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Gain-of-Function Research on Highly Pathogenic Avian Influenza H5N1 Viruses:An International Consultative Workshop
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THE INTERSECTION OF SCIENCE AND SECURITY: A CASE STUDY APPROACH- December 9, 2011
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RESPONSIBLE CONDUCT OF RESEARCH SESSION - MARCH, 16, 2011
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STRENGTHENING THE CULTURE OF RESPONSIBILITY WITH RESPECT TO DUAL USE RESEARCH AND BIOSECURITY- November 1, 2010
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DOES YOUR RESEARCH RAISE SECURITY CONCERNS? STRATEGIES FOR PROMOTING RESPONSIBLE RESEARCH IN THE LIFE SCIENCES- September 22, 2010
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DUAL USE RESEARCH-October 22, 2009
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Gain-of-Function Research on Highly Pathogenic Avian Influenza H5N1 Viruses:
An International Consultative Workshop
December 17-18, 2012
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The U.S. Department of Health and Human Services (HHS) sponsored an international consultative workshop on December 17-18, 2012 on
Gain-of-Function Research on Highly Pathogenic Avian Influenza H5N1 Viruses.
The purpose of this workshop was to provide a forum for sharing multidisciplinary international perspectives on research that aims to increase transmissibility, increase pathogenicity, and/or alter host range of highly pathogenic avian influenza (HPAI) H5N1 viruses. Specific issues for discussion included the implications of such research for global public health; risks and concerns associated with this research; the risks of not conducting such research; fundamental principles regarding the conduct and oversight of such research; and conditions under which such research might be conducted. Perspectives were presented by individuals from around the globe who collectively have a broad range of expertise in such areas as influenza, other infectious diseases, dual use research, bioethics, national and global public health, biosecurity, epidemiology, national security, public health surveillance, biosafety, biosecurity agriculture/veterinary sciences, the WHO International Health Regulations and the Pandemic Influenza Preparedness Framework, global public health law, and medical countermeasure development. In addition, participants had the opportunity to exercise a proposed HHS funding framework through discussion of a series of case studies.
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The slides presented in opening the meeting, as well as those prepared by session co-chairs after each panel to summarize the discussions, are available by accessing the final agenda for the event and subsequently clicking on the appropriate hyperlinked text.
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The comment period on the proposed HHS funding framework closed January 10, 2013.
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THE INTERSECTION OF SCIENCE AND SECURITY: A CASE STUDY APPROACH
CONTINUING THE GLOBAL DIALOGUE WITH THE SCIENTIFIC AND SCIENCE POLICY COMMUNITY:
FOCUS ON ASIA AND THE WESTERN PACIFIC
ARCHIVED WORKSHOP VIDEO
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BACKGROUND:
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On December 9, 2011 the United States Government sponsored a workshop,
The Intersection of Science and Security: a Case Study Approach, Continuing the global dialogue with the scientific and science policy community: focus on Asia and the Western Pacific
. The purpose of this workshop was to give attendees a greater understanding of dual use research, including an awareness of strategies for managing dual use research of concern and an appreciation of how these issues are being addressed around the globe. The workshop utilized published articles as case studies, involving Mousepox and a SARS-like virus, as examples of dual use research of concern that highlight issues which investigators, institutions, journal editors, governments, and the scientific and security policy communities need to consider. In addition to presentations of the case studies, there were discussions among all panelists and attendees on global science and security issues as well as those of special interest within Asia and the Western Pacific, including information on training and education resources currently available.
