Archive for the ‘Structural Biology’ Category


Improving Homology Modeling

Tuesday, Jan 29, 2013 10:54 AM EST by Ward Smith | 0 Comments

While the Protein Data Bank includes nearly 88,000 protein structures that were determined experimentally, there are millions more proteins whose structures are unknown. Comparative or homology modeling offers a powerful approach for leveraging solved structures to reveal important biological details about the others. Two efforts, both funded through the Protein Structure Initiative, are evaluating the [...]

Filed under: Funding Opportunities, Meetings/Events, Structural Biology
Permalink: https://loop.nigms.nih.gov/index.php/2013/01/29/improving-homology-modeling/

Crystallography Gets Support from United Nations, NIGMS

Tuesday, Dec 18, 2012 1:49 PM EST by Ward Smith | 0 Comments

Laue X-ray diffraction pattern of a single crystal of a dimeric hemoglobin taken at the BioCARS structural biology research center. Credit: Vukica Srajer, BioCARS/University of Chicago, and William Royer, Jr., University of Massachusetts Medical School As NIH Director Francis Collins recently noted on his blog, this year marks the 100th anniversary of the first experiment [...]

Filed under: Funding Opportunities, NIH, Resources, Structural Biology
Permalink: https://loop.nigms.nih.gov/index.php/2012/12/18/crystallography-gets-support-from-united-nations-nigms/

Invitation to Structure Determination Technologies Workshop

Monday, Sep 24, 2012 9:03 AM EST by Charles Edmonds | 0 Comments

We welcome structural biologists and biologists engaged in functional investigations that benefit from structural data to participate in our PSI:Biology Technologies Workshop at NIH on December 12, 2012. The workshop will focus on new technologies for high-throughput protein structure determination developed within our Protein Structure Initiative, which is now in a phase called PSI:Biology. Investigators [...]

Filed under: Meetings/Events, Structural Biology
Permalink: https://loop.nigms.nih.gov/index.php/2012/09/24/invitation-to-structure-determination-technologies-workshop/

Expression Plasmids and Empty Vectors Available

Thursday, Oct 13, 2011 1:49 PM EST by Jean Chin | 0 Comments

Great news for biochemists, biologists and structural biologists—more than 50,000 protein expression plasmids and almost 100 empty vectors are now available through the PSI:Biology-Materials Repository . This includes about 900 membrane protein plasmids, and we expect this number—plus that for human proteins—to grow in the coming months. The repository has carefully collected, maintained and annotated these [...]

Filed under: Resources, Structural Biology
Permalink: https://loop.nigms.nih.gov/index.php/2011/10/13/expression-plasmids-and-empty-vectors-available/

Register Now for the Protein Data Bank’s 40th Anniversary Symposium

Tuesday, Jul 19, 2011 11:28 AM EST by Ward Smith | 2 Comments

A special symposium marking the 40th anniversary of the Protein Data Bank (PDB) will be held this year at Cold Spring Harbor Laboratory in New York, October 28-30. It’s quite fitting that the meeting is being held here. It was a 1971 symposium at the laboratory titled “The Structure and Function of Proteins at the [...]

Filed under: Meetings/Events, Structural Biology
Permalink: https://loop.nigms.nih.gov/index.php/2011/07/19/register-now-for-the-protein-data-banks-40th-anniversary-symposium/

Early Notice: Reissue of RFA for Centers for AIDS-Related Structural Biology

Wednesday, Jun 8, 2011 12:50 PM EST by Michael Sakalian | 0 Comments

For 25 years, NIGMS has supported AIDS-related structural biology research that has provided fundamental insights into the replication of HIV and contributed toward the development of essential therapeutics. As Joe Gindhart discussed in an earlier Feedback Loop post, NIGMS marked the anniversary of this program with a special meeting in March. Many participants expressed excitement [...]

Filed under: Funding Opportunities, Structural Biology
Permalink: https://loop.nigms.nih.gov/index.php/2011/06/08/early-notice-reissue-of-rfa-for-centers-for-aids-related-structural-biology/

PSI Tools for Your Lab

Wednesday, Jan 12, 2011 8:49 AM EST by Ward Smith | 0 Comments

Over the course of its 10-year existence, the Protein Structure Initiative has supported the development of new technologies and methods that improve the throughput of protein structure determination. Many of them apply to the production of purified proteins for functional and structural studies, and you don’t need access to major research centers to use them. [...]

Filed under: Meetings/Events, Resources, Structural Biology
Permalink: https://loop.nigms.nih.gov/index.php/2011/01/12/psi-tools-for-your-lab/

New Funding Opportunity for Biologists to Collaborate on Structure Studies

Monday, Jun 28, 2010 10:15 AM EST by Ward Smith | 0 Comments

We have just issued a new “partnership” program announcement for researchers interested in a biological problem of significant scope to collaborate with structural biology researchers. The announcement is a part of the PSI:Biology initiative, which will apply high-throughput structure determination to a broad range of biological problems. Successful applicants will partner with researchers within the [...]

Filed under: Collaborative Research, Funding Opportunities, Structural Biology
Permalink: https://loop.nigms.nih.gov/index.php/2010/06/28/new-funding-opportunity-for-biologists-to-collaborate-on-structure-studies/

Register for 2010 Structure and Function Technologies Workshop

Tuesday, Feb 23, 2010 11:12 AM EST by Ward Smith | 2 Comments

Interested in new methods for improving the speed, cost and success of protein structure determination? Want to learn more about how to use structural and biophysical methods to functionally characterize macromolecules? Then consider attending our 10th annual Enabling Technologies in Structure and Function workshop from April 19-21, 2010, on the NIH campus in Bethesda, MD. [...]

Filed under: Meetings/Events, Structural Biology
Permalink: https://loop.nigms.nih.gov/index.php/2010/02/23/register-for-2010-structure-and-function-technologies-workshop/

New PSI:Biology Technology Development Opportunities

Thursday, Jan 7, 2010 8:37 AM EST by Ward Smith | 1 Comments

We have just issued new program announcements to develop technologies for protein modeling (PAR-10-075, PAR-10-076) and high-throughput structural biology research (PAR-10-074, PAR-10-073). These announcements are part of the PSI:Biology initiative that will apply high-throughput structure determination to a broad range of biological problems. Advances in comparative molecular modeling and high-throughput approaches will play an important [...]

Filed under: Funding Opportunities, Structural Biology
Permalink: https://loop.nigms.nih.gov/index.php/2010/01/07/new-psibiology-technology-development-opportunities/

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