BrIDGs Application Scoring Matrix
Submitted research applications will be reviewed for scientific merit and technical feasibility. The following scoring matrix will be used by reviewers to evaluate scientific merit. Although it is not a scored criterion, reviewers will also consider the quality of the intellectual property related to the proposed agent.
Score 1-3 High Score | Score 4-6 Average Score | Score 7-9 Poor Score | |
---|---|---|---|
Strength of Current Data Package (40%) | High quality in the relevant areas:
| High quality in some of the relevant areas and medium quality in other relevant areas:
| Medium or marginal quality in the relevant areas
|
Target and Therapeutic Validation (30%) | Target has been validated in animal pharmacology studies as well as in humans, and there is a link to therapeutic indication. | Target has been validated primarily in animal pharmacology or knock-out mouse studies. | Target has been validated in primarily in vitro in animals and/or humans. |
Feasibility to Reach First in Human (20%) | Have most of the following:
| Have many of the following:
| Have few to none of the following:
|
Medical Impact Relative to Current Standard of Care (10%) | There is no current treatment for the disease or clinical outcome. Or the current standard of care has considerable disadvantages or very limited utility | The current standard of care has potential disadvantages (resistance). Or the current standard of care has somewhat limited utility | The current standard of care is adequate, but additional treatments are desired. |
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