Roderic Pettigrew, Ph.D., M.D. Director 31 Center Drive Room 1C-14, MSC 2281 Bethesda, MD 20892-2281 Tel: 301-496-8859 Fax: 301-480-4973 E-mail: pettigrr@mail.nih.gov

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Roderic I. Pettigrew, Ph.D., M.D., is the first Director of the National Institute of Biomedical Imaging and Bioengineering at the NIH. Prior to his appointment at the NIH, he was Professor of Radiology, Medicine (Cardiology) at Emory University and Bioengineering at the Georgia Institute of Technology and Director of the Emory Center for MR Research, Emory University School of Medicine, Atlanta, Georgia.

Dr. Pettigrew is known for his pioneering work at Emory University involving four-dimensional imaging of the cardiovascular system using magnetic resonance (MRI). Dr. Pettigrew graduated cum laude from Morehouse College with a B.S. in Physics, where he was a Merrill Scholar; has an M.S. in Nuclear Science and Engineering from Rennselear Polytechnic Institute; and a Ph.D. in Applied Radiation Physics from the Massachusetts Institute of Technology, where he was a Whitaker Harvard-MIT Health Sciences Scholar. Subsequently, he received an M.D. from the University of Miami School of Medicine in an accelerated two-year program, did an internship and residency in internal medicine at Emory University and completed a residency in nuclear medicine at the University of California, San Diego. Dr. Pettigrew then spent a year as a clinical research scientist with Picker International, the first manufacturer of MRI equipment, where he helped develop their first cardiac imaging technology. In 1985, he joined Emory as a Robert Wood Johnson Foundation Fellow with an interest in non-invasive cardiac imaging. His current research focuses on integrated imaging and predictive biomechanical modeling of coronary atherosclerotic disease.

Dr. Pettigrew's awards include membership in Phi Beta Kappa, the Bennie Award (Benjamin E. Mays) for Achievement, and being named the Most Distinguished Alumnus of the University of Miami (1990). He was the Radiological Society of North America's 75th Diamond Jubilee Eugene P. Pendergrass New Horizons Lecturer. He is also the recipient of the Herbert Nickens Award of the ABC, the Pritzker Distinguished Achievement Award of the Biomedical Engineering Society, and the Distinguished Service Award of the National Medical Association. He has been elected to membership in two components of the US National Academies: the Institute of Medicine, and the National Academy of Engineering.

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 Scientific Publications

| 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999

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2011

Gharib AM, Abd-Elmoniem KZ, Pettigrew RI, Hadigan C. Noninvasive coronary imaging for atherosclerosis in human immunodeficiency virus infection. Curr Probl Diagn Radiol. 2011 Nov-Dec;40(6):262-7.

Gharib AM, Abd-Elmoniem KZ, Herzka DA, Ho VB, Locklin J, Tzatha E, Stuber M, Pettigrew RI. Optimization of coronary whole-heart MRA free-breathing technique at 3 Tesla. Magn Reson Imaging. 2011 Oct;29(8):1125-30. Epub 2011 Aug 25

Ohayon J, Gharib AM, Garcia A, Heroux J, Yazdani SK, Malvè M, Tracqui P, Martinez MA, Doblare M, Finet G, Pettigrew RI. Is arterial wall-strain stiffening an additional process responsible for atherosclerosis in coronary bifurcations?: an in vivo study based on dynamic CT and MRI. Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H1097-106. Epub 2011 Jun 17.

Mikhail IJ, Purdy JB, Dimock DS, Thomas VM, Muldoon NA, Clauss SB, Cross RR, Pettigrew RI, Hazra R, Hadigan C, Gharib AM. High rate of coronary artery abnormalities in adolescents and young adults infected with human immunodeficiency virus early in life. Pediatr Infect Dis J. 2011 Aug;30(8):710-2.

Freeman AF, Avila EM, Shaw PA, Davis J, Hsu AP, Welch P, Matta JR, Hadigan C, Pettigrew RI, Holland SM, Gharib AM. Coronary artery abnormalities in Hyper-IgE syndrome. J Clin Immunol. 2011 Jun;31(3):338-45. Epub 2011 Apr 15

Abd-Elmoniem KZ, Obele CC, Sibley CT, Matta JR, Pettigrew RI, Gharib AM. Free-breathing single navigator gated cine cardiac magnetic resonance at 3 T: feasibility study in patients. J Comput Assist Tomogr. 2011 May-Jun;35(3):382-6.

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2010

Oshinski JN, Delfino JG, Sharma P, Gharib AM, Pettigrew RI. Cardiovascular magnetic resonance at 3.0 T: current state of the art. J Cardiovasc Magn Reson. 2010 Oct 7;12:55. Review.

Le Floc'h S, Cloutier G, Finet G, Tracqui P, Pettigrew RI, Ohayon J. On the potential of a new IVUS elasticity modulus imaging approach for detecting vulnerable atherosclerotic coronary plaques: in vitro vessel phantom study. Phys Med Biol. 2010 Oct 7;55(19):5701-21. Epub 2010 Sep 8.

