]> 4.03 CTCAE Is_Grade R1 DEFINITION P2 FULL_SYN P3 MedDRA_Code P4 NCIt_Code P5 Preferred_Name P1 AHC0 true Abdominal distension 10000060 NCIA disorder characterized by swelling of the abdomen. Abdomen enlarged feeling ofLLTMedDRA10000046 Abdomen enlargedLLTMedDRA10000045 Abdominal bloatingLLTMedDRA10048746 Abdominal distension gaseousLLTMedDRA10000061 Abdominal distensionLLTMedDRA10000060 Abdominal distensionPTCTCAE Abdominal fullnessLLTMedDRA10000065 Bloated feeling generalLLTMedDRA10050472 Bloated feelingLLTMedDRA10005264 Bloating NOSLLTMedDRA10005267 BloatingLLTMedDRA10005265 Distended abdomenLLTMedDRA10013480 Distension NOSLLTMedDRA10013481 DistentionLLTMedDRA10013482 Enlargement abdomenLLTMedDRA10014842 Epigastric fullnessLLTMedDRA10015018 Feeling of fullness in abdomenLLTMedDRA10016348 Feeling of gastrointestinal fullnessLLTMedDRA10016349 Fullness abdominalLLTMedDRA10017467 Gastrointestinal fullnessLLTMedDRA10017953 Stomach fullnessLLTMedDRA10042106 Swelling abdLLTMedDRA10042678 Swelling abdomenLLTMedDRA10042679 Swollen abdomenLLTMedDRA10042714 Abdominal distension C78161 E10456 Abdominal infection 10056519 NCIA disorder characterized by an infectious process involving the abdominal cavity. Abdominal infectionLLTMedDRA10056519 Abdominal infectionPTCTCAE Intra-abdominal infectionLLTMedDRA10056570 Abdominal infection C35669 E11282 Abdominal pain 10000081 NCIA disorder characterized by a sensation of marked discomfort in the abdominal region. Abdominal colicLLTMedDRA10000055 Abdominal crampLLTMedDRA10000056 Abdominal crampsLLTMedDRA10000057 Abdominal crampy painsLLTMedDRA10000058 Abdominal pain NOSLLTMedDRA10000085 Abdominal pain aggravatedLLTMedDRA10048358 Abdominal pain generalisedLLTMedDRA10000082 Abdominal pain generalizedLLTMedDRA10058826 Abdominal pain localisedLLTMedDRA10000083 Abdominal pain localizedLLTMedDRA10062367 Abdominal painLLTMedDRA10000081 Abdominal painPTCTCAE Central abdominal painLLTMedDRA10007927 Chronic abdominal painLLTMedDRA10066568 Colic abdominalLLTMedDRA10009882 ColicLLTMedDRA10009881 ColickyLLTMedDRA10009886 Cramp abdominalLLTMedDRA10011286 Duodenal ulcer-type symptomsLLTMedDRA10013860 Functional abdominal painLLTMedDRA10064907 Griping abdomenLLTMedDRA10018726 Griping abdominalLLTMedDRA10018727 Pain abdominalLLTMedDRA10033374 Peritoneal painLLTMedDRA10065801 Periumbilical painLLTMedDRA10054850 Postprandial painLLTMedDRA10065606 Premenstrual crampsLLTMedDRA10065309 Spleen painLLTMedDRA10050997 Abdominal pain C26682 E10460 Abdominal soft tissue necrosis 10065775 NCIA disorder characterized by a necrotic process occurring in the soft tissues of the abdominal wall. Abdominal soft tissue necrosisLLTMedDRA10065775 Abdominal soft tissue necrosisPTCTCAE Head soft tissue necrosisLLTMedDRA10065779 Neck soft tissue necrosisLLTMedDRA10065781 Pelvic soft tissue necrosisLLTMedDRA10065793 Soft tissue necrosis lower limbLLTMedDRA10065777 Soft tissue necrosis upper limbLLTMedDRA10065778 Soft tissue necrosisLLTMedDRA10065769 Abdominal soft tissue necrosis C78165 E12369 Abducens nerve disorder 10053662 NCIA disorder characterized by involvement of the abducens nerve (sixth cranial nerve). Abducens nerve disorderLLTMedDRA10053662 Abducens nerve disorderPTCTCAE VIth nerve disorderLLTMedDRA10053646 Abducens nerve disorder C27593 E12569 Accessory nerve disorder 10060929 NCIA disorder characterized by involvement of the accessory nerve (eleventh cranial nerve). Accessory nerve disorder NOSLLTMedDRA10000365 Accessory nerve disorderLLTMedDRA10060929 Accessory nerve disorderPTCTCAE Accessory nerve disorder C26953 E12573 Acidosis 10000486 NCIA disorder characterized by abnormally high acidity (high hydrogen-ion concentration) of the blood and other body tissues. AcidaemiaLLTMedDRA10060699 AcidemiaLLTMedDRA10060694 Acidosis NOSLLTMedDRA10000493 Acidosis aggravatedLLTMedDRA10066538 AcidosisLLTMedDRA10000486 AcidosisPTCTCAE Acute acidosisLLTMedDRA10066541 Chronic acidosisLLTMedDRA10066569 Acidosis C28228 E12237 Acoustic nerve disorder NOS 10000521 NCIA disorder characterized by involvement of the acoustic nerve (eighth cranial nerve). Acoustic nerve disorder NOSLLTMedDRA10000521 Acoustic nerve disorder NOSPTCTCAE Eighth cranial nerve lesionLLTMedDRA10014320 Eighth nerve lesion NOSLLTMedDRA10014322 Eighth nerve lesionLLTMedDRA10014321 VIIIth nerve lesion NOSLLTMedDRA10047410 VIIIth nerve lesionLLTMedDRA10062177 Acoustic nerve disorder NOS C27207 E12577 Activated partial thromboplastin time prolonged 10000636 NCIAn abnormal laboratory test result in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment. APTT increasedLLTMedDRA10003066 APTT prolongedLLTMedDRA10003067 Activated partial thromboplastin time increasedLLTMedDRA10000634 Activated partial thromboplastin time prolongedLLTMedDRA10000636 Activated partial thromboplastin time prolongedPTCTCAE PTT prolongedLLTMedDRA10037276 Partial thromboplastin time prolongedLLTMedDRA10034094 Activated partial thromboplastin time prolonged C27028 E12073 Acute coronary syndrome 10051592 NCIA disorder characterized by signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction. Acute coronary syndromeLLTMedDRA10051592 Acute coronary syndromePTCTCAE Attack coronaryLLTMedDRA10003723 Acute coronary syndrome C53652 E10066 Acute kidney injury 10069339 NCIA disorder characterized by the acute loss of renal function and is traditionally classified as pre-renal (low blood flow into kidney), renal (kidney damage) and post-renal causes (ureteral or bladder outflow obstruction). Acute kidney failureLLTMedDRA10000821 Acute kidney injuryLLTMedDRA10069339 Acute kidney injuryPTCTCAE Acute oliguric renal failureLLTMedDRA10068736 Acute on chronic renal failureLLTMedDRA10000952 Acute renal failure with lesion of tubular necrosisLLTMedDRA10001049 Acute renal failure, unspecifiedLLTMedDRA10001051 Acute renal failureLLTMedDRA10001041 Acute renal insufficiencyLLTMedDRA10050440 Failure kidney acuteLLTMedDRA10016150 Kidney failure acuteLLTMedDRA10023419 Renal failure acute hypotensiveLLTMedDRA10038437 Renal failure acute ischaemicLLTMedDRA10038438 Renal failure acute ischemicLLTMedDRA10038439 Renal failure acute on chronicLLTMedDRA10038440 Renal failure acute uraticLLTMedDRA10038441 Renal failure acuteLLTMedDRA10038436 Renal shutdown acuteLLTMedDRA10038526 Rhabdomyolysis-induced renal failureLLTMedDRA10050996 Shutdown renalLLTMedDRA10040622 Acute kidney injury C26808 E12973 Adrenal insufficiency 10001367 NCIA disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency. Adrenal cortex hypofunctionLLTMedDRA10001334 Adrenal cortex insufficiencyLLTMedDRA10001335 Adrenal cortical hypofunctionLLTMedDRA10001342 Adrenal cortical insufficiencyLLTMedDRA10001344 Adrenal hypofunctionLLTMedDRA10001366 Adrenal insufficiency NOSLLTMedDRA10001369 Adrenal insufficiencyLLTMedDRA10001367 Adrenal insufficiencyPTCTCAE Corticoadrenal insufficiencyLLTMedDRA10011172 HypoadrenalismLLTMedDRA10020936 HypoadrenocorticismLLTMedDRA10056485 Hypofunction adrenalLLTMedDRA10020979 Insufficiency adrenal cortexLLTMedDRA10022461 Insufficiency adrenalLLTMedDRA10022460 Adrenal insufficiency C26691 E10298 Adult respiratory distress syndrome 10001409 NCIA disorder characterized by progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. A.R.D.S.LLTMedDRA10000036 ARDSLLTMedDRA10003083 Acute respiratory distress syndromeLLTMedDRA10001052 Adult RDSLLTMedDRA10001407 Adult respiratory distress syndromeLLTMedDRA10001409 Adult respiratory distress syndromePTCTCAE Adult respiratory stress syndromeLLTMedDRA10001410 Respiratory distress syndrome adultLLTMedDRA10038691 Shock lungLLTMedDRA10040579 Surfactant deficiency syndrome adultLLTMedDRA10042607 Syndrome adult respiratory distressLLTMedDRA10042787 Syndrome respiratory distress adultLLTMedDRA10042839 Adult respiratory distress syndrome C3353 E13299 Adverse Event Severity Grade Adverse Event Severity GradePTCTCAE Adverse Event Severity Grade E10003 Adverse Event by System Organ Class Adverse Event by System Organ ClassPTCTCAE Adverse Event by System Organ Class E10002 Agitation 10001497 NCIA disorder characterized by a state of restlessness associated with unpleasant feelings of irritability and tension. AgitatedLLTMedDRA10001495 Agitation aggravatedLLTMedDRA10001498 Agitation mentalLLTMedDRA10001499 AgitationLLTMedDRA10001497 AgitationPTCTCAE Awaking excitabilityLLTMedDRA10003868 ExcitabilityLLTMedDRA10015622 ExcitableLLTMedDRA10015623 Excitement abnormalLLTMedDRA10015628 Excitement excessiveLLTMedDRA10015629 ExcitementLLTMedDRA10015627 FrenzyLLTMedDRA10017362 Hyperexcitability extremeLLTMedDRA10020626 HyperexcitabilityLLTMedDRA10020625 HyperexcitationLLTMedDRA10020627 Increased agitationLLTMedDRA10021651 Nocturnal agitationLLTMedDRA10049110 Agitation C79530 E12874 Akathisia 10001540 NCIA disorder characterized by an uncomfortable feeling of inner restlessness and inability to stay still; this is a side effect of some psychotropic drugs. AcathesiaLLTMedDRA10000355 AcathisiaLLTMedDRA10061244 Akathisia aggravatedLLTMedDRA10048563 AkathisiaLLTMedDRA10001540 AkathisiaPTCTCAE Motor restlessnessLLTMedDRA10028006 Motor unrest compulsiveLLTMedDRA10028007 Akathisia C78163 E12581 Alanine aminotransferase increased 10001551 NCIA finding based on laboratory test results that indicate an increase in the level of alanine aminotransferase (ALT or SGPT) in the blood specimen. ALT flare upLLTMedDRA10068307 ALT increasedLLTMedDRA10001845 Alanine aminotransferase increaseLLTMedDRA10001550 Alanine aminotransferase increasedLLTMedDRA10001551 Alanine aminotransferase increasedPTCTCAE GPT increased transientLLTMedDRA10018645 GPT increasedLLTMedDRA10018644 Glutamic-pyruvate transaminase increasedLLTMedDRA10018455 Glutamic-pyruvic transaminase increasedLLTMedDRA10018457 SGPT increasedLLTMedDRA10040526 Serum glutamic-pyruvic ta increasedLLTMedDRA10056502 Serum glutamic-pyruvic transaminase increasedLLTMedDRA10040275 Transaminase glutamic-pyruvic increasedLLTMedDRA10044345 Alanine aminotransferase increased C26948 E12077 Alcohol intolerance 10001598 NCIA disorder characterized by an increase in sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches. Alcohol intoleranceLLTMedDRA10001598 Alcohol intolerancePTCTCAE Alcohol tolerance loweredLLTMedDRA10001609 Alcohol-induced flushingLLTMedDRA10056597 Antabuse effectLLTMedDRA10048558 Disulfiram like reactionLLTMedDRA10013520 Drug-induced alcohol intoleranceLLTMedDRA10056606 Intolerance alcoholicLLTMedDRA10022723 Alcohol intolerance C78167 E12242 Alkaline phosphatase increased 10001675 NCIA finding based on laboratory test results that indicate an increase in the level of alkaline phosphatase in a blood specimen. ALP increasedLLTMedDRA10001771 Al-P increasedLLTMedDRA10001544 Alk phos raisedLLTMedDRA10001669 Alkaline phosphatase NOS increasedLLTMedDRA10001677 Alkaline phosphatase increasedLLTMedDRA10001675 Alkaline phosphatase increasedPTCTCAE Alkaline phosphatase serum increasedLLTMedDRA10001679 Blood alkaline phosphatase NOS increasedLLTMedDRA10005313 Blood alkaline phosphatase bone increasedLLTMedDRA10005302 Blood alkaline phosphatase increasedLLTMedDRA10059570 Blood alkaline phosphatase intestine increasedLLTMedDRA10005306 Blood alkaline phosphatase liver increasedLLTMedDRA10005308 Blood alkaline phosphatase placental increasedLLTMedDRA10005316 Blood alkaline phosphatase renal increasedLLTMedDRA10059584 Bone alkaline phosphatase increasedLLTMedDRA10066809 Phosphatase alkaline increasedLLTMedDRA10034927 Serum alkaline phosphatase elevatedLLTMedDRA10040133 Alkaline phosphatase increased C35607 E12082 Alkalosis 10001680 NCIA disorder characterized by abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues. AlkalaemiaLLTMedDRA10060357 AlkalemiaLLTMedDRA10001671 Alkalosis NOSLLTMedDRA10001687 AlkalosisLLTMedDRA10001680 AlkalosisPTCTCAE Alkalosis C37909 E12247 Allergic reaction 10001718 NCIA disorder characterized by an adverse local or general response from exposure to an allergen. Acute allergic reactionLLTMedDRA10000656 Allergic reaction NOSLLTMedDRA10001719 Allergic reactionLLTMedDRA10001718 Allergic reactionPTCTCAE Allergy NOSLLTMedDRA10001741 Allergy aggravatedLLTMedDRA10001739 AllergyLLTMedDRA10001738 Environmental allergyLLTMedDRA10048696 Hypersensitivity NOSLLTMedDRA10020755 Hypersensitivity reaction (NOS)LLTMedDRA10020757 Hypersensitivity reactionLLTMedDRA10020756 Hypersensitivity symptomLLTMedDRA10020759 HypersensitivityLLTMedDRA10020751 Reaction allergic (NOS)LLTMedDRA10037932 Reaction hypersensitivity (NOS)LLTMedDRA10037948 Red neck syndromeLLTMedDRA10038195 Upper respiratory tract hypersensitivity reaction, site unspecifiedLLTMedDRA10046305 Allergic reaction C3114 E11248 Allergic rhinitis 10001723 NCIA disorder characterized by an inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea and itching. Allergic rhinitis (excl hay fever)LLTMedDRA10001724 Allergic rhinitisLLTMedDRA10001723 Allergic rhinitisPTCTCAE Atopic rhinitisLLTMedDRA10003644 Rhinitis allergic NOSLLTMedDRA10039087 Rhinitis allergic atopicLLTMedDRA10039086 Rhinitis allergicLLTMedDRA10039085 Allergic rhinitis C79532 E13303 Alopecia 10001760 NCIA disorder characterized by a decrease in density of hair compared to normal for a given individual at a given age and body location. Accelerated hair lossLLTMedDRA10000357 Alopecia reversibleLLTMedDRA10001763 Alopecia, unspecifiedLLTMedDRA10001768 AlopeciaLLTMedDRA10001760 AlopeciaPTCTCAE AtrichiaLLTMedDRA10003669 AtrichosisLLTMedDRA10003670 BaldnessLLTMedDRA10004082 Body hair lossLLTMedDRA10064731 Frontal-parietal thinningLLTMedDRA10017380 Hair lossLLTMedDRA10019045 Hair thinningLLTMedDRA10019050 Alopecia C50575 E13611 Amnesia 10001949 NCIA disorder characterized by systematic and extensive loss of memory. Amnesia aggravatedLLTMedDRA10048338 Amnesia transientLLTMedDRA10001951 AmnesiaLLTMedDRA10001949 AmnesiaPTCTCAE Long-term memory lossLLTMedDRA10024806 Losing memory in morningsLLTMedDRA10024848 Loss of memory abilityLLTMedDRA10024872 Loss of memoryLLTMedDRA10024871 Memory loss ofLLTMedDRA10027178 Memory loss transientLLTMedDRA10027179 Memory lossLLTMedDRA10027176 Partial loss of memoryLLTMedDRA10034068 Short-term memory lossLLTMedDRA10040602 Total loss of memoryLLTMedDRA10044096 Amnesia C2867 E12585 Anal fistula 10002156 NCIA disorder characterized by an abnormal communication between the opening in the anal canal to the perianal skin. Anal fistulaLLTMedDRA10002156 Anal fistulaPTCTCAE Anorectal fistulaLLTMedDRA10002645 Fistula analLLTMedDRA10016718 Fistula in anoLLTMedDRA10016721 Perianal fistulaLLTMedDRA10068659 Rectal fistulaLLTMedDRA10038062 Rectum to skin fistulaLLTMedDRA10038102 Anal fistula C60785 E10464 Anal hemorrhage 10055226 NCIA disorder characterized by bleeding from the anal region. Anal bleedingLLTMedDRA10049563 Anal haemorrhageLLTMedDRA10049555 Anal hemorrhageLLTMedDRA10055226 Anal hemorrhagePTCTCAE Perianal bleedingLLTMedDRA10053165 Anal hemorrhage C78168 E10470 Anal mucositis 10065721 NCIA disorder characterized by inflammation of the mucous membrane of the anus. Anal inflammationLLTMedDRA10050247 Anal mucositisLLTMedDRA10065721 Anal mucositisPTCTCAE Inflamed anusLLTMedDRA10050253 Anal mucositis C78170 E10476 Anal necrosis 10065722 NCIA disorder characterized by a necrotic process occurring in the anal region. Anal necrosisLLTMedDRA10065722 Anal necrosisPTCTCAE Duodenal necrosisLLTMedDRA10065725 Esophageal necrosisLLTMedDRA10065727 Gastric necrosisLLTMedDRA10051886 Gastrointestinal necrosisLLTMedDRA10017982 Ileal necrosisLLTMedDRA10065729 Intestinal necrosisLLTMedDRA10022686 Jejunal necrosisLLTMedDRA10065731 Necrosis bowelLLTMedDRA10028856 Necrosis intestinalLLTMedDRA10028861 Oesophageal necrosisLLTMedDRA10065737 Rectal necrosisLLTMedDRA10065709 Small intestinal necrosisLLTMedDRA10065711 Anal necrosis C78171 E10482 Anal pain 10002167 NCIA disorder characterized by a sensation of marked discomfort in the anal region. Anal painLLTMedDRA10002167 Anal painPTCTCAE Anorectal painLLTMedDRA10058446 Anus painLLTMedDRA10002854 Pain analLLTMedDRA10033377 Pain rectalLLTMedDRA10033486 Perianal painLLTMedDRA10067119 ProctalgiaLLTMedDRA10036772 Rectal painLLTMedDRA10038072 Anal pain C78172 E10486 Anal stenosis 10002176 NCIA disorder characterized by a narrowing of the lumen of the anal canal. Anal stenosisLLTMedDRA10002176 Anal stenosisPTCTCAE Anal strictureLLTMedDRA10002177 Anal stenosis C78173 E10490 Anal ulcer 10002180 NCIA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the anal canal. Anal ulcerLLTMedDRA10002180 Anal ulcerPTCTCAE Perianal ulcerLLTMedDRA10063125 Solitary ulcer of anus (sphincter)LLTMedDRA10041313 Stercoral ulcer of anus (sphincter)LLTMedDRA10042001 Ulcer analLLTMedDRA10045286 Ulceration of anusLLTMedDRA10045350 Anal ulcer C79536 E10496 Anaphylaxis 10002218 NCIA disorder characterized by an acute inflammatory reaction resulting from the release of histamine and histamine-like substances from mast cells, causing a hypersensitivity immune response. Clinically, it presents with breathing difficulty, dizziness, hypotension, cyanosis and loss of consciousness and may lead to death. Acute anaphylactic reactionLLTMedDRA10000663 Acute anaphylaxisLLTMedDRA10000664 Anaphylactic reaction to chemicalLLTMedDRA10054845 Anaphylactic reaction to drugLLTMedDRA10054844 Anaphylactic reaction to foodLLTMedDRA10054843 Anaphylactic reaction to vaccineLLTMedDRA10063979 Anaphylactic reactionLLTMedDRA10002198 AnaphylaxisLLTMedDRA10002218 AnaphylaxisPTCTCAE Exercise-induced anaphylaxisLLTMedDRA10060689 Systemic allergic reactionLLTMedDRA10066472 Systemic anaphylactic reactionLLTMedDRA10042930 Systemic anaphylaxisLLTMedDRA10042931 Anaphylaxis C50460 E11254 Anemia 10002272 NCIA disorder characterized by an reduction in the amount of hemoglobin in 100 ml of blood. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability. AnemiaPTCTCAE Anemia C2869 E10010 Ankle fracture 10002544 NCIA finding of damage to the ankle joint characterized by a break in the continuity of the ankle bone. Symptoms include marked discomfort, swelling and difficulty moving the affected leg and foot. Ankle fracturePTCTCAE Ankle fracture C26989 E11640 Anorectal infection 10061640 NCIA disorder characterized by an infectious process involving the anal area and the rectum. Ano-rectal infection NOSLLTMedDRA10002579 Anorectal infectionLLTMedDRA10061640 Anorectal infectionPTCTCAE Anorectal infection C78174 E11286 Anorexia 10002646 NCIA disorder characterized by a loss of appetite. AnorecticLLTMedDRA10052625 Anorexia post chemotherapyLLTMedDRA10066197 AnorexiaLLTMedDRA10002646 AnorexiaPTCTCAE Appetite absentLLTMedDRA10003017 Appetite lostLLTMedDRA10003028 HyporexiaLLTMedDRA10067342 InappetenceLLTMedDRA10054792 Anorexia C2875 E12252 Anorgasmia 10002652 NCIA disorder characterized by an inability to achieve orgasm. AnorgasmiaLLTMedDRA10002652 AnorgasmiaPTCTCAE Inability to orgasmLLTMedDRA10021574 Anorgasmia C78177 E12880 Anxiety 10002855 NCIA disorder characterized by apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus. Angor animiLLTMedDRA10002505 AnguishLLTMedDRA10002507 Anxiety aggravatedLLTMedDRA10048339 Anxiety attackLLTMedDRA10002856 Anxiety complexLLTMedDRA10002857 Anxiety reactionLLTMedDRA10002865 Anxiety state, unspecifiedLLTMedDRA10002867 Anxiety stateLLTMedDRA10002866 Anxiety symptoms NOSLLTMedDRA10002870 Anxiety-riddenLLTMedDRA10002871 AnxietyLLTMedDRA10002855 AnxietyPTCTCAE Anxious moodLLTMedDRA10002875 ApprehensionLLTMedDRA10003061 Chronic anxietyLLTMedDRA10066549 Exacerbation of anxietyLLTMedDRA10015574 Feeling anxiousLLTMedDRA10016323 Feeling of intense apprehensionLLTMedDRA10016351 Impending doomLLTMedDRA10021527 Made anxiety worseLLTMedDRA10025426 Phobic anxietyLLTMedDRA10034917 Reaction alarmLLTMedDRA10037931 Reaction anxietyLLTMedDRA10037935 Separation anxietyLLTMedDRA10040044 Situational anxietyLLTMedDRA10040760 WorryLLTMedDRA10048025 Anxiety C26696 E12883 Aortic injury 10002899 NCIA finding of damage to the aorta. Aortic injuryLLTMedDRA10002899 Aortic injuryPTCTCAE Injury to abdominal aortaLLTMedDRA10022125 Injury to thoracic aortaLLTMedDRA10022358 Aortic injury C35623 E11644 Aortic valve disease 10061589 NCIA disorder characterized by a defect in aortic valve function or structure. Aortic valve disease NOSLLTMedDRA10002913 Aortic valve diseaseLLTMedDRA10061589 Aortic valve diseasePTCTCAE Diseases of aortic valveLLTMedDRA10013118 Aortic valve disease C78650 E10071 Aphonia 10002953 NCIA disorder characterized by the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic). AphoniaLLTMedDRA10002953 AphoniaPTCTCAE Loss of voiceLLTMedDRA10024882 VoicelessnessLLTMedDRA10059792 Aphonia C79539 E12589 Apnea 10002972 NCIA disorder characterized by cessation of breathing. ApneaLLTMedDRA10002972 ApneaPTCTCAE ApnoeaLLTMedDRA10002974 Apnea C26698 E13306 Appendicitis 10003011 NCIA disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent. Acute appendicitisLLTMedDRA10000677 Appendicitis, unqualifiedLLTMedDRA10003014 AppendicitisLLTMedDRA10003011 AppendicitisPTCTCAE Gangrenous appendicitisLLTMedDRA10059632 Necrotising appendicitisLLTMedDRA10066023 Necrotizing appendicitisLLTMedDRA10066038 Purulent appendicitisLLTMedDRA10057883 Unqualified appendicitisLLTMedDRA10045550 Appendicitis C35145 E11292 Appendicitis perforated 10003012 NCIA disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity. Appendicitis perforatedLLTMedDRA10003012 Appendicitis perforatedPTCTCAE Appendicitis purulent perforatedLLTMedDRA10003013 Ruptured appendixLLTMedDRA10049137 Appendicitis perforated C78178 E11296 Arachnoiditis 10003074 NCIA disorder characterized by inflammation of the arachnoid membrane and adjacent subarachnoid space. Adhesive arachnitisLLTMedDRA10001285 ArachnitisLLTMedDRA10003073 Arachnoiditis adhesive chronicLLTMedDRA10003075 ArachnoiditisLLTMedDRA10003074 ArachnoiditisPTCTCAE Meningitis serosa circumscriptaLLTMedDRA10068741 Spinal arachnoiditisLLTMedDRA10068160 Arachnoiditis C37913 E12591 Arterial injury 10003162 NCIA finding of damage to an artery. Arterial injuryLLTMedDRA10003162 Arterial injuryPTCTCAE Femoral artery injuryLLTMedDRA10016429 Injury to anterior tibial arteryLLTMedDRA10022133 Injury to axillary arteryLLTMedDRA10022139 Injury to carotid artery, unspecifiedLLTMedDRA10022162 Injury to carotid arteryLLTMedDRA10022161 Injury to common carotid arteryLLTMedDRA10022172 Injury to common femoral arteryLLTMedDRA10022173 Injury to external carotid arteryLLTMedDRA10022188 Injury to gastric arteryLLTMedDRA10022194 Injury to hepatic arteryLLTMedDRA10022202 Injury to hypogastric arteryLLTMedDRA10022204 Injury to iliac arteryLLTMedDRA10022207 Injury to inferior mesenteric arteryLLTMedDRA10022211 Injury to internal carotid arteryLLTMedDRA10022218 Injury to ovarian arteryLLTMedDRA10022291 Injury to palmar arteryLLTMedDRA10022293 Injury to popliteal arteryLLTMedDRA10022308 Injury to posterior tibial arteryLLTMedDRA10022314 Injury to primary branches of superior mesenteric arteryLLTMedDRA10022317 Injury to pulmonary arteryLLTMedDRA10022318 Injury to renal arteryLLTMedDRA10022327 Injury to splenic arteryLLTMedDRA10022348 Injury to superficial femoral arteryLLTMedDRA10022352 Injury to superior mesenteric artery (trunk)LLTMedDRA10022354 Injury to uterine arteryLLTMedDRA10022385 Radial artery injuryLLTMedDRA10037745 Arterial injury C35401 E11648 Arteritis infective 10065744 NCIA disorder characterized by an infectious process involving an artery. Arteritis infectiveLLTMedDRA10065744 Arteritis infectivePTCTCAE Arteritis infective C34399 E11301 Arthralgia 10003239 NCIA disorder characterized by a sensation of marked discomfort in a joint. Ache wristsLLTMedDRA10000430 Aching (l) kneeLLTMedDRA10000444 Aching (r) kneeLLTMedDRA10000445 Aching in kneesLLTMedDRA10000447 Aching jointsLLTMedDRA10000449 Arthralgia aggravatedLLTMedDRA10003240 Arthralgia lumbarLLTMedDRA10003241 Arthralgia multipleLLTMedDRA10003242 Arthralgia of temporomandibular jointLLTMedDRA10003243 ArthralgiaLLTMedDRA10003239 ArthralgiaPTCTCAE Arthritic painsLLTMedDRA10003244 Arthritic-like painLLTMedDRA10003245 CoxalgiaLLTMedDRA10011249 CoxodyniaLLTMedDRA10068552 Generalised joint painsLLTMedDRA10018086 Generalized joint painLLTMedDRA10062438 GonalgiaLLTMedDRA10064238 Joint acheLLTMedDRA10023197 Joint painLLTMedDRA10023222 Joint tendernessLLTMedDRA10048913 Knee painLLTMedDRA10023477 Pain ankleLLTMedDRA10033379 Pain in ankleLLTMedDRA10033420 Pain in elbowLLTMedDRA10033424 Pain in hipLLTMedDRA10033432 Pain in joint involving forearmLLTMedDRA10033436 Pain in joint involving handLLTMedDRA10033437 Pain in joint involving lower legLLTMedDRA10033438 Pain in joint involving shoulder regionLLTMedDRA10033442 Pain in joint involving upper armLLTMedDRA10033443 Pain in joint, site unspecifiedLLTMedDRA10033444 Pain in jointLLTMedDRA10033434 Pain in kneeLLTMedDRA10033445 Pain jointLLTMedDRA10033456 Pain kneeLLTMedDRA10033458 Pain sacroiliacLLTMedDRA10033491 Painful ankleLLTMedDRA10033501 Painful hipsLLTMedDRA10033509 Painful jointsLLTMedDRA10033511 Painful kneeLLTMedDRA10033512 PolyarthralgiaLLTMedDRA10036029 Rheumatism (joints only)LLTMedDRA10039071 Sacro-iliac painLLTMedDRA10039354 Shoulder pain (due joint disorder)LLTMedDRA10040618 Temporomandibular joint arthralgiaLLTMedDRA10043215 Wrist painLLTMedDRA10048692 Arthralgia C50464 E12374 Arthritis 10003246 NCIA disorder characterized by inflammation involving a joint. Acute arthritisLLTMedDRA10066547 Arthritis NOS aggravatedLLTMedDRA10003264 Arthritis NOSLLTMedDRA10003263 Arthritis aggravatedLLTMedDRA10003247 Arthritis flare upLLTMedDRA10060697 ArthritisLLTMedDRA10003246 ArthritisPTCTCAE Atrophic arthritisLLTMedDRA10003683 Chronic arthritisLLTMedDRA10066550 CoxarthritisLLTMedDRA10049008 CoxitisLLTMedDRA10059154 Finger arthritisLLTMedDRA10065266 Flare up of arthritisLLTMedDRA10016751 GonarthritisLLTMedDRA10056617 GonitisLLTMedDRA10068669 Joint inflammationLLTMedDRA10023217 Joint swelling inflammatoryLLTMedDRA10023233 Knee arthritisLLTMedDRA10067624 OmarthritisLLTMedDRA10062687 Arthritis C2883 E12378 Ascites 10003445 NCIA disorder characterized by accumulation of serous or hemorrhagic fluid in the peritoneal cavity. Ascites chylousLLTMedDRA10003446 AscitesLLTMedDRA10003445 AscitesPTCTCAE Chylous ascitesLLTMedDRA10009167 Peritoneal effusion (chronic)LLTMedDRA10034663 Ascites C2885 E10502 Aspartate aminotransferase increased 10003481 NCIA finding based on laboratory test results that indicate an increase in the level of aspartate aminotransferase (AST or SGOT) in a blood specimen. AST increasedLLTMedDRA10003544 Aspartate aminotransferase increaseLLTMedDRA10003480 Aspartate aminotransferase increasedLLTMedDRA10003481 Aspartate aminotransferase increasedPTCTCAE GOT increased transientLLTMedDRA10018625 GOT increasedLLTMedDRA10018624 Glutamic-oxaloacetic transaminase increasedLLTMedDRA10018452 SGOT increasedLLTMedDRA10040524 Serum glutamic-oxaloacetic ta increasedLLTMedDRA10040271 Serum glutamic-oxaloacetic transaminase increasedLLTMedDRA10040272 Transaminase glutamic-oxalacetic increasedLLTMedDRA10044344 Aspartate aminotransferase increased C26947 E12087 Aspiration 10003504 NCIA disorder characterized by inhalation of solids or liquids into the lungs. Aspiration of gastrointestinal contents into airwaysLLTMedDRA10048996 AspirationLLTMedDRA10003504 AspirationPTCTCAE Aspiration C15631 E13310 Asystole 10003586 NCIA disorder characterized by a dysrhythmia without cardiac electrical activity. Typically, this is accompanied by cessation of the pumping function of the heart. Arrest cardiacLLTMedDRA10003109 AsystoleLLTMedDRA10003586 AsystolePTCTCAE AsystoliaLLTMedDRA10003587 AsystolicLLTMedDRA10003589 Cardiac arrest transientLLTMedDRA10007517 Cardiac arrestLLTMedDRA10007515 Congestive cardioplegiaLLTMedDRA10010683 Heart arrestLLTMedDRA10019249 Hypoxic arrestLLTMedDRA10021145 Standstill cardiacLLTMedDRA10041914 Asystole C50479 E10077 Ataxia 10003591 NCIA disorder characterized by lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities. Ataxia aggravatedLLTMedDRA10048320 AtaxiaLLTMedDRA10003591 AtaxiaPTCTCAE Ataxic gaitLLTMedDRA10003597 AtaxicLLTMedDRA10003596 Ataxia C26702 E12597 Atelectasis 10003598 NCIA disorder characterized by the collapse of part or the entire lung. AtelectasisLLTMedDRA10003598 AtelectasisPTCTCAE Lobar collapseLLTMedDRA10024737 Atelectasis C2888 E13316 Atrial fibrillation 10003658 NCIA disorder characterized by a dysrhythmia without discernible P waves and an irregular ventricular response due to multiple reentry circuits. The rhythm disturbance originates above the ventricles. AFibLLTMedDRA10001452 Alcoholic atrial fibrillationLLTMedDRA10001614 Arrhythmia absolutaLLTMedDRA10059122 Atrial fibrillation aggravatedLLTMedDRA10003659 Atrial fibrillation paroxysmalLLTMedDRA10003661 Atrial fibrillation with rapid ventricular responseLLTMedDRA10058331 Atrial fibrillationLLTMedDRA10003658 Atrial fibrillationPTCTCAE Auricular fibrillationLLTMedDRA10003796 Chronic atrial fibrillationLLTMedDRA10066551 Fibrillation atrial aggravatedLLTMedDRA10016567 Fibrillation atrialLLTMedDRA10016566 Fibrillation paroxysmal atrialLLTMedDRA10016570 Paroxysmal atrial fibrillationLLTMedDRA10034039 Recurrent atrial fibrillationLLTMedDRA10066582 Recurrent symptomatic atrial fibrillationLLTMedDRA10066664 Atrial fibrillation C50466 E10081 Atrial flutter 10003662 NCIA disorder characterized by a dysrhythmia with organized rhythmic atrial contractions with a rate of 200-300 beats per minute. The rhythm disturbance originates in the atria. Atrial flutterLLTMedDRA10003662 Atrial flutterPTCTCAE Flutter atrialLLTMedDRA10016827 Paroxysmal atrial flutterLLTMedDRA10050376 Atrial flutter C51224 E10087 Atrioventricular block complete 10003673 NCIA disorder characterized by a dysrhythmia with complete failure of atrial electrical impulse conduction through the AV node to the ventricles. AV block completeLLTMedDRA10003848 AV block third degreeLLTMedDRA10003852 Atrioventricular block completeLLTMedDRA10003673 Atrioventricular block completePTCTCAE Atrioventricular block third degreeLLTMedDRA10065659 Atrioventricular block, completeLLTMedDRA10003678 Complete heart blockLLTMedDRA10010141 Heart block AV complete with asystoleLLTMedDRA10019257 Heart block AV completeLLTMedDRA10019256 Heart block AV third degreeLLTMedDRA10019260 Heart block completeLLTMedDRA10019262 Heart block third degreeLLTMedDRA10019271 Third degree AV blockLLTMedDRA10043440 Transient AV block completeLLTMedDRA10066166 Atrioventricular block complete C50501 E10093 Atrioventricular block first degree 10003674 NCIA disorder characterized by a dysrhythmia with a delay in the time required for the conduction of an electrical impulse through the atrioventricular (AV) node beyond 0.2 seconds; prolongation of the PR interval greater than 200 milliseconds. 1st degree heart blockLLTMedDRA10000018 AV block first degreeLLTMedDRA10003850 Atrioventricular block first degreeLLTMedDRA10003674 Atrioventricular block first degreePTCTCAE Atrioventricular conduction time prolongedLLTMedDRA10003681 First degree atrioventricular blockLLTMedDRA10016699 Heart block 1st degreeLLTMedDRA10019253 Heart block AV first degreeLLTMedDRA10019258 Heart block first degreeLLTMedDRA10019264 Atrioventricular block first degree C62015 E10098 Autoimmune disorder 10061664 NCIA disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents. Autoimmune deficiency syndromeLLTMedDRA10003813 Autoimmune disorder NOSLLTMedDRA10003815 Autoimmune disorderLLTMedDRA10061664 Autoimmune disorderPTCTCAE Autoimmune disorder C2889 E11258 Avascular necrosis 10066480 NCIA disorder characterized by necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure. Aseptic necrosis boneLLTMedDRA10003460 Aseptic necrosis of bone, site unspecifiedLLTMedDRA10003462 Aseptic necrosis of boneLLTMedDRA10003461 Aseptic necrosis of head and neck of femurLLTMedDRA10003463 Aseptic necrosis of head of humerusLLTMedDRA10003464 Aseptic necrosis of jawLLTMedDRA10064656 Aseptic necrosis of medial femoral condyleLLTMedDRA10003465 Aseptic necrosis of talusLLTMedDRA10003467 Aseptic necrosisLLTMedDRA10003459 Avascular necrosis femoral headLLTMedDRA10003860 Avascular necrosis of boneLLTMedDRA10003861 Avascular necrosisLLTMedDRA10066480 Avascular necrosisPTCTCAE Bone necrosisLLTMedDRA10005994 Carpal collapseLLTMedDRA10062686 Metacarpal collapseLLTMedDRA10067504 Necrosis boneLLTMedDRA10028855 Osteonecrosis of jawLLTMedDRA10064658 OsteonecrosisLLTMedDRA10031264 Avascular necrosis C34880 E12382 Azoospermia 10003883 NCIA disorder characterized by laboratory test results that indicate complete absence of spermatozoa in the semen. AzoospermiaPTCTCAE Azoospermia C80076 E13067 Back pain 10003988 NCIA disorder characterized by marked discomfort sensation in the back region. Acute back painLLTMedDRA10000683 Acute lumbagoLLTMedDRA10052429 Back acheLLTMedDRA10003978 Back distressLLTMedDRA10003985 Back pain (with radiation)LLTMedDRA10003989 Back pain (without radiation)LLTMedDRA10003990 Back pain aggravatedLLTMedDRA10048412 Back painLLTMedDRA10003988 Back painPTCTCAE Backache, unspecifiedLLTMedDRA10003994 BackacheLLTMedDRA10003993 Chronic back painLLTMedDRA10008837 Chronic lumbagoLLTMedDRA10052430 Dorsal painLLTMedDRA10013601 DorsalgiaLLTMedDRA10064734 Loin painLLTMedDRA10024798 Low back acheLLTMedDRA10024890 Low back pain (without radiation)LLTMedDRA10024892 Low back painLLTMedDRA10024891 Lumbago (excl lumbar disc lesion)LLTMedDRA10024989 LumbagoLLTMedDRA10024988 Lumbar painLLTMedDRA10024998 Lumbar syndromeLLTMedDRA10066910 Lumbo-sacral painLLTMedDRA10025012 Other back pain with radiating symptomsLLTMedDRA10031675 Pain backLLTMedDRA10033380 Pain dorsalLLTMedDRA10033391 Pain loinLLTMedDRA10033460 Pain lumbosacralLLTMedDRA10033462 Pain over the backLLTMedDRA10033478 Sacral painLLTMedDRA10048710 Sore backLLTMedDRA10041353 Upper back painLLTMedDRA10046273 Back pain C41830 E12388 Bile duct stenosis 10051341 NCIA disorder characterized by a narrowing of the lumen of the bile duct. Benign choledochal strictureLLTMedDRA10004248 Bile duct stenosisLLTMedDRA10051341 Bile duct stenosisPTCTCAE Bile duct strictureLLTMedDRA10004640 Choledochus stenosisLLTMedDRA10049892 Distal bile duct strictureLLTMedDRA10013472 Hepatic duct stenosisLLTMedDRA10054847 Multiple intrahepatic bile duct stricturesLLTMedDRA10028226 Bile duct stenosis C78182 E11173 Biliary anastomotic leak 10050458 NCIA finding of leakage of bile due to breakdown of a biliary anastomosis (surgical connection of two separate anatomic structures). Biliary anastomotic leakLLTMedDRA10050458 Biliary anastomotic leakPTCTCAE Post procedural bile leakLLTMedDRA10057586 Biliary anastomotic leak C78183 E11654 Biliary fistula 10004665 NCIA disorder characterized by an abnormal communication between the bile ducts and another organ or anatomic site. Biliary fistulaLLTMedDRA10004665 Biliary fistulaPTCTCAE Fistula of bile ductLLTMedDRA10016725 Biliary fistula C79540 E11179 Biliary tract infection 10061695 NCIA disorder characterized by an infectious process involving the biliary tract. Biliary tract infection NOSLLTMedDRA10051019 Biliary tract infectionLLTMedDRA10061695 Biliary tract infectionPTCTCAE Biliary tract infection C26718 E11305 Bladder anastomotic leak 10065802 NCIA finding of leakage of urine due to breakdown of a bladder anastomosis (surgical connection of two separate anatomic structures). Bladder anastomotic leakLLTMedDRA10065802 Bladder anastomotic leakPTCTCAE Kidney anastomotic leakLLTMedDRA10065803 Ureteric anastomotic leakLLTMedDRA10065814 Urethral anastomotic leakLLTMedDRA10065815 Urinary anastomotic leakLLTMedDRA10060775 Bladder anastomotic leak C78206 E11660 Bladder infection 10005047 NCIA disorder characterized by an infectious process involving the bladder. Acute cystitis (excl in pregnancy)LLTMedDRA10000699 Acute cystitisLLTMedDRA10000698 Bladder infection NOSLLTMedDRA10005048 Bladder infectionLLTMedDRA10005047 Bladder infectionPTCTCAE Cystitis NOSLLTMedDRA10011798 Cystitis acute NOSLLTMedDRA10011784 Cystitis acuteLLTMedDRA10011783 Cystitis aggravatedLLTMedDRA10011785 Cystitis, unspecifiedLLTMedDRA10011802 CystitisLLTMedDRA10011781 Infection bladderLLTMedDRA10021805 PyocystitisLLTMedDRA10069027 Bladder infection C26738 E11309 Bladder perforation 10063575 NCIA disorder characterized by a rupture in the bladder wall. Bladder perforation postoperativeLLTMedDRA10005066 Bladder perforationLLTMedDRA10063575 Bladder perforationPTCTCAE Perforated bladder (surgical complication)LLTMedDRA10034384 Urinary bladder perforation interoperativeLLTMedDRA10050509 Bladder perforation C78208 E12979 Bladder spasm 10048994 NCIA disorder characterized by a sudden and involuntary contraction of the bladder wall. Bladder spasmLLTMedDRA10048994 Bladder spasmPTCTCAE Vesical tenesmusLLTMedDRA10047366 Bladder spasm C78210 E12984 Bloating 10005265 NCIA disorder characterized by subject-reported feeling of uncomfortable fullness of the abdomen. Abdomen enlarged feeling ofLLTMedDRA10000046 Abdomen enlargedLLTMedDRA10000045 Abdominal bloatingLLTMedDRA10048746 Abdominal distension gaseousLLTMedDRA10000061 Abdominal distensionLLTMedDRA10000060 Abdominal fullnessLLTMedDRA10000065 Bloated feeling generalLLTMedDRA10050472 Bloated feelingLLTMedDRA10005264 Bloating NOSLLTMedDRA10005267 BloatingLLTMedDRA10005265 BloatingPTCTCAE Distended abdomenLLTMedDRA10013480 Distension NOSLLTMedDRA10013481 DistentionLLTMedDRA10013482 Enlargement abdomenLLTMedDRA10014842 Epigastric fullnessLLTMedDRA10015018 Feeling of fullness in abdomenLLTMedDRA10016348 Feeling of gastrointestinal fullnessLLTMedDRA10016349 Fullness abdominalLLTMedDRA10017467 Gastrointestinal fullnessLLTMedDRA10017953 Stomach fullnessLLTMedDRA10042106 Swelling abdLLTMedDRA10042678 Swelling abdomenLLTMedDRA10042679 Swollen abdomenLLTMedDRA10042714 Bloating C78213 E10508 Blood and lymphatic system disorders 10005329 Blood and lymphatic system disordersPTCTCAE Blood and lymphatic system disorders E13857 Blood and lymphatic system disorders - Other, specify Blood and lymphatic system disorders - Other, specifyPTCTCAE Blood and lymphatic system disorders - Other, specify E10016 Blood antidiuretic hormone abnormal 10005332 NCIA finding based on laboratory test results that indicate abnormal levels of antidiuretic hormone in the blood specimen. ADH abnormalLLTMedDRA10001266 Blood antidiuretic hormone abnormal NOSLLTMedDRA10005333 Blood antidiuretic hormone abnormalLLTMedDRA10005332 Blood antidiuretic hormone abnormalPTCTCAE Plasma antidiuretic hormone abnormalLLTMedDRA10035185 Serum antidiuretic hormone abnormalLLTMedDRA10040141 Vasopressin abnormal NOSLLTMedDRA10047148 Vasopressin abnormalLLTMedDRA10047147 Blood antidiuretic hormone abnormal C78214 E12092 Blood bilirubin increased 10005364 NCIA finding based on laboratory test results that indicate an abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice. Blood bilirubin increasedPTCTCAE Blood bilirubin increased C27088 E12096 Blood corticotrophin decreased 10005452 NCIA finding based on laboratory test results that indicate an decrease in levels of corticotrophin in a blood specimen. ACTH decreasedLLTMedDRA10000610 Adrenocorticotropin decreasedLLTMedDRA10001397 Blood corticotrophin decreasedLLTMedDRA10005452 Blood corticotrophin decreasedPTCTCAE Corticotrophin decreasedLLTMedDRA10011186 Corticotropin decreasedLLTMedDRA10011190 Corticotropin lowLLTMedDRA10011193 Plasma corticotrophin decreasedLLTMedDRA10035258 Serum corticotrophin decreasedLLTMedDRA10040213 Blood corticotrophin decreased C78215 E12101 Blood gonadotrophin abnormal 10005561 NCIA finding based on laboratory test results that indicate abnormal levels of gonadotrophin hormone in a blood specimen. Blood gonadotrophin abnormalLLTMedDRA10005561 Blood gonadotrophin abnormalPTCTCAE Gonadotrophins NOS abnormalLLTMedDRA10018521 Gonadotropins NOS abnormalLLTMedDRA10018548 Pituitary gonadotrophin abnormalLLTMedDRA10054714 Plasma gonadotrophin abnormalLLTMedDRA10035309 Serum gonadotrophin abnormalLLTMedDRA10040277 Blood gonadotrophin abnormal C78216 E12105 Blood prolactin abnormal 10005778 NCIA finding based on laboratory test results that indicate abnormal levels of prolactin hormone in a blood specimen. Blood prolactin abnormalLLTMedDRA10005778 Blood prolactin abnormalPTCTCAE Plasma prolactin abnormalLLTMedDRA10035413 Prolactin abnormal NOSLLTMedDRA10036823 Serum prolactin abnormalLLTMedDRA10040382 Blood prolactin abnormal C78217 E12109 Blurred vision 10005886 NCIA disorder characterized by visual perception of unclear or fuzzy images. Blurred visionLLTMedDRA10005886 Blurred visionPTCTCAE Blurring of eyesLLTMedDRA10005887 Blurring of visionLLTMedDRA10005888 Blurry visionLLTMedDRA10005889 Cloudy visionLLTMedDRA10060817 Difficulty focusing eyesLLTMedDRA10012792 Filmy visionLLTMedDRA10060816 Fog in front of eyesLLTMedDRA10016875 Hazy visionLLTMedDRA10060818 Nephelopia transientLLTMedDRA10049064 NephelopiaLLTMedDRA10049063 Nephelopsia transientLLTMedDRA10029115 Unable to focusLLTMedDRA10045473 Vision blurredLLTMedDRA10047513 Blurred vision C27123 E10346 Body odor 10005901 NCIA disorder characterized by an abnormal body smell resulting from the growth of bacteria on the body. Body odorLLTMedDRA10005901 Body odorPTCTCAE Body odourLLTMedDRA10005902 Body smell alteredLLTMedDRA10005905 Odor bodyLLTMedDRA10030092 Odour bodyLLTMedDRA10055963 Skin odor abnormalLLTMedDRA10040903 Skin odour abnormalLLTMedDRA10040904 Smelly bodyLLTMedDRA10041219 Smelly feetLLTMedDRA10041221 Sweat odor abnormalLLTMedDRA10063962 Sweat odour abnormalLLTMedDRA10063964 Body odor C79542 E13614 Bone infection 10061017 NCIA disorder characterized by an infectious process involving the bones. Bone infection NOSLLTMedDRA10005977 Bone infectionLLTMedDRA10061017 Bone infectionPTCTCAE Hip osteomyelitisLLTMedDRA10020101 Orbital osteomyelitisLLTMedDRA10031052 Osteomyelitis NOSLLTMedDRA10031259 Osteomyelitis aggravatedLLTMedDRA10066711 Osteomyelitis of jawLLTMedDRA10064657 Osteomyelitis recurrentLLTMedDRA10066712 OsteomyelitisLLTMedDRA10031252 Spinal osteomyelitisLLTMedDRA10061562 Unspecified infection of bone of shoulder regionLLTMedDRA10045931 Unspecified infection of bone, forearmLLTMedDRA10045933 Unspecified infection of bone, handLLTMedDRA10045934 Unspecified infection of bone, lower legLLTMedDRA10045935 Unspecified infection of bone, site unspecifiedLLTMedDRA10045936 Unspecified infection of bone, upper armLLTMedDRA10045937 Unspecified infection of boneLLTMedDRA10045927 Unspecified osteomyelitis involving forearmLLTMedDRA10046078 Unspecified osteomyelitis involving handLLTMedDRA10046079 Unspecified osteomyelitis involving lower legLLTMedDRA10046080 Unspecified osteomyelitis involving shoulder regionLLTMedDRA10046084 Unspecified osteomyelitis involving upper armLLTMedDRA10046085 Unspecified osteomyelitis, site unspecifiedLLTMedDRA10046086 Unspecified osteomyelitisLLTMedDRA10046076 Bone infection C26839 E11314 Bone marrow hypocellular 10048580 NCIA disorder characterized by the inability of the bone marrow to produce hematopoietic elements. Aplasia bone marrowLLTMedDRA10002962 Aplastic marrowLLTMedDRA10002971 Bone marrow aplasticLLTMedDRA10005980 Bone marrow depression NOSLLTMedDRA10005987 Bone marrow depressionLLTMedDRA10005986 Bone marrow failureLLTMedDRA10065553 Bone marrow hypocellularLLTMedDRA10048580 Bone marrow hypocellularPTCTCAE Depression bone marrow (NOS)LLTMedDRA10012381 Haematopoiesis decreasedLLTMedDRA10018860 Haematopoiesis depressedLLTMedDRA10060471 Haematopoiesis impairedLLTMedDRA10018861 Haematopoiesis suppressedLLTMedDRA10018863 Haemopoiesis decreasedLLTMedDRA10018961 Haemopoiesis impairedLLTMedDRA10018962 Haemopoiesis suppressedLLTMedDRA10018963 Hematopoiesis decreasedLLTMedDRA10060601 Hematopoiesis depressedLLTMedDRA10019444 Hematopoiesis impairedLLTMedDRA10019445 Hematopoiesis suppressedLLTMedDRA10019447 Hemopoiesis decreasedLLTMedDRA10060633 Hemopoiesis impairedLLTMedDRA10060634 Hemopoiesis suppressedLLTMedDRA10060635 Hypocellular marrowLLTMedDRA10020954 Hypoplasia bone marrowLLTMedDRA10021069 Hypoplasia erythroidLLTMedDRA10021072 Hypoplastic marrowLLTMedDRA10021077 Marrow depression ofLLTMedDRA10026848 Marrow depressionLLTMedDRA10026846 Marrow hypoplasiaLLTMedDRA10026853 Myelosuppression adultLLTMedDRA10028585 MyelosuppressionLLTMedDRA10028584 Bone marrow hypocellular C35167 E10022 Bone pain 10006002 NCIA disorder characterized by marked discomfort sensation in the bones. Bone pain aggravatedLLTMedDRA10006003 Bone painLLTMedDRA10006002 Bone painPTCTCAE Bone tendernessLLTMedDRA10065017 External tibial bone painfulLLTMedDRA10015758 OsteoneuralgiaLLTMedDRA10031265 Pain boneLLTMedDRA10033384 Pain femoralLLTMedDRA10033398 Pain in spineLLTMedDRA10052060 Pain in thoracic spineLLTMedDRA10033450 RachialgiaLLTMedDRA10050175 Skeletal painLLTMedDRA10040777 Tibia painLLTMedDRA10043828 Bone pain C38644 E12392 Brachial plexopathy 10065417 NCIA disorder characterized by regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand. Brachial plexopathyLLTMedDRA10065417 Brachial plexopathyPTCTCAE Brachial plexus lesion (excl neuritis)LLTMedDRA10006076 Brachial plexus lesionLLTMedDRA10006075 Brachial plexopathy C27194 E12601 Breast atrophy 10006179 NCIA disorder characterized by underdevelopment of the breast. Atrophy breastLLTMedDRA10003699 Atrophy of breastLLTMedDRA10003705 Breast atrophyLLTMedDRA10006179 Breast atrophyPTCTCAE Breast size decreaseLLTMedDRA10006309 MastatrophyLLTMedDRA10026877 Breast atrophy C83494 E13069 Breast infection 10006259 NCIA disorder characterized by an infectious process involving the breast. Breast infection NOSLLTMedDRA10006260 Breast infectionLLTMedDRA10006259 Breast infectionPTCTCAE Infection breastLLTMedDRA10021806 Unspecified infection of the breast and nipple associated with childbirthLLTMedDRA10045938 Breast infection C53662 E11318 Breast pain 10006298 NCIA disorder characterized by marked discomfort sensation in the breast region. Ache breastLLTMedDRA10000426 Breast pain femaleLLTMedDRA10006299 Breast pain maleLLTMedDRA10006300 Breast painLLTMedDRA10006298 Breast painPTCTCAE Mastalgia maleLLTMedDRA10051465 MastalgiaLLTMedDRA10026876 MastodyniaLLTMedDRA10026892 Pain breastLLTMedDRA10033385 Painful breastsLLTMedDRA10033504 Sore breastsLLTMedDRA10041354 Soreness breastLLTMedDRA10041370 Breast pain C78223 E13073 Bronchial fistula 10006437 NCIA disorder characterized by an abnormal communication between the bronchus and another organ or anatomic site. Bronchial fistulaLLTMedDRA10006437 Bronchial fistulaPTCTCAE Fistula bronchialLLTMedDRA10016720 Bronchial