List of Supported INDs/DMFs
|
Cancer Drugs
|
NSC Number
|
IND/MF
|
IND/DMF Number
|
Date
|
Notes
|
|
Merbarone
|
(NSC 336628)
|
IND
|
27,656
|
(12/85)
|
|
|
Flavone Acetic Acid
|
(NSC 347512)
|
IND
|
26,886
|
(02/86)
|
|
|
Deoxyspergualin
|
(NSC 356894)
|
IND
|
28,053
|
(03/86)
|
|
|
Piroxantrone
|
(NSC 349174)
|
IND
|
29,720
|
(02/87)
|
|
|
Fazarabine
|
(NSC 281272)
|
IND
|
29,722
|
(02/87)
|
|
|
Ipomeanol
|
(NSC 349438)
|
IND
|
31,371
|
(03/88)
|
|
|
Hepsulfam
|
(NSC 329680)
|
IND
|
32,057
|
(09/88)
|
|
|
Chloroquinoxolinesulphonamide (CQS)
|
(NSC 339004)
|
IND
|
32,123
|
(02/89)
|
|
|
Buthionine Sulfoximine/BCNU (BSO)
|
(NSC 326231/40996)
|
IND
|
32,981
|
(06/89)
|
|
|
Buthionine Sulfoximine/CBDCA
|
(NSC 326231/241240)
|
IND
|
32,981
|
(/89)
|
|
|
Pyrazine Diazohydroxide (PZDH)
|
(NSC 361456)
|
IND
|
33,930
|
(11/89)
|
|
|
Pyrazoloacridine
|
(NSC 366140)
|
IND
|
36,325
|
(02/91)
|
|
|
Cyclopentenyl Cytosine (CPEC)
|
(NSC 375575)
|
IND
|
38,156
|
(11/91)
|
|
|
Carboxyaminoimidazole (CAI)
|
(NSC 609974)
|
IND
|
38,583
|
(12/91)
|
|
|
Fostriecin, Sodium
|
(NSC 339638)
|
IND
|
39,667
|
(05/92)
|
|
|
TNP-470 (Fumagillin Analog)
|
(NSC 642492)
|
IND
|
40,065
|
(07/92)
|
|
|
9-Amino[20S]camptothecin
|
(NSC 603071)
|
IND
|
41,083
|
(11/92)
|
|
|
Penclomedine
|
(NSC 338720)
|
IND
|
43,409
|
(09/93)
|
|
|
Bizelesin
|
(NSC 615291)
|
IND
|
44,170
|
(12/93)
|
|
|
O6-Benzylguanine/BCNU (O6BG)
|
(NSC 637037)
|
IND
|
45,789
|
(07/94)
|
|
|
Flavopiridol
|
(NSC 649890)
|
IND
|
46,211
|
(09/94)
|
|
|
Rebeccamycin Tartrate
|
(NSC 655649)
|
IND
|
46,941
|
(12/94)
|
|
|
Perillyl Alcohol
|
(NSC 641066)
|
IND
|
47,472
|
(03/95)
|
|
|
Tributyrin
|
(NSC 661583)
|
IND
|
47,776
|
(04/95)
|
|
|
Dolastatin 10
|
(NSC 376128)
|
IND
|
48,119
|
(06/95)
|
|
|
UCN-01
|
(NSC 638850)
|
IND
|
49,169
|
(11/95)
|
|
|
Quinocarmycin Analog DX-52-1
|
(NSC 607097)
|
IND
|
49,467
|
(12/95)
|
|
|
KRN5500
|
(NSC 650426)
|
IND
|
51,682
|
(10/96)
|
|
|
Bizelesin (Bone Marrow)
|
(NSC 615291)
|
IND
|
51,724
|
(11/96)
|
|
|
Depsipeptide
|
(NSC 630176)
|
IND
|
51,810
|
(11/96)
|
|
|
Penclomedine (Oral)
|
(NSC 338720)
|
IND
|
43,409
|
(12/96)
|
