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Protein Structure Initiative

Enabling High-Throughput Structural Biology and Structural Genomics

Protein Structure Initiative (PSI)

The Protein Structure Initiative (PSI) began in 2000 with an initial goal to make the three-dimensional, atomic-level structures of most proteins easily obtainable from knowledge of their corresponding DNA sequences. During the current PSI:Biology phase, highly organized networks of investigators are applying the new paradigm of high-throughput structure determination, which was successfully developed during the earlier phases of the PSI, to study a broad range of important biological and biomedical problems.

Expected benefits from the PSI include: structural descriptions to help researchers discover the functions of proteins, design experiments and solve other key biomedical problems; faster identification of promising new structure-based medicines; better therapeutics for treating both genetic and infectious diseases; and development of technology and methodology for protein production and crystallography.

The PSI actively engages the scientific community in the selection of proteins for structure determination and is increasing its outreach, accessibility and impact on biomedical research via the PSI:Biology-Nature Structural Biology Knowledgebase Link to external Web site, a continually updated portal to PSI data, resources and latest developments. Biological material resources generated by the PSI are shared with the scientific community through the PSI:Biology Materials Repository Link to external Web site and through collaborations with PSI investigators.


Learn about the next phase of the PSI.

Background Information

Discover more about the PSI and its history, including the pilot and production phases.

Funding Opportunities

View PSI-related listings from the NIH Guide for Grants and Contracts, the official publication for NIH research grant policies, guidelines and funding opportunities.


Read PSI announcements and results.


Find out about PSI meetings.


Read PSI meeting reports.

Contact Us

Reach PSI program staff.

This page last reviewed on January 25, 2013