EGRP-Supported Health Disparities Research
Overview
The National Cancer Institute (NCI) has targeted the reduction of cancer-related health disparities as an important challenge. Health disparities are differences in the incidence, prevalence, mortality, and burden of cancer and related adverse health conditions that exist among specific population groups in the United States. These population groups may be characterized by gender, age, ethnicity, education, income, social class, disability, geographic location, or sexual orientation. The goal is to understand the causes of health disparities in cancer and develop effective interventions to reduce or eliminate them.
Funding Opportunities
There are not currently any specific EGRP-sponsored or co-sponsored Requests for Applications (RFAs) or Program Announcements (PAs) for health disparities research; however, related NIH Funding Opportunity Announcements (FOAs) are available.
- Cancer Control and Population Sciences Funding Opportunities for Health Disparities
- NCI Center to Reduce Cancer Health Disparities
- National Institute on Minority Health and Health Disparities
EGRP joins with other NCI Divisions, Offices, and Centers and other Institutes and Centers at the National Institutes of Health (NIH) to fund grant applications submitted in response to FOAs. View the full list of EGRP FOAs.
EGRP also encourages investigator-initiated grant applications on health disparities topics.
Funded Projects
The Epidemiology and Genomics Research Program (EGRP) supports a variety of research addressing health disparities. To learn more about EGRP's health disparities research portfolio, view a list of EGRP's active health disparities grants.
Cohort StudiesOngoing, large, investigator-initiated cohort studies have and will continue to be critical to understanding the determinants of cancer incidence and mortality in underserved populations. These studies involve collection of extensive health information and biological specimens from thousands to tens-of-thousands of persons from different population groups who are then followed over time to determine cancer occurrence or death from cancer.
Examples of cohort studies funded at least in part by EGRP which are contributing to the understanding of cancer-related disparities include:
- Black Women's Health Study
- Multiethnic/Minority Cohort Study of Diet and Cancer (MEC)
- Southern Community Cohort Study
Case-Control Studies
Case-control studies are another commonly used approach in epidemiologic research. In case-control studies persons with cancer and persons without cancer are compared in terms of genetic, lifestyle and other factors, such as race and ethnicity, age, gender, socioeconomic status, and geographic location. Comparisons within case-control studies, such as by ethnic group, can provide key insights into differences in cancer risk. EGRP supports many case-control studies. One project, funded by the 2009 American Recovery and Reinvestment Act (ARRA), is investigating prostate cancer incidence and mortality among African-American men, a population with particularly high rates. Learn more.
Cancer Epidemiology Consortia
EGRP also supports cancer epidemiology consortia to complement individual investigator-initiated studies. Data and resource sharing by consortia members promotes the rapid replication of research results from individual studies.
Examples of EGRP-supported consortia studying specific populations include:
Research Resources
Two large research resources sponsored by EGRP which recruit participants and collect data (which can be requested by investigators) from a variety of population groups are:
EGRP and the Division of Cancer Control and Population Sciences (DCCPS) supports regional studies or tools which include research that compares populations with respect to the distribution of risk factors and cancer risk.
Contacts
For general questions about NCI's interest in health disparities, EGRP contacts include:
- Chemical and physical agents, social and behavioral environment -
Gary L. Ellison, Ph.D., M.P.H. - Tumor biology and cancer epidemiology in Caribbean and African populations -
Damali N. Martin, Ph.D., M.P.H. - Dietary intake, carcinogenic chemicals in foods, lifestyle factors, and molecular mechanisms that underlie cancer risk -
L. Joseph Su, Ph.D., M.P.H. - Biomarkers, epigenetics, metabolomics, proteomics, and risk assessment -
Mukesh Verma, Ph.D. - Biological determinants of health disparities associated with cancer and genome-wide association studies -
Krista A. Zanetti, Ph.D., M.P.H., R.D.