fistula C79543 E13322 Bronchial infection 10055078 NCIA disorder characterized by an infectious process involving the bronchi. Acute bronchitisLLTMedDRA10000687 Acute exacerbation of chronic bronchitis NOSLLTMedDRA10000744 Acute exacerbation of chronic bronchitisLLTMedDRA10000743 Acute on chronic bronchitisLLTMedDRA10000950 Asthmatoid bronchitisLLTMedDRA10003568 Bronchial infectionLLTMedDRA10055078 Bronchial infectionPTCTCAE Bronchitis NOSLLTMedDRA10006461 Bronchitis acute NOSLLTMedDRA10006453 Bronchitis acuteLLTMedDRA10006452 BronchitisLLTMedDRA10006451 LaryngotracheobronchitisLLTMedDRA10023898 Obstructive bronchitisLLTMedDRA10065682 PeribronchitisLLTMedDRA10049112 Spastic bronchitisLLTMedDRA10068550 Tracheo-laryngeal bronchitis NOSLLTMedDRA10044309 Tracheo-laryngeal bronchitisLLTMedDRA10044308 Wheezy bronchitisLLTMedDRA10047928 Bronchial infection C2911 E11323 Bronchial obstruction 10006440 NCIA disorder characterized by blockage of a bronchus passage, most often by bronchial secretions and exudates. Bronchial obstructionLLTMedDRA10006440 Bronchial obstructionPTCTCAE Obstruction bronchialLLTMedDRA10029938 Bronchial obstruction C78225 E13328 Bronchial stricture 10063524 NCIA disorder characterized by a narrowing of the bronchial tube. Bronchial strictureLLTMedDRA10063524 Bronchial stricturePTCTCAE BronchostenosisLLTMedDRA10006487 Stenosis bronchialLLTMedDRA10041976 Stenosis of bronchusLLTMedDRA10041982 Bronchial stricture C78226 E13334 Bronchopleural fistula 10053481 NCIA disorder characterized by an abnormal communication between a bronchus and the pleural cavity. Bronchopleural fistulaPTCTCAE Bronchopleural fistula C80694 E13340 Bronchopulmonary hemorrhage 10065746 NCIA disorder characterized by bleeding from the bronchial wall and/or lung parenchyma. Bronchopulmonary haemorrhageLLTMedDRA10065756 Bronchopulmonary hemorrhageLLTMedDRA10065746 Bronchopulmonary hemorrhagePTCTCAE Haemorrhage lungLLTMedDRA10055822 Haemorrhage pulmonaryLLTMedDRA10055841 Hemorrhage lungLLTMedDRA10019558 Hemorrhage pulmonaryLLTMedDRA10019582 Lung haemorrhageLLTMedDRA10055862 Lung hemorrhageLLTMedDRA10025100 Pulmonary haemorrhageLLTMedDRA10037394 Pulmonary hemorrhageLLTMedDRA10037397 Bronchopulmonary hemorrhage C78224 E13346 Bronchospasm 10006482 NCIA disorder characterized by a sudden contraction of the smooth muscles of the bronchial wall. Allergic bronchospasmLLTMedDRA10064973 Bronchial spasmLLTMedDRA10006443 BronchoconstrictionLLTMedDRA10006464 Bronchospasm NOSLLTMedDRA10006485 Bronchospasm aggravatedLLTMedDRA10006483 BronchospasmLLTMedDRA10006482 BronchospasmPTCTCAE Exercise-induced bronchospasmLLTMedDRA10015655 Spasm bronchialLLTMedDRA10041378 Bronchospasm C34439 E13352 Bruising 10006504 NCIA finding of injury of the soft tissues or bone characterized by leakage of blood into surrounding tissues. Bruise of headLLTMedDRA10006503 BruiseLLTMedDRA10006502 Bruising of armLLTMedDRA10006505 Bruising of chestLLTMedDRA10006506 Bruising of faceLLTMedDRA10006507 Bruising of footLLTMedDRA10006508 Bruising of handLLTMedDRA10006509 Bruising of legLLTMedDRA10006510 Bruising of thighLLTMedDRA10006511 Bruising of trunkLLTMedDRA10006512 BruisingLLTMedDRA10006504 BruisingPTCTCAE Contusion of abdominal wallLLTMedDRA10010837 Contusion of ankleLLTMedDRA10010838 Contusion of axillary regionLLTMedDRA10010840 Contusion of backLLTMedDRA10010841 Contusion of breastLLTMedDRA10010842 Contusion of chest wallLLTMedDRA10010843 Contusion of elbowLLTMedDRA10010844 Contusion of fingerLLTMedDRA10010851 Contusion of footLLTMedDRA10010852 Contusion of forearmLLTMedDRA10010853 Contusion of hand(s)LLTMedDRA10010855 Contusion of hipLLTMedDRA10010858 Contusion of kneeLLTMedDRA10010860 Contusion of lower legLLTMedDRA10010862 Contusion of multiple sites of lower limbLLTMedDRA10010866 Contusion of multiple sites of trunkLLTMedDRA10010868 Contusion of multiple sites of upper limbLLTMedDRA10010869 Contusion of scapular regionLLTMedDRA10010872 Contusion of shoulder regionLLTMedDRA10010874 Contusion of thighLLTMedDRA10010875 Contusion of toeLLTMedDRA10010876 Contusion of trunkLLTMedDRA10010877 Contusion of unspecified part of lower limbLLTMedDRA10010878 Contusion of unspecified part of trunkLLTMedDRA10010879 Contusion of unspecified part of upper limbLLTMedDRA10010880 Contusion of unspecified siteLLTMedDRA10010881 Contusion of upper armLLTMedDRA10010882 Contusion of upper limbLLTMedDRA10010883 Contusion of wristLLTMedDRA10010884 ContusionLLTMedDRA10050584 Bruising C37921 E11666 Bullous dermatitis 10006556 NCIA disorder characterized by inflammation of the skin characterized by the presence of bullae which are filled with fluid. Bulla auricularLLTMedDRA10006552 Bulla dorsum manusLLTMedDRA10006553 Bullous dermatitisLLTMedDRA10006556 Bullous dermatitisPTCTCAE Bullous disorderLLTMedDRA10006558 Bullous eruptionLLTMedDRA10006559 Bullous lesionsLLTMedDRA10006565 Bullous rash both armsLLTMedDRA10006570 Bullous rash upper chestLLTMedDRA10006571 Bullous rashLLTMedDRA10006569 Dermatitis bullousLLTMedDRA10012441 Dermatosis bullousLLTMedDRA10012519 Erythema bullosumLLTMedDRA10015156 Rash bullousLLTMedDRA10037852 Rash vesiculo-bullousLLTMedDRA10037899 Rash vesiculobullousLLTMedDRA10037901 Vesiculo-bullous eruptionLLTMedDRA10047378 Vesiculo-bullous rashLLTMedDRA10047379 Vesiculobullous rashLLTMedDRA10047381 Bullous dermatitis C35149 E13617 Burn 10006634 NCIA finding of impaired integrity to the anatomic site of an adverse thermal reaction. Burns can be caused by exposure to chemicals, direct heat, electricity, flames and radiation. The extent of damage depends on the length and intensity of exposure and time until provision of treatment. BurnPTCTCAE Burn C34441 E11669 Buttock pain 10048677 NCIA disorder characterized by marked discomfort sensation in the buttocks. Buttock painPTCTCAE Buttock pain C78228 E12396 CD4 lymphocytes decreased 10007839 NCIA finding based on laboratory test results that indicate an decrease in levels of CD4 lymphocytes in a blood specimen. Absolute CD4 lymphocytes decreasedLLTMedDRA10065399 CD4 lymphocytes decreasedLLTMedDRA10007839 CD4 lymphocytes decreasedPTCTCAE CD4 lymphocytes lowLLTMedDRA10007840 CD4 positive lymphocyte depletionLLTMedDRA10007841 T-helper cells decreasedLLTMedDRA10042992 T-helper cells lowLLTMedDRA10048981 C78233 CD4 lymphocytes decreased E12122 CPK increased 10011268 NCIA finding based on laboratory test results that indicate an increase in levels of creatine phosphokinase in a blood specimen. Blood creatine phosphokinase increasedLLTMedDRA10005470 CK increasedLLTMedDRA10009219 CPK increaseLLTMedDRA10011267 CPK increasedLLTMedDRA10011268 CPK increasedPTCTCAE Creatine kinase highLLTMedDRA10011335 Creatine kinase increasedLLTMedDRA10011336 Creatine phosphokinase increasedLLTMedDRA10011349 Creatine phosphokinase serum increasedLLTMedDRA10056732 Phosphokinase creatine serum increasedLLTMedDRA10034937 Plasma creatine phosphokinase increasedLLTMedDRA10035269 Serum creatine phosphokinase increasedLLTMedDRA10040224 C78247 CPK increased E12132 CTCAE4 CTCAE4PTCTCAE CTCAE4 E10001 Capillary leak syndrome 10007196 NCIA disorder characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure. Acute vascular leak syndromeLLTMedDRA10068429 Capillary leak syndromeLLTMedDRA10007196 Capillary leak syndromePTCTCAE C62578 Capillary leak syndrome E13766 Carbon monoxide diffusing capacity decreased 10065906 NCIA finding based on lung function test results that indicate a decrease in the lung capacity to absorb carbon monoxide. Carbon monoxide diffusing capacity decreasedLLTMedDRA10065906 Carbon monoxide diffusing capacity decreasedPTCTCAE C78229 Carbon monoxide diffusing capacity decreased E12112 Cardiac arrest 10007515 NCIA disorder characterized by cessation of the pumping function of the heart. Arrest cardiacLLTMedDRA10003109 AsystoleLLTMedDRA10003586 AsystoliaLLTMedDRA10003587 AsystolicLLTMedDRA10003589 Cardiac arrest transientLLTMedDRA10007517 Cardiac arrestLLTMedDRA10007515 Cardiac arrestPTCTCAE Congestive cardioplegiaLLTMedDRA10010683 Heart arrestLLTMedDRA10019249 Hypoxic arrestLLTMedDRA10021145 Standstill cardiacLLTMedDRA10041914 C50479 Cardiac arrest E10101 Cardiac disorders 10007541 Cardiac disordersPTCTCAE Cardiac disorders E13848 Cardiac disorders - Other, specify Cardiac disorders - Other, specifyPTCTCAE Cardiac disorders - Other, specify E10104 Cardiac troponin I increased 10007612 NCIA laboratory test result which indicates increased levels of cardiac troponin I in a biological specimen. Cardiac troponin I increasedPTCTCAE C78230 Cardiac troponin I increased E12116 Cardiac troponin T increased 10007613 NCIA laboratory test result which indicates increased levels of cardiac troponin T in a biological specimen. Cardiac troponin T increasedPTCTCAE C78231 Cardiac troponin T increased E12119 Cataract 10007739 NCIA disorder characterized by partial or complete opacity of the crystalline lens of one or both eyes. This results in a decrease in visual acuity and eventual blindness if untreated. Bilateral cataractsLLTMedDRA10004558 Cataract (left)LLTMedDRA10007740 Cataract (right)LLTMedDRA10007741 Cataract NOS aggravatedLLTMedDRA10007758 Cataract NOSLLTMedDRA10007757 Cataract aggravatedLLTMedDRA10007742 Cataract bilateral NOSLLTMedDRA10007746 Cataract lenticularLLTMedDRA10007755 Cataract specifiedLLTMedDRA10007763 Cataract steroid-inducedLLTMedDRA10065090 Cataract unilateralLLTMedDRA10007767 Cataract unspecifiedLLTMedDRA10007768 Cataract with ocular neovascularisationLLTMedDRA10056192 Cataract with ocular neovascularizationLLTMedDRA10007769 CataractLLTMedDRA10007739 CataractPTCTCAE Cataracta complicata, unspecifiedLLTMedDRA10007770 Cataracts lenticularLLTMedDRA10007773 CataractsLLTMedDRA10007771 Hypermature cataractLLTMedDRA10020671 Incipient senile cataractLLTMedDRA10021618 Intumescent cataractLLTMedDRA10065321 Left cataractLLTMedDRA10024103 Myotonic cataractLLTMedDRA10028657 Non-senile cataract, unspecifiedLLTMedDRA10057726 PhacosclerosisLLTMedDRA10051266 Right cataractLLTMedDRA10039150 Secondary cataractLLTMedDRA10039827 Senile cataract, unspecifiedLLTMedDRA10039961 Senile cataractLLTMedDRA10039960 Tetanic cataractLLTMedDRA10043374 Unspecified cataractLLTMedDRA10045649 C26713 Cataract E10350 Catheter related infection 10007810 NCIA disorder characterized by an infectious process that arises secondary to catheter use. Catheter infectionLLTMedDRA10051387 Catheter related infectionLLTMedDRA10007810 Catheter related infectionPTCTCAE C78232 Catheter related infection E11328 Cecal hemorrhage 10065747 NCIA disorder characterized by bleeding from the cecum. Caecal haemorrhageLLTMedDRA10065758 Cecal hemorrhageLLTMedDRA10065747 Cecal hemorrhagePTCTCAE Colonic haemorrhageLLTMedDRA10009997 Colonic hemorrhageLLTMedDRA10009998 Haemorrhage colonLLTMedDRA10055802 Haemorrhage of colonLLTMedDRA10055826 Hemorrhage colonLLTMedDRA10019532 Hemorrhage of colonLLTMedDRA10019564 Large intestinal haemorrhageLLTMedDRA10052534 Large intestinal hemorrhageLLTMedDRA10055302 C78234 Cecal hemorrhage E10511 Cecal infection 10065761 NCIA disorder characterized by an infectious process involving the cecum. Caecal infectionLLTMedDRA10065751 Cecal infectionLLTMedDRA10065761 Cecal infectionPTCTCAE Enterocolitis infectiousLLTMedDRA10058838 Infectious colitisLLTMedDRA10021905 C78235 Cecal infection E11333 Central nervous system necrosis 10065784 NCIA disorder characterized by a necrotic process occurring in the brain and/or spinal cord. Central nervous system necrosisLLTMedDRA10065784 Central nervous system necrosisPTCTCAE C78236 Central nervous system necrosis E12605 Cerebrospinal fluid leakage 10008164 NCIA disorder characterized by loss of cerebrospinal fluid into the surrounding tissues. CSF leakageLLTMedDRA10011546 Cerebrospinal fluid leakageLLTMedDRA10008164 Cerebrospinal fluid leakagePTCTCAE Intracranial hypotensionLLTMedDRA10049977 Leakage of cerebrospinal fluidLLTMedDRA10024091 Low cerebrospinal fluid pressure syndromeLLTMedDRA10064923 C50487 Cerebrospinal fluid leakage E12611 Cervicitis infection 10008330 NCIA disorder characterized by an infectious process involving the uterine cervix. Cervicitis infectionPTCTCAE C78360 Cervicitis infection E11337 Cheilitis 10008417 NCIA disorder characterized by inflammation of the lip. Actinic cheilitisLLTMedDRA10056951 Angular cheilitisLLTMedDRA10002509 Angular cheilosisLLTMedDRA10058164 Angular stomatitisLLTMedDRA10002510 CheilitisLLTMedDRA10008417 CheilitisPTCTCAE Desquamative cheilitisLLTMedDRA10048813 Inflammation lipsLLTMedDRA10049345 Irritation lipsLLTMedDRA10049342 Lip rednessLLTMedDRA10024564 PerlecheLLTMedDRA10058162 Rash lipsLLTMedDRA10049340 Raw lipsLLTMedDRA10049343 Redness corner of mouthLLTMedDRA10049344 Sores lipLLTMedDRA10049351 C79545 Cheilitis E10517 Chest pain - cardiac 10008481 NCIA disorder characterized by substernal discomfort due to insufficient myocardial oxygenation. Angina attackLLTMedDRA10002377 Angina of effortLLTMedDRA10002380 Angina on exerciseLLTMedDRA10002381 Angina pectoris aggravatedLLTMedDRA10002384 Angina pectorisLLTMedDRA10002383 Angina syndromeLLTMedDRA10002387 Anginal attackLLTMedDRA10002390 Anginal discomfortLLTMedDRA10054224 Anginal painLLTMedDRA10002391 Anginal syndromeLLTMedDRA10002393 Atypical anginaLLTMedDRA10064077 Cardiac painLLTMedDRA10054231 CardialgiaLLTMedDRA10007616 Chest pain - cardiacLLTMedDRA10008481 Chest pain - cardiacPTCTCAE Effort anginaLLTMedDRA10014292 Elsner's asthmaLLTMedDRA10014492 Exercise induced anginaLLTMedDRA10015648 Heberden's anginaLLTMedDRA10019366 Ischaemic chest painLLTMedDRA10056256 Ischemic chest painLLTMedDRA10056259 Refractory angina pectorisLLTMedDRA10064262 Rougnon-Heberden diseaseLLTMedDRA10039237 Stable angina pectorisLLTMedDRA10049194 StenocardiaLLTMedDRA10041972 C51221 Chest pain - cardiac E10110 Chest wall pain 10008496 NCIA disorder characterized by marked discomfort sensation in the chest wall region. Chest tenderness ofLLTMedDRA10008491 Chest tendernessLLTMedDRA10008490 Chest wall painLLTMedDRA10008496 Chest wall painPTCTCAE Costal painLLTMedDRA10048711 Intercostal painLLTMedDRA10048693 Musculoskeletal chest painLLTMedDRA10050819 Pain lower ribsLLTMedDRA10033461 Rib painLLTMedDRA10048722 C78238 Chest wall pain E12400 Chills 10008531 NCIA disorder characterized by a sensation of cold that often marks a physiologic response to sweating after a fever. Chills worsenedLLTMedDRA10066501 ChillsLLTMedDRA10008531 ChillsPTCTCAE RigoringLLTMedDRA10039176 Rigors awakingLLTMedDRA10039178 RigorsLLTMedDRA10039177 ShiveringLLTMedDRA10040558 ShiversLLTMedDRA10040559 Teeth chatteringLLTMedDRA10043174 C35143 Chills E11074 Cholecystitis 10008612 NCIA disorder characterized by inflammation involving the gallbladder. It may be associated with the presence of gallstones. Acalculous cholecystitisLLTMedDRA10000347 Calculous cholecystitisLLTMedDRA10062750 Cholecystitis NOSLLTMedDRA10008619 CholecystitisLLTMedDRA10008612 CholecystitisPTCTCAE Gallbladder inflammationLLTMedDRA10017633 Inflammation gallbladderLLTMedDRA10021955 C34465 Cholecystitis E11184 Cholesterol high 10008661 NCIA finding based on laboratory test results that indicate higher than normal levels of cholesterol in a blood specimen. Cholesterol highPTCTCAE C37967 Cholesterol high E12127 Chronic kidney disease 10064848 NCIA disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure. Chronic kidney diseaseLLTMedDRA10064848 Chronic kidney diseasePTCTCAE Chronic renal failure worsenedLLTMedDRA10009121 Chronic renal failureLLTMedDRA10009119 Chronic renal insufficiencyLLTMedDRA10050441 End stage renal disease (ESRD)LLTMedDRA10014646 End stage renal failureLLTMedDRA10014647 Insidious renal failureLLTMedDRA10022436 Irreversible renal failureLLTMedDRA10022997 Kidney failure chronicLLTMedDRA10023420 Preterminal renal insufficiencyLLTMedDRA10065230 Renal failure chronic aggravatedLLTMedDRA10038445 Renal failure chronicLLTMedDRA10038444 C80078 Chronic kidney disease E12988 Chylothorax 10051228 NCIA disorder characterized by milky pleural effusion (abnormal collection of fluid) resulting from accumulation of lymph fluid in the pleural cavity. ChylothoraxLLTMedDRA10051228 ChylothoraxPTCTCAE C79546 Chylothorax E13358 Cognitive disturbance 10009845 NCIA disorder characterized by a conspicuous change in cognitive function. Chemo brainLLTMedDRA10066885 Cognitive deteriorationLLTMedDRA10009843 Cognitive disorderLLTMedDRA10057668 Cognitive disordersLLTMedDRA10048598 Cognitive disturbanceLLTMedDRA10009845 Cognitive disturbancePTCTCAE Cognitive function abnormalLLTMedDRA10048599 Cognitive impairmentLLTMedDRA10009846 C27101 Cognitive disturbance E12617 Colitis 10009887 NCIA disorder characterized by inflammation of the colon. Colitis (NOS)LLTMedDRA10009889 Colitis NOSLLTMedDRA10009898 Colitis aggravatedLLTMedDRA10009890 Colitis idiopathicLLTMedDRA10009894 ColitisLLTMedDRA10009887 ColitisPTCTCAE Distal colitisLLTMedDRA10013473 Idiopathic colitisLLTMedDRA10021220 Lymphocytic colitisLLTMedDRA10025268 PancolitisLLTMedDRA10033573 Right-sided colitisLLTMedDRA10039165 C26723 Colitis E10521 Colonic fistula 10009995 NCIA disorder characterized by an abnormal communication between the large intestine and another organ or anatomic site. Colonic fistulaLLTMedDRA10009995 Colonic fistulaPTCTCAE C78239 Colonic fistula E10527 Colonic hemorrhage 10009998 NCIA disorder characterized by bleeding from the colon. Caecal haemorrhageLLTMedDRA10065758 Cecal hemorrhageLLTMedDRA10065747 Colonic haemorrhageLLTMedDRA10009997 Colonic hemorrhageLLTMedDRA10009998 Colonic hemorrhagePTCTCAE Haemorrhage colonLLTMedDRA10055802 Haemorrhage of colonLLTMedDRA10055826 Hemorrhage colonLLTMedDRA10019532 Hemorrhage of colonLLTMedDRA10019564 Large intestinal haemorrhageLLTMedDRA10052534 Large intestinal hemorrhageLLTMedDRA10055302 C78240 Colonic hemorrhage E10533 Colonic obstruction 10010000 NCIA disorder characterized by blockage of the normal flow of the intestinal contents in the colon. Caecal obstructionLLTMedDRA10065736 Cecal obstructionLLTMedDRA10065723 Colon obstructionLLTMedDRA10009975 Colonic obstructionLLTMedDRA10010000 Colonic obstructionPTCTCAE Obstruction colonLLTMedDRA10029954 C78241 Colonic obstruction E10539 Colonic perforation 10010001 NCIA disorder characterized by a rupture in the colonic wall. Caecum perforationLLTMedDRA10049873 Caecum ruptureLLTMedDRA10049881 Cecum perforationLLTMedDRA10055432 Cecum ruptureLLTMedDRA10055433 Colon perforationLLTMedDRA10009977 Colonic perforation postoperativeLLTMedDRA10010002 Colonic perforationLLTMedDRA10010001 Colonic perforationPTCTCAE Iatrogenic colon perforationLLTMedDRA10021174 Intestinal perforation largeLLTMedDRA10022695 Large bowel perforationLLTMedDRA10023712 Large intestinal perforation NOSLLTMedDRA10023795 Large intestinal ulcer perforationLLTMedDRA10052497 Large intestine perforationLLTMedDRA10023804 Perforated colonLLTMedDRA10034386 Perforated large intestineLLTMedDRA10034395 Perforation colonLLTMedDRA10034407 Perforation during colonoscopyLLTMedDRA10066433 Perforation large intestineLLTMedDRA10034415 Perforation of colonLLTMedDRA10034418 Perforation post barium enemaLLTMedDRA10034427 Perforation post colonoscopyLLTMedDRA10034428 Ruptured diverticulum of colonLLTMedDRA10039331 C78242 Colonic perforation E10545 Colonic stenosis 10010004 NCIA disorder characterized by a narrowing of the lumen of the colon. Colon stenosisLLTMedDRA10009981 Colonic stenosisLLTMedDRA10010004 Colonic stenosisPTCTCAE Colonic strictureLLTMedDRA10010005 Stenosis colonLLTMedDRA10041977 Stenosis of colonLLTMedDRA10041983 Stricture of colonLLTMedDRA10042234 C78243 Colonic stenosis E10550 Colonic ulcer 10010006 NCIA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the colon. Caecal ulcerLLTMedDRA10065964 Cecal ulcerLLTMedDRA10065724 Colon ulcerLLTMedDRA10009983 Colonic ulcerLLTMedDRA10010006 Colonic ulcerPTCTCAE Intestinal large ulcerLLTMedDRA10022682 Large bowel ulcerLLTMedDRA10023714 Large intestinal ulcerLLTMedDRA10023799 Large intestine ulcerLLTMedDRA10023805 Ulcer colonLLTMedDRA10045293 Ulcer large intestineLLTMedDRA10045316 C78244 Colonic ulcer E10556 Concentration impairment 10010250 NCIA disorder characterized by a deterioration in the ability to concentrate. Attention concentration difficultyLLTMedDRA10003729 Attention impairedLLTMedDRA10003738 Attentiveness decreasedLLTMedDRA10003740 Concentration (mental) abnormalLLTMedDRA10010247 Concentration ability impairedLLTMedDRA10010248 Concentration impairedLLTMedDRA10010249 Concentration impairmentLLTMedDRA10010250 Concentration impairmentPTCTCAE Concentration lossLLTMedDRA10010251 Disturbance in attentionLLTMedDRA10013496 Impairment of attentionLLTMedDRA10021525 Mental concentration decreasedLLTMedDRA10027346 Mental concentration difficultLLTMedDRA10027347 Mental concentration difficultyLLTMedDRA10027348 Mental concentration impairedLLTMedDRA10027349 Poor concentrationLLTMedDRA10036149 Simple disturbance of activity and attentionLLTMedDRA10040698 Vigilance decreasedLLTMedDRA10050400 C80081 Concentration impairment E12621 Conduction disorder 10010276 NCIA disorder characterized by pathological irregularities in the cardiac conduction system. Conduction disorder NOSLLTMedDRA10010277 Conduction disorder, unspecifiedLLTMedDRA10010278 Conduction disorderLLTMedDRA10010276 Conduction disorderPTCTCAE Conduction disordersLLTMedDRA10010279 Defect conduction intraventricularLLTMedDRA10012118 Heart block intraventricularLLTMedDRA10019266 Intraventricular blockLLTMedDRA10022839 C78245 Conduction disorder E10114 Confusion 10010300 NCIA disorder characterized by a lack of clear and orderly thought and behavior. Acute confusion stateLLTMedDRA10000693 Acute confusional stateLLTMedDRA10000694 Acute onset of confusionLLTMedDRA10000954 BewildermentLLTMedDRA10004541 ConfusedLLTMedDRA10010298 Confusion aggravatedLLTMedDRA10048321 Confusion nocturnalLLTMedDRA10010302 Confusion reversibleLLTMedDRA10010303 Confusion stateLLTMedDRA10010304 ConfusionLLTMedDRA10010300 ConfusionPTCTCAE Confusional stateLLTMedDRA10010305 Mental confusionLLTMedDRA10027350 Nocturnal confusionLLTMedDRA10029449 Reactive confusionLLTMedDRA10037997 Subacute confusional stateLLTMedDRA10042274 Toxic confusional stateLLTMedDRA10044136 C37928 Confusion E12889 Congenital, familial and genetic disorders 10010331 Congenital, familial and genetic disordersPTCTCAE Congenital, familial and genetic disorders E13862 Congenital, familial and genetic disorders - Other, specify Congenital, familial and genetic disorders - Other, specifyPTCTCAE Congenital, familial and genetic disorders - Other, specify E10250 Conjunctivitis 10010741 NCIA disorder characterized by inflammation, swelling and redness to the conjunctiva of the eye. Acute conjunctivitis, unspecifiedLLTMedDRA10000696 Acute conjunctivitisLLTMedDRA10000695 Acute follicular conjunctivitisLLTMedDRA10000749 Angular blepharoconjunctivitisLLTMedDRA10002508 Blepharo conjunctivitisLLTMedDRA10005151 Blepharoconjunctivitis, unspecifiedLLTMedDRA10005154 BlepharoconjunctivitisLLTMedDRA10005153 Chronic conjunctivitis, unspecifiedLLTMedDRA10008850 Chronic conjunctivitisLLTMedDRA10008849 Chronic follicular conjunctivitisLLTMedDRA10008876 Conjunctival dischargeLLTMedDRA10052121 Conjunctivitis NOSLLTMedDRA10010751 Conjunctivitis aggravatedLLTMedDRA10010743 Conjunctivitis chronicLLTMedDRA10010746 Conjunctivitis exacerbatedLLTMedDRA10010748 Conjunctivitis in mucocutaneous diseaseLLTMedDRA10010750 Conjunctivitis necroticLLTMedDRA10010752 Conjunctivitis papillaryLLTMedDRA10010753 Conjunctivitis, unspecifiedLLTMedDRA10010757 ConjunctivitisLLTMedDRA10010741 ConjunctivitisPTCTCAE Discharge conjunctivitisLLTMedDRA10013066 Florid follicular conjunctivitisLLTMedDRA10016787 Follicular conjunctivitisLLTMedDRA10052151 Pseudomembranous conjunctivitisLLTMedDRA10037129 RhinoconjunctivitisLLTMedDRA10039097 Rosacea conjunctivitisLLTMedDRA10039220 Serous conjunctivitis, except viralLLTMedDRA10040110 Serous conjunctivitis, excl viralLLTMedDRA10056802 Simple chronic conjunctivitisLLTMedDRA10040684 Toxic conjunctivitisLLTMedDRA10063622 C34504 Conjunctivitis E10355 Conjunctivitis infective 10010742 NCIA disorder characterized by an infectious process involving the conjunctiva. Clinical manifestations include pink or red color in the eyes. Conjunctivitis infectiveLLTMedDRA10010742 Conjunctivitis infectivePTCTCAE Parasitic conjunctivitisLLTMedDRA10033911 PinkeyeLLTMedDRA10059861 Purulent conjunctivitisLLTMedDRA10037568 C35704 Conjunctivitis infective E11342 Constipation 10010774 NCIA disorder characterized by irregular and infrequent or difficult evacuation of the bowels. Constipation (excl faecal impaction)LLTMedDRA10010775 Constipation (excl fecal impaction)LLTMedDRA10055500 Constipation aggravatedLLTMedDRA10048346 Constipation chronicLLTMedDRA10063582 ConstipationLLTMedDRA10010774 ConstipationPTCTCAE Iatrogenic constipationLLTMedDRA10021175 ObstipationLLTMedDRA10029932 Stools absentLLTMedDRA10059082 C37930 Constipation E10562 Constrictive pericarditis 10010783 NCIA disorder characterized by a thickened and fibrotic pericardial sac; these fibrotic changes impede normal myocardial function by restricting myocardial muscle action. Chronic pericardial constrictionLLTMedDRA10009100 Constrictive pericarditisLLTMedDRA10010783 Constrictive pericarditisPTCTCAE Pericarditis constrictiveLLTMedDRA10034487 C78246 Constrictive pericarditis E10120 Corneal infection 10061788 NCIA disorder characterized by an infectious process involving the cornea. Corneal infection NOSLLTMedDRA10011020 Corneal infectionLLTMedDRA10061788 Corneal infectionPTCTCAE C26805 Corneal infection E11347 Corneal ulcer 10048492 NCIA disorder characterized by an area of epithelial tissue loss on the surface of the cornea. It is associated with inflammatory cells in the cornea and anterior chamber. Central corneal ulcerLLTMedDRA10007929 Corneal meltLLTMedDRA10059795 Corneal ulcer marginalLLTMedDRA10011057 Corneal ulcer, unspecifiedLLTMedDRA10011059 Corneal ulcerLLTMedDRA10048492 Corneal ulcerPTCTCAE Corneal ulcerationLLTMedDRA10011060 Mooren's ulcerLLTMedDRA10027955 Necrosis cornealLLTMedDRA10028858 Perforated corneal ulcerLLTMedDRA10034387 Ring corneal ulcerLLTMedDRA10039181 Ulcer corneal perforatedLLTMedDRA10045296 Ulcer cornealLLTMedDRA10045295 Ulcerative keratitisLLTMedDRA10064996 C50515 Corneal ulcer E10359 Cough 10011224 NCIA disorder characterized by sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs and usually accompanied by a distinctive sound. Acute coughLLTMedDRA10066522 Chronic coughLLTMedDRA10066656 Cough aggravatedLLTMedDRA10048381 Cough increasedLLTMedDRA10011228 Cough nonproductiveLLTMedDRA10011229 Cough resembling asthmaLLTMedDRA10011230 CoughLLTMedDRA10011224 CoughPTCTCAE Coughing after drug inhalationLLTMedDRA10054919 CoughingLLTMedDRA10011232 Drug-induced coughLLTMedDRA10058276 Dry coughLLTMedDRA10013773 Irritant coughLLTMedDRA10023011 Irritative coughLLTMedDRA10023018 Nocturnal coughLLTMedDRA10029450 Paroxysmal coughLLTMedDRA10066222 Persistent dry coughLLTMedDRA10034707 Persistent non-productive coughLLTMedDRA10034712 Smoker's coughLLTMedDRA10059666 C37935 Cough E13364 Cranial nerve infection 10065765 NCIA disorder characterized by an infectious process involving a cranial nerve. Cranial nerve infectionLLTMedDRA10065765 Cranial nerve infectionPTCTCAE C78248 Cranial nerve infection E11352 Creatinine increased 10011368 NCIA finding based on laboratory test results that indicate increased levels of creatinine in a biological specimen. Blood creatinine increasedLLTMedDRA10005483 Creatinine blood increasedLLTMedDRA10011361 Creatinine highLLTMedDRA10011367 Creatinine increasedLLTMedDRA10011368 Creatinine increasedPTCTCAE Creatinine serum increasedLLTMedDRA10011375 Increased serum creatinineLLTMedDRA10021678 Plasma creatinine increasedLLTMedDRA10035278 Raised serum creatinineLLTMedDRA10037825 Serum creatinine increasedLLTMedDRA10040233 C78249 Creatinine increased E12137 Cushingoid 10011655 NCIA disorder characterized by signs and symptoms that resemble Cushing's disease or syndrome: buffalo hump obesity, striations, adiposity, hypertension, diabetes, and osteoporosis, usually due to exogenous corticosteroids. Cushing-like buildLLTMedDRA10011654 Cushingoid faciesLLTMedDRA10011656 CushingoidLLTMedDRA10011655 CushingoidPTCTCAE Moon faceLLTMedDRA10027953 C37938 Cushingoid E10304 Cystitis noninfective 10063057 NCIA disorder characterized by inflammation of the bladder which is not caused by an infection of the urinary tract. Bladder inflammationLLTMedDRA10063059 Chronic cystitisLLTMedDRA10008852 Cystitis chronic NOSLLTMedDRA10011787 Cystitis chronicLLTMedDRA10011786 Cystitis granulomatousLLTMedDRA10062272 Cystitis noninfectiveLLTMedDRA10063057 Cystitis noninfectivePTCTCAE C78250 Cystitis noninfective E12994 Cytokine release syndrome 10052015 NCIA disorder characterized by nausea, headache, tachycardia, hypotension, rash, and shortness of breath; it is caused by the release of cytokines from the cells. Cytokine release syndromeLLTMedDRA10052015 Cytokine release syndromePTCTCAE C78251 Cytokine release syndrome E11264 Death NOS 10011914 NCIA cessation of life that cannot be attributed to a CTCAE term associated with Grade 5. Death NOSPTCTCAE C28554 Death NOS E11080 Death neonatal 10011912 NCIA disorder characterized by cessation of life occurring during the first 28 days of life. Death neonatalLLTMedDRA10011912 Death neonatalPTCTCAE C80082 Death neonatal E11078 Dehydration 10012174 NCIA disorder characterized by excessive loss of water from the body. It is usually caused by severe diarrhea, vomiting or diaphoresis. DehydrationLLTMedDRA10012174 DehydrationPTCTCAE ExsiccosisLLTMedDRA10054198 Fluid lossLLTMedDRA10016802 Hypertonic dehydrationLLTMedDRA10057218 Hypotonic dehydrationLLTMedDRA10021120 Isotonic dehydrationLLTMedDRA10057215 Water excessive loss ofLLTMedDRA10047836 C26740 Dehydration E12258 Delayed orgasm 10057066 NCIA disorder characterized by sexual dysfunction characterized by a delay in climax. Delayed orgasmLLTMedDRA10057066 Delayed orgasmPTCTCAE Orgasm abnormalLLTMedDRA10031085 Painful orgasmLLTMedDRA10059404 C78252 Delayed orgasm E12895 Delayed puberty 10012205 NCIA disorder characterized by unusually late sexual maturity. Delayed pubertyLLTMedDRA10012205 Delayed pubertyPTCTCAE C62587 Delayed puberty E10308 Delirium 10012218 NCIA disorder characterized by the acute and sudden development of confusion, illusions, movement changes, inattentiveness, agitation, and hallucinations. Usually, it is a reversible condition. Acute brain syndromeLLTMedDRA10000685 Acute deliriumLLTMedDRA10000702 Brain syndrome acuteLLTMedDRA10006150 DeliriousLLTMedDRA10012217 Delirium due to a general medical conditionLLTMedDRA10012220 Delirium nocturnalLLTMedDRA10012223 Delirium toxicLLTMedDRA10012224 Delirium, cause unknownLLTMedDRA10012226 DeliriumLLTMedDRA10012218 DeliriumPTCTCAE Disorder brain (acute)LLTMedDRA10013195 Drug-induced deliriumLLTMedDRA10013758 Sensory deprivation deliriumLLTMedDRA10040024 Subacute deliriumLLTMedDRA10042275 SundowningLLTMedDRA10058915 Syndrome brain acuteLLTMedDRA10042790 C2981 Delirium E12898 Delusions 10012260 NCIA disorder characterized by false personal beliefs held contrary to reality, despite contradictory evidence and common sense. DeludedLLTMedDRA10012238 Delusion NOSLLTMedDRA10012240 Delusion of selfaccusationLLTMedDRA10012246 Delusion unsystematizedLLTMedDRA10012248 DelusionLLTMedDRA10012239 DelusionsLLTMedDRA10012260 DelusionsPTCTCAE Drug-induced organic delusional syndromeLLTMedDRA10013764 Nocturnal psychotic delusionsLLTMedDRA10029457 Organic delusional syndromeLLTMedDRA10031078 Paranoid delusionsLLTMedDRA10033867 C26741 Delusions E12904 Dental caries 10012318 NCIA disorder characterized by the decay of a tooth, in which it becomes softened, discolored and/or porous. Dental cariesPTCTCAE C52593 Dental caries E10568 Depressed level of consciousness 10012373 NCIA disorder characterized by a decrease in ability to perceive and respond. Alertness decreasedLLTMedDRA10049875 Arousal difficultLLTMedDRA10003104 CNS depression NOSLLTMedDRA10009711 CNS depressionLLTMedDRA10009710 Central nervous system depression NOSLLTMedDRA10007941 Consciousness abnormalLLTMedDRA10010765 Consciousness cloudingLLTMedDRA10010767 Consciousness decreasedLLTMedDRA10010768 Depressed level of consciousnessLLTMedDRA10012373 Depressed level of consciousnessPTCTCAE Depression central nervous systemLLTMedDRA10012383 ObnubilationLLTMedDRA10049219 Obtundation mentalLLTMedDRA10029986 ObtundationLLTMedDRA10029985 PrecomaLLTMedDRA10058705 Semi-comaLLTMedDRA10039950 Semi-consciousLLTMedDRA10039951 Sensorium decreasedLLTMedDRA10040019 Slow response to stimuliLLTMedDRA10041045 Unconscious partialLLTMedDRA10045480 C78253 Depressed level of consciousness E12625 Depression 10012378 NCIA disorder characterized by melancholic feelings of grief or unhappiness. Acute depressionLLTMedDRA10066530 Anxiety depressionLLTMedDRA10002858 Anxiodepressive syndromeLLTMedDRA10066933 Anxious depressionLLTMedDRA10002873 Atypical depressive disorderLLTMedDRA10003748 Brief depressive reactionLLTMedDRA10006358 Chronic depressionLLTMedDRA10066555 Depressed reactionLLTMedDRA10012376 Depressed stateLLTMedDRA10012377 Depression NOSLLTMedDRA10012387 Depression aggravatedLLTMedDRA10012379 Depression functionalLLTMedDRA10012385 Depression mentalLLTMedDRA10012386 Depression reactiveLLTMedDRA10012395 Depression worsenedLLTMedDRA10012398 DepressionLLTMedDRA10012378 DepressionPTCTCAE Depressive disorderLLTMedDRA10012399 Depressive episodeLLTMedDRA10012402 Depressive illnessLLTMedDRA10012403 Depressive reactionLLTMedDRA10012406 Depressive stateLLTMedDRA10049709 Depressive stuporLLTMedDRA10012407 Exogenous depressionLLTMedDRA10015675 Mixed anxiety & depressiveLLTMedDRA10027741 Reactive depressionLLTMedDRA10037998 Recurrent depressive disorderLLTMedDRA10066589 Unipolar depressionLLTMedDRA10045543 Unipolar depressive illnessLLTMedDRA10045544 C2982 Depression E12909 Dermatitis radiation 10061103 NCIA finding of cutaneous inflammatory reaction occurring as a result of exposure to biologically effective levels of ionizing radiation. Dermatitis radiation NOSLLTMedDRA10012487 Dermatitis radiationLLTMedDRA10061103 Dermatitis radiationPTCTCAE Radiation burnLLTMedDRA10063640 Radiation skin injuryLLTMedDRA10063562 Radiation skin sensitivityLLTMedDRA10037769 C3349 Dermatitis radiation E11675 Device related infection 10064687 NCIA disorder characterized by an infectious process involving the use of a medical device. Device related infectionLLTMedDRA10064687 Device related infectionPTCTCAE Implant infectionLLTMedDRA10021540 Prosthesis related infectionLLTMedDRA10065011 Vascular implant infectionLLTMedDRA10057561 C79705 Device related infection E11356 Diarrhea 10012727 NCIA disorder characterized by frequent and watery bowel movements. Acute diarrheaLLTMedDRA10000706 Acute diarrhoeaLLTMedDRA10055955 Antibiotic-associated diarrheaLLTMedDRA10002739 Antibiotic-associated diarrhoeaLLTMedDRA10055956 Chronic diarrheaLLTMedDRA10066556 Chronic diarrhoeaLLTMedDRA10066557 Diarrhea NOSLLTMedDRA10012732 Diarrhea aggravatedLLTMedDRA10012728 Diarrhea functional (due to spastic colon)LLTMedDRA10055410 Diarrhea post chemotherapyLLTMedDRA10057013 Diarrhea recurrentLLTMedDRA10066533 DiarrheaLLTMedDRA10012727 DiarrheaPTCTCAE Diarrhoea NOSLLTMedDRA10012745 Diarrhoea aggravatedLLTMedDRA10012737 Diarrhoea functional (due to spastic colon)LLTMedDRA10012740 Diarrhoea post chemotherapyLLTMedDRA10056985 Diarrhoea recurrentLLTMedDRA10066534 DiarrhoeaLLTMedDRA10012735 Explosive diarrheaLLTMedDRA10055414 Explosive diarrhoeaLLTMedDRA10015704 Frank diarrheaLLTMedDRA10055415 Frank diarrhoeaLLTMedDRA10017331 Functional diarrhea (due to spastic colon)LLTMedDRA10055416 Functional diarrheaLLTMedDRA10017495 Functional diarrhoea (due to spastic colon)LLTMedDRA10017497 Functional diarrhoeaLLTMedDRA10017496 Iatrogenic diarrheaLLTMedDRA10021176 Iatrogenic diarrhoeaLLTMedDRA10021177 Idiopathic diarrheaLLTMedDRA10021223 Idiopathic diarrhoeaLLTMedDRA10055958 Loose bowelLLTMedDRA10024837 Loose bowelsLLTMedDRA10024838 Loose motionsLLTMedDRA10024839 Loose stoolsLLTMedDRA10024840 Mucous diarrheaLLTMedDRA10056241 Mucous diarrhoeaLLTMedDRA10056240 Mushy diarrheaLLTMedDRA10067054 Mushy diarrhoeaLLTMedDRA10067053 Mushy stoolLLTMedDRA10028399 Nocturnal diarrheaLLTMedDRA10029451 Nocturnal diarrhoeaLLTMedDRA10055959 Osmotic diarrheaLLTMedDRA10057036 Paradoxical diarrheaLLTMedDRA10068684 Paradoxical diarrhoeaLLTMedDRA10068685 Secretory diarrheaLLTMedDRA10039894 Secretory diarrhoeaLLTMedDRA10055960 Soft stoolsLLTMedDRA10048838 Stools looseLLTMedDRA10042156 Stools wateryLLTMedDRA10042157 Urgent diarrheaLLTMedDRA10055420 Urgent diarrhoeaLLTMedDRA10046498 Watery diarrheaLLTMedDRA10055422 Watery diarrhoeaLLTMedDRA10047849 C2987 Diarrhea E10572 Disseminated intravascular coagulation 10013442 NCIA disorder characterized by systemic pathological activation of blood clotting mechanisms which results in clot formation throughout the body. There is an increase in the risk of hemorrhage as the body is depleted of platelets and coagulation factors. Consumption coagulopathyLLTMedDRA10010785 Consumptive coagulopathyLLTMedDRA10010786 Consumptive thrombohaemorrhagic syndromeLLTMedDRA10067048 Consumptive thrombohemorrhagic syndromeLLTMedDRA10067052 DICLLTMedDRA10012769 Defibrination syndromeLLTMedDRA10012126 Dissem. intravasc. coagulationLLTMedDRA10013429 Disseminated intravascular coagulationLLTMedDRA10013442 Disseminated intravascular coagulationPTCTCAE Systemic hypercoagulative disorderLLTMedDRA10042942 C2992 Disseminated intravascular coagulation E10028 Dizziness 10013573 NCIA disorder characterized by a disturbing sensation of lightheadedness, unsteadiness, giddiness, spinning or rocking. Dizziness aggravatedLLTMedDRA10048324 DizzinessLLTMedDRA10013573 DizzinessPTCTCAE Dizzy spellsLLTMedDRA10013582 DizzyLLTMedDRA10013580 Felt faintLLTMedDRA10016379 Felt giddyLLTMedDRA10016381 GiddinessLLTMedDRA10018263 Light headednessLLTMedDRA10024461 Light-headed feelingLLTMedDRA10024491 Light-headedLLTMedDRA10024490 LightheadednessLLTMedDRA10024492 Swaying feelingLLTMedDRA10042651 WoozinessLLTMedDRA10048018 WoozyLLTMedDRA10048019 C37943 Dizziness E12631 Dry eye 10013774 NCIA disorder characterized by dryness of the cornea and conjunctiva. Dry eye NOSLLTMedDRA10013775 Dry eyeLLTMedDRA10013774 Dry eyePTCTCAE Dry eyes aggravatedLLTMedDRA10048422 Dry eyesLLTMedDRA10013778 Dryness of eyesLLTMedDRA10013792 Eye drynessLLTMedDRA10015921 Eyes dryLLTMedDRA10016004 C34553 Dry eye E10363 Dry mouth 10013781 NCIA disorder characterized by reduced salivary flow in the oral cavity. Dry mouthLLTMedDRA10013781 Dry mouthPTCTCAE Dryness oralLLTMedDRA10013794 Gingival drynessLLTMedDRA10054868 Mouth became dryLLTMedDRA10028016 Mouth dry aggravatedLLTMedDRA10048350 Mouth dryLLTMedDRA10028021 Mouth feeling dryLLTMedDRA10028022 Mouth puckeredLLTMedDRA10049332 Oral drynessLLTMedDRA10030974 XerostomiaLLTMedDRA10048223 C26917 Dry mouth E10578 Dry skin 10013786 NCIA disorder characterized by flaky and dull skin; the pores are generally fine, the texture is a papery thin texture. Dry scalpLLTMedDRA10059295 Dry skin aggravatedLLTMedDRA10066535 Dry skinLLTMedDRA10013786 Dry skinPTCTCAE Hot dry skinLLTMedDRA10020403 Rough facial skinLLTMedDRA10039235 Skin dryLLTMedDRA10040835 Skin roughLLTMedDRA10040917 Skin roughnessLLTMedDRA10040918 Skin xerosisLLTMedDRA10064130 C74592 Dry skin E13623 Duodenal fistula 10013828 NCIA disorder characterized by an abnormal communication between the duodenum and another organ or anatomic site. Duodenal fistulaLLTMedDRA10013828 Duodenal fistulaPTCTCAE C78256 Duodenal fistula E10582 Duodenal hemorrhage 10055242 NCIA disorder characterized by bleeding from the duodenum. Duodenal bleedingLLTMedDRA10013814 Duodenal haemorrhageLLTMedDRA10013829 Duodenal hemorrhageLLTMedDRA10055242 Duodenal hemorrhagePTCTCAE Haemorrhage duodenumLLTMedDRA10055804 Haemorrhage ileumLLTMedDRA10055812 Haemorrhage jejunumLLTMedDRA10055819 Haemorrhage of ileumLLTMedDRA10055828 Haemorrhage of jejunumLLTMedDRA10055829 Hemorrhage duodenumLLTMedDRA10019534 Hemorrhage ileumLLTMedDRA10019546 Hemorrhage jejunumLLTMedDRA10019556 Hemorrhage of ileumLLTMedDRA10019567 Hemorrhage of jejunumLLTMedDRA10019568 Ileal haemorrhageLLTMedDRA10021301 Ileal hemorrhageLLTMedDRA10055287 Jejunal haemorrhageLLTMedDRA10023173 Jejunal hemorrhageLLTMedDRA10055300 Small intestinal haemorrhageLLTMedDRA10052535 Small intestinal hemorrhageLLTMedDRA10055337 C78257 Duodenal hemorrhage E10588 Duodenal infection 10065752 NCIA disorder characterized by an infectious process involving the duodenum. Duodenal infectionLLTMedDRA10065752 Duodenal infectionPTCTCAE Enteritis infectiousLLTMedDRA10058839 Ileal infectionLLTMedDRA10065753 Ill-defined intestinal infectionsLLTMedDRA10021354 Jejunal infectionLLTMedDRA10065754 Small intestine infectionLLTMedDRA10065771 C78258 Duodenal infection E11360 Duodenal obstruction 10013830 NCIA disorder characterized by blockage of the normal flow of stomach contents through the duodenum. Duodenal obstructionLLTMedDRA10013830 Duodenal obstructionPTCTCAE Obstruction duodenalLLTMedDRA10029955 C79548 Duodenal obstruction E10594 Duodenal perforation 10013832 NCIA disorder characterized by a rupture in the duodenal wall. Duodenal perforationLLTMedDRA10013832 Duodenal perforationPTCTCAE Perforation duodenalLLTMedDRA10034409 C78259 Duodenal perforation E10600 Duodenal stenosis 10050094 NCIA disorder characterized by a narrowing of the lumen of the duodenum. Duodenal membranous stenosisLLTMedDRA10059727 Duodenal stenosisLLTMedDRA10050094 Duodenal stenosisPTCTCAE Duodenal stricture acquiredLLTMedDRA10013835 Duodenal strictureLLTMedDRA10013834 C78260 Duodenal stenosis E10605 Duodenal ulcer 10013836 NCIA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the duodenal wall. Acute duodenal ulcer without mention of haemorrhage or perforationLLTMedDRA10000723 Acute duodenal ulcer without mention of hemorrhage or perforationLLTMedDRA10000724 Acute duodenal ulcerLLTMedDRA10000711 Chronic duodenal ulcer without mention of haemorrhage or perforationLLTMedDRA10008860 Chronic duodenal ulcer without mention of hemorrhage or perforationLLTMedDRA10008861 DULLTMedDRA10013797 Duodenal ulcer aggravatedLLTMedDRA10013838 Duodenal ulcer reactivatedLLTMedDRA10013851 Duodenal ulcerLLTMedDRA10013836 Duodenal ulcerPTCTCAE Reactivated DULLTMedDRA10037986 Reactivated duodenal ulcerLLTMedDRA10037987 Ulcer duodenal reactivatedLLTMedDRA10045299 Ulcer duodenalLLTMedDRA10045297 C26755 Duodenal ulcer E10611 Dysarthria 10013887 NCIA disorder characterized by slow and slurred speech resulting from an inability to coordinate the muscles used in speech. Articulation problemLLTMedDRA10065167 DysarthriaLLTMedDRA10013887 DysarthriaPTCTCAE InarticulatenessLLTMedDRA10021599 Slurred speechLLTMedDRA10041053 Speech slurredLLTMedDRA10041472 C79549 Dysarthria E12635 Dysesthesia 10062872 NCIA disorder characterized by distortion of sensory perception, resulting in an abnormal and unpleasant sensation. Cheiro-oral syndromeLLTMedDRA10064576 Dysaesthesia extremityLLTMedDRA10062820 Dysaesthesia thighLLTMedDRA10062823 DysaesthesiaLLTMedDRA10013886 Dysesthesia extremityLLTMedDRA10049919 Dysesthesia thighLLTMedDRA10049911 DysesthesiaLLTMedDRA10062872 DysesthesiaPTCTCAE C28246 Dysesthesia E12639 Dysgeusia 10013911 NCIA disorder characterized by abnormal sensual experience with the taste of foodstuffs; it can be related to a decrease in the sense of smell. After tasteLLTMedDRA10001464 Bilious tasteLLTMedDRA10049849 DysgeusiaLLTMedDRA10013911 DysgeusiaPTCTCAE ParageusiaLLTMedDRA10033793 Taste abnormalityLLTMedDRA10043123 Taste alterationLLTMedDRA10043125 Taste alteredLLTMedDRA10043126 Taste bitter-saltyLLTMedDRA10043128 Taste bitterLLTMedDRA10043127 Taste changedLLTMedDRA10043129 Taste disturbanceLLTMedDRA10043132 Taste garlicLLTMedDRA10043133 Taste metallicLLTMedDRA10043135 Taste peculiarLLTMedDRA10043136 Taste perversionLLTMedDRA10043137 Taste saltyLLTMedDRA10043139 Taste sourLLTMedDRA10043140 Taste sweetLLTMedDRA10043141 C28145 Dysgeusia E12643 Dysmenorrhea 10013934 NCIA disorder characterized by abnormally painful abdominal cramps during menses. DysmenorrheaPTCTCAE C34559 Dysmenorrhea E13077 Dyspareunia 10013941 NCIA disorder characterized by painful or difficult coitus. Coitus painfulLLTMedDRA10009850 Deep dyspareuniaLLTMedDRA10011990 Dyspareunia (female excl psychogenic)LLTMedDRA10013942 Dyspareunia (male excl psychogenic)LLTMedDRA10013943 Dyspareunia NOSLLTMedDRA10013944 Dyspareunia psychogenicLLTMedDRA10013945 DyspareuniaLLTMedDRA10013941 DyspareuniaPTCTCAE Painful intercourseLLTMedDRA10033510 Post coital painLLTMedDRA10067031 Psychogenic dyspareuniaLLTMedDRA10037193 Superficial dyspareuniaLLTMedDRA10042505 C2997 Dyspareunia E13081 Dyspepsia 10013946 NCIA disorder characterized by an uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach, bloating, heartburn, nausea and vomiting. Acid dyspepsiaLLTMedDRA10000460 Acid indigestionLLTMedDRA10000464 Chronic heartburnLLTMedDRA10066567 Difficult digestionLLTMedDRA10012790 Digestion impairedLLTMedDRA10012980 Distress epigastricLLTMedDRA10013490 Dyspepsia aggravatedLLTMedDRA10013947 DyspepsiaLLTMedDRA10013946 DyspepsiaPTCTCAE Epigastric burningLLTMedDRA10015015 Epigastric distressLLTMedDRA10015016 Epigastric food-related painLLTMedDRA10015017 Flatulent dyspepsiaLLTMedDRA10016768 Functional dyspepsiaLLTMedDRA10064536 Gastroesophageal burningLLTMedDRA10066998 Gastrooesophageal burningLLTMedDRA10066990 Heartburn aggravatedLLTMedDRA10019327 Heartburn-like dyspepsiaLLTMedDRA10019328 HeartburnLLTMedDRA10019326 Increasing indigestionLLTMedDRA10021697 Indigestion acidLLTMedDRA10021707 Indigestion nervousLLTMedDRA10021708 IndigestionLLTMedDRA10021706 MaldigestionLLTMedDRA10049602 Non-ulcer dyspepsiaLLTMedDRA10065005 PyrosisLLTMedDRA10037676 Retrosternal burningLLTMedDRA10038985 Stomach burning sensation ofLLTMedDRA10042079 Ulcer-like dyspepsiaLLTMedDRA10045344 WaterbrashLLTMedDRA10047844 C26756 Dyspepsia E10617 Dysphagia 10013950 NCIA disorder characterized by difficulty in swallowing. Deglutition disorderLLTMedDRA10012173 Disorder deglutitionLLTMedDRA10013213 Dysphagia aggravatedLLTMedDRA10048359 DysphagiaLLTMedDRA10013950 DysphagiaPTCTCAE Swallowing difficultLLTMedDRA10042645 Swallowing disorderLLTMedDRA10042646 Swallowing impairedLLTMedDRA10042647 Swallowing spasmLLTMedDRA10042649 C2980 Dysphagia E10621 Dysphasia 10013951 NCIA disorder