Dr. Chen received his B.S. in 1993 and M.S. in 1996 from Nanjing University, China. He then moved to the states and obtained his Ph.D. in chemistry from the University of Idaho in 1999 under the supervision of Professor Chien M. Wai. After two quick postdoctoral programs at Syracuse University (under the mentorship of Dr. Jon Zubieta) and Washington University in St. Louis (supervised by Professor Michael J. Welch), Dr. Chen joined the University of Southern California as an Assistant Professor of Radiology. He then moved to Stanford University in 2004 to help build the Molecular Imaging Program at Stanford (MIPS) under the directorship of Professor Sanjiv Sam Gambhir, and was promoted to Associate Professor in 2008. In the summer of 2009, he joined the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) as a tenured Senior Investigator. Dr. Chen also holds a joint appointment with the NIH Clinical Center.

2012

Ghanouni P, Behera D, Xie J, Chen X, Moseley M, Biswal S
In vivo USPIO magnetic resonance imaging shows that minocycline mitigates macrophage recruitment to a peripheral nerve injury.
Mol Pain, 2012 Jun 28;8(1):49 [Epub ahead of print]

Huang P, Lin J, Wang X, Wang Z, Zhang C, He M, Wang K, Chen F, Li Z, Shen G, Cui D, Chen X
Light-Triggered Theranostics Based on Photosensitizer-Conjugated Carbon Dots for Simultaneous Enhanced-Fluorescence Imaging and Photodynamic Therapy.
Adv Mater, 2012 Jun 21; [Epub ahead of print]

Swierczewska M, Choi KY, Mertz EL, Huang X, Zhang F, Zhu L, Yoon HY, Park JH, Bhirde A, Lee S, Chen X
A Facile, One-Step Nanocarbon Functionalization for Biomedical Applications.
Nano Lett, 2012 Jun 20; [Epub ahead of print]

Jang ES, Shin JH, Ren G, Park MJ, Cheng K, Chen X, Wu JC, Sunwoo JB, Cheng Z
The manipulation of natural killer cells to target tumor sites using magnetic nanoparticles.
Biomaterials, 2012 Aug;33(22):5584-92

Zhang F, Huang X, Zhu L, Guo N, Niu G, Swierczewska M, Lee S, Xu H, Wang AY, Mohamedali KA, Rosenblum MG, Lu G, Chen X
Noninvasive monitoring of orthotopic glioblastoma therapy response using RGD-conjugated iron oxide nanoparticles.
Biomaterials, 2012 Jul;33(21):5414-22

Bu L, Xie J, Chen K, Huang J, Aguilar ZP, Wang A, Sun KW, Chua MS, So S, Cheng Z, Eden HS, Shen B, Chen X
Assessment and comparison of magnetic nanoparticles as MRI contrast agents in a rodent model of human hepatocellular carcinoma.
Contrast Media Mol Imaging, 2012 Jul;7(4):363-72

Chen X, Swierczewska M, Choi KY, Mertz E, Huang X, Zhang F, Zhu L, Park JH, Bhirde AA, Leikin S, Lee S
A Facile, One-Step Nanocarbon Functionalization for Biomedical Applications.
Nano Lett, 2012 Jun 13; [Epub ahead of print]

Choi KY, Jeon EJ, Yoon HY, Lee BS, Na JH, Min KH, Kim SY, Myung SJ, Lee S, Chen X, Kwon IC, Choi K, Jeong SY, Kim K, Park JH
Theranostic nanoparticles based on PEGylated hyaluronic acid for the diagnosis, therapy and monitoring of colon cancer.
Biomaterials, 2012 Jun 9; [Epub ahead of print]

Zhang F, Niu G, Lin X, Jacobson O, Ma Y, Eden HS, He Y, Lu G, Chen X
Imaging tumor-induced sentinel lymph node lymphangiogenesis with LyP-1 peptide.
Amino Acids, 2012 Jun;42(6):2343-51

Huang X, Zhang F, Lee S, Swierczewska M, Kiesewetter DO, Lang L, Zhang G, Zhu L, Gao H, Choi HS, Niu G, Chen X
Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes.
Biomaterials, 2012 Jun;33(17):4370-8

Srivastava S, Kashiwaya Y, King MT, Baxa U, Tam J, Niu G, Chen X, Clarke K, Veech RL
Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet.
FASEB J, 2012 Jun;26(6):2351-62

Zhu L, Huang X, Choi KY, Ma Y, Zhang F, Liu G, Lee S, Chen X
Real-time monitoring of caspase cascade activation in living cells.
J Control Release, 2012 Jun 1; [Epub ahead of print]

de la Zerda A, Bodapati S, Teed R, May SY, Tabakman SM, Liu Z, Khuri-Yakub BT, Chen X, Dai H, Gambhir SS
Family of Enhanced Photoacoustic Imaging Agents for High-Sensitivity and Multiplexing Studies in Living Mice.
ACS Nano, 2012 May 31; [Epub ahead of print]

Zhang F, Zhu L, Huang X, Niu G, Chen X
Differentiation of Reactive and Tumor Metastatic Lymph Nodes with Diffusion-weighted and SPIO-Enhanced MRI.
Mol Imaging Biol, 2012 May 16; [Epub ahead of print]

Niu G, Murad YM, Gao H, Hu S, Guo N, Jacobson O, Nguyen TD, Zhang J, Chen X
Molecular targeting of CEACAM6 using antibody probes of different sizes.
J Control Release, 2012 May 5;161(1):18-24 [Epub ahead of print]

Bhirde AA, Kapoor A, Liu G, Iglesias-Bartolome R, Jin A, Zhang G, Xing R, Lee S, Leapman RD, Gutkind JS, Chen X
Nuclear Mapping of Nanodrug Delivery Systems in Dynamic Cellular Environments.
ACS Nano, 2012 May 2; [Epub ahead of print]

Zhang XX, Eden HS, Chen X
Peptides in cancer nanomedicine: drug carriers, targeting ligands and protease substrates.
J Control Release, 2012 Apr 10;159(1):2-13

Swierczewska M, Liu G, Lee S, Chen X
High-sensitivity nanosensors for biomarker detection.
Chem Soc Rev, 2012 Apr 7;41(7):2641-55

Chen K, Yap LP, Park R, Hui X, Wu K, Fan D, Chen X, Conti PS
A Cy5.5-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living mice.
Amino Acids, 2012 Apr;42(4):1329-37

Gao H, Lang L, Guo N, Cao F, Quan Q, Hu S, Kiesewetter DO, Niu G, Chen X
PET imaging of angiogenesis after myocardial infarction/reperfusion using a one-step labeled integrin-targeted tracer 18F-AlF-NOTA-PRGD2.
Eur J Nucl Med Mol Imaging, 2012 Apr;39(4):683-92

Shibusawa Y, Yanagida A, Ogihara A, Ma Y, Chen X, Ito Y
Separation of nucleobases and their derivatives with organic-high ionic strength aqueous phase systems by spiral high-speed counter-current chromatography.
J Chromatogr B Analyt Technol Biomed Life Sci, 2012 Apr 1;891-892:94-7

Jackson AB, Nanda PK, Rold TL, Sieckman GL, Szczodroski AF, Hoffman TJ, Chen X, Smith CJ
64Cu-NO2A-RGD-Glu-6-Ahx-BBN(7-14)NH2: a heterodimeric targeting vector for positron emission tomography imaging of prostate cancer.
Nucl Med Biol, 2012 Apr;39(3):377-87

Guo N, Lang L, Gao H, Niu G, Kiesewetter DO, Xie Q, Chen X
Quantitative Analysis and Parametric Imaging of (18)F-Labeled Monomeric and Dimeric RGD Peptides Using Compartment Model.
Mol Imaging Biol, 2012 Mar 22; [Epub ahead of print]

Lee I, Yoon KY, Kang CM, Lin X, Chen X, Kim JY, Kim SM, Ryu EK, Choe YS
Evaluation of the angiogenesis inhibitor KR-31831 in SKOV-3 tumor-bearing mice using (64)Cu-DOTA-VEGF(121) and microPET.
Nucl Med Biol, 2012 Mar 9; [Epub ahead of print]

Hu S, Kiesewetter DO, Zhu L, Guo N, Gao H, Liu G, Hida N, Lang L, Niu G, Chen X
Longitudinal PET Imaging of Doxorubicin-Induced Cell Death with (18)F-Annexin V.
Mol Imaging Biol, 2012 Mar 6; [Epub ahead of print]

Kiesewetter DO, Gao H, Ma Y, Niu G, Quan Q, Guo N, Chen X
18F-radiolabeled analogs of exendin-4 for PET imaging of GLP-1 in insulinoma.
Eur J Nucl Med Mol Imaging, 2012 Mar;39(3):463-73

Ma Y, Yang M, Gao H, Niu G, Yan Y, Lang L, Kiesewetter DO, Chen X
Evaluation of fluorine-labeled gastrin-releasing peptide receptor (GRPR) agonists and antagonists by LC/MS.
Amino Acids, 2012 Feb 22; [Epub ahead of print]

Huang X, Swierczewska M, Choi KY, Zhu L, Bhirde A, Park J, Kim K, Xie J, Niu G, Lee KC, Lee S, Chen X
Multiplex imaging of an intracellular proteolytic cascade by using a broad-spectrum nanoquencher.
Angew Chem Int Ed Engl, 2012 Feb 13;51(7):1625-30

Li W, Niu G, Lang L, Guo N, Ma Y, Kiesewetter DO, Backer JM, Shen B, Chen X
PET imaging of EGF receptors using [18F]FBEM-EGF in a head and neck squamous cell carcinoma model.
Eur J Nucl Med Mol Imaging, 2012 Feb;39(2):300-8

Chin FT, Shen B, Liu S, Berganos RA, Chang E, Mittra E, Chen X, Gambhir SS
First experience with clinical-grade ([¹8F]FPP(RGD2): an automated multi-step radiosynthesis for clinical PET studies.
Mol Imaging Biol, 2012 Feb;14(1):88-95

Wang H, Chen X
Visualization of copper metabolism by 64CuCl2-PET.
Mol Imaging Biol, 2012 Feb;14(1):14-6

Chen K, Sun X, Niu G, Ma Y, Yap LP, Hui X, Wu K, Fan D, Conti PS, Chen X
Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature.
Mol Imaging Biol, 2012 Feb;14(1):96-105

