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Bridging Interventional Development Gaps

  A technician in an NCATS chemistry laboratory advancing a chemical probe through analog synthesis.

Bridging Interventional Development Gaps (BrIDGs), previously the NIH Rapid Access to Intervention Development (RAID) program, was launched under its new name in October 2011. Led by the NCATS Division of Pre-Clinical Innovation, BrIDGs makes available, on a competitive basis, certain critical resources needed for the development of new therapeutic agents. Investigators do not receive grant funds through this program. Instead, successful applicants receive access to NIH contractors who conduct preclinical studies at no cost to the investigator. In general, synthesis, formulation, pharmacokinetic and toxicology services in support of investigator-held investigational new drug (IND) applications to the U.S. Food and Drug Administration (FDA) are available.

Contract costs are supported by the NIH Common Fund and collaborating NIH Institutes and Centers. Access to contracts is based on a peer-reviewed application process. The number of awards made will depend on the number of applications received, their scientific merit, and the availability of NIH funds.

As of November 2012, BrIDGs has generated data to support 12 INDs that have been cleared by the FDA and one clinical trial application that has been cleared by Health Canada. Twelve projects have been evaluated in clinical trials. Three BrIDGs-supported agents have gone as far as Phase II human clinical trials, in which researchers give an experimental therapy to a group of patients to evaluate the effectiveness and safety of a treatment. Third-party investors have licensed six agents during or after their development by BrIDGs.


BrIDGs Information

BrIDGs News

In December, NIH awarded several new projects via the BrIDGs program and announced that the program will be accepting new applications between December 1, 2012, and February 1, 2013. Learn more on the Apply to BrIDGs page.