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Question ID: WS-96
Submitted by: Mark Pagel
June 27, 2011
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Question ID: WS-96
Submitted by: Mark Pagel
June 27, 2011
Should enzyme EXPRESSION or enzyme ACTIVITY be used to assess cancer biology and new chemotherapies? These chemotherapies include enzyme inhibitors and also drugs that hit upstream targets that control enzyme expression and/or activity. Enzymes are the "workhorses" of cancer biology and yet <20% of drugs and diagnostics target enzymes, perhaps because this provocative question remains unanswered.
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