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U.S. National Institutes of Health
Scientific Programs
Last Updated: 03/05/10

Barriers to Development

The following are some barriers to development:

  • A profusion of small studies appears in the literature in the early phases of development, often with conflicting results, and techniques and data that cannot be compared.
  • Studies are often not designed with the power to address the hypotheses posed.
  • Many research groups appear to lack access to statistical collaborators.
  • Large numbers of well defined and annotated cases or specimens are needed.
  • There is often a need for specimens with long periods of follow-up.
  • There is a need for standardization of reagents and assay procedures to facilitate comparison of data from multiple studies.
  • Intellectual properties issues complicate the development of assays/tests that can be performed for acceptable costs.