CCR’s top scientific advances are selected each year by CCR senior staff. These may be promoted in one or more of the following ways:
The advances selected for 2011 are shown below.
Advances in Blood Cancers
Approval of romidepsin for peripheral T-cell lymphoma – submission by Susan Bates, MD
Reference(s): Blood. 2011 Jun 2;117(22):5827-34
Gain-of-function mutations in IL-7R cause T-ALL – submission by Scott Durum, PhD
Reference(s): Nature Genetics. 2011 Sep 4;43(10):932-9
Discovery of NK cell enteropathy – submission by Elaine Jaffe, MD
Reference(s): Blood. 2011 Feb 3;117(5):1447-52
Learning from cancer precursors – submission by Ola Landgren, MD, PhD
Reference(s): JAMA. 2010 Dec 1;304(21):2397-404
Oncogenic MYD88 signaling in the ABC subtype of diffuse large B cell lymphoma and cooperative epigenetic modulation by cancer amplicon genes – submission by Louis Staudt, MD, PhD
Reference(s): Nature. 2011; 470:115-119; Cancer Cell. 2010 Dec 14;18(6):590-605
Advances in Biomarkers
Biodosimeter for ionizing radiation exposure – submission by William Bonner, PhD
Reference(s): PLoS One. 2010 Nov 23;5(11):e15544
Advances in Cancer Stem Cells
In vitro generation of human cancer stem cells – submission by Tom Misteli, PhD
Reference(s): Nature Cell Biology. 2011 Aug 21;13(9):1051-61
Advances in Chromosome Biology
Molecular mechanism of enhancer function in mammalian cells – submission by Gordon Hager, PhD
Reference(s): Mol Cell. 2011; 43, 145-155; Nature Genetics. 2011; 43, 264-268; Cell. 2011; 146, 544-554. EMBO J. 2011; 30, 3028-3039
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing – submission by Shalini Oberdoerffer, PhD
Reference(s): Nature. 2011 Oct 2. doi: 10.1038/nature10442
Advances in Genetics
Dissecting the molecular genetics of thyroid carcinogenesis by using genetically engineered mouse models – submission by Sheue-yann Cheng, PhD
Reference(s): Oncogene. 2011 Jul 28;30(30):3381-90; Am J Cancer Res. 2011 Jan 1;1(1):1-13; J Mol Endocrinol. 2011 Jun 9;46(3):233-44
Novel function of BRCA1 in the epigenetic suppression of an oncogenic microRNA – submission by Shyam Sharan, PhD
Reference(s): Nature Medicine. 2011 Sep 25;17(10):1275-82
Advances in Imaging
Photoimmunotherapy for cancer – submission by Peter Choyke, MD
Reference(s): Nature Medicine. in press
Advances in Melanoma
Interferon-gamma links UV to melanocyte activation and promotes melanomagenesis – submission by Glenn Merlino, PhD
Reference(s): Nature. 2011; 469: 548-553
A comprehensive view of melanoma’s genetic landscape – submission by Steve Rosenberg, MD, PhD
Reference(s): Nature Genetics. 2011 May;43(5):442-6
Advances in Prostate Cancer
FOXO3 programs tumor-associated dendritic cells to become tolerogenic in human and murine prostate cancer – submission by Andy Hurwitz, PhD
Reference(s): J Clin Invest. 2011; 121(4): 1361-72
Increased cancer detection rates using fusion-guided prostate biopsy system – submission by Bradford Wood, MD with P. Choyke, MD, P. Pinto, MD, W. M. Linehan, MD and M. Merino, MD
Reference(s): J Urol. 2011 Mar;185(3):815-20; BJU Int. 2011 Jan;107(1):53-7; Radiology. 2011 Feb;258(2):488-95; J Urol. 2011 Oct;186(4):1281-5
Advances in Signaling Pathways and Cancer Biology
p53 regulates a telomere-capping protein TRF2 to form a positive feedback loop that orchestrates the telomere-initiated DNA damage signaling to cellular senescence – submission by Curtis Harris, MD
Reference(s): Nature Cell Biology. 2010 Dec;12(12):1205-12; Aging (Albany NY). 2011;3(1):26-32
Link between rare cancer to cell oxygen deficiency – submission by Lee Helman, MD with Su Young Kim, MD, PhD
Reference(s): Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):314-8
The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases metabolic propensities and lowers cellular iron levels – submission by W. Marston Linehan, MD
Reference(s): Cancer Cell. 2011 Sep 13;20(3):315-27
Advances in Virology
Differential microRNA regulation of HLA-C expression and its association with HIV control – submission by Mary Carrington, PhD with Howard Young, PhD
Reference(s): Nature. 2011; 472:495-498
Recombinant origin of retrovirus XMRV – submission by Vinay Pathak, PhD
Reference(s): Science. 2011; 333: 97-101
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