Successful clinical trial accrual begins at the protocol writing stage. The earlier in the trial's lifecycle that you plan for accrual, the more likely the trial is to recruit enough participants to answer its scientific questions. Many clinical trials close without accruing a single participant.
Beyond the scientific merit of a proposed clinical trial, protocol developers should think carefully about how the field as well as potential participants might receive the trial.
In developing a protocol, consider competing trials, the availability of the study population, and ways to reduce the study burden on sites and participants.