The Manuscript Division holds the papers of 23 of America's presidents. These extend in time from George Washington to Calvin Coolidge and include in all about two million manuscripts. The papers of the following presidents are included:
| President | Dates in Office | Span Dates of the Collection | Bulk Dates of the Collection |
|---|---|---|---|
| George Washington | 1789-1797 | 1592-1937 | 1748-1799 |
| Thomas Jefferson | 1801-1809 | 1743-1826 | 1775-1826 |
| James Madison | 1809-1817 | 1723-1859 | 1771-1836 |
| James Monroe | 1817-1825 | 1778-1831 | 1795-1822 |
| Andrew Jackson | 1825-1837 | 1775-1860 | 1785-1845 |
| Martin Van Buren | 1837-1841 | 1787-1910 | 1820-1850 |
| William H. Harrison | 1841 | 1734-1939 | 1796-1841 |
| John Tyler | 1841-1845 | 1691-1918 | ? |
| James K. Polk | 1845-1849 | 1775-1891 | 1830-1849 |
| Zachary Taylor | 1849-1850 | 1814-1931 | 1849-1861 |
| Franklin Pierce | 1853-1857 | 1820-1869 | 1853-1856 |
| Abraham Lincoln | 1861-1865 | 1833-1916 | 1858-1865 |
| Andrew Johnson | 1865-1869 | 1814-1947 | 1864-1869 |
| Ulysses S. Grant | 1869-1877 | 1843-1969 | 1843-1908 |
| James A. Garfield | 1881 | 1831-1881 | 1850-1881 |
| Chester A. Arthur | 1881-1885 | 1843-1960 | 1870-1888 |
| Grover Cleveland | 1885-1889 | 1859-1945 | 1885-1908 |
| Benjamin Harrison | 1889-1893 | 1787-1945 | 1787-1892 |
| William McKinley | 1897-1901 | 1847-1901 | 1897-1901 |
| Theodore Roosevelt | 1901-1909 | 1759-1920 | 1901-1918 |
| William H. Taft | 1909-1913 | 1784-1941 | 1900-1930 |
| Woodrow Wilson | 1913-1921 | 1850-1924 | 1910-1919 |
| Calvin Coolidge | 1923-1929 | 1915-1932 | 1923-1927 |