Weiss ID, Jacobson O, Kiesewetter DO, Jacobus JP, Szajek LP, Chen X, Farber JM
Positron emission tomography imaging of tumors expressing the human chemokine receptor CXCR4 in mice with the use of 64Cu-AMD3100.
Mol Imaging Biol, 2012 Feb;14(1):106-14

Martiniova L, Cleary S, Lai EW, Kiesewetter DO, Seidel J, Dawson LF, Phillips JK, Thomasson D, Chen X, Eisenhofer G, Powers JF, Kvetnansky R, Pacak K
Usefulness of [18F]-DA and [18F]-DOPA for PET imaging in a mouse model of pheochromocytoma.
Nucl Med Biol, 2012 Feb;39(2):215-26

Jacobson O, Weiss ID, Szajek LP, Niu G, Ma Y, Kiesewetter DO, Peled A, Eden HS, Farber JM, Chen X
Improvement of CXCR4 tracer specificity for PET imaging.
J Control Release, 2012 Jan 30;157(2):216-23

Choi KY, Liu G, Lee S, Chen X
Theranostic nanoplatforms for simultaneous cancer imaging and therapy: current approaches and future perspectives.
Nanoscale, 2012 Jan 21;4(2):330-42

Liu G, Choi KY, Bhirde A, Swierczewska M, Yin J, Lee SW, Park JH, Hong JI, Xie J, Niu G, Kiesewetter DO, Lee S, Chen X
Sticky nanoparticles: a platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate.
Angew Chem Int Ed Engl, 2012 Jan 9;51(2):445-9

Liu G, Wang Z, Lee S, Ai H, Chen X
Design and fabrication of N-alkyl-polyethylenimine-stabilized iron oxide nanoclusters for gene delivery.
Methods Enzymol, 2012;509:263-76

Guo N, Lang L, Li W, Kiesewetter DO, Gao H, Niu G, Xie Q, Chen X
Quantitative Analysis and Comparison Study of [(18)F]AlF-NOTA-PRGD2, [(18)F]FPPRGD2 and [(68)Ga]Ga-NOTA-PRGD2 Using a Reference Tissue Model.
PLoS One, 2012;7(5):e37506

Wei D, Ren C, Chen X, Zhao H
The chronic protective effects of limb remote preconditioning and the underlying mechanisms involved in inflammatory factors in rat stroke.
PLoS One, 2012;7(2):e30892

Niu G, Chen X
Molecular imaging with activatable reporter systems.
Theranostics, 2012;2(4):413-23

Choi KY, Swierczewska M, Lee S, Chen X
Protease-activated drug development.
Theranostics, 2012;2(2):156-78

Chen XS
One year after a successful start of theranostics.
Theranostics, 2012;2(1):1-2

2011

Li W, Lang L, Niu G, Guo N, Ma Y, Kiesewetter DO, Shen B, Chen X
N-Succinimidyl 4-[(18)F]-fluoromethylbenzoate-labeled dimeric RGD peptide for imaging tumor integrin expression.
Amino Acids, 2011 Dec 31; [Epub ahead of print]

Lang L, Li W, Guo N, Ma Y, Zhu L, Kiesewetter DO, Shen B, Niu G, Chen X
Comparison study of [18F]FAl-NOTA-PRGD2, [18F]FPPRGD2, and [68Ga]Ga-NOTA-PRGD2 for PET imaging of U87MG tumors in mice.
Bioconjug Chem, 2011 Dec 21;22(12):2415-22

Zhu L, Zhang F, Ma Y, Liu G, Kim K, Fang X, Lee S, Chen X
In vivo optical imaging of membrane-type matrix metalloproteinase (MT-MMP) activity.
Mol Pharm, 2011 Dec 5;8(6):2331-8

Zeng Y, Liu G, Ma Y, Chen X, Ito Y
Organic high ionic strength aqueous two-phase solvent system series for separation of ultra-polar compounds by spiral high-speed counter-current chromatography.
J Chromatogr A, 2011 Dec 2;1218(48):8715-7

Jacobson O, Zhu L, Niu G, Weiss ID, Szajek LP, Ma Y, Sun X, Yan Y, Kiesewetter DO, Liu S, Chen X
MicroPET imaging of integrin avß3 expressing tumors using 89Zr-RGD peptides.
Mol Imaging Biol, 2011 Dec;13(6):1224-33

Xing R, Zhang F, Xie J, Aronova M, Zhang G, Guo N, Huang X, Sun X, Liu G, Bryant LH, Bhirde A, Liang A, Hou Y, Leapman RD, Sun S, Chen X
Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI.
Nanoscale, 2011 Dec;3(12):4943-5

Xing R, Liu G, Quan Q, Bhirde A, Zhang G, Jin A, Bryant LH, Zhang A, Liang A, Eden HS, Hou Y, Chen X
Functional MnO nanoclusters for efficient siRNA delivery.
Chem Commun (Camb), 2011 Nov 28;47(44):12152-4

Chen X
Protein and peptide probes for molecular imaging.
Amino Acids, 2011 Nov;41(5):1009-12

Lin X, Xie J, Chen X
Protein-based tumor molecular imaging probes.
Amino Acids, 2011 Nov;41(5):1013-36

Yan Y, Chen X
Peptide heterodimers for molecular imaging.
Amino Acids, 2011 Nov;41(5):1081-92

Cao Q, Liu S, Niu G, Chen K, Yan Y, Liu Z, Chen X
Phage display peptide probes for imaging early response to bevacizumab treatment.
Amino Acids, 2011 Nov;41(5):1103-12

Jiang HH, Kim TH, Lee S, Chen X, Youn YS, Lee KC
PEGylated TNF-related apoptosis-inducing ligand (TRAIL) for effective tumor combination therapy.
Biomaterials, 2011 Nov;32(33):8529-37

Chen X, Gambhir SS, Cheon J
Theranostic nanomedicine.
Acc Chem Res, 2011 Oct 18;44(10):841

Xie J, Liu G, Eden HS, Ai H, Chen X
Surface-engineered magnetic nanoparticle platforms for cancer imaging and therapy.
Acc Chem Res, 2011 Oct 18;44(10):883-92

Liu G, Xie J, Zhang F, Wang Z, Luo K, Zhu L, Quan Q, Niu G, Lee S, Ai H, Chen X
N-Alkyl-PEI-functionalized iron oxide nanoclusters for efficient siRNA delivery.
Small, 2011 Oct 4;7(19):2742-9

Quan Q, Xie J, Gao H, Yang M, Zhang F, Liu G, Lin X, Wang A, Eden HS, Lee S, Zhang G, Chen X
HSA coated iron oxide nanoparticles as drug delivery vehicles for cancer therapy.
Mol Pharm, 2011 Oct 3;8(5):1669-76

Gao H, Niu G, Yang M, Quan Q, Ma Y, Murage EN, Ahn JM, Kiesewetter DO, Chen X
PET of insulinoma using ¹8F-FBEM-EM3106B, a new GLP-1 analogue.
Mol Pharm, 2011 Oct 3;8(5):1775-82

Quan Q, Yang M, Gao H, Zhu L, Lin X, Guo N, Zhang G, Eden HS, Niu G, Chen X
Imaging tumor endothelial marker 8 using an 18F-labeled peptide.
Eur J Nucl Med Mol Imaging, 2011 Oct;38(10):1806-15

Lee S, Chen X
Selective imaging of mitochondrial surfaces with novel fluorescent probes.
Chembiochem, 2011 Sep 19;12(14):2120-1

Kim TH, Youn YS, Jiang HH, Lee S, Chen X, Lee KC
PEGylated TNF-related apoptosis-inducing ligand (TRAIL) analogues: pharmacokinetics and antitumor effects.
Bioconjug Chem, 2011 Aug 17;22(8):1631-7

Huang X, Lee S, Chen X
Design of "smart" probes for optical imaging of apoptosis.
Am J Nucl Med Mol Imaging, 2011 Aug 1;1(1):3-17

Wang F, Niu G, Chen X, Cao F
Molecular imaging of microRNAs.
Eur J Nucl Med Mol Imaging, 2011 Aug;38(8):1572-9

Zhang F, Niu G, Lu G, Chen X
Preclinical lymphatic imaging.
Mol Imaging Biol, 2011 Aug;13(4):599-612

Zhang F, Xie J, Liu G, He Y, Lu G, Chen X
In vivo MRI tracking of cell invasion and migration in a rat glioma model.
Mol Imaging Biol, 2011 Aug;13(4):695-701

Ananias HJ, Yu Z, Dierckx RA, van der Wiele C, Helfrich W, Wang F, Yan Y, Chen X, de Jong IJ, Elsinga PH
(99m)technetium-HYNIC(tricine/TPPTS)-Aca-bombesin(7-14) as a targeted imaging agent with microSPECT in a PC-3 prostate cancer xenograft model.
Mol Pharm, 2011 Aug 1;8(4):1165-73

Zhou Y, Kim YS, Yan X, Jacobson O, Chen X, Liu S
64Cu-labeled lissamine rhodamine B: a promising PET radiotracer targeting tumor mitochondria.
Mol Pharm, 2011 Aug 1;8(4):1198-208

Bhattacharjee AK, Lang L, Jacobson O, Shinkre B, Ma Y, Niu G, Trenkle WC, Jacobson KA, Chen X, Kiesewetter DO
Striatal adenosine A(2A) receptor-mediated positron emission tomographic imaging in 6-hydroxydopamine-lesioned rats using [(18)F]-MRS5425.
Nucl Med Biol, 2011 Aug;38(6):897-906

Niu G, Chen X
Size effect in molecular imaging of vascular endothelial growth factor.
Chem Biol, 2011 Jul 29;18(7):819-20

Zhang L, Li Y, Li DW, Jing C, Chen X, Lv M, Huang Q, Long YT, Willner I
Single gold nanoparticles as real-time optical probes for the detection of NADH-dependent intracellular metabolic enzymatic pathways.
Angew Chem Int Ed Engl, 2011 Jul 18;50(30):6789-92

Yan Y, Chen K, Yang M, Sun X, Liu S, Chen X
A new 18F-labeled BBN-RGD peptide heterodimer with a symmetric linker for prostate cancer imaging.
Amino Acids, 2011 Jul;41(2):439-47