characterized by impairment of verbal communication skills, often resulting from brain damage. DysphasiaLLTMedDRA10013951 DysphasiaPTCTCAE Expressive dysphasiaLLTMedDRA10015714 Receptive dysphasiaLLTMedDRA10038009 C35546 Dysphasia E12646 Dyspnea 10013963 NCIA disorder characterized by an uncomfortable sensation of difficulty breathing. Acute dyspneaLLTMedDRA10066606 Acute dyspnoeaLLTMedDRA10066607 Air hungerLLTMedDRA10001529 Breath shortnessLLTMedDRA10006332 Breathing difficultLLTMedDRA10006338 BreathlessnessLLTMedDRA10006345 Difficulty breathingLLTMedDRA10012791 Dyspnea exacerbatedLLTMedDRA10013965 DyspneaLLTMedDRA10013963 DyspneaPTCTCAE Dyspnoea NOSLLTMedDRA10013972 Dyspnoea exacerbatedLLTMedDRA10013970 DyspnoeaLLTMedDRA10013968 GaspingLLTMedDRA10017745 Hunger airLLTMedDRA10020468 Increased shortness of breathLLTMedDRA10021680 Increased work of breathingLLTMedDRA10021696 Labored breathingLLTMedDRA10023552 Labored respirationLLTMedDRA10055564 Laboured breathingLLTMedDRA10023556 Laboured respirationLLTMedDRA10023557 Marked inactivity of chest wall on inspiratory effortLLTMedDRA10026837 Respiration laboredLLTMedDRA10038653 Respiration labouredLLTMedDRA10038654 Short of breathLLTMedDRA10040596 Shortness of breathLLTMedDRA10040604 C2998 Dyspnea E13368 Ear and labyrinth disorders 10013993 Ear and labyrinth disordersPTCTCAE E13865 Ear and labyrinth disorders Ear and labyrinth disorders - Other, specify Ear and labyrinth disorders - Other, specifyPTCTCAE E10256 Ear and labyrinth disorders - Other, specify Ear pain 10014020 NCIA disorder characterized by a sensation of marked discomfort in the ear. Ear acheLLTMedDRA10013992 Ear painLLTMedDRA10014020 Ear painPTCTCAE EaracheLLTMedDRA10014037 Otalgia, unspecifiedLLTMedDRA10031305 OtalgiaLLTMedDRA10031304 Otogenic painLLTMedDRA10033098 Pain earLLTMedDRA10033393 Pain in earLLTMedDRA10033423 Referred otogenic painLLTMedDRA10038237 C37944 E10262 Ear pain Edema cerebral 10014217 NCIA disorder characterized by swelling due to an excessive accumulation of fluid in the brain. Brain edemaLLTMedDRA10006121 Brain oedemaLLTMedDRA10048962 Brain swellingLLTMedDRA10058952 Cerebellar edemaLLTMedDRA10057359 Cerebellar oedemaLLTMedDRA10057360 Cerebral edemaLLTMedDRA10008107 Cerebral oedemaLLTMedDRA10008127 Edema brainLLTMedDRA10014216 Edema cerebralLLTMedDRA10014217 Edema cerebralPTCTCAE Oedema brainLLTMedDRA10055915 Oedema cerebralLLTMedDRA10030098 C4909 E12650 Edema cerebral Edema face 10014222 NCIA disorder characterized by swelling due to excessive fluid accumulation in facial tissues. Edema facePTCTCAE C78289 E11082 Edema face Edema limbs 10050068 NCIA disorder characterized by swelling due to excessive fluid accumulation in the upper or lower extremities. AcroedemaLLTMedDRA10058684 Ankle edemaLLTMedDRA10002542 Ankle oedemaLLTMedDRA10002546 Chronic edema of legsLLTMedDRA10066560 Chronic oedema of legsLLTMedDRA10066588 Edema armsLLTMedDRA10014214 Edema extremitiesLLTMedDRA10014220 Edema extremity upperLLTMedDRA10050063 Edema fingersLLTMedDRA10050064 Edema handsLLTMedDRA10050065 Edema kneesLLTMedDRA10050067 Edema legsLLTMedDRA10014230 Edema limbsLLTMedDRA10050068 Edema limbsPTCTCAE Edema lower limbLLTMedDRA10014232 Edema of extremitiesLLTMedDRA10014236 Edema of legsLLTMedDRA10014239 Edema of lower extremitiesLLTMedDRA10054498 Edema palmarLLTMedDRA10054500 Edema peripheral aggravatedLLTMedDRA10066708 Edema peripheralLLTMedDRA10014251 Edema thighLLTMedDRA10050070 Edema upper extremitiesLLTMedDRA10054505 Edema upper limbLLTMedDRA10014259 Edematous feetLLTMedDRA10014263 Fingers swollen feeling ofLLTMedDRA10016696 Foot edemaLLTMedDRA10016968 Foot oedemaLLTMedDRA10016971 Hand swellingLLTMedDRA10019121 Large arm swellingLLTMedDRA10023698 Leg edemaLLTMedDRA10024127 Leg oedemaLLTMedDRA10024129 Malleolus edemaLLTMedDRA10054469 Malleolus oedemaLLTMedDRA10052380 Oedema armsLLTMedDRA10030096 Oedema extremitiesLLTMedDRA10055917 Oedema extremity upperLLTMedDRA10055918 Oedema fingersLLTMedDRA10055920 Oedema handsLLTMedDRA10058204 Oedema kneesLLTMedDRA10055924 Oedema legsLLTMedDRA10030105 Oedema limbsLLTMedDRA10060442 Oedema lower limbLLTMedDRA10030109 Oedema of extremitiesLLTMedDRA10030115 Oedema of legsLLTMedDRA10030117 Oedema of lower extremitiesLLTMedDRA10030118 Oedema palmarLLTMedDRA10030121 Oedema peripheral aggravatedLLTMedDRA10066707 Oedema peripheralLLTMedDRA10030124 Oedema thighLLTMedDRA10055938 Oedema upper extremitiesLLTMedDRA10049905 Oedema upper limbLLTMedDRA10030132 Oedematous feetLLTMedDRA10030134 Palmoplantar edemaLLTMedDRA10054525 Palmoplantar oedemaLLTMedDRA10051300 Pedal edemaLLTMedDRA10034206 Pedal oedemaLLTMedDRA10055950 Peripheral edemaLLTMedDRA10034570 Peripheral oedemaLLTMedDRA10034611 Peripheral swellingLLTMedDRA10048959 Pretibial edemaLLTMedDRA10059808 Pretibial oedemaLLTMedDRA10059825 Swelling armLLTMedDRA10042680 Swelling of feetLLTMedDRA10042693 Swelling of fingersLLTMedDRA10042694 Swelling of handsLLTMedDRA10042695 Swelling of leg's soft tissueLLTMedDRA10042699 Swelling of legsLLTMedDRA10042700 Swelling of limbLLTMedDRA10042701 Swelling of limbsLLTMedDRA10042702 Swollen armLLTMedDRA10042716 Swollen thumbLLTMedDRA10042726 TrophedemaLLTMedDRA10044693 TrophoedemaLLTMedDRA10051462 Upper limb edemaLLTMedDRA10054683 Upper limb oedemaLLTMedDRA10048384 C78262 E11086 Edema limbs Edema trunk 10058720 NCIA disorder characterized by swelling due to excessive fluid accumulation in the trunk area. Edema abdomenLLTMedDRA10054486 Edema auricularLLTMedDRA10054488 Edema trunkLLTMedDRA10058720 Edema trunkPTCTCAE Localised oedemaLLTMedDRA10048961 Localized edemaLLTMedDRA10062466 Lumbar cushionLLTMedDRA10024990 Neck edema ofLLTMedDRA10055407 Neck edemaLLTMedDRA10054482 Neck oedema ofLLTMedDRA10028835 Neck oedemaLLTMedDRA10028834 Oedema abdomenLLTMedDRA10048651 Oedema auricularLLTMedDRA10030097 Oedema trunkLLTMedDRA10058691 Sacral edemaLLTMedDRA10039349 Sacral oedemaLLTMedDRA10039350 C78263 E11090 Edema trunk Ejaculation disorder 10014326 NCIA disorder characterized by problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation. Abnormal ejaculationLLTMedDRA10000128 Ejaculation abnormalLLTMedDRA10014323 Ejaculation disorder NOSLLTMedDRA10014327 Ejaculation disorderLLTMedDRA10014326 Ejaculation disorderPTCTCAE C78264 E13085 Ejaculation disorder Ejection fraction decreased 10050528 NCIThe percentage computed when the amount of blood ejected during a ventricular contraction of the heart is compared to the amount that was present prior to the contraction. Ejection fraction decreasedPTCTCAE C83492 E12142 Ejection fraction decreased Electrocardiogram QT corrected interval prolonged 10014383 NCIA finding of a cardiac dysrhythmia characterized by an abnormally long corrected QT interval. Electrocardiogram QT borderline prolongedLLTMedDRA10067573 Electrocardiogram QT corrected interval prolongedLLTMedDRA10014383 Electrocardiogram QT corrected interval prolongedPTCTCAE Electrocardiogram QT prolongedLLTMedDRA10014387 Electrocardiogram QTc interval prolongedLLTMedDRA10053698 Long QTLLTMedDRA10024802 Prolonged ventricular repolarisationLLTMedDRA10036887 Prolonged ventricular repolarizationLLTMedDRA10054581 QT increasedLLTMedDRA10037700 QT interval prolongedLLTMedDRA10037703 QT prolongedLLTMedDRA10037705 C71034 E12146 Electrocardiogram QT corrected interval prolonged Encephalitis infection 10014594 NCIA disorder characterized by an infectious process involving the brain tissue. Encephalitic infectionLLTMedDRA10058805 Encephalitis infection NOSLLTMedDRA10014595 Encephalitis infectionLLTMedDRA10014594 Encephalitis infectionPTCTCAE Encephalomyelitis infectionLLTMedDRA10014621 Post infectious encephalitisLLTMedDRA10057235 C79550 E11365 Encephalitis infection Encephalomyelitis infection 10014621 NCIA disorder characterized by an infectious process involving the brain and spinal cord tissues. Encephalitic infectionLLTMedDRA10058805 Encephalitis infection NOSLLTMedDRA10014595 Encephalitis infectionLLTMedDRA10014594 Encephalomyelitis infectionLLTMedDRA10014621 Encephalomyelitis infectionPTCTCAE Post infectious encephalitisLLTMedDRA10057235 C79551 E11369 Encephalomyelitis infection Encephalopathy 10014625 NCIA disorder characterized by a pathologic process involving the brain. Encephalopathy NOSLLTMedDRA10014636 Encephalopathy acuteLLTMedDRA10014626 Encephalopathy chronicLLTMedDRA10014629 Encephalopathy, unspecifiedLLTMedDRA10014641 EncephalopathyLLTMedDRA10014625 EncephalopathyPTCTCAE Influenza encephalopathyLLTMedDRA10058104 C26920 E12652 Encephalopathy Endocarditis infective 10014678 NCIA disorder characterized by an infectious process involving the endocardial layer of the heart. Endocarditis NOSLLTMedDRA10014681 Endocarditis infectiveLLTMedDRA10014678 Endocarditis infectivePTCTCAE Endocarditis, valve unspecified, unspecified causeLLTMedDRA10014689 Endocarditis, valve unspecifiedLLTMedDRA10014688 EndocarditisLLTMedDRA10014665 Native valve endocarditisLLTMedDRA10058161 Prosthetic valve endocarditisLLTMedDRA10036984 C78265 E11373 Endocarditis infective Endocrine disorders 10014698 Endocrine disordersPTCTCAE E13856 Endocrine disorders Endocrine disorders - Other, specify Endocrine disorders - Other, specifyPTCTCAE E10311 Endocrine disorders - Other, specify Endophthalmitis 10014801 NCIA disorder characterized by an infectious process involving the internal structures of the eye. Acute endophthalmitisLLTMedDRA10000730 Chronic endophthalmitisLLTMedDRA10008864 EndophthalmitisLLTMedDRA10014801 EndophthalmitisPTCTCAE Parasitic endophthalmitis NOSLLTMedDRA10033912 Purulent endophthalmitis, unspecifiedLLTMedDRA10037571 Purulent endophthalmitisLLTMedDRA10037570 C34586 E11377 Endophthalmitis Enterocolitis 10014893 NCIA disorder characterized by inflammation of the small and large intestines. Chronic enterocolitisLLTMedDRA10068198 EnterocolitisLLTMedDRA10014893 EnterocolitisPTCTCAE IleocolitisLLTMedDRA10062647 C79573 E10627 Enterocolitis Enterocolitis infectious 10058838 NCIA disorder characterized by an infectious process involving the small and large intestines. Enterocolitis infectiousPTCTCAE C80513 E11381 Enterocolitis infectious Enterovesical fistula 10062570 NCIA disorder characterized by an abnormal communication between the urinary bladder and the intestine. Colovesical fistulaLLTMedDRA10010066 Enterovesical fistulaLLTMedDRA10062570 Enterovesical fistulaPTCTCAE Intestinovesical fistulaLLTMedDRA10022722 Rectovesical fistulaLLTMedDRA10062648 C78266 E10633 Enterovesical fistula Epistaxis 10015090 NCIA disorder characterized by bleeding from the nose. Bleeding noseLLTMedDRA10005124 Chronic epistaxisLLTMedDRA10066563 EpistaxisLLTMedDRA10015090 EpistaxisPTCTCAE Haemorrhage nasalLLTMedDRA10018986 Hemorrhage nasalLLTMedDRA10019561 Nasal bleedingLLTMedDRA10028723 Nasal mucus blood tingedLLTMedDRA10028746 Nose bleedLLTMedDRA10029792 Nose bleedsLLTMedDRA10029793 NosebleedLLTMedDRA10029802 C26766 E13374 Epistaxis Erectile dysfunction 10061461 NCIA disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity. Decreased frequency of erectionsLLTMedDRA10067036 Erectile disturbanceLLTMedDRA10015116 Erectile dysfunction NOSLLTMedDRA10052003 Erectile dysfunctionLLTMedDRA10061461 Erectile dysfunctionPTCTCAE Erection decreasedLLTMedDRA10015117 Erection failureLLTMedDRA10015118 Erection inadequateLLTMedDRA10015119 Impotence aggravatedLLTMedDRA10048340 ImpotenceLLTMedDRA10021550 ImpotentLLTMedDRA10021552 Impotentia erigendiLLTMedDRA10021553 Inability to maintain erectionLLTMedDRA10021573 Male erectile disorderLLTMedDRA10025503 Potency disturbanceLLTMedDRA10054200 C3133 E13088 Erectile dysfunction Erythema multiforme 10015218 NCIA disorder characterized by target lesions (a pink-red ring around a pale center). Erythaema polymorpheLLTMedDRA10057866 Erythema exsudativum multiformeLLTMedDRA10015209 Erythema exudativum multiformeLLTMedDRA10015211 Erythema exudativumLLTMedDRA10015210 Erythema multiform-like eruptionLLTMedDRA10015217 Erythema multiforme exudativumLLTMedDRA10015219 Erythema multiforme minorLLTMedDRA10015221 Erythema multiforme type skin reactionLLTMedDRA10015223 Erythema multiforme type vasculitisLLTMedDRA10015224 Erythema multiformeLLTMedDRA10015218 Erythema multiformePTCTCAE Erythema polymorpheLLTMedDRA10057783 C3024 E13627 Erythema multiforme Erythroderma 10015277 NCIA disorder characterized by generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area. Dermatitis exfoliative NOSLLTMedDRA10012457 Dermatitis exfoliative aggravatedLLTMedDRA10048306 Dermatitis exfoliativeLLTMedDRA10012455 ErythrodermaLLTMedDRA10015277 ErythrodermaPTCTCAE Exfoliative dermatitis NOSLLTMedDRA10015666 Exfoliative dermatitisLLTMedDRA10015665 C39646 E13633 Erythroderma Esophageal anastomotic leak 10065961 NCIA finding of leakage due to breakdown of an esophageal anastomosis (surgical connection of two separate anatomic structures). Esophageal anastomotic leakLLTMedDRA10065961 Esophageal anastomotic leakPTCTCAE Gastric anastomotic leakLLTMedDRA10065893 Gastrointestinal anastomotic leakLLTMedDRA10065879 Intestinal anastomotic leakLLTMedDRA10054119 Large intestinal anastomotic leakLLTMedDRA10065891 Oesophageal anastomotic leakLLTMedDRA10065890 Rectal anastomotic leakLLTMedDRA10065894 Small intestinal anastomotic leakLLTMedDRA10065892 C78270 E11681 Esophageal anastomotic leak Esophageal fistula 10065851 NCIA disorder characterized by an abnormal communication between the esophagus and another organ or anatomic site. Esophageal fistulaLLTMedDRA10065851 Esophageal fistulaPTCTCAE Oesophageal fistulaLLTMedDRA10065835 C79574 E10639 Esophageal fistula Esophageal hemorrhage 10015384 NCIA disorder characterized by bleeding from the esophagus. Esophageal hemorrhageLLTMedDRA10015384 Esophageal hemorrhagePTCTCAE Haemorrhage oesophagealLLTMedDRA10060474 Hemorrhage esophagealLLTMedDRA10019535 Oesophageal haemorrhageLLTMedDRA10030172 C78271 E10645 Esophageal hemorrhage Esophageal infection 10058804 NCIA disorder characterized by an infectious process involving the esophagus. Esophageal infectionLLTMedDRA10058804 Esophageal infectionPTCTCAE Esophagitis infectionLLTMedDRA10058551 Oesophageal infectionLLTMedDRA10058803 Oesophagitis infectionLLTMedDRA10058548 C78277 E11386 Esophageal infection Esophageal necrosis 10065727 NCIA disorder characterized by a necrotic process occurring in the esophageal wall. Anal necrosisLLTMedDRA10065722 Duodenal necrosisLLTMedDRA10065725 Esophageal necrosisLLTMedDRA10065727 Esophageal necrosisPTCTCAE Gastric necrosisLLTMedDRA10051886 Gastrointestinal necrosisLLTMedDRA10017982 Ileal necrosisLLTMedDRA10065729 Intestinal necrosisLLTMedDRA10022686 Jejunal necrosisLLTMedDRA10065731 Necrosis bowelLLTMedDRA10028856 Necrosis intestinalLLTMedDRA10028861 Oesophageal necrosisLLTMedDRA10065737 Rectal necrosisLLTMedDRA10065709 Small intestinal necrosisLLTMedDRA10065711 C78278 E10651 Esophageal necrosis Esophageal obstruction 10015387 NCIA disorder characterized by blockage of the normal flow of the contents in the esophagus. Esophageal obstructionLLTMedDRA10015387 Esophageal obstructionPTCTCAE Obstruction esophagusLLTMedDRA10029956 Obstruction oesophagusLLTMedDRA10056101 Oesophageal obstructionLLTMedDRA10030178 C78279 E10655 Esophageal obstruction Esophageal pain 10015388 NCIA disorder characterized by a sensation of marked discomfort in the esophageal region. Burning esophagusLLTMedDRA10052160 Burning oesophagusLLTMedDRA10056093 EsophagalgiaLLTMedDRA10015299 Esophageal painLLTMedDRA10015388 Esophageal painPTCTCAE Oesophageal painLLTMedDRA10030180 Pain esophagealLLTMedDRA10033395 Pain oesophagealLLTMedDRA10056085 C78280 E10661 Esophageal pain Esophageal perforation 10055472 NCIA disorder characterized by a rupture in the wall of the esophagus. Esophageal perforationLLTMedDRA10055472 Esophageal perforationPTCTCAE Oesophageal perforationLLTMedDRA10030181 Perforation esophagusLLTMedDRA10034410 Perforation oesophagusLLTMedDRA10056103 Perforation of esophagusLLTMedDRA10034419 Perforation of oesophagusLLTMedDRA10034422 C50693 E10665 Esophageal perforation Esophageal stenosis 10015448 NCIA disorder characterized by a narrowing of the lumen of the esophagus. Esophageal scarringLLTMedDRA10065412 Esophageal stenosis acquiredLLTMedDRA10055479 Esophageal stenosisLLTMedDRA10015448 Esophageal stenosisPTCTCAE Esophageal strictureLLTMedDRA10015449 Oesophageal scarringLLTMedDRA10065406 Oesophageal stenosis acquiredLLTMedDRA10030195 Oesophageal stenosisLLTMedDRA10030194 Oesophageal strictureLLTMedDRA10030199 Stenosis esophagealLLTMedDRA10041978 Stenosis oesophagealLLTMedDRA10056088 Stricture esophagusLLTMedDRA10042231 Stricture oesophagusLLTMedDRA10056105 Stricture of esophagusLLTMedDRA10042235 Stricture of oesophagusLLTMedDRA10056106 C34595 E10670 Esophageal stenosis Esophageal ulcer 10015451 NCIA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the esophageal wall. Esophageal ulcerLLTMedDRA10015451 Esophageal ulcerPTCTCAE Esophageal ulcerationLLTMedDRA10055486 Esophagus ulcerationLLTMedDRA10015472 Oesophageal ulcerLLTMedDRA10030201 Oesophageal ulcerationLLTMedDRA10030203 Oesophagus ulcerationLLTMedDRA10056098 Ulcer esophagealLLTMedDRA10045302 Ulcer oesophagealLLTMedDRA10056090 Ulcer of esophagusLLTMedDRA10045323 Ulcer of oesophagusLLTMedDRA10045327 C26950 E10676 Esophageal ulcer Esophageal varices hemorrhage 10015453 NCIA disorder characterized by bleeding from esophageal varices. Bleeding esophageal varicesLLTMedDRA10005112 Bleeding oesophageal varicesLLTMedDRA10055968 Esophageal varices hemorrhageLLTMedDRA10015453 Esophageal varices hemorrhagePTCTCAE Esophageal varices rupturedLLTMedDRA10058127 Esophageal varices with bleedingLLTMedDRA10015458 Gastroesophageal varices hemorrhageLLTMedDRA10068934 Gastrooesophageal varices haemorrhageLLTMedDRA10068927 Oesophageal varices haemorrhageLLTMedDRA10030210 Oesophageal varices rupturedLLTMedDRA10058122 Oesophageal varices with bleedingLLTMedDRA10030213 C78282 E10682 Esophageal varices hemorrhage Esophagitis 10015461 NCIA disorder characterized by inflammation of the esophageal wall. Esophageal mucositisLLTMedDRA10065726 Esophagitis aggravatedLLTMedDRA10015462 Esophagitis, unspecifiedLLTMedDRA10015464 EsophagitisLLTMedDRA10015461 EsophagitisPTCTCAE Oesophageal mucositisLLTMedDRA10065960 Oesophagitis NOSLLTMedDRA10030220 Oesophagitis aggravatedLLTMedDRA10030217 OesophagitisLLTMedDRA10030216 Other esophagitisLLTMedDRA10032042 Sore esophagusLLTMedDRA10055499 Sore oesophagusLLTMedDRA10041365 Worsening of oesophagitisLLTMedDRA10048028 C9224 E10687 Esophagitis Euphoria 10015533 NCIA disorder characterized by an exaggerated feeling of well-being which is disproportionate to events and stimuli. EuphoriaLLTMedDRA10015533 EuphoriaPTCTCAE Euphoric moodLLTMedDRA10015535 EuphoricLLTMedDRA10015534 Exaggerated well-beingLLTMedDRA10015584 Feeling highLLTMedDRA10016333 Felt highLLTMedDRA10016382 High feelingLLTMedDRA10020063 C34598 E12915 Euphoria Exostosis 10015688 NCIA disorder characterized by non-neoplastic overgrowth of bone. Bone hypertrophyLLTMedDRA10005973 Bone spurLLTMedDRA10006012 Calcaneal spurLLTMedDRA10006933 Exostosis of jawLLTMedDRA10015690 Exostosis of orbitLLTMedDRA10015691 Exostosis of unspecified siteLLTMedDRA10015692 ExostosisLLTMedDRA10015688 ExostosisPTCTCAE Foot exostosisLLTMedDRA10016969 Haglund deformityLLTMedDRA10065541 Heel exostosisLLTMedDRA10049108 Hyperostosis of skullLLTMedDRA10020699 HyperostosisLLTMedDRA10020698 OsteophytosisLLTMedDRA10050016 Vertebral osteophyteLLTMedDRA10055042 C3029 E12404 Exostosis External ear inflammation 10065837 NCIA disorder characterized by inflammation, swelling and redness to the outer ear and ear canal. External ear inflammationLLTMedDRA10065837 External ear inflammationPTCTCAE C79601 E10266 External ear inflammation External ear pain 10065785 NCIA disorder characterized by a sensation of marked discomfort in the external ear region. External ear painLLTMedDRA10065785 External ear painPTCTCAE C78285 E10272 External ear pain Extraocular muscle paresis 10015829 NCIA disorder characterized by incomplete paralysis of an extraocular muscle. Extraocular muscle paresisLLTMedDRA10015829 Extraocular muscle paresisPTCTCAE Eye muscle weaknessLLTMedDRA10059456 C78286 E10367 Extraocular muscle paresis Extrapyramidal disorder 10015832 NCIA disorder characterized by abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness. Benign shuddering attacksLLTMedDRA10004456 Drug-induced extrapyramidal side effectsLLTMedDRA10013760 Extrapyramidal disorder aggravateLLTMedDRA10048325 Extrapyramidal disorder aggravatedLLTMedDRA10058837 Extrapyramidal disorderLLTMedDRA10015832 Extrapyramidal disorderPTCTCAE Extrapyramidal symptomsLLTMedDRA10015835 Extrapyramidal syndromeLLTMedDRA10015836 Syndrome extrapyramidalLLTMedDRA10042804 C79593 E12658 Extrapyramidal disorder Eye disorders 10015919 Eye disordersPTCTCAE E13866 Eye disorders Eye disorders - Other, specify Eye disorders - Other, specifyPTCTCAE E10371 Eye disorders - Other, specify Eye infection 10015929 NCIA disorder characterized by an infectious process involving the eye. Eye infection NOSLLTMedDRA10015936 Eye infectionLLTMedDRA10015929 Eye infectionPTCTCAE Parasitic infestation of orbitLLTMedDRA10033916 C45372 E11391 Eye infection Eye pain 10015958 NCIA disorder characterized by a sensation of marked discomfort in the eye. Aching eye socketLLTMedDRA10000446 Dull eye painLLTMedDRA10061083 Eye acheLLTMedDRA10015906 Eye painLLTMedDRA10015958 Eye painPTCTCAE Eye painful redLLTMedDRA10015959 Eye prick pain ofLLTMedDRA10015961 Eye tendernessLLTMedDRA10015968 Eyeball sorenessLLTMedDRA10015974 Eyes stingingLLTMedDRA10016012 Ocular painLLTMedDRA10067261 Ocular stingingLLTMedDRA10030065 OculodyniaLLTMedDRA10065571 OphthalmalgiaLLTMedDRA10065576 Orbital painLLTMedDRA10031053 Pain behind eyesLLTMedDRA10033381 Pain eyeLLTMedDRA10033397 Pain in eyesLLTMedDRA10033426 Painful red eyesLLTMedDRA10033516 Periorbital painLLTMedDRA10034546 Retro-orbital painLLTMedDRA10050741 Sore eyeLLTMedDRA10041356 Sore eyesLLTMedDRA10041357 Sore inner canthusLLTMedDRA10041361 Soreness in eyesLLTMedDRA10041372 Stinging sensation in eyesLLTMedDRA10042068 Tenderness eyeLLTMedDRA10043228 C78287 E10376 Eye pain Eyelid function disorder 10061145 NCIA disorder characterized by impaired eyelid function. Eyelid function disorder NOSLLTMedDRA10015986 Eyelid function disorderLLTMedDRA10061145 Eyelid function disorderPTCTCAE C78288 E10380 Eyelid function disorder Facial muscle weakness 10051272 NCIA disorder characterized by a reduction in the strength of the facial muscles. Brow ptosisLLTMedDRA10059001 Facial muscle weaknessLLTMedDRA10051272 Facial muscle weaknessPTCTCAE Facial paresisLLTMedDRA10051267 Facial weaknessLLTMedDRA10051271 C78290 E12664 Facial muscle weakness Facial nerve disorder 10061457 NCIA disorder characterized by involvement of the facial nerve (seventh cranial nerve). Bilateral VIIth nerve lesionLLTMedDRA10004584 Facial nerve disorder NOSLLTMedDRA10016051 Facial nerve disorder, unspecifiedLLTMedDRA10016052 Facial nerve disorderLLTMedDRA10061457 Facial nerve disorderPTCTCAE VIIth nerve lesionLLTMedDRA10047412 C27594 E12668 Facial nerve disorder Facial pain 10016059 NCIA disorder characterized by a sensation of marked discomfort in the face. Atypical face painLLTMedDRA10003749 Facial painLLTMedDRA10016059 Facial painPTCTCAE Pain in faceLLTMedDRA10033427 C79594 E11094 Facial pain Fall 10016173 NCIA finding of sudden movement downward, usually resulting in injury. FallLLTMedDRA10016173 FallPTCTCAE Falling downLLTMedDRA10016178 FallingLLTMedDRA10016177 Loss of postureLLTMedDRA10024873 C50558 E11687 Fall Fallopian tube anastomotic leak 10065788 NCIA finding of leakage due to breakdown of a fallopian tube anastomosis (surgical connection of two separate anatomic structures). Fallopian tube anastomotic leakLLTMedDRA10065788 Fallopian tube anastomotic leakPTCTCAE Reproductive tract anastomotic leakLLTMedDRA10065833 Spermatic cord anastomotic leakLLTMedDRA10065897 Uterine anastomotic leakLLTMedDRA10065886 Vaginal anastomotic leakLLTMedDRA10065887 Vas deferens anastomotic leakLLTMedDRA10065888 C78292 E11691 Fallopian tube anastomotic leak Fallopian tube obstruction 10065789 NCIA disorder characterized by blockage of the normal flow of the contents in the fallopian tube. Fallopian tube obstructionLLTMedDRA10065789 Fallopian tube obstructionPTCTCAE C78293 E13092 Fallopian tube obstruction Fallopian tube perforation 10065790 NCIA finding of rupture of the fallopian tube wall. Fallopian tube perforationLLTMedDRA10065790 Fallopian tube perforationPTCTCAE C78294 E11697 Fallopian tube perforation Fallopian tube stenosis 10065791 NCIA disorder characterized by a narrowing of the fallopian tube lumen. Fallopian tube stenosisLLTMedDRA10065791 Fallopian tube stenosisPTCTCAE C78295 E13096 Fallopian tube stenosis Fat atrophy 10016241 NCIA disorder characterized by shrinking of adipose tissue. Fat atrophy NOSLLTMedDRA10016242 Fat atrophyLLTMedDRA10016241 Fat atrophyPTCTCAE Limb lipoatrophyLLTMedDRA10059182 LipoatrophyLLTMedDRA10024604 C78297 E13638 Fat atrophy Fatigue 10016256 NCIA disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities. Chronic fatigueLLTMedDRA10066564 Exhaustion due to excessive exertionLLTMedDRA10015668 Exhaustion due to exposureLLTMedDRA10015669 ExhaustionLLTMedDRA10015667 Fatigability generalizedLLTMedDRA10016253 Fatigability lumbarLLTMedDRA10016254 Fatigability of kneesLLTMedDRA10016255 FatigabilityLLTMedDRA10016252 Fatigue aggravatedLLTMedDRA10048415 Fatigue extremeLLTMedDRA10016257 FatigueLLTMedDRA10016256 FatiguePTCTCAE Fatigueability generalisedLLTMedDRA10065603 FatigueabilityLLTMedDRA10016259 LassitudeLLTMedDRA10023929 ProstrationLLTMedDRA10036985 Tired all the timeLLTMedDRA10043885 Tired outLLTMedDRA10043889 TirednessLLTMedDRA10043890 Washed-outLLTMedDRA10047830 WearinessLLTMedDRA10047871 Worn outLLTMedDRA10048024 C3036 E11098 Fatigue Febrile neutropenia 10016288 NCIA disorder characterized by an ANC <1000/mm3 and a single temperature of >38.3 degrees C (101 degrees F) or a sustained temperature of >=38 degrees C (100.4 degrees F) for more than one hour. Febrile neutropeniaLLTMedDRA10016288 Febrile neutropeniaPTCTCAE Neutropenic feverLLTMedDRA10051312 C35665 E10033 Febrile neutropenia Fecal incontinence 10016296 NCIA disorder characterized by inability to control the escape of stool from the rectum. Bowel incontinenceLLTMedDRA10050492 Faecal incontinence aggravatedLLTMedDRA10048477 Faecal incontinenceLLTMedDRA10016092 Fecal incontinence aggravatedLLTMedDRA10055507 Fecal incontinenceLLTMedDRA10016296 Fecal incontinencePTCTCAE Feces incontinence ofLLTMedDRA10016310 Incontinence faecalLLTMedDRA10056118 Incontinence fecalLLTMedDRA10021640 Incontinence of fecesLLTMedDRA10021641 Incontinent of faecesLLTMedDRA10021646 Involuntary bowel movementLLTMedDRA10065601 C78498 E10693 Fecal incontinence Female genital tract fistula 10061149 NCIA disorder characterized by an abnormal communication between a female reproductive system organ and another organ or anatomic site. Colovaginal fistulaLLTMedDRA10010065 Digestive-genital tract fistula, femaleLLTMedDRA10012988 Digestive-genital tract fistulae, femaleLLTMedDRA10012989 Enterovaginal fistulaLLTMedDRA10052320 Female genital tract fistula NOSLLTMedDRA10016393 Female genital tract fistulaLLTMedDRA10061149 Female genital tract fistulaPTCTCAE Female genital-digestive tract fistula NOSLLTMedDRA10016395 Female genital-digestive tract fistulaLLTMedDRA10061151 Female genital-skin fistula NOSLLTMedDRA10016396 Female genital-skin fistulaLLTMedDRA10061152 Fistula involving female genital tractLLTMedDRA10016723 Fistulae involving female genital tractLLTMedDRA10016730 Genital tract-skin fistula, femaleLLTMedDRA10018178 Genital tract-skin fistulae, femaleLLTMedDRA10018179 Ileovaginal fistulaLLTMedDRA10051096 Rectovaginal fistulaLLTMedDRA10051097 Unspecified fistula involving female genital tractLLTMedDRA10045875 C78298 E13102 Female genital tract fistula Feminization acquired 10054382 NCIA disorder characterized by the development of secondary female sex characteristics in males due to extrinsic factors. Feminisation acquiredLLTMedDRA10049290 FeminisationLLTMedDRA10016423 Feminization acquiredLLTMedDRA10054382 Feminization acquiredPTCTCAE FeminizationLLTMedDRA10016424 C78299 E13108 Feminization acquired Fetal death 10016479 NCIA disorder characterized by death in utero; failure of the product of conception to show evidence of respiration, heartbeat, or definite movement of a voluntary muscle after expulsion from the uterus, without possibility of resuscitation. Dead fetusLLTMedDRA10060517 Dead foetusLLTMedDRA10011872 Death fetalLLTMedDRA10011908 Death foetalLLTMedDRA10011909 Death intrauterineLLTMedDRA10011911 Fetal death from asphyxia or anoxia during laborLLTMedDRA10016482 Fetal death in uteroLLTMedDRA10016484 Fetal deathLLTMedDRA10016479 Fetal deathPTCTCAE Fetus maceratedLLTMedDRA10016539 Foetal death from asphyxia or anoxia during labourLLTMedDRA10058160 Foetal death in uteroLLTMedDRA10055691 Foetal deathLLTMedDRA10055690 Foetus maceratedLLTMedDRA10016873 Intra-uterine deathLLTMedDRA10022747 Intrauterine death affecting management of motherLLTMedDRA10022814 Intrauterine death, affecting management of mother, antepartumLLTMedDRA10022815 Intrauterine death, affecting management of mother, deliveredLLTMedDRA10022816 Twin pregnancy with fetal loss and retention of one fetusLLTMedDRA10045189 Twin pregnancy with foetal loss and retention of one foetusLLTMedDRA10055710 C50620 E12855 Fetal death Fetal growth retardation 10054746 NCIA disorder characterized by inhibition of fetal growth resulting in the inability of the fetus to achieve its potential weight. Fetal growth retardation, unspecified {weight}LLTMedDRA10016498 Fetal growth retardation, unspecified, 1,000-1,249 gramsLLTMedDRA10016499 Fetal growth retardation, unspecified, 1,250-1,499 gramsLLTMedDRA10016500 Fetal growth retardation, unspecified, 1,500-1,749 gramsLLTMedDRA10016501 Fetal growth retardation, unspecified, 1,750-1,999 gramsLLTMedDRA10016502 Fetal growth retardation, unspecified, 2,000-2,499 gramsLLTMedDRA10016503 Fetal growth retardation, unspecified, 2,500+ gramsLLTMedDRA10016504 Fetal growth retardation, unspecified, 500-749 gramsLLTMedDRA10016505 Fetal growth retardation, unspecified, 750-999 gramsLLTMedDRA10016506 Fetal growth retardation, unspecified, less than 500 gramsLLTMedDRA10016507 Fetal growth retardation, unspecifiedLLTMedDRA10016497 Fetal growth retardationLLTMedDRA10054746 Fetal growth retardationPTCTCAE Fetal maturation impairedLLTMedDRA10016521 Foetal growth retardation, unspecified {weight}LLTMedDRA10055696 Foetal growth retardation, unspecified, 1,000-1,249 gramsLLTMedDRA10055697 Foetal growth retardation, unspecified, 1,250-1,499 gramsLLTMedDRA10055698 Foetal growth retardation, unspecified, 1,500-1,749 gramsLLTMedDRA10055699 Foetal growth retardation, unspecified, 1,750-1,999 gramsLLTMedDRA10055700 Foetal growth retardation, unspecified, 2,000-2,499 gramsLLTMedDRA10055701 Foetal growth retardation, unspecified, 2,500+ gramsLLTMedDRA10055702 Foetal growth retardation, unspecified, 500-749 gramsLLTMedDRA10055703 Foetal growth retardation, unspecified, 750-999 gramsLLTMedDRA10055704 Foetal growth retardation, unspecified, less than 500 gramsLLTMedDRA10055705 Foetal growth retardation, unspecifiedLLTMedDRA10055695 Foetal growth retardationLLTMedDRA10016857 Foetal maturation impairedLLTMedDRA10016865 Growth intrauterine retardLLTMedDRA10048488 Intrauterine growth retardLLTMedDRA10048489 Intrauterine growth retardationLLTMedDRA10022819 C80083 E12857 Fetal growth retardation Fever 10016558 NCIA disorder characterized by elevation of the body's temperature above the upper limit of normal. Chronic feverLLTMedDRA10066565 Cotton feverLLTMedDRA10063757 Drug feverLLTMedDRA10013697 FebriculaLLTMedDRA10065377 Febrile reactionLLTMedDRA10016289 Fever chillsLLTMedDRA10016559 Fever of unknown originLLTMedDRA10016563 FeverLLTMedDRA10016558 FeverPTCTCAE Fluctuating feverLLTMedDRA10065602 High temperatureLLTMedDRA10020083 Intermittent feverLLTMedDRA10058698 Intermittent pyrexiaLLTMedDRA10022571 PUOLLTMedDRA10037511 Periodic feverLLTMedDRA10034533 Pyrexia NOSLLTMedDRA10037663 Pyrexia abnormalLLTMedDRA10037661 Pyrexia drugLLTMedDRA10037662 Pyrexia of unknown origin (excl puerperal)LLTMedDRA10037665 Pyrexia of unknown originLLTMedDRA10037664 PyrexiaLLTMedDRA10037660 PyrexialLLTMedDRA10037668 Reaction febrileLLTMedDRA10037946 Slight feverLLTMedDRA10041021 Slight temperatureLLTMedDRA10053568 Spiking temperatureLLTMedDRA10041523 C3038 E11102 Fever Fibrinogen decreased 10016596 NCIA finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen. Blood fibrinogen decreasedLLTMedDRA10005520 Decreased plasma fibrinogenLLTMedDRA10011976 Fibrinogen decreasedLLTMedDRA10016596 Fibrinogen decreasedPTCTCAE Fibrinogen plasma decreasedLLTMedDRA10016598 FibrinogenopeniaLLTMedDRA10016600 C78300 E12151 Fibrinogen decreased Fibrosis deep connective tissue 10065799 NCIA disorder characterized by fibrotic degeneration of the deep connective tissues. Fibrosis deep connective tissueLLTMedDRA10065799 Fibrosis deep connective tissuePTCTCAE Soft tissue disorder NOSLLTMedDRA10041289 Soft tissue disorderLLTMedDRA10061366 Superficial soft tissue fibrosisLLTMedDRA10065798 C78301 E12408 Fibrosis deep connective tissue Flank pain 10016750 NCIA disorder characterized by marked discomfort sensation on the lateral side of the body in the region below the ribs and above the hip. Flank painLLTMedDRA10016750 Flank painPTCTCAE Pain flankLLTMedDRA10033399 Side stitchLLTMedDRA10063898 C34615 E12414 Flank pain Flashing lights 10016757 NCIA disorder characterized by a sudden or brief burst of light. Flash visionLLTMedDRA10016753 Flashing lightsLLTMedDRA10016757 Flashing lightsPTCTCAE Flashing visionLLTMedDRA10016758 PhotopsiaLLTMedDRA10034962 Visual flashesLLTMedDRA10047569 C50568 E10384 Flashing lights Flatulence 10016766 NCIA disorder characterized by a state of excessive gas in the alimentary canal. Abdominal windLLTMedDRA10000107 Air in intestinesLLTMedDRA10001530 Air in stomachLLTMedDRA10001531 Excessive flatulenceLLTMedDRA10015604 FlatulenceLLTMedDRA10016766 FlatulencePTCTCAE Flatus increasedLLTMedDRA10016771 FlatusLLTMedDRA10016769 Gas evolution in intestineLLTMedDRA10017736 Gas in stomachLLTMedDRA10017738 Gas painLLTMedDRA10017739 GasLLTMedDRA10017735 GaseousnessLLTMedDRA10017743 Malodorous flatulenceLLTMedDRA10063052 MeteorismLLTMedDRA10027493 Pain gasLLTMedDRA10033401 TympanitesLLTMedDRA10045213 WindLLTMedDRA10047989 C37954 E10697 Flatulence Floaters 10016778 NCIA disorder characterized by an individual seeing spots before their eyes. The spots are shadows of opaque cell fragments in the vitreous humor or lens. Eye floatersLLTMedDRA10015924 Floaters in eyeLLTMedDRA10016779 Floaters vitreousLLTMedDRA10016780 FloatersLLTMedDRA10016778 FloatersPTCTCAE Muscae volitanteLLTMedDRA10028284 MyodesopsiaLLTMedDRA10028623 Persistent hyaloidLLTMedDRA10034710 Vitreal cellsLLTMedDRA10066421 Vitreous floaterLLTMedDRA10047653 Vitreous floatersLLTMedDRA10047654 C37955 E10388 Floaters Flu like symptoms 10016791 NCIA disorder characterized by a group of symptoms similar to those observed in patients with the flu. It includes fever, chills, body aches, malaise, loss of appetite and dry cough. Flu like symptomsLLTMedDRA10016791 Flu like symptomsPTCTCAE Flu-like achingLLTMedDRA10016795 Flu-like illnessLLTMedDRA10016796 Flu-like symptomsLLTMedDRA10016797 Influenza like illnessLLTMedDRA10022004 Influenza-like symptomsLLTMedDRA10022009 C78302 E11108 Flu like symptoms Flushing 10016825 NCIA disorder characterized by episodic reddening of the face. Facial flushingLLTMedDRA10016046 Flushed chestLLTMedDRA10016822 Flushed faceLLTMedDRA10016823 Flushed skinLLTMedDRA10016824 FlushedLLTMedDRA10016821 Flushing aggravatedLLTMedDRA10048347 Flushing of faceLLTMedDRA10016826 FlushingLLTMedDRA10016825 FlushingPTCTCAE Generalised flushingLLTMedDRA10018083 Generalized flushingLLTMedDRA10062435 Gross flushingLLTMedDRA10018742 Skin flushedLLTMedDRA10040850 C26775 E13771 Flushing Forced expiratory volume decreased 10016987 NCIA finding based on test results that indicate a relative decrease in the fraction of the forced vital capacity that is exhaled in a specific number of seconds. FEV 1 decreasedLLTMedDRA10016550 FEV 1 lowLLTMedDRA10016553 FEV decreasedLLTMedDRA10016555 Forced expiratory volume decreasedLLTMedDRA10016987 Forced expiratory volume decreasedPTCTCAE C50524 E12156 Forced expiratory volume decreased Fracture 10017076 NCIA finding of traumatic injury to the bone in which the continuity of the bone is broken. Bone fracture (not spontaneous)LLTMedDRA10005964 Bone splinterLLTMedDRA10058048 Broken bonesLLTMedDRA10006381 Fracture NOSLLTMedDRA10017089 Fracture boneLLTMedDRA10017077 FractureLLTMedDRA10017076 FracturePTCTCAE C3046 E11703 Fracture GGT increased 10056910 NCIA finding based on laboratory test results that indicate higher than normal levels of the enzyme gamma-glutamyltransferase in the blood specimen. GGT (gamma-glutamyltransferase ) catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, amino acids or water. GGT increasedLLTMedDRA10056910 GGT increasedPTCTCAE GGTP increaseLLTMedDRA10018221 Gamma GT increasedLLTMedDRA10017670 Gamma GT raisedLLTMedDRA10017671 Gamma glutamyl transpeptidase increasedLLTMedDRA10017668 Gamma-GT increasedLLTMedDRA10017696 Gamma-glutamyltransferase highLLTMedDRA10017691 Gamma-glutamyltransferase increasedLLTMedDRA10017693 C26943 E12161 GGT increased Gait disturbance 10017577 NCIA disorder characterized by walking difficulties. Abnormal gaitLLTMedDRA10000136 Abnormality of gaitLLTMedDRA10000200 Antalgic gaitLLTMedDRA10063359 Difficulty in walking involving joint, site unspecifiedLLTMedDRA10012799 Difficulty in walking involving lower leg jointLLTMedDRA10012800 Difficulty in walkingLLTMedDRA10012794 Disorder gaitLLTMedDRA10013224 DysbasiaLLTMedDRA10013890 Gait abnormal NOSLLTMedDRA10017574 Gait abnormalLLTMedDRA10017573 Gait broadenedLLTMedDRA10017575 Gait disorderLLTMedDRA10017576 Gait disturbanceLLTMedDRA10017577 Gait disturbancePTCTCAE Gait instabilityLLTMedDRA10017582 Gait shufflingLLTMedDRA10017584 Gait staggeringLLTMedDRA10017586 Gait stumblingLLTMedDRA10017587 Gait trippingLLTMedDRA10017588 Gait unsteadyLLTMedDRA10017589 Instability gaitLLTMedDRA10022455 Leg draggingLLTMedDRA10058725 LimpingLLTMedDRA10058726 Staggering gaitLLTMedDRA10041903 StaggeringLLTMedDRA10041902 Steppage gaitLLTMedDRA10066777 StumblingLLTMedDRA10042262 TitubationLLTMedDRA10043895 Unsteady gaitLLTMedDRA10046261 Waddling gaitLLTMedDRA10066245 Walking difficultyLLTMedDRA10047810 Wide-based gaitLLTMedDRA10047982 C78303 E11112 Gait disturbance Gallbladder fistula 10017631 NCIA disorder characterized by an abnormal communication between the gallbladder and another organ or anatomic site. Fistula of gallbladderLLTMedDRA10016726 Gallbladder fistulaLLTMedDRA10017631 Gallbladder fistulaPTCTCAE C78305 E11189 Gallbladder fistula Gallbladder infection 10062632 NCIA disorder characterized by an infectious process involving the gallbladder. Cholecystitis infectiveLLTMedDRA10062631 Gallbladder gangreneLLTMedDRA10049554 Gallbladder infectionLLTMedDRA10062632 Gallbladder infectionPTCTCAE Gangrenous cholecystitisLLTMedDRA10063158 C78306 E11396 Gallbladder infection Gallbladder necrosis 10059446 NCIA disorder characterized by a necrotic process occurring in the gallbladder. Gallbladder necrosisLLTMedDRA10059446 Gallbladder necrosisPTCTCAE C78307 E11195 Gallbladder necrosis Gallbladder obstruction 10017636 NCIA disorder characterized by blockage of the normal flow of the contents of the gallbladder. Courvoisier's gallbladderLLTMedDRA10059153 Gallbladder obstructionLLTMedDRA10017636 Gallbladder obstructionPTCTCAE Obstruction of gallbladderLLTMedDRA10029965 C78308 E11198 Gallbladder obstruction Gallbladder pain 10017638 NCIA disorder characterized by a sensation of marked discomfort in the gallbladder region. Gallbladder painLLTMedDRA10017638 Gallbladder painPTCTCAE C78304 E11204 Gallbladder pain Gallbladder perforation 10017639 NCIA disorder characterized by a rupture in the gallbladder wall. Gallbladder perforationLLTMedDRA10017639 Gallbladder perforationPTCTCAE Perforation of gallbladderLLTMedDRA10034420 C78309 E11208 Gallbladder perforation Gastric anastomotic leak 10065893 NCIA finding of leakage due to breakdown of a gastric anastomosis (surgical connection of two separate anatomic structures). Esophageal anastomotic leakLLTMedDRA10065961 Gastric anastomotic leakLLTMedDRA10065893 Gastric anastomotic leakPTCTCAE Gastrointestinal anastomotic leakLLTMedDRA10065879 Intestinal anastomotic leakLLTMedDRA10054119 Large intestinal anastomotic leakLLTMedDRA10065891 Oesophageal anastomotic leakLLTMedDRA10065890 Rectal anastomotic leakLLTMedDRA10065894 Small intestinal anastomotic leakLLTMedDRA10065892 C78310 E11709 Gastric anastomotic leak Gastric fistula 10065713 NCIA disorder characterized by an abnormal communication between the stomach and another organ or anatomic site. Gastric fistulaLLTMedDRA10065713 Gastric fistulaPTCTCAE C79595 E10700 Gastric fistula Gastric hemorrhage 10017789 NCIA disorder characterized by bleeding from the gastric wall. Gastric bleedingLLTMedDRA10017757 Gastric haemorrhageLLTMedDRA10017788 Gastric hemorrhageLLTMedDRA10017789 Gastric hemorrhagePTCTCAE Gastric mucosal hypertrophy, with haemorrhageLLTMedDRA10055792 Gastric mucosal hypertrophy, with hemorrhageLLTMedDRA10017809 Gastric submucosal haemorrhageLLTMedDRA10017820 Gastric submucosal hemorrhageLLTMedDRA10055249 Haemorrhage gastricLLTMedDRA10018978 Haemorrhage stomachLLTMedDRA10055844 Hemorrhage gastricLLTMedDRA10019542 Hemorrhage stomachLLTMedDRA10019586 Stomach haemorrhageLLTMedDRA10055871 Stomach hemorrhageLLTMedDRA10042109 C54582 E10706 Gastric hemorrhage Gastric necrosis 10051886 NCIA disorder characterized by a necrotic process occurring in the gastric wall. Anal necrosisLLTMedDRA10065722 Duodenal necrosisLLTMedDRA10065725 Esophageal necrosisLLTMedDRA10065727 Gastric necrosisLLTMedDRA10051886 Gastric necrosisPTCTCAE Gastrointestinal necrosisLLTMedDRA10017982 Ileal necrosisLLTMedDRA10065729 Intestinal necrosisLLTMedDRA10022686 Jejunal necrosisLLTMedDRA10065731 Necrosis bowelLLTMedDRA10028856 Necrosis intestinalLLTMedDRA10028861 Oesophageal necrosisLLTMedDRA10065737 Rectal necrosisLLTMedDRA10065709 Small intestinal necrosisLLTMedDRA10065711 C78314 E10712 Gastric necrosis Gastric perforation 10017815 NCIA disorder characterized by a rupture in the stomach wall. Gastric perforationLLTMedDRA10017815 Gastric perforationPTCTCAE Perforation stomachLLTMedDRA10034430 Stomach perforationLLTMedDRA10042113 C78316 E10716 Gastric perforation Gastric stenosis 10061970 NCIA disorder characterized by a narrowing of the lumen of the stomach. Gastric stenosis NOSLLTMedDRA10017819 Gastric stenosisLLTMedDRA10061970 Gastric stenosisPTCTCAE Hourglass stricture or stenosis of stomachLLTMedDRA10020418 C78317 E10721 Gastric stenosis Gastric ulcer 10017822 NCIA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the stomach. Acute gastric ulcer without mention of haemorrhage or perforationLLTMedDRA10000765 Acute gastric ulcer without mention of hemorrhage or perforationLLTMedDRA10000766 Antral ulcerLLTMedDRA10057082 Chronic gastric ulcer without mention of haemorrhage or perforationLLTMedDRA10008878 Chronic gastric ulcer without mention of hemorrhage or perforationLLTMedDRA10008879 GULLTMedDRA10018765 Gastric ulcer reactivationLLTMedDRA10017837 Gastric ulcerLLTMedDRA10017822 Gastric ulcerPTCTCAE Gastroesophageal junction ulcerLLTMedDRA10053417 Greater curvature gastric ulcerLLTMedDRA10018718 Lesser curvature gastric ulcerLLTMedDRA10024254 Multiple gastric ulcersLLTMedDRA10028209 Prepyloric ulcerLLTMedDRA10050174 Pyloric ulcerLLTMedDRA10037625 Pylorus ulcerLLTMedDRA10037630 Reactivated GULLTMedDRA10037988 Stomach ulcer reactivatedLLTMedDRA10042118 Stomach ulcerLLTMedDRA10042116 Ulcer gastricLLTMedDRA10045304 Ulcer prepyloricLLTMedDRA10049772 Ulcer stomach reactivatedLLTMedDRA10045337 Ulcer stomachLLTMedDRA10045336 Ulcus ventriculiLLTMedDRA10045374 C3388 E10727 Gastric ulcer Gastritis 10017853 NCIA disorder characterized by inflammation of the stomach. Acute gastritis, without mention of haemorrhageLLTMedDRA10060460 Acute gastritis, without mention of hemorrhageLLTMedDRA10000771 Acute gastritisLLTMedDRA10000769 Chronic gastritisLLTMedDRA10008882 Gastric hyperaemiaLLTMedDRA10067634 Gastric hyperemiaLLTMedDRA10067629 Gastric inflammationLLTMedDRA10017790 Gastric mucositisLLTMedDRA10065715 Gastritis NOSLLTMedDRA10017869 Gastritis acuteLLTMedDRA10017855 Gastritis aggravatedLLTMedDRA10048360 Gastritis chronicLLTMedDRA10017864 GastritisLLTMedDRA10017853 GastritisPTCTCAE Granulomatous gastritisLLTMedDRA10057083 Inflammation stomachLLTMedDRA10021967 Phlegmonous gastritisLLTMedDRA10034909 Stomach inflammationLLTMedDRA10042110 Superficial gastritisLLTMedDRA10068200 C26780 E10733 Gastritis Gastroesophageal reflux disease 10066874 NCIA disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is chronic in nature and usually caused by incompetence of the lower esophageal sphincter, and may result in injury to the esophageal mucosal. Symptoms include heartburn and acid indigestion. Gastroesophageal reflux diseasePTCTCAE C26781 E10739 Gastroesophageal reflux disease Gastrointestinal anastomotic leak 10065879 NCIA finding of leakage due to breakdown of a gastrointestinal anastomosis (surgical connection of two separate anatomic structures). Esophageal anastomotic leakLLTMedDRA10065961 Gastric anastomotic leakLLTMedDRA10065893 Gastrointestinal anastomotic leakLLTMedDRA10065879 Gastrointestinal anastomotic leakPTCTCAE Intestinal anastomotic leakLLTMedDRA10054119 Large intestinal anastomotic leakLLTMedDRA10065891 Oesophageal anastomotic leakLLTMedDRA10065890 Rectal anastomotic leakLLTMedDRA10065894 Small intestinal anastomotic leakLLTMedDRA10065892 C78318 E11715 Gastrointestinal anastomotic leak Gastrointestinal disorders 10017947 Gastrointestinal disordersPTCTCAE E13859 Gastrointestinal disorders Gastrointestinal disorders - Other, specify Gastrointestinal disorders - Other, specifyPTCTCAE E10743 Gastrointestinal disorders - Other, specify Gastrointestinal fistula 10017877 NCIA disorder characterized by an abnormal communication between any part of the gastrointestinal system and another organ or anatomic site. Gastrointestinal fistulaLLTMedDRA10017877 Gastrointestinal fistulaPTCTCAE