September 2

Introduction to course

Introduction Slides (1 slide per page) (621 KB)
Introduction Slides (3 slides per page) (474 KB)
Introduction Slides (Text-Only) (266 KB)

Video of Introduction to course from lecture with caption (Adobe Connect Link)

J. Lertora
(NIH/CC)

MODULE 1: PHARMACOKINETICS

September 9

Clinical pharmacokinetics

Clinical Pharmacokinetics Slides (1 slide per page) (597 KB)
Clinical Pharmacokinetics Slides (3 slides per page) (423 KB)
Clinical Pharmacokinetics Slides (Text-Only) (255 KB)

Video of Clinical pharmacokinetics from lecture with caption (Adobe Connect Link)

J. Lertora
(NIH/CC)

September 16

Chemical assay of drugs and drug metabolites

Chemical Assay Slides (1 slide per page) (1.32 MB)
Chemical Assay Slides (3 slides per page) (829 KB)
Chemical Assay Slides (Text-Only) (328 KB)

Video of Chemical assay of drugs and drug metabolites lecture with caption (Adobe Connect Link)

S. Markey
(NIH/NIMH)

September 23

Compartmental analysis of drug distribution

Compartmental analysis of drug distribution slides (1 slide per page) (703 KB)
Compartmental analysis of drug distribution slides (3 slides per page) (466 KB)
Compartmental analysis of drug distribution slides (Text-Only) (289 KB)

Video of compartmental analysis of drug distribution lecture with caption (Adobe Connect Link)

J. Lertora
(NIH/CC)

September 30

Drug absorption and bioavailability

Drug absorption and bioavailability slides (1 slide per page) (1 MB)
Drug absorption and bioavailability slides (3 slides per page) (663 KB)
Drug absorption and bioavailability slides (Text-Only) (196 KB)

Video of drug absorption and bioavailability lecture with caption (Adobe Connect Link)

J. Lertora
(NIH/CC)

October 7

Use of positron emission tomography (PET) in pharmacokinetics

Positron Emission Tomography slides (1 slide per page) (998 KB)
Positron Emission Tomography slides (3 slides per page) (551 KB)
Positron Emission Tomography slides (Text-Only) (280 KB)

Video of Positron emission tomography (PET) lecture with caption (Adobe Connect Link)

R. Innis
(NIH/NIMH)

October 14

Effects of renal disease on pharmacokinetics

Effects of renal disease on pharmacokinetics (1 slide per page) (498 KB)
Effects of renal disease on pharmacokinetics (3 slides per page) (443 KB)
Effects of renal disease on pharmacokinetics (Text-Only) (316 KB)

Video of Effects of Renal Disease on Pharmacokinetics lecture with caption (Adobe Connect Link)

J. Lertora
(NIH/CC)

October 21

SPECIAL LECTURE: Pharmacokinetics in patients requiring renal replacement therapy

Pharmacokinetics in patients requiring renal replacement therapy (Dr. Atkinsons's slides - 1 slide per page) (670 KB)
Pharmacokinetics in patients requiring renal replacement therapy (Dr. Atkinsons's slides - 3 slides per page) (434 KB)
Pharmacokinetics in patients requiring renal replacement therapy (Dr. Atkinsons's slides - Text-only) (278 KB)

Pharmacokinetics in patients requiring renal replacement therapy (Dr. Susla's slides - 1 slide per page) (1.16 MB)
Pharmacokinetics in patients requiring renal replacement therapy (Dr. Susla's slides - 3 slides per page) (649 KB)
Pharmacokinetics in patients requiring renal replacement therapy (Dr. Susla's slides - Text-only) (351 KB)

Video of pharmacokinetics in patients requiring hemodialysis lecture with caption (Adobe Connect Link)

A. Atkinson
(Northwestern University)

G. Susla
(MedImmune, Inc)

October 28

Noncompartmental vs. compartmental approaches to PK analysis

Noncompartmental vs. compartmental approaches to PK analysis (1 slide per page) (1,676 KB)
Noncompartmental vs. compartmental approaches to PK analysis (3 slides per page) (583 KB)
Noncompartmental vs. compartmental approaches to PK analysis (Text-only) (528 KB)

Video of noncompartmental vs. compartmental approaches to PK data analysis lecture with caption  (Adobe Connect Link)

P. Vicini
(Pfizer, Inc.)

November 4

Effects of liver disease on pharmacokinetics

Effects of liver disease on pharmacokinetics (1 slide per page) (768 KB)
Effects of liver disease on pharmacokinetics (3 slides per page) (272 KB)
Effects of liver disease on pharmacokinetics (Text-only) (210 KB)

Video of effects of liver disease on pharmacokinetics lecture with caption (Adobe Connect Link)

