Blood and Marrow Transplant Clinical Trials Network (BMT CTN) Treatment for Acute Graft-Versus-Host Disease (BMT CTN 0302)
Website: https://web.emmes.com/study/bmt2
Parent Study Contact:
Alan Howard,
ahoward@nmdp.org
Study Type:
Clinical Trial
Prepared on September 14, 2010
Consent: Proprietary Consent
Commercial Use Restrictions:
No
Collection Type: Proprietary Study
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Objectives
This study was a randomized Phase II, four arm treatment trial. Patients with newly diagnosed acute GVHD received corticosteroids plus one of four agents: etanercept, mycophenolate mofetil (MMF), Denileukin Diftitox (ONTAK) or pentostatin. Each agent was assessed for safety and efficacy compared to historical complete response rates to acute GVHD therapy with corticosteroids alone.