Yang M, Gao H, Yan Y, Sun X, Chen K, Quan Q, Lang L, Kiesewetter D, Niu G, Chen X
PET imaging of early response to the tyrosine kinase inhibitor ZD4190.
Eur J Nucl Med Mol Imaging, 2011 Jul;38(7):1237-47

Mittra ES, Goris ML, Iagaru AH, Kardan A, Burton L, Berganos R, Chang E, Liu S, Shen B, Chin FT, Chen X, Gambhir SS
Pilot pharmacokinetic and dosimetric studies of (18)F-FPPRGD2: a PET radiopharmaceutical agent for imaging a(v)ß(3) integrin levels.
Radiology, 2011 Jul;260(1):182-91

Zhu L, Xie J, Swierczewska M, Zhang F, Lin X, Fang X, Niu G, Lee S, Chen X
Dual-functional, receptor-targeted fluorogenic probe for in vivo imaging of extracellular protease expressions.
Bioconjug Chem, 2011 Jun 15;22(6):1001-5

Karam JA, Huang S, Fan J, Stanfield J, Schultz RA, Pong RC, Sun X, Mason RP, Xie XJ, Niu G, Chen X, Frenkel EP, Sagalowsky AI, Hsieh JT
Upregulation of TRAG3 gene in urothelial carcinoma of the bladder.
Int J Cancer, 2011 Jun 15;128(12):2823-32

Swierczewska M, Lee S, Chen X
The design and application of fluorophore-gold nanoparticle activatable probes.
Phys Chem Chem Phys, 2011 Jun 7;13(21):9929-41

Lee SJ, Koo H, Lee DE, Min S, Lee S, Chen X, Choi Y, Leary JF, Park K, Jeong SY, Kwon IC, Kim K, Choi K
Tumor-homing photosensitizer-conjugated glycol chitosan nanoparticles for synchronous photodynamic imaging and therapy based on cellular on/off system.
Biomaterials, 2011 Jun;32(16):4021-9

Sun X, Niu G, Chan N, Shen B, Chen X
Tumor hypoxia imaging.
Mol Imaging Biol, 2011 Jun;13(3):399-410

Qin LX, Ma W, Li DW, Li Y, Chen X, Kraatz HB, James TD, Long YT
Coenzyme Q functionalized CdTe/ZnS quantum dots for reactive oxygen species (ROS) imaging.
Chemistry, 2011 May 2;17(19):5262-71

Lim SM, Kim TH, Jiang HH, Park CW, Lee S, Chen X, Lee KC
Improved biological half-life and anti-tumor activity of TNF-related apoptosis-inducing ligand (TRAIL) using PEG-exposed nanoparticles.
Biomaterials, 2011 May;32(13):3538-46

Xie J, Zhang F, Aronova M, Zhu L, Lin X, Quan Q, Liu G, Zhang G, Choi KY, Kim K, Sun X, Lee S, Sun S, Leapman R, Chen X
Manipulating the power of an additional phase: a flower-like Au-Fe3O4 optical nanosensor for imaging protease expressions in vivo.
ACS Nano, 2011 Apr 26;5(4):3043-51

Bhirde A, Guo N, Chen X
Targeted nanoprobes reveal early time point kinetics in vivo by time-resolved MRI.
Theranostics, 2011 Apr 26;1:274-6

Zhou Y, Kim YS, Shi J, Jacobson O, Chen X, Liu S
Evaluation of 64Cu-labeled acridinium cation: a PET radiotracer targeting tumor mitochondria.
Bioconjug Chem, 2011 Apr 20;22(4):700-8

Kim TH, Jiang HH, Lee S, Youn YS, Park CW, Byun Y, Chen X, Lee KC
Mono-PEGylated dimeric exendin-4 as high receptor binding and long-acting conjugates for type 2 anti-diabetes therapeutics.
Bioconjug Chem, 2011 Apr 20;22(4):625-32

Yang M, Gao H, Sun X, Yan Y, Quan Q, Zhang W, Mohamedali KA, Rosenblum MG, Niu G, Chen X
Multiplexed PET probes for imaging breast cancer early response to VEGF121/rGel treatment.
Mol Pharm, 2011 Apr 4;8(2):621-8

Liu Z, Shi J, Jia B, Yu Z, Liu Y, Zhao H, Li F, Tian J, Chen X, Liu S, Wang F
Two ?°Y-labeled multimeric RGD peptides RGD4 and 3PRGD2 for integrin targeted radionuclide therapy.
Mol Pharm, 2011 Apr 4;8(2):591-9

Jacobson O, Weiss ID, Niu G, Balboni G, Congiu C, Onnis V, Kiesewetter DO, Lattanzi R, Salvadori S, Chen X
Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain.
J Nucl Med, 2011 Apr;52(4):600-7

Liu G, Swierczewska M, Niu G, Zhang X, Chen X
Molecular imaging of cell-based cancer immunotherapy.
Mol Biosyst, 2011 Apr;7(4):993-1003

Zhu L, Wang H, Wang L, Wang Y, Jiang K, Li C, Ma Q, Gao S, Wang L, Li W, Cai M, Wang H, Niu G, Lee S, Yang W, Fang X, Chen X
High-affinity peptide against MT1-MMP for in vivo tumor imaging.
J Control Release, 2011 Mar 30;150(3):248-55

Jacobson O, Zhu L, Ma Y, Weiss ID, Sun X, Niu G, Kiesewetter DO, Chen X
Rapid and simple one-step F-18 labeling of peptides.
Bioconjug Chem, 2011 Mar 16;22(3):422-8

Gao J, Chen K, Miao Z, Ren G, Chen X, Gambhir SS, Cheng Z
Affibody-based nanoprobes for HER2-expressing cell and tumor imaging.
Biomaterials, 2011 Mar;32(8):2141-8

Patel S, Bhirde AA, Rusling JF, Chen X, Gutkind JS, Patel V
Nano Delivers Big: Designing Molecular Missiles for Cancer Therapeutics.
Pharmaceutics, 2011 Mar;3(1):34-52

Liu Z, Wang F, Chen X
Integrin targeted delivery of radiotherapeutics.
Theranostics, 2011 Mar 1;1:201-10

Kim TH, Jiang HH, Park CW, Youn YS, Lee S, Chen X, Lee KC
PEGylated TNF-related apoptosis-inducing ligand (TRAIL)-loaded sustained release PLGA microspheres for enhanced stability and antitumor activity.
J Control Release, 2011 Feb 28;150(1):63-9

Chen K, Chen X
Integrin targeted delivery of chemotherapeutics.
Theranostics, 2011 Feb 17;1:189-200

Lee S, Choi KY, Chung H, Ryu JH, Lee A, Koo H, Youn IC, Park JH, Kim IS, Kim SY, Chen X, Jeong SY, Kwon IC, Kim K, Choi K
Real time, high resolution video imaging of apoptosis in single cells with a polymeric nanoprobe.
Bioconjug Chem, 2011 Feb 16;22(2):125-31

Ye Y, Zhu L, Ma Y, Niu G, Chen X
Synthesis and evaluation of new iRGD peptide analogs for tumor optical imaging.
Bioorg Med Chem Lett, 2011 Feb 15;21(4):1146-50

Lin X, Xie J, Zhu L, Lee S, Niu G, Ma Y, Kim K, Chen X
Hybrid ferritin nanoparticles as activatable probes for tumor imaging.
Angew Chem Int Ed Engl, 2011 Feb 11;50(7):1569-72

Lin X, Xie J, Niu G, Zhang F, Gao H, Yang M, Quan Q, Aronova MA, Zhang G, Lee S, Leapman R, Chen X
Chimeric ferritin nanocages for multiple function loading and multimodal imaging.
Nano Lett, 2011 Feb 9;11(2):814-9

Gu D, Ma Y, Niu G, Yan Y, Lang L, Aisa HA, Gao H, Kiesewetter DO, Chen X
LC/MS evaluation of metabolism and membrane transport of bombesin peptides.
Amino Acids, 2011 Feb;40(2):669-75

Kiesewetter DO, Jacobson O, Lang L, Chen X
Automated radiochemical synthesis of [18F]FBEM: a thiol reactive synthon for radiofluorination of peptides and proteins.
Appl Radiat Isot, 2011 Feb;69(2):410-4

Michalski MH, Chen X
Molecular imaging in cancer treatment.
Eur J Nucl Med Mol Imaging, 2011 Feb;38(2):358-77

Swierczewska M, Lee S, Chen X
Inorganic nanoparticles for multimodal molecular imaging.
Mol Imaging, 2011 Feb;10(1):3-16

Bu L, Li R, Jin Z, Wen X, Liu S, Yang B, Shen B, Chen X
Evaluation of (99)? (m)TcN-MPO as a new myocardial perfusion imaging agent in normal dogs and in an acute myocardial infarction canine model: comparison with (99)? (m)Tc-sestamibi.
Mol Imaging Biol, 2011 Feb;13(1):121-7

Wang J, Xie J, Zhou X, Cheng Z, Gu N, Teng G, Hu Q, Zhu F, Chang S, Zhang F, Lu G, Chen X
Ferritin enhances SPIO tracking of C6 rat glioma cells by MRI.
Mol Imaging Biol, 2011 Feb;13(1):87-93

Liu Z, Jia B, Zhao H, Chen X, Wang F
Specific targeting of human integrin a(v)ß (3) with (111)In-labeled Abegrin™ in nude mouse models.
Mol Imaging Biol, 2011 Feb;13(1):112-20

Chen K, Chen X
Positron emission tomography imaging of cancer biology: current status and future prospects.
Semin Oncol, 2011 Feb;38(1):70-86

Kim TH, Jiang HH, Youn YS, Park CW, Tak KK, Lee S, Kim H, Jon S, Chen X, Lee KC
Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity.
Int J Pharm, 2011 Jan 17;403(1-2):285-91

Chen X
Integrin Targeted Imaging and Therapy.
Theranostics, 2011 Jan 12;2011(1):28-29

Chen XS
Introducing Theranostics Journal - From the Editor-in-Chief.
Theranostics, 2011 Jan 8;1:1-2

Liu G, Wang Z, Lu J, Xia C, Gao F, Gong Q, Song B, Zhao X, Shuai X, Chen X, Ai H, Gu Z
Low molecular weight alkyl-polycation wrapped magnetite nanoparticle clusters as MRI probes for stem cell labeling and in vivo imaging.
Biomaterials, 2011 Jan;32(2):528-37