C78319 E10749 Gastrointestinal fistula Gastrointestinal pain 10017999 NCIA disorder characterized by a sensation of marked discomfort in the gastrointestinal region. Bowel crampsLLTMedDRA10049898 Bowel spasmLLTMedDRA10066080 GI painLLTMedDRA10018241 Gastrointestinal crampsLLTMedDRA10049136 Gastrointestinal pain NOSLLTMedDRA10018000 Gastrointestinal painLLTMedDRA10017999 Gastrointestinal painPTCTCAE Gut painLLTMedDRA10018796 Intestinal crampsLLTMedDRA10049900 Intestinal spasmLLTMedDRA10049476 Spasm intestinalLLTMedDRA10041388 C78320 E10755 Gastrointestinal pain Gastrointestinal stoma necrosis 10065712 NCIA finding of a necrotic process occurring in the gastrointestinal tract stoma. Colostomy malfunctionLLTMedDRA10010047 Colostomy prolapseLLTMedDRA10058044 Continent ileostomy complicationLLTMedDRA10058932 Gastrointestinal stoma complicationLLTMedDRA10065718 Gastrointestinal stoma necrosisLLTMedDRA10065712 Gastrointestinal stoma necrosisPTCTCAE Ileostomy malfunctionLLTMedDRA10021324 Ileostomy overactiveLLTMedDRA10021326 Ileostomy underactiveLLTMedDRA10059093 Intestinal stoma complicationLLTMedDRA10059060 Intestinal stoma leakLLTMedDRA10059095 Intestinal stoma obstructionLLTMedDRA10059094 Jejunostomy malfunctionLLTMedDRA10052091 Obstructed colostomyLLTMedDRA10059092 Obstructed ileostomyLLTMedDRA10059091 Other complication of colostomy or enterostomyLLTMedDRA10031765 Overactive ileostomyLLTMedDRA10033290 Prolapse of intestinal stomaLLTMedDRA10065745 Stenosis of gastrointestinal stomaLLTMedDRA10065898 Stomal nipple complicationLLTMedDRA10058933 Unspecified complication of colostomy and enterostomyLLTMedDRA10045671 C78321 E11721 Gastrointestinal stoma necrosis Gastroparesis 10018043 NCIA disorder characterized by an incomplete paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine. GastroparesisPTCTCAE C80512 E10759 Gastroparesis General disorders and administration site conditions 10018065 General disorders and administration site conditionsPTCTCAE E13873 General disorders and administration site conditions General disorders and administration site conditions - Other, specify General disorders and administration site conditions - Other, specifyPTCTCAE E11116 General disorders and administration site conditions - Other, specify Generalized muscle weakness 10062572 NCIA disorder characterized by a reduction in the strength of muscles in multiple anatomic sites. Generalised muscle weaknessLLTMedDRA10062571 Generalized muscle weaknessLLTMedDRA10062572 Generalized muscle weaknessPTCTCAE Hands weakness ofLLTMedDRA10019132 Localised muscle weaknessLLTMedDRA10059002 Localized muscle weaknessLLTMedDRA10059003 Lower extremities weakness ofLLTMedDRA10024947 Muscle weakness NOSLLTMedDRA10028351 Muscle weakness aggravatedLLTMedDRA10048391 Muscle weakness left-sidedLLTMedDRA10065780 Muscle weakness lower limbLLTMedDRA10065776 Muscle weakness right-sidedLLTMedDRA10065794 Muscle weakness trunkLLTMedDRA10065795 Muscle weakness upper limbLLTMedDRA10065895 Muscle weaknessLLTMedDRA10028350 Muscular weaknessLLTMedDRA10028372 MyastheniaLLTMedDRA10028415 Neuromuscular weaknessLLTMedDRA10062976 Weakness in extremityLLTMedDRA10065702 Weakness muscleLLTMedDRA10047867 Weakness of armsLLTMedDRA10050379 Weakness of limbsLLTMedDRA10047868 Weakness voluntary muscleLLTMedDRA10047870 C78323 E12418 Generalized muscle weakness Genital edema 10018146 NCIA disorder characterized by swelling due to an excessive accumulation of fluid in the genitals. Edema genitalLLTMedDRA10014224 Edema labial genitalLLTMedDRA10014227 Edema of male genital organsLLTMedDRA10014240 Genital edema femaleLLTMedDRA10054392 Genital edema maleLLTMedDRA10054393 Genital edemaLLTMedDRA10018146 Genital edemaPTCTCAE Genital oedema NOSLLTMedDRA10018164 Genital oedema femaleLLTMedDRA10018162 Genital oedema maleLLTMedDRA10018163 Oedema genitalLLTMedDRA10030104 Oedema labial genitalLLTMedDRA10055925 Oedema of male genital organsLLTMedDRA10055932 C78324 E13111 Genital edema Gingival pain 10018286 NCIA disorder characterized by a sensation of marked discomfort in the gingival region. Ache gumLLTMedDRA10049403 Burning gumLLTMedDRA10049400 Gingival painLLTMedDRA10018286 Gingival painPTCTCAE Gum painLLTMedDRA10018787 Irritation gumLLTMedDRA10049405 Pain gumLLTMedDRA10033404 Sensitivity of gumsLLTMedDRA10040011 Sore gumsLLTMedDRA10041359 Soreness gumLLTMedDRA10041371 Stinging gumLLTMedDRA10049401 Tender gumLLTMedDRA10049404 Throbbing gumLLTMedDRA10049402 C78325 E10763 Gingival pain Glaucoma 10018304 NCIA disorder characterized by an increase in pressure in the eyeball due to obstruction of the aqueous humor outflow. Corticosteroid-induced glaucoma, glaucomatous stageLLTMedDRA10011175 Corticosteroid-induced glaucoma, residual stageLLTMedDRA10011176 Corticosteroid-induced glaucomaLLTMedDRA10011174 Glaucoma (excl congenital)LLTMedDRA10018306 Glaucoma NOSLLTMedDRA10018326 Glaucoma aggravatedLLTMedDRA10048354 Glaucoma associated with unspecified ocular disorderLLTMedDRA10018320 Glaucoma both eyesLLTMedDRA10018322 Glaucoma of childhoodLLTMedDRA10018327 Glaucoma secondaryLLTMedDRA10018328 Glaucoma steroid-inducedLLTMedDRA10018329 Glaucoma, unspecifiedLLTMedDRA10018332 GlaucomaLLTMedDRA10018304 GlaucomaPTCTCAE Neovascular glaucomaLLTMedDRA10062891 Pseudoexfoliation glaucomaLLTMedDRA10037118 Secondary glaucomaLLTMedDRA10039831 Unspecified glaucomaLLTMedDRA10045894 C26782 E10392 Glaucoma Glossopharyngeal nerve disorder 10061185 NCIA disorder characterized by involvement of the glossopharyngeal nerve (ninth cranial nerve). Glossopharyngeal nerve disorder NOSLLTMedDRA10018389 Glossopharyngeal nerve disorderLLTMedDRA10061185 Glossopharyngeal nerve disorderPTCTCAE C27211 E12672 Glossopharyngeal nerve disorder Glucose intolerance 10052426 NCIA disorder characterized by an inability to properly metabolize glucose. Abnormal glucose toleranceLLTMedDRA10000137 Borderline diabetesLLTMedDRA10006026 Chemical diabetesLLTMedDRA10008423 Glucose intoleranceLLTMedDRA10052426 Glucose intolerancePTCTCAE Glucose tolerance abnormalLLTMedDRA10018426 Glucose tolerance impairedLLTMedDRA10018429 Latent diabetesLLTMedDRA10024016 Pre-diabetesLLTMedDRA10036481 Pre-diabeticLLTMedDRA10036482 PrediabetesLLTMedDRA10065542 Subclinical diabetesLLTMedDRA10042336 C34646 E12264 Glucose intolerance Grade 0 Adverse Event NCISign/symptom within normal limits Grade 0 Adverse EventPTCTCAE No Adverse EventSYCTCAE E10004 Grade 0 Adverse Event Grade 1 Abdominal distension NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Abdominal distensionPTCTCAE E10457 Grade 1 Abdominal distension Grade 1 Abdominal pain NCIMild pain Grade 1 Abdominal painPTCTCAE E10461 Grade 1 Abdominal pain Grade 1 Abducens nerve disorder NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Abducens nerve disorderPTCTCAE E12570 Grade 1 Abducens nerve disorder Grade 1 Accessory nerve disorder NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Accessory nerve disorderPTCTCAE E12574 Grade 1 Accessory nerve disorder Grade 1 Acidosis NCIpH <normal, but >=7.3 Grade 1 AcidosisPTCTCAE E12238 Grade 1 Acidosis Grade 1 Acoustic nerve disorder NOS NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Acoustic nerve disorder NOSPTCTCAE E12578 Grade 1 Acoustic nerve disorder NOS Grade 1 Activated partial thromboplastin time prolonged NCI>ULN - 1.5 x ULN Grade 1 Activated partial thromboplastin time prolongedPTCTCAE E12074 Grade 1 Activated partial thromboplastin time prolonged Grade 1 Acute kidney injury NCICreatinine level increase of >0.3 mg/dL; creatinine 1.5 - 2.0 x above baseline Grade 1 Acute kidney injuryPTCTCAE E12974 Grade 1 Acute kidney injury Grade 1 Adrenal insufficiency NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Adrenal insufficiencyPTCTCAE E10299 Grade 1 Adrenal insufficiency Grade 1 Adverse Event NCIAn adverse event that is asymptomatic, or involves mild or minor symptoms, or is of marginal clinical relevance, or consists of clinical or diagnostic observations alone, or where intervention is not indicated, or where only non-prescription intervention is indicated. Grade 1 Adverse EventPTCTCAE Mild Adverse EventSYCTCAE E10005 Grade 1 Adverse Event Grade 1 Agitation NCIMild mood alteration Grade 1 AgitationPTCTCAE E12875 Grade 1 Agitation Grade 1 Akathisia NCIMild restlessness or increased motor activity Grade 1 AkathisiaPTCTCAE E12582 Grade 1 Akathisia Grade 1 Alanine aminotransferase increased NCI>ULN - 3.0 x ULN Grade 1 Alanine aminotransferase increasedPTCTCAE E12078 Grade 1 Alanine aminotransferase increased Grade 1 Alkaline phosphatase increased NCI>ULN - 2.5 x ULN Grade 1 Alkaline phosphatase increasedPTCTCAE E12083 Grade 1 Alkaline phosphatase increased Grade 1 Alkalosis NCIpH >normal, but <=7.5 Grade 1 AlkalosisPTCTCAE E12248 Grade 1 Alkalosis Grade 1 Allergic reaction NCITransient flushing or rash, drug fever <38 degrees C (<100.4 degrees F); intervention not indicated Grade 1 Allergic reactionPTCTCAE E11249 Grade 1 Allergic reaction Grade 1 Allergic rhinitis NCIMild symptoms; intervention not indicated Grade 1 Allergic rhinitisPTCTCAE E13304 Grade 1 Allergic rhinitis Grade 1 Alopecia NCIHair loss of <50% of normal for that individual that is not obvious from a distance but only on close inspection; a different hair style may be required to cover the hair loss but it does not require a wig or hair piece to camouflage Grade 1 AlopeciaPTCTCAE E13612 Grade 1 Alopecia Grade 1 Amnesia NCIMild; transient memory loss Grade 1 AmnesiaPTCTCAE E12586 Grade 1 Amnesia Grade 1 Anal fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Anal fistulaPTCTCAE E10465 Grade 1 Anal fistula Grade 1 Anal hemorrhage NCIMild; intervention not indicated Grade 1 Anal hemorrhagePTCTCAE E10471 Grade 1 Anal hemorrhage Grade 1 Anal mucositis NCIAsymptomatic or mild symptoms; intervention not indicated Grade 1 Anal mucositisPTCTCAE E10477 Grade 1 Anal mucositis Grade 1 Anal pain NCIMild pain Grade 1 Anal painPTCTCAE E10487 Grade 1 Anal pain Grade 1 Anal stenosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Anal stenosisPTCTCAE E10491 Grade 1 Anal stenosis Grade 1 Anal ulcer NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Anal ulcerPTCTCAE E10497 Grade 1 Anal ulcer Grade 1 Anemia NCIHemoglobin (Hgb) <LLN - 10.0 g/dL; <LLN - 6.2 mmol/L; <LLN - 100 g/L Grade 1 AnemiaPTCTCAE E10011 Grade 1 Anemia Grade 1 Ankle fracture NCIMild; non-surgical intervention indicated Grade 1 Ankle fracturePTCTCAE E11641 Grade 1 Ankle fracture Grade 1 Anorectal infection NCILocalized; local intervention indicated Grade 1 Anorectal infectionPTCTCAE E11287 Grade 1 Anorectal infection Grade 1 Anorexia NCILoss of appetite without alteration in eating habits Grade 1 AnorexiaPTCTCAE E12253 Grade 1 Anorexia Grade 1 Anorgasmia NCIInability to achieve orgasm not adversely affecting relationship Grade 1 AnorgasmiaPTCTCAE E12881 Grade 1 Anorgasmia Grade 1 Anxiety NCIMild symptoms; intervention not indicated Grade 1 AnxietyPTCTCAE E12884 Grade 1 Anxiety Grade 1 Aortic valve disease NCIAsymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging Grade 1 Aortic valve diseasePTCTCAE E10072 Grade 1 Aortic valve disease Grade 1 Arachnoiditis NCIMild symptoms Grade 1 ArachnoiditisPTCTCAE E12592 Grade 1 Arachnoiditis Grade 1 Arterial injury NCIAsymptomatic diagnostic finding; intervention not indicated Grade 1 Arterial injuryPTCTCAE E11649 Grade 1 Arterial injury Grade 1 Arthralgia NCIMild pain Grade 1 ArthralgiaPTCTCAE E12375 Grade 1 Arthralgia Grade 1 Arthritis NCIMild pain with inflammation, erythema, or joint swelling Grade 1 ArthritisPTCTCAE E12379 Grade 1 Arthritis Grade 1 Ascites NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 AscitesPTCTCAE E10503 Grade 1 Ascites Grade 1 Aspartate aminotransferase increased NCI>ULN - 3.0 x ULN Grade 1 Aspartate aminotransferase increasedPTCTCAE E12088 Grade 1 Aspartate aminotransferase increased Grade 1 Aspiration NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 AspirationPTCTCAE E13311 Grade 1 Aspiration Grade 1 Asystole NCIPeriods of asystole; non-urgent medical management indicated Grade 1 AsystolePTCTCAE E10078 Grade 1 Asystole Grade 1 Ataxia NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 AtaxiaPTCTCAE E12598 Grade 1 Ataxia Grade 1 Atelectasis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 AtelectasisPTCTCAE E13317 Grade 1 Atelectasis Grade 1 Atrial fibrillation NCIAsymptomatic, intervention not indicated Grade 1 Atrial fibrillationPTCTCAE E10082 Grade 1 Atrial fibrillation Grade 1 Atrial flutter NCIAsymptomatic, intervention not indicated Grade 1 Atrial flutterPTCTCAE E10088 Grade 1 Atrial flutter Grade 1 Atrioventricular block first degree NCIAsymptomatic, intervention not indicated Grade 1 Atrioventricular block first degreePTCTCAE E10099 Grade 1 Atrioventricular block first degree Grade 1 Autoimmune disorder NCIAsymptomatic; serologic or other evidence of autoimmune reaction, with normal organ function; intervention not indicated Grade 1 Autoimmune disorderPTCTCAE E11259 Grade 1 Autoimmune disorder Grade 1 Avascular necrosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Avascular necrosisPTCTCAE E12383 Grade 1 Avascular necrosis Grade 1 Back pain NCIMild pain Grade 1 Back painPTCTCAE E12389 Grade 1 Back pain Grade 1 Bile duct stenosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Bile duct stenosisPTCTCAE E11174 Grade 1 Bile duct stenosis Grade 1 Biliary anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Biliary anastomotic leakPTCTCAE E11655 Grade 1 Biliary anastomotic leak Grade 1 Bladder anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Bladder anastomotic leakPTCTCAE E11661 Grade 1 Bladder anastomotic leak Grade 1 Bladder spasm NCIIntervention not indicated Grade 1 Bladder spasmPTCTCAE E12985 Grade 1 Bladder spasm Grade 1 Bloating NCINo change in bowel function or oral intake Grade 1 BloatingPTCTCAE E10509 Grade 1 Bloating Grade 1 Blood and lymphatic system disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Blood and lymphatic system disorders - Other, specifyPTCTCAE E10017 Grade 1 Blood and lymphatic system disorders - Other, specify Grade 1 Blood antidiuretic hormone abnormal NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Blood antidiuretic hormone abnormalPTCTCAE E12093 Grade 1 Blood antidiuretic hormone abnormal Grade 1 Blood bilirubin increased NCI>ULN - 1.5 x ULN Grade 1 Blood bilirubin increasedPTCTCAE E12097 Grade 1 Blood bilirubin increased Grade 1 Blood corticotrophin decreased NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Blood corticotrophin decreasedPTCTCAE E12102 Grade 1 Blood corticotrophin decreased Grade 1 Blood gonadotrophin abnormal NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Blood gonadotrophin abnormalPTCTCAE E12106 Grade 1 Blood gonadotrophin abnormal Grade 1 Blood prolactin abnormal NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Blood prolactin abnormalPTCTCAE E12110 Grade 1 Blood prolactin abnormal Grade 1 Blurred vision NCIIntervention not indicated Grade 1 Blurred visionPTCTCAE E10347 Grade 1 Blurred vision Grade 1 Body odor NCIMild odor; physician intervention not indicated; self care interventions Grade 1 Body odorPTCTCAE E13615 Grade 1 Body odor Grade 1 Bone marrow hypocellular NCIMildly hypocellular or <=25% reduction from normal cellularity for age Grade 1 Bone marrow hypocellularPTCTCAE E10023 Grade 1 Bone marrow hypocellular Grade 1 Bone pain NCIMild pain Grade 1 Bone painPTCTCAE E12393 Grade 1 Bone pain Grade 1 Brachial plexopathy NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Brachial plexopathyPTCTCAE E12602 Grade 1 Brachial plexopathy Grade 1 Breast atrophy NCIMinimal asymmetry; minimal atrophy Grade 1 Breast atrophyPTCTCAE E13070 Grade 1 Breast atrophy Grade 1 Breast pain NCIMild pain Grade 1 Breast painPTCTCAE E13074 Grade 1 Breast pain Grade 1 Bronchial fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Bronchial fistulaPTCTCAE E13323 Grade 1 Bronchial fistula Grade 1 Bronchial obstruction NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Bronchial obstructionPTCTCAE E13329 Grade 1 Bronchial obstruction Grade 1 Bronchial stricture NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Bronchial stricturePTCTCAE E13335 Grade 1 Bronchial stricture Grade 1 Bronchopleural fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Bronchopleural fistulaPTCTCAE E13341 Grade 1 Bronchopleural fistula Grade 1 Bronchopulmonary hemorrhage NCIMild symptoms; intervention not indicated Grade 1 Bronchopulmonary hemorrhagePTCTCAE E13347 Grade 1 Bronchopulmonary hemorrhage Grade 1 Bronchospasm NCIMild symptoms; intervention not indicated Grade 1 BronchospasmPTCTCAE E13353 Grade 1 Bronchospasm Grade 1 Bruising NCILocalized or in a dependent area Grade 1 BruisingPTCTCAE E11667 Grade 1 Bruising Grade 1 Bullous dermatitis NCIAsymptomatic; blisters covering <10% BSA Grade 1 Bullous dermatitisPTCTCAE E13618 Grade 1 Bullous dermatitis Grade 1 Burn NCIMinimal symptoms; intervention not indicated Grade 1 BurnPTCTCAE E11670 Grade 1 Burn Grade 1 Buttock pain NCIMild pain Grade 1 Buttock painPTCTCAE E12397 Grade 1 Buttock pain Grade 1 CD4 lymphocytes decreased NCI<LLN - 500/mm3; <LLN - 0.5 x 10e9 /L Grade 1 CD4 lymphocytes decreasedPTCTCAE E12123 Grade 1 CD4 lymphocytes decreased Grade 1 CPK increased NCI>ULN - 2.5 x ULN Grade 1 CPK increasedPTCTCAE E12133 Grade 1 CPK increased Grade 1 Carbon monoxide diffusing capacity decreased NCI3 - 5 units below LLN; for follow-up, a decrease of 3 - 5 units (ml/min/mm Hg) below the baseline value Grade 1 Carbon monoxide diffusing capacity decreasedPTCTCAE E12113 Grade 1 Carbon monoxide diffusing capacity decreased Grade 1 Cardiac disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Cardiac disorders - Other, specifyPTCTCAE E10105 Grade 1 Cardiac disorders - Other, specify Grade 1 Cardiac troponin I increased NCILevels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer Grade 1 Cardiac troponin I increasedPTCTCAE E12117 Grade 1 Cardiac troponin I increased Grade 1 Cardiac troponin T increased NCILevels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer Grade 1 Cardiac troponin T increasedPTCTCAE E12120 Grade 1 Cardiac troponin T increased Grade 1 Cataract NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 CataractPTCTCAE E10351 Grade 1 Cataract Grade 1 Cecal hemorrhage NCIMild; intervention not indicated Grade 1 Cecal hemorrhagePTCTCAE E10512 Grade 1 Cecal hemorrhage Grade 1 Central nervous system necrosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Central nervous system necrosisPTCTCAE E12606 Grade 1 Central nervous system necrosis Grade 1 Cerebrospinal fluid leakage NCIPost-craniotomy: asymptomatic; Post-lumbar puncture: transient headache; postural care indicated Grade 1 Cerebrospinal fluid leakagePTCTCAE E12612 Grade 1 Cerebrospinal fluid leakage Grade 1 Cheilitis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 CheilitisPTCTCAE E10518 Grade 1 Cheilitis Grade 1 Chest pain - cardiac NCIMild pain Grade 1 Chest pain - cardiacPTCTCAE E10111 Grade 1 Chest pain - cardiac Grade 1 Chest wall pain NCIMild pain Grade 1 Chest wall painPTCTCAE E12401 Grade 1 Chest wall pain Grade 1 Chills NCIMild sensation of cold; shivering; chattering of teeth Grade 1 ChillsPTCTCAE E11075 Grade 1 Chills Grade 1 Cholesterol high NCI>ULN - 300 mg/dL; >ULN - 7.75 mmol/L Grade 1 Cholesterol highPTCTCAE E12128 Grade 1 Cholesterol high Grade 1 Chronic kidney disease NCIeGFR (estimated Glomerular Filtration Rate) or CrCl (creatinine clearance) <LLN - 60 ml/min/1.73 m2 or proteinuria 2+ present; urine protein/creatinine >0.5 Grade 1 Chronic kidney diseasePTCTCAE E12989 Grade 1 Chronic kidney disease Grade 1 Chylothorax NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 ChylothoraxPTCTCAE E13359 Grade 1 Chylothorax Grade 1 Cognitive disturbance NCIMild cognitive disability; not interfering with work/school/life performance; specialized educational services/devices not indicated Grade 1 Cognitive disturbancePTCTCAE E12618 Grade 1 Cognitive disturbance Grade 1 Colitis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 ColitisPTCTCAE E10522 Grade 1 Colitis Grade 1 Colonic fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Colonic fistulaPTCTCAE E10528 Grade 1 Colonic fistula Grade 1 Colonic hemorrhage NCIMild; intervention not indicated Grade 1 Colonic hemorrhagePTCTCAE E10534 Grade 1 Colonic hemorrhage Grade 1 Colonic obstruction NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Colonic obstructionPTCTCAE E10540 Grade 1 Colonic obstruction Grade 1 Colonic stenosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Colonic stenosisPTCTCAE E10551 Grade 1 Colonic stenosis Grade 1 Colonic ulcer NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Colonic ulcerPTCTCAE E10557 Grade 1 Colonic ulcer Grade 1 Concentration impairment NCIMild inattention or decreased level of concentration Grade 1 Concentration impairmentPTCTCAE E12622 Grade 1 Concentration impairment Grade 1 Conduction disorder NCIMild symptoms; intervention not indicated Grade 1 Conduction disorderPTCTCAE E10115 Grade 1 Conduction disorder Grade 1 Confusion NCIMild disorientation Grade 1 ConfusionPTCTCAE E12890 Grade 1 Confusion Grade 1 Congenital, familial and genetic disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Congenital, familial and genetic disorders - Other, specifyPTCTCAE E10251 Grade 1 Congenital, familial and genetic disorders - Other, specify Grade 1 Conjunctivitis NCIAsymptomatic or mild symptoms; intervention not indicated Grade 1 ConjunctivitisPTCTCAE E10356 Grade 1 Conjunctivitis Grade 1 Constipation NCIOccasional or intermittent symptoms; occasional use of stool softeners, laxatives, dietary modification, or enema Grade 1 ConstipationPTCTCAE E10563 Grade 1 Constipation Grade 1 Cough NCIMild symptoms; nonprescription intervention indicated Grade 1 CoughPTCTCAE E13365 Grade 1 Cough Grade 1 Creatinine increased NCI>1 - 1.5 x baseline; >ULN - 1.5 x ULN Grade 1 Creatinine increasedPTCTCAE E12138 Grade 1 Creatinine increased Grade 1 Cushingoid NCIMild symptoms; intervention not indicated Grade 1 CushingoidPTCTCAE E10305 Grade 1 Cushingoid Grade 1 Cystitis noninfective NCIMicroscopic hematuria; minimal increase in frequency, urgency, dysuria, or nocturia; new onset of incontinence Grade 1 Cystitis noninfectivePTCTCAE E12995 Grade 1 Cystitis noninfective Grade 1 Cytokine release syndrome NCIMild reaction; infusion interruption not indicated; intervention not indicated Grade 1 Cytokine release syndromePTCTCAE E11265 Grade 1 Cytokine release syndrome Grade 1 Dehydration NCIIncreased oral fluids indicated; dry mucous membranes; diminished skin turgor Grade 1 DehydrationPTCTCAE E12259 Grade 1 Dehydration Grade 1 Delayed orgasm NCIDelay in achieving orgasm not adversely affecting relationship Grade 1 Delayed orgasmPTCTCAE E12896 Grade 1 Delayed orgasm Grade 1 Delirium NCIMild acute confusional state Grade 1 DeliriumPTCTCAE E12899 Grade 1 Delirium Grade 1 Dental caries NCIOne or more dental caries, not involving the root Grade 1 Dental cariesPTCTCAE E10569 Grade 1 Dental caries Grade 1 Depressed level of consciousness NCIDecreased level of alertness Grade 1 Depressed level of consciousnessPTCTCAE E12626 Grade 1 Depressed level of consciousness Grade 1 Depression NCIMild depressive symptoms Grade 1 DepressionPTCTCAE E12910 Grade 1 Depression Grade 1 Dermatitis radiation NCIFaint erythema or dry desquamation Grade 1 Dermatitis radiationPTCTCAE E11676 Grade 1 Dermatitis radiation Grade 1 Diarrhea NCIIncrease of <4 stools per day over baseline; mild increase in ostomy output compared to baseline Grade 1 DiarrheaPTCTCAE E10573 Grade 1 Diarrhea Grade 1 Dizziness NCIMild unsteadiness or sensation of movement Grade 1 DizzinessPTCTCAE E12632 Grade 1 Dizziness Grade 1 Dry eye NCIAsymptomatic; clinical or diagnostic observations only; mild symptoms relieved by lubricants Grade 1 Dry eyePTCTCAE E10364 Grade 1 Dry eye Grade 1 Dry mouth NCISymptomatic (e.g., dry or thick saliva) without significant dietary alteration; unstimulated saliva flow >0.2 ml/min Grade 1 Dry mouthPTCTCAE E10579 Grade 1 Dry mouth Grade 1 Dry skin NCICovering <10% BSA and no associated erythema or pruritus Grade 1 Dry skinPTCTCAE E13624 Grade 1 Dry skin Grade 1 Duodenal fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Duodenal fistulaPTCTCAE E10583 Grade 1 Duodenal fistula Grade 1 Duodenal hemorrhage NCIMild; intervention not indicated Grade 1 Duodenal hemorrhagePTCTCAE E10589 Grade 1 Duodenal hemorrhage Grade 1 Duodenal obstruction NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Duodenal obstructionPTCTCAE E10595 Grade 1 Duodenal obstruction Grade 1 Duodenal stenosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Duodenal stenosisPTCTCAE E10606 Grade 1 Duodenal stenosis Grade 1 Duodenal ulcer NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Duodenal ulcerPTCTCAE E10612 Grade 1 Duodenal ulcer Grade 1 Dysarthria NCIMild slurred speech Grade 1 DysarthriaPTCTCAE E12636 Grade 1 Dysarthria Grade 1 Dysesthesia NCIMild sensory alteration Grade 1 DysesthesiaPTCTCAE E12640 Grade 1 Dysesthesia Grade 1 Dysgeusia NCIAltered taste but no change in diet Grade 1 DysgeusiaPTCTCAE E12644 Grade 1 Dysgeusia Grade 1 Dysmenorrhea NCIMild symptoms; intervention not indicated Grade 1 DysmenorrheaPTCTCAE E13078 Grade 1 Dysmenorrhea Grade 1 Dyspareunia NCIMild discomfort or pain associated with vaginal penetration; discomfort relieved with use of vaginal lubricants or estrogen Grade 1 DyspareuniaPTCTCAE E13082 Grade 1 Dyspareunia Grade 1 Dyspepsia NCIMild symptoms; intervention not indicated Grade 1 DyspepsiaPTCTCAE E10618 Grade 1 Dyspepsia Grade 1 Dysphagia NCISymptomatic, able to eat regular diet Grade 1 DysphagiaPTCTCAE E10622 Grade 1 Dysphagia Grade 1 Dysphasia NCIAwareness of receptive or expressive characteristics; not impairing ability to communicate Grade 1 DysphasiaPTCTCAE E12647 Grade 1 Dysphasia Grade 1 Dyspnea NCIShortness of breath with moderate exertion Grade 1 DyspneaPTCTCAE E13369 Grade 1 Dyspnea Grade 1 Ear and labyrinth disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Ear and labyrinth disorders - Other, specifyPTCTCAE E10257 Grade 1 Ear and labyrinth disorders - Other, specify Grade 1 Ear pain NCIMild pain Grade 1 Ear painPTCTCAE E10263 Grade 1 Ear pain Grade 1 Edema face NCILocalized facial edema Grade 1 Edema facePTCTCAE E11083 Grade 1 Edema face Grade 1 Edema limbs NCI5 - 10% inter-limb discrepancy in volume or circumference at point of greatest visible difference; swelling or obscuration of anatomic architecture on close inspection Grade 1 Edema limbsPTCTCAE E11087 Grade 1 Edema limbs Grade 1 Edema trunk NCISwelling or obscuration of anatomic architecture on close inspection Grade 1 Edema trunkPTCTCAE E11091 Grade 1 Edema trunk Grade 1 Ejaculation disorder NCIDiminished ejaculation Grade 1 Ejaculation disorderPTCTCAE E13086 Grade 1 Ejaculation disorder Grade 1 Electrocardiogram QT corrected interval prolonged NCIQTc 450 - 480 ms Grade 1 Electrocardiogram QT corrected interval prolongedPTCTCAE E12147 Grade 1 Electrocardiogram QT corrected interval prolonged Grade 1 Encephalopathy NCIMild symptoms Grade 1 EncephalopathyPTCTCAE E12653 Grade 1 Encephalopathy Grade 1 Endocrine disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Endocrine disorders - Other, specifyPTCTCAE E10312 Grade 1 Endocrine disorders - Other, specify Grade 1 Enterocolitis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 EnterocolitisPTCTCAE E10628 Grade 1 Enterocolitis Grade 1 Enterovesical fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Enterovesical fistulaPTCTCAE E10634 Grade 1 Enterovesical fistula Grade 1 Epistaxis NCIMild symptoms; intervention not indicated Grade 1 EpistaxisPTCTCAE E13375 Grade 1 Epistaxis Grade 1 Erectile dysfunction NCIDecrease in erectile function (frequency or rigidity of erections) but intervention not indicated (e.g., medication or use of mechanical device, penile pump) Grade 1 Erectile dysfunctionPTCTCAE E13089 Grade 1 Erectile dysfunction Grade 1 Erythema multiforme NCITarget lesions covering <10% BSA and not associated with skin tenderness Grade 1 Erythema multiformePTCTCAE E13628 Grade 1 Erythema multiforme Grade 1 Esophageal anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Esophageal anastomotic leakPTCTCAE E11682 Grade 1 Esophageal anastomotic leak Grade 1 Esophageal fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Esophageal fistulaPTCTCAE E10640 Grade 1 Esophageal fistula Grade 1 Esophageal hemorrhage NCIMild; intervention not indicated Grade 1 Esophageal hemorrhagePTCTCAE E10646 Grade 1 Esophageal hemorrhage Grade 1 Esophageal obstruction NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Esophageal obstructionPTCTCAE E10656 Grade 1 Esophageal obstruction Grade 1 Esophageal pain NCIMild pain Grade 1 Esophageal painPTCTCAE E10662 Grade 1 Esophageal pain Grade 1 Esophageal stenosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Esophageal stenosisPTCTCAE E10671 Grade 1 Esophageal stenosis Grade 1 Esophageal ulcer NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Esophageal ulcerPTCTCAE E10677 Grade 1 Esophageal ulcer Grade 1 Esophagitis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 EsophagitisPTCTCAE E10688 Grade 1 Esophagitis Grade 1 Euphoria NCIMild mood elevation Grade 1 EuphoriaPTCTCAE E12916 Grade 1 Euphoria Grade 1 Exostosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 ExostosisPTCTCAE E12405 Grade 1 Exostosis Grade 1 External ear inflammation NCIExternal otitis with erythema or dry desquamation Grade 1 External ear inflammationPTCTCAE E10267 Grade 1 External ear inflammation Grade 1 External ear pain NCIMild pain Grade 1 External ear painPTCTCAE E10273 Grade 1 External ear pain Grade 1 Extraocular muscle paresis NCIAsymptomatic; clinical or diagnostic observations only Grade 1 Extraocular muscle paresisPTCTCAE E10368 Grade 1 Extraocular muscle paresis Grade 1 Extrapyramidal disorder NCIMild involuntary movements Grade 1 Extrapyramidal disorderPTCTCAE E12659 Grade 1 Extrapyramidal disorder Grade 1 Eye disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Eye disorders - Other, specifyPTCTCAE E10372 Grade 1 Eye disorders - Other, specify Grade 1 Eye pain NCIMild pain Grade 1 Eye painPTCTCAE E10377 Grade 1 Eye pain Grade 1 Eyelid function disorder NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Eyelid function disorderPTCTCAE E10381 Grade 1 Eyelid function disorder Grade 1 Facial muscle weakness NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Facial muscle weaknessPTCTCAE E12665 Grade 1 Facial muscle weakness Grade 1 Facial nerve disorder NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Facial nerve disorderPTCTCAE E12669 Grade 1 Facial nerve disorder Grade 1 Facial pain NCIMild pain Grade 1 Facial painPTCTCAE E11095 Grade 1 Facial pain Grade 1 Fall NCIMinor with no resultant injuries; intervention not indicated Grade 1 FallPTCTCAE E11688 Grade 1 Fall Grade 1 Fallopian tube anastomotic leak NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Fallopian tube anastomotic leakPTCTCAE E11692 Grade 1 Fallopian tube anastomotic leak Grade 1 Fallopian tube obstruction NCIDiagnostic observations only; intervention not indicated Grade 1 Fallopian tube obstructionPTCTCAE E13093 Grade 1 Fallopian tube obstruction Grade 1 Fallopian tube perforation NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Fallopian tube perforationPTCTCAE E11698 Grade 1 Fallopian tube perforation Grade 1 Fallopian tube stenosis NCIAsymptomatic clinical or diagnostic observations only; intervention not indicated Grade 1 Fallopian tube stenosisPTCTCAE E13097 Grade 1 Fallopian tube stenosis Grade 1 Fat atrophy NCICovering <10% BSA and asymptomatic Grade 1 Fat atrophyPTCTCAE E13639 Grade 1 Fat atrophy Grade 1 Fatigue NCIFatigue relieved by rest Grade 1 FatiguePTCTCAE E11099 Grade 1 Fatigue Grade 1 Fecal incontinence NCIOccasional use of pads required Grade 1 Fecal incontinencePTCTCAE E10694 Grade 1 Fecal incontinence Grade 1 Female genital tract fistula NCIAsymptomatic clinical or diagnostic observations only; intervention not indicated Grade 1 Female genital tract fistulaPTCTCAE E13103 Grade 1 Female genital tract fistula Grade 1 Feminization acquired NCIMild symptoms; intervention not indicated Grade 1 Feminization acquiredPTCTCAE E13109 Grade 1 Feminization acquired Grade 1 Fever NCI38.0 - 39.0 degrees C (100.4 - 102.2 degrees F) Grade 1 FeverPTCTCAE E11103 Grade 1 Fever Grade 1 Fibrinogen decreased NCI<1.0 - 0.75 x LLN or <25% decrease from baseline Grade 1 Fibrinogen decreasedPTCTCAE E12152 Grade 1 Fibrinogen decreased Grade 1 Fibrosis deep connective tissue NCIMild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up) Grade 1 Fibrosis deep connective tissuePTCTCAE E12409 Grade 1 Fibrosis deep connective tissue Grade 1 Flank pain NCIMild pain Grade 1 Flank painPTCTCAE E12415 Grade 1 Flank pain Grade 1 Flashing lights NCISymptomatic but not limiting ADL Grade 1 Flashing lightsPTCTCAE E10385 Grade 1 Flashing lights Grade 1 Flatulence NCIMild symptoms; intervention not indicated Grade 1 FlatulencePTCTCAE E10698 Grade 1 Flatulence Grade 1 Floaters NCISymptomatic but not limiting ADL Grade 1 FloatersPTCTCAE E10389 Grade 1 Floaters Grade 1 Flu like symptoms NCIMild flu-like symptoms present Grade 1 Flu like symptomsPTCTCAE E11109 Grade 1 Flu like symptoms Grade 1 Flushing NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 FlushingPTCTCAE E13772 Grade 1 Flushing Grade 1 Forced expiratory volume decreased NCIFEV1% (percentages of observed FEV1 and FVC related to their respective predicted values) 99 - 70% predicted Grade 1 Forced expiratory volume decreasedPTCTCAE E12157 Grade 1 Forced expiratory volume decreased Grade 1 Fracture NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 FracturePTCTCAE E11704 Grade 1 Fracture Grade 1 GGT increased NCI>ULN - 2.5 x ULN Grade 1 GGT increasedPTCTCAE E12162 Grade 1 GGT increased Grade 1 Gait disturbance NCIMild change in gait (e.g., wide-based, limping or hobbling) Grade 1 Gait disturbancePTCTCAE E11113 Grade 1 Gait disturbance Grade 1 Gallbladder fistula NCIAsymptomatic clinical or diagnostic observations only; intervention not indicated Grade 1 Gallbladder fistulaPTCTCAE E11190 Grade 1 Gallbladder fistula Grade 1 Gallbladder obstruction NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Gallbladder obstructionPTCTCAE E11199 Grade 1 Gallbladder obstruction Grade 1 Gallbladder pain NCIMild pain Grade 1 Gallbladder painPTCTCAE E11205 Grade 1 Gallbladder pain Grade 1 Gastric anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Gastric anastomotic leakPTCTCAE E11710 Grade 1 Gastric anastomotic leak Grade 1 Gastric fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Gastric fistulaPTCTCAE E10701 Grade 1 Gastric fistula Grade 1 Gastric hemorrhage NCIMild; intervention not indicated Grade 1 Gastric hemorrhagePTCTCAE E10707 Grade 1 Gastric hemorrhage Grade 1 Gastric stenosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Gastric stenosisPTCTCAE E10722 Grade 1 Gastric stenosis Grade 1 Gastric ulcer NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Gastric ulcerPTCTCAE E10728 Grade 1 Gastric ulcer Grade 1 Gastritis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 GastritisPTCTCAE E10734 Grade 1 Gastritis Grade 1 Gastroesophageal reflux disease NCIMild symptoms; intervention not indicated Grade 1 Gastroesophageal reflux diseasePTCTCAE E10740 Grade 1 Gastroesophageal reflux disease Grade 1 Gastrointestinal anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Gastrointestinal anastomotic leakPTCTCAE E11716 Grade 1 Gastrointestinal anastomotic leak Grade 1 Gastrointestinal disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Gastrointestinal disorders - Other, specifyPTCTCAE E10744 Grade 1 Gastrointestinal disorders - Other, specify Grade 1 Gastrointestinal fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Gastrointestinal fistulaPTCTCAE E10750 Grade 1 Gastrointestinal fistula Grade 1 Gastrointestinal pain NCIMild pain Grade 1 Gastrointestinal painPTCTCAE E10756 Grade 1 Gastrointestinal pain Grade 1 Gastroparesis NCIMild nausea, early satiety and bloating, able to maintain caloric intake on regular diet Grade 1 GastroparesisPTCTCAE E10760 Grade 1 Gastroparesis Grade 1 General disorders and administration site conditions - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 General disorders and administration site conditions - Other, specifyPTCTCAE E11117 Grade 1 General disorders and administration site conditions - Other, specify Grade 1 Generalized muscle weakness NCISymptomatic; weakness perceived by patient but not evident on physical exam Grade 1 Generalized muscle weaknessPTCTCAE E12419 Grade 1 Generalized muscle weakness Grade 1 Genital edema NCIMild swelling or obscuration of anatomic architecture on close inspection Grade 1 Genital edemaPTCTCAE E13112 Grade 1 Genital edema Grade 1 Gingival pain NCIMild pain Grade 1 Gingival painPTCTCAE E10764 Grade 1 Gingival pain Grade 1 Glaucoma NCIElevated intraocular pressure (EIOP) with single topical agent for intervention; no visual field deficit Grade 1 GlaucomaPTCTCAE E10393 Grade 1 Glaucoma Grade 1 Glossopharyngeal nerve disorder NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Glossopharyngeal nerve disorderPTCTCAE E12673 Grade 1 Glossopharyngeal nerve disorder Grade 1 Glucose intolerance NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Glucose intolerancePTCTCAE E12265 Grade 1 Glucose intolerance Grade 1 Growth hormone abnormal NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Growth hormone abnormalPTCTCAE E12167 Grade 1 Growth hormone abnormal Grade 1 Growth suppression NCIReduction in growth velocity by 10 - 29% ideally measured over the period of a year Grade 1 Growth suppressionPTCTCAE E12423 Grade 1 Growth suppression Grade 1 Gum infection NCILocal therapy indicated (swish and swallow) Grade 1 Gum infectionPTCTCAE E11401 Grade 1 Gum infection Grade 1 Gynecomastia NCIAsymptomatic breast enlargement Grade 1 GynecomastiaPTCTCAE E13116 Grade 1 Gynecomastia Grade 1 Hallucinations NCIMild hallucinations (e.g., perceptual distortions) Grade 1 HallucinationsPTCTCAE E12920 Grade 1 Hallucinations Grade 1 Haptoglobin decreased NCI<LLN Grade 1 Haptoglobin decreasedPTCTCAE E12170 Grade 1 Haptoglobin decreased Grade 1 Headache NCIMild pain Grade 1 HeadachePTCTCAE E12679 Grade 1 Headache Grade 1 Hearing impaired NCIAdults enrolled on a Monitoring Program (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift of 15 - 25 dB averaged at 2 contiguous test frequencies in at least one ear. Adults not enrolled in Monitoring Program: subjective change in hearing in the absence of documented hearing loss. Pediatric (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift >20 dB at 8 kHz in at least one ear. Grade 1 Hearing impairedPTCTCAE E10277 Grade 1 Hearing impaired Grade 1 Heart failure NCIAsymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities Grade 1 Heart failurePTCTCAE E10125 Grade 1 Heart failure Grade 1 Hematoma NCIMild symptoms; intervention not indicated Grade 1 HematomaPTCTCAE E13776 Grade 1 Hematoma Grade 1 Hematosalpinx NCIMinimal bleeding identified on imaging study or laparoscopy; intervention not indicated Grade 1 HematosalpinxPTCTCAE E13120 Grade 1 Hematosalpinx Grade 1 Hematuria NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 HematuriaPTCTCAE E13001 Grade 1 Hematuria Grade 1 Hemoglobin increased NCIIncrease in >0 - 2 gm/dL above ULN or above baseline if baseline is above ULN Grade 1 Hemoglobin increasedPTCTCAE E12172 Grade 1 Hemoglobin increased Grade 1 Hemoglobinuria NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 HemoglobinuriaPTCTCAE E13007 Grade 1 Hemoglobinuria Grade 1 Hemolysis NCILaboratory evidence of hemolysis only (e.g., direct antiglobulin test; DAT; Coombs'; schistocytes; decreased haptoglobin) Grade 1 HemolysisPTCTCAE E10038 Grade 1 Hemolysis Grade 1 Hemolytic uremic syndrome NCIEvidence of RBC destruction (schistocytosis) without clinical consequences Grade 1 Hemolytic uremic syndromePTCTCAE E10044 Grade 1 Hemolytic uremic syndrome Grade 1 Hemorrhoidal hemorrhage NCIMild; intervention not indicated Grade 1 Hemorrhoidal hemorrhagePTCTCAE E10768 Grade 1 Hemorrhoidal hemorrhage Grade 1 Hemorrhoids NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 HemorrhoidsPTCTCAE E10774 Grade 1 Hemorrhoids Grade 1 Hepatic hemorrhage NCIMild; intervention not indicated Grade 1 Hepatic hemorrhagePTCTCAE E11216 Grade 1 Hepatic hemorrhage Grade 1 Hepatic pain NCIMild pain Grade 1 Hepatic painPTCTCAE E11225 Grade 1 Hepatic pain Grade 1 Hepatitis viral NCIAsymptomatic, treatment not indicated Grade 1 Hepatitis viralPTCTCAE E11411 Grade 1 Hepatitis viral Grade 1 Hepatobiliary disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Hepatobiliary disorders - Other, specifyPTCTCAE E11229 Grade 1 Hepatobiliary disorders - Other, specify Grade 1 Hiccups NCIMild symptoms; intervention not indicated Grade 1 HiccupsPTCTCAE E13381 Grade 1 Hiccups Grade 1 Hirsutism NCIIn women, increase in length, thickness or density of hair in a male distribution that the patient is able to camouflage by periodic shaving, bleaching, or removal of hair Grade 1 HirsutismPTCTCAE E13643 Grade 1 Hirsutism Grade 1 Hoarseness NCIMild or intermittent voice change; fully understandable; self-resolves Grade 1 HoarsenessPTCTCAE E13385 Grade 1 Hoarseness Grade 1 Hot flashes NCIMild symptoms; intervention not indicated Grade 1 Hot flashesPTCTCAE E13782 Grade 1 Hot flashes Grade 1 Hydrocephalus NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 HydrocephalusPTCTCAE E12683 Grade 1 Hydrocephalus Grade 1 Hypercalcemia NCICorrected serum calcium of >ULN - 11.5 mg/dL; >ULN - 2.9 mmol/L; Ionized calcium >ULN - 1.5 mmol/L Grade 1 HypercalcemiaPTCTCAE E12271 Grade 1 Hypercalcemia Grade 1 Hyperglycemia NCIFasting glucose value >ULN - 160 mg/dL; Fasting glucose value >ULN - 8.9 mmol/L Grade 1 HyperglycemiaPTCTCAE E12277 Grade 1 Hyperglycemia Grade 1 Hyperhidrosis NCILimited to one site (palms, soles, or axillae); self care interventions Grade 1 HyperhidrosisPTCTCAE E13646 Grade 1 Hyperhidrosis Grade 1 Hyperkalemia NCI>ULN - 5.5 mmol/L Grade 1 HyperkalemiaPTCTCAE E12283 Grade 1 Hyperkalemia Grade 1 Hypermagnesemia NCI>ULN - 3.0 mg/dL; >ULN - 1.23 mmol/L Grade 1 HypermagnesemiaPTCTCAE E12289 Grade 1 Hypermagnesemia Grade 1 Hypernatremia NCI>ULN - 150 mmol/L Grade 1 HypernatremiaPTCTCAE E12294 Grade 1 Hypernatremia Grade 1 Hyperparathyroidism NCIMild symptoms; intervention not indicated Grade 1 HyperparathyroidismPTCTCAE E10320 Grade 1 Hyperparathyroidism Grade 1 Hypersomnia NCIMild increased need for sleep Grade 1 HypersomniaPTCTCAE E12689 Grade 1 Hypersomnia Grade 1 Hypertension NCIPrehypertension (systolic BP 120 - 139 mm Hg or diastolic BP 80 - 89 mm Hg) Grade 1 HypertensionPTCTCAE E13786 Grade 1 Hypertension Grade 1 Hyperthyroidism NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 HyperthyroidismPTCTCAE E10323 Grade 1 Hyperthyroidism Grade 1 Hypertrichosis NCIIncrease in length, thickness or density of hair that the patient is either able to camouflage by periodic shaving or removal of hairs or is not concerned enough about the overgrowth to use any form of hair removal Grade 1 HypertrichosisPTCTCAE E13650 Grade 1 Hypertrichosis Grade 1 Hypertriglyceridemia NCI150 mg/dL - 300 mg/dL; 1.71 mmol/L - 3.42 mmol/L Grade 1 HypertriglyceridemiaPTCTCAE E12300 Grade 1 Hypertriglyceridemia Grade 1 Hyperuricemia NCI>ULN - 10 mg/dL (0.59 mmol/L) without physiologic consequences Grade 1 HyperuricemiaPTCTCAE E12306 Grade 1 Hyperuricemia Grade 1 Hypoalbuminemia NCI<LLN - 3 g/dL; <LLN - 30 g/L Grade 1 HypoalbuminemiaPTCTCAE E12311 Grade 1 Hypoalbuminemia Grade 1 Hypocalcemia NCICorrected serum calcium of <LLN - 8.0 mg/dL; <LLN - 2.0 mmol/L; Ionized calcium <LLN - 1.0 mmol/L Grade 1 HypocalcemiaPTCTCAE E12317 Grade 1 Hypocalcemia Grade 1 Hypoglossal nerve disorder NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Hypoglossal nerve disorderPTCTCAE E12693 Grade 1 Hypoglossal nerve disorder Grade 1 Hypoglycemia NCI<LLN - 55 mg/dL; <LLN - 3.0 mmol/L Grade 1 HypoglycemiaPTCTCAE E12323 Grade 1 Hypoglycemia Grade 1 Hypokalemia NCI<LLN - 3.0 mmol/L Grade 1 HypokalemiaPTCTCAE E12328 Grade 1 Hypokalemia Grade 1 Hypomagnesemia NCI<LLN - 1.2 mg/dL; <LLN - 0.5 mmol/L Grade 1 HypomagnesemiaPTCTCAE E12334 Grade 1 Hypomagnesemia Grade 1 Hyponatremia NCI<LLN - 130 mmol/L Grade 1 HyponatremiaPTCTCAE E12340 Grade 1 Hyponatremia Grade 1 Hypoparathyroidism NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 HypoparathyroidismPTCTCAE E10329 Grade 1 Hypoparathyroidism Grade 1 Hypophosphatemia NCI<LLN - 2.5 mg/dL; <LLN - 0.8 mmol/L Grade 1 HypophosphatemiaPTCTCAE E12345 Grade 1 Hypophosphatemia Grade 1 Hypotension NCIAsymptomatic, intervention not indicated Grade 1 HypotensionPTCTCAE E13792 Grade 1 Hypotension Grade 1 Hypothyroidism NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 HypothyroidismPTCTCAE E10335 Grade 1 Hypothyroidism Grade 1 INR increased NCI>1 - 1.5 x ULN; >1 - 1.5 times above baseline if on anticoagulation Grade 1 INR increasedPTCTCAE E12176 Grade 1 INR increased Grade 1 IVth nerve disorder NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 IVth nerve disorderPTCTCAE E12706 Grade 1 IVth nerve disorder Grade 1 Ileal fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Ileal fistulaPTCTCAE E10778 Grade 1 Ileal fistula Grade 1 Ileal hemorrhage NCIMild; intervention not indicated Grade 1 Ileal hemorrhagePTCTCAE E10784 Grade 1 Ileal hemorrhage Grade 1 Ileal obstruction NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Ileal obstructionPTCTCAE E10790 Grade 1 Ileal obstruction Grade 1 Ileal stenosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Ileal stenosisPTCTCAE E10801 Grade 1 Ileal stenosis Grade 1 Ileal ulcer NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Ileal ulcerPTCTCAE E10807 Grade 1 Ileal ulcer Grade 1 Immune system disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Immune system disorders - Other, specifyPTCTCAE E11271 Grade 1 Immune system disorders - Other, specify Grade 1 Infections and infestations - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Infections and infestations - Other, specifyPTCTCAE E11416 Grade 1 Infections and infestations - Other, specify Grade 1 Infusion related reaction NCIMild transient reaction; infusion interruption not indicated; intervention not indicated Grade 1 Infusion related reactionPTCTCAE E11128 Grade 1 Infusion