PQC - 2 How can the physical properties of tumors, such as a cell’s electrical, optical or mechanical properties, be used to provide earlier or more reliable cancer detection, diagnosis, prognosis, or monitoring of drug response or tumor recurrence? Background: There continue to be major advances in method development for the characterization of the physical properties of tumors. These physical features include, but are not limited to, the optical, electrical, and mechanical properties of tumor cells. Some studies have suggested that these properties may be easier to detect than other properties such as histological staining or other commonly used diagnostic methods. This Provocative Question seeks studies that expand on the physical characterization of tumors in different stages of development and asks that these physical features be correlated with appropriate diagnostic tests. Feasibility: Applications for this question will link advances in measurement of the physical properties of tumors with important clinical properties of tumors. Useful applications could include such subjects as advances in diagnostic techniques or the ability to distinguish specific stages of tumor development. Studies could be done in mouse models or on well-annotated human tumor samples. Implications of success: Advances in tumor diagnostics continue to be a major need in our characterization of tumors. |
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