J. Lertora
(NIH/CC)

November 18

Population pharmacokinetics

Population pharmacokinetics (1 slide per page) (995 KB)
Population pharmacokinetics (3 slides) (940 KB)
Population pharmacokinetics (Text-only) (206 KB)

Video of population pharmacokinetics lecture with caption (Adobe Connect Link)

R. Miller
(Daiichi Sankyo, Inc.)

MODULE 2: DRUG METABOLISM AND TRANSPORT

December 2

Pathways of drug metabolism

Pathways of drug metabolism (1 slide per page) (910 KB)
Pathways of drug metabolism (3 slides per page) (690 KB)
Pathways of drug metabolism (Text-only) (305 KB)

Video of pathways of drug metabolism lecture with caption (Adobe Connect Link)

S. Markey
(NIH/NIMH)

December 9

Drug Interactions

Drug Interactions (1 slide per page) (3.74 MB)
Drug Interactions (3 slides per page) (1.74 MB)
Drug Interactions (Text-only) (209 KB)

Video of drug interactions lecture with caption (Adobe Connect Link)

S. Penzak
(NIH/CC)

December 16

Pharmacogenomics

Pharmacogenomics (1 slide per page) (1.23 MB)
Pharmacogenomics (3 slides per page) (725 KB)
Pharmacogenomics (Text-only) (630 KB)

Video of pharmacogenetics lecture with caption (Adobe Connect Link)

D. Flockhart
(IUPUI)

January 7

Biochemical mechanisms of drug toxicity

Biochemical mechanisms of drug toxicity from previous year (1 slide per page) (707 KB)
Biochemical mechanisms of drug toxicity from previous year (3 slides per page) (231 KB)
Biochemical mechanisms of drug toxicity from previous year (Text-only) (165 KB)

Video of Biochemical mechanisms of drug toxicity lecture with caption (Adobe Connect Link)

L. Pohl
(NIH/NHLBI)

January 13

SPECIAL LECTURE: P-glycoprotein and drug transport

• Dr. Gottesman: SPECIAL LECTURE: P-glycoprotein and drug transport (1 slide per page) (1.42 MB)
• Dr. Gottesman: SPECIAL LECTURE: P-glycoprotein and drug transport (3 slides per page) (1.12 MB)
• Dr. Gottesman: SPECIAL LECTURE: P-glycoprotein and drug transport (Text-only) (544 KB)
• Dr. Innis: SPECIAL LECTURE: P-glycoprotein and drug transport (1 slide per page) (1.03 MB)
• Dr. Innis: SPECIAL LECTURE: P-glycoprotein and drug transport (3 slides per page) (851 KB)
• Dr. Innis: SPECIAL LECTURE: P-glycoprotein and drug transport (Text-only) (699 KB)
  
  Video of P-glycoprotein and drug transport lecture with caption by Drs. M Gottesman and R. Innis (Adobe Connect Link)

M. Gottesman
(NIH/OIR)

R. Innis
(NIH/NIMH)

January 20

Equilibrative and concentrative transport

Equilibrative and concentrative transport (1 slide per page) (3.32 MB)
Equilibrative and concentrative transport (3 slides per page) (1.76 MB)
Equilibrative and concentrative transport (Text-only) (334 KB)

Video of Equilibrative and concentrative transport lecture with caption (Adobe Connect Link)

J. Ware
(Genentech, Inc.)

MODULE 3: ASSESSMENT OF DRUG EFFECTS:

January 27

Dose response and concentration response analysis

Dose response and concentration response analysis (1 slide per page) (2.93 MB)
Dose response and concentration response analysis (3 slides per page) (1.20 MB)
Dose response and concentration response analysis (Text-only) (145 KB)

Video of Dose response and concentration response analysis lecture with caption (Adobe Connect Link)

J. Lertora
(NIH/CC)

February 3

Disease progression models and clinical trial simulation

Disease progression models and clinical trial simulation (1 slide per page) (2.53 MB)
Disease progression models and clinical trial simulation (3 slides per page) (2.26 MB)
Disease progression models and clinical trial simulation (Text-only) (287 KB)

Video of disease progression models and clinical trial simulation lecture from previous year (Adobe Connect Link)

D. Mould
(Projections Research,Inc.)

February 10

Physiological and laboratory markers of drug effect

Physiological and laboratory markers of drug effect (1 slide per page) (538 KB)
Physiological and laboratory markers of drug effect (3 slides per page) (566 KB)
Physiological and laboratory markers of drug effect (Text-only) (204 KB)

Video of physiological and laboratory markers of drug effect lecture with caption from previous year (Adobe Connect Link)

J. Woodcock
(FDA/CDER)

MODULE 4: Optimizing and Evaluating Patient Therapy

February 17

Drug therapy in pregnant and nursing women

Drug therapy in pregnant and nursing women (1 slide per page) (1.86 MB)
Drug therapy in pregnant and nursing women (3 slides per page) (1.53 MB)
Drug therapy in pregnant and nursing women (Text-only) (185 KB)