related reaction Grade 1 Injection site reaction NCITenderness with or without associated symptoms (e.g., warmth, erythema, itching) Grade 1 Injection site reactionPTCTCAE E11139 Grade 1 Injection site reaction Grade 1 Injury, poisoning and procedural complications - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Injury, poisoning and procedural complications - Other, specifyPTCTCAE E11748 Grade 1 Injury, poisoning and procedural complications - Other, specify Grade 1 Injury to superior vena cava NCIAsymptomatic diagnostic finding; intervention not indicated Grade 1 Injury to superior vena cavaPTCTCAE E11742 Grade 1 Injury to superior vena cava Grade 1 Insomnia NCIMild difficulty falling asleep, staying asleep or waking up early Grade 1 InsomniaPTCTCAE E12926 Grade 1 Insomnia Grade 1 Intestinal stoma leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Intestinal stoma leakPTCTCAE E11754 Grade 1 Intestinal stoma leak Grade 1 Intestinal stoma site bleeding NCIMinimal bleeding identified on clinical exam; intervention not indicated Grade 1 Intestinal stoma site bleedingPTCTCAE E11765 Grade 1 Intestinal stoma site bleeding Grade 1 Intracranial hemorrhage NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Intracranial hemorrhagePTCTCAE E12697 Grade 1 Intracranial hemorrhage Grade 1 Intraoperative arterial injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative arterial injuryPTCTCAE E11771 Grade 1 Intraoperative arterial injury Grade 1 Intraoperative breast injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative breast injuryPTCTCAE E11777 Grade 1 Intraoperative breast injury Grade 1 Intraoperative ear injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative ear injuryPTCTCAE E11787 Grade 1 Intraoperative ear injury Grade 1 Intraoperative endocrine injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative endocrine injuryPTCTCAE E11793 Grade 1 Intraoperative endocrine injury Grade 1 Intraoperative gastrointestinal injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative gastrointestinal injuryPTCTCAE E11799 Grade 1 Intraoperative gastrointestinal injury Grade 1 Intraoperative head and neck injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative head and neck injuryPTCTCAE E11805 Grade 1 Intraoperative head and neck injury Grade 1 Intraoperative hepatobiliary injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative hepatobiliary injuryPTCTCAE E11815 Grade 1 Intraoperative hepatobiliary injury Grade 1 Intraoperative musculoskeletal injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative musculoskeletal injuryPTCTCAE E11821 Grade 1 Intraoperative musculoskeletal injury Grade 1 Intraoperative neurological injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative neurological injuryPTCTCAE E11827 Grade 1 Intraoperative neurological injury Grade 1 Intraoperative ocular injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative ocular injuryPTCTCAE E11833 Grade 1 Intraoperative ocular injury Grade 1 Intraoperative renal injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative renal injuryPTCTCAE E11839 Grade 1 Intraoperative renal injury Grade 1 Intraoperative reproductive tract injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative reproductive tract injuryPTCTCAE E11845 Grade 1 Intraoperative reproductive tract injury Grade 1 Intraoperative respiratory injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative respiratory injuryPTCTCAE E11851 Grade 1 Intraoperative respiratory injury Grade 1 Intraoperative skin injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative skin injuryPTCTCAE E11857 Grade 1 Intraoperative skin injury Grade 1 Intraoperative urinary injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative urinary injuryPTCTCAE E11868 Grade 1 Intraoperative urinary injury Grade 1 Intraoperative venous injury NCIPrimary repair of injured organ/structure indicated Grade 1 Intraoperative venous injuryPTCTCAE E11874 Grade 1 Intraoperative venous injury Grade 1 Investigations - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Investigations - Other, specifyPTCTCAE E12180 Grade 1 Investigations - Other, specify Grade 1 Irregular menstruation NCIIntermittent menses with skipped menses for no more than 1 to 3 months Grade 1 Irregular menstruationPTCTCAE E13126 Grade 1 Irregular menstruation Grade 1 Irritability NCIMild; easily consolable Grade 1 IrritabilityPTCTCAE E11145 Grade 1 Irritability Grade 1 Ischemia cerebrovascular NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Ischemia cerebrovascularPTCTCAE E12703 Grade 1 Ischemia cerebrovascular Grade 1 Jejunal fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Jejunal fistulaPTCTCAE E10823 Grade 1 Jejunal fistula Grade 1 Jejunal hemorrhage NCIMild; intervention not indicated Grade 1 Jejunal hemorrhagePTCTCAE E10829 Grade 1 Jejunal hemorrhage Grade 1 Jejunal obstruction NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Jejunal obstructionPTCTCAE E10835 Grade 1 Jejunal obstruction Grade 1 Jejunal stenosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Jejunal stenosisPTCTCAE E10846 Grade 1 Jejunal stenosis Grade 1 Jejunal ulcer NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Jejunal ulcerPTCTCAE E10852 Grade 1 Jejunal ulcer Grade 1 Joint effusion NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Joint effusionPTCTCAE E12432 Grade 1 Joint effusion Grade 1 Joint range of motion decreased NCI<=25% loss of ROM (range of motion); decreased ROM limiting athletic activity Grade 1 Joint range of motion decreasedPTCTCAE E12436 Grade 1 Joint range of motion decreased Grade 1 Joint range of motion decreased cervical spine NCIMild restriction of rotation or flexion between 60 - 70 degrees Grade 1 Joint range of motion decreased cervical spinePTCTCAE E12440 Grade 1 Joint range of motion decreased cervical spine Grade 1 Joint range of motion decreased lumbar spine NCIStiffness; difficulty bending to the floor to pick up a very light object but able to do athletic activity Grade 1 Joint range of motion decreased lumbar spinePTCTCAE E12444 Grade 1 Joint range of motion decreased lumbar spine Grade 1 Kidney anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Kidney anastomotic leakPTCTCAE E11880 Grade 1 Kidney anastomotic leak Grade 1 Kyphosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 KyphosisPTCTCAE E12448 Grade 1 Kyphosis Grade 1 Lactation disorder NCIMild changes in lactation, not significantly affecting production or expression of breast milk Grade 1 Lactation disorderPTCTCAE E13130 Grade 1 Lactation disorder Grade 1 Large intestinal anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Large intestinal anastomotic leakPTCTCAE E11886 Grade 1 Large intestinal anastomotic leak Grade 1 Laryngeal edema NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Laryngeal edemaPTCTCAE E13394 Grade 1 Laryngeal edema Grade 1 Laryngeal fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Laryngeal fistulaPTCTCAE E13400 Grade 1 Laryngeal fistula Grade 1 Laryngeal hemorrhage NCIMild cough or trace hemoptysis; laryngoscopic findings Grade 1 Laryngeal hemorrhagePTCTCAE E13406 Grade 1 Laryngeal hemorrhage Grade 1 Laryngeal inflammation NCIMild sore throat; raspy voice Grade 1 Laryngeal inflammationPTCTCAE E13412 Grade 1 Laryngeal inflammation Grade 1 Laryngeal mucositis NCIEndoscopic findings only; mild discomfort with normal intake Grade 1 Laryngeal mucositisPTCTCAE E13416 Grade 1 Laryngeal mucositis Grade 1 Laryngeal obstruction NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Laryngeal obstructionPTCTCAE E13422 Grade 1 Laryngeal obstruction Grade 1 Laryngeal stenosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Laryngeal stenosisPTCTCAE E13428 Grade 1 Laryngeal stenosis Grade 1 Laryngopharyngeal dysesthesia NCIMild symptoms; no anxiety; intervention not indicated Grade 1 Laryngopharyngeal dysesthesiaPTCTCAE E13434 Grade 1 Laryngopharyngeal dysesthesia Grade 1 Lethargy NCIMild symptoms; reduced alertness and awareness Grade 1 LethargyPTCTCAE E12710 Grade 1 Lethargy Grade 1 Leukoencephalopathy NCIAsymptomatic; small focal T2/FLAIR hyperintensities; involving periventricular white matter or <1/3 of susceptible areas of cerebrum +/- mild increase in subarachnoid space (SAS) and/or mild ventriculomegaly Grade 1 LeukoencephalopathyPTCTCAE E12713 Grade 1 Leukoencephalopathy Grade 1 Libido decreased NCIDecrease in sexual interest not adversely affecting relationship Grade 1 Libido decreasedPTCTCAE E12930 Grade 1 Libido decreased Grade 1 Libido increased NCIMild increase in sexual interest not adversely affecting relationship Grade 1 Libido increasedPTCTCAE E12933 Grade 1 Libido increased Grade 1 Lip infection NCILocalized, local intervention indicated Grade 1 Lip infectionPTCTCAE E11441 Grade 1 Lip infection Grade 1 Lip pain NCIMild pain Grade 1 Lip painPTCTCAE E10858 Grade 1 Lip pain Grade 1 Lipase increased NCI>ULN - 1.5 x ULN Grade 1 Lipase increasedPTCTCAE E12186 Grade 1 Lipase increased Grade 1 Lipohypertrophy NCIAsymptomatic and covering <10% BSA Grade 1 LipohypertrophyPTCTCAE E13658 Grade 1 Lipohypertrophy Grade 1 Localized edema NCILocalized to dependent areas, no disability or functional impairment Grade 1 Localized edemaPTCTCAE E11149 Grade 1 Localized edema Grade 1 Lordosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 LordosisPTCTCAE E12452 Grade 1 Lordosis Grade 1 Lower gastrointestinal hemorrhage NCIMild; intervention not indicated Grade 1 Lower gastrointestinal hemorrhagePTCTCAE E10862 Grade 1 Lower gastrointestinal hemorrhage Grade 1 Lymph node pain NCIMild pain Grade 1 Lymph node painPTCTCAE E10053 Grade 1 Lymph node pain Grade 1 Lymphedema NCITrace thickening or faint discoloration Grade 1 LymphedemaPTCTCAE E13803 Grade 1 Lymphedema Grade 1 Lymphocele NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 LymphocelePTCTCAE E13807 Grade 1 Lymphocele Grade 1 Lymphocyte count decreased NCI <LLN - 800/mm3; <LLN - 0.8 x 10e9 /L Grade 1 Lymphocyte count decreasedPTCTCAE E12191 Grade 1 Lymphocyte count decreased Grade 1 Malaise NCIUneasiness or lack of well being Grade 1 MalaisePTCTCAE E11153 Grade 1 Malaise Grade 1 Mania NCIMild manic symptoms (e.g., elevated mood, rapid thoughts, rapid speech, decreased need for sleep) Grade 1 ManiaPTCTCAE E12937 Grade 1 Mania Grade 1 Mediastinal hemorrhage NCIRadiologic evidence only; minimal symptoms; intervention not indicated Grade 1 Mediastinal hemorrhagePTCTCAE E13445 Grade 1 Mediastinal hemorrhage Grade 1 Memory impairment NCIMild memory impairment Grade 1 Memory impairmentPTCTCAE E12719 Grade 1 Memory impairment Grade 1 Meningismus NCIMild symptoms Grade 1 MeningismusPTCTCAE E12723 Grade 1 Meningismus Grade 1 Menopause NCIMenopause occurring at age 46 - 53 years of age Grade 1 MenopausePTCTCAE E13751 Grade 1 Menopause Grade 1 Menorrhagia NCIMild; iron supplements indicated Grade 1 MenorrhagiaPTCTCAE E13133 Grade 1 Menorrhagia Grade 1 Metabolism and nutrition disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Metabolism and nutrition disorders - Other, specifyPTCTCAE E12356 Grade 1 Metabolism and nutrition disorders - Other, specify Grade 1 Middle ear inflammation NCISerous otitis Grade 1 Middle ear inflammationPTCTCAE E10282 Grade 1 Middle ear inflammation Grade 1 Mitral valve disease NCIAsymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging Grade 1 Mitral valve diseasePTCTCAE E10135 Grade 1 Mitral valve disease Grade 1 Mobitz type I NCIAsymptomatic, intervention not indicated Grade 1 Mobitz type IPTCTCAE E10147 Grade 1 Mobitz type I Grade 1 Mobitz (type) II atrioventricular block NCIAsymptomatic, intervention not indicated Grade 1 Mobitz (type) II atrioventricular blockPTCTCAE E10141 Grade 1 Mobitz (type) II atrioventricular block Grade 1 Movements involuntary NCIMild symptoms Grade 1 Movements involuntaryPTCTCAE E12729 Grade 1 Movements involuntary Grade 1 Mucosal infection NCILocalized, local intervention indicated Grade 1 Mucosal infectionPTCTCAE E11463 Grade 1 Mucosal infection Grade 1 Mucositis oral NCIAsymptomatic or mild symptoms; intervention not indicated Grade 1 Mucositis oralPTCTCAE E10873 Grade 1 Mucositis oral Grade 1 Muscle weakness left-sided NCISymptomatic; perceived by patient but not evident on physical exam Grade 1 Muscle weakness left-sidedPTCTCAE E12456 Grade 1 Muscle weakness left-sided Grade 1 Muscle weakness lower limb NCISymptomatic; perceived by patient but not evident on physical exam Grade 1 Muscle weakness lower limbPTCTCAE E12460 Grade 1 Muscle weakness lower limb Grade 1 Muscle weakness right-sided NCISymptomatic; perceived by patient but not evident on physical exam Grade 1 Muscle weakness right-sidedPTCTCAE E12464 Grade 1 Muscle weakness right-sided Grade 1 Muscle weakness trunk NCISymptomatic; perceived by patient but not evident on physical exam Grade 1 Muscle weakness trunkPTCTCAE E12468 Grade 1 Muscle weakness trunk Grade 1 Muscle weakness upper limb NCISymptomatic; perceived by patient but not evident on physical exam Grade 1 Muscle weakness upper limbPTCTCAE E12472 Grade 1 Muscle weakness upper limb Grade 1 Musculoskeletal and connective tissue disorder - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Musculoskeletal and connective tissue disorder - Other, specifyPTCTCAE E12476 Grade 1 Musculoskeletal and connective tissue disorder - Other, specify Grade 1 Musculoskeletal deformity NCICosmetically and functionally insignificant hypoplasia Grade 1 Musculoskeletal deformityPTCTCAE E12482 Grade 1 Musculoskeletal deformity Grade 1 Myalgia NCIMild pain Grade 1 MyalgiaPTCTCAE E12486 Grade 1 Myalgia Grade 1 Myelitis NCIAsymptomatic; mild signs (e.g., Babinski's reflex or Lhermitte's sign) Grade 1 MyelitisPTCTCAE E12733 Grade 1 Myelitis Grade 1 Myocarditis NCIAsymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities Grade 1 MyocarditisPTCTCAE E10158 Grade 1 Myocarditis Grade 1 Myositis NCIMild pain Grade 1 MyositisPTCTCAE E12490 Grade 1 Myositis Grade 1 Nail discoloration NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Nail discolorationPTCTCAE E13662 Grade 1 Nail discoloration Grade 1 Nail infection NCILocalized, local intervention indicated Grade 1 Nail infectionPTCTCAE E11469 Grade 1 Nail infection Grade 1 Nail loss NCIAsymptomatic separation of the nail bed from the nail plate or nail loss Grade 1 Nail lossPTCTCAE E13664 Grade 1 Nail loss Grade 1 Nail ridging NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Nail ridgingPTCTCAE E13667 Grade 1 Nail ridging Grade 1 Nasal congestion NCIMild symptoms; intervention not indicated Grade 1 Nasal congestionPTCTCAE E13451 Grade 1 Nasal congestion Grade 1 Nausea NCILoss of appetite without alteration in eating habits Grade 1 NauseaPTCTCAE E10879 Grade 1 Nausea Grade 1 Neck edema NCIAsymptomatic localized neck edema Grade 1 Neck edemaPTCTCAE E11160 Grade 1 Neck edema Grade 1 Neck pain NCIMild pain Grade 1 Neck painPTCTCAE E12494 Grade 1 Neck pain Grade 1 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specifyPTCTCAE E12556 Grade 1 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify Grade 1 Nervous system disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Nervous system disorders - Other, specifyPTCTCAE E12739 Grade 1 Nervous system disorders - Other, specify Grade 1 Neuralgia NCIMild pain Grade 1 NeuralgiaPTCTCAE E12745 Grade 1 Neuralgia Grade 1 Neutrophil count decreased NCI<LLN - 1500/mm3; <LLN - 1.5 x 10e9 /L Grade 1 Neutrophil count decreasedPTCTCAE E12199 Grade 1 Neutrophil count decreased Grade 1 Night blindness NCISymptomatic but not limiting ADL Grade 1 Night blindnessPTCTCAE E10402 Grade 1 Night blindness Grade 1 Nipple deformity NCIAsymptomatic; asymmetry with slight retraction and/or thickening of the nipple areolar complex Grade 1 Nipple deformityPTCTCAE E13139 Grade 1 Nipple deformity Grade 1 Non-cardiac chest pain NCIMild pain Grade 1 Non-cardiac chest painPTCTCAE E11164 Grade 1 Non-cardiac chest pain Grade 1 Obstruction gastric NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Obstruction gastricPTCTCAE E10883 Grade 1 Obstruction gastric Grade 1 Oculomotor nerve disorder NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Oculomotor nerve disorderPTCTCAE E12752 Grade 1 Oculomotor nerve disorder Grade 1 Oligospermia NCISperm concentration >48 million/mL or motility >68% Grade 1 OligospermiaPTCTCAE E13142 Grade 1 Oligospermia Grade 1 Optic nerve disorder NCIAsymptomatic; clinical or diagnostic observations only Grade 1 Optic nerve disorderPTCTCAE E10407 Grade 1 Optic nerve disorder Grade 1 Oral cavity fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Oral cavity fistulaPTCTCAE E10889 Grade 1 Oral cavity fistula Grade 1 Oral dysesthesia NCIMild discomfort; not interfering with oral intake Grade 1 Oral dysesthesiaPTCTCAE E10895 Grade 1 Oral dysesthesia Grade 1 Oral hemorrhage NCIMild; intervention not indicated Grade 1 Oral hemorrhagePTCTCAE E10899 Grade 1 Oral hemorrhage Grade 1 Oral pain NCIMild pain Grade 1 Oral painPTCTCAE E10905 Grade 1 Oral pain Grade 1 Osteonecrosis of jaw NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Osteonecrosis of jawPTCTCAE E12503 Grade 1 Osteonecrosis of jaw Grade 1 Osteoporosis NCIRadiologic evidence of osteoporosis or Bone Mineral Density (BMD) t-score -1 to -2.5 (osteopenia); no loss of height or intervention indicated Grade 1 OsteoporosisPTCTCAE E12509 Grade 1 Osteoporosis Grade 1 Ovarian hemorrhage NCIMinimal bleeding identified on imaging study or laproscopy; intervention not indicated Grade 1 Ovarian hemorrhagePTCTCAE E13146 Grade 1 Ovarian hemorrhage Grade 1 Ovarian rupture NCIAsymptomatic clinical or diagnostic observations only; intervention not indicated Grade 1 Ovarian rupturePTCTCAE E13152 Grade 1 Ovarian rupture Grade 1 Ovulation pain NCIMild pain Grade 1 Ovulation painPTCTCAE E13158 Grade 1 Ovulation pain Grade 1 Pain NCIMild pain Grade 1 PainPTCTCAE E11168 Grade 1 Pain Grade 1 Pain in extremity NCIMild pain Grade 1 Pain in extremityPTCTCAE E12513 Grade 1 Pain in extremity Grade 1 Pain of skin NCIMild pain Grade 1 Pain of skinPTCTCAE E13669 Grade 1 Pain of skin Grade 1 Palmar-plantar erythrodysesthesia syndrome NCIMinimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain Grade 1 Palmar-plantar erythrodysesthesia syndromePTCTCAE E13673 Grade 1 Palmar-plantar erythrodysesthesia syndrome Grade 1 Palpitations NCIMild symptoms; intervention not indicated Grade 1 PalpitationsPTCTCAE E10164 Grade 1 Palpitations Grade 1 Pancreatic anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Pancreatic anastomotic leakPTCTCAE E11892 Grade 1 Pancreatic anastomotic leak Grade 1 Pancreatic duct stenosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Pancreatic duct stenosisPTCTCAE E10909 Grade 1 Pancreatic duct stenosis Grade 1 Pancreatic enzymes decreased NCI<LLN and asymptomatic Grade 1 Pancreatic enzymes decreasedPTCTCAE E12204 Grade 1 Pancreatic enzymes decreased Grade 1 Pancreatic fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Pancreatic fistulaPTCTCAE E10915 Grade 1 Pancreatic fistula Grade 1 Pancreatic hemorrhage NCIMild; intervention not indicated Grade 1 Pancreatic hemorrhagePTCTCAE E10921 Grade 1 Pancreatic hemorrhage Grade 1 Papilledema NCIAsymptomatic; no visual field defects Grade 1 PapilledemaPTCTCAE E10412 Grade 1 Papilledema Grade 1 Papulopustular rash NCIPapules and/or pustules covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness Grade 1 Papulopustular rashPTCTCAE E11492 Grade 1 Papulopustular rash Grade 1 Paresthesia NCIMild symptoms Grade 1 ParesthesiaPTCTCAE E12759 Grade 1 Paresthesia Grade 1 Paronychia NCINail fold edema or erythema; disruption of the cuticle Grade 1 ParonychiaPTCTCAE E11498 Grade 1 Paronychia Grade 1 Paroxysmal atrial tachycardia NCIAsymptomatic, intervention not indicated Grade 1 Paroxysmal atrial tachycardiaPTCTCAE E10167 Grade 1 Paroxysmal atrial tachycardia Grade 1 Pelvic floor muscle weakness NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Pelvic floor muscle weaknessPTCTCAE E13162 Grade 1 Pelvic floor muscle weakness Grade 1 Pelvic pain NCIMild pain Grade 1 Pelvic painPTCTCAE E13168 Grade 1 Pelvic pain Grade 1 Penile pain NCIMild pain Grade 1 Penile painPTCTCAE E13172 Grade 1 Penile pain Grade 1 Pericarditis NCIAsymptomatic, ECG or physical findings (e.g., rub) consistent with pericarditis Grade 1 PericarditisPTCTCAE E10181 Grade 1 Pericarditis Grade 1 Perineal pain NCIMild pain Grade 1 Perineal painPTCTCAE E13176 Grade 1 Perineal pain Grade 1 Periodontal disease NCIGingival recession or gingivitis; limited bleeding on probing; mild local bone loss Grade 1 Periodontal diseasePTCTCAE E10936 Grade 1 Periodontal disease Grade 1 Periorbital edema NCISoft or non-pitting Grade 1 Periorbital edemaPTCTCAE E13677 Grade 1 Periorbital edema Grade 1 Peripheral motor neuropathy NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Peripheral motor neuropathyPTCTCAE E12763 Grade 1 Peripheral motor neuropathy Grade 1 Peripheral sensory neuropathy NCIAsymptomatic; loss of deep tendon reflexes or paresthesia Grade 1 Peripheral sensory neuropathyPTCTCAE E12769 Grade 1 Peripheral sensory neuropathy Grade 1 Personality change NCIMild personality change Grade 1 Personality changePTCTCAE E12943 Grade 1 Personality change Grade 1 Phantom pain NCIMild pain Grade 1 Phantom painPTCTCAE E12775 Grade 1 Phantom pain Grade 1 Pharyngeal anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Pharyngeal anastomotic leakPTCTCAE E11898 Grade 1 Pharyngeal anastomotic leak Grade 1 Pharyngeal fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Pharyngeal fistulaPTCTCAE E13455 Grade 1 Pharyngeal fistula Grade 1 Pharyngeal hemorrhage NCIMild symptoms; intervention not indicated Grade 1 Pharyngeal hemorrhagePTCTCAE E13461 Grade 1 Pharyngeal hemorrhage Grade 1 Pharyngeal mucositis NCIEndoscopic findings only; minimal symptoms with normal oral intake; mild pain but analgesics not indicated Grade 1 Pharyngeal mucositisPTCTCAE E13467 Grade 1 Pharyngeal mucositis Grade 1 Pharyngeal stenosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Pharyngeal stenosisPTCTCAE E13477 Grade 1 Pharyngeal stenosis Grade 1 Pharyngolaryngeal pain NCIMild pain Grade 1 Pharyngolaryngeal painPTCTCAE E13483 Grade 1 Pharyngolaryngeal pain Grade 1 Photophobia NCISymptomatic but not limiting ADL Grade 1 PhotophobiaPTCTCAE E10417 Grade 1 Photophobia Grade 1 Photosensitivity NCIPainless erythema and erythema covering <10% BSA Grade 1 PhotosensitivityPTCTCAE E13681 Grade 1 Photosensitivity Grade 1 Platelet count decreased NCI<LLN - 75,000/mm3; <LLN - 75.0 x 10e9 /L Grade 1 Platelet count decreasedPTCTCAE E12208 Grade 1 Platelet count decreased Grade 1 Pleural effusion NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Pleural effusionPTCTCAE E13487 Grade 1 Pleural effusion Grade 1 Pleural hemorrhage NCIAsymptomatic; mild hemorrhage confirmed by thoracentesis Grade 1 Pleural hemorrhagePTCTCAE E13493 Grade 1 Pleural hemorrhage Grade 1 Pleuritic pain NCIMild pain Grade 1 Pleuritic painPTCTCAE E13499 Grade 1 Pleuritic pain Grade 1 Pneumonitis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 PneumonitisPTCTCAE E13503 Grade 1 Pneumonitis Grade 1 Pneumothorax NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 PneumothoraxPTCTCAE E13509 Grade 1 Pneumothorax Grade 1 Postnasal drip NCIMild symptoms; intervention not indicated Grade 1 Postnasal dripPTCTCAE E13515 Grade 1 Postnasal drip Grade 1 Postoperative hemorrhage NCIMinimal bleeding identified on clinical exam; intervention not indicated Grade 1 Postoperative hemorrhagePTCTCAE E11904 Grade 1 Postoperative hemorrhage Grade 1 Precocious puberty NCIPhysical signs of puberty with no biochemical markers for females <8 years and males <9 years Grade 1 Precocious pubertyPTCTCAE E10341 Grade 1 Precocious puberty Grade 1 Pregnancy, puerperium and perinatal conditions - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Pregnancy, puerperium and perinatal conditions - Other, specifyPTCTCAE E12862 Grade 1 Pregnancy, puerperium and perinatal conditions - Other, specify Grade 1 Premature delivery NCIDelivery of a liveborn infant at >34 to 37 weeks gestation Grade 1 Premature deliveryPTCTCAE E12868 Grade 1 Premature delivery Grade 1 Proctitis NCIRectal discomfort, intervention not indicated Grade 1 ProctitisPTCTCAE E10944 Grade 1 Proctitis Grade 1 Productive cough NCIOccasional/minimal production of sputum with cough Grade 1 Productive coughPTCTCAE E13518 Grade 1 Productive cough Grade 1 Prolapse of intestinal stoma NCIAsymptomatic; reducible Grade 1 Prolapse of intestinal stomaPTCTCAE E11915 Grade 1 Prolapse of intestinal stoma Grade 1 Prolapse of urostomy NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Prolapse of urostomyPTCTCAE E11921 Grade 1 Prolapse of urostomy Grade 1 Prostatic hemorrhage NCIMinimal bleeding identified on imaging study; intervention not indicated Grade 1 Prostatic hemorrhagePTCTCAE E13182 Grade 1 Prostatic hemorrhage Grade 1 Prostatic obstruction NCIDiagnostic observations only; intervention not indicated Grade 1 Prostatic obstructionPTCTCAE E13188 Grade 1 Prostatic obstruction Grade 1 Prostatic pain NCIMild pain Grade 1 Prostatic painPTCTCAE E13192 Grade 1 Prostatic pain Grade 1 Proteinuria NCI1+ proteinuria; urinary protein <1.0 g/24 hrs Grade 1 ProteinuriaPTCTCAE E13009 Grade 1 Proteinuria Grade 1 Pruritus NCIMild or localized; topical intervention indicated Grade 1 PruritusPTCTCAE E13687 Grade 1 Pruritus Grade 1 Psychiatric disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Psychiatric disorders - Other, specifyPTCTCAE E12949 Grade 1 Psychiatric disorders - Other, specify Grade 1 Psychosis NCIMild psychotic symptoms Grade 1 PsychosisPTCTCAE E12955 Grade 1 Psychosis Grade 1 Pulmonary edema NCIRadiologic findings only; minimal dyspnea on exertion Grade 1 Pulmonary edemaPTCTCAE E13522 Grade 1 Pulmonary edema Grade 1 Pulmonary fibrosis NCIMild hypoxemia; radiologic pulmonary fibrosis <25% of lung volume Grade 1 Pulmonary fibrosisPTCTCAE E13528 Grade 1 Pulmonary fibrosis Grade 1 Pulmonary fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Pulmonary fistulaPTCTCAE E13534 Grade 1 Pulmonary fistula Grade 1 Pulmonary hypertension NCIMinimal dyspnea; findings on physical exam or other evaluation Grade 1 Pulmonary hypertensionPTCTCAE E13540 Grade 1 Pulmonary hypertension Grade 1 Pulmonary valve disease NCIAsymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging Grade 1 Pulmonary valve diseasePTCTCAE E10187 Grade 1 Pulmonary valve disease Grade 1 Purpura NCICombined area of lesions covering <10% BSA Grade 1 PurpuraPTCTCAE E13691 Grade 1 Purpura Grade 1 Pyramidal tract syndrome NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Pyramidal tract syndromePTCTCAE E12781 Grade 1 Pyramidal tract syndrome Grade 1 Radiation recall reaction (dermatologic) NCIFaint erythema or dry desquamation Grade 1 Radiation recall reaction (dermatologic)PTCTCAE E11927 Grade 1 Radiation recall reaction (dermatologic) Grade 1 Radiculitis NCIMild symptoms Grade 1 RadiculitisPTCTCAE E12787 Grade 1 Radiculitis Grade 1 Rash acneiform NCIPapules and/or pustules covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness Grade 1 Rash acneiformPTCTCAE E13695 Grade 1 Rash acneiform Grade 1 Rash maculo-papular NCIMacules/papules covering <10% BSA with or without symptoms (e.g., pruritus, burning, tightness) Grade 1 Rash maculo-papularPTCTCAE E13701 Grade 1 Rash maculo-papular Grade 1 Rectal anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Rectal anastomotic leakPTCTCAE E11933 Grade 1 Rectal anastomotic leak Grade 1 Rectal fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Rectal fistulaPTCTCAE E10950 Grade 1 Rectal fistula Grade 1 Rectal hemorrhage NCIMild; intervention not indicated Grade 1 Rectal hemorrhagePTCTCAE E10956 Grade 1 Rectal hemorrhage Grade 1 Rectal mucositis NCIAsymptomatic or mild symptoms; intervention not indicated Grade 1 Rectal mucositisPTCTCAE E10962 Grade 1 Rectal mucositis Grade 1 Rectal obstruction NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Rectal obstructionPTCTCAE E10972 Grade 1 Rectal obstruction Grade 1 Rectal pain NCIMild pain Grade 1 Rectal painPTCTCAE E10978 Grade 1 Rectal pain Grade 1 Rectal stenosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Rectal stenosisPTCTCAE E10987 Grade 1 Rectal stenosis Grade 1 Rectal ulcer NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Rectal ulcerPTCTCAE E10993 Grade 1 Rectal ulcer Grade 1 Recurrent laryngeal nerve palsy NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Recurrent laryngeal nerve palsyPTCTCAE E12793 Grade 1 Recurrent laryngeal nerve palsy Grade 1 Renal and urinary disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Renal and urinary disorders - Other, specifyPTCTCAE E13013 Grade 1 Renal and urinary disorders - Other, specify Grade 1 Renal calculi NCIAsymptomatic or mild symptoms; occasional use of nonprescription analgesics indicated Grade 1 Renal calculiPTCTCAE E13019 Grade 1 Renal calculi Grade 1 Renal colic NCIMild pain not interfering with activity; nonprescription medication indicated Grade 1 Renal colicPTCTCAE E13025 Grade 1 Renal colic Grade 1 Renal hemorrhage NCIMild symptoms; intervention not indicated Grade 1 Renal hemorrhagePTCTCAE E13029 Grade 1 Renal hemorrhage Grade 1 Reproductive system and breast disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Reproductive system and breast disorders - Other, specifyPTCTCAE E13196 Grade 1 Reproductive system and breast disorders - Other, specify Grade 1 Respiratory, thoracic and mediastinal disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Respiratory, thoracic and mediastinal disorders - Other, specifyPTCTCAE E13549 Grade 1 Respiratory, thoracic and mediastinal disorders - Other, specify Grade 1 Restlessness NCIMild symptoms; intervention not indicated Grade 1 RestlessnessPTCTCAE E12961 Grade 1 Restlessness Grade 1 Retinal detachment NCIAsymptomatic Grade 1 Retinal detachmentPTCTCAE E10421 Grade 1 Retinal detachment Grade 1 Retinoic acid syndrome NCIFluid retention; <3 kg of weight gain; intervention with fluid restriction and/or diuretics indicated Grade 1 Retinoic acid syndromePTCTCAE E13555 Grade 1 Retinoic acid syndrome Grade 1 Retinopathy NCIAsymptomatic; clinical or diagnostic observations only Grade 1 RetinopathyPTCTCAE E10433 Grade 1 Retinopathy Grade 1 Reversible posterior leukoencephalopathy syndrome NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Reversible posterior leukoencephalopathy syndromePTCTCAE E12799 Grade 1 Reversible posterior leukoencephalopathy syndrome Grade 1 Right ventricular dysfunction NCIAsymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities Grade 1 Right ventricular dysfunctionPTCTCAE E10197 Grade 1 Right ventricular dysfunction Grade 1 Salivary duct inflammation NCISlightly thickened saliva; slightly altered taste (e.g., metallic) Grade 1 Salivary duct inflammationPTCTCAE E11004 Grade 1 Salivary duct inflammation Grade 1 Salivary gland fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Salivary gland fistulaPTCTCAE E11010 Grade 1 Salivary gland fistula Grade 1 Scalp pain NCIMild pain Grade 1 Scalp painPTCTCAE E13705 Grade 1 Scalp pain Grade 1 Scleral disorder NCIAsymptomatic; clinical or diagnostic observations only Grade 1 Scleral disorderPTCTCAE E10438 Grade 1 Scleral disorder Grade 1 Scoliosis NCI<20 degrees; clinically undetectable Grade 1 ScoliosisPTCTCAE E12522 Grade 1 Scoliosis Grade 1 Scrotal pain NCIMild pain Grade 1 Scrotal painPTCTCAE E13202 Grade 1 Scrotal pain Grade 1 Seizure NCIBrief partial seizure; no loss of consciousness Grade 1 SeizurePTCTCAE E12805 Grade 1 Seizure Grade 1 Seroma NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 SeromaPTCTCAE E11939 Grade 1 Seroma Grade 1 Serum amylase increased NCI>ULN - 1.5 x ULN Grade 1 Serum amylase increasedPTCTCAE E12213 Grade 1 Serum amylase increased Grade 1 Serum sickness NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Serum sicknessPTCTCAE E11277 Grade 1 Serum sickness Grade 1 Sick sinus syndrome NCIAsymptomatic, intervention not indicated Grade 1 Sick sinus syndromePTCTCAE E10203 Grade 1 Sick sinus syndrome Grade 1 Sinus bradycardia NCIAsymptomatic, intervention not indicated Grade 1 Sinus bradycardiaPTCTCAE E10209 Grade 1 Sinus bradycardia Grade 1 Sinus disorder NCIAsymptomatic mucosal crusting; blood-tinged secretions Grade 1 Sinus disorderPTCTCAE E13561 Grade 1 Sinus disorder Grade 1 Sinus pain NCIMild pain Grade 1 Sinus painPTCTCAE E12811 Grade 1 Sinus pain Grade 1 Sinus tachycardia NCIAsymptomatic, intervention not indicated Grade 1 Sinus tachycardiaPTCTCAE E10215 Grade 1 Sinus tachycardia Grade 1 Skin and subcutaneous tissue disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Skin and subcutaneous tissue disorders - Other, specifyPTCTCAE E13709 Grade 1 Skin and subcutaneous tissue disorders - Other, specify Grade 1 Skin atrophy NCICovering <10% BSA; associated with telangiectasias or changes in skin color Grade 1 Skin atrophyPTCTCAE E13715 Grade 1 Skin atrophy Grade 1 Skin hyperpigmentation NCIHyperpigmentation covering <10% BSA; no psychosocial impact Grade 1 Skin hyperpigmentationPTCTCAE E13719 Grade 1 Skin hyperpigmentation Grade 1 Skin hypopigmentation NCIHypopigmentation or depigmentation covering <10% BSA; no psychosocial impact Grade 1 Skin hypopigmentationPTCTCAE E13722 Grade 1 Skin hypopigmentation Grade 1 Skin induration NCIMild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up) Grade 1 Skin indurationPTCTCAE E13725 Grade 1 Skin induration Grade 1 Skin infection NCILocalized, local intervention indicated Grade 1 Skin infectionPTCTCAE E11569 Grade 1 Skin infection Grade 1 Skin ulceration NCICombined area of ulcers <1 cm; nonblanchable erythema of intact skin with associated warmth or edema Grade 1 Skin ulcerationPTCTCAE E13731 Grade 1 Skin ulceration Grade 1 Sleep apnea NCISnoring and nocturnal sleep arousal without apneic periods Grade 1 Sleep apneaPTCTCAE E13567 Grade 1 Sleep apnea Grade 1 Small intestinal anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Small intestinal anastomotic leakPTCTCAE E11943 Grade 1 Small intestinal anastomotic leak Grade 1 Small intestinal mucositis NCIAsymptomatic or mild symptoms; intervention not indicated Grade 1 Small intestinal mucositisPTCTCAE E11016 Grade 1 Small intestinal mucositis Grade 1 Small intestinal obstruction NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Small intestinal obstructionPTCTCAE E11022 Grade 1 Small intestinal obstruction Grade 1 Small intestinal stenosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Small intestinal stenosisPTCTCAE E11033 Grade 1 Small intestinal stenosis Grade 1 Small intestine ulcer NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Small intestine ulcerPTCTCAE E11039 Grade 1 Small intestine ulcer Grade 1 Sneezing NCIMild symptoms; intervention not indicated Grade 1 SneezingPTCTCAE E13573 Grade 1 Sneezing Grade 1 Social circumstances - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Social circumstances - Other, specifyPTCTCAE E13755 Grade 1 Social circumstances - Other, specify Grade 1 Somnolence NCIMild but more than usual drowsiness or sleepiness Grade 1 SomnolencePTCTCAE E12815 Grade 1 Somnolence Grade 1 Sore throat NCIMild pain Grade 1 Sore throatPTCTCAE E13576 Grade 1 Sore throat Grade 1 Spasticity NCIMild or slight increase in muscle tone Grade 1 SpasticityPTCTCAE E12821 Grade 1 Spasticity Grade 1 Spermatic cord anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Spermatic cord anastomotic leakPTCTCAE E11949 Grade 1 Spermatic cord anastomotic leak Grade 1 Spermatic cord hemorrhage NCIMinimal bleeding identified on imaging study; intervention not indicated Grade 1 Spermatic cord hemorrhagePTCTCAE E13206 Grade 1 Spermatic cord hemorrhage Grade 1 Spermatic cord obstruction NCIDiagnostic observations only; intervention not indicated Grade 1 Spermatic cord obstructionPTCTCAE E13212 Grade 1 Spermatic cord obstruction Grade 1 Spinal fracture NCIMild back pain; nonprescription analgesics indicated Grade 1 Spinal fracturePTCTCAE E11955 Grade 1 Spinal fracture Grade 1 Spleen disorder NCIIncidental findings (e.g., Howell-Jolly bodies); mild degree of thrombocytosis and leukocytosis Grade 1 Spleen disorderPTCTCAE E10057 Grade 1 Spleen disorder Grade 1 Stoma site infection NCILocalized, local intervention indicated Grade 1 Stoma site infectionPTCTCAE E11589 Grade 1 Stoma site infection Grade 1 Stomach pain NCIMild pain Grade 1 Stomach painPTCTCAE E11045 Grade 1 Stomach pain Grade 1 Stomal ulcer NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Stomal ulcerPTCTCAE E11966 Grade 1 Stomal ulcer Grade 1 Stroke NCIAsymptomatic or mild neurologic deficit; radiographic findings only Grade 1 StrokePTCTCAE E12827 Grade 1 Stroke Grade 1 Suicidal ideation NCIIncreased thoughts of death but no wish to kill oneself Grade 1 Suicidal ideationPTCTCAE E12965 Grade 1 Suicidal ideation Grade 1 Superficial soft tissue fibrosis NCIMild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up) Grade 1 Superficial soft tissue fibrosisPTCTCAE E12536 Grade 1 Superficial soft tissue fibrosis Grade 1 Superior vena cava syndrome NCIAsymptomatic; incidental finding of SVC thrombosis Grade 1 Superior vena cava syndromePTCTCAE E13820 Grade 1 Superior vena cava syndrome Grade 1 Supraventricular tachycardia NCIAsymptomatic, intervention not indicated Grade 1 Supraventricular tachycardiaPTCTCAE E10219 Grade 1 Supraventricular tachycardia Grade 1 Surgical and medical procedures - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Surgical and medical procedures - Other, specifyPTCTCAE E13761 Grade 1 Surgical and medical procedures - Other, specify Grade 1 Telangiectasia NCITelangiectasias covering <10% BSA Grade 1 TelangiectasiaPTCTCAE E13741 Grade 1 Telangiectasia Grade 1 Testicular disorder NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Testicular disorderPTCTCAE E13216 Grade 1 Testicular disorder Grade 1 Testicular hemorrhage NCIMinimal bleeding identified on imaging study; intervention not indicated Grade 1 Testicular hemorrhagePTCTCAE E13222 Grade 1 Testicular hemorrhage Grade 1 Testicular pain NCIMild pain Grade 1 Testicular painPTCTCAE E13228 Grade 1 Testicular pain Grade 1 Thromboembolic event NCIVenous thrombosis (e.g., superficial thrombosis) Grade 1 Thromboembolic eventPTCTCAE E13826 Grade 1 Thromboembolic event Grade 1 Thrombotic thrombocytopenic purpura NCIEvidence of RBC destruction (schistocytosis) without clinical consequences Grade 1 Thrombotic thrombocytopenic purpuraPTCTCAE E10062 Grade 1 Thrombotic thrombocytopenic purpura Grade 1 Tinnitus NCIMild symptoms; intervention not indicated Grade 1 TinnitusPTCTCAE E10288 Grade 1 Tinnitus Grade 1 Tooth development disorder NCIAsymptomatic; hypoplasia of tooth or enamel Grade 1 Tooth development disorderPTCTCAE E11049 Grade 1 Tooth development disorder Grade 1 Tooth discoloration NCISurface stains Grade 1 Tooth discolorationPTCTCAE E11053 Grade 1 Tooth discoloration Grade 1 Toothache NCIMild pain Grade 1 ToothachePTCTCAE E11055 Grade 1 Toothache Grade 1 Tracheal fistula NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Tracheal fistulaPTCTCAE E13584 Grade 1 Tracheal fistula Grade 1 Tracheal hemorrhage NCIMinimal bleeding identified on clinical or diagnostic exam; intervention not indicated Grade 1 Tracheal hemorrhagePTCTCAE E11970 Grade 1 Tracheal hemorrhage Grade 1 Tracheal mucositis NCIEndoscopic findings only; minimal hemoptysis, pain, or respiratory symptoms Grade 1 Tracheal mucositisPTCTCAE E13590 Grade 1 Tracheal mucositis Grade 1 Tracheal obstruction NCIPartial asymptomatic obstruction on examination (e.g., visual, radiologic or endoscopic) Grade 1 Tracheal obstructionPTCTCAE E11976 Grade 1 Tracheal obstruction Grade 1 Tracheal stenosis NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Tracheal stenosisPTCTCAE E13596 Grade 1 Tracheal stenosis Grade 1 Tracheostomy site bleeding NCIMinimal bleeding identified on clinical exam; intervention not indicated Grade 1 Tracheostomy site bleedingPTCTCAE E11982 Grade 1 Tracheostomy site bleeding Grade 1 Transient ischemic attacks NCIMild neurologic deficit with or without imaging confirmation Grade 1 Transient ischemic attacksPTCTCAE E12835 Grade 1 Transient ischemic attacks Grade 1 Tremor NCIMild symptoms Grade 1 TremorPTCTCAE E12838 Grade 1 Tremor Grade 1 Tricuspid valve disease NCIAsymptomatic valvular thickening with or without mild valvular regurgitation or stenosis Grade 1 Tricuspid valve diseasePTCTCAE E10225 Grade 1 Tricuspid valve disease Grade 1 Trigeminal nerve disorder NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Trigeminal nerve disorderPTCTCAE E12842 Grade 1 Trigeminal nerve disorder Grade 1 Trismus NCIDecreased ROM (range of motion) without impaired eating Grade 1 TrismusPTCTCAE E12542 Grade 1 Trismus Grade 1 Tumor pain NCIMild pain Grade 1 Tumor painPTCTCAE E12566 Grade 1 Tumor pain Grade 1 Unequal limb length NCIMild length discrepancy <2 cm Grade 1 Unequal limb lengthPTCTCAE E12546 Grade 1 Unequal limb length Grade 1 Upper gastrointestinal hemorrhage NCIMild; intervention not indicated Grade 1 Upper gastrointestinal hemorrhagePTCTCAE E11063 Grade 1 Upper gastrointestinal hemorrhage Grade 1 Ureteric anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Ureteric anastomotic leakPTCTCAE E11988 Grade 1 Ureteric anastomotic leak Grade 1 Urethral anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Urethral anastomotic leakPTCTCAE E11994 Grade 1 Urethral anastomotic leak Grade 1 Urinary frequency NCIPresent Grade 1 Urinary frequencyPTCTCAE E13040 Grade 1 Urinary frequency Grade 1 Urinary incontinence NCIOccasional (e.g., with coughing, sneezing, etc.), pads not indicated Grade 1 Urinary incontinencePTCTCAE E13043 Grade 1 Urinary incontinence Grade 1 Urinary retention NCIUrinary, suprapubic or intermittent catheter placement not indicated; able to void with some residual Grade 1 Urinary retentionPTCTCAE E13047 Grade 1 Urinary retention Grade 1 Urinary tract obstruction NCIAsymptomatic; clinical or diagnostic observations only Grade 1 Urinary tract obstructionPTCTCAE E13053 Grade 1 Urinary tract obstruction Grade 1 Urinary tract pain NCIMild pain Grade 1 Urinary tract painPTCTCAE E13059 Grade 1 Urinary tract pain Grade 1 Urinary urgency NCIPresent Grade 1 Urinary urgencyPTCTCAE E13063 Grade 1 Urinary urgency Grade 1 Urine discoloration NCIPresent Grade 1 Urine discolorationPTCTCAE E13066 Grade 1 Urine discoloration Grade 1 Urostomy leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Urostomy leakPTCTCAE E12000 Grade 1 Urostomy leak Grade 1 Urostomy obstruction NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Urostomy obstructionPTCTCAE E12006 Grade 1 Urostomy obstruction Grade 1 Urostomy site bleeding NCIMinimal bleeding identified on clinical exam; intervention not indicated Grade 1 Urostomy site bleedingPTCTCAE E12012 Grade 1 Urostomy site bleeding Grade 1 Urticaria NCIUrticarial lesions covering <10% BSA; topical intervention indicated Grade 1 UrticariaPTCTCAE E13747 Grade 1 Urticaria Grade 1 Uterine anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Uterine anastomotic leakPTCTCAE E12023 Grade 1 Uterine anastomotic leak Grade 1 Uterine fistula NCIAsymptomatic clinical or diagnostic observations only; intervention not indicated Grade 1 Uterine fistulaPTCTCAE E13232 Grade 1 Uterine fistula Grade 1 Uterine hemorrhage NCIMinimal bleeding identified on imaging study; intervention not indicated Grade 1 Uterine hemorrhagePTCTCAE E13238 Grade 1 Uterine hemorrhage Grade 1 Uterine obstruction NCIDiagnostic observations only; intervention not indicated Grade 1 Uterine obstructionPTCTCAE E13244 Grade 1 Uterine obstruction Grade 1 Uterine pain NCIMild pain Grade 1 Uterine painPTCTCAE E13248 Grade 1 Uterine pain Grade 1 Uterine perforation NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Uterine perforationPTCTCAE E12029 Grade 1 Uterine perforation Grade 1 Uveitis NCIAsymptomatic; clinical or diagnostic observations only Grade 1 UveitisPTCTCAE E10443 Grade 1 Uveitis Grade 1 Vaginal anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Vaginal anastomotic leakPTCTCAE E12035 Grade 1 Vaginal anastomotic leak Grade 1 Vaginal discharge NCIMild vaginal discharge (greater than baseline for patient) Grade 1 Vaginal dischargePTCTCAE E13252 Grade 1 Vaginal discharge Grade 1 Vaginal dryness NCIMild vaginal dryness not interfering with sexual function Grade 1 Vaginal drynessPTCTCAE E13255 Grade 1 Vaginal dryness Grade 1 Vaginal fistula NCIAsymptomatic clinical or diagnostic observations only; intervention not indicated Grade 1 Vaginal fistulaPTCTCAE E13259 Grade 1 Vaginal fistula Grade 1 Vaginal hemorrhage NCIMinimal bleeding identified on clinical exam or imaging study; intervention not indicated Grade 1 Vaginal hemorrhagePTCTCAE E13265 Grade 1 Vaginal hemorrhage Grade 1 Vaginal inflammation NCIMild discomfort or pain, edema, or redness Grade 1 Vaginal inflammationPTCTCAE E13271 Grade 1 Vaginal inflammation Grade 1 Vaginal obstruction NCIDiagnostic observations only; intervention not indicated Grade 1 Vaginal obstructionPTCTCAE E13277 Grade 1 Vaginal obstruction Grade 1 Vaginal pain NCIMild pain Grade 1 Vaginal painPTCTCAE E13281 Grade 1 Vaginal pain Grade 1 Vaginal perforation NCIAsymptomatic clinical or diagnostic observations only; intervention not indicated Grade 1 Vaginal perforationPTCTCAE E13285 Grade 1 Vaginal perforation Grade 1 Vaginal stricture NCIAsymptomatic; mild vaginal shortening or narrowing Grade 1 Vaginal stricturePTCTCAE E13291 Grade 1 Vaginal stricture Grade 1 Vaginismus NCIMild discomfort or pain associated with vaginal spasm/tightening; no impact upon sexual function or physical examination Grade 1 VaginismusPTCTCAE E13296 Grade 1 Vaginismus Grade 1 Vagus nerve disorder NCIAsymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 1 Vagus nerve disorderPTCTCAE E12846 Grade 1 Vagus nerve disorder Grade 1 Vas deferens anastomotic leak NCIAsymptomatic diagnostic observations only; intervention not indicated Grade 1 Vas deferens anastomotic leakPTCTCAE E12041 Grade 1 Vas deferens anastomotic leak Grade 1 Vascular disorders - Other, specify NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Grade 1 Vascular disorders - Other, specifyPTCTCAE E13832 Grade 1 Vascular disorders - Other, specify Grade 1 Vasculitis NCIAsymptomatic, intervention not indicated Grade 1 VasculitisPTCTCAE E13838 Grade 1 Vasculitis Grade 1 Venous injury NCIAsymptomatic diagnostic finding; intervention not indicated Grade 1 