|
|
Cordycepin/Deoxycoformycin
|
(NSC 63984/218321)
|
IND
|
52,325
|
(01/97)
|
|
|
Ecteinascidin 743
|
(NSC 648766)
|
DMF
|
12,344
|
(01/97)
|
1,2
|
|
COL-3
|
(NSC 683551)
|
IND
|
54,600
|
(11/97)
|
|
|
EF-5
|
(NSC 684681)
|
IND
|
54,956
|
(12/97)
|
|
|
PS-341
|
(NSC 681239)
|
IND
|
56,515
|
(07/98)
|
3
|
|
G3139
|
(NSC 683428)
|
|
|
|
4
|
|
SarCNU
|
(NSC 364432)
|
IND
|
56,822
|
(09/98)
|
|
|
17-Allylaminogeldanamycin
|
(NSC 330507)
|
IND
|
57,966
|
(04/99)
|
|
|
Pc-4 (Silicone Phthalocyanine)
|
(NSC 676418)
|
DMF
|
14,140
|
(05/99)
|
1,5
|
|
PS-341
|
(NSC681239)
|
IND
|
NA
|
(06/99)
|
|
|
G3139
|
(NSC 683428)
|
IND
|
58,842
|
(08/99)
|
|
|
Tempol
|
(NSC 142784)
|
IND
|
59,451
|
(12/99)
|
6
|
|
2-Methoxyestradiol
|
(NSC 659853)
|
IND
|
59,715
|
(01/00)
|
7
|
|
Pyroxamide
|
(NSC 696085)
|
DMF
|
14,722
|
(03/00)
|
1,8
|
|
Benzoylphenylurea
|
(NSC 639829)
|
IND
|
61,039
|
(10/00)
|
|
|
MS-275
|
(NSC 706995)
|
IND
|
61,198
|
(11/00)
|
|
|
Biological Agents
|
NSC Number
|
IND/MF
|
IND/DMF Number
|
Date
|
Notes
|
|
LMB-1 [B3-NLysPE38]
|
(NSC 651311)
|
IND
|
5,017
|
(03/93)
|
|
|
r-V-CEA(180k)
|
(NSC 649024)
|
IND
|
5,041
|
(04/93)
|
|
|
r-V-MAGE1
|
(NSC 658894)
|
IND
|
5,571
|
(05/94)
|
|
|
LMB-7 [B3-(Fv)PE38]
|
(NSC 658931)
|
IND
|
5,863
|
(11/94)
|
|
|
MART-1 Peptide/ISA
|
(NSC 672643)
|
IND
|
5,909
|
(12/94)
|
|
|
PCLUS 3-18MN, 6.1-18MN, P-18MN/ISA [HIV]
|
(NSC 658895, 663850)
|
IND
|
5,924
|
(12/94)
|
|
|
ras 5-17 Peptides C12, V12, D12 /Detox
|
(NSC 667937, 665824, 667938)
|
IND
|
5,925
|
(12/94)
|
|
|
r-V-CEA(70k)
|
(NSC 649203)
|
IND
|
6,143
|
(05/95)
|
|
|
ras Proteins (C12, D12, V12)/QS21
|
(NSC 674779, 674780, 674781)
|
IND
|
6,335
|
(10/95)
|
|
|
r-Ad2-MART-1
|
(NSC 674304)
|
IND
|
6,372
|
(11/95)
|
|
|
r-Ad2-gp100
|
(NSC 674305)
|
IND
|
6,586
|
(03/96)
|
|
|
LMB-2 [Anti-Tac(Fv)-PE38]
|
(NSC 676422)
|
IND
|
6,662
|
(05/96)
|
|
|
r-V-PSA
|
(NSC 659642)
|
IND
|
6,698
|
(06/96)
|
|
|
LMB-7 (Intrathecal Protocol)
|
(NSC 658931)
|
IND
|
5,863
|
(01/97)
|
|
|
r-V-B7.1
|
(NSC 674306)
|
BB-MF
|
7,267
|
(08/97)
|
9
|
|
erb-38 [e23(dsFv)PE38]
|
(NSC 683039)
|
IND
|
7,373
|
(10/97)
|
|
|
LMB-9 [B39dsFv)PE38]
