Depression

Depression is a medical condition that affects about 1 in 10 U.S. adults. Mood, thoughts, physical health, and behavior all may be affected. The symptoms and severity of depression can vary from person to person. Depression can be treated with conventional medicine, including antidepressants and certain types of psychotherapy. For more information on depression, visit the National Institute of Mental Health's Web site.

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St. John's Wort and Depression

St. John’s wort has been studied for depression. This fact sheet summarizes research on St. John’s wort for depression, provides information on safety and side effects, and suggests sources for more information. From the U.S. government’s National Institutes of Health.

For Consumers

General Information

Research Spotlights

Omega-3 Fatty Acids May Reduce Inflammation and Anxiety in Healthy Young Adults
(07/19/11)
A Review of St. John's Wort Extracts for Major Depression
(10/08/08)
Omega-3 fatty acids may be helpful in psychiatric care
(12/01/06)
Polyunsaturated Fatty Acids for Depression
(05/01/06)
Study Shows St. John's Wort Ineffective for Major Depression of Moderate Severity
(04/10/02)

For Health Professionals

NCCAM Clinical Digest

Clinical Digest: Stress and Relaxation Techniques
Clinical Digest: St. John’s Wort and Depression
Clinical Digest: Depression and Complementary Health Practices

Scientific Literature

Systematic Reviews/Reviews/Meta-analysis (PubMed®)
Randomized Controlled Trials (PubMed®)