Venous injuryPTCTCAE E12052 Grade 1 Venous injury Grade 1 Ventricular arrhythmia NCIAsymptomatic, intervention not indicated Grade 1 Ventricular arrhythmiaPTCTCAE E10231 Grade 1 Ventricular arrhythmia Grade 1 Vertigo NCIMild symptoms Grade 1 VertigoPTCTCAE E10292 Grade 1 Vertigo Grade 1 Virilization NCIMild symptoms; intervention not indicated Grade 1 VirilizationPTCTCAE E10344 Grade 1 Virilization Grade 1 Vital capacity abnormal NCI90 - 75% of predicted value Grade 1 Vital capacity abnormalPTCTCAE E12221 Grade 1 Vital capacity abnormal Grade 1 Vitreous hemorrhage NCIAsymptomatic or mild symptoms; clinical or diagnostic observations only Grade 1 Vitreous hemorrhagePTCTCAE E10448 Grade 1 Vitreous hemorrhage Grade 1 Voice alteration NCIMild or intermittent change from normal voice Grade 1 Voice alterationPTCTCAE E13602 Grade 1 Voice alteration Grade 1 Vomiting NCI1 - 2 episodes (separated by 5 minutes) in 24 hrs Grade 1 VomitingPTCTCAE E11069 Grade 1 Vomiting Grade 1 Vulval infection NCILocalized, local intervention indicated Grade 1 Vulval infectionPTCTCAE E11630 Grade 1 Vulval infection Grade 1 Watering eyes NCIIntervention not indicated Grade 1 Watering eyesPTCTCAE E10453 Grade 1 Watering eyes Grade 1 Weight gain NCI5 - <10% from baseline Grade 1 Weight gainPTCTCAE E12225 Grade 1 Weight gain Grade 1 Weight loss NCI5 to <10% from baseline; intervention not indicated Grade 1 Weight lossPTCTCAE E12229 Grade 1 Weight loss Grade 1 Wheezing NCIDetectable airway noise with minimal symptoms Grade 1 WheezingPTCTCAE E13606 Grade 1 Wheezing Grade 1 White blood cell decreased NCI<LLN - 3000/mm3; <LLN - 3.0 x 10e9 /L Grade 1 White blood cell decreasedPTCTCAE E12233 Grade 1 White blood cell decreased Grade 1 Wolff-Parkinson-White syndrome NCIAsymptomatic, intervention not indicated Grade 1 Wolff-Parkinson-White syndromePTCTCAE E10245 Grade 1 Wolff-Parkinson-White syndrome Grade 1 Wound complication NCIIncisional separation of <=25% of wound, no deeper than superficial fascia Grade 1 Wound complicationPTCTCAE E12058 Grade 1 Wound complication Grade 1 Wound dehiscence NCIIncisional separation of <=25% of wound, no deeper than superficial fascia Grade 1 Wound dehiscencePTCTCAE E12064 Grade 1 Wound dehiscence Grade 1 Wrist fracture NCIMild; non-surgical intervention indicated Grade 1 Wrist fracturePTCTCAE E12070 Grade 1 Wrist fracture Grade 2 Abdominal distension NCISymptomatic; limiting instrumental ADL Grade 2 Abdominal distensionPTCTCAE E10458 Grade 2 Abdominal distension Grade 2 Abdominal pain NCIModerate pain; limiting instrumental ADL Grade 2 Abdominal painPTCTCAE E10462 Grade 2 Abdominal pain Grade 2 Abdominal soft tissue necrosis NCILocal wound care; medical intervention indicated (e.g., dressings or topical medications) Grade 2 Abdominal soft tissue necrosisPTCTCAE E12370 Grade 2 Abdominal soft tissue necrosis Grade 2 Abducens nerve disorder NCIModerate symptoms; limiting instrumental ADL Grade 2 Abducens nerve disorderPTCTCAE E12571 Grade 2 Abducens nerve disorder Grade 2 Accessory nerve disorder NCIModerate symptoms; limiting instrumental ADL Grade 2 Accessory nerve disorderPTCTCAE E12575 Grade 2 Accessory nerve disorder Grade 2 Acoustic nerve disorder NOS NCIModerate symptoms; limiting instrumental ADL Grade 2 Acoustic nerve disorder NOSPTCTCAE E12579 Grade 2 Acoustic nerve disorder NOS Grade 2 Activated partial thromboplastin time prolonged NCI>1.5 - 2.5 x ULN Grade 2 Activated partial thromboplastin time prolongedPTCTCAE E12075 Grade 2 Activated partial thromboplastin time prolonged Grade 2 Acute coronary syndrome NCISymptomatic, progressive angina; cardiac enzymes normal; hemodynamically stable Grade 2 Acute coronary syndromePTCTCAE E10067 Grade 2 Acute coronary syndrome Grade 2 Acute kidney injury NCICreatinine 2 - 3 x above baseline Grade 2 Acute kidney injuryPTCTCAE E12975 Grade 2 Acute kidney injury Grade 2 Adrenal insufficiency NCIModerate symptoms; medical intervention indicated Grade 2 Adrenal insufficiencyPTCTCAE E10300 Grade 2 Adrenal insufficiency Grade 2 Adverse Event NCIAn adverse event for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated, or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances). Grade 2 Adverse EventPTCTCAE Moderate Adverse EventSYCTCAE E10006 Grade 2 Adverse Event Grade 2 Agitation NCIModerate mood alteration Grade 2 AgitationPTCTCAE E12876 Grade 2 Agitation Grade 2 Akathisia NCIModerate restlessness or increased motor activity; limiting instrumental ADL Grade 2 AkathisiaPTCTCAE E12583 Grade 2 Akathisia Grade 2 Alanine aminotransferase increased NCI>3.0 - 5.0 x ULN Grade 2 Alanine aminotransferase increasedPTCTCAE E12079 Grade 2 Alanine aminotransferase increased Grade 2 Alcohol intolerance NCIPresent Grade 2 Alcohol intolerancePTCTCAE E12243 Grade 2 Alcohol intolerance Grade 2 Alkaline phosphatase increased NCI>2.5 - 5.0 x ULN Grade 2 Alkaline phosphatase increasedPTCTCAE E12084 Grade 2 Alkaline phosphatase increased Grade 2 Allergic reaction NCIIntervention or infusion interruption indicated; responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics); prophylactic medications indicated for <=24 hrs Grade 2 Allergic reactionPTCTCAE E11250 Grade 2 Allergic reaction Grade 2 Allergic rhinitis NCIModerate symptoms; medical intervention indicated Grade 2 Allergic rhinitisPTCTCAE E13305 Grade 2 Allergic rhinitis Grade 2 Alopecia NCIHair loss of >=50% normal for that individual that is readily apparent to others; a wig or hair piece is necessary if the patient desires to completely camouflage the hair loss; associated with psychosocial impact Grade 2 AlopeciaPTCTCAE E13613 Grade 2 Alopecia Grade 2 Amnesia NCIModerate; short term memory loss; limiting instrumental ADL Grade 2 AmnesiaPTCTCAE E12587 Grade 2 Amnesia Grade 2 Anal fistula NCISymptomatic; altered GI function Grade 2 Anal fistulaPTCTCAE E10466 Grade 2 Anal fistula Grade 2 Anal hemorrhage NCIModerate symptoms; medical intervention or minor cauterization indicated Grade 2 Anal hemorrhagePTCTCAE E10472 Grade 2 Anal hemorrhage Grade 2 Anal mucositis NCISymptomatic; medical intervention indicated; limiting instrumental ADL Grade 2 Anal mucositisPTCTCAE E10478 Grade 2 Anal mucositis Grade 2 Anal pain NCIModerate pain; limiting instrumental ADL Grade 2 Anal painPTCTCAE E10488 Grade 2 Anal pain Grade 2 Anal stenosis NCISymptomatic; altered GI function Grade 2 Anal stenosisPTCTCAE E10492 Grade 2 Anal stenosis Grade 2 Anal ulcer NCISymptomatic; altered GI function Grade 2 Anal ulcerPTCTCAE E10498 Grade 2 Anal ulcer Grade 2 Anemia NCIHgb <10.0 - 8.0 g/dL; <6.2 - 4.9 mmol/L; <100 - 80g/L Grade 2 AnemiaPTCTCAE E10012 Grade 2 Anemia Grade 2 Ankle fracture NCILimiting instrumental ADL; operative intervention indicated Grade 2 Ankle fracturePTCTCAE E11642 Grade 2 Ankle fracture Grade 2 Anorectal infection NCIOral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Anorectal infectionPTCTCAE E11288 Grade 2 Anorectal infection Grade 2 Anorexia NCIOral intake altered without significant weight loss or malnutrition; oral nutritional supplements indicated Grade 2 AnorexiaPTCTCAE E12254 Grade 2 Anorexia Grade 2 Anorgasmia NCIInability to achieve orgasm adversely affecting relationship Grade 2 AnorgasmiaPTCTCAE E12882 Grade 2 Anorgasmia Grade 2 Anxiety NCIModerate symptoms; limiting instrumental ADL Grade 2 AnxietyPTCTCAE E12885 Grade 2 Anxiety Grade 2 Aortic valve disease NCIAsymptomatic; moderate regurgitation or stenosis by imaging Grade 2 Aortic valve diseasePTCTCAE E10073 Grade 2 Aortic valve disease Grade 2 Appendicitis perforated NCISymptomatic; medical intervention indicated Grade 2 Appendicitis perforatedPTCTCAE E11297 Grade 2 Appendicitis perforated Grade 2 Arachnoiditis NCIModerate symptoms; limiting instrumental ADL Grade 2 ArachnoiditisPTCTCAE E12593 Grade 2 Arachnoiditis Grade 2 Arterial injury NCISymptomatic (e.g., claudication); repair or revision not indicated Grade 2 Arterial injuryPTCTCAE E11650 Grade 2 Arterial injury Grade 2 Arthralgia NCIModerate pain; limiting instrumental ADL Grade 2 ArthralgiaPTCTCAE E12376 Grade 2 Arthralgia Grade 2 Arthritis NCIModerate pain associated with signs of inflammation, erythema, or joint swelling; limiting instrumental ADL Grade 2 ArthritisPTCTCAE E12380 Grade 2 Arthritis Grade 2 Ascites NCISymptomatic; medical intervention indicated Grade 2 AscitesPTCTCAE E10504 Grade 2 Ascites Grade 2 Aspartate aminotransferase increased NCI>3.0 - 5.0 x ULN Grade 2 Aspartate aminotransferase increasedPTCTCAE E12089 Grade 2 Aspartate aminotransferase increased Grade 2 Aspiration NCIAltered eating habits; coughing or choking episodes after eating or swallowing; medical intervention indicated (e.g., suction or oxygen) Grade 2 AspirationPTCTCAE E13312 Grade 2 Aspiration Grade 2 Ataxia NCIModerate symptoms; limiting instrumental ADL Grade 2 AtaxiaPTCTCAE E12599 Grade 2 Ataxia Grade 2 Atelectasis NCISymptomatic (e.g., dyspnea, cough); medical intervention indicated (e.g., chest physiotherapy, suctioning); bronchoscopic suctioning Grade 2 AtelectasisPTCTCAE E13318 Grade 2 Atelectasis Grade 2 Atrial fibrillation NCINon-urgent medical intervention indicated Grade 2 Atrial fibrillationPTCTCAE E10083 Grade 2 Atrial fibrillation Grade 2 Atrial flutter NCINon-urgent medical intervention indicated Grade 2 Atrial flutterPTCTCAE E10089 Grade 2 Atrial flutter Grade 2 Atrioventricular block complete NCINon-urgent intervention indicated Grade 2 Atrioventricular block completePTCTCAE E10094 Grade 2 Atrioventricular block complete Grade 2 Atrioventricular block first degree NCINon-urgent intervention indicated Grade 2 Atrioventricular block first degreePTCTCAE E10100 Grade 2 Atrioventricular block first degree Grade 2 Autoimmune disorder NCIEvidence of autoimmune reaction involving a non-essential organ or function (e.g., hypothyroidism) Grade 2 Autoimmune disorderPTCTCAE E11260 Grade 2 Autoimmune disorder Grade 2 Avascular necrosis NCISymptomatic; limiting instrumental ADL Grade 2 Avascular necrosisPTCTCAE E12384 Grade 2 Avascular necrosis Grade 2 Back pain NCIModerate pain; limiting instrumental ADL Grade 2 Back painPTCTCAE E12390 Grade 2 Back pain Grade 2 Bile duct stenosis NCISymptomatic; altered GI function; IV fluids indicated <24 hrs Grade 2 Bile duct stenosisPTCTCAE E11175 Grade 2 Bile duct stenosis Grade 2 Biliary anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Biliary anastomotic leakPTCTCAE E11656 Grade 2 Biliary anastomotic leak Grade 2 Biliary fistula NCISymptomatic and intervention not indicated Grade 2 Biliary fistulaPTCTCAE E11180 Grade 2 Biliary fistula Grade 2 Bladder anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Bladder anastomotic leakPTCTCAE E11662 Grade 2 Bladder anastomotic leak Grade 2 Bladder infection NCIOral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Bladder infectionPTCTCAE E11310 Grade 2 Bladder infection Grade 2 Bladder perforation NCIExtraperitoneal perforation, indwelling catheter indicated Grade 2 Bladder perforationPTCTCAE E12980 Grade 2 Bladder perforation Grade 2 Bladder spasm NCIAntispasmodics indicated Grade 2 Bladder spasmPTCTCAE E12986 Grade 2 Bladder spasm Grade 2 Bloating NCISymptomatic, decreased oral intake; change in bowel function Grade 2 BloatingPTCTCAE E10510 Grade 2 Bloating Grade 2 Blood and lymphatic system disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Blood and lymphatic system disorders - Other, specifyPTCTCAE E10018 Grade 2 Blood and lymphatic system disorders - Other, specify Grade 2 Blood antidiuretic hormone abnormal NCISymptomatic; medical intervention indicated Grade 2 Blood antidiuretic hormone abnormalPTCTCAE E12094 Grade 2 Blood antidiuretic hormone abnormal Grade 2 Blood bilirubin increased NCI>1.5 - 3.0 x ULN Grade 2 Blood bilirubin increasedPTCTCAE E12098 Grade 2 Blood bilirubin increased Grade 2 Blood corticotrophin decreased NCISymptomatic; medical intervention indicated Grade 2 Blood corticotrophin decreasedPTCTCAE E12103 Grade 2 Blood corticotrophin decreased Grade 2 Blood gonadotrophin abnormal NCISymptomatic; medical intervention indicated; limiting instrumental ADL Grade 2 Blood gonadotrophin abnormalPTCTCAE E12107 Grade 2 Blood gonadotrophin abnormal Grade 2 Blood prolactin abnormal NCIModerate symptoms; limiting instrumental ADL Grade 2 Blood prolactin abnormalPTCTCAE E12111 Grade 2 Blood prolactin abnormal Grade 2 Blurred vision NCISymptomatic; limiting instrumental ADL Grade 2 Blurred visionPTCTCAE E10348 Grade 2 Blurred vision Grade 2 Body odor NCIPronounced odor; psychosocial impact; patient seeks medical intervention Grade 2 Body odorPTCTCAE E13616 Grade 2 Body odor Grade 2 Bone marrow hypocellular NCIModerately hypocellular or >25 - <50% reduction from normal cellularity for age Grade 2 Bone marrow hypocellularPTCTCAE E10024 Grade 2 Bone marrow hypocellular Grade 2 Bone pain NCIModerate pain; limiting instrumental ADL Grade 2 Bone painPTCTCAE E12394 Grade 2 Bone pain Grade 2 Brachial plexopathy NCIModerate symptoms; limiting instrumental ADL Grade 2 Brachial plexopathyPTCTCAE E12603 Grade 2 Brachial plexopathy Grade 2 Breast atrophy NCIModerate asymmetry; moderate atrophy Grade 2 Breast atrophyPTCTCAE E13071 Grade 2 Breast atrophy Grade 2 Breast infection NCILocal infection with moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Breast infectionPTCTCAE E11319 Grade 2 Breast infection Grade 2 Breast pain NCIModerate pain; limiting instrumental ADL Grade 2 Breast painPTCTCAE E13075 Grade 2 Breast pain Grade 2 Bronchial fistula NCISymptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL Grade 2 Bronchial fistulaPTCTCAE E13324 Grade 2 Bronchial fistula Grade 2 Bronchial infection NCIModerate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Bronchial infectionPTCTCAE E11324 Grade 2 Bronchial infection Grade 2 Bronchial obstruction NCISymptomatic (e.g., mild wheezing); endoscopic evaluation indicated; radiographic evidence of atelectasis/lobar collapse; medical management indicated (e.g., steroids, bronchodilators) Grade 2 Bronchial obstructionPTCTCAE E13330 Grade 2 Bronchial obstruction Grade 2 Bronchial stricture NCISymptomatic (e.g., rhonchi or wheezing) but without respiratory distress; medical intervention indicated (e.g., steroids, bronchodilators) Grade 2 Bronchial stricturePTCTCAE E13336 Grade 2 Bronchial stricture Grade 2 Bronchopleural fistula NCISymptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL Grade 2 Bronchopleural fistulaPTCTCAE E13342 Grade 2 Bronchopleural fistula Grade 2 Bronchopulmonary hemorrhage NCIModerate symptoms; medical intervention indicated Grade 2 Bronchopulmonary hemorrhagePTCTCAE E13348 Grade 2 Bronchopulmonary hemorrhage Grade 2 Bronchospasm NCISymptomatic; medical intervention indicated; limiting instrumental ADL Grade 2 BronchospasmPTCTCAE E13354 Grade 2 Bronchospasm Grade 2 Bruising NCIGeneralized Grade 2 BruisingPTCTCAE E11668 Grade 2 Bruising Grade 2 Bullous dermatitis NCIBlisters covering 10 - 30% BSA; painful blisters; limiting instrumental ADL Grade 2 Bullous dermatitisPTCTCAE E13619 Grade 2 Bullous dermatitis Grade 2 Burn NCIMedical intervention; minimal debridement indicated Grade 2 BurnPTCTCAE E11671 Grade 2 Burn Grade 2 Buttock pain NCIModerate pain; limiting instrumental ADL Grade 2 Buttock painPTCTCAE E12398 Grade 2 Buttock pain Grade 2 CD4 lymphocytes decreased NCI<500 - 200/mm3; <0.5 - 0.2 x 10e9 /L Grade 2 CD4 lymphocytes decreasedPTCTCAE E12124 Grade 2 CD4 lymphocytes decreased Grade 2 CPK increased NCI>2.5 x ULN - 5 x ULN Grade 2 CPK increasedPTCTCAE E12134 Grade 2 CPK increased Grade 2 Capillary leak syndrome NCISymptomatic; medical intervention indicated Grade 2 Capillary leak syndromePTCTCAE E13767 Grade 2 Capillary leak syndrome Grade 2 Carbon monoxide diffusing capacity decreased NCI6 - 8 units below LLN; for follow-up, an asymptomatic decrease of >5 - 8 units (ml/min/mm Hg) below the baseline value Grade 2 Carbon monoxide diffusing capacity decreasedPTCTCAE E12114 Grade 2 Carbon monoxide diffusing capacity decreased Grade 2 Cardiac disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Cardiac disorders - Other, specifyPTCTCAE E10106 Grade 2 Cardiac disorders - Other, specify Grade 2 Cataract NCISymptomatic; moderate decrease in visual acuity (20/40 or better) Grade 2 CataractPTCTCAE E10352 Grade 2 Cataract Grade 2 Catheter related infection NCILocalized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Catheter related infectionPTCTCAE E11329 Grade 2 Catheter related infection Grade 2 Cecal hemorrhage NCIModerate symptoms; medical intervention or minor cauterization indicated Grade 2 Cecal hemorrhagePTCTCAE E10513 Grade 2 Cecal hemorrhage Grade 2 Central nervous system necrosis NCIModerate symptoms; corticosteroids indicated Grade 2 Central nervous system necrosisPTCTCAE E12607 Grade 2 Central nervous system necrosis Grade 2 Cerebrospinal fluid leakage NCIPost-craniotomy: moderate symptoms; medical intervention indicated; Post-lumbar puncture: persistent moderate symptoms; blood patch indicated Grade 2 Cerebrospinal fluid leakagePTCTCAE E12613 Grade 2 Cerebrospinal fluid leakage Grade 2 Cervicitis infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Cervicitis infectionPTCTCAE E11338 Grade 2 Cervicitis infection Grade 2 Cheilitis NCIModerate symptoms; limiting instrumental ADL Grade 2 CheilitisPTCTCAE E10519 Grade 2 Cheilitis Grade 2 Chest pain - cardiac NCIModerate pain; limiting instrumental ADL Grade 2 Chest pain - cardiacPTCTCAE E10112 Grade 2 Chest pain - cardiac Grade 2 Chest wall pain NCIModerate pain; limiting instrumental ADL Grade 2 Chest wall painPTCTCAE E12402 Grade 2 Chest wall pain Grade 2 Chills NCIModerate tremor of the entire body; narcotics indicated Grade 2 ChillsPTCTCAE E11076 Grade 2 Chills Grade 2 Cholecystitis NCISymptomatic; medical intervention indicated Grade 2 CholecystitisPTCTCAE E11185 Grade 2 Cholecystitis Grade 2 Cholesterol high NCI>300 - 400 mg/dL; >7.75 - 10.34 mmol/L Grade 2 Cholesterol highPTCTCAE E12129 Grade 2 Cholesterol high Grade 2 Chronic kidney disease NCIeGFR or CrCl 59 - 30 ml/min/1.73 m2 Grade 2 Chronic kidney diseasePTCTCAE E12990 Grade 2 Chronic kidney disease Grade 2 Chylothorax NCISymptomatic; thoracentesis or tube drainage indicated Grade 2 ChylothoraxPTCTCAE E13360 Grade 2 Chylothorax Grade 2 Cognitive disturbance NCIModerate cognitive disability; interfering with work/school/life performance but capable of independent living; specialized resources on part time basis indicated Grade 2 Cognitive disturbancePTCTCAE E12619 Grade 2 Cognitive disturbance Grade 2 Colitis NCIAbdominal pain; mucus or blood in stool Grade 2 ColitisPTCTCAE E10523 Grade 2 Colitis Grade 2 Colonic fistula NCISymptomatic; altered GI function Grade 2 Colonic fistulaPTCTCAE E10529 Grade 2 Colonic fistula Grade 2 Colonic hemorrhage NCIModerate symptoms; medical intervention or minor cauterization indicated Grade 2 Colonic hemorrhagePTCTCAE E10535 Grade 2 Colonic hemorrhage Grade 2 Colonic obstruction NCISymptomatic; altered GI function Grade 2 Colonic obstructionPTCTCAE E10541 Grade 2 Colonic obstruction Grade 2 Colonic perforation NCISymptomatic; medical intervention indicated Grade 2 Colonic perforationPTCTCAE E10546 Grade 2 Colonic perforation Grade 2 Colonic stenosis NCISymptomatic; altered GI function Grade 2 Colonic stenosisPTCTCAE E10552 Grade 2 Colonic stenosis Grade 2 Colonic ulcer NCISymptomatic; altered GI function Grade 2 Colonic ulcerPTCTCAE E10558 Grade 2 Colonic ulcer Grade 2 Concentration impairment NCIModerate impairment in attention or decreased level of concentration; limiting instrumental ADL Grade 2 Concentration impairmentPTCTCAE E12623 Grade 2 Concentration impairment Grade 2 Conduction disorder NCIModerate symptoms Grade 2 Conduction disorderPTCTCAE E10116 Grade 2 Conduction disorder Grade 2 Confusion NCIModerate disorientation; limiting instrumental ADL Grade 2 ConfusionPTCTCAE E12891 Grade 2 Confusion Grade 2 Congenital, familial and genetic disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Congenital, familial and genetic disorders - Other, specifyPTCTCAE E10252 Grade 2 Congenital, familial and genetic disorders - Other, specify Grade 2 Conjunctivitis NCISymptomatic; topical intervention indicated (e.g., antibiotics); limiting instrumental ADL Grade 2 ConjunctivitisPTCTCAE E10357 Grade 2 Conjunctivitis Grade 2 Conjunctivitis infective NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Conjunctivitis infectivePTCTCAE E11343 Grade 2 Conjunctivitis infective Grade 2 Constipation NCIPersistent symptoms with regular use of laxatives or enemas; limiting instrumental ADL Grade 2 ConstipationPTCTCAE E10564 Grade 2 Constipation Grade 2 Corneal infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Corneal infectionPTCTCAE E11348 Grade 2 Corneal infection Grade 2 Corneal ulcer NCISymptomatic; medical intervention indicated (e.g., topical agents); limiting instrumental ADL Grade 2 Corneal ulcerPTCTCAE E10360 Grade 2 Corneal ulcer Grade 2 Cough NCIModerate symptoms, medical intervention indicated; limiting instrumental ADL Grade 2 CoughPTCTCAE E13366 Grade 2 Cough Grade 2 Creatinine increased NCI>1.5 - 3.0 x baseline; >1.5 - 3.0 x ULN Grade 2 Creatinine increasedPTCTCAE E12139 Grade 2 Creatinine increased Grade 2 Cushingoid NCIModerate symptoms; medical intervention indicated Grade 2 CushingoidPTCTCAE E10306 Grade 2 Cushingoid Grade 2 Cystitis noninfective NCIModerate hematuria; moderate increase in frequency, urgency, dysuria, nocturia or incontinence; urinary catheter placement or bladder irrigation indicated; limiting instrumental ADL Grade 2 Cystitis noninfectivePTCTCAE E12996 Grade 2 Cystitis noninfective Grade 2 Cytokine release syndrome NCITherapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for <=24 hrs Grade 2 Cytokine release syndromePTCTCAE E11266 Grade 2 Cytokine release syndrome Grade 2 Dehydration NCIIV fluids indicated <24 hrs Grade 2 DehydrationPTCTCAE E12260 Grade 2 Dehydration Grade 2 Delayed orgasm NCIDelay in achieving orgasm adversely affecting relationship Grade 2 Delayed orgasmPTCTCAE E12897 Grade 2 Delayed orgasm Grade 2 Delayed puberty NCINo breast development by age 13 yrs for females; testes volume of <3 cc or no Tanner Stage 2 development by age 14.5 yrs for males Grade 2 Delayed pubertyPTCTCAE E10309 Grade 2 Delayed puberty Grade 2 Delirium NCIModerate and acute confusional state; limiting instrumental ADL Grade 2 DeliriumPTCTCAE E12900 Grade 2 Delirium Grade 2 Delusions NCIModerate delusional symptoms Grade 2 DelusionsPTCTCAE E12905 Grade 2 Delusions Grade 2 Dental caries NCIDental caries involving the root Grade 2 Dental cariesPTCTCAE E10570 Grade 2 Dental caries Grade 2 Depressed level of consciousness NCISedation; slow response to stimuli; limiting instrumental ADL Grade 2 Depressed level of consciousnessPTCTCAE E12627 Grade 2 Depressed level of consciousness Grade 2 Depression NCIModerate depressive symptoms; limiting instrumental ADL Grade 2 DepressionPTCTCAE E12911 Grade 2 Depression Grade 2 Dermatitis radiation NCIModerate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema Grade 2 Dermatitis radiationPTCTCAE E11677 Grade 2 Dermatitis radiation Grade 2 Diarrhea NCIIncrease of 4 - 6 stools per day over baseline; moderate increase in ostomy output compared to baseline Grade 2 DiarrheaPTCTCAE E10574 Grade 2 Diarrhea Grade 2 Disseminated intravascular coagulation NCILaboratory findings with no bleeding Grade 2 Disseminated intravascular coagulationPTCTCAE E10029 Grade 2 Disseminated intravascular coagulation Grade 2 Dizziness NCIModerate unsteadiness or sensation of movement; limiting instrumental ADL Grade 2 DizzinessPTCTCAE E12633 Grade 2 Dizziness Grade 2 Dry eye NCISymptomatic; multiple agents indicated; limiting instrumental ADL Grade 2 Dry eyePTCTCAE E10365 Grade 2 Dry eye Grade 2 Dry mouth NCIModerate symptoms; oral intake alterations (e.g., copious water, other lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min Grade 2 Dry mouthPTCTCAE E10580 Grade 2 Dry mouth Grade 2 Dry skin NCICovering 10 - 30% BSA and associated with erythema or pruritus; limiting instrumental ADL Grade 2 Dry skinPTCTCAE E13625 Grade 2 Dry skin Grade 2 Duodenal fistula NCISymptomatic; altered GI function Grade 2 Duodenal fistulaPTCTCAE E10584 Grade 2 Duodenal fistula Grade 2 Duodenal hemorrhage NCIModerate symptoms; medical intervention or minor cauterization indicated Grade 2 Duodenal hemorrhagePTCTCAE E10590 Grade 2 Duodenal hemorrhage Grade 2 Duodenal infection NCIModerate symptoms; medical intervention indicated (e.g., oral antibiotics) Grade 2 Duodenal infectionPTCTCAE E11361 Grade 2 Duodenal infection Grade 2 Duodenal obstruction NCISymptomatic; altered GI function Grade 2 Duodenal obstructionPTCTCAE E10596 Grade 2 Duodenal obstruction Grade 2 Duodenal perforation NCISymptomatic; medical intervention indicated Grade 2 Duodenal perforationPTCTCAE E10601 Grade 2 Duodenal perforation Grade 2 Duodenal stenosis NCISymptomatic; altered GI function Grade 2 Duodenal stenosisPTCTCAE E10607 Grade 2 Duodenal stenosis Grade 2 Duodenal ulcer NCIModerate symptoms; medical intervention indicated; limiting instrumental ADL Grade 2 Duodenal ulcerPTCTCAE E10613 Grade 2 Duodenal ulcer Grade 2 Dysarthria NCIModerate impairment of articulation or slurred speech Grade 2 DysarthriaPTCTCAE E12637 Grade 2 Dysarthria Grade 2 Dysesthesia NCIModerate sensory alteration; limiting instrumental ADL Grade 2 DysesthesiaPTCTCAE E12641 Grade 2 Dysesthesia Grade 2 Dysgeusia NCIAltered taste with change in diet (e.g., oral supplements); noxious or unpleasant taste; loss of taste Grade 2 DysgeusiaPTCTCAE E12645 Grade 2 Dysgeusia Grade 2 Dysmenorrhea NCIModerate symptoms; limiting instrumental ADL Grade 2 DysmenorrheaPTCTCAE E13079 Grade 2 Dysmenorrhea Grade 2 Dyspareunia NCIModerate discomfort or pain associated with vaginal penetration; discomfort or pain partially relieved with use of vaginal lubricants or estrogen Grade 2 DyspareuniaPTCTCAE E13083 Grade 2 Dyspareunia Grade 2 Dyspepsia NCIModerate symptoms; medical intervention indicated Grade 2 DyspepsiaPTCTCAE E10619 Grade 2 Dyspepsia Grade 2 Dysphagia NCISymptomatic and altered eating/swallowing Grade 2 DysphagiaPTCTCAE E10623 Grade 2 Dysphagia Grade 2 Dysphasia NCIModerate receptive or expressive characteristics; impairing ability to communicate spontaneously Grade 2 DysphasiaPTCTCAE E12648 Grade 2 Dysphasia Grade 2 Dyspnea NCIShortness of breath with minimal exertion; limiting instrumental ADL Grade 2 DyspneaPTCTCAE E13370 Grade 2 Dyspnea Grade 2 Ear and labyrinth disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Ear and labyrinth disorders - Other, specifyPTCTCAE E10258 Grade 2 Ear and labyrinth disorders - Other, specify Grade 2 Ear pain NCIModerate pain; limiting instrumental ADL Grade 2 Ear painPTCTCAE E10264 Grade 2 Ear pain Grade 2 Edema face NCIModerate localized facial edema; limiting instrumental ADL Grade 2 Edema facePTCTCAE E11084 Grade 2 Edema face Grade 2 Edema limbs NCI>10 - 30% inter-limb discrepancy in volume or circumference at point of greatest visible difference; readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour; limiting instrumental ADL Grade 2 Edema limbsPTCTCAE E11088 Grade 2 Edema limbs Grade 2 Edema trunk NCIReadily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour; limiting instrumental ADL Grade 2 Edema trunkPTCTCAE E11092 Grade 2 Edema trunk Grade 2 Ejaculation disorder NCIAnejaculation or retrograde ejaculation Grade 2 Ejaculation disorderPTCTCAE E13087 Grade 2 Ejaculation disorder Grade 2 Ejection fraction decreased NCIResting ejection fraction (EF) 50 - 40%; 10 - 19% drop from baseline Grade 2 Ejection fraction decreasedPTCTCAE E12143 Grade 2 Ejection fraction decreased Grade 2 Electrocardiogram QT corrected interval prolonged NCIQTc 481 - 500 ms Grade 2 Electrocardiogram QT corrected interval prolongedPTCTCAE E12148 Grade 2 Electrocardiogram QT corrected interval prolonged Grade 2 Encephalopathy NCIModerate symptoms; limiting instrumental ADL Grade 2 EncephalopathyPTCTCAE E12654 Grade 2 Encephalopathy Grade 2 Endocrine disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Endocrine disorders - Other, specifyPTCTCAE E10313 Grade 2 Endocrine disorders - Other, specify Grade 2 Endophthalmitis NCILocal intervention indicated Grade 2 EndophthalmitisPTCTCAE E11378 Grade 2 Endophthalmitis Grade 2 Enterocolitis NCIAbdominal pain; mucus or blood in stool Grade 2 EnterocolitisPTCTCAE E10629 Grade 2 Enterocolitis Grade 2 Enterocolitis infectious NCIPassage of >3 unformed stools per 24 hrs or duration of illness >48 hrs; moderate abdominal pain Grade 2 Enterocolitis infectiousPTCTCAE E11382 Grade 2 Enterocolitis infectious Grade 2 Enterovesical fistula NCISymptomatic; noninvasive intervention indicated Grade 2 Enterovesical fistulaPTCTCAE E10635 Grade 2 Enterovesical fistula Grade 2 Epistaxis NCIModerate symptoms; medical intervention indicated (e.g., nasal packing, cauterization; topical vasoconstrictors) Grade 2 EpistaxisPTCTCAE E13376 Grade 2 Epistaxis Grade 2 Erectile dysfunction NCIDecrease in erectile function (frequency/rigidity of erections), erectile intervention indicated, (e.g., medication or mechanical devices such as penile pump) Grade 2 Erectile dysfunctionPTCTCAE E13090 Grade 2 Erectile dysfunction Grade 2 Erythema multiforme NCITarget lesions covering 10 - 30% BSA and associated with skin tenderness Grade 2 Erythema multiformePTCTCAE E13629 Grade 2 Erythema multiforme Grade 2 Erythroderma NCIErythema covering >90% BSA without associated symptoms; limiting instrumental ADL Grade 2 ErythrodermaPTCTCAE E13634 Grade 2 Erythroderma Grade 2 Esophageal anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Esophageal anastomotic leakPTCTCAE E11683 Grade 2 Esophageal anastomotic leak Grade 2 Esophageal fistula NCISymptomatic; altered GI function Grade 2 Esophageal fistulaPTCTCAE E10641 Grade 2 Esophageal fistula Grade 2 Esophageal hemorrhage NCIModerate symptoms; medical intervention or minor cauterization indicated Grade 2 Esophageal hemorrhagePTCTCAE E10647 Grade 2 Esophageal hemorrhage Grade 2 Esophageal infection NCILocal intervention indicated (e.g., oral antibiotic, antifungal, antiviral) Grade 2 Esophageal infectionPTCTCAE E11387 Grade 2 Esophageal infection Grade 2 Esophageal obstruction NCISymptomatic; altered GI function; limiting instrumental ADL Grade 2 Esophageal obstructionPTCTCAE E10657 Grade 2 Esophageal obstruction Grade 2 Esophageal pain NCIModerate pain; limiting instrumental ADL Grade 2 Esophageal painPTCTCAE E10663 Grade 2 Esophageal pain Grade 2 Esophageal perforation NCISymptomatic; medical intervention indicated Grade 2 Esophageal perforationPTCTCAE E10666 Grade 2 Esophageal perforation Grade 2 Esophageal stenosis NCISymptomatic; altered GI function Grade 2 Esophageal stenosisPTCTCAE E10672 Grade 2 Esophageal stenosis Grade 2 Esophageal ulcer NCISymptomatic; altered GI function; limiting instrumental ADL Grade 2 Esophageal ulcerPTCTCAE E10678 Grade 2 Esophageal ulcer Grade 2 Esophageal varices hemorrhage NCISelf-limited; intervention not indicated Grade 2 Esophageal varices hemorrhagePTCTCAE E10683 Grade 2 Esophageal varices hemorrhage Grade 2 Esophagitis NCISymptomatic; altered eating/swallowing; oral supplements indicated Grade 2 EsophagitisPTCTCAE E10689 Grade 2 Esophagitis Grade 2 Euphoria NCIModerate mood elevation Grade 2 EuphoriaPTCTCAE E12917 Grade 2 Euphoria Grade 2 Exostosis NCISymptomatic; limiting instrumental ADL Grade 2 ExostosisPTCTCAE E12406 Grade 2 Exostosis Grade 2 External ear inflammation NCIExternal otitis with moist desquamation, edema, enhanced cerumen or discharge; tympanic membrane perforation; tympanostomy Grade 2 External ear inflammationPTCTCAE E10268 Grade 2 External ear inflammation Grade 2 External ear pain NCIModerate pain; limiting instrumental ADL Grade 2 External ear painPTCTCAE E10274 Grade 2 External ear pain Grade 2 Extraocular muscle paresis NCISymptomatic; limiting instrumental ADL Grade 2 Extraocular muscle paresisPTCTCAE E10369 Grade 2 Extraocular muscle paresis Grade 2 Extrapyramidal disorder NCIModerate involuntary movements; limiting instrumental ADL Grade 2 Extrapyramidal disorderPTCTCAE E12660 Grade 2 Extrapyramidal disorder Grade 2 Eye disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Eye disorders - Other, specifyPTCTCAE E10373 Grade 2 Eye disorders - Other, specify Grade 2 Eye infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Eye infectionPTCTCAE E11392 Grade 2 Eye infection Grade 2 Eye pain NCIModerate pain; limiting instrumental ADL Grade 2 Eye painPTCTCAE E10378 Grade 2 Eye pain Grade 2 Eyelid function disorder NCISymptomatic; nonoperative intervention indicated; limiting instrumental ADL Grade 2 Eyelid function disorderPTCTCAE E10382 Grade 2 Eyelid function disorder Grade 2 Facial muscle weakness NCIModerate symptoms; limiting instrumental ADL Grade 2 Facial muscle weaknessPTCTCAE E12666 Grade 2 Facial muscle weakness Grade 2 Facial nerve disorder NCIModerate symptoms; limiting instrumental ADL Grade 2 Facial nerve disorderPTCTCAE E12670 Grade 2 Facial nerve disorder Grade 2 Facial pain NCIModerate pain; limiting instrumental ADL Grade 2 Facial painPTCTCAE E11096 Grade 2 Facial pain Grade 2 Fall NCISymptomatic; noninvasive intervention indicated Grade 2 FallPTCTCAE E11689 Grade 2 Fall Grade 2 Fallopian tube anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Fallopian tube anastomotic leakPTCTCAE E11693 Grade 2 Fallopian tube anastomotic leak Grade 2 Fallopian tube obstruction NCIMild symptoms; elective intervention indicated Grade 2 Fallopian tube obstructionPTCTCAE E13094 Grade 2 Fallopian tube obstruction Grade 2 Fallopian tube perforation NCISymptomatic and intervention not indicated Grade 2 Fallopian tube perforationPTCTCAE E11699 Grade 2 Fallopian tube perforation Grade 2 Fallopian tube stenosis NCISymptomatic and intervention not indicated Grade 2 Fallopian tube stenosisPTCTCAE E13098 Grade 2 Fallopian tube stenosis Grade 2 Fat atrophy NCICovering 10 - 30% BSA and associated with erythema or tenderness; limiting instrumental ADL Grade 2 Fat atrophyPTCTCAE E13640 Grade 2 Fat atrophy Grade 2 Fatigue NCIFatigue not relieved by rest; limiting instrumental ADL Grade 2 FatiguePTCTCAE E11100 Grade 2 Fatigue Grade 2 Fecal incontinence NCIDaily use of pads required Grade 2 Fecal incontinencePTCTCAE E10695 Grade 2 Fecal incontinence Grade 2 Female genital tract fistula NCISymptomatic and intervention not indicated Grade 2 Female genital tract fistulaPTCTCAE E13104 Grade 2 Female genital tract fistula Grade 2 Feminization acquired NCIModerate symptoms; medical intervention indicated Grade 2 Feminization acquiredPTCTCAE E13110 Grade 2 Feminization acquired Grade 2 Fetal growth retardation NCI<10% percentile of weight for gestational age Grade 2 Fetal growth retardationPTCTCAE E12858 Grade 2 Fetal growth retardation Grade 2 Fever NCI>39.0 - 40.0 degrees C (102.3 - 104.0 degrees F) Grade 2 FeverPTCTCAE E11104 Grade 2 Fever Grade 2 Fibrinogen decreased NCI<0.75 - 0.5 x LLN or 25 - <50% decrease from baseline Grade 2 Fibrinogen decreasedPTCTCAE E12153 Grade 2 Fibrinogen decreased Grade 2 Fibrosis deep connective tissue NCIModerate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL Grade 2 Fibrosis deep connective tissuePTCTCAE E12410 Grade 2 Fibrosis deep connective tissue Grade 2 Flank pain NCIModerate pain; limiting instrumental ADL Grade 2 Flank painPTCTCAE E12416 Grade 2 Flank pain Grade 2 Flashing lights NCILimiting instrumental ADL Grade 2 Flashing lightsPTCTCAE E10386 Grade 2 Flashing lights Grade 2 Flatulence NCIModerate; persistent; psychosocial sequelae Grade 2 FlatulencePTCTCAE E10699 Grade 2 Flatulence Grade 2 Floaters NCILimiting instrumental ADL Grade 2 FloatersPTCTCAE E10390 Grade 2 Floaters Grade 2 Flu like symptoms NCIModerate symptoms; limiting instrumental ADL Grade 2 Flu like symptomsPTCTCAE E11110 Grade 2 Flu like symptoms Grade 2 Flushing NCIModerate symptoms; medical intervention indicated; limiting instrumental ADL Grade 2 FlushingPTCTCAE E13773 Grade 2 Flushing Grade 2 Forced expiratory volume decreased NCIFEV1 60 - 69% Grade 2 Forced expiratory volume decreasedPTCTCAE E12158 Grade 2 Forced expiratory volume decreased Grade 2 Fracture NCISymptomatic but non-displaced; immobilization indicated Grade 2 FracturePTCTCAE E11705 Grade 2 Fracture Grade 2 GGT increased NCI>2.5 - 5.0 x ULN Grade 2 GGT increasedPTCTCAE E12163 Grade 2 GGT increased Grade 2 Gait disturbance NCIModerate change in gait (e.g., wide-based, limping or hobbling); assistive device indicated; limiting instrumental ADL Grade 2 Gait disturbancePTCTCAE E11114 Grade 2 Gait disturbance Grade 2 Gallbladder fistula NCISymptomatic and intervention not indicated Grade 2 Gallbladder fistulaPTCTCAE E11191 Grade 2 Gallbladder fistula Grade 2 Gallbladder obstruction NCISymptomatic; altered GI function; IV fluids indicated <24 hrs Grade 2 Gallbladder obstructionPTCTCAE E11200 Grade 2 Gallbladder obstruction Grade 2 Gallbladder pain NCIModerate pain; limiting instrumental ADL Grade 2 Gallbladder painPTCTCAE E11206 Grade 2 Gallbladder pain Grade 2 Gastric anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Gastric anastomotic leakPTCTCAE E11711 Grade 2 Gastric anastomotic leak Grade 2 Gastric fistula NCISymptomatic; altered GI function Grade 2 Gastric fistulaPTCTCAE E10702 Grade 2 Gastric fistula Grade 2 Gastric hemorrhage NCIModerate symptoms; medical intervention or minor cauterization indicated Grade 2 Gastric hemorrhagePTCTCAE E10708 Grade 2 Gastric hemorrhage Grade 2 Gastric perforation NCISymptomatic; medical intervention indicated Grade 2 Gastric perforationPTCTCAE E10717 Grade 2 Gastric perforation Grade 2 Gastric stenosis NCISymptomatic; altered GI function Grade 2 Gastric stenosisPTCTCAE E10723 Grade 2 Gastric stenosis Grade 2 Gastric ulcer NCISymptomatic; altered GI function; medical intervention indicated; limiting instrumental ADL Grade 2 Gastric ulcerPTCTCAE E10729 Grade 2 Gastric ulcer Grade 2 Gastritis NCISymptomatic; altered GI function; medical intervention indicated Grade 2 GastritisPTCTCAE E10735 Grade 2 Gastritis Grade 2 Gastroesophageal reflux disease NCIModerate symptoms; medical intervention indicated Grade 2 Gastroesophageal reflux diseasePTCTCAE E10741 Grade 2 Gastroesophageal reflux disease Grade 2 Gastrointestinal anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Gastrointestinal anastomotic leakPTCTCAE E11717 Grade 2 Gastrointestinal anastomotic leak Grade 2 Gastrointestinal disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Gastrointestinal disorders - Other, specifyPTCTCAE E10745 Grade 2 Gastrointestinal disorders - Other, specify Grade 2 Gastrointestinal fistula NCISymptomatic; altered GI function Grade 2 Gastrointestinal fistulaPTCTCAE E10751 Grade 2 Gastrointestinal fistula Grade 2 Gastrointestinal pain NCIModerate pain; limiting instrumental ADL Grade 2 Gastrointestinal painPTCTCAE E10757 Grade 2 Gastrointestinal pain Grade 2 Gastrointestinal stoma necrosis NCISuperficial necrosis; intervention not indicated Grade 2 Gastrointestinal stoma necrosisPTCTCAE E11722 Grade 2 Gastrointestinal stoma necrosis Grade 2 Gastroparesis NCIModerate symptoms; able to maintain nutrition with dietary and lifestyle modifications; may need pharmacologic intervention Grade 2 GastroparesisPTCTCAE E10761 Grade 2 Gastroparesis Grade 2 General disorders and administration site conditions - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 General disorders and administration site conditions - Other, specifyPTCTCAE E11118 Grade 2 General disorders and administration site conditions - Other, specify Grade 2 Generalized muscle weakness NCISymptomatic; weakness evident on physical exam; weakness limiting instrumental ADL Grade 2 Generalized muscle weaknessPTCTCAE E12420 Grade 2 Generalized muscle weakness Grade 2 Genital edema NCIReadily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour Grade 2 Genital edemaPTCTCAE E13113 Grade 2 Genital edema Grade 2 Gingival pain NCIModerate pain interfering with oral intake Grade 2 Gingival painPTCTCAE E10765 Grade 2 Gingival pain Grade 2 Glaucoma NCIEIOP causing early visual field deficits; multiple topical or oral agents indicated; limiting instrumental ADL Grade 2 GlaucomaPTCTCAE E10394 Grade 2 Glaucoma Grade 2 Glossopharyngeal nerve disorder NCIModerate symptoms; limiting instrumental ADL Grade 2 Glossopharyngeal nerve disorderPTCTCAE E12674 Grade 2 Glossopharyngeal nerve disorder Grade 2 Glucose intolerance NCISymptomatic; dietary modification or oral agent indicated Grade 2 Glucose intolerancePTCTCAE E12266 Grade 2 Glucose intolerance Grade 2 Growth accelerated NCI>= +2 SD (standard deviation) above mid parental height or target height Grade 2 Growth acceleratedPTCTCAE E10318 Grade 2 Growth accelerated Grade 2 Growth hormone abnormal NCISymptomatic; medical intervention indicated; limiting instrumental ADL Grade 2 Growth hormone abnormalPTCTCAE E12168 Grade 2 Growth hormone abnormal Grade 2 Growth suppression NCIReduction in growth velocity by 30 - 49% ideally measured over the period of a year or 0 - 49% reduction in growth from the baseline growth curve Grade 2 Growth suppressionPTCTCAE E12424 Grade 2 Growth suppression Grade 2 Gum infection NCIModerate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Gum infectionPTCTCAE E11402 Grade 2 Gum infection Grade 2 Gynecomastia NCISymptomatic (e.g., pain or psychosocial impact) Grade 2 GynecomastiaPTCTCAE E13117 Grade 2 Gynecomastia Grade 2 Hallucinations NCIModerate hallucinations Grade 2 HallucinationsPTCTCAE E12921 Grade 2 Hallucinations Grade 2 Head soft tissue necrosis NCILocal wound care; medical intervention indicated (e.g., dressings or topical medications) Grade 2 Head soft tissue necrosisPTCTCAE E12427 Grade 2 Head soft tissue necrosis Grade 2 Headache NCIModerate pain; limiting instrumental ADL Grade 2 HeadachePTCTCAE E12680 Grade 2 Headache Grade 2 Hearing impaired NCIAdults enrolled in Monitoring Program (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift of >25 dB averaged at 2 contiguous test frequencies in at least one ear. Adults not enrolled in Monitoring Program: hearing loss but hearing aid or intervention not indicated; limiting instrumental ADL. Pediatric (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift >20 dB at 4 kHz and above in at least one ear. Grade 2 Hearing impairedPTCTCAE E10278 Grade 2 Hearing impaired Grade 2 Heart failure NCISymptoms with mild to moderate activity or exertion Grade 2 Heart failurePTCTCAE E10126 Grade 2 Heart failure Grade 2 Hematoma NCIMinimally invasive evacuation or aspiration indicated Grade 2 HematomaPTCTCAE E13777 Grade 2 Hematoma Grade 2 Hematosalpinx NCIModerate bleeding; medical intervention indicated Grade 2 HematosalpinxPTCTCAE E13121 Grade 2 Hematosalpinx Grade 2 Hematuria NCISymptomatic; urinary catheter or bladder irrigation indicated; limiting instrumental ADL Grade 2 HematuriaPTCTCAE E13002 Grade 2 Hematuria Grade 2 Hemoglobin increased NCIIncrease in >2 - 4 gm/dL above ULN or above baseline if baseline is above ULN Grade 2 Hemoglobin increasedPTCTCAE E12173 Grade 2 Hemoglobin increased Grade 2 Hemolysis NCIEvidence of hemolysis and >=2 gm decrease in hemoglobin. Grade 2 HemolysisPTCTCAE E10039 Grade 2 Hemolysis Grade 2 Hemorrhoidal hemorrhage NCIModerate symptoms; medical intervention or minor cauterization indicated Grade 2 Hemorrhoidal hemorrhagePTCTCAE E10769 Grade 2 Hemorrhoidal hemorrhage Grade 2 Hemorrhoids NCISymptomatic; banding or medical intervention indicated Grade 2 HemorrhoidsPTCTCAE E10775 Grade 2 Hemorrhoids Grade 2 Hepatic hemorrhage NCISymptomatic; medical intervention indicated Grade 2 Hepatic hemorrhagePTCTCAE E11217 Grade 2 Hepatic hemorrhage Grade 2 Hepatic pain NCIModerate pain; limiting instrumental ADL Grade 2 Hepatic painPTCTCAE E11226 Grade 2 Hepatic pain Grade 2 Hepatobiliary disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Hepatobiliary disorders - Other, specifyPTCTCAE E11230 Grade 2 Hepatobiliary disorders - Other, specify Grade 2 Hiccups NCIModerate symptoms; medical intervention indicated; limiting instrumental ADL Grade 2 HiccupsPTCTCAE E13382 Grade 2 Hiccups Grade 2 Hip fracture NCIHairline fracture; mild pain; limiting instrumental ADL; non-surgical intervention indicated Grade 2 Hip fracturePTCTCAE E11727 Grade 2 Hip fracture Grade 2 Hirsutism NCIIn women, increase in length, thickness or density of hair in a male distribution that requires daily shaving or consistent destructive means of hair removal to camouflage; associated with psychosocial impact Grade 2 HirsutismPTCTCAE E13644 Grade 2 Hirsutism Grade 2 Hoarseness NCIModerate or persistent voice changes; may require occasional repetition but understandable on telephone; medical evaluation indicated Grade 2 HoarsenessPTCTCAE E13386 Grade 2 Hoarseness Grade 2 Hot flashes NCIModerate symptoms; limiting instrumental ADL Grade 2 Hot flashesPTCTCAE E13783 Grade 2 Hot flashes Grade 2 Hydrocephalus NCIModerate symptoms; intervention not indicated Grade 2 HydrocephalusPTCTCAE E12684 Grade 2 Hydrocephalus Grade 2 Hypercalcemia NCICorrected serum calcium of >11.5 - 12.5 mg/dL; >2.9 - 3.1 mmol/L; Ionized calcium >1.5 - 1.6 mmol/L; symptomatic Grade 2 HypercalcemiaPTCTCAE E12272 Grade 2 Hypercalcemia Grade 2 Hyperglycemia NCIFasting glucose value >160 - 250 mg/dL; Fasting glucose value >8.9 - 13.9 mmol/L Grade 2 HyperglycemiaPTCTCAE E12278 Grade 2 Hyperglycemia Grade 2 Hyperhidrosis NCIInvolving >1 site; patient seeks medical intervention; associated with psychosocial impact Grade 2 HyperhidrosisPTCTCAE E13647 Grade 2 Hyperhidrosis Grade 2 Hyperkalemia NCI>5.5 - 6.0 mmol/L Grade 2 HyperkalemiaPTCTCAE E12284 Grade 2 Hyperkalemia Grade 2 Hypernatremia NCI>150 - 155 mmol/L Grade 2 HypernatremiaPTCTCAE E12295 Grade 2 Hypernatremia Grade 2 Hyperparathyroidism NCIModerate symptoms; medical intervention indicated Grade 2 HyperparathyroidismPTCTCAE E10321 Grade 2 Hyperparathyroidism Grade 2 Hypersomnia NCIModerate increased need for sleep Grade 2 HypersomniaPTCTCAE E12690 Grade 2 Hypersomnia Grade 2 Hypertension NCIStage 1 hypertension (systolic BP 140 - 159 mm Hg or diastolic BP 90 - 99 mm Hg); medical intervention indicated; recurrent or persistent (>=24 hrs); symptomatic increase by >20 mm Hg (diastolic) or to >140/90 mm Hg if previously WNL; monotherapy indicated Pediatric: recurrent or persistent (>=24 hrs) BP >ULN; monotherapy indicated Grade 2 HypertensionPTCTCAE E13787 Grade 2 Hypertension Grade 