Cancer Pharmacogenomics: Integrating Discoveries in Basic, Clinical and Population Sciences to Advance Predictive Cancer Care
The Trans-NCI Pharmacogenomics and Pharmacoepidemiology Working Group (PPWG) and Division of Cancer Control and Population Sciences (DCCPS) sponsored the workshop “Cancer Pharmacogenomics: Integrating Discoveries in Basic, Clinical and Population Sciences to Advance Predictive Cancer Care” on October 28, 2010 in Bethesda, MD. The meeting brought together experts from various disciplines in the cancer and pharmacology research communities to discuss how a comprehensive and integrated scientific approach to cancer pharmacogenimics research can be used to accelerate discoveries in predictive cancer medicine to application. The goal of this Workshop was to examine how discoveries in basic, clinical and population sciences can build upon each other to advance the science and how this can be facilitated by multidisciplinary collaborations and partnerships.
The workshop was organized by Andrew N. Freedman, Ph.D., Chair of the PPWG, and Chief, Clinical and Translational Epidemiology Branch (CTEB) in the Epidemiology and Genetics Research Program (EGRP), DCCPS, and Leah B. Sansbury, Ph.D., M.S.P.H., Co-Chair of PPWG’s Population Sciences Sub-Group, and Program Director, CTEB.
AGENDA
Thursday, October 28, 2010
7:30 a.m. - 5:30 p.m.
Pooks Hill Marriott
Bethesda, MD
7:30 a.m. – 8:00 a.m. | Registration and Continental Breakfast |
8:00 a.m. – 8:20 a.m. |
Welcome and Introduction
Jeffrey S. Abrams, M.D. |
8:20 a.m. – 8:45 a.m. |
Workshop Overview and Objectives Andrew N. Freedman, Ph.D. |
Moderator: William D. Figg, M.D. | |
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8:45 a.m. – 9:10 a.m. |
James N. Ingle, M.D. Mayo Clinic Using retrospective analysis of RCTs to discover germline pharmacogenomic (PGx) markers of treatment toxicity: The example of a genome-wide association (GWAS) study in patients experiencing musculoskeletal adverse events on aromatase inhibitors as adjuvant therapy in early breast cancer entered on NCIC CTG Trial MA.27 |
9:10 a.m. – 9:35 a.m. |
Daniel F. Hayes, M.D. University of Michigan Using retrospective analysis of RCTs to discover and validate somatic PGx markers of treatment response |
9:35 a.m. – 10:00 a.m. |
Mary V. Relling, M.D. St. Jude Children's Research Hospital Using retrospective analysis of RCTs to discover and validate germline PGx markers of treatment response: The example of a GWAS of germline variation associated with treatment response in childhood acute lymphoblastic leukemia |
10:00 a.m. – 10:15 a.m. | Break |
Moderator: Lori Minasian, M.D. | |
10:15 a.m. – 10:35 a.m. |
Roy Herbst, M.D. M.D. Anderson Cancer Center Conducting genome-guided prospective RCTs to identify and validate PGx markers of treatment response: The example of the BATTLE lung cancer trial |
10:35 a.m. – 10:45 a.m. |
Richard Schilsky, M.D. University of Chicago IOM Cancer Clinical Trials Report and Implications for Pharmacogenomic Research |
10:45 a.m. – 11:10 a.m. |
Panel Discussion
Moderator: Richard L. Schilsky, M.D. Panelists: |
Moderator: Leah Sansbury, Ph.D. | |
11:10 a.m. – 11:35 p.m. |
Bruce Carleton, Ph.D. The Canadian Pharmacogenomic Network for Drug Safety: The example of genetic variants in TPMT and COMT and their association with hearing loss in children receiving cisplatin chemotherapy |
11:35 a.m. – 12:00 p.m. |
Dr. Eileen Dolan, Ph.D. University of Chicago Pharmacogenomic Discovery Using Cell-Based Models |
12:00 p.m. – 1:00 p.m. | Lunch |
Moderator: William D. Figg, M.D. | |
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1:00 p.m. – 1:25 p.m. |
Timothy Yap, M.D. Envisioning the future of early anticancer drug development |
Moderator: Andrew Freedman, Ph.D. | |
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1:25 p.m. – 2:45 p.m. |
Speakers: Felix Frueh M.D. Medco Patricia Deverka, Ph.D. Geoff Liu, M.D. Christine Ambrosone, Ph.D. Richard M. Weinshilboum, M.D. Samir Khleif, M.D. |
2:45 p.m. – 3:00 p.m. | Leah Sansbury, Ph.D. Charge to Priority Setting Sessions |
3:00 p.m. – 3:15 p.m. | Break |
3:15 p.m. – 4:30 p.m. |
Priority Setting Session A: Basic Science and Drug Discovery
Priority Setting Session B: Clinical Science
Priority Setting Session C: Observational Science
Priority Setting Session D: Translation, Knowledge Synthesis and Implementation
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Moderator: Lori Minasian, M.D. | |
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4:30 p.m. – 5:30 p.m. | Session Leaders |