Sun X, Yan Y, Liu S, Cao Q, Yang M, Neamati N, Shen B, Niu G, Chen X
18F-FPPRGD2 and 18F-FDG PET of response to Abraxane therapy.
J Nucl Med, 2011 Jan;52(1):140-6

Bhirde A, Xie J, Swierczewska M, Chen X
Nanoparticles for cell labeling.
Nanoscale, 2011 Jan;3(1):142-53

Lang L, Li W, Jia HM, Fang DC, Zhang S, Sun X, Zhu L, Ma Y, Shen B, Kiesewetter DO, Niu G, Chen X
New Methods for Labeling RGD Peptides with Bromine-76.
Theranostics, 2011;1:341-53

Zhang F, Zhu L, Liu G, Hida N, Lu G, Eden HS, Niu G, Chen X
Multimodality imaging of tumor response to doxil.
Theranostics, 2011;1:302-9

Bhirde AA, Liu G, Jin A, Iglesias-Bartolome R, Sousa AA, Leapman RD, Gutkind JS, Lee S, Chen X
Combining portable Raman probes with nanotubes for theranostic applications.
Theranostics, 2011;1:310-21

Ye Y, Chen X
Integrin targeting for tumor optical imaging.
Theranostics, 2011;1:102-26

Jacobson O, Weiss ID, Szajek LP, Niu G, Ma Y, Kiesewetter DO, Farber JM, Chen X
PET imaging of CXCR4 using copper-64 labeled peptide antagonist.
Theranostics, 2011;1:251-62

Niu G, Chen X
Why integrin as a primary target for imaging and therapy.
Theranostics, 2011;1:30-47

Yang M, Gao H, Zhou Y, Ma Y, Quan Q, Lang L, Chen K, Niu G, Yan Y, Chen X
F-Labeled GRPR Agonists and Antagonists: A Comparative Study in Prostate Cancer Imaging.
Theranostics, 2011;1:220-9

Zhu L, Xie J, Swierczewska M, Zhang F, Quan Q, Ma Y, Fang X, Kim K, Lee S, Chen X
Real-time video imaging of protease expression in vivo.
Theranostics, 2011;1:18-27

2010

Huang J, Bu L, Xie J, Chen K, Cheng Z, Li X, Chen X
Effects of nanoparticle size on cellular uptake and liver MRI with polyvinylpyrrolidone-coated iron oxide nanoparticles.
ACS Nano, 2010 Dec 28;4(12):7151-60

Liu G, Swierczewska M, Lee S, Chen X
FUNCTIONAL NANOPARTICLES FOR MOLECULAR IMAGING GUIDED GENE DELIVERY.
Nano Today, 2010 Dec 1;5(6):524-539

Jang ES, Won JH, Kim YW, Chen X, Choy JH
Soft-solution route to various ZnO nanoplate arrays.
CrystEngComm, 2010 Nov;12(11):3467-3470

Ma Z, Ma Y, Sun X, Ye Y, Shen B, Chen X, Ito Y
Purification of optical imaging ligand-Cybesin by high-speed counter-current chromatography.
J Chromatogr B Analyt Technol Biomed Life Sci, 2010 Nov 1;878(29):3039-43

Niu G, Chen X
Apoptosis imaging: beyond annexin V.
J Nucl Med, 2010 Nov;51(11):1659-62

Jacobson O, Weiss ID, Kiesewetter DO, Farber JM, Chen X
PET of tumor CXCR4 expression with 4-18F-T140.
J Nucl Med, 2010 Nov;51(11):1796-804

Wang K, Wang K, Shen B, Huang T, Sun X, Li W, Jin G, Li L, Bu L, Li R, Wang D, Chen X
MR reporter gene imaging of endostatin expression and therapy.
Mol Imaging Biol, 2010 Oct;12(5):520-9

Liu S, Liu Z, Chen K, Yan Y, Watzlowik P, Wester HJ, Chin FT, Chen X
18F-labeled galacto and PEGylated RGD dimers for PET imaging of avß3 integrin expression.
Mol Imaging Biol, 2010 Oct;12(5):530-8

Ming X, Alam MR, Fisher M, Yan Y, Chen X, Juliano RL
Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor.
Nucleic Acids Res, 2010 Oct;38(19):6567-76

Huang J, Xie J, Chen K, Bu L, Lee S, Cheng Z, Li X, Chen X
HSA coated MnO nanoparticles with prominent MRI contrast for tumor imaging.
Chem Commun (Camb), 2010 Sep 28;46(36):6684-6

Xie J, Lee S, Chen X
Nanoparticle-based theranostic agents.
Adv Drug Deliv Rev, 2010 Aug 30;62(11):1064-79

Sun X, Niu G, Yan Y, Yang M, Chen K, Ma Y, Chan N, Shen B, Chen X
Phage display-derived peptides for osteosarcoma imaging.
Clin Cancer Res, 2010 Aug 15;16(16):4268-77

Niu G, Chen X
Vascular endothelial growth factor as an anti-angiogenic target for cancer therapy.
Curr Drug Targets, 2010 Aug;11(8):1000-17

Beer AJ, Chen X
Imaging of angiogenesis: from morphology to molecules and from bench to bedside.
Eur J Nucl Med Mol Imaging, 2010 Aug;37 Suppl 1:S1-3

Haubner R, Beer AJ, Wang H, Chen X
Positron emission tomography tracers for imaging angiogenesis.
Eur J Nucl Med Mol Imaging, 2010 Aug;37 Suppl 1:S86-103

Liu Z, Liu Y, Jia B, Zhao H, Jin X, Li F, Chen X, Wang F
Epidermal growth factor receptor-targeted radioimmunotherapy of human head and neck cancer xenografts using 90Y-labeled fully human antibody panitumumab.
Mol Cancer Ther, 2010 Aug;9(8):2297-308

Ma Y, Kiesewetter DO, Lang L, Gu D, Chen X
Applications of LC-MS in PET radioligand development and metabolic elucidation.
Curr Drug Metab, 2010 Jul;11(6):483-93

de la Zerda A, Liu Z, Bodapati S, Teed R, Vaithilingam S, Khuri-Yakub BT, Chen X, Dai H, Gambhir SS
Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice.
Nano Lett, 2010 Jun 9;10(6):2168-72

Liu J, Wang Y, Qu X, Li X, Ma X, Han R, Hu Z, Chen X, Sun D, Zhang R, Chen D, Chen D, Chen X, Liang J, Cao F, Tian J
In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models.
Opt Express, 2010 Jun 7;18(12):13102-13

Chae SY, Kim TH, Park K, Jin CH, Son S, Lee S, Youn YS, Kim K, Jo DG, Kwon IC, Chen X, Lee KC
Improved antitumor activity and tumor targeting of NH(2)-terminal-specific PEGylated tumor necrosis factor-related apoptosis-inducing ligand.
Mol Cancer Ther, 2010 Jun;9(6):1719-29

Lee S, Xie J, Chen X
Peptides and peptide hormones for molecular imaging and disease diagnosis.
Chem Rev, 2010 May 12;110(5):3087-111

Zhao R, Deng J, Liang X, Zeng J, Chen X, Wang J
Treatment of cystic craniopharyngioma with phosphorus-32 intracavitary irradiation.
Childs Nerv Syst, 2010 May;26(5):669-74

Anderson CJ, Bulte JW, Chen K, Chen X, Khaw BA, Shokeen M, Wooley KL, VanBrocklin HF
Design of targeted cardiovascular molecular imaging probes.
J Nucl Med, 2010 May 1;51 Suppl 1:3S-17S

Gao J, Chen K, Xie R, Xie J, Yan Y, Cheng Z, Peng X, Chen X
In vivo tumor-targeted fluorescence imaging using near-infrared non-cadmium quantum dots.
Bioconjug Chem, 2010 Apr 21;21(4):604-9

Xie J, Chen K, Huang J, Lee S, Wang J, Gao J, Li X, Chen X
PET/NIRF/MRI triple functional iron oxide nanoparticles.
Biomaterials, 2010 Apr;31(11):3016-22

Niu G, Sun X, Cao Q, Courter D, Koong A, Le QT, Gambhir SS, Chen X
Cetuximab-based immunotherapy and radioimmunotherapy of head and neck squamous cell carcinoma.
Clin Cancer Res, 2010 Apr 1;16(7):2095-105

Sun A, Hou L, Prugpichailers T, Dunkel J, Kalani MA, Chen X, Kalani MY, Tse V
Firefly luciferase-based dynamic bioluminescence imaging: a noninvasive technique to assess tumor angiogenesis.
Neurosurgery, 2010 Apr;66(4):751-7; discussion 757

Alam MR, Ming X, Dixit V, Fisher M, Chen X, Juliano RL
The biological effect of an antisense oligonucleotide depends on its route of endocytosis and trafficking.
Oligonucleotides, 2010 Apr;20(2):103-9

Lee S, Xie J, Chen X
Peptide-based probes for targeted molecular imaging.
Biochemistry, 2010 Feb 23;49(7):1364-76

Liu Z, Liu S, Niu G, Wang F, Liu S, Chen X
Optical imaging of integrin alphavbeta3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers.
Mol Imaging, 2010 Feb;9(1):21-9

Xie J, Wang J, Niu G, Huang J, Chen K, Li X, Chen X
Human serum albumin coated iron oxide nanoparticles for efficient cell labeling.
Chem Commun (Camb), 2010 Jan 21;46(3):433-5

Gao S, Chen X, Yi Q, Wang G, Pan G, Lin A, Peng G
A strategy for the proliferation of Ulva prolifera, main causative species of green tides, with formation of sporangia by fragmentation.
PLoS One, 2010 Jan 5;5(1):e8571

Chen XS
The medicinal chemistry of targeted tumor imaging (II).
Curr Top Med Chem, 2010;10(12):1145-6

Chen XS
The medicinal chemistry of targeted tumor imaging (I).
Curr Top Med Chem, 2010;10(11):1046-7

Jacobson O, Chen X
PET designated flouride-18 production and chemistry.
Curr Top Med Chem, 2010;10(11):1048-59

Lee S, Xie J, Chen X
Activatable molecular probes for cancer imaging.
Curr Top Med Chem, 2010;10(11):1135-44

