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Project Number: 5U19CA148537-03   Sub-Project ID: 8846 Contact PI / Project Leader: HENDERSON, BRIAN E
Title: EPIDEMIOLOGICAL AND CLINICAL TRANSLATIONAL STUDIES POST GENOME-WIDE ASSOCIATION Awardee Organization: UNIV OF SOUTHERN CALIFORNIA
Description
Abstract Text:
Project 3: Epidemiological and Clinical Translational Studies Post Genome-Wide Association (GWAS) Project Leader: Rosalind Eeles Project Summary: The main focus of Project 3 is establishing a transdisciplinary collaborative network comprised of clinical scientists, epidemiologists, geneticists, and biostatisticians focusing on the transition from 'bench-side' research to 'bed-side' care. The CEC (Clinical ELLIPSE Consortium) will harmonize genetic, clinical, and environmental data from existing consortia, with over 35,000 prostate cancer cases, to evaluate gene, genegene, and gene-environmental effects on prostate cancer risk, including aggressive disease, recurrence, and mortality. The highly integrated ELLIPSE projects will facilitate the most up to date genetic evaluation by working closely with Project 1, identifying novel genetic candidates, and Project 2, providing biological insights on function. The assessment of genetic and environmental interactions will be evaluated for inclusion into a risk score as well as potentially providing directional input for Projects 1 and 2. All risk evaluations will be assessed in European, African American, and Japanese populations. Finally, this initial stage will provide the necessary guidance in developing useful and powerful risk prediction models for prostate cancer risk, including screening, outcome and treatment effects. These risk prediction models may have an immediate public health impact by providing clinicians with the necessary tools to improve clinical-decision making.
Public Health Relevance Statement:
Relevance: The main focus of this project is to establish a transdisciplinary network of highly innovative scientists investigating the impact of genetic, environmental, and effect modifiers (ie gene-gene and gene-environment) on prostate cancer risk in a multiethnic sample. In particular, this project will initiate the process the of going from the 'bench-side' to the 'bed-side' by developing risk prediction models needed in prostate cancer prediction, screening, progression, and treatments.
Project Terms:
Address; African; African American; Algorithms; Alleles; Applications Grants; Beds; bench to bedside; Biological; Biopsy; BRCA1 gene; burden of illness; cancer care; Cancer Detection; Cancer Family; cancer genetics; cancer prevention; cancer risk; cancer therapy; Caring; case control; Clinical; clinical application; clinical decision-making; Clinical Research; Clinical Treatment; clinically significant; Cohort Studies; Computer Simulation; Data; Data Collection; Detection; Development; Disease; DNA; drug development; Environment; Environmental Risk Factor; Epidemiological Factors; Epidemiologist; Epidemiology; ethnic minority population; European; European Union; Evaluation; Family history of; Family Study; feeding; Funding; gene environment interaction; General Population; Genes; Genetic; Genetic Counseling; Genetic Predisposition to Disease; genetic profiling; Genetic Risk; genetic variant; genome wide association study; Genotype; Germ-Line Mutation; Gleason Grade for Prostate Cancer; Grant; Health Benefit; Healthcare; high risk; improved; Individual; innovation; insight; interest; International Consortium on Prostate Cancer Genetics; Japanese Population; Malignant neoplasm of prostate; Manuscripts; Medical Oncologist; member; Minority; Minority Groups; Modeling; Mortality Vital Statistics; National Cancer Institute; Nature; novel; Oncologist; Other Genetics; Outcome; Pathway interactions; Patients; Penetrance; Pharmaceutical Preparations; Population; Population Attributable Risks; population based; Predisposition; Prevention; Prevention approach; Process; prostate cancer prevention; PSA level; public health medicine (field); Publications; Radiation Oncologist; Radiation therapy; Radiation Toxicity; Radical Prostatectomy; Recurrence; Research; research clinical testing; response; Risk; Risk-Taking; Sampling; Scientist; Screening for Prostate Cancer; Screening procedure; Side; Staging; Surgical Oncologist; Target Populations; Testing; tool; Toxic effect; Translating; translational study; treatment effect; Treatment Efficacy; Variant; Work



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