Thyroid Cancer
Clinical and Genetic Studies in Familial Non-medullary Thyroid Cancer
NCI-10-C-0102, NCT01109420
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Investigator(s): |
Electron Kebebew, M.D., F.A.C.S. Principal Investigator Phone: 301-496-5049 Fax: 301-402-1788 kebebewe@mail.nih.gov
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Erinn M. Hopkins Clinical Research Coordinator Phone: 301-496-6457 erinn.hopkins@nih.gov
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Krisana Gesuwan, C.R.N.P. Research Nurse Specialist Phone: 301-402-4395 Fax: 301-451-6933 gesuwank2@mail.nih.gov
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Jean Ward, R.N., B.S.N., O.C.N. Research Nurse Phone: 301-827-4988 Fax: 301-480-2481 wardjl@mail.nih.gov
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Key Eligibility Criteria:
- An individual with two first-degree relatives who have or have had non-medullary thyroid cancer or a documented diagnosis of non-medullary thyroid cancer and one living relative with documented non-medullary thyroid cancer (Note: because this is a familial study, subjects do not need to present with the disease) OR any member of an affected family (Note: for this study, an affected family is defined as a family having two or more first-degree relatives with a documented diagnosis of familial non-medullary thyroid cancer)
- > 7 years of age**
- Adults must be able to understand and sign the informed consent document and complete the family history questionnaire
* Patients do not need to present with the disease
** At least one parent must provide consent for pediatric patients; patients will be re- consented once they reach the age of majority
Study Outline:
- Detailed history and physical examination, including demographic information, family history, environmental risk assessment, and pathology reports from all affected family members
- Blood and urine samples
- Imaging studies
- Patients who have suspicious lesions and do not have a definitive diagnosis of thyroid cancer will undergo a thyroid biopsy
- Any patient found to have evidence of non-medullary thyroid cancer that has not been treated surgically or with radioiodine ablation may receive treatment at the National Cancer Institute based on standard treatment guidelines and existing protocols or may be referred to an outside institution
- Reevaluation visit every year
Additional Information:
- This trial will be conducted at the NIH Clinical Center in Bethesda, MD. It is open to patients who meet the eligibility requirements, regardless of where they live in the United States.
- There is no charge for medical care received at NIH Clinical Center.
- FAQs about this study - provides information for patients about the trial such as frequency and duration of visits, costs, how to enroll, and study outline.
- PDQ (Physicians Data Query) - provides additional details about this study for health care providers.
Reviewed: 12/14/12
Updated: 11/12/12