A portion of a file containing LC/MS data from analysis of hippocampal PSDs from lithium treated rats. Each peak contains tandem MS/MS information characterizing component peptides from tryptic digestion of proteins. |
The Laboratory of Neurotoxicology conducts research to determine the biochemical events that cause neuronal injury and degeneration accompanying genetic disease, inflammation, trauma, and exposure to neurotoxic substances.
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The Analytical
Biochemistry Section emphasizes research that utilizes qualitative and quantitative molecular structure analyses to determine cellular responses to diseases and neurotoxins. Methods for the mass spectrometric analysis of protein structures is being applied in projects on the structural biology of sub-cellular organelles. Software to aid in these studies is also being developed.
The Molecular
Structure Unit focuses on the identification and characterization of bioactive components of biological fluids and tissues. Other projects of interest are drawn from proteins that are of medical interest due to their ability to interact with binding partners, their allergic properties or their resulting modification/ alteration by compounds normally prescribed in a medical setting or their propensity to cause or alter disease states.
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