Section on Epithelial and Retinal Physiology and Disease

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Publications

Selected Background Reviews (Retinal Pigment Epithelium)

Gallemore, R.P., Hughes, B.A., and S. S. Miller (1998). Light-induced responses of the retinal pigment epithelium. Retinal Pigment Epithelium: Current Aspects of Function and Disease, eds: Marmor, M.F. and Wolfensburger T.J., Oxford University Press, pp. 175-198.

Hughes, B.A., Gallemore, R.P., and S. S. Miller (1998). Transport Mechanisms in the retinal pigment epithelium. Retinal Pigment Epithelium: Current Aspects of Function and Disease, eds: Marmor, M.F. and Wolfensburger T.J, Oxford University Press, pp. 103-134.

Peterson, W.M., Quong, J.N. and S.S.Miller (1998). Mechanisms of fluid transport in retinal pigment epithelium. The Third Great Basin Visual Science Symposium on Retinal Research, Volume III: 34-42.

Maminishkis A, Miller SS (2010). Experimental Models for Study of Retinal Pigment Epithelial Physiology and Pathophysiology. JoVE. http://www.jove.com/index/Details.stp?ID=2032, doi: 10.3791/2032

Miller, S.S., Maminishkis, Li, R., and J. Adijanto (2010). Retinal Pigment Epithelium: Cytokine Modulation of Epithelial Physiology, (Encyclopedia of the Eye, Chapter 184: Phototransduction: RPE transport Retina | Phototransduction: RPE transport ELSEVIER ). Hardbound, 2540 pages, publication date: MAY-2010, ISBN-13: 978-0-12-374198-1, Imprint: ACADEMIC PRESS.

Selected Papers

Miller, S.S., Hughes, B.A. and T.E. Machen (1982). Fluid Transport Across the Retinal Pigment epithelium is Inhibited by Cyclic AMP. Proceedings of the National Academy of Science, 79:2111-2115.

Hughes, B.A., Miller, S.S. and T.E. Machen (1984). Effects of cAMP on Fluid Absorption and Ion Transport Across Frog Retinal Pigment Epithelium: Measurement in the Open-Circuit State. Journal of General Physiology, 83:875-899.

Adorante, J.S. and S.S. Miller (1990). Potassium Dependent Volume Regulation in Retinal Pigment Epithelium is Mediated by Na, K, Cl Cotransport. Journal of General Physiology, 96:1153-1176.

Joseph, D.P. and S.S. Miller (1991). Apical and Basal Membrane Ion Transport Mechanisms in Bovine Retinal Pigment Epithelium. Journal of Physiology, 435:439-463.

Lin, H. and S.S. Miller (1991). pHi Regulation in Frog Retinal Pigment Epithelium: Two Apical Membrane Mechanisms. American Journal of Physiology 261:C132-C142.

Edelman, J.L. and S.S. Miller (1991). Epinephrine Stimulates Fluid Absorption Across Bovine Retinal Pigment Epithelium. Investigative Ophthalmology and Visual Science 32:3033-3040.

Joseph, D. and S.S. Miller (1992). Alpha-1 Adrenergic Modulation of K and Cl Transport In Bovine Retinal Pigment Epithelium. Journal of General Physiology 99:263-290.

Quinn, R., and S.S. Miller (1992). Ion Transport Mechanisms in Native Human Retinal Pigment Epithelium. Investigative Ophthalmology and Visual Science 33:3513-3527.

Lin, H., Kenyon, E. and S.S. Miller (1992) Na-Dependent pHi Regulatory Mechanisms in Native Human Retinal Pigment Epithelium. Investigative Ophthalmology and Visual Science 33:3528-3538.

Lin, H. and S.S. Miller (1994). I. pHi-dependent Cl-HCO3 Exchange at the Basolateral Membrane of Frog Retinal Pigment Epithelium. American Journal of Physiology 266:C935-C945.

Edelman, J.L., Lin, H. and S.S. Miller (1994). II. Acidification stimulates chloride and fluid absorption across frog pigment epithelium. American Journal of Physiology (cell) 266:C946-C956.

Edelman, J.L., Lin, H. and S.S. Miller (1994). III. Potassium-induced chloride secretion across the frog retinal pigment epithelium. American Journal of Physiology (cell) 266:C957-C966.

Kenyon, E., Yu, K., LaCour, M. and S.S. Miller (1994). Lactate transport mechanisms at the apical and basolateral membranes of bovine retinal pigment epithelium. American Journal of Physiology 267: C1561-C1573.

Bialek, S., Joseph, D.P. and S.S. Miller (1995). The delayed basal hyperpolarization of the bovine retinal pigment epithelium: Mechanisms of generation. Journal of Physiology (London) 484: 53-67.

Kenyon, E., Maminishkis, A. Joseph D.P. and S.S. Miller (1997). Apical and basolateral membrane mechanisms that regulate pHi in bovine retinal pigment epithelium. American Journal of Physiology 273: (Cell Physiol. 42) C456 - C472.

