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Question ID: WS-121
Submitted by: James Sherley
February 9, 2012
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Question ID: WS-121
Submitted by: James Sherley
February 9, 2012
Are carcinogenic mutation rates equally distributed across all tissue cell types? The immortal DNA strand hypothesis, first proposed by Cairns in 1975, posits that tissue stem cells have a lower mutation rate than other tissue stem cells. Recent advances in high-throughput and high-precision DNA sequencing makes it possible to now consider evaluating this hypothesis directly. Knowledge that such differences in mutation rate existed would inspire investigations to understand their cause; and it would suggest a new basis for understanding human carcinogenic mechanisms and for developing new approaches to reducing cancer risk.
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