A Role for Small Antibody Fragments to Bind and Neutralize HIV
Env an attractive target for designing therapeutic inhibitory antibodies. Learn more about how small antibody fragments can bind and neutralize HIV…
Posted: 02/2013
Sunitinib Proves Beneficial in Metastatic Kidney Cancer
Many researchers and clinicians consider targeted therapies, such as tyrosine kinase inhibitors and antibody-based drugs, to be a great advance in the treatment of patients with cancer.…Learn how sunitinib is beneficial for treating kidney cancer
Posted: 2/2013
CD22: A Promising Target for Acute Lymphoblastic Leukemia Treatment
There are about 4,000 new cases of acute lymphoblastic leukemia (ALL) in the United States each year. Learn more about acute lymphoblastic leukemia treatment…
Posted: 2/2013
Newly-Identified Fragile Sites Push Stressed Cells toward Cancer
Understanding how the changes in genomes of cancer cell arise can give researchers new insights into the process of cancer development. Learn more about the chromosomal alterations of cancer cells…
Posted: 01/2013
Intermittent IL-7 Signaling Essential for T cell Homeostasis
IL-7 signaling must be intermittent, not continuous, during CD8(+) T cell homeostasis to promote cell survival instead of cell death. Read more about T cell Homeostasis...
Posted: 01/2013
Staying Alive: Cancer Cells Expressing Mutant KRas Depend on ERH for Survival
The small G-protein KRas acts like a molecular switch, turning on and off pro-growth signaling pathways within cells when appropriate. Learn more about KRas…
Posted: 12/2012
RNAi Functions in Adaptive Reprogramming of the Genome
The regulation of transcribing DNA into RNA, including the production, processing, and degradation of RNA transcripts, affects the expression and the regulation of the genome in ways that are just beginning to be unraveled. Learn more about transcribing the genome...
Posted: 12/2012
Putting on the Brakes: Blocking the Growth of Metastases
Most of the suffering and death caused by cancer is due, not to the primary tumor, but to the ability of cancer cells to spread throughout the body and to form metastases in other organs. Learn more about metastases…
Posted: 11/2012
Finding a Chink in the Armor by Investigating the Structure of HIV
The Human Immunodeficiency Virus (HIV) infects and eventually kills CD4-expressing T cells, which are essential for the immune system to function appropriately. Learn more about the structure of HIV...
Posted: 8/2012
What a Shock: No Apoptosis without Heat Shock Protein 90α
Apoptosis, also known as programmed cell death, consists of a series of reactions designed to systematically chop up a cell and its contents. Learn more about apoptosis…
Posted: 7/2012
New Web-Based Tools Make Systems Pharmacology More Accessible Using Data from
the NCI-60
High-throughput biological techniques, like microarrays and drug screens, generate an enormous amount of data that may be critically important for cancer researchers and clinicians. Learn more about data from the NCI-60…
Posted:7/2012
CTCF, a Novel Regulator of Alternative Splicing
Alternative splicing, or the inclusion of different patterns of exons from the same gene, plays an important role in expanding the coding possibilities of a limited genome. Learn more about CTCF…
Posted: 7/2012
Smurf2 Regulates DNA
Repair and Packaging to Prevent Tumors
The blueprint for all of a cell’s functions is written in the genetic code of DNA sequences as well as in the landscape of DNA and histone modifications. Learn more about how Smurf2 regulates DNA repair and packaging to prevent tumors…
Posted: 6/2012
Brachyury Protein: A Potential Target in Lung Cancer Therapy
Previous research has shown that Brachyury protein plays a role in initiating the processes that lead to the growth and spread of cancer. Learn more about the Brachyury protein...
Posted: 6/2012