Gao J, Chen X, Cheng Z
Near-infrared quantum dots as optical probes for tumor imaging.
Curr Top Med Chem, 2010;10(12):1147-57

Chen K, Chen X
Design and development of molecular imaging probes.
Curr Top Med Chem, 2010;10(12):1227-36

Gao J, Chen K, Xie R, Xie J, Lee S, Cheng Z, Peng X, Chen X
Ultrasmall near-infrared non-cadmium quantum dots for in vivo tumor imaging.
Small, 2010 Jan;6(2):256-61

2009

Wang K, Wang K, Li W, Huang T, Li R, Wang D, Shen B, Chen X
Characterizing breast cancer xenograft epidermal growth factor receptor expression by using near-infrared optical imaging.
Acta Radiol, 2009 Dec;50(10):1095-103

Chen K, Xie J, Xu H, Behera D, Michalski MH, Biswal S, Wang A, Chen X
Triblock copolymer coated iron oxide nanoparticle conjugate for tumor integrin targeting.
Biomaterials, 2009 Dec;30(36):6912-9

Lee S, Ryu JH, Park K, Lee A, Lee SY, Youn IC, Ahn CH, Yoon SM, Myung SJ, Moon DH, Chen X, Choi K, Kwon IC, Kim K
Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo.
Nano Lett, 2009 Dec;9(12):4412-6

Chen X, Ji M, Fisher DR, Wai CM
Ionizable Calixarene-Crown Ethers with High Selectivity for Radium over Light Alkaline Earth Metal Ions.
Inorg Chem, 2009 Nov 15;38(23):5449-5452

Li ZB, Chen K, Wu Z, Wang H, Niu G, Chen X
64Cu-labeled PEGylated polyethylenimine for cell trafficking and tumor imaging.
Mol Imaging Biol, 2009 Nov-Dec;11(6):415-23

Ren C, Yan Z, Wei D, Gao X, Chen X, Zhao H
Limb remote ischemic postconditioning protects against focal ischemia in rats.
Brain Res, 2009 Sep 8;1288:88-94

Niu G, Li Z, Cao Q, Chen X
Monitoring therapeutic response of human ovarian cancer to 17-DMAG by noninvasive PET imaging with (64)Cu-DOTA-trastuzumab.
Eur J Nucl Med Mol Imaging, 2009 Sep;36(9):1510-9

Liu Z, Niu G, Wang F, Chen X
(68)Ga-labeled NOTA-RGD-BBN peptide for dual integrin and GRPR-targeted tumor imaging.
Eur J Nucl Med Mol Imaging, 2009 Sep;36(9):1483-94

Liu Z, Liu S, Wang F, Liu S, Chen X
Noninvasive imaging of tumor integrin expression using (18)F-labeled RGD dimer peptide with PEG (4) linkers.
Eur J Nucl Med Mol Imaging, 2009 Aug;36(8):1296-307

Wang H, Chen X
Applications for site-directed molecular imaging agents coupled with drug delivery potential.
Expert Opin Drug Deliv, 2009 Jul;6(7):745-68

Niu G, Li Z, Xie J, Le QT, Chen X
PET of EGFR antibody distribution in head and neck squamous cell carcinoma models.
J Nucl Med, 2009 Jul;50(7):1116-23

Liu Z, Li ZB, Cao Q, Liu S, Wang F, Chen X
Small-animal PET of tumors with (64)Cu-labeled RGD-bombesin heterodimer.
J Nucl Med, 2009 Jul;50(7):1168-77

Wang H, Cao F, De A, Cao Y, Contag C, Gambhir SS, Wu JC, Chen X
Trafficking mesenchymal stem cell engraftment and differentiation in tumor-bearing mice by bioluminescence imaging.
Stem Cells, 2009 Jul;27(7):1548-58

Liu Z, Niu G, Shi J, Liu S, Wang F, Liu S, Chen X
(68)Ga-labeled cyclic RGD dimers with Gly3 and PEG4 linkers: promising agents for tumor integrin alphavbeta3 PET imaging.
Eur J Nucl Med Mol Imaging, 2009 Jun;36(6):947-57

Liu Z, Yan Y, Liu S, Wang F, Chen X
(18)F, (64)Cu, and (68)Ga labeled RGD-bombesin heterodimeric peptides for PET imaging of breast cancer.
Bioconjug Chem, 2009 May 20;20(5):1016-25

Niu G, Chen X
From protein-protein interaction to therapy response: molecular imaging of heat shock proteins.
Eur J Radiol, 2009 May;70(2):294-304

Shi J, Kim YS, Zhai S, Liu Z, Chen X, Liu S
Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers.
Bioconjug Chem, 2009 Apr;20(4):750-9

Cao F, Li Z, Lee A, Liu Z, Chen K, Wang H, Cai W, Chen X, Wu JC
Noninvasive de novo imaging of human embryonic stem cell-derived teratoma formation.
Cancer Res, 2009 Apr 1;69(7):2709-13

Xie J, Chen K, Chen X
Production, Modification and Bio-Applications of Magnetic Nanoparticles Gestated by Magnetotactic Bacteria.
Nano Res, 2009 Apr;2(4):261-278

Lee S, Chen X
Dual-modality probes for in vivo molecular imaging.
Mol Imaging, 2009 Mar-Apr;8(2):87-100

Chen K, Xie J, Chen X
RGD-human serum albumin conjugates as efficient tumor targeting probes.
Mol Imaging, 2009 Mar-Apr;8(2):65-73

Niu G, Chen X
Noninvasive visualization of microRNA by bioluminescence imaging.
Mol Imaging Biol, 2009 Mar-Apr;11(2):61-3

Tobinick EL, Chen K, Chen X
Rapid intracerebroventricular delivery of Cu-DOTA-etanercept after peripheral administration demonstrated by PET imaging.
BMC Res Notes, 2009 Feb 27;2:28

Liu Z, Yan Y, Chin FT, Wang F, Chen X
Dual integrin and gastrin-releasing peptide receptor targeted tumor imaging using 18F-labeled PEGylated RGD-bombesin heterodimer 18F-FB-PEG3-Glu-RGD-BBN.
J Med Chem, 2009 Jan 22;52(2):425-32

Liu Z, Fan AC, Rakhra K, Sherlock S, Goodwin A, Chen X, Yang Q, Felsher DW, Dai H
Supramolecular stacking of doxorubicin on carbon nanotubes for in vivo cancer therapy.
Angew Chem Int Ed Engl, 2009;48(41):7668-72

Li ZB, Chen X
MicroPET, MicroSPECT, and NIR fluorescence imaging of biomolecules in vivo.
Methods Mol Biol, 2009;544:461-81

Chen K, Cai W, Li ZB, Wang H, Chen X
Quantitative PET imaging of VEGF receptor expression.
Mol Imaging Biol, 2009 Jan-Feb;11(1):15-22

Wang H, Chen K, Niu G, Chen X
Site-specifically biotinylated VEGF(121) for near-infrared fluorescence imaging of tumor angiogenesis.
Mol Pharm, 2009 Jan-Feb;6(1):285-94

Wang L, Shi J, Kim YS, Zhai S, Jia B, Zhao H, Liu Z, Wang F, Chen X, Liu S
Improving tumor-targeting capability and pharmacokinetics of (99m)Tc-labeled cyclic RGD dimers with PEG(4) linkers.
Mol Pharm, 2009 Jan-Feb;6(1):231-45

Niu G, Chen X
PET Imaging of Angiogenesis.
PET Clin, 2009 Jan 1;4(1):17-38

Schipper ML, Iyer G, Koh AL, Cheng Z, Ebenstein Y, Aharoni A, Keren S, Bentolila LA, Li J, Rao J, Chen X, Banin U, Wu AM, Sinclair R, Weiss S, Gambhir SS
Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice.
Small, 2009 Jan;5(1):126-34

Cai W, Guzman R, Hsu AR, Wang H, Chen K, Sun G, Gera A, Choi R, Bliss T, He L, Li ZB, Maag AL, Hori N, Zhao H, Moseley M, Steinberg GK, Chen X
Positron emission tomography imaging of poststroke angiogenesis.
Stroke, 2009 Jan;40(1):270-7

2008

Shi J, Wang L, Kim YS, Zhai S, Liu Z, Chen X, Liu S
Improving tumor uptake and excretion kinetics of 99mTc-labeled cyclic arginine-glycine-aspartic (RGD) dimers with triglycine linkers.
J Med Chem, 2008 Dec 25;51(24):7980-90

Xie R, Chen K, Chen X, Peng X
InAs/InP/ZnSe Core/Shell/Shell Quantum Dots as Near-Infrared Emitters: Bright, Narrow-Band, Non-Cadmium Containing, and Biocompatible.
Nano Res, 2008 Dec 14;1(6):457-464

Chen K, Li ZB, Wang H, Cai W, Chen X
Dual-modality optical and positron emission tomography imaging of vascular endothelial growth factor receptor on tumor vasculature using quantum dots.
Eur J Nucl Med Mol Imaging, 2008 Dec;35(12):2235-44

Veeravagu A, Liu Z, Niu G, Chen K, Jia B, Cai W, Jin C, Hsu AR, Connolly AJ, Tse V, Wang F, Chen X
Integrin alphavbeta3-targeted radioimmunotherapy of glioblastoma multiforme.
Clin Cancer Res, 2008 Nov 15;14(22):7330-9

Veeravagu A, Hou LC, Hsu AR, Cai W, Greve JM, Chen X, Tse V
The temporal correlation of dynamic contrast-enhanced magnetic resonance imaging with tumor angiogenesis in a murine glioblastoma model.
Neurol Res, 2008 Nov;30(9):952-9

Yang CT, Kim YS, Wang J, Wang L, Shi J, Li ZB, Chen X, Fan M, Li JJ, Liu S
64Cu-labeled 2-(diphenylphosphoryl)ethyldiphenylphosphonium cations as highly selective tumor imaging agents: effects of linkers and chelates on radiotracer biodistribution characteristics.
Bioconjug Chem, 2008 Oct;19(10):2008-22

Cao Q, Cai W, Niu G, He L, Chen X
Multimodality imaging of IL-18--binding protein-Fc therapy of experimental lung metastasis.
Clin Cancer Res, 2008 Oct 1;14(19):6137-45

Wang H, Chen X
Imaging mesenchymal stem cell migration and the implications for stem cell-based cancer therapies.
Future Oncol, 2008 Oct;4(5):623-8

