PGRN Vision
To lead discovery and advance translation in genomics in order to enable safer and more effective drug therapies.
Major Indicators of Success
- Discovery of novel insights into mechanisms relating genomic variation to differences in drug responses
- Demonstration of the use and utility of genomic information to improve outcomes for drug therapies
- Incorporation of genomic data to predict and personalize medicine use into routine clinical practice
PGRN Mission
The PGRN investigators, individually and collectively, will:
- Implement studies in basic, translational and clinical science to advance the scientific vision
- Develop novel experimental methods and tools to solve pharmacogenomic problems
- Share data and, where feasible, biological samples in collaborations
- Foster cross-disciplinary teams for discovery and dissemination of new information
- Build effective partnerships and alliances with key stakeholders outside the PGRN
- Engage related disciplines to advance the application of pharmacogenomic knowledge
- Work cooperatively so that the network becomes more than the sum of the parts
PharmGKB Mission
The Pharmacogenomics Knowledge Base is a research tool and will:
- Disseminate knowledge about the impact of human genetic variation on drug responses
- Curate and display primary genotype and phenotype data
- Annotate gene variants and gene-drug-disease relationships via literature reviews
- Summarize important pharmacogenomic genes and drug pathways
- Enable consortia examining important questions in pharmacogenomics