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Title: Meta-analyses of dietary fats and mammary neoplasms in rodent experiments.
Authors: Fay MP,  Freedman LS
Journal: Breast Cancer Res Treat
Date: 1997 Nov-Dec
PubMed ID: 9478276
PMC ID: not available
Abstract: We review two meta-analyses of experiments on dietary fat and mammary tumor incidence in rodents, emphasizing a recent meta-analysis on the effects of different types of dietary fatty acids. This analysis shows that n-6 polyunsaturated fatty acids most strongly enhance mammary tumors in rodents, and saturated fats also enhance these tumors but less strongly. Further, the analysis shows that energy restriction protects against mammary tumors. We show that these results agree qualitatively with estimates of effects on human breast cancer derived from international correlations.