News

Toxicologic Pathology of the Digestive Tract and Pancreas

32nd Symposium of the Society of Toxicologic Pathology

Comparative Oncology: Man's Best Friend in More Ways than One

 

NIH plans to relocate its chimpanzees from New Iberia to the Federal Sanctuary System

 

NIH proposes critical initiatives to sustain future of U.S. biomedical research

Actions would aim to strengthen the biomedical research workforce and manage deluge of data

Meeting Announcement: Frontiers of Biomedical Imaging Science IV

July 15 - 18, 2013 Vanderbilt University Institute of Imaging Science Student Life Center Nashville, TN

Rules Would Retire Most Research Chimps

by Nell Greenfieldboyce (broadcasted on NPR on January 23, 2013)

NCI Mouse Repository Status Report

presented at the MMHCC Steering Committee Meeting in January 2013

NCI Mouse Repository Colony Begins Distribution

 

Retirement of Rat Strains

 

caMOD 2.7.2 released

 

In Mice, Combining Cancer Vaccine and Low-Dose Anti-Angiogenesis Drug Shows Promise against Breast Cancer

 

Bioportal 3.11 released

 

caBIO Release 4.3.2

 

Release of caMOD 2.7.1

 

NIH–sponsored workshop calls for more detailed reporting in animal studies

Improved study design and data sharing are expected to speed therapy development

NIH-funded researchers restore sense of smell in mice using genetic technique

Study could lead way to first therapeutic treatment for people born with anosmia

Dark matter DNA active in brain during day — night cycle

NIH study of rats shows DNA regions thought inactive highly involved in body’s clock

Rembrandt 1.5.6 release

REMBRANDT is a joint initiative of the NCI and NINDS hosts diverse types of molecular research and clinical trials data related to brain cancers, including gliomas, along with a wide variety of web-based analysis tools that readily facilitate the understanding of critical correlations among the different data types.

Making you smile

 

Keeping up with MMRRC News

 

What’s new in caMOD – July 2012

The following models have been approved for public display.

caIntegrator 1.4 is released

 

Mapping the Molecular Changes in Colorectal Cancer

 

Cancer Molecular Analysis Portal (CMA) has been retired

 

caArray 2.5.0 is released

 

Tumors May Resist Cancer Drugs with Help from Neighboring Cells

 

Launch of the National Cancer Informatics Program (NCIP)

 

Five more pharmaceutical companies join NIH initiative to speed therapeutic discovery

Nearly 60 compounds from industry collaborators now publicly available

caNanoLab 1.5.3 released

 

LS DAM 2.2.3 released

Version 2.2.3 of the Life Sciences Domain Analysis Model (LS DAM) has been released. The LS DAM is a shared view of the semantics for life sciences which includes hypothesis driven basic and pre-clinical research as well as discovery sciences.

Registration for the 11th Transgenic Technology (TT2013) meeting is now open

The TT2013 meeting will take place in Guangzhou, China on February 25-27, 2013.

National Institute on Drug Abuse (NIDA) Seeks Applications Using the JAX Diversity Outcross (DO) Mice

NOT-DA-12-013

What’s new in caMOD – April 2012

The following model has been approved for public display.

NCI Mouse Repository Strain Goes Public – iDCT-GFP

The NCI Mouse Repository distributes mouse cancer models and associated strains to all members of the scientific community.

Visiting Scholars Program at Frederick National Laboratory for Cancer Research

Submit an Expression of Interest by May 11, 2012

New Mice on the Block

After 10 years in development, a novel mouse population proves its mettle in complex trait research. By Megan Scudellari

Model Organisms to Human Biology – Cancer Genetics Meeting

 

caBIG® Community Code Resource Directory

 

Mouse Collaborative Cross Articles in Genetics Society of America Journals

 

NPR reports about the new guidelines for rodent cages

New advice on housing lab rodents has left research centers confused and worried about the costs.

Life Sciences Domain Analysis Model (LS DAM) v2.2.2 available

 

News from KOMP – December 2011

The KOMP Repository is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice. Nearly 8500 genes are targeted for deletion, most in a conditional-ready format, by mutagenesis teams at "CSD" (Childrens Hospital of Oakland Research Institute, The Sanger Institute, and UC Davis) and at Regeneron, Inc. You can obtain targeting vectors, ES cells, mice, and germplasm, as well as microinjection, genotyping, cryopreservation, breeding, and other services quickly and at reasonable cost to help you with your research project.

NCI Mouse Repository Strain Goes Public – Langerin-Cre

The NCI Mouse Repository distributes mouse cancer models and associated strains to all members of the scientific community.

NCI Mouse Repository Strain Goes Public - ED-L2/Cre

The NCI Mouse Repository distributes mouse cancer models and associated strains to all members of the scientific community.

