Specific Gut Bacteria Linked to Metabolic Syndrome |
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August 15, 2012 • University of Maryland |
UF Delivers Promise of Personalized Medicine to Heart Patients |
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June 25, 2012 • University of Florida |
Statistical Method Estimates to What Extent Widespread Heritable Components Contribute to the Risk of Four Common Diseases |
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March 25, 2012 • Brigham and Women's Hospital |
Personalized "Omics" Profile Allows Scientist to Discover, Track His Diabetes Onset |
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March 15, 2012 • Stanford School of Medicine |
New Technique Enables Researchers to Mine Drug Reports to Discover Side Effects and Interactions |
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March 14, 2012 • Stanford University School of Medicine |
Genetic Difference Connects Childhood Cancer Drugs to Heart Problems Later in Life |
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December 16, 2011 • University at Buffalo |
Pharmacogenomics Study Links Rare Inherited Variants to Drug Response |
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December 6, 2011 • Genome Research |
Inherited Factors Affect the Response to Chemotherapy Drugs to Differing Degrees |
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October 27, 2011 • UNC Cancer Center |
Family of Four Receives Whole Genome Analysis of Their Health Risks |
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September 16, 2011 • U.S. News & World Report |
Find New Uses For Existing Drugs By Mining Gene-Activity Data Banks |
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August 17, 2011 • Stanford University |
Interaction Between Two Common Drugs Can Raise Blood Glucose Levels |
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May 25, 2011 • Stanford University |
Genetic Variation Tied to Risk of Relapse in Childhood Leukemia |
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February 6, 2011 • St. Jude Children's Research Hospital |
NIH Study Links Gene Variants to Breast-Cancer Drug Side Effect |
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September 28, 2010 • National Institute of General Medical Sciences |
$12 Million NIH Grant to Develop Personalized Approach to Smoking Cessation |
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September 21, 2010 • University of Pennsylvania Almanac |
NIH Expands Key Pharmacogenomics Resource |
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September 7, 2010 • National Institute of General Medical Sciences |
NIH Expands Network Focused on How Genes Affect Drug Responses |
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September 7, 2010 • National Institute of General Medical Sciences |
Global Alliance for Pharmacogenomics Grows to 18 Projects |
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May 21, 2010 • National Institute of General Medical Sciences |
Patient’s Whole Genome Reveals Risk of Diseases and Adverse Drug Responses |
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April 29, 2010 • National Institute of General Medical Sciences |
Global Alliance for Pharmacogenomics Adds Five New Projects |
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December 16, 2009 • National Institute of General Medical SciencesThe new projects, which focus on drugs for depression, HIV/AIDS, cardiovascular disease and cancer, bring to 15 the total number of projects in the Global Alliance for Pharmacogenomics. |
Gene Variant Linked to Risk of Stroke and Heart Attack for Those on Plavix |
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August 25, 2009 • National Institute of General Medical SciencesA new study reports that a gene variant carried by about a third of the population plays a major role in this group’s response to an anti-clotting medicine, clopidogrel (Plavix). People with the variant produce a defective version of the CYP2C19 enzyme and are less able to activate the drug, placing them at increased risk for dangerous events like strokes and heart attacks. |
Gene Variant Linked to Effectiveness of Plavix |
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August 25, 2009 • University of Maryland Medical CenterNIGMS-supported researchers have identified a common gene variant carried by as many as a third of the population that plays a major role in determining why some people do not respond to an anti-clotting medication, Plavix. |
Inherited Factors Linked to Risk of Childhood Cancer |
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August 16, 2009 • St. Jude Children’s Research HospitalNIGMS-supported scientists have identified inherited variations in two genes that account for 37 percent of childhood acute lymphoblastic leukemia, including a gene that may help predict drug response. |
Genes in High-Risk Childhood Leukemias |
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May 19, 2009 • St. Jude Children's Research HospitalNIGMS-funded researchers have discovered a new class of mutations linked to cases of childhood leukemia with a high risk of relapse and death. |
Could Genetics Improve Warfarin Dosing? |
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February 18, 2009 • National Institute of General Medical SciencesA world wide team of researchers used computer modeling to address one of the trickiest drugs to prescribe—the blood-thinner warfarin. To test the gene-based strategy in patients, NIH is launching a large-scale clinical trial. |
Many Genetic Variations Linked to Leukemia Treatment |
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January 27, 2009 • St. Jude Children's Research HospitalScientists in the NIGMS-funded Pharmacogenetics Research Network have linked scores of genetic variations with how children respond to leukemia drugs. |
Global Alliance for Pharmacogenomics Expands |
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November 10, 2008 • National Institute of General Medical SciencesU.S. and Japanese scientists expand their pharmacogenomics collaboration with five new projects. |
Launching a Global Alliance for Pharmacogenomics |
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April 14, 2008 • National Institute of General Medical SciencesU.S. and Japanese scientists partner to study genetic factors that influence the safety and effectiveness of medicines. |
Gene Expression Differences Affect Response to Drugs, Infections |
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February 28, 2008 • University of Chicago Medical CenterResearchers in the NIGMS-funded Pharmacogenetics Research Network have found that differences in gene expression levels between population groups can affect how they respond to drugs or fight off specific infections. |