Video of drug therapy in pregnant and nursing women lecture with caption (Adobe Connect Link)

M. Frederiksen
(Northwestern University)

February 24

Drug therapy in the elderly

Pharmacodynamics: Drug Therapy in the Elderly (1 slide per page) (3.46 MB)
Pharmacodynamics: Drug Therapy in the Elderly (3 slides per page) (1.16 MB)
Pharmacodynamics: Drug Therapy in the Elderly (Text-only) (162 KB)

Video of drug therapy in the elderly lecture with caption (Adobe Connect Link)

D. Abernethy
(FDA)

March 3

Clinical analysis of adverse drug reactions

Clinical analysis of adverse drug reactions (1 slide per page) (705 KB)
Clinical analysis of adverse drug reactions (3 slides per page) (387 KB)
Clinical analysis of adverse drug reactions (Text-only) (435 KB)

Video of clinical analysis of adverse drug reactions lecture with caption (Adobe Connect Link)

C. Chamberlain
(NIH/CC)

March 10

Developmental and pediatric pharmacology

Developmental and pediatric pharmacology from previous year (1 slide per page) (1.69 MB)
Developmental and pediatric pharmacology from previous year (3 slides per page) (1.04 MB)
Developmental and pediatric pharmacology from previous year (Text-only) (203 KB)

Video of developmental and pediatric pharmacology lecture with caption from previous year (Adobe Connect Link)

J. van den Anker (Children's National Medical Center)

March 17

Quality assessment of drug therapy

Quality assessment of drug therapy from previous year (1 slide per page) (436 KB)
Quality assessment of drug therapy from previous year (3 slides per page) (318 KB)
Quality assessment of drug therapy from previous year (Text-only) (182 KB)

Video of quality assessment of drug therapy lecture with caption from previous year (Adobe Connect Link)

C. Daniels
(UCSD)

MODULE 5: DRUG DISCOVERY AND DEVELOPMENT

March 24

Pre-clinical drug development

Pre-clinical drug development from previous year (One slide per page) (801 KB)
Pre-clinical drug development from previous year (Three slides per page) (514 KB)
Pre-clinical drug development from previous year (Text-only) (365 KB)

Video of pre-clinical drug development lecture with caption from previous year (Adobe Connect Link)

C. Takimoto
(Centocor R&D, Inc., Johnson & Johnson)

March 31

Drug discovery

Drug discovery from previous year (One slide per page) (2.08 MB)
Drug discovery from previous year (Three slides per page) (1.11 MB)
Drug discovery from previous year (Text-only) (527 KB)

Video of drug discovery lecture with caption from previous year (Adobe Connect Link)

E. Sausville
(UMMS)

April 7

Animal scale up and Phase I studies

Dedrick: Animal scale up and Phase I studies from previous year (One slide per page) (1.0 MB)
Dedrick: Animal scale up and Phase I studies from previous year (Three slides per page) (407 KB)
Dedrick: Animal scale up and Phase I studies from previous year (Text-only) (82 KB)

Collins: Animal scale up and Phase 1 studies from previous year (One slide per page) (655 KB)
Collins: Animal scale up and Phase 1 studies from previous year (Three slides per page) (450 KB)
Collins: Animal scale up and Phase 1 studies from previous year (Text-only)  (186 KB)

Video of Animal scale up and Phase I studies lecture with caption from previous year (Adobe Connect Link)

R. Dedrick
(NIH/NIBIB)

J. Collins
(NIH/NCI)

April 14

Pharmacokinetics of biotechnology products and large molecules

Pharmacokinetics of biotechnology products and large molecules from previous year (One slide per page) (1.08 MB)
Pharmacokinetics of biotechnology products and large molecules from previous year (Three slides per page) (609 KB)
Pharmacokinetics of biotechnology products and large molecules from previous year (Text-only) (474 KB)

Video of pharmacokinetics of biotechnology products and large molecules lecture with caption from previous year (Adobe Connect Link)

P. Garzone
(PD3G Consulting)

April 21

Role of the FDA in guiding drug development

Role of the FDA in guiding drug development from previous year (One slide per page) (398 KB)
Role of the FDA in guiding drug development from previous year (Three slides per page) (308 KB)
Role of the FDA in guiding drug development from previous year (Text-only) (619 KB)

Video of role of the FDA in guiding drug development lecture with caption from previous year (Adobe Connect Link)

C. Peck
(CDDS, UCSF)

April 28

Design of clinical drug development programs

Design of clinical drug development programs from previous year (One slide per page) (1.91 KB)
Design of clinical drug development programs from previous year (Three slides per page) (769 KB)
Design of clinical drug development programs from previous year (Text-only) (362 KB)

Video of design of clinical drug development program lecture with caption from previous year (Adobe Connect Link)

C. Breder
(FDA)