NIH eases tech transfer with online material transfer agreements

 

Study Raises Concerns about Using Cancer Cell Lines to Test Drug Resistance

 

Cyclin D3 compensates for the loss of Cyclin D1 during ErbB2-induced mammary tumor initiation and progression.

Cyclin D1 regulates cell proliferation and is a candidate molecular target for breast cancer therapy. This study addresses whether Cyclin D1 is indispensable for ErbB2-associated mammary tumor initiation and progression using a breast cancer model in which this cell-cycle regulator can be genetically ablated prior to or after neoplastic transformation.

Implementation of the Guide for the Care and Use of Laboratory Animals: Eighth Edition

NIH announces that it has determined to adopt the 8th Edition of the Guide for the Care and Use of Laboratory Animals (Guide) effective January 1, 2012. (NOT-OD-12-020)

News from KOMP - November 2011

The KOMP Repository is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice. Nearly 8500 genes are targeted for deletion, most in a conditional-ready format, by mutagenesis teams at "CSD" (Childrens Hospital of Oakland Research Institute, The Sanger Institute, and UC Davis) and at Regeneron, Inc. You can obtain targeting vectors, ES cells, mice, and germplasm, as well as microinjection, genotyping, cryopreservation, breeding, and other services quickly and at reasonable cost to help you with your research project.

NIH researchers design a light therapy that targets and destroys cancer cells in mice

Researchers have designed a light-based therapy that allows the selective destruction of tumor cells in mice without harming surrounding normal tissue.

News from KOMP - October 2011

The KOMP Repository is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice. Nearly 8500 genes are targeted for deletion, most in a conditional-ready format, by mutagenesis teams at "CSD" (Childrens Hospital of Oakland Research Institute, The Sanger Institute, and UC Davis) and at Regeneron, Inc. You can obtain targeting vectors, ES cells, mice, and germplasm, as well as microinjection, genotyping, cryopreservation, breeding, and other services quickly and at reasonable cost to help you with your research project.

News from KOMP - September 2011

The KOMP Repository is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice. Nearly 8500 genes are targeted for deletion, most in a conditional-ready format, by mutagenesis teams at "CSD" (Childrens Hospital of Oakland Research Institute, The Sanger Institute, and UC Davis) and at Regeneron, Inc. You can obtain targeting vectors, ES cells, mice, and germplasm, as well as microinjection, genotyping, cryopreservation, breeding, and other services quickly and at reasonable cost to help you with your research project.

International Mouse Phenotyping Consortium (IMPC)

The International Mouse Phenotyping Consortium (IMPC) comprises a group of major mouse genetics research institutions along with national funding organisations formed to address the challenge of developing an encyclopedia of mammalian gene function.

caB2B hosting update

cancer Bench-to-Beside - caB2B - is an open-source query tool that permits translational research scientists to search and combine data from virtually any caGrid data service. The caB2B suite is composed of three core components: the Web application, the Client Application and the Administrative Module. The caB2B Web Application provides query templates that allow easy search and retrieval of microarray data (from caArray), imaging data (from the National Biomedical Imaging Archive (NBIA)), specimen data (from caTissue) and nanoparticle data (from caNanoLab) across the grid. Searches can be performed on selected locations using either form-based or keyword searches and data can be exported in the CSV format.

News from KOMP – August 2011

The KOMP Repository is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice. Nearly 8500 genes are targeted for deletion, most in a conditional-ready format, by mutagenesis teams at "CSD" (Childrens Hospital of Oakland Research Institute, The Sanger Institute, and UC Davis) and at Regeneron, Inc. You can obtain targeting vectors, ES cells, mice, and germplasm, as well as microinjection, genotyping, cryopreservation, breeding, and other services quickly and at reasonable cost to help you with your research project.

caBIG® Spotlight - Solving Research Problems: Analyze Mouse Embryonic Stem Cell Transcriptional Profiles

Read a case study to learn more about how Dr. Bradley Merrill of the University of Illinois at Chicago and his lab were able to perform their first gene expression array experiment comparing a mutant mouse embryonic stem cell line to a non-mutant control line using GenePattern, an application supported by the Molecular Analysis Tools Knowledge Center which provides bioinformatics tools for gene expression, proteomic and SNP analysis.

caBIG® Spotlight - Inventory of Digital Information Resources for Researchers

A living inventory has been created to provide the scientific, biomedical informatics and health IT communities with access to data from clinical research, biospecimens, in vivo images, molecular signatures, and population studies of multiple cancer types, as well as nanotechnology applications and reference information.

Online Conference - Mining for Cancer Biomarkers: from Genes to Tissues

13 December 2011 to 15 December 2011 Abstract Deadline: 4 November 2011 Online Web Event

Online Conference - Mouse Models of Cancer

16 Novemberr 2011 to 18 November 2011 Abstract Deadline: 3 October 2011 Online Web Event

A resource of vectors and ES cells for targeted deletion of microRNAs in mice.