Huang M, Chan DA, Jia F, Xie X, Li Z, Hoyt G, Robbins RC, Chen X, Giaccia AJ, Wu JC
Short hairpin RNA interference therapy for ischemic heart disease.
Circulation, 2008 Sep 30;118(14 Suppl):S226-33

De la Zerda A, Zavaleta C, Keren S, Vaithilingam S, Bodapati S, Liu Z, Levi J, Smith BR, Ma TJ, Oralkan O, Cheng Z, Chen X, Dai H, Khuri-Yakub BT, Gambhir SS
Carbon nanotubes as photoacoustic molecular imaging agents in living mice.
Nat Nanotechnol, 2008 Sep;3(9):557-62

Liu Z, Chen K, Davis C, Sherlock S, Cao Q, Chen X, Dai H
Drug delivery with carbon nanotubes for in vivo cancer treatment.
Cancer Res, 2008 Aug 15;68(16):6652-60

Li ZB, Niu G, Wang H, He L, Yang L, Ploug M, Chen X
Imaging of urokinase-type plasminogen activator receptor expression using a 64Cu-labeled linear peptide antagonist by microPET.
Clin Cancer Res, 2008 Aug 1;14(15):4758-66

Cao Q, Li ZB, Chen K, Wu Z, He L, Neamati N, Chen X
Evaluation of biodistribution and anti-tumor effect of a dimeric RGD peptide-paclitaxel conjugate in mice with breast cancer.
Eur J Nucl Med Mol Imaging, 2008 Aug;35(8):1489-98

Lee HY, Li Z, Chen K, Hsu AR, Xu C, Xie J, Sun S, Chen X
PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles.
J Nucl Med, 2008 Aug;49(8):1371-9

Xie J, Chen K, Lee HY, Xu C, Hsu AR, Peng S, Chen X, Sun S
Ultrasmall c(RGDyK)-coated Fe3O4 nanoparticles and their specific targeting to integrin alpha(v)beta3-rich tumor cells.
J Am Chem Soc, 2008 Jun 18;130(24):7542-3

Shi J, Jia B, Liu Z, Yang Z, Yu Z, Chen K, Chen X, Liu S, Wang F
99mTc-labeled bombesin(7-14)NH2 with favorable properties for SPECT imaging of colon cancer.
Bioconjug Chem, 2008 Jun;19(6):1170-8

Li ZB, Chen K, Chen X
(68)Ga-labeled multimeric RGD peptides for microPET imaging of integrin alpha(v)beta (3) expression.
Eur J Nucl Med Mol Imaging, 2008 Jun;35(6):1100-8

Cai W, Chen X
Multimodality molecular imaging of tumor angiogenesis.
J Nucl Med, 2008 Jun;49 Suppl 2:113S-28S

Kim YS, Yang CT, Wang J, Wang L, Li ZB, Chen X, Liu S
Effects of targeting moiety, linker, bifunctional chelator, and molecular charge on biological properties of 64Cu-labeled triphenylphosphonium cations.
J Med Chem, 2008 May 22;51(10):2971-84

Wang H, Chen K, Cai W, Li Z, He L, Kashefi A, Chen X
Integrin-targeted imaging and therapy with RGD4C-TNF fusion protein.
Mol Cancer Ther, 2008 May;7(5):1044-53

Alam MR, Dixit V, Kang H, Li ZB, Chen X, Trejo J, Fisher M, Juliano RL
Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis.
Nucleic Acids Res, 2008 May;36(8):2764-76

Rodriguez-Porcel M, Cai W, Gheysens O, Willmann JK, Chen K, Wang H, Chen IY, He L, Wu JC, Li ZB, Mohamedali KA, Kim S, Rosenblum MG, Chen X, Gambhir SS
Imaging of VEGF receptor in a rat myocardial infarction model using PET.
J Nucl Med, 2008 Apr;49(4):667-73

Hsu AR, Chen X
Advances in anatomic, functional, and molecular imaging of angiogenesis.
J Nucl Med, 2008 Apr;49(4):511-4

Lee HY, Lee SH, Xu C, Xie J, Lee JH, Wu B, Koh AL, Wang X, Sinclair R, Wang SX, Nishimura DG, Biswal S, Sun S, Cho SH, Chen X
Synthesis and characterization of PVP-coated large core iron oxide nanoparticles as an MRI contrast agent.
Nanotechnology, 2008 Apr;19(16):165101

Ryu EK, Wu Z, Chen K, Lazarus LH, Marczak ED, Sasaki Y, Ambo A, Salvadori S, Ren C, Zhao H, Balboni G, Chen X
Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging.
J Med Chem, 2008 Mar 27;51(6):1817-23

Li ZB, Wu Z, Chen K, Ryu EK, Chen X
18F-labeled BBN-RGD heterodimer for prostate cancer imaging.
J Nucl Med, 2008 Mar;49(3):453-61

Chin FT, Namavari M, Levi J, Subbarayan M, Ray P, Chen X, Gambhir SS
Semiautomated radiosynthesis and biological evaluation of [18F]FEAU: a novel PET imaging agent for HSV1-tk/sr39tk reporter gene expression.
Mol Imaging Biol, 2008 Mar-Apr;10(2):82-91

Niu G, Cai W, Chen K, Chen X
Non-invasive PET imaging of EGFR degradation induced by a heat shock protein 90 inhibitor.
Mol Imaging Biol, 2008 Mar-Apr;10(2):99-106

Li ZB, Wu Z, Cao Q, Dick DW, Tseng JR, Gambhir SS, Chen X
The synthesis of 18F-FDS and its potential application in molecular imaging.
Mol Imaging Biol, 2008 Mar-Apr;10(2):92-8

Willmann JK, Chen K, Wang H, Paulmurugan R, Rollins M, Cai W, Wang DS, Chen IY, Gheysens O, Rodriguez-Porcel M, Chen X, Gambhir SS
Monitoring of the biological response to murine hindlimb ischemia with 64Cu-labeled vascular endothelial growth factor-121 positron emission tomography.
Circulation, 2008 Feb 19;117(7):915-22

Liu Z, Davis C, Cai W, He L, Chen X, Dai H
Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy.
Proc Natl Acad Sci U S A, 2008 Feb 5;105(5):1410-5

Willmann JK, Paulmurugan R, Chen K, Gheysens O, Rodriguez-Porcel M, Lutz AM, Chen IY, Chen X, Gambhir SS
US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice.
Radiology, 2008 Feb;246(2):508-18

Cai W, Niu G, Chen X
Imaging of integrins as biomarkers for tumor angiogenesis.
Curr Pharm Des, 2008;14(28):2943-73

Liu Z, Wang F, Chen X
Integrin alpha(v)beta(3)-Targeted Cancer Therapy.
Drug Dev Res, 2008;69(6):329-339

Niu G, Chen X
Has molecular and cellular imaging enhanced drug discovery and drug development?
Drugs R D, 2008;9(6):351-68

Cai W, Niu G, Chen X
Multimodality imaging of the HER-kinase axis in cancer.
Eur J Nucl Med Mol Imaging, 2008 Jan;35(1):186-208

Wang H, Chen X
Site-specifically modified fusion proteins for molecular imaging.
Front Biosci, 2008 Jan 1;13:1716-32

Kashefi A, Zhao H, Chen X
Molecular imaging as the main part of our decision-making and treatment strategies in stroke.
Front Biosci, 2008 Jan 1;13:1535-56

Niu G, Cai W, Chen X
Molecular imaging of human epidermal growth factor receptor 2 (HER-2) expression.
Front Biosci, 2008 Jan 1;13:790-805

Ryu EK, Chen X
Development of Alzheimer's disease imaging agents for clinical studies.
Front Biosci, 2008 Jan 1;13:777-89

Cai W, Gambhir SS, Chen X
Chapter 7. Molecular imaging of tumor vasculature.
Methods Enzymol, 2008;445:141-76

Cai W, Chen X
Preparation of peptide-conjugated quantum dots for tumor vasculature-targeted imaging.
Nat Protoc, 2008;3(1):89-96

Ren C, Gao X, Niu G, Yan Z, Chen X, Zhao H
Delayed postconditioning protects against focal ischemic brain injury in rats.
PLoS One, 2008;3(12):e3851

2007

Wang H, Cai W, Chen K, Li ZB, Kashefi A, He L, Chen X
A new PET tracer specific for vascular endothelial growth factor receptor 2.
Eur J Nucl Med Mol Imaging, 2007 Dec;34(12):2001-10

Cai W, Ebrahimnejad A, Chen K, Cao Q, Li ZB, Tice DA, Chen X
Quantitative radioimmunoPET imaging of EphA2 in tumor-bearing mice.
Eur J Nucl Med Mol Imaging, 2007 Dec;34(12):2024-36

Li ZB, Wu Z, Chen K, Chin FT, Chen X
Click chemistry for (18)F-labeling of RGD peptides and microPET imaging of tumor integrin alphavbeta3 expression.
Bioconjug Chem, 2007 Nov-Dec;18(6):1987-94

Cao Q, Cai W, Li ZB, Chen K, He L, Li HC, Hui M, Chen X
PET imaging of acute and chronic inflammation in living mice.
Eur J Nucl Med Mol Imaging, 2007 Nov;34(11):1832-42

Wu Z, Li ZB, Cai W, He L, Chin FT, Li F, Chen X
18F-labeled mini-PEG spacered RGD dimer (18F-FPRGD2): synthesis and microPET imaging of alphavbeta3 integrin expression.
Eur J Nucl Med Mol Imaging, 2007 Nov;34(11):1823-31

Cai W, Chen K, Li ZB, Gambhir SS, Chen X
Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature.
J Nucl Med, 2007 Nov;48(11):1862-70

Cai W, Chen X
Nanoplatforms for targeted molecular imaging in living subjects.
Small, 2007 Nov;3(11):1840-54

Wang J, Yang CT, Kim YS, Sreerama SG, Cao Q, Li ZB, He Z, Chen X, Liu S
64Cu-Labeled triphenylphosphonium and triphenylarsonium cations as highly tumor-selective imaging agents.
J Med Chem, 2007 Oct 18;50(21):5057-69

Iagaru A, Chen X, Gambhir SS
Molecular imaging can accelerate anti-angiogenic drug development and testing.
Nat Clin Pract Oncol, 2007 Oct;4(10):556-7