Peterson, W.M., Meggyesy, C., Yu, K., and S.S. Miller (1997). Extracellular ATP activates calcium signaling, ion and fluid transport in retinal pigment epithelium. The Journal of Neuroscience 17: 2324-2337.

Quinn, R.H., Quong, J.N., and S.S. Miller (2001). Adrenergic receptor activated ion transport in native human fetal retinal pigment epithelium. Investigative Ophthalmology & Visual Science 42:255-264.

Maminishkis, A., Jalickee, S., Rymer, J., Yerxa, B.R., Peterson, W.M. and S.S. Miller (2002). The P2Y2 receptor agonist INS37217 stimulates RPE fluid transport in vitro and retinal reattachment in rat. Investigative Ophthalmology & Visual Science 43: 3555-3566.

Wang, F., Rendahl, K.G., Manning, W.C., Quiroz, D., Coyne, M. and S.S. Miller (2003).Adeno-Associated Virus Mediated Expression of Vascular Endothelial Growth Factor Induced Choroidal Neovascularization in Rat. Investigative Ophthalmology & Visual Science 44: 781-790.

Voloboueva, L.A., Liu, J., H. Suh, J.H., Ames, B.N., and S.S. Miller (2005). (R)-α-Lipoic Acid Protects Retinal Pigment Epithelial Cells from Oxidative Damage. Investigative Ophthalmology & Visual Science 47: 3612-3624.

Maminishkis, A., Chen, S., Jalickee, S., Banzon, T., Shi, G., Ehalt, T., Wang, F.E., Hammer, J.A., and S. S. Miller (2006). Confluent monolayers of cultured human fetal retinal pigment epithelium (hfRPE) exhibit morphology and physiology of native tissue. Investigative Ophthalmology & Visual Science 46: 4302-4310.

Jia, L., Liu, Z., Sun, L., Miller, S.S., Ames, B.N., Cotman, C.W., and J. Liu (2007). Acrolein, a toxin in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in retinal pigment epithelial cells: protection by (R)-α-lipoic acid. Investigative Ophthalmology & Visual Science 48: 339-348.

F.E. Wang, G.Shi, M.R. Niesman D.A. Rewolinski, S.S. Miller (2007). Receptor Tyrosine Kinase Inhibitors AG013764 and AG013711 Reduce Choroidal Neovascularization in Rat Eye. Experimental Eye Research 84: 922-933.

Li, R., Maminishkis, A., Wang, F.E., S.S. Miller (2007). PDGF-C and -D Induced Proliferation/Migration of Human RPE is Abolished by Inflammatory Cytokines. Investigative Ophthalmology & Visual Science 48: 5722 - 5732.

Shi, G., Maminishkis, A., Banzon, T., Jalickee, S., Li, R., Hammer, J., and S.S. Miller (2008). Control of Chemokine Gradients by the Retinal Pigment Epithelium. Investigative Ophthalmology & Visual Science 49: 4620 - 4630.

Economopoulou, M., Hammer, J., Wang, F., Fariss, R., Maminishkis, A., and S.S.Miller (2009). Expression, Localization, and Function of Junctional Adhesion Molecule-C (JAM-C) in Human Retinal Pigment Epithelium. Investigative Ophthalmology & Visual Science 50:1454-1463.

Adijanto, J., Jalickee, S., Banzon, T., Wang, NS, and S.S. Miller (2009). CO2 - induced Ion and Fluid Transport in Human Retinal Pigment Epithelium. Journal of General Physiology, 133: 602-622.

Li, R., Maminishkis,A., Zahn, G.,, Vossmeyer,D., and S.S. Miller (2009). Integrin α5β1 Mediates Attachment, Migration, and Proliferation in Human Retinal Pigment Epithelium: Relevance for Proliferative Retinal Disease. Investigative Ophthalmology & Visual Science, 50: 5988-5996.

Li, R., Maminishkis, A., Banzon, T., Wan, Q., Jalickee, S., Chen S. and S.S. Miller (2009). IFNγ Regulates Retinal Pigment Epithelial Fluid Transport. Am J Physiol Cell Physiol 297: C1452–C1465, 2009.

Wang, F., Zhang, C.*, Maminishkis, A., Dong.L., Zhi, C., Rong Li, Jing Zhao, J., Majerciak, V., Gaur, AB., Chen, S, and S. S. Miller (2010). MicroRNA-204/211 Alters Epithelial Physiology 2010 May;24(5):1552-71.) Epub 2010 Jan 7.

Strunnikova, N.V., Barb, J., Chen, W., Maminishkis, A., Wang, F., Zhi, C., Sergeev, Y., Stambolian, D., Edwards, A.O., Abecasis, G. Swaroop, A., Munson, P.J., and S.S. Miller (2010). Transcriptome Analysis and Molecular Signature of Human Retinal Pigment Epithelium. Human Molecular Genetics, Jun 15;19(12):2468-86. Epub 2010 Apr 1.

Bharti, K., Miller, SS., and H. Arnheiter (2010). The new paradigm: Retinal pigment epithelium cells generated from embryonic stem cells or induced pluripotent cells. Pigment Cell Melanoma Res. 2010 Sep 15. [Epub ahead of print]