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Question ID: WS-120
Submitted by: James Sherley
February 9, 2012
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Question ID: WS-120
Submitted by: James Sherley
February 9, 2012
What fraction of human cancers arise from initiating events in tissue stem cells? Of the different cell kinetics types in human tissues, stem cells have been proposed as the major target for carcinogenic mechanisms. However, it is a challenging proposition to evaluate this hypothesis. Knowing the distribution of cancer initiation rates across stem, committed progenitors, transiently amplifying cells, arrested cell tissue cell populations would impact many aspects of cancer control and cancer medicine, including the focus of early detection testing, cancer treatment regimens, cancer prevention strategies, and drug design.
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