News

NIGMS-supported researchers have identified the binding sites of microRNAs in one of the foremost model organisms, C. elegans, using biochemical means to capture targeted mRNA sequences in vivo.

NIGMS-funded researchers have discovered a unique role for two RNAs; they organize and maintain a compartment within the nucleus.

NIGMS-funded researchers have discovered a method that uses RNA replicator molecules to detect specific chemicals.

NIGMS-supported scientists have synthesized for the first time RNA enzymes that can indefinitely replicate themselves without the help of proteins or other cellular components.

A team of NIGMS-supported biologists has discovered that two RNA polymerases found only in plants are specialized forms of an enzyme common to all eukaryotic organisms.

New NIGMS-supported research sheds light on possible functions of abundant 'noncoding' RNA molecules.

A team of NIGMS-supported scientists has discovered that a class of small RNAs carries epigenetic information and passes on the trait of fertility from mother to offspring in fruit flies.

NIGMS-supported biologists have made headway in explaining a mechanism by which plant cells silence potentially harmful genes.

NIGMS-supported researchers have shown that a phenomenon known as alternative splicing varies more between tissues than was previously believed.

NIGMS-funded researchers have discovered that microRNAs, which help regulate genes, have been around since the earliest of animal lineages.

A team funded by the NIGMS has developed a user-friendly, interactive database, granting unprecedented access to information on genes involved in cell migration. 

An NIGMS-funded study probes how interfering RNA molecules allow DNA expression patterns to be inherited.

The Nobel Prize in physiology or medicine was awarded to NIGMS grantees Andrew Z. Fire and Craig C. Mello for their discovery of "RNA interference – gene silencing by double-stranded RNA."

The Nobel Prize in Physiology or Medicine for 2006 has been awarded to longtime NIGMS grantees Andrew Fire and Craig Mello for their discoveries related to RNA interference.

Andrew Z. Fire and Craig C. Mello won the physiology or medicine prize for their discovery of RNA interference, a mechanism of gene silencing.

NIGMS grantees Andrew Fire and Craig Mello have been awarded the 2006 Nobel Prize in Physiology or Medicine for their discovery of RNA interference.

Craig Mello and his colleague Andrew Fire, both long-time NIGMS grantees, have been awarded the 2006 Nobel Prize in Physiology or Medicine.

NIGMS-supported researchers have jumped a significant hurdle in the use of RNA interference (RNAi), a commonly used molecular tool. They have developed a simple way to use RNAi to silence a selected gene in a specific tissue in mice.

NIGMS-supported scientists have gotten their first detailed look at the molecular structure of an enzyme that nature has been using for eons to help silence unwanted genetic messages.

An NIGMS-funded research team has identified 80 new genes essential to the process of RNA interference, a powerful new research tool for inactivating genes in plants or animals.

An NIGMS-supported study has used RNA interference to identify fruit fly genes involved in the innate immune response, our body's first line of defense against invading microbes.

NIGMS-supported scientists have recently patented RNA interference (RNAi), a technique for silencing the activity of targeted genes. The method has been widely licensed in the U.S., Japan and Europe to address a broad range of research questions.

Science magazine had declared advances in understanding molecules called "small RNAs" as the top scientific achievement of 2002. A number of the advances were supported by NIGMS.

Two independent research groups—one supported by NIGMS—have discovered that the fruit fly version of the human fragile X mental retardation protein associates with components of the RNAi pathway, suggesting that an RNAi-related process may underlie the syndrome. 

In a recent study NIGMS-supported researchers report a new technique that can "silence" or knock-down the production of specific proteins in mammalian cells.

Researchers supported by NIGMS have successfully co-opted a natural cellular mechanism to shut down the activity of specific genes in mammalian cells cheaply and efficiently.

NIGMS-supported scientists report a new technique for carrying out genetic analysis directly in mammalian cells. The technique has the potential to greatly simplify gene manipulation and gene discovery for many biomedical applications.

NIGMS-supported developmental biologists have used RNAi to reveal a biological function for a mysterious protein that may play a role in the growth of tumors.