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Agenda, Meeting Materials and Participant Biographies
Workshop Video
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RESPONSIBLE CONDUCT OF RESEARCH SESSION
Organized by AAAS and the Kuwait Institute of Scientific Research (KISR) in collaboration with NIH/NSABB
SUMMARY OF VIDEO-TELECONFERENCE
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BACKGROUND:
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On March 16, 2011 NIH, NSABB, the American Association for the Advancement of Sciences (AAAS) and the Kuwait Institute for Scientific Research conducted a bilateral video-teleconference (VTC) on the topic of Responsible Conduct of Research (RCR). This two-hour plenary RCR session was part of the AAAS International Engagement Meeting: Responsible Bioscience for a Safe and Secure Society. The purpose of the session was to engage life scientists and policy makers from the Broader Middle East and North Africa region (BMENA) on the issue of RCR. For this conference, RCR included three sub-topics: biosafety, bioethics, and biosecurity/DUR. Three panelists, including Dr. Michael Imperiale (NSABB), gave presentations on the sub-topics. The session continued with a general discussion on the three RCR sub-topics among participants in Kuwait and a Washington-based panel, which included Drs. Paul Keim (NSABB), Stuart Levy (NSABB), and Kavita Berger (AAAS).
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SUMMARY |
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STRENGTHENING THE CULTURE OF RESPONSIBILITY WITH RESPECT TO DUAL USE RESEARCH AND BIOSECURITY
ARCHIVED VIDEO-TELECONFERENCE
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BACKGROUND: |
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On November 1, 2010 the National Institutes of Health (NIH) National Science Advisory Board for Biosecurity (NSABB) and the Chinese
Academy of Sciences organized a bilateral video-teleconference (VTC) entitled
Strengthening the Culture of Responsibility with
Respect to Dual Use Research and Biosecurity.
This event was a satellite session of the international workshop
Trends
in Science and Technology Relevant to the Biological and Toxin Weapons Convention
in Beijing, China. The VTC was held in cooperation with the InterAcademy Panel:
The Global Network of Science Academies, the International Union of Microbiological Societies, the International Union of Biochemistry and Molecular Biology,
and the National Research Council of the U.S. National Academy of Sciences.
The aim of the VTC was to raise awareness of the dual use issue among workshop participants, to engage participants in a discussion on fostering
a culture of responsibility, and to inform the NSABB on the views of these international scientists and policy experts from over 30 countries.
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The one-hour VTC linked participants at the workshop site in Beijing with key experts in Bethesda, MD. Issues discussed included
the principal features or attributes of a culture of responsibility and strategies for promoting, creating, and sustaining a culture
of responsibility. The archived version of the VTC is available at:
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Videocast |
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PROGRAM:
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Welcome and Introductions |
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NIH/NSABB and Chinese Academy of Sciences: |
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Dr. Patterson and Dr. Li Huang |
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Principal features or attributes of a culture of responsibility and Strategies for promoting, creating, and sustaining a culture of responsibility |
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Remarks to Stimulate Responses to Questions and Discussion: |
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Dr. Paul Keim, Co-chair, NSABB Culture of Responsibility Working Group |
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Questions for conference participants |
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Co-Moderators: NSABB: Dr. David Franz, CAS: Dr. Li Huang |
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1. The NSABB has been tasked with developing guidance on how to enhance the culture of responsibility with regard to biosecurity concerns
in general and in high containment laboratories. What are the attributes of a strong culture of responsibility in this regard? |
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2. What are some of the ways that Principal Investigators/lab leaders can strengthen a culture of responsibility regarding biosecurity? |
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3. How can the senior leaders of research institutions help to foster a culture of responsibility regarding biosecurity? |
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4. What are effective ways to educate scientists about the importance of biosecurity? For example, should it be tied in with education about biosafety? |
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5. Do you think codes of conduct are a useful tool for strengthening the culture of responsibility and raising awareness about dual use research and biosecurity issues?
