Biologic Specimen and Data Repository Information Coordinating Center
Home > Studies > PREMIER: Lifestyle Interventions for Blood Pressure Control

Resources Available

Specimens and Study Datasets

Materials Available

PLASMA 6,286
SERUM 9,725
URINE 7,213

Study Documents

PDF Data Dictionary (PDF - 512.8 KB)
PDF Data Collection Forms (PDF - 1.6 MB)
PDF Food Groups (PDF - 23.5 KB)
PDF MOP Clinical (PDF - 875.1 KB)
PDF MOP Intervention (PDF - 565.4 KB)
PDF Publications (PDF - 22.5 KB)

Persons using assistive technology may not be able to fully access information in the study documents. For assistance, Contact BioLINCC and include the web address and/or publication title in your message.

If you need help accessing information in different file formats such as PDF, XLS, DOC, see Instructions for Downloading Viewers and Players.

PREMIER: Lifestyle Interventions for Blood Pressure Control

Clinical Trials URL:
Study Type: Clinical Trial
Prepared on May 20, 2009
Last Updated on May 8, 2006
Study Dates: 1998-2004
Consent: Restricted Consent
Consent Restrictions: Restrictions are related to genetic/non-genetic specimen use by research topic.
Commercial Use Restrictions: No
NHLBI Division: DCVS
Collection Type: Open BioLINCC Study - See bottom of this webpage for request information


To determine the effect on blood pressure (BP) of 2 multicomponent, behavioral interventions.


Weight loss, sodium reduction, increased physical activity, and limited alcohol intake are established recommendations that reduce BP. The Dietary Approaches to Stop Hypertension (DASH) diet also lowers BP. To date, no trial has evaluated the effects of simultaneously implementing these lifestyle recommendations.


Randomized trial with enrollment at 4 clinical centers (January 2000-June 2001) among 810 adults (mean [SD] age, 50 [8.9] years; 62% women; 34% African American) with above-optimal BP, including stage 1 hypertension (120-159 mm Hg systolic and 80-95 mm Hg diastolic), and who were not taking antihypertensive medications.


Randomized controlled clinical trial that tested two behavioral interventions compared with an advice-only group over a period of 18 months. The two interventions promoted established recommendations that reduce BP. One intervention in addition promoted the DASH diet, which is rich in fruits, vegetables, and low-fat dairy products, and low in saturated fat, total fat, and cholesterol.


Individuals with above-optimal BP, including stage 1 hypertension, can make and largely sustain multiple lifestyle changes. These lifestyle changes lower BP, improve BP control, and may reduce cardiovascular disease risk. (JAMA 2003;289:2083-2093; Ann Intern Med 2006;144:485-495).