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Residual Tissue Repository Program Accomplishments & Publications
Revised August, 2009

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Program Accomplishments

Residual Tissue Repository (RTR) program accomplishments to date include publications based on tissue microarrays (TMAs) from breast, colorectal, and pancreatic tumors. From a subset of incident colorectal cancer cases recorded in the Hawaii registry for 1995 (n=286/603; 47%), Hernandez et al. observed that cytokeratins 20 and 7 were over-expressed in malignant versus histologically normal tissue. The TMA cases were similar to non-TMA cases with respect to age, gender, race/ethnicity, anatomic site and survival, but differed from all cases in the population with respect to stage and treatment.

In another reported study, Takikita et al. utilized RTR specimens from the Iowa, Hawaii, and Los Angeles county registries to create a population-based, pancreatic cancer TMA from 161/13,650 recorded cases (1.2%), with over-representation of African-American (12% vs. 9%) and Asian-Pacific Islander (40% vs. 14%) cases compared to the registry populations at large. Multiple core samples were obtained from malignant epithelial and benign normal tissues for each case. Candidate biomarkers were analyzed with respect to survival time from diagnosis to death, using multivariable Cox proportional hazard regression models. Tumor mucin expression (MUC1, MUC2 and MUC5AC) was found to be associated with shorter survival time, even after adjusting for gender, age, race, stage of disease, pancreatic origin versus metastatic site, and ever versus never surgical or radiation treatment. Histologic features and biomarker patterns differed by race, but the investigators acknowledged that the TMA did not include adequate case numbers from diverse population subgroups to provide robust inferences by race/ethnicity.

Single registries within the SEER RTR program have also developed valuable biospecimens resources. These biospecimens have been used in studies of lung, breast, and hematopoietic cancers. The RTR Committee intends to expand the contribution of this population-based biospecimen resource through collaborative cancer research. In keeping with this objective, current and proposed RTR projects are examining biospecimens from SEER cases with a variety of tumor types including primary central nervous system lymphoma, AIDS/HIV-associated cancers, Burkitt lymphoma, and breast, ovarian, colorectal, hepatocellular, and HPV-related cancers.

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Publications

Anderson WF, Luo S, Chatterjee N, Rosenberg PS, Matsuno RK, Goodman MT, Hernandez BY, Reichman M, Dolled-Filhart M, O'Regan R, Garcia-Closas M, Perou CM, Jatoi I, Cartun RW, Sherman ME. Human epidermal growth factor receptor-2 and estrogen receptor expression, a demonstration project using the residual tissue repository of the Surveillance, Epidemiology, and End Results (SEER) Program. Breast Cancer Res Treat 2008 Feb 7. [Epub ahead of print]

Cortessis V, Cozen W, Penson DF, Quinn DI, Sibug-Saber M, Martin, SE: Introduction of a new germ cell tumor tissue bank resource. 6th Copenhagen Workshop on In Situ Testis and Germ Cell Cancer, Copenhagen, Denmark, October 26-29, 2006. (Meeting Abstract)

Glaser SL, Culley ML, Clarke CA, Keegan TH, Chang ET, Shema SJ, Craig FE, Diguiseppe JA, Dorfman RF, Mann RB, Anton-Culver H, Ambinder RF. Racial/ethnic variation in EBV-positive classical Hodgkin lymphoma in California populations. Int J Cancer 2008 Oct 1;123(7):1499-507.

Goodman MT, Hernandez BY, Hewitt S, Lynch CF, Cote TR, Frierson HF Jr, Moskaluk CA, Killeen JL, Cozen W, Key CR, Clegg L, Reichman M, Hankey BF, Edwards B. Tissues from population-based cancer registries: a novel approach to increasing research potential. Hum Pathol 2005 Jul;36(7):812-20.

Hernandez BY, Frierson HF, Moskaluk CA, Li YJ, Clegg L, Cote TR, McCusker ME, Hankey BF, Edwards BK, Goodman MT. CK20 and CK7 protein expression in colorectal cancer: Demonstration of the utility of a population-based tissue microarray. Hum Pathol 2005 Mar;36(3):275-81.

Lynch CF, Kutza JA, Kelley SL, Platz CE. Procurement of population-based cancer tissue in Iowa. Mod Pathol 1999;12(4):422-26.

Takikita M, Altekruse S, Lynch CF, Goodman MT, Hernandez BY, Green M, Cozen W, Cockburn M, Saber MS, Topor M, Zeruto C, Abedi-Ardekani B, Reichman ME, Hewitt SM. Associations between selected biomarkers and prognosis in a population-based pancreatic cancer tissue microarray. Cancer Res 2009 Apr 1;69(7):2950-55.

Thyagarajan B, Anderson KE, Kong F, Selk FR, Lynch CF, Gross MD. New approaches for genotyping paraffin wax embedded breast tissue from patients with cancer: the Iowa women’s health study. J Clin Pathol 2005 Sep;58(9):955-61.

Thyagarajan B, Anderson KE, Folsom AR, Jacobs D, Lynch CF, Bargaje A, Khaliq W, Gross MD. No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women’s Health Study. Cancer Detect Prev 2006;30(4):313-21.

Tsou JA, Galler JS, Siegmund KD, Laird PW, Turla S, Cozen W, Hagen JA, Koss MN, Laird-Offringa IA. Identification of sensitive and specific DNA methylation markers for lung adenocarcinoma. Mol Cancer 2007 Oct 29;6:70.

Wang SS, Davis S, Hartge P, Cozen W, Severson RK, Cerhan JR, Rothman N. Chromosomal aberrations in peripheral blood lymphocytes and risk for non-Hodgkin lymphoma. Natl Cancer Inst Monogr 2008;39:78-82.

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