Wu Z, Li ZB, Chen K, Cai W, He L, Chin FT, Li F, Chen X
microPET of tumor integrin alphavbeta3 expression using 18F-labeled PEGylated tetrameric RGD peptide (18F-FPRGD4).
J Nucl Med, 2007 Sep;48(9):1536-44

Schipper ML, Cheng Z, Lee SW, Bentolila LA, Iyer G, Rao J, Chen X, Wu AM, Weiss S, Gambhir SS
microPET-based biodistribution of quantum dots in living mice.
J Nucl Med, 2007 Sep;48(9):1511-8

Li ZB, Cai W, Chen X
Semiconductor quantum dots for in vivo imaging.
J Nanosci Nanotechnol, 2007 Aug;7(8):2567-81

Li ZB, Cai W, Cao Q, Chen K, Wu Z, He L, Chen X
(64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression.
J Nucl Med, 2007 Jul;48(7):1162-71

Cai W, Chen K, He L, Cao Q, Koong A, Chen X
Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody.
Eur J Nucl Med Mol Imaging, 2007 Jun;34(6):850-8

Cheng Z, Zhang L, Graves E, Xiong Z, Dandekar M, Chen X, Gambhir SS
Small-animal PET of melanocortin 1 receptor expression using a 18F-labeled alpha-melanocyte-stimulating hormone analog.
J Nucl Med, 2007 Jun;48(6):987-94

Cai W, Hsu AR, Li ZB, Chen X
Are quantum dots ready for in vivo imaging in human subjects?
Nanoscale Res Lett, 2007 Jun;2(6):265-281

Hsu AR, Veeravagu A, Cai W, Hou LC, Tse V, Chen X
Integrin alpha v beta 3 antagonists for anti-angiogenic cancer treatment.
Recent Pat Anticancer Drug Discov, 2007 Jun;2(2):143-58

Cheng Z, Xiong Z, Subbarayan M, Chen X, Gambhir SS
64Cu-labeled alpha-melanocyte-stimulating hormone analog for microPET imaging of melanocortin 1 receptor expression.
Bioconjug Chem, 2007 May-Jun;18(3):765-72

Cai W, Chen X
Multimodality imaging of vascular endothelial growth factor and vascular endothelial growth factor receptor expression.
Front Biosci, 2007 May 1;12:4267-79

Niu G, Xiong Z, Cheng Z, Cai W, Gambhir SS, Xing L, Chen X
In vivo bioluminescence tumor imaging of RGD peptide-modified adenoviral vector encoding firefly luciferase reporter gene.
Mol Imaging Biol, 2007 May-Jun;9(3):126-34

Hwang T, Han HD, Song CK, Seong H, Kim JH, Chen X, Shin BC
Anticancer Drug-Phospholipid Conjugate for Enhancement of Intracellular Drug Delivery.
Macromol Symp, 2007 Apr 1;249-250(1):109-115

Liu S, Hsieh WY, Jiang Y, Kim YS, Sreerama SG, Chen X, Jia B, Wang F
Evaluation of a (99m)Tc-labeled cyclic RGD tetramer for noninvasive imaging integrin alpha(v)beta3-positive breast cancer.
Bioconjug Chem, 2007 Mar-Apr;18(2):438-46

Hsu AR, Cai W, Veeravagu A, Mohamedali KA, Chen K, Kim S, Vogel H, Hou LC, Tse V, Rosenblum MG, Chen X
Multimodality molecular imaging of glioblastoma growth inhibition with vasculature-targeting fusion toxin VEGF121/rGel.
J Nucl Med, 2007 Mar;48(3):445-54

Cai W, Olafsen T, Zhang X, Cao Q, Gambhir SS, Williams LE, Wu AM, Chen X
PET imaging of colorectal cancer in xenograft-bearing mice by use of an 18F-labeled T84.66 anti-carcinoembryonic antigen diabody.
J Nucl Med, 2007 Feb;48(2):304-10

Zhang X, Chen X
Preparation and characterization of 99mTc(CO)3-BPy-RGD complex as alphav beta3 integrin receptor-targeted imaging agent.
Appl Radiat Isot, 2007 Jan;65(1):70-8

Liu Z, Cai W, He L, Nakayama N, Chen K, Sun X, Chen X, Dai H
In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice.
Nat Nanotechnol, 2007 Jan;2(1):47-52

Veeravagu A, Hsu AR, Cai W, Hou LC, Tse VC, Chen X
Vascular endothelial growth factor and vascular endothelial growth factor receptor inhibitors as anti-angiogenic agents in cancer therapy.
Recent Pat Anticancer Drug Discov, 2007 Jan;2(1):59-71

2006

Cao Q, Cai W, Li T, Yang Y, Chen K, Xing L, Chen X
Combination of integrin siRNA and irradiation for breast cancer therapy.
Biochem Biophys Res Commun, 2006 Dec 22;351(3):726-32

Cai W, Chen K, Mohamedali KA, Cao Q, Gambhir SS, Rosenblum MG, Chen X
PET of vascular endothelial growth factor receptor expression.
J Nucl Med, 2006 Dec;47(12):2048-56

Cai W, Rao J, Gambhir SS, Chen X
How molecular imaging is speeding up antiangiogenic drug development.
Mol Cancer Ther, 2006 Nov;5(11):2624-33

Hsu AR, Hou LC, Veeravagu A, Greve JM, Vogel H, Tse V, Chen X
In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in an orthotopic glioblastoma model.
Mol Imaging Biol, 2006 Nov-Dec;8(6):315-23

Cai W, Wu Y, Chen K, Cao Q, Tice DA, Chen X
In vitro and in vivo characterization of 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrin alpha v beta 3.
Cancer Res, 2006 Oct 1;66(19):9673-81

Cai W, Chen X
Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism.
Anticancer Agents Med Chem, 2006 Sep;6(5):407-28

Dayam R, Aiello F, Deng J, Wu Y, Garofalo A, Chen X, Neamati N
Discovery of small molecule integrin alphavbeta3 antagonists as novel anticancer agents.
J Med Chem, 2006 Jul 27;49(15):4526-34

Cai W, Zhang X, Wu Y, Chen X
A thiol-reactive 18F-labeling agent, N-[2-(4-18F-fluorobenzamido)ethyl]maleimide, and synthesis of RGD peptide-based tracer for PET imaging of alpha v beta 3 integrin expression.
J Nucl Med, 2006 Jul;47(7):1172-80

Wu Y, Cai W, Chen X
Near-infrared fluorescence imaging of tumor integrin alpha v beta 3 expression with Cy7-labeled RGD multimers.
Mol Imaging Biol, 2006 Jul-Aug;8(4):226-36

Chen X, Gambhir SS
Significance of one-bead-one-compound combinational chemistry.
Nat Chem Biol, 2006 Jul;2(7):351-2

Cheng Z, Levi J, Xiong Z, Gheysens O, Keren S, Chen X, Gambhir SS
Near-infrared fluorescent deoxyglucose analogue for tumor optical imaging in cell culture and living mice.
Bioconjug Chem, 2006 May-Jun;17(3):662-9

Cai W, Shin DW, Chen K, Gheysens O, Cao Q, Wang SX, Gambhir SS, Chen X
Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects.
Nano Lett, 2006 Apr;6(4):669-76

Yang YS, Zhang X, Xiong Z, Chen X
Comparative in vitro and in vivo evaluation of two 64Cu-labeled bombesin analogs in a mouse model of human prostate adenocarcinoma.
Nucl Med Biol, 2006 Apr;33(3):371-80

Zhang X, Cai W, Cao F, Schreibmann E, Wu Y, Wu JC, Xing L, Chen X
18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer.
J Nucl Med, 2006 Mar;47(3):492-501

Cao F, Lin S, Xie X, Ray P, Patel M, Zhang X, Drukker M, Dylla SJ, Connolly AJ, Chen X, Weissman IL, Gambhir SS, Wu JC
In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery.
Circulation, 2006 Feb 21;113(7):1005-14

Chen X
Multimodality imaging of tumor integrin alphavbeta3 expression.
Mini Rev Med Chem, 2006 Feb;6(2):227-34

Xiong Z, Cheng Z, Zhang X, Patel M, Wu JC, Gambhir SS, Chen X
Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living mice with mutant herpes simplex virus type 1 thymidine kinase PET reporter gene.
J Nucl Med, 2006 Jan;47(1):130-9

Zhang X, Xiong Z, Wu Y, Cai W, Tseng JR, Gambhir SS, Chen X
Quantitative PET imaging of tumor integrin alphavbeta3 expression with 18F-FRGD2.
J Nucl Med, 2006 Jan;47(1):113-21

Chen X, Park R, Khankaldyyan V, Gonzales-Gomez I, Tohme M, Moats RA, Bading JR, Laug WE, Conti PS
Longitudinal microPET imaging of brain tumor growth with F-18-labeled RGD peptide.
Mol Imaging Biol, 2006 Jan-Feb;8(1):9-15

2005

Cai W, Sam Gambhir S, Chen X
Multimodality tumor imaging targeting integrin alphavbeta3.
Biotechniques, 2005 Dec;39(6 Suppl):S14-25

Cheng Z, Wu Y, Xiong Z, Gambhir SS, Chen X
Near-infrared fluorescent RGD peptides for optical imaging of integrin alphavbeta3 expression in living mice.
Bioconjug Chem, 2005 Nov-Dec;16(6):1433-41

Wu Y, Zhang X, Xiong Z, Cheng Z, Fisher DR, Liu S, Gambhir SS, Chen X
microPET imaging of glioma integrin {alpha}v{beta}3 expression using (64)Cu-labeled tetrameric RGD peptide.
J Nucl Med, 2005 Oct;46(10):1707-18

Kang KW, Min JJ, Chen X, Gambhir SS
Comparison of [14C]FMAU, [3H]FEAU, [14C]FIAU, and [3H]PCV for monitoring reporter gene expression of wild type and mutant herpes simplex virus type 1 thymidine kinase in cell culture.
Mol Imaging Biol, 2005 Jul-Aug;7(4):296-303

Chen X, Sievers E, Hou Y, Park R, Tohme M, Bart R, Bremner R, Bading JR, Conti PS
Integrin alpha v beta 3-targeted imaging of lung cancer.
Neoplasia, 2005 Mar;7(3):271-9

