Oral Manifestations of Aplastic Anemia
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Purpose
The purposes of this study are threefold: 1) to evaluate the prevalence and risks of oral complications in patients with aplastic anemia; 2) to evaluate if oral problems in these patients can predict their response to treatment; and 3) to review complications of dental treatment in these patients in order to establish treatment guidelines.
This study will be performed through a review of medical charts of 79 patients with aplastic anemia and 67 patients with schizophrenia who were treated at the National Institutes of Health Dental Clinic between 1993 and 1999. The schizophrenia patients will serve as a control population.
Demographic, clinical and radiographic information will be collected for all patients. Additional data collected only for aplastic anemia patients will include medical therapy, disease duration, blood cell counts, oral problems that developed during treatment and treatment response.
| Condition |
|---|
|
Aplastic Anemia |
| Study Type: | Observational |
| Official Title: | Oral Manifestations of Aplastic Anemia |
| Estimated Enrollment: | 146 |
| Study Start Date: | April 2000 |
| Estimated Study Completion Date: | April 2002 |
The prevalence, risk factors and significance of oral manifestations in aplastic anemia have not been well characterized. Thus, in the present study, through a retrospective chart review, we document the prevalence of oral complications in AA patients and the risks for oral manifestations in a case-control study. Schizophrenic patients represent controls. Information includes the following; demographic, clinical and radiographic information for cases and controls. Additional data collection for only AA patients includes prior medical therapy, CBC and differential, disease duration, new oral manifestations during AA treatment and medical treatment response. We determine if systemic clinical features of AA predict oral manifestations, and if oral manifestations predict treatment outcomes for AA patients. Finally complications following dental treatment are compiled and reviewed to establish initial treatment guidelines for these patients.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
INCLUSION CRITERIA:
Cases: All aplastic anemia patients evaluated at the NIH dental clinic for consultation between 1993-1999.
Controls: All schizophrenic patients evaluated at the NIH dental clinic for consultation between 1993-1999.
EXCLUSION CRITERIA:
Patients without the diagnosis of aplastic anemia for cases or schizophrenia for the controls.
Contacts and Locations More Information
Publications:
| ClinicalTrials.gov Identifier: | NCT00006300 History of Changes |
| Other Study ID Numbers: | 000113, 00-D-0113 |
| Study First Received: | September 27, 2000 |
| Last Updated: | March 3, 2008 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Institutes of Health Clinical Center (CC):
|
Immunosuppression Treatment Recommendations Pancytopenia Schizophrenia Inpatient Population |
Additional relevant MeSH terms:
|
Anemia Anemia, Aplastic Oral Manifestations Hematologic Diseases |
Bone Marrow Diseases Mouth Diseases Stomatognathic Diseases Signs and Symptoms |
ClinicalTrials.gov processed this record on February 21, 2013