What is the best way to encourage acceptance of and adherence to a code of conduct in a research organization? |
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Closing Remarks |
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NIH: Dr. Amy Patterson and CAS: Dr. Li Huang |
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PANELISTS/MODERATORS: |
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BEIJING |
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David Franz, D.V.M., Ph.D.BIO |
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Vice President and Chief Biological Scientist, Midwest Research Institute, Frederick, MD, USA |
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Li Huang, Ph.D.BIO |
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Director, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China |
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BETHESDA |
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Susan Ehrlich, J.D., LL.M.BIO |
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Judge (Retired), Arizona Court of Appeals, Phoenix, AZ, USA |
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Paul Keim, Ph.D. BIO |
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Division Director, Pathogen Genomics Translational Genomics Research Institute |
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Cowden Endowed Chair in Microbiology, Northern Arizona University, Flagstaff, AZ, USA |
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Stuart Levy, M.D.BIO |
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Director, Center for Adaptation Genetics and Drug Resistance, Professor of Molecular Biology |
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Microbiology and Medicine, Tufts University School of Medicine, Boston, Mass, USA |
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Amy P. Patterson, M.D.BIO |
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Associate Director for Science Policy |
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National Institutes of Health, Bethesda, MD, USA |
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DOES YOUR RESEARCH RAISE SECURITY CONCERNS? STRATEGIES FOR PROMOTING RESPONSIBLE RESEARCH IN THE LIFE SCIENCES
ARCHIVED WEBCAST |
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Background:
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On September 22, 2010, the U.S. government hosted the second in a series of Internet-based meetings aimed at engaging the international
community by region. The focus of this event was Europe. It was hosted by the National Science Advisory Board for Biosecurity (NSABB) in
partnership with the European Molecular Biology Organization, the European Science Foundation, the European Society of Clinical Microbiology
and Infectious Diseases, and Institut Pasteur. This webcast included both presentations and discussions by European and U.S. scientists on
dual use research with a special focus on antimicrobial resistance and synthetic biology. Participants also examined various approaches
to promoting the responsible conduct of research with dual use potential. The event was interactive, with panelists responding to questions submitted by viewers.
View Full Archived Webcast
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AGENDA: A detailed program can be found here.
The slides for each presentation are hyperlinked from the title.
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8:00 AM Welcome and Opening Remarks |
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Amy P. Patterson, M.D.
National Institutes of Health
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Andrzej Gorski, M.D., Ph.D
Polish Academy of Sciences
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8:10 AM SESSION I
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Moderators: |
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Andrzej Gorski, M.D., Ph.D
Polish Academy of Sciences
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David R. Franz, D.V.M., Ph.D
Midwest Research Institute
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What are "DUR" and "DURC"
David R. Franz, D.V.M., Ph.D
Midwest Research Institute
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Antimicrobial Resistance and Dual Use
Stuart B. Levy, M.D.
Tufts University School of Medicine
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Synthetic Biology and Dual Use
Oscar P. Kuipers, Ph.D.
University of Groningen
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Marcus Schmidt, Ph.D.
Organization for International Dialogue and Conflict Management
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Commentary
David A. Relman, M.D.
Stanford University School of Medicine
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Panelists Introductions |
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8:40 AM Panel Discussion
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9:15 AM SESSION II
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Moderators: |
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Mihail Kritkos, Ph.D.
European Commission
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Stuart B, Levy, M.D.
Tufts School of Medicine
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European Activities
Andrzej Gorski, M.D., Ph.D
Polish Academy of Sciences
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Recommendations of the NSABB
David R. Franz, D.V.M., Ph.D
Midwest Research Institute
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9:35 AM Panel Discussion
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9:50 AM SESSION III
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Moderators: |
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Marcus Schmidt, Ph.D.
Organization for International Dialogue and Conflict Management
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David A. Relman, M.D.
Stanford University School of Medicine
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Panel Discussion |
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10:25 AM Concluding Remarks
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Stuart B. Levy, M.D.
Tufts University School of Medicine
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David R. Franz, D.V.M., Ph.D
Midwest Research Institute
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Gerald Parker, D.V.M., M.S.
Department of Health and Human Services
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Andrzej Gorski, M.D., Ph.D
Polish Academy of Sciences
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10:30 AM Adjourn
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Panelists:
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David R. Franz, D.V.M., Ph.D.
Vice President and Chief Biological Scientist
Midwest Research Institute
Frederick, MD, USA
Andrzej Gorski, M.D.,Ph.D.
Vice President, Polish Academy of Sciences
Chair, InterAcademy Panel Working Group on Biosecurity
Warsaw, Poland
Mihail Kritikos, Ph.D.