PGRN Researchers Question Need for Genetic Tests in All Cases |
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August 28, 2007 • University of North Carolina at Chapel HillPeople taking low doses of the cancer drug irinotecan need not undergo genetic testing first, say NIGMS-funded researchers. |
Pharmacogenetics Guides Dosing of Common Blood Thinner |
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August 16, 2007 • Food and Drug AdministrationWork by investigators affiliated with the NIH Pharmacogenetics Research Network has led to changes in the prescribing information of a widely used blood-thinning drug, warfarin (Coumadin). |
Variations in Genes Linked to Toxicity of Leukemia Therapy |
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May 11, 2007 • St. Jude Children's Research HospitalAn NIGMS-funded study has discovered variations in certain genes that make some children with leukemia susceptible to toxic side effects from common chemotherapy drugs. |
Hints for Better Care of Leukemia Survivors |
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March 20, 2007 • St. Jude Children's Research HospitalThe longest follow-up study ever done on children with acute lymphoblastic leukemia, supported in part by NIGMS, identifies risks for survivors later in life. |
Large Study Links Mutations to Leukemia |
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March 7, 2007 • St. Jude Children's Research HospitalNIGMS-funded researchers scanned 350,000 locations across the genome of 242 pediatric patients with acute lymphoblastic leukemia to identify new mutations that contribute to this common childhood cancer. |
Computer Tool Helps Spot Risky Mutations |
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February 15, 2007 • Johns Hopkins UniversityNIGMS-funded researchers have created a computer tool to help predict which genetic mutations might affect a person's risk for cancer. |
Current Cancer Therapy May Soon be Obsolete |
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April 18, 2006 • Washington UniversityFindings made by NIGMS-supported investigators suggest that traditional cancer treatments, which base drug regimens on a tumor's anatomical location, should eventually be replaced with therapies based on a tumor's pharmacologic profile. |
NIH Awards Grant to Study Pharmacogenetics of Nicotine Addiction and Treatment |
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January 25, 2006 • SRI InternationalSRI International and the University of California, San Francisco, have been awarded $10 million to study the genetic basis for variation in response to medications for tobacco dependence. The new program will be part of the Pharmacogenetics Research Network (PGRN). |
Genes' Influence on Drugs May Affect Health-Care Quality |
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January 4, 2006 • Washington UniversityChances are good that a medication you take is one of several drugs that can be affected by genetic factors, according to a team of NIGMS-supported researchers. |
Pharmacogenetics Test Licensed to Mayo Clinic |
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December 21, 2005 • University of ChicagoResearchers supported through the NIH Pharmacogenetics Research Network have licensed a genetic test for patients with colorectal cancer to the Mayo Clinic. The agreement will make the test available to patients nationwide starting this month. |
Tamoxifen Benefit Tied to Inherited Gene |
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December 16, 2005 • Mayo ClinicOne of the most commonly administered drugs for breast cancer, tamoxifen, may not be as effective for women who inherit a common genetic change, according to an NIGMS-supported study. |
NIH Renews Network Focused On How Genes Influence Drug Responses |
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September 28, 2005 • National Institute of General Medical Sciences |
NIGMS Awards $10 Million for Pharmacogenetics Research |
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August 29, 2005 • Washington University in St. LouisNIGMS has awarded $10 million to researchers investigating how well anti-cancer therapies work in different patients. The funds will further work begun in 2001 as part of the NIGMS-supported Pharmacogenetics Research Network, a nationwide collaboration of scientists. |
UF Researcher Gets $11 Million To Study Genes, Blood Pressure Drugs |
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August 18, 2005 • University of Florida |
$15 Million Grant Extends Study of How Genes Affect Cancer Chemotherapy |
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July 13, 2005 • University of Chicago Medical Center |
Genetic Variation Alters Response to Common Anti-Clotting Drug |
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June 2, 2005 • National Institute of General Medical SciencesVariations in a gene involved in blood clotting may explain why certain people require a lower or higher dose to get the full benefits of the anticoagulant drug warfarin, say NIGMS-funded researchers at the University of Washington in Seattle and Washington University in St. Louis.
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New Insights Into Why Medicines Work Differently Among People |
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April 2, 2002 • National Institute of General Medical Sciences |
Pharmacogenetics Research Network Chooses Journal to Publish PharmGKB Data |
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November 9, 2001 • National Institute of General Medical Sciences |
Simple Breath Test Predicts Gene-Linked Drug Response |
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October 26, 2001 • National Institute of General Medical Sciences |
NIH Pharmacogenetics Research Network Announces New Members |
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September 4, 2001 • National Institute of General Medical Sciences |
Pharmacogenetics Research Network Seeks Journal Partnership |
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June 1, 2001 • National Institute of General Medical Sciences |
NIH Hosts First Annual Meeting of the Pharmacogenetics Research Network |
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April 10, 2001 • National Institute of General Medical Sciences |
NIH To Study How Genes Affect Response to Medicines |
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August 8, 2000 • National Institute of General Medical Sciences |
First Awards Made in NIH Effort to Understand How Genes Affect People's Responses to Medicines |
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April 4, 2000 • National Institute of General Medical Sciences |