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U.S. National Institutes of Health
Cancer Diagnosis Program Cancer Imaging Program Cancer Therapy Evaluation Program Developmental Therapeutics Program Radiation Research Program Translational Research Program Biometric Research Branch Office of Cancer Complementary and Alternative Medicine
Last Updated: 04/25/2012

PARTNERSHIPS AND COLLABORATIONS

Industry Collaborations

CTEP is in a unique position to facilitate nonclinical and clinical studies involving combinations of investigational anticancer treatments, especially when the agents are developed by more than one pharmaceutical company. At present, CTEP has 102 active INDs, with approximately two-thirds of these being co-developed with members of industry.

CTEP Collaborators and Agents

COLLABORATORS AGENT NAMES
Abbott Laboratories ABT-888 (NSC 737664)
Amgen Inc AMG-386 (NSC 751173)
Arqule Inc ARQ-197 (NSC 750832)
Ascalon International Fenretinide (NSC 374551)
Ascenta Therapeutics Inc (R)-(-)-Gossypol acetic acid (Ascenta's AT-101) (NSC 726190)
Astellas Inc OSI-906
Astex Therapeutics Ltd AT13387 (NSC 749712)
AstraZeneca Pharmaceuticals AZD0530 (NSC 735464)
AZD2171 (cediranib; Recentin™) (NSC 732208)
AZD6244 (NSC 741078)
Fostamatinib (R788) (NSC 745942)
Gefitinib (ZD1839, Iressa) (NSC 715055)
Bayer Corporation BAY 43-9006 tosylate (BAY 54-9085; sorafenib tosylate) (NSC 724772)
Bristol-Myers Squibb Company 17-AAG (NSC 330507) **
17-DMAG (NSC 707545) **
BMS 247550 (ixabepilone, Ixempra) (NSC 710428)
BMS-354825 (dasatinib, Sprycel) (NSC 732517)
Celgene Corporation Azacitidine (NSC 102816)
CC-5013 (lenalidomide, Revlimid) (NSC 703813)
FK228 (Depsipeptide; Romidepsin) (NSC 630176)
Thalidomide (Thalomid) (NSC 66847)
Eisai Inc Decitabine (5-aza-2'-deoxycytidine) (NSC 127716)
E7389 (Halichondrin B analog) (NSC 707389)
GeminX Pharmaceuticals Inc Obatoclax mesylate (GX15-070MS) (NSC 729280)
Genentech Inc Bevacizumab (rhuMAb VEGF, Avastin) (NSC 704865)
GDC-0449 (NSC 747691) ***
Trastuzumab (Herceptin) (NSC 688097)
Genzyme Corporation Alemtuzumab (Campath) (NSC 715969)
GlaxoSmithKline Inc 506U78 (NSC 686673)
GW572016 (lapatinib) (NSC 727989)
GW786034 (pazopanib) (NSC 737754)
Imclone Systems Inc IMC-A12 (NSC 742460)
Johnson & Johnson Inc R115777 (tipifarnib, Zarnestra) (NSC 702818)
Keryx Biopharmaceuticals Perifosine (NSC 639966)
Kyowa Hakko Kogyo Inc UCN-01 (NSC 638850)
Medarex Inc MDX-010 (MDX-CTLA4; Hybridoma-derived and Transfectoma-derived) (NSC 732442)
Merck and Company Inc MK-2206 (NSC 749607)
Vorinostat (suberoylanilide hydroxamic acid; SAHA) (NSC 701852)
Merck KgaA EMD 121974 (Cilengitide) (NSC 707544)
Millennium Pharmaceuticals Inc MLN 518 (NSC 726292)
MLN-8237 (NSC 747888)
Millennium, a Takeda Company Bortezomib (PS-341; Velcade) (NSC 681239)
Nanotherapeutics Inc Triapine (NSC 663249)
National Cancer Institute FAU (NSC 678515)
IPdR (NSC 726188)
O-6-Benzylguanine (NSC 637039)
NewLinkGenetics Corporation 1-Methyl-[D]-tryptophan (NSC 721782)
Novartis Pharmaceuticals Corporation STI571 (imatinib, Gleevec) (NSC 716051)
Oncolytics Biotech Inc Reolysin (NSC 729968)
OSI Pharmaceuticals Inc Erlotinib (OSI-774; Tarceva) (NSC 718781)
Pfizer Inc CCI-779 (temsirolimus, Torisel) (NSC 683864)
Sunitinib malate (SU011248 L-malate; Sutent) (NSC 736511)
Roche Pharmaceuticals RO4929097 (NSC 749225)
Sanofi Aventis Corporation Flavopiridol (alvocidib) (NSC 649890)
Oxaliplatin (Eloxatin) (NSC 266046)
VEGF-Trap (aflibercept) (NSC 724770)
Schering-Plough Corporation SCH727965 (NSC 747135)
Spirogen Ltd SJG-136 (NSC 694501)
Syndax Pharmaceuticals Inc Entinostat (MS-275, SNDX-275) (NSC 706995)
Tigris Pharmaceuticals Inc AFP464 (aminoflavone prodrug) (NSC 710464)
TopoTarget A/S Belinostat (PXD 101) (NSC 726630)
Tracon Pharmaceuticals Inc TRC-105 (NSC 754227)
United Therapeutics Corporation ch 14.18 (NSC 623408)
Total: 41 Total: 63

** supplying agent for non-clinical work

As of May 2011

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