Heroux J, Gharib AM, Danthi NS, Cecchini S, Ohayon J, Pettigrew RI. High-affinity alphavbeta3 integrin targeted optical probe as a new imaging biomarker for early atherosclerosis: initial studies in Watanabe rabbits. Mol Imaging Biol. 2010 Jan-Feb;12(1):2-8.

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2009

Gharib AM, Pettigrew RI, Elagha A, Hsu A, Welch P, Holland SM, Freeman AF. Coronary abnormalities in hyper-IgE recurrent infection syndrome: depiction at coronary MDCT angiography. AJR Am J Roentgenol. 2009 Dec;193(6):W478-81.

Boudou T, Ohayon J, Picart C, Pettigrew RI, Tracqui P. Nonlinear elastic properties of polyacrylamide gels: implications for quantification of cellular forces. Biorheology. 2009;46(3):191-205.

Kotys MS, Herzka DA, Vonken EJ, Ohayon J, Heroux J, Gharib AM, Stuber M, Pettigrew RI. Profile order and time-dependent artifacts in contrast-enhanced coronary MR angiography at 3T: origin and prevention. Magn Reson Med. 2009 Aug;62(2):292-9.

Herzka DA, Kotys MS, Sinkus R, Pettigrew RI, Gharib AM. Magnetic resonance elastography in the liver at 3 Tesla using a second harmonic approach. Magn Reson Med. 2009 Aug;62(2):284-91.

Le Floc'h S, Ohayon J, Tracqui P, Finet G, Gharib AM, Maurice RL, Cloutier G, Pettigrew RI. Vulnerable atherosclerotic plaque elasticity reconstruction based on a segmentation-driven optimization procedure using strain measurements: theoretical framework. IEEE Trans Med Imaging. 2009 Jul;28(7):1126-37. Epub 2009 Jan 19.

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2008

Ohayon J, Finet G, Gharib AM, Herzka DA, Tracqui P, Heroux J, Rioufol G, Kotys MS, Elagha A, Pettigrew RI. Necrotic core thickness and positive arterial remodeling index: emergent biomechanical factors for evaluating the risk of plaque rupture. Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H717-27.

Gharib AM, Ho VB, Rosing DR, Herzka DA, Stuber M, Arai AE, Pettigrew RI. Coronary artery anomalies and variants: technical feasibility of assessment with coronary MR angiography at 3 T. Radiology. 2008 Apr;247(1):220-7.

Gharib AM, Elagha A, Pettigrew RI. Cardiac magnetic resonance at high field: promises and problems. Curr Probl Diagn Radiol. 2008 Mar-Apr;37(2):49-56.

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2007

Pettigrew RI, Peterson KP, Heetderks W, Seto B. The National Institute of Biomedical Imaging and Bioengineering marks its first five years. Acad Radiol. 2007 Dec;14(12):1448-54.

Gharib AM, Herzka DA, Ustun AO, Desai MY, Locklin J, Pettigrew RI, Stuber M. Coronary MR angiography at 3T during diastole and systole. J Magn Reson Imaging. 2007 Oct;26(4):921-6.

Ohayon J, Dubreuil O, Tracqui P, Le Floc'h S, Rioufol G, Chalabreysse L, Thivolet F, Pettigrew RI, Finet G. Influence of residual stress/strain on the biomechanical stability of vulnerable coronary plaques: potential impact for evaluating the risk of plaque rupture. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1987-96.

Greil GF, Desai MY, Fenchel M, Miller S, Pettigrew RI, Sieverding L, Stuber M. Reproducibility of free-breathing cardiovascular magnetic resonance coronary angiography. J Cardiovasc Magn Reson. 2007;9(1):49-56.

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2006

Pettigrew RI. Team science and the NIBIB. Science. 2006 Jun 30;312(5782):1873.

Alexander DF, Alving BM, Battey JF, Berg JM, Collins FS, Fauci AS, Gallin JI, Grady PA, Hodes RJ, Hrynkow SH, Insel TR, Jones JF, Katz SI, Landis SC, Li TK, Lindberg DA, Nabel EG, Niederhuber JE, Pettigrew RI, Rodgers GP, Ruffin J, Scarpa A, Schwartz DA, Sieving PA, Straus SE, Tabak LA, Volkow ND. Response to: "Rescuing the NIH before it is too late." J Clin Invest Apr 28, 2006.

Nezafat R, Stuber M, Ouwerkerk R, Gharib AM, Desai MY, Pettigrew RI. B1-insensitive T2 preparation for improved coronary magnetic resonance angiography at 3 T. Magn Reson Med 55(4):858-64, 2006.

Sharma P, Socolow J, Patel S, Pettigrew RI, Oshinski JN. Effect of Gd-DTPA-BMA on blood and myocardial T1 at 1.5T and 3T in humans. J Magn Reson Imaging 23(3):323-30, 2006.

2005

Seto DB, McLaughlin A, Li K, Menkens A, Sullivan D, Pettigrew R. Advancing the Boundaries of Molecular Imaging. Biol Psychiatry Sep 13, 2005.