Prosser HM, Koike-Yusa H, Cooper JD, Law FC, Bradley A.

NCI Mouse Repository Strain Goes Public - Rosa LSL SBase/TG12740

The NCI Mouse Repository distributes mouse cancer models and associated strains to all members of the scientific community.

NCI Mouse Repository Strain Goes Public - Rosa LSL SBase/TG12775

The NCI Mouse Repository distributes mouse cancer models and associated strains to all members of the scientific community.

NCI Mouse Repository Strain Goes Public - Nkx3.1-Cre

The NCI Mouse Repository distributes mouse cancer models and associated strains to all members of the scientific community

caIntegrator 1.3 release

The caIntegrator team is pleased to announce the release of caIntegrator version 1.3 (formerly caIntegrator2).

News from KOMP – July 2011

The KOMP Repository is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice. Nearly 8500 genes are targeted for deletion, most in a conditional-ready format, by mutagenesis teams at "CSD" (Childrens Hospital of Oakland Research Institute, The Sanger Institute, and UC Davis) and at Regeneron, Inc. You can obtain targeting vectors, ES cells, mice, and germplasm, as well as microinjection, genotyping, cryopreservation, breeding, and other services quickly and at reasonable cost to help you with your research project.

News from KOMP – May 2011

The KOMP Repository is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice. Nearly 8500 genes are targeted for deletion, most in a conditional-ready format, by mutagenesis teams at "CSD" (Childrens Hospital of Oakland Research Institute, The Sanger Institute, and UC Davis) and at Regeneron, Inc. You can obtain targeting vectors, ES cells, mice, and germplasm, as well as microinjection, genotyping, cryopreservation, breeding, and other services quickly and at reasonable cost to help you with your research project

News from KOMP – April 2011

The KOMP Repository is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice. Nearly 8500 genes are targeted for deletion, most in a conditional-ready format, by mutagenesis teams at "CSD" (Childrens Hospital of Oakland Research Institute, The Sanger Institute, and UC Davis) and at Regeneron, Inc. You can obtain targeting vectors, ES cells, mice, and germplasm, as well as microinjection, genotyping, cryopreservation, breeding, and other services quickly and at reasonable cost to help you with your research project.

What's new in caMOD - April 2011

The following models have been approved for public display in April 2011.

caTissue Suite 1.2 released

caTissue Suite 1.2 is an open-source, web and programmatically accessible tool for managing biospecimens collected in support of basic and clinical research. Building on the capabilities of previous releases the application helps users manage biospecimen inventory, annotation and sample tracking. It also supports clinical and pathology report annotation and provides query capabilities for researchers to identify and find biospecimens for their research projects. In addition, it features "Dynamic Extensions", allowing Biorepositories to extend the caTissue data model and develop annotations customized for their institution.

NCI Mouse Repository Strain Goes Public - K5/tTA

The NCI Mouse Repository distributes mouse cancer models and associated strains to all members of the scientific community.

NCI Mouse Repository Strain Goes Public - CAG-LSL-EGFR-WT

The NCI Mouse Repository distributes mouse cancer models and associated strains to all members of the scientific community.

NCI Mouse Repository Strain Goes Public - CAG-LSL-EGFRvIII

The NCI Mouse Repository distributes mouse cancer models and associated strains to all members of the scientific community.

What's new in caMOD - March 2011

The following models have been approved for public display in March 2011.

NCI Mouse Repository Strain Goes Public – Nkx3.1-CreERT2

The NCI Mouse Repository distributes mouse cancer models and associated strains to all members of the scientific community.

NCI Mouse Repository Strain Goes Public - Arf floxed

The NCI Mouse Repository distributes mouse cancer models and associated strains to all members of the scientific community.

NCI Mouse Repository Strain Goes Public - Rosa LSL SBase/TG6113

The NCI Mouse Repository distributes mouse cancer models and associated strains to all members of the scientific community.

What's new in caMOD - February 2011

The following models have been approved for public display in February 2011.

The Cancer Genome Atlas (TCGA) Launches a Redesigned and Expanded Web Site

 

News from KOMP - February 2011

The KOMP Repository is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice. Nearly 8500 genes are targeted for deletion, most in a conditional-ready format, by mutagenesis teams at "CSD" (Childrens Hospital of Oakland Research Institute, The Sanger Institute, and UC Davis) and at Regeneron, Inc. You can obtain targeting vectors, ES cells, mice, and germplasm, as well as microinjection, genotyping, cryopreservation, breeding, and other services quickly and at reasonable cost to help you with your research project.

Pathway Interaction Database (PID)

The National Cancer Institute (NCI) in collaboration with Nature Publishing Group has established the Pathway Interaction Database (PID) in order to provide a highly structured, curated collection of information about known biomolecular interactions and key cellular processes assembled into signaling pathways.

