonia Mazier, Theresa Kopajtic, Lei Shi, Jonathan L. Katz, Gianluigi Tanda, Amy Hauck Newman

You can read more about this paper at the website for Science Direct.

November's Featured Paper!

Antagonism of Sigma-1 Receptors Blocks Compulsive-Like Eating

Neuropsychopharmacology, 2012 Nov;37(12):2593-604. doi: 10.1038/npp.2012.89

Pietro Cottone, Xiaofan Wang, Jin Won Park, Marta Valenza, Angelo Blasio, Jina Kwak, Malliga R Iyer, Luca Steardo, Kenner C Rice, Teruo Hayashi, and Valentina Sabino

You can read more about this paper at the website for Neuropsychopharmacology.

October's Featured Paper!

Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

J. Med. Chem., 2012, 55 (15), pp 6689–6699 | DOI: 10.1021/jm300482h

Amy Hauck Newman, Thijs Beuming, Ashwini K. Banala, Prashant Donthamsetti, Katherine Pongetti, Alex LaBounty, Benjamin Levy, Jianjing Cao, Mayako Michino, Robert R. Luedtke, Jonathan A. Javitch, and Lei Shi

You can read more about this paper at the website for the Journal of Medicinal Chemistry.

Archives of Prior Hot Papers

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