Chen X, Plasencia C, Hou Y, Neamati N
Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery.
J Med Chem, 2005 Feb 24;48(4):1098-106

2004

Chen X, Conti PS, Moats RA
In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in brain tumor xenografts.
Cancer Res, 2004 Nov 1;64(21):8009-14

Chen X, Hou Y, Tohme M, Park R, Khankaldyyan V, Gonzales-Gomez I, Bading JR, Laug WE, Conti PS
Pegylated Arg-Gly-Asp peptide: 64Cu labeling and PET imaging of brain tumor alphavbeta3-integrin expression.
J Nucl Med, 2004 Oct;45(10):1776-83

Chen X, Liu S, Hou Y, Tohme M, Park R, Bading JR, Conti PS
MicroPET imaging of breast cancer alphav-integrin expression with 64Cu-labeled dimeric RGD peptides.
Mol Imaging Biol, 2004 Sep-Oct;6(5):350-9

Chen X, Park R, Hou Y, Khankaldyyan V, Gonzales-Gomez I, Tohme M, Bading JR, Laug WE, Conti PS
MicroPET imaging of brain tumor angiogenesis with 18F-labeled PEGylated RGD peptide.
Eur J Nucl Med Mol Imaging, 2004 Aug;31(8):1081-9

Chen X, Park R, Hou Y, Tohme M, Shahinian AH, Bading JR, Conti PS
microPET and autoradiographic imaging of GRP receptor expression with 64Cu-DOTA-[Lys3]bombesin in human prostate adenocarcinoma xenografts.
J Nucl Med, 2004 Aug;45(8):1390-7

Chen X, Tohme M, Park R, Hou Y, Bading JR, Conti PS
Micro-PET imaging of alphavbeta3-integrin expression with 18F-labeled dimeric RGD peptide.
Mol Imaging, 2004 Apr;3(2):96-104

Chen X, Park R, Shahinian AH, Tohme M, Khankaldyyan V, Bozorgzadeh MH, Bading JR, Moats R, Laug WE, Conti PS
18F-labeled RGD peptide: initial evaluation for imaging brain tumor angiogenesis.
Nucl Med Biol, 2004 Feb;31(2):179-89

Chen X, Park R, Tohme M, Shahinian AH, Bading JR, Conti PS
MicroPET and autoradiographic imaging of breast cancer alpha v-integrin expression using 18F- and 64Cu-labeled RGD peptide.
Bioconjug Chem, 2004 Jan-Feb;15(1):41-9

Chen X, Park R, Shahinian AH, Bading JR, Conti PS
Pharmacokinetics and tumor retention of 125I-labeled RGD peptide are improved by PEGylation.
Nucl Med Biol, 2004 Jan;31(1):11-9

2002

Ren X, Meng Q, Song Y, Hu C, Lu C, Chen X, Xue Z
Unusual magnetic property associated with dimerization within a nickel tetramer.
Inorg Chem, 2002 Nov 18;41(23):5931-3

Ren X, Meng Q, Song Y, Lu C, Hu C, Chen X
Unusual magnetic properties of one-dimensional molecule-based magnets associated with a structural phase transition.
Inorg Chem, 2002 Nov 4;41(22):5686-92

Ren X, Wu P, Zhang W, Meng Q, Chen X
Synthesis, crystal structure and magnetic properties of [RbzPy] [Fe(mnt)2] complexes ([RbzPy]+ = 1-(4’-R-benzyl)pyridinium, R = NO2 and Cl; mnt2 = maleonitriledithiolate)
Transition Met Chem 2002;27:394-7.

2001

Chen X, Femia FJ, Babich JW, Zubieta J
Schiff base chemistry of the rhenium(V)-oxo core with '3+2' ligand donor sets.
Inorganica Chim Acta, 2001 May;316(1-2):33-40

Chen X, Femia FJ, Babich JW, Zubieta J
Synthesis and structural characterization of rhenium(I) tricarbonyl complexes with the bidentate ligands o-(diphenylphosphino)benzaldehyde (PnO) and o-[(diphenylphosphino)benzylidene]analine (PnN).
Inorganica Chim Acta, 2001 Apr 27;315(2):147-152

Chen X, Femia FJ, Babich JW, Zubieta J
Synthesis, characterization and crystal structures of mono-, di- and trinuclear rhenium(I) tricarbonyl complexes with 2,3,5,6-tetra(2-pyridyl)pyrazine.
Inorganica Chim Acta, 2001 Apr 16;315(1):66-72

Chen X, Femia FJ, Babich, JW, Zubieta J
Rhenium(I) carbonyl complexes of 2,4,6-tris(2-pyridyl)-1,3,5-triazine (TPT). Rhenium (I)-promoted methoxylation of the triazine ring carbon atom in dinuclear rhenium complexes
Inorg Chem 2001;40:2769-77.

Femia FJ, Chen X, Babich JW, Zubieta J
Synthesis and characterization of a '3+2' {Re(V)O}3+ core complex carrying the ONS/PO donor atom set
Inorg Chim Acta 2001;316:145-8.

Chen X, Femia FJ, Babich, JW, Zubieta J
Spectroscopic and structural studies of complexes of the fac-[Re(N∩N)(CO)3L]n+ type (N∩N=2-(2-pyridyl)benzothiazole; L=Cl, Br, CF3SO3–, CH3CN)
Inorg Chim Acta 2001;314:91-6.

2000

Chen X, Femia FJ, Babich JW, Zubieta J
An unexpected '4+2' [N(3)S]:[NS] rhenium(IV) complex formed upon cleavage of a Re(V) imido bond.
Inorganica Chim Acta, 2000 Dec 15;310(2):237-241

Femia FJ, Chen X, Maresca KP, Babich JW, Zubieta J
Syntheses and structural characterization of rhenium-bis-hydrazinopyrimidine core complexes with thiolate and Schiff base coligands.
Inorganica Chim Acta, 2000 Dec 15;310(2):210-216

Chen X, Femia FJ, Babich JW, Zubieta J
The syntheses and structures of '3+2' and '2+2+1' oxorhenium mixed-ligand complexes employing 8-hydroxy-5-nitroquinoline as the bidentate N,O donor ligand.
Inorganica Chim Acta, 2000 Oct 20;308(1-2):80-90

Chen X, Femia FJ, Babich JW, Zubieta J
Schiff base chemistry of the {ReO} core: structural characterization of the unusual '3 + 2' complex [ReO(eta-OC(6)H(4)-CH=NC(6)H(4)-2-S)(eta-OC(6)H(4))].
Inorganica Chim Acta, 2000 Sep 11;307(1-2):149-153

Chen X, Femia FJ, Babich JW, Zubieta J
Exploring oxorhenium '3+1' mixed-ligand complexes carrying the S-benzyl-3-[(2-hydroxyphenyl)methylene]dithiocarbazate [ONS]/monothiol [S] donor set: synthesis and characterization.
Inorganica Chim Acta, 2000 Sep 11;307(1-2):154-159

Femia FJ, Chen X, Maresca KP, Babich JW, Zubieta J
Synthesis and crystal and molecular structure of a tetranuclear cluster based on the rhenium(III)-bisorganohydrazino core: [Re(HNNC(4)H(3)N(2))(NNC(4)H(3)N(2))(OCH(3))(2)](4).
Inorganica Chim Acta, 2000 Sep 1;307(1-2):160-163

Chen X, Femia FJ, Babich JW, Zubieta J
Synthesis and characterization of oxorhenium(V)-'3+1' mixed thiolate [SNS]/[S] and [ONS]/[S] complexes. Crystal and molecular structures of [ReO(eta-SCH(2)C(5)H(3)NCH(2)S)(eta-C(6)H(4)Br-4-S)], [ReO(eta-SCH(2)C(5)H(3)NCH(2)O)(eta-C(6)H(4)X-4-S)] (X=Cl, OMe), [ReO(eta-SCH(2)C(5)H(3)NCH(2)O)(eta-C(6)H(4)OCH(3)-4-CH(2)S)] and [ReO(eta-SCH(2)C(5)H(3)NCH(2)S)(eta-C(5)H(4)NH-2-S)][Cl].
Inorganica Chim Acta, 2000 Sep 1;307(1-2):88-96

Chen X, Femia FJ, Babich JW, Zubieta J
Investigations of the {ReO} core: A '2+2' complex from bidentate and potentially trident ligands: [ReO(?-HOC(6)H(4)-2-CH(2)NC(6)H(4)S)(?-SC(5)H(4)N)(PPh(3))].
Inorganica Chim Acta, 2000 Aug 11;306(1):38-41

Chen X, Femia FJ, Babich JW, Zubita J
Structural characterizations of an Re(IV) complex [ReCl(4)(OPPh(3))(2)] and of an imino species [ReOCl(2)(PPh(3))(eta-OC(6)H(4)-2-CH=NH)] prepared from the reaction of [ReOCl(3)(PPh(3))(2)] with salicylaldoxime.
Inorganica Chim Acta, 2000 Aug;306(1):112-115

Femia FJ, Chen X, Maresca KP, Shoup TM, Babich JW, Zubieta J
Synthesis and characterization of complexes of the {ReO} core with SNS and S donor ligands.
Inorganica Chim Acta, 2000 Aug;306(1):30-37

Femia FJ, Chen X, Babich JW, Zubieta J
Oxorhenium(V) complexes containing tridentate Schiff-base and monothiol coligands.
Inorganica Chim Acta, 2000 Apr 20;300-302:517-524

1999

Chen X, Ji M, Fisher DR, Wai CM
Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225.
Synlett, 1999 Sep 1;11:1784-1786

Wai CM, Kulyako Y, Yak HK, Chen X, Lee SJ
Selective extraction of strontium with supercritical fluid carbon dioxide.
Chem Commun (Camb), 1999;(24):2533-2534

Zhan S, Chen X, Vij A, Guo D, Meng Q.
Synthesis, studies and molecular structure of trinuclear cyanide-bridged copper-iron complexes
Inorg Chim Acta 1999;292(2):157-62.

Zhan S, Hu C, Chen X, Meng Q, Lu C, Wang G, Zheng P.
Synthesis, structure, spectral and magnetic properties of a dinuclear copper(II)/nickel(II) complex bridged by glyoximate groups
Polyhedron 1999;18(15):2035-9.

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Last Updated On 07/11/2012