Research Programme Manager - Ethics Review
DG Research
European Commission
Brussels, Belgium
Professor Dr. Oscar P. Kuipers
Molecular Genetics Group
Groningen Biomolecular Sciences and Biotechnology Institute
University of Groningen
Groningen, The Netherlands
Stuart B. Levy, M.D.
Director, Center for Adaptation Genetics and Drug Resistance
Professor of Molecular Biology, Microbiology and Medicine
Tufts University School of Medicine
Boston, Massachusetts, USA
Linda Miller, Ph.D.
Associate Dean for Basic Sciences
New York University School of Medicine
(Former U.S. Executive Editor,
Nature and the Nature Journals)
New York, New York
USA
Gerald Parker, D.V.M., Ph.D., M.S.
Principal Deputy Assistant Secretary,
Office of the Assistant Secretary for Preparedness and Response
Department of Health and Human Services
Washington, DC, USA
Amy Patterson, M.D.
Acting Director, Office of Science Policy
Office of the Director
National Institutes of Health
Bethesda, Maryland, USA
David A. Relman, M.D.
Professor of Microbiology & Immunology
Professor of Medicine
Stanford University School of Medicine
Stanford, California, USA
Guenael R. Rodier, M.D.
Director, Communicable Diseases
Health Security, & Environment
World Health Organization,
Regional Office for Europe
Copenhagen, Denmark
Markus Schmidt, Ph.D.
Board Director/Biosafety
Co-founder
Organization for International Dialogue and Conflict Management
Vienna, Austria
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ARCHIVED VIDEOCAST |
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Background:
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On October 22, 2009, the United States National Institutes of Health (NIH) sponsored its first regional Webinar on dual use research, hosted by the US National Science Advisory Board for Biosecurity (NSABB). The goal of the event was to foster international engagement of life sciences researchers, biosafety and biosecurity experts, government policy officials, and ethicists on the issue of dual use life sciences research.
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Effective global dialogue on concerns and issues regarding dual use life sciences research is key to achieving an effective balance between public health priorities and national security concerns.
Numerous national- and international-level activities are currently underway to raise awareness of the risks posed by dual use life sciences research as well as to address or manage these risks while,
at the same time, promoting responsible life sciences research. This international Videocast focused on the Americas is the first in a series of internet-based meetings aimed at engaging the
international community by region. To learn more about dual use research visit: Dual Use Research.
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View Archived Videocast
View the archived Videocast in English
View the archived Videocast in Spanish
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Program
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Introduction and Background
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Presentations on Dual Use Research
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What is "dual use research" and "dual use research of concern"?
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How can risks associated with "dual use research of concern" be meaningfully assessed?
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What strategies for managing and/or addressing these risks have been proposed or implemented?
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What is being done to strengthen research governance in the Americas?
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Question and Answer/Comment Session
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Next Steps
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Panel Presenters
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Luis Gabriel Cuervo, M.D.,
Senior Advisor
Research Promotion and Development
Area of Technology Health Care & Research (THR/RP)
Pan American Health Organization (PAHO)
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David R. Franz, D.V.M., Ph.D.
Vice President and Chief Biological Scientist
Midwest Research Institute
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Dennis L. Kasper, M.D.
William Ellery Channing Professor of Medicine and Professor of Microbiology and Molecular Genetics Harvard Medical School;
Director, Channing Laboratory
Department of Medicine
Brigham and Women's Hospital
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Stuart B. Levy, M.D.
Director
Center for Adaptation Genetics & Drug Resistance
Professor of Molecular Biology, Microbiology and Medicine
School of Medicine
Tufts University
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Amy P. Patterson, M.D.
Acting Associate Director for Science Policy
Office of the Director
US National Institutes of Health
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Will I be able to view the Videocast?
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You need RealPlayer software and a broadband connection of 512K or faster to view the Videocast.
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You can download free RealPlayer . (For Macintosh click here: MacPlayer)
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Go to: Test Computer to see if your computer is ready.
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If you need help, call the NIH Help Desk at (301) 496-4357, toll free (866) 319-4357 or visit NIH IT Service Desk.
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