|
(NSC 691236)
|
IND
|
7,697
|
(05/98)
|
|
|
BL22 [RFB4(dsFv)PE38]
|
(NSC 691237)
|
IND
|
8,099
|
(12/98)
|
|
|
Endostatin
|
(NSC704805)
|
IND
|
8,454
|
(06/99)
|
7
|
|
Endostatin
|
(NSC704805)
|
IND
|
8,586
|
(09/99)
|
|
|
IL-12 + IL-2
|
(NSC672423 & 373364)
|
IND
|
8,748
|
(12/99)
|
|
|
r-V-CEA/TRICOM
|
(NSC710067)
|
IND
|
9,306
|
(09/00)
|
|
|
AIDS Drugs
|
NSC Number
|
IND/MF
|
IND/DMF Number
|
Date
|
Notes
|
|
Dideoxycytidine (ddC)
|
(NSC 606170)
|
IND
|
28,975
|
(09/86)
|
|
|
Dideoxyadenosine (ddA)
|
(NSC 98700)
|
IND
|
30,971
|
(11/87)
|
|
|
Dideoxyinosine (ddI)
|
(NSC 612049)
|
IND
|
31,714
|
(06/88)
|
|
|
3TC [In Part]
|
(NSC 620753)
|
IND
|
Glaxo
|
|
10
|
|
A-77003
|
(NSC 640441)
|
IND
|
Abbott
|
|
11
|
|
KNI-272
|
(NSC 651714)
|
IND
|
44,276
|
(12/93)
|
|
|
?-F-ddA
|
(NSC 613792)
|
IND
|
49,628
|
(12/95)
|
|
|
Isis 5320
|
(NSC 665353)
|
IND
|
51,681
|
(10/96)
|
12
|
|
|
|
DMF
|
12,591
|
(07/97)
|
1
|
|
(+)-Calanolide A
|
(NSC 650886)
|
IND
|
52,317
|
(05/97)
|
13
|
|
Other Agents
|
NSC Number
|
IND/MF
|
IND/DMF Number
|
Date
|
Notes
|
|
FP-TZTP (PET Imaging No. 01)
|
N/A, NIH CC-PET
|
IND
|
54,781
|
(12/97)
|
6
|
|
MeFBAWAY (PET Imaging No. 0 2)
|
N/A, NIH CC-PET
|
IND
|
Not Filed Yet
|
|
14
|
|
FCWAY (PET Imaging No. 03)
|
N/A, NIH CC-PET
|
IND
|
59,163
|
(11/99)
|
6
|
|
F-Paclitaxel (PET Imaging No. 04)
|
N/A, NIH CC-PET
|
IND
|
Not Filed Yet
|
|
14
|
|
FPWAY (PET Imaging No. 05)
|
N/A, NIH CC-PET
|
IND
|
Not Filed Yet
|
|
14
|
1 Drug Master File (DMF) filed with the FDA.
2 IND Number 50,286 filed by PharmaMar, Inc.
3 IND filed by ProScript, Inc.
4 IND filed by Genta Pharmaceuticals, NCI to file DMF and cross-file on Genta IND.
5 IND will be filed by Case Western Reserve University.
6 IND filed by NIH Clinical Center.
7 IND filed by EntreMed.
8 IND will be filed by Memorial Sloan Kettering Cancer Center.
9 Biological Master File (BB-MF) filed with FDA.
10 IND filed by Glaxo Pharmaceuticals.
11 Abbott Laboratories filing in The Netherlands.
12 IND filed by Isis Pharmaceuticals.
13 IND Filed by Sarawak MediChem Pharmaceuticals.
14 IND will be filed by the NIH Clinical Center.
