About Breast CFR

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Overview

The Breast CFR includes lifestyle, medical history, and family history data collected from more than 55,000 women and men from 14,000 families with and without breast cancer. The Breast CFR began recruiting families in 1996, and all participants are followed up 10 years after recruitment to update personal and family histories and expand recruitment if new cases have occurred since baseline.

Family Recruitment
  Male Female Unknown Total
Population-based families* 9,003
Case probandsb 87 7,844 0 7,931
Affected relativesb 22 2,365 0 2,387
Unaffected relativesc 10,246 17,964 0 28,210
Control probandsc 0 3,428 0 3,428
Relatives (Australia site only) 4,043 6,497 0 10,540
Total population-based individuals 14,420 38,175 0 52,595
Clinic-based families** 4,034
Affected probandsb 37 2,444 0 2,481
Unaffected probandsc 41 1,373 0 1,414
Affected relativesb 35 1,771 0 1,806
Unaffected relativesc 3,097 5,112 0 8,209
Total clinic-based individuals 3,211 10,799 0 14,010

* Includes population-based case proband families from all sites and population-based control proband families from Australia site.
** Includes all clinic-based proband families (counts family ID of affected and unaffected clinic-based probands).

  1. Enrolled female and male individuals with completed epidemiology questionnaire and/or biospecimen (blood or buccal sample)
  2. Affected with invasive or in-situ breast cancer at baseline interview or biospecimen collection
  3. No history of breast cancer at baseline interview or biospecimen collection

Note: Blood and non-blood relatives/individuals excluding the probands.

Biospecimens Collected

Available Resources
  Male Female Unknown Total
Affected Individualsb Family history/epi dataa,d 137 11,816 0 11,953
Proxy family history/epi data 32 2,309 0 2,341
FFQ datae 115 9,087 0 9,202
Blood/buccal samples 125 10,674 0 10,799
Cell lines 71 5,942 0 6,013
Tumor material 69 3,394 0 3,463
Unaffected Individualsc Family history/epi dataa,d 6,169 20,229 0 26,398
Proxy family history/epi data 10,571 13,238 0 23,809
FFQ datae 3,276 12,440 0 15,716
Blood/buccal samples 3,884 14,203 0 18,087
Cell lines 916 4,251 0 5,167
  1. Baseline data for all population-based and clinic-based individuals, males and females
  2. Affected with invasive or in-situ breast cancer at baseline interview or biospecimen collection
  3. No history of breast cancer at baseline interview or biospecimen collection; includes controls from population-based BCFR sites and unaffected clinic-based probands
  4. Excluding proxy questionnaire completion
  5. Food Frequency Questionnaire

Learn more about Breast CFR

Last Updated: 06 Jun 2012

Division of Cancer Control and Population Sciences National Cancer Institute Department of Health and Human Services National Institutes of Health USA.gov