NCI Mouse Repository Strain Goes Public - Myf6-ires-cre knock-in

The NCI Mouse Repository distributes mouse cancer models and associated strains to all members of the scientific community.

NCI Mouse Repository Strain Goes Public - Rosa LSL SBase/TG6070

The NCI Mouse Repository distributes mouse cancer models and associated strains to all members of the scientific community.

caMOD 2.7 released

 

NCI Mouse Repository Strain Goes Public - Pax3:Fkhr conditional knock-in

The NCI Mouse Repository distributes mouse cancer models and associated strains to all members of the scientific community.

NCI Mouse Repository Status Report

 

Mouse Studies Point to Prognostic Test for Prostate Cancer

 

What's new in caMOD - January 2011

The following models have been approved for public display in January 2011.

News from KOMP - January 2011

The KOMP Repository is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice. Nearly 8500 genes are targeted for deletion, most in a conditional-ready format, by mutagenesis teams at "CSD" (Childrens Hospital of Oakland Research Institute, The Sanger Institute, and UC Davis) and at Regeneron, Inc. You can obtain targeting vectors, ES cells, mice, and germplasm, as well as microinjection, genotyping, cryopreservation, breeding, and other services quickly and at reasonable cost to help you with your research project.

Eau de Choice

 

News from KOMP - December 2010

The KOMP Repository is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice. Nearly 8500 genes are targeted for deletion, most in a conditional-ready format, by mutagenesis teams at "CSD" (Childrens Hospital of Oakland Research Institute, The Sanger Institute, and UC Davis) and at Regeneron, Inc. You can obtain targeting vectors, ES cells, mice, and germplasm, as well as microinjection, genotyping, cryopreservation, breeding, and other services quickly and at reasonable cost to help you with your research project.

What's new in caMOD - December 2010

The following models have been approved for public display in December 2010.

caNanoLab 1.5.2 released

caNanoLab is a data sharing portal designed to facilitate information sharing in the biomedical nanotechnology research community to expedite and validate the use of nanotechnology in biomedicine. caNanoLab provides support for the annotation of nanomaterials with characterizations resulting from physico-chemical and in vitro assays and the sharing of these characterizations and associated nanotechnology protocols in a secure fashion.

What's new in caMOD - November 2010

The following models have been approved for public display in November 2010.

News from KOMP - October 2010

The KOMP Repository is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice. Nearly 8500 genes are targeted for deletion, most in a conditional-ready format, by mutagenesis teams at "CSD" (Childrens Hospital of Oakland Research Institute, The Sanger Institute, and UC Davis) and at Regeneron, Inc. You can obtain targeting vectors, ES cells, mice, and germplasm, as well as microinjection, genotyping, cryopreservation, breeding, and other services quickly and at reasonable cost to help you with your research project.

What's new in caMOD - October 2010

The following models have been approved for public display in October 2010.

What's new in caMOD - September 2010

The following models have recently been approved for public display. Visit http://cancermodels.nci.nih.gov to learn more about these new models.

Better housing fights cancer in mice

Enriching animals' environments does much more than improve their psyches -- it may fight deadly disease, according to a study published online today (July 8) in Cell.

News from KOMP - September 2010

The KOMP Repository is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice. Nearly 8500 genes are targeted for deletion, most in a conditional-ready format, by mutagenesis teams at "CSD" (Childrens Hospital of Oakland Research Institute, The Sanger Institute, and UC Davis) and at Regeneron, Inc. You can obtain targeting vectors, ES cells, mice, and germplasm, as well as microinjection, genotyping, cryopreservation, breeding, and other services quickly and at reasonable cost to help you with your research project.

News from KOMP - August 2010

The KOMP Repository is the official archive and distribution center for the Knockout Mouse Project (KOMP), a major 5-year trans-NIH initiative designed to generate null alleles in C57BL/6 embryonic stem (ES) cells for most genes not already available as knockout mice. Nearly 8500 genes are targeted for deletion, most in a conditional-ready format, by mutagenesis teams at "CSD" (Childrens Hospital of Oakland Research Institute, The Sanger Institute, and UC Davis) and at Regeneron, Inc. You can obtain targeting vectors, ES cells, mice, and germplasm, as well as microinjection, genotyping, cryopreservation, breeding, and other services quickly and at reasonable cost to help you with your research project.

Textpresso for Mouse

Textpresso is an information extracting and processing package for biological literature

Quantitative Evaluation of Tissue Preservation

Modern diagnostic pathology requires that both morphology and molecular integrity are preserved throughout processing and handling of the tissue. The major challenge for molecular analysis of breast cancer samples is to preserve the molecular integrity of the specimen while insuring the structural integrity needed for diagnostic pathology.