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Molecular Libraries Probe Production Center

The NIH Chemical Genomics Center (NCGC) is one of the centers in the Molecular Libraries Probe Production Centers Network (MLPCN), which is an NIH Common Fund Initiative. Through this program, biomedical researchers gain access to the large-scale small molecule screening capacity, along with medicinal chemistry and informatics necessary to identify chemical probes to study the functions of genes, cells and biochemical pathways. These chemical probes may also be used in developing of new drugs.

MLPCN activities at NCGC are conducted in the Probe Development Branch of the NCATS Division of Pre-Clinical Innovation. The scientists in this branch conduct research in high-throughput assay development and screening, informatics and modeling, and analytical and medicinal chemistry. All Molecular Libraries Probe Production Center Projects are highly collaborative and interactive.

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Activating Key Cancer Enzyme Blocks Tumor Growth in Mice

A team that includes nine NCATS researchers has identified compounds that delay tumor formation in mice. The compounds target a specific form of pyruvate kinase, called PKM2, which governs how cancer cells use glucose.