PREVENT Cancer Preclinical Drug Development Program

Funded Projects

Breast Cancer (vaccine)

• Plac1 vaccine for breast cancer prevention
• Efficacy of a multi-antigen vaccine in the prevention of methynitrosourea-induced mammary cancers (ER+) in female Sprague-Dawley rats

Breast Cancer (small molecules and biomarkers)

• Chemopreventive effects in both standard chow diets and high-fat diets of known positive- and negative-chemopreventive agents employing both high-risk (but histologically normal) mammary epithelium and mammary cancers including correlative biomarkers
• Blood-based markers of obesity-induced breast inflammation

Colon Cancer (small molecules)

• Preclinical development of mPGES-1 and 5-LOX selective inhibitors for colon cancer chemoprevention
• Combination of aspirin and omeprazole for colon cancer chemoprevention
• Efficacy of aspirin and naproxen (short-term frequent dosing) in colorectal cancer models

Colon Cancer (vaccine)

• Characterization of potential antigens for immunization against colon cancer and testing multivalent tumor vaccines in min mice

Lung Cancer (small molecules)

• In vivo evaluation of a chemopreventive agent, Ciclesonide, in mouse lung tumor model by inhalation
• Anti-inflammatory effects of fixed-dose combinations of pioglitazone and metformin for lung cancer prevention

Lung Cancer (biomarker)

• Modulation of cigarette smoke-induced alterations of microRNA expression and lung tumors in mice treated with aspirin and naproxen

Skin Cancer (small molecule)

• Repurposing itraconazole for topical treatment of basal cell carcinoma in patients with basal cell nevus syndrome