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The Office of High Performance Computing and Communications (OHPCC) serves as the focal point for the NLM High Performance Computing and Communications (HPCC) activities. OHPCC coordinates NLM HPCC planning, research and development activities with Federal, academic, and commercial organizations while collaborating with Lister Hill National Center for Biomedical Communications research branches and NLM Divisions in the development, operation, evaluation and demonstration of HPCC research programs and projects. The current major research activities of the office center on Evidence-Based Medicine, the HPCC Collaboratory, the Visible Human Project, and the 3D Informatics research program.