Simor T, Gaszner B, Oshinski JN, Waldrop SM, Pettigrew RI, Horvath IG, Hild G, Elgavish GA. Gd(ABE-DTTA)-enhanced cardiac MRI for the diagnosis of ischemic events in the heart. J Magn Reson Imaging 21(5):536-45, 2005. 

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2004

Pettigrew RI, Fee CA, Li KC. Changes in the world of biomedical research are moving the field of "personalized medicine" from concept to reality. J Nucl Med 45(9):1427, 2004.

Johnson KR, Patel SJ, Whigham A, Hakim A, Pettigrew RI, Oshinski JN. Three-dimensional, time-resolved motion of the coronary arteries. J Cardiovasc Magn Reson 6(3):663-73, 2004. 

Muthupillai R, Flamm SD, Wilson JM, Pettigrew RI, Dixon WT. Acute myocardial infarction: tissue characterization with T1rho-weighted MR imaging--initial experience. Radiology 232(2):606-10, 2004. 

Brummer ME, Moratal-Perez D, Hong CY, Pettigrew RI, Millet-Roig J, Dixon WT. Noquist: reduced field-of-view imaging by direct Fourier inversion. Magn Reson Med 51(2):331-42, 2004.

2003

Fee CA, Pettigrew RI. National Institute of Biomedical Imaging and Bioengineering: poised for the future. Radiology 229(3):636-7, 2003.

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2002

Han HC, Oshinski JN, Ku DN, Pettigrew RI. A left ventricle model to predict post-revascularization ejection fraction based on cine magnetic resonance images. J Biomech Eng 124(1):52-5, 2002.

2001

Faber TL, Vansant JP, Pettigrew RI, Galt JR, Blais M, Chatzimavroudis G, Cooke CD, Folks RD, Waldrop SM, Gurtler-Krawczynska E, Wittry MD, Garcia EV. Evaluation of left ventricular endocardial volumes and ejection fractions computed from gated perfusion SPECT with magnetic resonance imaging: comparison of two methods. J Nucl Cardiol 8(6):645-51, 2001.

Oshinski JN, Han HC, Ku DN, Pettigrew RI. Quantitative prediction of improvement in cardiac function after revascularization with MR imaging and modeling: initial results. Radiology 221(2):515-22, 2001.

Chatzimavroudis GP, Oshinski JN, Franch RH, Walker PG, Yoganathan AP, Pettigrew RI. Evaluation of the precision of magnetic resonance phase velocity mapping for blood flow measurements. J Cardiovasc Magn Reson 3(1):11-9, 2001.

Videlefsky N, Parks WJ, Oshinski J, Hopkins KL, Sullivan KM, Pettigrew RI, Fyfe D. Magnetic resonance phase-shift velocity mapping in pediatric patients with pulmonary venous obstruction. J Am Coll Cardiol 38(1):262-7, 2001.

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2000

Ensley AE, Ramuzat A, Healy TM, Chatzimavroudis GP, Lucas C, Sharma S, Pettigrew R, Yoganathan AP. Fluid mechanic assessment of the total cavopulmonary connection using magnetic resonance phase velocity mapping and digital particle image velocimetry. Ann Biomed Eng 28(10):1172-83, 2000.

Laham RJ, Chronos NA, Pike M, Leimbach ME, Udelson JE, Pearlman JD, Pettigrew RI, Whitehouse MJ, Yoshizawa C, Simons M. Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemic heart disease: results of a phase I open-label dose escalation study. J Am Coll Cardiol 36(7):2132-9, 2000.

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1999

Faber TL, Cooke CD, Folks RD, Vansant JP, Nichols KJ, DePuey EG, Pettigrew RI, Garcia EV. Left ventricular function and perfusion from gated SPECT perfusion images: an integrated method. J Nucl Med 40(4):650-9, 1999.

Oshinski JN, Franch R, Shirazi SH, Pettigrew RI. Use of navigator-echo-gated MRI to diagnose a coronary shunt involving an anomalous origin of the right coronary artery from the pulmonary artery. J Magn Reson Imaging 9(5):738-40, 1999.

Bom HS, Vansant JP, Pettigrew RI, Cooke CD, Votaw JR, Garcia EV. Determination of Myocardial Viability with ECG-Gated Fluorodeoxyglucose F-18 Positron Emission Tomography. Clin Positron Imaging. 2(4):183-190, 1999.

Pettigrew RI, Oshinski JN, Chatzimavroudis G, Dixon WT. MRI techniques for cardiovascular imaging. J Magn Reson Imaging 10(5):590-601, 1999.

Alazraki NP, Krawczynska EG, Kosinski AS, DePuey EG 3rd, Ziffer JA, Taylor AT Jr, Pettigrew RI, Vansant JP, Shaw LJ, Weintraub WS, King SB 3rd. Prognostic value of thallium-201 single-photon emission computed tomography for patients with multivessel coronary artery disease after revascularization (the Emory Angioplasty versus Surgery Trial [EAST]). Am J Cardiol 84(12):1369-74, 1999.

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