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Asthma Clinical Research Network (ACRN) Measuring Inhaled Corticosteroid Efficacy (MICE)

Clinical Trials URL:
Study Type: Clinical Trial
Prepared on October 13, 2008
Last Updated on August 24, 2006
Study Dates: 1999-2000
Consent: Unrestricted Consent
Commercial Use Restrictions: No
NHLBI Division: DLD
Collection Type: Open BioLINCC Study - See bottom of this webpage for request information


The purpose of this study was to compare the relative benficial and systemic effects in a dose-response relationship for 2 ICSs.


A clinical model is needed to compare inhaled corticosteriods (ICS) with respect to efficacy.


30 asthmatic individuals 18 to 55 years of age. this was a feasibility study, not a comparative trial, therefore the sample size calcualtion was based on an appropriate sample size for extimating the common variance with som elevel of precision.


High-dose ICS therapy did not significantly increase the efficacy of measures that were evaluated but it did increase the systemic effect measure, overnight cortisol secretion.