2 Hyperthyroidism NCISymptomatic; thyroid suppression therapy indicated; limiting instrumental ADL Grade 2 HyperthyroidismPTCTCAE E10324 Grade 2 Hyperthyroidism Grade 2 Hypertrichosis NCIIncrease in length, thickness or density of hair at least on the usual exposed areas of the body [face (not limited to beard/moustache area) plus/minus arms] that requires frequent shaving or use of destructive means of hair removal to camouflage; associated with psychosocial impact Grade 2 HypertrichosisPTCTCAE E13651 Grade 2 Hypertrichosis Grade 2 Hypertriglyceridemia NCI>300 mg/dL - 500 mg/dL; >3.42 mmol/L - 5.7 mmol/L Grade 2 HypertriglyceridemiaPTCTCAE E12301 Grade 2 Hypertriglyceridemia Grade 2 Hypoalbuminemia NCI<3 - 2 g/dL; <30 - 20 g/L Grade 2 HypoalbuminemiaPTCTCAE E12312 Grade 2 Hypoalbuminemia Grade 2 Hypocalcemia NCICorrected serum calcium of <8.0 - 7.0 mg/dL; <2.0 - 1.75 mmol/L; Ionized calcium <1.0 - 0.9 mmol/L; symptomatic Grade 2 HypocalcemiaPTCTCAE E12318 Grade 2 Hypocalcemia Grade 2 Hypoglossal nerve disorder NCIModerate symptoms; limiting instrumental ADL Grade 2 Hypoglossal nerve disorderPTCTCAE E12694 Grade 2 Hypoglossal nerve disorder Grade 2 Hypoglycemia NCI<55 - 40 mg/dL; <3.0 - 2.2 mmol/L Grade 2 HypoglycemiaPTCTCAE E13874 Grade 2 Hypoglycemia Grade 2 Hypohidrosis NCISymptomatic; limiting instrumental ADL Grade 2 HypohidrosisPTCTCAE E13653 Grade 2 Hypohidrosis Grade 2 Hypokalemia NCI<LLN - 3.0 mmol/L; symptomatic; intervention indicated Grade 2 HypokalemiaPTCTCAE E12329 Grade 2 Hypokalemia Grade 2 Hypomagnesemia NCI<1.2 - 0.9 mg/dL; <0.5 - 0.4 mmol/L Grade 2 HypomagnesemiaPTCTCAE E12335 Grade 2 Hypomagnesemia Grade 2 Hypoparathyroidism NCIModerate symptoms; medical intervention indicated Grade 2 HypoparathyroidismPTCTCAE E10330 Grade 2 Hypoparathyroidism Grade 2 Hypophosphatemia NCI<2.5 - 2.0 mg/dL; <0.8 - 0.6 mmol/L Grade 2 HypophosphatemiaPTCTCAE E12346 Grade 2 Hypophosphatemia Grade 2 Hypotension NCINon-urgent medical intervention indicated Grade 2 HypotensionPTCTCAE E13793 Grade 2 Hypotension Grade 2 Hypothermia NCI35 - >32 degrees C; 95 - >89.6 degrees F Grade 2 HypothermiaPTCTCAE E11123 Grade 2 Hypothermia Grade 2 Hypothyroidism NCISymptomatic; thyroid replacement indicated; limiting instrumental ADL Grade 2 HypothyroidismPTCTCAE E10336 Grade 2 Hypothyroidism Grade 2 Hypoxia NCIDecreased oxygen saturation with exercise (e.g., pulse oximeter <88%); intermittent supplemental oxygen Grade 2 HypoxiaPTCTCAE E13389 Grade 2 Hypoxia Grade 2 INR increased NCI>1.5 - 2.5 x ULN; >1.5 - 2.5 times above baseline if on anticoagulation Grade 2 INR increasedPTCTCAE E12177 Grade 2 INR increased Grade 2 IVth nerve disorder NCIModerate symptoms; limiting instrumental ADL Grade 2 IVth nerve disorderPTCTCAE E12707 Grade 2 IVth nerve disorder Grade 2 Ileal fistula NCISymptomatic; altered GI function Grade 2 Ileal fistulaPTCTCAE E10779 Grade 2 Ileal fistula Grade 2 Ileal hemorrhage NCIModerate symptoms; medical intervention or minor cauterization indicated Grade 2 Ileal hemorrhagePTCTCAE E10785 Grade 2 Ileal hemorrhage Grade 2 Ileal obstruction NCISymptomatic; altered GI function; limiting instrumental ADL Grade 2 Ileal obstructionPTCTCAE E10791 Grade 2 Ileal obstruction Grade 2 Ileal perforation NCISymptomatic; medical intervention indicated Grade 2 Ileal perforationPTCTCAE E10796 Grade 2 Ileal perforation Grade 2 Ileal stenosis NCISymptomatic; altered GI function Grade 2 Ileal stenosisPTCTCAE E10802 Grade 2 Ileal stenosis Grade 2 Ileal ulcer NCISymptomatic; altered GI function Grade 2 Ileal ulcerPTCTCAE E10808 Grade 2 Ileal ulcer Grade 2 Ileus NCISymptomatic; altered GI function; bowel rest indicated Grade 2 IleusPTCTCAE E10813 Grade 2 Ileus Grade 2 Immune system disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Immune system disorders - Other, specifyPTCTCAE E11272 Grade 2 Immune system disorders - Other, specify Grade 2 Infections and infestations - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Infections and infestations - Other, specifyPTCTCAE E11417 Grade 2 Infections and infestations - Other, specify Grade 2 Infective myositis NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Infective myositisPTCTCAE E11422 Grade 2 Infective myositis Grade 2 Infusion related reaction NCITherapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for <=24 hrs Grade 2 Infusion related reactionPTCTCAE E11129 Grade 2 Infusion related reaction Grade 2 Infusion site extravasation NCIErythema with associated symptoms (e.g., edema, pain, induration, phlebitis) Grade 2 Infusion site extravasationPTCTCAE E11134 Grade 2 Infusion site extravasation Grade 2 Injection site reaction NCIPain; lipodystrophy; edema; phlebitis Grade 2 Injection site reactionPTCTCAE E11140 Grade 2 Injection site reaction Grade 2 Injury, poisoning and procedural complications - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Injury, poisoning and procedural complications - Other, specifyPTCTCAE E11749 Grade 2 Injury, poisoning and procedural complications - Other, specify Grade 2 Injury to superior vena cava NCISymptomatic; repair or revision not indicated Grade 2 Injury to superior vena cavaPTCTCAE E11743 Grade 2 Injury to superior vena cava Grade 2 Insomnia NCIModerate difficulty falling asleep, staying asleep or waking up early Grade 2 InsomniaPTCTCAE E12927 Grade 2 Insomnia Grade 2 Intestinal stoma leak NCISymptomatic; medical intervention indicated Grade 2 Intestinal stoma leakPTCTCAE E11755 Grade 2 Intestinal stoma leak Grade 2 Intestinal stoma obstruction NCISelf-limited; intervention not indicated Grade 2 Intestinal stoma obstructionPTCTCAE E11760 Grade 2 Intestinal stoma obstruction Grade 2 Intestinal stoma site bleeding NCIModerate bleeding; medical intervention indicated Grade 2 Intestinal stoma site bleedingPTCTCAE E11766 Grade 2 Intestinal stoma site bleeding Grade 2 Intra-abdominal hemorrhage NCIMedical intervention or minor cauterization indicated Grade 2 Intra-abdominal hemorrhagePTCTCAE E10818 Grade 2 Intra-abdominal hemorrhage Grade 2 Intracranial hemorrhage NCIModerate symptoms; medical intervention indicated Grade 2 Intracranial hemorrhagePTCTCAE E12698 Grade 2 Intracranial hemorrhage Grade 2 Intraoperative arterial injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative arterial injuryPTCTCAE E11772 Grade 2 Intraoperative arterial injury Grade 2 Intraoperative breast injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative breast injuryPTCTCAE E11778 Grade 2 Intraoperative breast injury Grade 2 Intraoperative ear injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative ear injuryPTCTCAE E11788 Grade 2 Intraoperative ear injury Grade 2 Intraoperative endocrine injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative endocrine injuryPTCTCAE E11794 Grade 2 Intraoperative endocrine injury Grade 2 Intraoperative gastrointestinal injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative gastrointestinal injuryPTCTCAE E11800 Grade 2 Intraoperative gastrointestinal injury Grade 2 Intraoperative head and neck injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative head and neck injuryPTCTCAE E11806 Grade 2 Intraoperative head and neck injury Grade 2 Intraoperative hepatobiliary injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative hepatobiliary injuryPTCTCAE E11816 Grade 2 Intraoperative hepatobiliary injury Grade 2 Intraoperative musculoskeletal injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative musculoskeletal injuryPTCTCAE E11822 Grade 2 Intraoperative musculoskeletal injury Grade 2 Intraoperative neurological injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative neurological injuryPTCTCAE E11828 Grade 2 Intraoperative neurological injury Grade 2 Intraoperative ocular injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative ocular injuryPTCTCAE E11834 Grade 2 Intraoperative ocular injury Grade 2 Intraoperative renal injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative renal injuryPTCTCAE E11840 Grade 2 Intraoperative renal injury Grade 2 Intraoperative reproductive tract injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative reproductive tract injuryPTCTCAE E11846 Grade 2 Intraoperative reproductive tract injury Grade 2 Intraoperative respiratory injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative respiratory injuryPTCTCAE E11852 Grade 2 Intraoperative respiratory injury Grade 2 Intraoperative skin injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative skin injuryPTCTCAE E11858 Grade 2 Intraoperative skin injury Grade 2 Intraoperative splenic injury NCIPrimary repair of injured organ/structure indicated Grade 2 Intraoperative splenic injuryPTCTCAE E11863 Grade 2 Intraoperative splenic injury Grade 2 Intraoperative urinary injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative urinary injuryPTCTCAE E11869 Grade 2 Intraoperative urinary injury Grade 2 Intraoperative venous injury NCIPartial resection of injured organ/structure indicated Grade 2 Intraoperative venous injuryPTCTCAE E11875 Grade 2 Intraoperative venous injury Grade 2 Investigations - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Investigations - Other, specifyPTCTCAE E12181 Grade 2 Investigations - Other, specify Grade 2 Iron overload NCIModerate symptoms; intervention not indicated Grade 2 Iron overloadPTCTCAE E12351 Grade 2 Iron overload Grade 2 Irregular menstruation NCIIntermittent menses with skipped menses for more than 4 to 6 months Grade 2 Irregular menstruationPTCTCAE E13127 Grade 2 Irregular menstruation Grade 2 Irritability NCIModerate; limiting instrumental ADL; increased attention indicated Grade 2 IrritabilityPTCTCAE E11146 Grade 2 Irritability Grade 2 Ischemia cerebrovascular NCIModerate symptoms Grade 2 Ischemia cerebrovascularPTCTCAE E12704 Grade 2 Ischemia cerebrovascular Grade 2 Jejunal fistula NCISymptomatic; altered GI function Grade 2 Jejunal fistulaPTCTCAE E10824 Grade 2 Jejunal fistula Grade 2 Jejunal hemorrhage NCIModerate symptoms; medical intervention or minor cauterization indicated Grade 2 Jejunal hemorrhagePTCTCAE E10830 Grade 2 Jejunal hemorrhage Grade 2 Jejunal obstruction NCISymptomatic; altered GI function; limiting instrumental ADL Grade 2 Jejunal obstructionPTCTCAE E10836 Grade 2 Jejunal obstruction Grade 2 Jejunal perforation NCISymptomatic; medical intervention indicated Grade 2 Jejunal perforationPTCTCAE E10841 Grade 2 Jejunal perforation Grade 2 Jejunal stenosis NCISymptomatic; altered GI function Grade 2 Jejunal stenosisPTCTCAE E10847 Grade 2 Jejunal stenosis Grade 2 Jejunal ulcer NCISymptomatic; altered GI function Grade 2 Jejunal ulcerPTCTCAE E10853 Grade 2 Jejunal ulcer Grade 2 Joint effusion NCISymptomatic; limiting instrumental ADL Grade 2 Joint effusionPTCTCAE E12433 Grade 2 Joint effusion Grade 2 Joint infection NCILocalized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral); needle aspiration indicated (single or multiple) Grade 2 Joint infectionPTCTCAE E11427 Grade 2 Joint infection Grade 2 Joint range of motion decreased NCI>25 - 50% decrease in ROM; limiting instrumental ADL Grade 2 Joint range of motion decreasedPTCTCAE E12437 Grade 2 Joint range of motion decreased Grade 2 Joint range of motion decreased cervical spine NCIRotation <60 degrees to right or left; <60 degrees of flexion Grade 2 Joint range of motion decreased cervical spinePTCTCAE E12441 Grade 2 Joint range of motion decreased cervical spine Grade 2 Joint range of motion decreased lumbar spine NCIPain with range of motion (ROM) in lumbar spine; requires a reaching aid to pick up a very light object from the floor Grade 2 Joint range of motion decreased lumbar spinePTCTCAE E12445 Grade 2 Joint range of motion decreased lumbar spine Grade 2 Keratitis NCISymptomatic; medical intervention indicated (e.g., topical agents); limiting instrumental ADL Grade 2 KeratitisPTCTCAE E10398 Grade 2 Keratitis Grade 2 Kidney anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Kidney anastomotic leakPTCTCAE E11881 Grade 2 Kidney anastomotic leak Grade 2 Kyphosis NCIModerate accentuation; limiting instrumental ADL Grade 2 KyphosisPTCTCAE E12449 Grade 2 Kyphosis Grade 2 Lactation disorder NCIChanges in lactation, significantly affecting breast production or expression of breast milk Grade 2 Lactation disorderPTCTCAE E13131 Grade 2 Lactation disorder Grade 2 Large intestinal anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Large intestinal anastomotic leakPTCTCAE E11887 Grade 2 Large intestinal anastomotic leak Grade 2 Laryngeal edema NCISymptomatic; medical intervention indicated (e.g., dexamethasone, epinephrine, antihistamines) Grade 2 Laryngeal edemaPTCTCAE E13395 Grade 2 Laryngeal edema Grade 2 Laryngeal fistula NCISymptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL Grade 2 Laryngeal fistulaPTCTCAE E13401 Grade 2 Laryngeal fistula Grade 2 Laryngeal hemorrhage NCIModerate symptoms; medical intervention indicated Grade 2 Laryngeal hemorrhagePTCTCAE E13407 Grade 2 Laryngeal hemorrhage Grade 2 Laryngeal inflammation NCIModerate sore throat; analgesics indicated Grade 2 Laryngeal inflammationPTCTCAE E13413 Grade 2 Laryngeal inflammation Grade 2 Laryngeal mucositis NCIModerate discomfort; altered oral intake Grade 2 Laryngeal mucositisPTCTCAE E13417 Grade 2 Laryngeal mucositis Grade 2 Laryngeal obstruction NCISymptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids); limiting instrumental ADL Grade 2 Laryngeal obstructionPTCTCAE E13423 Grade 2 Laryngeal obstruction Grade 2 Laryngeal stenosis NCISymptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids) Grade 2 Laryngeal stenosisPTCTCAE E13429 Grade 2 Laryngeal stenosis Grade 2 Laryngitis NCIModerate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 LaryngitisPTCTCAE E11436 Grade 2 Laryngitis Grade 2 Laryngopharyngeal dysesthesia NCIModerate symptoms; mild anxiety, but no dyspnea; short duration of observation and or anxiolytic indicated; limiting instrumental ADL Grade 2 Laryngopharyngeal dysesthesiaPTCTCAE E13435 Grade 2 Laryngopharyngeal dysesthesia Grade 2 Laryngospasm NCITransient episode; intervention not indicated Grade 2 LaryngospasmPTCTCAE E13440 Grade 2 Laryngospasm Grade 2 Lethargy NCIModerate symptoms; limiting instrumental ADL Grade 2 LethargyPTCTCAE E12711 Grade 2 Lethargy Grade 2 Leukoencephalopathy NCIModerate symptoms; focal T2/FLAIR hyperintensities, involving periventricular white matter extending into centrum semiovale or involving 1/3 to 2/3 of susceptible areas of cerebrum +/- moderate increase in SAS and/or moderate ventriculomegaly Grade 2 LeukoencephalopathyPTCTCAE E12714 Grade 2 Leukoencephalopathy Grade 2 Libido decreased NCIDecrease in sexual interest adversely affecting relationship Grade 2 Libido decreasedPTCTCAE E12931 Grade 2 Libido decreased Grade 2 Libido increased NCIModerate increase in sexual interest adversely affecting relationship Grade 2 Libido increasedPTCTCAE E12934 Grade 2 Libido increased Grade 2 Lip infection NCIOral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Lip infectionPTCTCAE E11442 Grade 2 Lip infection Grade 2 Lip pain NCIModerate pain; limiting instrumental ADL Grade 2 Lip painPTCTCAE E10859 Grade 2 Lip pain Grade 2 Lipase increased NCI>1.5 - 2.0 x ULN Grade 2 Lipase increasedPTCTCAE E12187 Grade 2 Lipase increased Grade 2 Lipohypertrophy NCICovering 10 - 30% BSA and associated tenderness; limiting instrumental ADL Grade 2 LipohypertrophyPTCTCAE E13659 Grade 2 Lipohypertrophy Grade 2 Localized edema NCIModerate localized edema and intervention indicated; limiting instrumental ADL Grade 2 Localized edemaPTCTCAE E11150 Grade 2 Localized edema Grade 2 Lordosis NCIModerate accentuation; limiting instrumental ADL Grade 2 LordosisPTCTCAE E12453 Grade 2 Lordosis Grade 2 Lower gastrointestinal hemorrhage NCIModerate symptoms; medical intervention or minor cauterization indicated Grade 2 Lower gastrointestinal hemorrhagePTCTCAE E10863 Grade 2 Lower gastrointestinal hemorrhage Grade 2 Lung infection NCIModerate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Lung infectionPTCTCAE E11445 Grade 2 Lung infection Grade 2 Lymph gland infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Lymph gland infectionPTCTCAE E11450 Grade 2 Lymph gland infection Grade 2 Lymph leakage NCISymptomatic; medical intervention indicated Grade 2 Lymph leakagePTCTCAE E13798 Grade 2 Lymph leakage Grade 2 Lymph node pain NCIModerate pain; limiting instrumental ADL Grade 2 Lymph node painPTCTCAE E10054 Grade 2 Lymph node pain Grade 2 Lymphedema NCIMarked discoloration; leathery skin texture; papillary formation; limiting instrumental ADL Grade 2 LymphedemaPTCTCAE E13804 Grade 2 Lymphedema Grade 2 Lymphocele NCISymptomatic; medical intervention indicated Grade 2 LymphocelePTCTCAE E13808 Grade 2 Lymphocele Grade 2 Lymphocyte count decreased NCI<800 - 500/mm3; <0.8 - 0.5 x 10e9 /L Grade 2 Lymphocyte count decreasedPTCTCAE E12192 Grade 2 Lymphocyte count decreased Grade 2 Lymphocyte count increased NCI>4000/mm3 - 20,000/mm3 Grade 2 Lymphocyte count increasedPTCTCAE E12196 Grade 2 Lymphocyte count increased Grade 2 Malabsorption NCIAltered diet; oral intervention indicated Grade 2 MalabsorptionPTCTCAE E10868 Grade 2 Malabsorption Grade 2 Malaise NCIUneasiness or lack of well being; limiting instrumental ADL Grade 2 MalaisePTCTCAE E11154 Grade 2 Malaise Grade 2 Mania NCIModerate manic symptoms (e.g., relationship and work difficulties; poor hygiene) Grade 2 ManiaPTCTCAE E12938 Grade 2 Mania Grade 2 Mediastinal hemorrhage NCIModerate symptoms; medical intervention indicated Grade 2 Mediastinal hemorrhagePTCTCAE E13446 Grade 2 Mediastinal hemorrhage Grade 2 Memory impairment NCIModerate memory impairment; limiting instrumental ADL Grade 2 Memory impairmentPTCTCAE E12720 Grade 2 Memory impairment Grade 2 Meningismus NCIModerate symptoms; limiting instrumental ADL Grade 2 MeningismusPTCTCAE E12724 Grade 2 Meningismus Grade 2 Menopause NCIMenopause occurring at age 40 - 45 years of age Grade 2 MenopausePTCTCAE E13752 Grade 2 Menopause Grade 2 Menorrhagia NCIModerate symptoms; medical intervention indicated (e.g., hormones) Grade 2 MenorrhagiaPTCTCAE E13134 Grade 2 Menorrhagia Grade 2 Metabolism and nutrition disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Metabolism and nutrition disorders - Other, specifyPTCTCAE E12357 Grade 2 Metabolism and nutrition disorders - Other, specify Grade 2 Middle ear inflammation NCISerous otitis, medical intervention indicated Grade 2 Middle ear inflammationPTCTCAE E10283 Grade 2 Middle ear inflammation Grade 2 Mitral valve disease NCIAsymptomatic; moderate regurgitation or stenosis by imaging Grade 2 Mitral valve diseasePTCTCAE E10136 Grade 2 Mitral valve disease Grade 2 Mobitz type I NCISymptomatic; medical intervention indicated Grade 2 Mobitz type IPTCTCAE E10148 Grade 2 Mobitz type I Grade 2 Mobitz (type) II atrioventricular block NCISymptomatic; medical intervention indicated Grade 2 Mobitz (type) II atrioventricular blockPTCTCAE E10142 Grade 2 Mobitz (type) II atrioventricular block Grade 2 Movements involuntary NCIModerate symptoms; limiting instrumental ADL Grade 2 Movements involuntaryPTCTCAE E12730 Grade 2 Movements involuntary Grade 2 Mucosal infection NCIOral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Mucosal infectionPTCTCAE E11464 Grade 2 Mucosal infection Grade 2 Mucositis oral NCIModerate pain; not interfering with oral intake; modified diet indicated Grade 2 Mucositis oralPTCTCAE E10874 Grade 2 Mucositis oral Grade 2 Muscle weakness left-sided NCISymptomatic; evident on physical exam; limiting instrumental ADL Grade 2 Muscle weakness left-sidedPTCTCAE E12457 Grade 2 Muscle weakness left-sided Grade 2 Muscle weakness lower limb NCISymptomatic; evident on physical exam; limiting instrumental ADL Grade 2 Muscle weakness lower limbPTCTCAE E12461 Grade 2 Muscle weakness lower limb Grade 2 Muscle weakness right-sided NCISymptomatic; evident on physical exam; limiting instrumental ADL Grade 2 Muscle weakness right-sidedPTCTCAE E12465 Grade 2 Muscle weakness right-sided Grade 2 Muscle weakness trunk NCISymptomatic; evident on physical exam; limiting instrumental ADL Grade 2 Muscle weakness trunkPTCTCAE E12469 Grade 2 Muscle weakness trunk Grade 2 Muscle weakness upper limb NCISymptomatic; evident on physical exam; limiting instrumental ADL Grade 2 Muscle weakness upper limbPTCTCAE E12473 Grade 2 Muscle weakness upper limb Grade 2 Musculoskeletal and connective tissue disorder - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Musculoskeletal and connective tissue disorder - Other, specifyPTCTCAE E12477 Grade 2 Musculoskeletal and connective tissue disorder - Other, specify Grade 2 Musculoskeletal deformity NCIDeformity, hypoplasia, or asymmetry able to be remediated by prosthesis (e.g., shoe insert) or covered by clothing Grade 2 Musculoskeletal deformityPTCTCAE E12483 Grade 2 Musculoskeletal deformity Grade 2 Myalgia NCIModerate pain; limiting instrumental ADL Grade 2 MyalgiaPTCTCAE E12487 Grade 2 Myalgia Grade 2 Myelitis NCIModerate weakness or sensory loss; limiting instrumental ADL Grade 2 MyelitisPTCTCAE E12734 Grade 2 Myelitis Grade 2 Myocardial infarction NCIAsymptomatic and cardiac enzymes minimally abnormal and no evidence of ischemic ECG changes Grade 2 Myocardial infarctionPTCTCAE E10153 Grade 2 Myocardial infarction Grade 2 Myocarditis NCISymptoms with mild to moderate activity or exertion Grade 2 MyocarditisPTCTCAE E10159 Grade 2 Myocarditis Grade 2 Myositis NCIModerate pain associated with weakness; pain limiting instrumental ADL Grade 2 MyositisPTCTCAE E12491 Grade 2 Myositis Grade 2 Nail infection NCIOral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Nail infectionPTCTCAE E11470 Grade 2 Nail infection Grade 2 Nail loss NCISymptomatic separation of the nail bed from the nail plate or nail loss; limiting instrumental ADL Grade 2 Nail lossPTCTCAE E13665 Grade 2 Nail loss Grade 2 Nasal congestion NCIModerate symptoms; medical intervention indicated Grade 2 Nasal congestionPTCTCAE E13452 Grade 2 Nasal congestion Grade 2 Nausea NCIOral intake decreased without significant weight loss, dehydration or malnutrition Grade 2 NauseaPTCTCAE E10880 Grade 2 Nausea Grade 2 Neck edema NCIModerate neck edema; slight obliteration of anatomic landmarks; limiting instrumental ADL Grade 2 Neck edemaPTCTCAE E11161 Grade 2 Neck edema Grade 2 Neck pain NCIModerate pain; limiting instrumental ADL Grade 2 Neck painPTCTCAE E12495 Grade 2 Neck pain Grade 2 Neck soft tissue necrosis NCILocal wound care; medical intervention indicated (e.g., dressings or topical medications) Grade 2 Neck soft tissue necrosisPTCTCAE E12498 Grade 2 Neck soft tissue necrosis Grade 2 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specifyPTCTCAE E12557 Grade 2 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify Grade 2 Nervous system disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Nervous system disorders - Other, specifyPTCTCAE E12740 Grade 2 Nervous system disorders - Other, specify Grade 2 Neuralgia NCIModerate pain; limiting instrumental ADL Grade 2 NeuralgiaPTCTCAE E12746 Grade 2 Neuralgia Grade 2 Neutrophil count decreased NCI<1500 - 1000/mm3; <1.5 - 1.0 x 10e9 /L Grade 2 Neutrophil count decreasedPTCTCAE E12200 Grade 2 Neutrophil count decreased Grade 2 Night blindness NCILimiting instrumental ADL Grade 2 Night blindnessPTCTCAE E10403 Grade 2 Night blindness Grade 2 Nipple deformity NCISymptomatic; asymmetry of nipple areolar complex with moderate retraction and/or thickening of the nipple areolar complex Grade 2 Nipple deformityPTCTCAE E13140 Grade 2 Nipple deformity Grade 2 Non-cardiac chest pain NCIModerate pain; limiting instrumental ADL Grade 2 Non-cardiac chest painPTCTCAE E11165 Grade 2 Non-cardiac chest pain Grade 2 Nystagmus NCIModerate symptoms; limiting instrumental ADL Grade 2 NystagmusPTCTCAE E12749 Grade 2 Nystagmus Grade 2 Obesity NCIBMI 25 - 29.9 kg/m2 Grade 2 ObesityPTCTCAE E12362 Grade 2 Obesity Grade 2 Obstruction gastric NCISymptomatic; altered GI function; limiting instrumental ADL Grade 2 Obstruction gastricPTCTCAE E10884 Grade 2 Obstruction gastric Grade 2 Oculomotor nerve disorder NCIModerate symptoms; limiting instrumental ADL Grade 2 Oculomotor nerve disorderPTCTCAE E12753 Grade 2 Oculomotor nerve disorder Grade 2 Olfactory nerve disorder NCIModerate symptoms; limiting instrumental ADL Grade 2 Olfactory nerve disorderPTCTCAE E12756 Grade 2 Olfactory nerve disorder Grade 2 Oligospermia NCISperm concentration 13 - 48 million/mL or motility 32 - 68% Grade 2 OligospermiaPTCTCAE E13143 Grade 2 Oligospermia Grade 2 Optic nerve disorder NCILimiting vision of the affected eye (20/40 or better) Grade 2 Optic nerve disorderPTCTCAE E10408 Grade 2 Optic nerve disorder Grade 2 Oral cavity fistula NCISymptomatic; altered GI function Grade 2 Oral cavity fistulaPTCTCAE E10890 Grade 2 Oral cavity fistula Grade 2 Oral dysesthesia NCIModerate pain; interfering with oral intake Grade 2 Oral dysesthesiaPTCTCAE E10896 Grade 2 Oral dysesthesia Grade 2 Oral hemorrhage NCIModerate symptoms; medical intervention or minor cauterization indicated Grade 2 Oral hemorrhagePTCTCAE E10900 Grade 2 Oral hemorrhage Grade 2 Oral pain NCIModerate pain; limiting instrumental ADL Grade 2 Oral painPTCTCAE E10906 Grade 2 Oral pain Grade 2 Osteonecrosis of jaw NCISymptomatic; medical intervention indicated (e.g., topical agents); limiting instrumental ADL Grade 2 Osteonecrosis of jawPTCTCAE E12504 Grade 2 Osteonecrosis of jaw Grade 2 Osteoporosis NCIBMD t-score <-2.5; loss of height <2 cm; anti-osteoporotic therapy indicated; limiting instrumental ADL Grade 2 OsteoporosisPTCTCAE E12510 Grade 2 Osteoporosis Grade 2 Otitis externa NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Otitis externaPTCTCAE E11473 Grade 2 Otitis externa Grade 2 Otitis media NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Otitis mediaPTCTCAE E11478 Grade 2 Otitis media Grade 2 Ovarian hemorrhage NCIModerate bleeding; medical intervention indicated Grade 2 Ovarian hemorrhagePTCTCAE E13147 Grade 2 Ovarian hemorrhage Grade 2 Ovarian infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Ovarian infectionPTCTCAE E11483 Grade 2 Ovarian infection Grade 2 Ovarian rupture NCISymptomatic and intervention not indicated Grade 2 Ovarian rupturePTCTCAE E13153 Grade 2 Ovarian rupture Grade 2 Ovulation pain NCIModerate pain; limiting instrumental ADL Grade 2 Ovulation painPTCTCAE E13159 Grade 2 Ovulation pain Grade 2 Pain NCIModerate pain; limiting instrumental ADL Grade 2 PainPTCTCAE E11169 Grade 2 Pain Grade 2 Pain in extremity NCIModerate pain; limiting instrumental ADL Grade 2 Pain in extremityPTCTCAE E12514 Grade 2 Pain in extremity Grade 2 Pain of skin NCIModerate pain; limiting instrumental ADL Grade 2 Pain of skinPTCTCAE E13670 Grade 2 Pain of skin Grade 2 Palmar-plantar erythrodysesthesia syndrome NCISkin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting instrumental ADL Grade 2 Palmar-plantar erythrodysesthesia syndromePTCTCAE E13674 Grade 2 Palmar-plantar erythrodysesthesia syndrome Grade 2 Palpitations NCIIntervention indicated Grade 2 PalpitationsPTCTCAE E10165 Grade 2 Palpitations Grade 2 Pancreatic anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Pancreatic anastomotic leakPTCTCAE E11893 Grade 2 Pancreatic anastomotic leak Grade 2 Pancreatic duct stenosis NCISymptomatic; altered GI function Grade 2 Pancreatic duct stenosisPTCTCAE E10910 Grade 2 Pancreatic duct stenosis Grade 2 Pancreatic enzymes decreased NCIIncrease in stool frequency, bulk, or odor; steatorrhea Grade 2 Pancreatic enzymes decreasedPTCTCAE E12205 Grade 2 Pancreatic enzymes decreased Grade 2 Pancreatic fistula NCISymptomatic; altered GI function Grade 2 Pancreatic fistulaPTCTCAE E10916 Grade 2 Pancreatic fistula Grade 2 Pancreatic hemorrhage NCIModerate symptoms; medical intervention or minor cauterization indicated Grade 2 Pancreatic hemorrhagePTCTCAE E10922 Grade 2 Pancreatic hemorrhage Grade 2 Pancreatitis NCIEnzyme elevation or radiologic findings only Grade 2 PancreatitisPTCTCAE E10931 Grade 2 Pancreatitis Grade 2 Papilledema NCISymptomatic decline in vision; visual field defect present sparing the central 20 degrees Grade 2 PapilledemaPTCTCAE E10413 Grade 2 Papilledema Grade 2 Papulopustular rash NCIPapules and/or pustules covering 10-30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL Grade 2 Papulopustular rashPTCTCAE E11493 Grade 2 Papulopustular rash Grade 2 Paresthesia NCIModerate symptoms; limiting instrumental ADL Grade 2 ParesthesiaPTCTCAE E12760 Grade 2 Paresthesia Grade 2 Paronychia NCILocalized intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral); nail fold edema or erythema with pain; associated with discharge or nail plate separation; limiting instrumental ADL Grade 2 ParonychiaPTCTCAE E11499 Grade 2 Paronychia Grade 2 Paroxysmal atrial tachycardia NCISymptomatic; medical management indicated Grade 2 Paroxysmal atrial tachycardiaPTCTCAE E10168 Grade 2 Paroxysmal atrial tachycardia Grade 2 Pelvic floor muscle weakness NCISymptomatic, not interfering with bladder, bowel, or vaginal function; limiting instrumental ADL Grade 2 Pelvic floor muscle weaknessPTCTCAE E13163 Grade 2 Pelvic floor muscle weakness Grade 2 Pelvic infection NCIModerate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Pelvic infectionPTCTCAE E11502 Grade 2 Pelvic infection Grade 2 Pelvic pain NCIModerate pain; limiting instrumental ADL Grade 2 Pelvic painPTCTCAE E13169 Grade 2 Pelvic pain Grade 2 Pelvic soft tissue necrosis NCILocal wound care; medical intervention indicated (e.g., dressings or topical medications) Grade 2 Pelvic soft tissue necrosisPTCTCAE E12517 Grade 2 Pelvic soft tissue necrosis Grade 2 Penile infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Penile infectionPTCTCAE E11507 Grade 2 Penile infection Grade 2 Penile pain NCIModerate pain; limiting instrumental ADL Grade 2 Penile painPTCTCAE E13173 Grade 2 Penile pain Grade 2 Pericardial effusion NCIAsymptomatic effusion size small to moderate Grade 2 Pericardial effusionPTCTCAE E10173 Grade 2 Pericardial effusion Grade 2 Pericarditis NCISymptomatic pericarditis (e.g., chest pain) Grade 2 PericarditisPTCTCAE E10182 Grade 2 Pericarditis Grade 2 Perineal pain NCIModerate pain; limiting instrumental ADL Grade 2 Perineal painPTCTCAE E13177 Grade 2 Perineal pain Grade 2 Periodontal disease NCIModerate gingival recession or gingivitis; multiple sites of bleeding on probing; moderate bone loss Grade 2 Periodontal diseasePTCTCAE E10937 Grade 2 Periodontal disease Grade 2 Periorbital edema NCIIndurated or pitting edema; topical intervention indicated Grade 2 Periorbital edemaPTCTCAE E13678 Grade 2 Periorbital edema Grade 2 Periorbital infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Periorbital infectionPTCTCAE E11512 Grade 2 Periorbital infection Grade 2 Peripheral ischemia NCIBrief (<24 hrs) episode of ischemia managed non-surgically and without permanent deficit Grade 2 Peripheral ischemiaPTCTCAE E13811 Grade 2 Peripheral ischemia Grade 2 Peripheral motor neuropathy NCIModerate symptoms; limiting instrumental ADL Grade 2 Peripheral motor neuropathyPTCTCAE E12764 Grade 2 Peripheral motor neuropathy Grade 2 Peripheral nerve infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Peripheral nerve infectionPTCTCAE E11517 Grade 2 Peripheral nerve infection Grade 2 Peripheral sensory neuropathy NCIModerate symptoms; limiting instrumental ADL Grade 2 Peripheral sensory neuropathyPTCTCAE E12770 Grade 2 Peripheral sensory neuropathy Grade 2 Personality change NCIModerate personality change Grade 2 Personality changePTCTCAE E12944 Grade 2 Personality change Grade 2 Phantom pain NCIModerate pain; limiting instrumental ADL Grade 2 Phantom painPTCTCAE E12776 Grade 2 Phantom pain Grade 2 Pharyngeal anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Pharyngeal anastomotic leakPTCTCAE E11899 Grade 2 Pharyngeal anastomotic leak Grade 2 Pharyngeal fistula NCISymptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL Grade 2 Pharyngeal fistulaPTCTCAE E13456 Grade 2 Pharyngeal fistula Grade 2 Pharyngeal hemorrhage NCIModerate symptoms; medical intervention indicated Grade 2 Pharyngeal hemorrhagePTCTCAE E13462 Grade 2 Pharyngeal hemorrhage Grade 2 Pharyngeal mucositis NCIModerate pain and analgesics indicated; altered oral intake; limiting instrumental ADL Grade 2 Pharyngeal mucositisPTCTCAE E13468 Grade 2 Pharyngeal mucositis Grade 2 Pharyngeal stenosis NCISymptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids); limiting instrumental ADL Grade 2 Pharyngeal stenosisPTCTCAE E13478 Grade 2 Pharyngeal stenosis Grade 2 Pharyngitis NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 PharyngitisPTCTCAE E11526 Grade 2 Pharyngitis Grade 2 Pharyngolaryngeal pain NCIModerate pain; limiting instrumental ADL Grade 2 Pharyngolaryngeal painPTCTCAE E13484 Grade 2 Pharyngolaryngeal pain Grade 2 Phlebitis NCIPresent Grade 2 PhlebitisPTCTCAE E13816 Grade 2 Phlebitis Grade 2 Phlebitis infective NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Phlebitis infectivePTCTCAE E11531 Grade 2 Phlebitis infective Grade 2 Photophobia NCILimiting instrumental ADL Grade 2 PhotophobiaPTCTCAE E10418 Grade 2 Photophobia Grade 2 Photosensitivity NCITender erythema covering 10 - 30% BSA Grade 2 PhotosensitivityPTCTCAE E13682 Grade 2 Photosensitivity Grade 2 Platelet count decreased NCI<75,000 - 50,000/mm3; <75.0 - 50.0 x 10e9 /L Grade 2 Platelet count decreasedPTCTCAE E12209 Grade 2 Platelet count decreased Grade 2 Pleural effusion NCISymptomatic; intervention indicated (e.g., diuretics or limited therapeutic thoracentesis) Grade 2 Pleural effusionPTCTCAE E13488 Grade 2 Pleural effusion Grade 2 Pleural hemorrhage NCISymptomatic or associated with pneumothorax; chest tube drainage indicated Grade 2 Pleural hemorrhagePTCTCAE E13494 Grade 2 Pleural hemorrhage Grade 2 Pleural infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Pleural infectionPTCTCAE E11536 Grade 2 Pleural infection Grade 2 Pleuritic pain NCIModerate pain; limiting instrumental ADL Grade 2 Pleuritic painPTCTCAE E13500 Grade 2 Pleuritic pain Grade 2 Pneumonitis NCISymptomatic; medical intervention indicated; limiting instrumental ADL Grade 2 PneumonitisPTCTCAE E13504 Grade 2 Pneumonitis Grade 2 Pneumothorax NCISymptomatic; intervention indicated (e.g., tube placement without sclerosis) Grade 2 PneumothoraxPTCTCAE E13510 Grade 2 Pneumothorax Grade 2 Portal hypertension NCIDecreased portal vein flow Grade 2 Portal hypertensionPTCTCAE E11239 Grade 2 Portal hypertension Grade 2 Portal vein thrombosis NCIIntervention not indicated Grade 2 Portal vein thrombosisPTCTCAE E11244 Grade 2 Portal vein thrombosis Grade 2 Postnasal drip NCIModerate symptoms; medical intervention indicated Grade 2 Postnasal dripPTCTCAE E13516 Grade 2 Postnasal drip Grade 2 Postoperative hemorrhage NCIModerate bleeding; radiologic, endoscopic, or operative intervention indicated Grade 2 Postoperative hemorrhagePTCTCAE E11905 Grade 2 Postoperative hemorrhage Grade 2 Postoperative thoracic procedure complication NCIExtubated within 24 - 72 hrs postoperatively Grade 2 Postoperative thoracic procedure complicationPTCTCAE E11910 Grade 2 Postoperative thoracic procedure complication Grade 2 Precocious puberty NCIPhysical signs and biochemical markers of puberty for females <8 years and males <9 years Grade 2 Precocious pubertyPTCTCAE E10342 Grade 2 Precocious puberty Grade 2 Pregnancy, puerperium and perinatal conditions - Other, specify NCIModerate, local or noninvasive intervention indicated; limiting instrumental ADL Grade 2 Pregnancy, puerperium and perinatal conditions - Other, specifyPTCTCAE E12863 Grade 2 Pregnancy, puerperium and perinatal conditions - Other, specify Grade 2 Premature delivery NCIDelivery of a liveborn infant at >28 to 34 weeks gestation Grade 2 Premature deliveryPTCTCAE E12869 Grade 2 Premature delivery Grade 2 Presyncope NCIPresent (e.g., near fainting) Grade 2 PresyncopePTCTCAE E12779 Grade 2 Presyncope Grade 2 Proctitis NCISymptoms (e.g., rectal discomfort, passing blood or mucus); medical intervention indicated; limiting instrumental ADL Grade 2 ProctitisPTCTCAE E10945 Grade 2 Proctitis Grade 2 Productive cough NCIModerate sputum production; limiting instrumental ADL Grade 2 Productive coughPTCTCAE E13519 Grade 2 Productive cough Grade 2 Prolapse of intestinal stoma NCIRecurrent after manual reduction; local irritation or stool leakage; difficulty to fit appliance; limiting instrumental ADL Grade 2 Prolapse of intestinal stomaPTCTCAE E11916 Grade 2 Prolapse of intestinal stoma Grade 2 Prolapse of urostomy NCILocal care or maintenance; minor revision indicated Grade 2 Prolapse of urostomyPTCTCAE E11922 Grade 2 Prolapse of urostomy Grade 2 Prostate infection NCIModerate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Prostate infectionPTCTCAE E11541 Grade 2 Prostate infection Grade 2 Prostatic hemorrhage NCIModerate bleeding; medical intervention indicated Grade 2 Prostatic hemorrhagePTCTCAE E13183 Grade 2 Prostatic hemorrhage Grade 2 Prostatic obstruction NCIMild symptoms; elective intervention indicated Grade 2 Prostatic obstructionPTCTCAE E13189 Grade 2 Prostatic obstruction Grade 2 Prostatic pain NCIModerate pain; limiting instrumental ADL Grade 2 Prostatic painPTCTCAE E13193 Grade 2 Prostatic pain Grade 2 Proteinuria NCIAdults: 2+ proteinuria; urinary protein 1.0 - 3.4 g/24 hrs; Pediatric: urine P/C (Protein/Creatinine) ratio 0.5 - 1.9 Grade 2 ProteinuriaPTCTCAE E13010 Grade 2 Proteinuria Grade 2 Pruritus NCIIntense or widespread; intermittent; skin changes from scratching (e.g., edema, papulation, excoriations, lichenification, oozing/crusts); oral intervention indicated; limiting instrumental ADL Grade 2 PruritusPTCTCAE E13688 Grade 2 Pruritus Grade 2 Psychiatric disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Psychiatric disorders - Other, specifyPTCTCAE E12950 Grade 2 Psychiatric disorders - Other, specify Grade 2 Psychosis NCIModerate psychotic symptoms (e.g., disorganized speech; impaired reality testing) Grade 2 PsychosisPTCTCAE E12956 Grade 2 Psychosis Grade 2 Pulmonary edema NCIModerate dyspnea on exertion; medical intervention indicated; limiting instrumental ADL Grade 2 Pulmonary edemaPTCTCAE E13523 Grade 2 Pulmonary edema Grade 2 Pulmonary fibrosis NCIModerate hypoxemia; evidence of pulmonary hypertension; radiographic pulmonary fibrosis 25 - 50% Grade 2 Pulmonary fibrosisPTCTCAE E13529 Grade 2 Pulmonary fibrosis Grade 2 Pulmonary fistula NCISymptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL Grade 2 Pulmonary fistulaPTCTCAE E13535 Grade 2 Pulmonary fistula Grade 2 Pulmonary hypertension NCIModerate dyspnea, cough; requiring evaluation by cardiac catheterization and medical intervention Grade 2 Pulmonary hypertensionPTCTCAE E13541 Grade 2 Pulmonary hypertension Grade 2 Pulmonary valve disease NCIAsymptomatic; moderate regurgitation or stenosis by imaging Grade 2 Pulmonary valve diseasePTCTCAE E10188 Grade 2 Pulmonary valve disease Grade 2 Purpura NCICombined area of lesions covering 10 - 30% BSA; bleeding with trauma Grade 2 PurpuraPTCTCAE E13692 Grade 2 Purpura Grade 2 Pyramidal tract syndrome NCIModerate symptoms; limiting instrumental ADL Grade 2 Pyramidal tract syndromePTCTCAE E12782 Grade 2 Pyramidal tract syndrome Grade 2 Radiation recall reaction (dermatologic) NCIModerate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema Grade 2 Radiation recall reaction (dermatologic)PTCTCAE E11928 Grade 2 Radiation recall reaction (dermatologic) Grade 2 Radiculitis NCIModerate symptoms; limiting instrumental ADL; medical intervention indicated Grade 2 RadiculitisPTCTCAE E12788 Grade 2 Radiculitis Grade 2 Rash acneiform NCIPapules and/or pustules covering 10 - 30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL Grade 2 Rash acneiformPTCTCAE E13696 Grade 2 Rash acneiform Grade 2 Rash maculo-papular NCIMacules/papules covering 10 - 30% BSA with or without symptoms (e.g., pruritus, burning, tightness); limiting instrumental ADL Grade 2 Rash maculo-papularPTCTCAE E13702 Grade 2 Rash maculo-papular Grade 2 Rash pustular NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Rash pustularPTCTCAE E11546 Grade 2 Rash pustular Grade 2 Rectal anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Rectal anastomotic leakPTCTCAE E11934 Grade 2 Rectal anastomotic leak Grade 2 Rectal fistula NCISymptomatic; altered GI function Grade 2 Rectal fistulaPTCTCAE E10951 Grade 2 Rectal fistula Grade 2 Rectal hemorrhage NCIModerate symptoms; medical intervention or minor cauterization indicated Grade 2 Rectal hemorrhagePTCTCAE E10957 Grade 2 Rectal hemorrhage Grade 2 Rectal mucositis NCISymptomatic; medical intervention indicated; limiting instrumental ADL Grade 2 Rectal mucositisPTCTCAE E10963 Grade 2 Rectal mucositis Grade 2 Rectal obstruction NCISymptomatic; altered GI function; limiting instrumental ADL Grade 2 Rectal obstructionPTCTCAE E10973 Grade 2 Rectal obstruction Grade 2 Rectal pain NCIModerate pain; limiting instrumental ADL Grade 2 Rectal painPTCTCAE E10979 Grade 2 Rectal pain Grade 2 Rectal perforation NCISymptomatic; medical intervention indicated Grade 2 Rectal perforationPTCTCAE E10982 Grade 2 Rectal perforation Grade 2 Rectal stenosis NCISymptomatic; altered GI function Grade 2 Rectal stenosisPTCTCAE E10988 Grade 2 Rectal stenosis Grade 2 Rectal ulcer NCISymptomatic; altered GI function (e.g. altered dietary habits, vomiting, diarrhea) Grade 2 Rectal ulcerPTCTCAE E10994 Grade 2 Rectal ulcer Grade 2 Recurrent laryngeal nerve palsy NCIModerate symptoms Grade 2 Recurrent laryngeal nerve palsyPTCTCAE E12794 Grade 2 Recurrent laryngeal nerve palsy Grade 2 Renal and urinary disorders - Other, specify NCIModerate, local or noninvasive intervention indicated; limiting instrumental ADL Grade 2 Renal and urinary disorders - Other, specifyPTCTCAE E13014 Grade 2 Renal and urinary disorders - Other, specify Grade 2 Renal calculi NCISymptomatic; oral antiemetics indicated; around the clock nonprescription analgesics or any oral narcotic analgesics indicated Grade 2 Renal calculiPTCTCAE E13020 Grade 2 Renal calculi Grade 2 Renal colic NCIModerate pain; limiting instrumental ADL; prescription medication indicated Grade 2 Renal colicPTCTCAE E13026 Grade 2 Renal colic Grade 2 Renal hemorrhage NCIAnalgesics and hematocrit monitoring indicated Grade 2 Renal hemorrhagePTCTCAE E13030 Grade 2 Renal hemorrhage Grade 2 Reproductive system and breast disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Reproductive system and breast disorders - Other, specifyPTCTCAE E13197 Grade 2 Reproductive system and breast disorders - Other, specify Grade 2 Respiratory, thoracic and mediastinal disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Respiratory, thoracic and mediastinal disorders - Other, specifyPTCTCAE E13550 Grade 2 Respiratory, thoracic and mediastinal disorders - Other, specify Grade 2 Restlessness NCIModerate symptoms; limiting instrumental ADL Grade 2 RestlessnessPTCTCAE E12962 Grade 2 Restlessness Grade 2 Retinal detachment NCIExudative and visual acuity 20/40 or better Grade 2 Retinal detachmentPTCTCAE E10422 Grade 2 Retinal detachment Grade 2 Retinal tear NCILaser therapy or pneumopexy indicated Grade 2 Retinal tearPTCTCAE E10426 Grade 2 Retinal tear Grade 2 Retinal vascular disorder NCITopical medication indicated Grade 2 Retinal vascular disorderPTCTCAE E10430 Grade 2 Retinal vascular disorder Grade 2 Retinoic acid syndrome NCIModerate signs or symptoms; steroids indicated Grade 2 Retinoic acid syndromePTCTCAE E13556 Grade 2 Retinoic acid syndrome Grade 2 Retinopathy NCISymptomatic with moderate decrease in visual acuity (20/40 or better); limiting instrumental ADL Grade 2 RetinopathyPTCTCAE E10434 Grade 2 Retinopathy Grade 2 Retroperitoneal hemorrhage NCISelf-limited; intervention indicated Grade 2 Retroperitoneal hemorrhagePTCTCAE E10999 Grade 2 Retroperitoneal hemorrhage Grade 2 Reversible posterior leukoencephalopathy syndrome NCIModerate symptoms; abnormal imaging studies; limiting instrumental ADL Grade 2 Reversible posterior leukoencephalopathy syndromePTCTCAE E12800 Grade 2 Reversible posterior leukoencephalopathy syndrome Grade 2 Rhinitis infective NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Rhinitis infectivePTCTCAE E11549 Grade 2 Rhinitis infective Grade 2 Right ventricular dysfunction NCISymptoms with mild to moderate activity or exertion Grade 2 Right ventricular dysfunctionPTCTCAE E10198 Grade 2 Right ventricular dysfunction Grade 2 Salivary duct inflammation NCIThick, ropy, sticky saliva; markedly altered taste; alteration in diet indicated; secretion-induced symptoms; limiting instrumental ADL Grade 2 Salivary duct inflammationPTCTCAE E11005 Grade 2 Salivary duct inflammation Grade 2 Salivary gland fistula NCISymptomatic; altered GI function; tube feeding indicated Grade 2 Salivary gland fistulaPTCTCAE E11011 Grade 2 Salivary gland fistula Grade 2 Salivary gland infection NCIModerate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Salivary gland infectionPTCTCAE E11551 Grade 2 Salivary gland infection Grade 2 Scalp pain NCIModerate pain; limiting instrumental ADL Grade 2 Scalp painPTCTCAE E13706 Grade 2 Scalp pain Grade 2 Scleral disorder NCISymptomatic, limiting instrumental ADL; moderate decrease in visual acuity (20/40 or better) Grade 2 Scleral disorderPTCTCAE E10439 Grade 2 Scleral disorder Grade 2 Scoliosis NCI>20 - 45 degrees; visible by forward flexion; limiting instrumental ADL Grade 2 ScoliosisPTCTCAE E12523 Grade 2 Scoliosis Grade 2 Scrotal infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Scrotal infectionPTCTCAE E11556 Grade 2 Scrotal infection Grade 2 Scrotal pain NCIModerate pain; limiting instrumental ADL Grade 2 Scrotal painPTCTCAE E13203 Grade 2 Scrotal pain Grade 2 Seizure NCIBrief generalized seizure Grade 2 SeizurePTCTCAE E12806 Grade 2 Seizure Grade 2 Seroma NCISymptomatic; simple aspiration indicated Grade 2 SeromaPTCTCAE E11940 Grade 2 Seroma Grade 2 Serum amylase increased NCI>1.5 - 2.0 x ULN Grade 2 Serum amylase increasedPTCTCAE E12214 Grade 2 Serum amylase increased Grade 2 Serum sickness NCIModerate arthralgia; fever, rash, urticaria, antihistamines indicated Grade 2 Serum sicknessPTCTCAE E11278 Grade 2 Serum sickness Grade 2 Sick sinus syndrome NCINon-urgent intervention indicated Grade 2 Sick sinus syndromePTCTCAE E10204 Grade 2 Sick sinus syndrome Grade 2 Sinus bradycardia NCISymptomatic, medical intervention indicated Grade 2 Sinus