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This file provides an easy to use, fast compiled C program that runs in a DOS window for computing optimal and minimax two-stage designs for phase II clinical trials. The program is based on the paper by R. Simon: "Optimal two stage designs for phase II clinical trials", Controlled Clinical Trials 10:1-10, 1989. To use the program, open a DOS window using the command prompt menu item in your start menu. CD to the directory into which you have put the file, and execute it.

Please send comments and suggestions to brb@linus.nci.nih.gov