bradycardiaPTCTCAE E10210 Grade 2 Sinus bradycardia Grade 2 Sinus disorder NCISymptomatic stenosis or edema/narrowing interfering with airflow; limiting instrumental ADL Grade 2 Sinus disorderPTCTCAE E13562 Grade 2 Sinus disorder Grade 2 Sinus pain NCIModerate pain; limiting instrumental ADL Grade 2 Sinus painPTCTCAE E12812 Grade 2 Sinus pain Grade 2 Sinus tachycardia NCISymptomatic; non-urgent medical intervention indicated Grade 2 Sinus tachycardiaPTCTCAE E10216 Grade 2 Sinus tachycardia Grade 2 Sinusitis NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 SinusitisPTCTCAE E11564 Grade 2 Sinusitis Grade 2 Skin and subcutaneous tissue disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Skin and subcutaneous tissue disorders - Other, specifyPTCTCAE E13710 Grade 2 Skin and subcutaneous tissue disorders - Other, specify Grade 2 Skin atrophy NCICovering 10 - 30% BSA; associated with striae or adnexal structure loss Grade 2 Skin atrophyPTCTCAE E13716 Grade 2 Skin atrophy Grade 2 Skin hyperpigmentation NCIHyperpigmentation covering >10% BSA; associated psychosocial impact Grade 2 Skin hyperpigmentationPTCTCAE E13720 Grade 2 Skin hyperpigmentation Grade 2 Skin hypopigmentation NCIHypopigmentation or depigmentation covering >10% BSA; associated psychosocial impact Grade 2 Skin hypopigmentationPTCTCAE E13723 Grade 2 Skin hypopigmentation Grade 2 Skin induration NCIModerate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL Grade 2 Skin indurationPTCTCAE E13726 Grade 2 Skin induration Grade 2 Skin infection NCIOral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Skin infectionPTCTCAE E11570 Grade 2 Skin infection Grade 2 Skin ulceration NCICombined area of ulcers 1 - 2 cm; partial thickness skin loss involving skin or subcutaneous fat Grade 2 Skin ulcerationPTCTCAE E13732 Grade 2 Skin ulceration Grade 2 Sleep apnea NCIModerate apnea and oxygen desaturation; excessive daytime sleepiness; medical evaluation indicated; limiting instrumental ADL Grade 2 Sleep apneaPTCTCAE E13568 Grade 2 Sleep apnea Grade 2 Small intestinal anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Small intestinal anastomotic leakPTCTCAE E11944 Grade 2 Small intestinal anastomotic leak Grade 2 Small intestinal mucositis NCISymptomatic; medical intervention indicated; limiting instrumental ADL Grade 2 Small intestinal mucositisPTCTCAE E11017 Grade 2 Small intestinal mucositis Grade 2 Small intestinal obstruction NCISymptomatic; altered GI function; limiting instrumental ADL Grade 2 Small intestinal obstructionPTCTCAE E11023 Grade 2 Small intestinal obstruction Grade 2 Small intestinal perforation NCISymptomatic; medical intervention indicated Grade 2 Small intestinal perforationPTCTCAE E11028 Grade 2 Small intestinal perforation Grade 2 Small intestinal stenosis NCISymptomatic; altered GI function Grade 2 Small intestinal stenosisPTCTCAE E11034 Grade 2 Small intestinal stenosis Grade 2 Small intestine infection NCIModerate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Small intestine infectionPTCTCAE E11575 Grade 2 Small intestine infection Grade 2 Small intestine ulcer NCISymptomatic; altered GI function; limiting instrumental ADL Grade 2 Small intestine ulcerPTCTCAE E11040 Grade 2 Small intestine ulcer Grade 2 Sneezing NCIModerate symptoms; medical intervention indicated Grade 2 SneezingPTCTCAE E13574 Grade 2 Sneezing Grade 2 Social circumstances - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Social circumstances - Other, specifyPTCTCAE E13756 Grade 2 Social circumstances - Other, specify Grade 2 Soft tissue infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Soft tissue infectionPTCTCAE E11580 Grade 2 Soft tissue infection Grade 2 Soft tissue necrosis lower limb NCILocal wound care; medical intervention indicated (e.g., dressings or topical medications) Grade 2 Soft tissue necrosis lower limbPTCTCAE E12526 Grade 2 Soft tissue necrosis lower limb Grade 2 Soft tissue necrosis upper limb NCILocal wound care; medical intervention indicated (e.g., dressings or topical medications) Grade 2 Soft tissue necrosis upper limbPTCTCAE E12531 Grade 2 Soft tissue necrosis upper limb Grade 2 Somnolence NCIModerate sedation; limiting instrumental ADL Grade 2 SomnolencePTCTCAE E12816 Grade 2 Somnolence Grade 2 Sore throat NCIModerate pain; limiting instrumental ADL Grade 2 Sore throatPTCTCAE E13577 Grade 2 Sore throat Grade 2 Spasticity NCIModerate increase in muscle tone and increase in resistance through range of motion Grade 2 SpasticityPTCTCAE E12822 Grade 2 Spasticity Grade 2 Spermatic cord anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Spermatic cord anastomotic leakPTCTCAE E11950 Grade 2 Spermatic cord anastomotic leak Grade 2 Spermatic cord hemorrhage NCIModerate bleeding; medical intervention indicated Grade 2 Spermatic cord hemorrhagePTCTCAE E13207 Grade 2 Spermatic cord hemorrhage Grade 2 Spermatic cord obstruction NCIMild symptoms; elective intervention indicated Grade 2 Spermatic cord obstructionPTCTCAE E13213 Grade 2 Spermatic cord obstruction Grade 2 Spinal fracture NCIModerate back pain; prescription analgesics indicated; limiting instrumental ADL Grade 2 Spinal fracturePTCTCAE E11956 Grade 2 Spinal fracture Grade 2 Spleen disorder NCIProphylactic antibiotics indicated Grade 2 Spleen disorderPTCTCAE E10058 Grade 2 Spleen disorder Grade 2 Stenosis of gastrointestinal stoma NCISymptomatic; IV fluids indicated <24 hrs; manual dilation at bedside Grade 2 Stenosis of gastrointestinal stomaPTCTCAE E11961 Grade 2 Stenosis of gastrointestinal stoma Grade 2 Stoma site infection NCIOral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Stoma site infectionPTCTCAE E11590 Grade 2 Stoma site infection Grade 2 Stomach pain NCIModerate pain; limiting instrumental ADL Grade 2 Stomach painPTCTCAE E11046 Grade 2 Stomach pain Grade 2 Stomal ulcer NCISymptomatic; medical intervention indicated Grade 2 Stomal ulcerPTCTCAE E11967 Grade 2 Stomal ulcer Grade 2 Stroke NCIModerate neurologic deficit Grade 2 StrokePTCTCAE E12828 Grade 2 Stroke Grade 2 Suicidal ideation NCISuicidal ideation with no specific plan or intent Grade 2 Suicidal ideationPTCTCAE E12966 Grade 2 Suicidal ideation Grade 2 Superficial soft tissue fibrosis NCIModerate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL Grade 2 Superficial soft tissue fibrosisPTCTCAE E12537 Grade 2 Superficial soft tissue fibrosis Grade 2 Superficial thrombophlebitis NCIPresent Grade 2 Superficial thrombophlebitisPTCTCAE E13818 Grade 2 Superficial thrombophlebitis Grade 2 Superior vena cava syndrome NCISymptomatic; medical intervention indicated (e.g., anticoagulation, radiation or chemotherapy) Grade 2 Superior vena cava syndromePTCTCAE E13821 Grade 2 Superior vena cava syndrome Grade 2 Supraventricular tachycardia NCINon-urgent medical intervention indicated Grade 2 Supraventricular tachycardiaPTCTCAE E10220 Grade 2 Supraventricular tachycardia Grade 2 Surgical and medical procedures - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Surgical and medical procedures - Other, specifyPTCTCAE E13762 Grade 2 Surgical and medical procedures - Other, specify Grade 2 Telangiectasia NCITelangiectasias covering >10% BSA; associated with psychosocial impact Grade 2 TelangiectasiaPTCTCAE E13742 Grade 2 Telangiectasia Grade 2 Testicular disorder NCISymptomatic but not interfering with urination or sexual activities; intervention not indicated; limiting instrumental ADL Grade 2 Testicular disorderPTCTCAE E13217 Grade 2 Testicular disorder Grade 2 Testicular hemorrhage NCIModerate bleeding; medical intervention indicated Grade 2 Testicular hemorrhagePTCTCAE E13223 Grade 2 Testicular hemorrhage Grade 2 Testicular pain NCIModerate pain; limiting instrumental ADL Grade 2 Testicular painPTCTCAE E13229 Grade 2 Testicular pain Grade 2 Thromboembolic event NCIVenous thrombosis (e.g., uncomplicated deep vein thrombosis), medical intervention indicated Grade 2 Thromboembolic eventPTCTCAE E13827 Grade 2 Thromboembolic event Grade 2 Tinnitus NCIModerate symptoms; limiting instrumental ADL Grade 2 TinnitusPTCTCAE E10289 Grade 2 Tinnitus Grade 2 Tooth development disorder NCIImpairment correctable with oral surgery Grade 2 Tooth development disorderPTCTCAE E11050 Grade 2 Tooth development disorder Grade 2 Tooth infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Tooth infectionPTCTCAE E11595 Grade 2 Tooth infection Grade 2 Toothache NCIModerate pain; limiting instrumental ADL Grade 2 ToothachePTCTCAE E11056 Grade 2 Toothache Grade 2 Tracheal fistula NCISymptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL Grade 2 Tracheal fistulaPTCTCAE E13585 Grade 2 Tracheal fistula Grade 2 Tracheal hemorrhage NCIModerate bleeding; medical intervention indicated Grade 2 Tracheal hemorrhagePTCTCAE E11971 Grade 2 Tracheal hemorrhage Grade 2 Tracheal mucositis NCIModerate symptoms; medical intervention indicated; limiting instrumental ADL Grade 2 Tracheal mucositisPTCTCAE E13591 Grade 2 Tracheal mucositis Grade 2 Tracheal obstruction NCISymptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL Grade 2 Tracheal obstructionPTCTCAE E11977 Grade 2 Tracheal obstruction Grade 2 Tracheal stenosis NCISymptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids) Grade 2 Tracheal stenosisPTCTCAE E13597 Grade 2 Tracheal stenosis Grade 2 Tracheitis NCIModerate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 TracheitisPTCTCAE E11600 Grade 2 Tracheitis Grade 2 Tracheostomy site bleeding NCIModerate bleeding; medical intervention indicated Grade 2 Tracheostomy site bleedingPTCTCAE E11983 Grade 2 Tracheostomy site bleeding Grade 2 Transient ischemic attacks NCIModerate neurologic deficit with or without imaging confirmation Grade 2 Transient ischemic attacksPTCTCAE E12836 Grade 2 Transient ischemic attacks Grade 2 Tremor NCIModerate symptoms; limiting instrumental ADL Grade 2 TremorPTCTCAE E12839 Grade 2 Tremor Grade 2 Tricuspid valve disease NCIAsymptomatic; moderate regurgitation or stenosis by imaging Grade 2 Tricuspid valve diseasePTCTCAE E10226 Grade 2 Tricuspid valve disease Grade 2 Trigeminal nerve disorder NCIModerate symptoms; limiting instrumental ADL Grade 2 Trigeminal nerve disorderPTCTCAE E12843 Grade 2 Trigeminal nerve disorder Grade 2 Trismus NCIDecreased ROM requiring small bites, soft foods or purees Grade 2 TrismusPTCTCAE E12543 Grade 2 Trismus Grade 2 Tumor pain NCIModerate pain; limiting instrumental ADL Grade 2 Tumor painPTCTCAE E12567 Grade 2 Tumor pain Grade 2 Unequal limb length NCIModerate length discrepancy 2 - 5 cm; shoe lift indicated; limiting instrumental ADL Grade 2 Unequal limb lengthPTCTCAE E12547 Grade 2 Unequal limb length Grade 2 Upper gastrointestinal hemorrhage NCIModerate symptoms; medical intervention or minor cauterization indicated Grade 2 Upper gastrointestinal hemorrhagePTCTCAE E11064 Grade 2 Upper gastrointestinal hemorrhage Grade 2 Upper respiratory infection NCIModerate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Upper respiratory infectionPTCTCAE E11605 Grade 2 Upper respiratory infection Grade 2 Ureteric anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Ureteric anastomotic leakPTCTCAE E11989 Grade 2 Ureteric anastomotic leak Grade 2 Urethral anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Urethral anastomotic leakPTCTCAE E11995 Grade 2 Urethral anastomotic leak Grade 2 Urethral infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Urethral infectionPTCTCAE E11610 Grade 2 Urethral infection Grade 2 Urinary fistula NCINoninvasive intervention indicated; urinary or suprapubic catheter placement indicated Grade 2 Urinary fistulaPTCTCAE E13035 Grade 2 Urinary fistula Grade 2 Urinary frequency NCILimiting instrumental ADL; medical management indicated Grade 2 Urinary frequencyPTCTCAE E13041 Grade 2 Urinary frequency Grade 2 Urinary incontinence NCISpontaneous; pads indicated; limiting instrumental ADL Grade 2 Urinary incontinencePTCTCAE E13044 Grade 2 Urinary incontinence Grade 2 Urinary retention NCIPlacement of urinary, suprapubic or intermittent catheter placement indicated; medication indicated Grade 2 Urinary retentionPTCTCAE E13048 Grade 2 Urinary retention Grade 2 Urinary tract infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Urinary tract infectionPTCTCAE E11615 Grade 2 Urinary tract infection Grade 2 Urinary tract obstruction NCISymptomatic but no hydronephrosis, sepsis or renal dysfunction; urethral dilation, urinary or suprapubic catheter indicated Grade 2 Urinary tract obstructionPTCTCAE E13054 Grade 2 Urinary tract obstruction Grade 2 Urinary tract pain NCIModerate pain; limiting instrumental ADL Grade 2 Urinary tract painPTCTCAE E13060 Grade 2 Urinary tract pain Grade 2 Urinary urgency NCILimiting instrumental ADL; medical management indicated Grade 2 Urinary urgencyPTCTCAE E13064 Grade 2 Urinary urgency Grade 2 Urostomy leak NCISymptomatic; medical intervention indicated Grade 2 Urostomy leakPTCTCAE E12001 Grade 2 Urostomy leak Grade 2 Urostomy obstruction NCISymptomatic; dilation or endoscopic repair or stent placement indicated Grade 2 Urostomy obstructionPTCTCAE E12007 Grade 2 Urostomy obstruction Grade 2 Urostomy site bleeding NCIModerate bleeding; medical intervention indicated Grade 2 Urostomy site bleedingPTCTCAE E12013 Grade 2 Urostomy site bleeding Grade 2 Urostomy stenosis NCISymptomatic but no hydronephrosis, no sepsis or no renal dysfunction; dilation or endoscopic repair or stent placement indicated Grade 2 Urostomy stenosisPTCTCAE E12018 Grade 2 Urostomy stenosis Grade 2 Urticaria NCIUrticarial lesions covering 10 - 30% BSA; oral intervention indicated Grade 2 UrticariaPTCTCAE E13748 Grade 2 Urticaria Grade 2 Uterine anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Uterine anastomotic leakPTCTCAE E12024 Grade 2 Uterine anastomotic leak Grade 2 Uterine fistula NCISymptomatic and intervention not indicated Grade 2 Uterine fistulaPTCTCAE E13233 Grade 2 Uterine fistula Grade 2 Uterine hemorrhage NCIModerate bleeding; medical intervention indicated Grade 2 Uterine hemorrhagePTCTCAE E13239 Grade 2 Uterine hemorrhage Grade 2 Uterine infection NCIModerate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Uterine infectionPTCTCAE E11620 Grade 2 Uterine infection Grade 2 Uterine obstruction NCIMild symptoms; elective intervention indicated Grade 2 Uterine obstructionPTCTCAE E13245 Grade 2 Uterine obstruction Grade 2 Uterine pain NCIModerate pain; limiting instrumental ADL Grade 2 Uterine painPTCTCAE E13249 Grade 2 Uterine pain Grade 2 Uterine perforation NCISymptomatic and intervention not indicated Grade 2 Uterine perforationPTCTCAE E12030 Grade 2 Uterine perforation Grade 2 Uveitis NCIAnterior uveitis; medical intervention indicated Grade 2 UveitisPTCTCAE E10444 Grade 2 Uveitis Grade 2 Vaginal anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Vaginal anastomotic leakPTCTCAE E12036 Grade 2 Vaginal anastomotic leak Grade 2 Vaginal discharge NCIModerate to heavy vaginal discharge; use of perineal pad or tampon indicated Grade 2 Vaginal dischargePTCTCAE E13253 Grade 2 Vaginal discharge Grade 2 Vaginal dryness NCIModerate vaginal dryness interfering with sexual function or causing frequent discomfort Grade 2 Vaginal drynessPTCTCAE E13256 Grade 2 Vaginal dryness Grade 2 Vaginal fistula NCISymptomatic and intervention not indicated Grade 2 Vaginal fistulaPTCTCAE E13260 Grade 2 Vaginal fistula Grade 2 Vaginal hemorrhage NCIModerate bleeding; medical intervention indicated Grade 2 Vaginal hemorrhagePTCTCAE E13266 Grade 2 Vaginal hemorrhage Grade 2 Vaginal infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Vaginal infectionPTCTCAE E11625 Grade 2 Vaginal infection Grade 2 Vaginal inflammation NCIModerate discomfort or pain, edema, or redness; limiting instrumental ADL Grade 2 Vaginal inflammationPTCTCAE E13272 Grade 2 Vaginal inflammation Grade 2 Vaginal obstruction NCIMild symptoms; elective intervention indicated Grade 2 Vaginal obstructionPTCTCAE E13278 Grade 2 Vaginal obstruction Grade 2 Vaginal pain NCIModerate pain; limiting instrumental ADL Grade 2 Vaginal painPTCTCAE E13282 Grade 2 Vaginal pain Grade 2 Vaginal perforation NCISymptomatic and intervention not indicated Grade 2 Vaginal perforationPTCTCAE E13286 Grade 2 Vaginal perforation Grade 2 Vaginal stricture NCIVaginal narrowing and/or shortening not interfering with physical examination Grade 2 Vaginal stricturePTCTCAE E13292 Grade 2 Vaginal stricture Grade 2 Vaginismus NCIModerate discomfort or pain associated with vaginal spasm/tightening; disruption in sexual function and physical examination Grade 2 VaginismusPTCTCAE E13297 Grade 2 Vaginismus Grade 2 Vagus nerve disorder NCIModerate symptoms; limiting instrumental ADL Grade 2 Vagus nerve disorderPTCTCAE E12847 Grade 2 Vagus nerve disorder Grade 2 Vas deferens anastomotic leak NCISymptomatic; medical intervention indicated Grade 2 Vas deferens anastomotic leakPTCTCAE E12042 Grade 2 Vas deferens anastomotic leak Grade 2 Vascular access complication NCIDevice dislodgement, blockage, leak, or malposition; device replacement indicated Grade 2 Vascular access complicationPTCTCAE E12047 Grade 2 Vascular access complication Grade 2 Vascular disorders - Other, specify NCIModerate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Grade 2 Vascular disorders - Other, specifyPTCTCAE E13833 Grade 2 Vascular disorders - Other, specify Grade 2 Vasculitis NCIModerate symptoms, medical intervention indicated Grade 2 VasculitisPTCTCAE E13839 Grade 2 Vasculitis Grade 2 Venous injury NCISymptomatic (e.g., claudication); repair or revision not indicated Grade 2 Venous injuryPTCTCAE E12053 Grade 2 Venous injury Grade 2 Ventricular arrhythmia NCINon-urgent medical intervention indicated Grade 2 Ventricular arrhythmiaPTCTCAE E10232 Grade 2 Ventricular arrhythmia Grade 2 Ventricular tachycardia NCINon-urgent medical intervention indicated Grade 2 Ventricular tachycardiaPTCTCAE E10240 Grade 2 Ventricular tachycardia Grade 2 Vertigo NCIModerate symptoms; limiting instrumental ADL Grade 2 VertigoPTCTCAE E10293 Grade 2 Vertigo Grade 2 Vestibular disorder NCISymptomatic; limiting instrumental ADL Grade 2 Vestibular disorderPTCTCAE E10296 Grade 2 Vestibular disorder Grade 2 Virilization NCIModerate symptoms; medical intervention indicated Grade 2 VirilizationPTCTCAE E10345 Grade 2 Virilization Grade 2 Visceral arterial ischemia NCIBrief (<24 hrs) episode of ischemia managed medically and without permanent deficit Grade 2 Visceral arterial ischemiaPTCTCAE E13844 Grade 2 Visceral arterial ischemia Grade 2 Vital capacity abnormal NCI<75 - 50% of predicted value; limiting instrumental ADL Grade 2 Vital capacity abnormalPTCTCAE E12222 Grade 2 Vital capacity abnormal Grade 2 Vitreous hemorrhage NCISymptomatic; limiting instrumental ADL Grade 2 Vitreous hemorrhagePTCTCAE E10449 Grade 2 Vitreous hemorrhage Grade 2 Voice alteration NCIModerate or persistent change from normal voice; still understandable Grade 2 Voice alterationPTCTCAE E13603 Grade 2 Voice alteration Grade 2 Vomiting NCI3 - 5 episodes (separated by 5 minutes) in 24 hrs Grade 2 VomitingPTCTCAE E11070 Grade 2 Vomiting Grade 2 Vulval infection NCIOral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 2 Vulval infectionPTCTCAE E11631 Grade 2 Vulval infection Grade 2 Watering eyes NCIIntervention indicated Grade 2 Watering eyesPTCTCAE E10454 Grade 2 Watering eyes Grade 2 Weight gain NCI10 - <20% from baseline Grade 2 Weight gainPTCTCAE E12226 Grade 2 Weight gain Grade 2 Weight loss NCI10 - <20% from baseline; nutritional support indicated Grade 2 Weight lossPTCTCAE E12230 Grade 2 Weight loss Grade 2 Wheezing NCIModerate symptoms; medical intervention indicated; limiting instrumental ADL Grade 2 WheezingPTCTCAE E13607 Grade 2 Wheezing Grade 2 White blood cell decreased NCI<3000 - 2000/mm3; <3.0 - 2.0 x 10e9 /L Grade 2 White blood cell decreasedPTCTCAE E12234 Grade 2 White blood cell decreased Grade 2 Wolff-Parkinson-White syndrome NCINon-urgent medical intervention indicated Grade 2 Wolff-Parkinson-White syndromePTCTCAE E10246 Grade 2 Wolff-Parkinson-White syndrome Grade 2 Wound complication NCIIncisional separation >25% of wound; local care indicated Grade 2 Wound complicationPTCTCAE E12059 Grade 2 Wound complication Grade 2 Wound dehiscence NCIIncisional separation >25% of wound with local care; asymptomatic hernia or symptomatic hernia without evidence of strangulation Grade 2 Wound dehiscencePTCTCAE E12065 Grade 2 Wound dehiscence Grade 2 Wound infection NCILocalized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 2 Wound infectionPTCTCAE E11636 Grade 2 Wound infection Grade 2 Wrist fracture NCILimiting instrumental ADL; operative intervention indicated Grade 2 Wrist fracturePTCTCAE E12071 Grade 2 Wrist fracture Grade 3 Abdominal distension NCISevere discomfort; limiting self care ADL Grade 3 Abdominal distensionPTCTCAE E10459 Grade 3 Abdominal distension Grade 3 Abdominal infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Abdominal infectionPTCTCAE E11283 Grade 3 Abdominal infection Grade 3 Abdominal pain NCISevere pain; limiting self care ADL Grade 3 Abdominal painPTCTCAE E10463 Grade 3 Abdominal pain Grade 3 Abdominal soft tissue necrosis NCIOperative debridement or other invasive intervention indicated (e.g. tissue reconstruction, flap or grafting) Grade 3 Abdominal soft tissue necrosisPTCTCAE E12371 Grade 3 Abdominal soft tissue necrosis Grade 3 Abducens nerve disorder NCISevere symptoms; limiting self care ADL Grade 3 Abducens nerve disorderPTCTCAE E12572 Grade 3 Abducens nerve disorder Grade 3 Accessory nerve disorder NCISevere symptoms; limiting self care ADL Grade 3 Accessory nerve disorderPTCTCAE E12576 Grade 3 Accessory nerve disorder Grade 3 Acidosis NCIpH <7.3 Grade 3 AcidosisPTCTCAE E12239 Grade 3 Acidosis Grade 3 Acoustic nerve disorder NOS NCISevere symptoms; limiting self care ADL Grade 3 Acoustic nerve disorder NOSPTCTCAE E12580 Grade 3 Acoustic nerve disorder NOS Grade 3 Activated partial thromboplastin time prolonged NCI>2.5 x ULN; hemorrhage Grade 3 Activated partial thromboplastin time prolongedPTCTCAE E12076 Grade 3 Activated partial thromboplastin time prolonged Grade 3 Acute coronary syndrome NCISymptomatic, unstable angina and/or acute myocardial infarction, cardiac enzymes abnormal, hemodynamically stable Grade 3 Acute coronary syndromePTCTCAE E10068 Grade 3 Acute coronary syndrome Grade 3 Acute kidney injury NCICreatinine >3 x baseline or >4.0 mg/dL; hospitalization indicated Grade 3 Acute kidney injuryPTCTCAE E12976 Grade 3 Acute kidney injury Grade 3 Adrenal insufficiency NCISevere symptoms; hospitalization indicated Grade 3 Adrenal insufficiencyPTCTCAE E10301 Grade 3 Adrenal insufficiency Grade 3 Adult respiratory distress syndrome NCIPresent with radiologic findings; intubation not indicated Grade 3 Adult respiratory distress syndromePTCTCAE E13300 Grade 3 Adult respiratory distress syndrome Grade 3 Adverse Event NCIAn adverse event that is medically significant but not life-threatening; or for which inpatient care or prolongation of hospitalization are indicated; or that is an important medical event that does not result in hospitalization, but may jeopardize the patient or may require intervention either to prevent hospitalization, to prevent the AE from becoming life-threatening or causing death; or that is disabling; or that results in persistent or significant disability, incapacity, or limitation of self care activities of daily living (ADLs, getting in and out of bed, dressing, eating, getting around inside, bathing, or using the toilet). Grade 3 Adverse EventPTCTCAE Severe Adverse EventSYCTCAE E10007 Grade 3 Adverse Event Grade 3 Agitation NCISevere agitation; hospitalization not indicated Grade 3 AgitationPTCTCAE E12877 Grade 3 Agitation Grade 3 Akathisia NCISevere restlessness or increased motor activity; limiting self care ADL Grade 3 AkathisiaPTCTCAE E12584 Grade 3 Akathisia Grade 3 Alanine aminotransferase increased NCI>5.0 - 20.0 x ULN Grade 3 Alanine aminotransferase increasedPTCTCAE E12080 Grade 3 Alanine aminotransferase increased Grade 3 Alcohol intolerance NCISevere symptoms; limiting self care ADL Grade 3 Alcohol intolerancePTCTCAE E12244 Grade 3 Alcohol intolerance Grade 3 Alkaline phosphatase increased NCI>5.0 - 20.0 x ULN Grade 3 Alkaline phosphatase increasedPTCTCAE E12085 Grade 3 Alkaline phosphatase increased Grade 3 Alkalosis NCIpH >7.5 Grade 3 AlkalosisPTCTCAE E12249 Grade 3 Alkalosis Grade 3 Allergic reaction NCIProlonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae (e.g., renal impairment, pulmonary infiltrates) Grade 3 Allergic reactionPTCTCAE E11251 Grade 3 Allergic reaction Grade 3 Amnesia NCISevere; long term memory loss; limiting self care ADL Grade 3 AmnesiaPTCTCAE E12588 Grade 3 Amnesia Grade 3 Anal fistula NCISeverely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated Grade 3 Anal fistulaPTCTCAE E10467 Grade 3 Anal fistula Grade 3 Anal hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Anal hemorrhagePTCTCAE E10473 Grade 3 Anal hemorrhage Grade 3 Anal mucositis NCISevere symptoms; limiting self care ADL Grade 3 Anal mucositisPTCTCAE E10479 Grade 3 Anal mucositis Grade 3 Anal necrosis NCITPN or hospitalization indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Anal necrosisPTCTCAE E10483 Grade 3 Anal necrosis Grade 3 Anal pain NCISevere pain; limiting self care ADL Grade 3 Anal painPTCTCAE E10489 Grade 3 Anal pain Grade 3 Anal stenosis NCISymptomatic and severely altered GI function; non-emergent operative intervention indicated; TPN or hospitalization indicated Grade 3 Anal stenosisPTCTCAE E10493 Grade 3 Anal stenosis Grade 3 Anal ulcer NCISeverely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling Grade 3 Anal ulcerPTCTCAE E10499 Grade 3 Anal ulcer Grade 3 Anaphylaxis NCISymptomatic bronchospasm, with or without urticaria; parenteral intervention indicated; allergy-related edema/angioedema; hypotension Grade 3 AnaphylaxisPTCTCAE E11255 Grade 3 Anaphylaxis Grade 3 Anemia NCIHgb <8.0 g/dL; <4.9 mmol/L; <80 g/L; transfusion indicated Grade 3 AnemiaPTCTCAE E10013 Grade 3 Anemia Grade 3 Ankle fracture NCILimiting self care ADL; elective surgery indicated Grade 3 Ankle fracturePTCTCAE E11643 Grade 3 Ankle fracture Grade 3 Anorectal infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Anorectal infectionPTCTCAE E11289 Grade 3 Anorectal infection Grade 3 Anorexia NCIAssociated with significant weight loss or malnutrition (e.g., inadequate oral caloric and/or fluid intake); tube feeding or TPN indicated Grade 3 AnorexiaPTCTCAE E12255 Grade 3 Anorexia Grade 3 Anxiety NCISevere symptoms; limiting self care ADL; hospitalization not indicated Grade 3 AnxietyPTCTCAE E12886 Grade 3 Anxiety Grade 3 Aortic injury NCISevere symptoms; limiting self care ADL; disabling; repair or revision indicated Grade 3 Aortic injuryPTCTCAE E11645 Grade 3 Aortic injury Grade 3 Aortic valve disease NCISymptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention Grade 3 Aortic valve diseasePTCTCAE E10074 Grade 3 Aortic valve disease Grade 3 Aphonia NCIVoicelessness; unable to speak Grade 3 AphoniaPTCTCAE E12590 Grade 3 Aphonia Grade 3 Apnea NCIPresent; medical intervention indicated Grade 3 ApneaPTCTCAE E13307 Grade 3 Apnea Grade 3 Appendicitis NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 AppendicitisPTCTCAE E11293 Grade 3 Appendicitis Grade 3 Appendicitis perforated NCISevere symptoms; elective operative intervention indicated Grade 3 Appendicitis perforatedPTCTCAE E11298 Grade 3 Appendicitis perforated Grade 3 Arachnoiditis NCISevere symptoms; limiting self care ADL Grade 3 ArachnoiditisPTCTCAE E12594 Grade 3 Arachnoiditis Grade 3 Arterial injury NCISevere symptoms; limiting self care ADL; disabling; repair or revision indicated Grade 3 Arterial injuryPTCTCAE E11651 Grade 3 Arterial injury Grade 3 Arteritis infective NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Arteritis infectivePTCTCAE E11302 Grade 3 Arteritis infective Grade 3 Arthralgia NCISevere pain; limiting self care ADL Grade 3 ArthralgiaPTCTCAE E12377 Grade 3 Arthralgia Grade 3 Arthritis NCISevere pain associated with signs of inflammation, erythema, or joint swelling; irreversible joint damage; disabling; limiting self care ADL Grade 3 ArthritisPTCTCAE E12381 Grade 3 Arthritis Grade 3 Ascites NCISevere symptoms; invasive intervention indicated Grade 3 AscitesPTCTCAE E10505 Grade 3 Ascites Grade 3 Aspartate aminotransferase increased NCI>5.0 - 20.0 x ULN Grade 3 Aspartate aminotransferase increasedPTCTCAE E12090 Grade 3 Aspartate aminotransferase increased Grade 3 Aspiration NCIDyspnea and pneumonia symptoms (e.g., aspiration pneumonia); hospitalization indicated; unable to aliment orally Grade 3 AspirationPTCTCAE E13313 Grade 3 Aspiration Grade 3 Ataxia NCISevere symptoms; limiting self care ADL; mechanical assistance indicated Grade 3 AtaxiaPTCTCAE E12600 Grade 3 Ataxia Grade 3 Atelectasis NCIOxygen indicated; hospitalization or elective operative intervention indicated (e.g., stent, laser) Grade 3 AtelectasisPTCTCAE E13319 Grade 3 Atelectasis Grade 3 Atrial fibrillation NCISymptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker), or ablation Grade 3 Atrial fibrillationPTCTCAE E10084 Grade 3 Atrial fibrillation Grade 3 Atrial flutter NCISymptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker), or ablation Grade 3 Atrial flutterPTCTCAE E10090 Grade 3 Atrial flutter Grade 3 Atrioventricular block complete NCISymptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) Grade 3 Atrioventricular block completePTCTCAE E10095 Grade 3 Atrioventricular block complete Grade 3 Autoimmune disorder NCIAutoimmune reactions involving major organ (e.g., colitis, anemia, myocarditis, kidney) Grade 3 Autoimmune disorderPTCTCAE E11261 Grade 3 Autoimmune disorder Grade 3 Avascular necrosis NCISevere symptoms; limiting self care ADL; elective operative intervention indicated Grade 3 Avascular necrosisPTCTCAE E12385 Grade 3 Avascular necrosis Grade 3 Azoospermia NCIAbsence of sperm in ejaculate Grade 3 AzoospermiaPTCTCAE E13068 Grade 3 Azoospermia Grade 3 Back pain NCISevere pain; limiting self care ADL Grade 3 Back painPTCTCAE E12391 Grade 3 Back pain Grade 3 Bile duct stenosis NCISeverely altered GI function; radiologic, endoscopic or elective operative intervention indicated Grade 3 Bile duct stenosisPTCTCAE E11176 Grade 3 Bile duct stenosis Grade 3 Biliary anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Biliary anastomotic leakPTCTCAE E11657 Grade 3 Biliary anastomotic leak Grade 3 Biliary fistula NCISeverely altered GI function; TPN indicated; endoscopic intervention indicated; elective operative intervention indicated Grade 3 Biliary fistulaPTCTCAE E11181 Grade 3 Biliary fistula Grade 3 Biliary tract infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Biliary tract infectionPTCTCAE E11306 Grade 3 Biliary tract infection Grade 3 Bladder anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Bladder anastomotic leakPTCTCAE E11663 Grade 3 Bladder anastomotic leak Grade 3 Bladder infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Bladder infectionPTCTCAE E11311 Grade 3 Bladder infection Grade 3 Bladder perforation NCIIntraperitoneal perforation; elective radiologic, endoscopic or operative intervention indicated Grade 3 Bladder perforationPTCTCAE E12981 Grade 3 Bladder perforation Grade 3 Bladder spasm NCIHospitalization indicated Grade 3 Bladder spasmPTCTCAE E12987 Grade 3 Bladder spasm Grade 3 Blood and lymphatic system disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Blood and lymphatic system disorders - Other, specifyPTCTCAE E10019 Grade 3 Blood and lymphatic system disorders - Other, specify Grade 3 Blood antidiuretic hormone abnormal NCIHospitalization indicated Grade 3 Blood antidiuretic hormone abnormalPTCTCAE E12095 Grade 3 Blood antidiuretic hormone abnormal Grade 3 Blood bilirubin increased NCI>3.0 - 10.0 x ULN Grade 3 Blood bilirubin increasedPTCTCAE E12099 Grade 3 Blood bilirubin increased Grade 3 Blood corticotrophin decreased NCIHospitalization indicated Grade 3 Blood corticotrophin decreasedPTCTCAE E12104 Grade 3 Blood corticotrophin decreased Grade 3 Blood gonadotrophin abnormal NCISevere symptoms; limiting self care ADL Grade 3 Blood gonadotrophin abnormalPTCTCAE E12108 Grade 3 Blood gonadotrophin abnormal Grade 3 Blurred vision NCILimiting self care ADL Grade 3 Blurred visionPTCTCAE E10349 Grade 3 Blurred vision Grade 3 Bone infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Bone infectionPTCTCAE E11315 Grade 3 Bone infection Grade 3 Bone marrow hypocellular NCISeverely hypocellular or >50 - <=75% reduction cellularity from normal for age Grade 3 Bone marrow hypocellularPTCTCAE E10025 Grade 3 Bone marrow hypocellular Grade 3 Bone pain NCISevere pain; limiting self care ADL Grade 3 Bone painPTCTCAE E12395 Grade 3 Bone pain Grade 3 Brachial plexopathy NCISevere symptoms; limiting self care ADL Grade 3 Brachial plexopathyPTCTCAE E12604 Grade 3 Brachial plexopathy Grade 3 Breast atrophy NCIAsymmetry >1/3 of breast volume; severe atrophy Grade 3 Breast atrophyPTCTCAE E13072 Grade 3 Breast atrophy Grade 3 Breast infection NCISevere infection; axillary adenitis; IV antibacterial, antifungal, or antiviral intervention indicated Grade 3 Breast infectionPTCTCAE E11320 Grade 3 Breast infection Grade 3 Breast pain NCISevere pain; limiting self care ADL Grade 3 Breast painPTCTCAE E13076 Grade 3 Breast pain Grade 3 Bronchial fistula NCISevere symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) Grade 3 Bronchial fistulaPTCTCAE E13325 Grade 3 Bronchial fistula Grade 3 Bronchial infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Bronchial infectionPTCTCAE E11325 Grade 3 Bronchial infection Grade 3 Bronchial obstruction NCIShortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement) Grade 3 Bronchial obstructionPTCTCAE E13331 Grade 3 Bronchial obstruction Grade 3 Bronchial stricture NCIShortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement) Grade 3 Bronchial stricturePTCTCAE E13337 Grade 3 Bronchial stricture Grade 3 Bronchopleural fistula NCISevere symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) Grade 3 Bronchopleural fistulaPTCTCAE E13343 Grade 3 Bronchopleural fistula Grade 3 Bronchopulmonary hemorrhage NCITransfusion, radiologic, endoscopic, or operative intervention indicated (e.g., hemostasis of bleeding site) Grade 3 Bronchopulmonary hemorrhagePTCTCAE E13349 Grade 3 Bronchopulmonary hemorrhage Grade 3 Bronchospasm NCILimiting self care ADL; oxygen saturation decreased Grade 3 BronchospasmPTCTCAE E13355 Grade 3 Bronchospasm Grade 3 Bullous dermatitis NCIBlisters covering >30% BSA; limiting self care ADL Grade 3 Bullous dermatitisPTCTCAE E13620 Grade 3 Bullous dermatitis Grade 3 Burn NCIModerate to major debridement or reconstruction indicated Grade 3 BurnPTCTCAE E11672 Grade 3 Burn Grade 3 Buttock pain NCISevere pain; limiting self care ADL Grade 3 Buttock painPTCTCAE E12399 Grade 3 Buttock pain Grade 3 CD4 lymphocytes decreased NCI<200 - 50/mm3; <0.2 x 0.05 - 10e9 /L Grade 3 CD4 lymphocytes decreasedPTCTCAE E12125 Grade 3 CD4 lymphocytes decreased Grade 3 CPK increased NCI>5 x ULN - 10 x ULN Grade 3 CPK increasedPTCTCAE E12135 Grade 3 CPK increased Grade 3 Capillary leak syndrome NCISevere symptoms; intervention indicated Grade 3 Capillary leak syndromePTCTCAE E13768 Grade 3 Capillary leak syndrome Grade 3 Carbon monoxide diffusing capacity decreased NCIAsymptomatic decrease of >8 units drop; >5 units drop along with the presence of pulmonary symptoms (e.g. , >Grade 2 hypoxia or >Grade 2 or higher dyspnea) Grade 3 Carbon monoxide diffusing capacity decreasedPTCTCAE E12115 Grade 3 Carbon monoxide diffusing capacity decreased Grade 3 Cardiac disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Cardiac disorders - Other, specifyPTCTCAE E10107 Grade 3 Cardiac disorders - Other, specify Grade 3 Cardiac troponin I increased NCILevels consistent with myocardial infarction as defined by the manufacturer Grade 3 Cardiac troponin I increasedPTCTCAE E12118 Grade 3 Cardiac troponin I increased Grade 3 Cardiac troponin T increased NCILevels consistent with myocardial infarction as defined by the manufacturer Grade 3 Cardiac troponin T increasedPTCTCAE E12121 Grade 3 Cardiac troponin T increased Grade 3 Cataract NCISymptomatic with marked decrease in visual acuity (worse than 20/40 but better than 20/200); operative intervention indicated (e.g., cataract surgery) Grade 3 CataractPTCTCAE E10353 Grade 3 Cataract Grade 3 Catheter related infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Catheter related infectionPTCTCAE E11330 Grade 3 Catheter related infection Grade 3 Cecal hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Cecal hemorrhagePTCTCAE E10514 Grade 3 Cecal hemorrhage Grade 3 Cecal infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Cecal infectionPTCTCAE E11334 Grade 3 Cecal infection Grade 3 Central nervous system necrosis NCISevere symptoms; medical intervention indicated Grade 3 Central nervous system necrosisPTCTCAE E12608 Grade 3 Central nervous system necrosis Grade 3 Cerebrospinal fluid leakage NCISevere symptoms; medical intervention indicated Grade 3 Cerebrospinal fluid leakagePTCTCAE E12614 Grade 3 Cerebrospinal fluid leakage Grade 3 Cervicitis infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Cervicitis infectionPTCTCAE E11339 Grade 3 Cervicitis infection Grade 3 Cheilitis NCISevere symptoms; limiting self care ADL; intervention indicated Grade 3 CheilitisPTCTCAE E10520 Grade 3 Cheilitis Grade 3 Chest pain - cardiac NCIPain at rest; limiting self care ADL Grade 3 Chest pain - cardiacPTCTCAE E10113 Grade 3 Chest pain - cardiac Grade 3 Chest wall pain NCISevere pain; limiting self care ADL Grade 3 Chest wall painPTCTCAE E12403 Grade 3 Chest wall pain Grade 3 Chills NCISevere or prolonged, not responsive to narcotics Grade 3 ChillsPTCTCAE E11077 Grade 3 Chills Grade 3 Cholecystitis NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 CholecystitisPTCTCAE E11186 Grade 3 Cholecystitis Grade 3 Cholesterol high NCI>400 - 500 mg/dL; >10.34 - 12.92 mmol/L Grade 3 Cholesterol highPTCTCAE E12130 Grade 3 Cholesterol high Grade 3 Chronic kidney disease NCIeGFR or CrCl 29 - 15 ml/min/1.73 m2 Grade 3 Chronic kidney diseasePTCTCAE E12991 Grade 3 Chronic kidney disease Grade 3 Chylothorax NCISevere symptoms; elective operative intervention indicated Grade 3 ChylothoraxPTCTCAE E13361 Grade 3 Chylothorax Grade 3 Cognitive disturbance NCISevere cognitive disability; significant impairment of work/school/life performance Grade 3 Cognitive disturbancePTCTCAE E12620 Grade 3 Cognitive disturbance Grade 3 Colitis NCISevere abdominal pain; change in bowel habits; medical intervention indicated; peritoneal signs Grade 3 ColitisPTCTCAE E10524 Grade 3 Colitis Grade 3 Colonic fistula NCISeverely altered GI function; bowel rest, TPN or hospitalization indicated; elective operative intervention indicated Grade 3 Colonic fistulaPTCTCAE E10530 Grade 3 Colonic fistula Grade 3 Colonic hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Colonic hemorrhagePTCTCAE E10536 Grade 3 Colonic hemorrhage Grade 3 Colonic obstruction NCIHospitalization indicated; elective operative intervention indicated; disabling Grade 3 Colonic obstructionPTCTCAE E10542 Grade 3 Colonic obstruction Grade 3 Colonic perforation NCISevere symptoms; elective operative intervention indicated Grade 3 Colonic perforationPTCTCAE E10547 Grade 3 Colonic perforation Grade 3 Colonic stenosis NCISeverely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated Grade 3 Colonic stenosisPTCTCAE E10553 Grade 3 Colonic stenosis Grade 3 Colonic ulcer NCISeverely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling Grade 3 Colonic ulcerPTCTCAE E10559 Grade 3 Colonic ulcer Grade 3 Concentration impairment NCISevere impairment in attention or decreased level of concentration; limiting self care ADL Grade 3 Concentration impairmentPTCTCAE E12624 Grade 3 Concentration impairment Grade 3 Conduction disorder NCISevere symptoms; intervention indicated Grade 3 Conduction disorderPTCTCAE E10117 Grade 3 Conduction disorder Grade 3 Confusion NCISevere disorientation; limiting self care ADL Grade 3 ConfusionPTCTCAE E12892 Grade 3 Confusion Grade 3 Congenital, familial and genetic disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Congenital, familial and genetic disorders - Other, specifyPTCTCAE E10253 Grade 3 Congenital, familial and genetic disorders - Other, specify Grade 3 Conjunctivitis NCILimiting self care ADL Grade 3 ConjunctivitisPTCTCAE E10358 Grade 3 Conjunctivitis Grade 3 Conjunctivitis infective NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Conjunctivitis infectivePTCTCAE E11344 Grade 3 Conjunctivitis infective Grade 3 Constipation NCIObstipation with manual evacuation indicated; limiting self care ADL Grade 3 ConstipationPTCTCAE E10565 Grade 3 Constipation Grade 3 Constrictive pericarditis NCISymptomatic heart failure or other cardiac symptoms, responsive to intervention Grade 3 Constrictive pericarditisPTCTCAE E10121 Grade 3 Constrictive pericarditis Grade 3 Corneal infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Corneal infectionPTCTCAE E11349 Grade 3 Corneal infection Grade 3 Corneal ulcer NCILimiting self care ADL; declining vision (worse than 20/40 but better than 20/200) Grade 3 Corneal ulcerPTCTCAE E10361 Grade 3 Corneal ulcer Grade 3 Cough NCISevere symptoms; limiting self care ADL Grade 3 CoughPTCTCAE E13367 Grade 3 Cough Grade 3 Cranial nerve infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Cranial nerve infectionPTCTCAE E11353 Grade 3 Cranial nerve infection Grade 3 Creatinine increased NCI>3.0 baseline; >3.0 - 6.0 x ULN Grade 3 Creatinine increasedPTCTCAE E12140 Grade 3 Creatinine increased Grade 3 Cushingoid NCISevere symptoms, medical intervention or hospitalization indicated Grade 3 CushingoidPTCTCAE E10307 Grade 3 Cushingoid Grade 3 Cystitis noninfective NCIGross hematuria; transfusion, IV medications or hospitalization indicated; elective endoscopic, radiologic or operative intervention indicated Grade 3 Cystitis noninfectivePTCTCAE E12997 Grade 3 Cystitis noninfective Grade 3 Cytokine release syndrome NCIProlonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae (e.g., renal impairment, pulmonary infiltrates) Grade 3 Cytokine release syndromePTCTCAE E11267 Grade 3 Cytokine release syndrome Grade 3 Dehydration NCIIV fluids or hospitalization indicated Grade 3 DehydrationPTCTCAE E12261 Grade 3 Dehydration Grade 3 Delayed puberty NCINo breast development by age 14 yrs for females; no increase in testes volume or no Tanner Stage 2 by age 16 yrs for males; hormone replacement indicated Grade 3 Delayed pubertyPTCTCAE E10310 Grade 3 Delayed puberty Grade 3 Delirium NCISevere and acute confusional state; limiting self care ADL; hospitalization indicated Grade 3 DeliriumPTCTCAE E12901 Grade 3 Delirium Grade 3 Delusions NCISevere delusional symptoms; hospitalization not indicated Grade 3 DelusionsPTCTCAE E12906 Grade 3 Delusions Grade 3 Dental caries NCIDental caries resulting in pulpitis or periapical abscess or resulting in tooth loss Grade 3 Dental cariesPTCTCAE E10571 Grade 3 Dental caries Grade 3 Depressed level of consciousness NCIDifficult to arouse Grade 3 Depressed level of consciousnessPTCTCAE E12628 Grade 3 Depressed level of consciousness Grade 3 Depression NCISevere depressive symptoms; limiting self care ADL; hospitalization not indicated Grade 3 DepressionPTCTCAE E12912 Grade 3 Depression Grade 3 Dermatitis radiation NCIMoist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion Grade 3 Dermatitis radiationPTCTCAE E11678 Grade 3 Dermatitis radiation Grade 3 Device related infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Device related infectionPTCTCAE E11357 Grade 3 Device related infection Grade 3 Diarrhea NCIIncrease of >=7 stools per day over baseline; incontinence; hospitalization indicated; severe increase in ostomy output compared to baseline; limiting self care ADL Grade 3 DiarrheaPTCTCAE E10575 Grade 3 Diarrhea Grade 3 Disseminated intravascular coagulation NCILaboratory findings and bleeding Grade 3 Disseminated intravascular coagulationPTCTCAE E10030 Grade 3 Disseminated intravascular coagulation Grade 3 Dizziness NCISevere unsteadiness or sensation of movement; limiting self care ADL Grade 3 DizzinessPTCTCAE E12634 Grade 3 Dizziness Grade 3 Dry eye NCIDecrease in visual acuity (<20/40); limiting self care ADL Grade 3 Dry eyePTCTCAE E10366 Grade 3 Dry eye Grade 3 Dry mouth NCIInability to adequately aliment orally; tube feeding or TPN indicated; unstimulated saliva <0.1 ml/min Grade 3 Dry mouthPTCTCAE E10581 Grade 3 Dry mouth Grade 3 Dry skin NCICovering >30% BSA and associated with pruritus; limiting self care ADL Grade 3 Dry skinPTCTCAE E13626 Grade 3 Dry skin Grade 3 Duodenal fistula NCISeverely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated Grade 3 Duodenal fistulaPTCTCAE E10585 Grade 3 Duodenal fistula Grade 3 Duodenal hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Duodenal hemorrhagePTCTCAE E10591 Grade 3 Duodenal hemorrhage Grade 3 Duodenal infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Duodenal infectionPTCTCAE E11362 Grade 3 Duodenal infection Grade 3 Duodenal obstruction NCIHospitalization or elective operative intervention indicated; disabling Grade 3 Duodenal obstructionPTCTCAE E10597 Grade 3 Duodenal obstruction Grade 3 Duodenal perforation NCISevere symptoms; elective operative intervention indicated Grade 3 Duodenal perforationPTCTCAE E10602 Grade 3 Duodenal perforation Grade 3 Duodenal stenosis NCISeverely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated Grade 3 Duodenal stenosisPTCTCAE E10608 Grade 3 Duodenal stenosis Grade 3 Duodenal ulcer NCISeverely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care ADL; disabling Grade 3 Duodenal ulcerPTCTCAE E10614 Grade 3 Duodenal ulcer Grade 3 Dysarthria NCISevere impairment of articulation or slurred speech Grade 3 DysarthriaPTCTCAE E12638 Grade 3 Dysarthria Grade 3 Dysesthesia NCISevere sensory alteration; limiting self care ADL Grade 3 DysesthesiaPTCTCAE E12642 Grade 3 Dysesthesia Grade 3 Dysmenorrhea NCISevere symptoms; limiting self care ADL Grade 3 DysmenorrheaPTCTCAE E13080 Grade 3 Dysmenorrhea Grade 3 Dyspareunia NCISevere discomfort or pain associated with vaginal penetration; discomfort or pain unrelieved by vaginal lubricants or estrogen Grade 3 DyspareuniaPTCTCAE E13084 Grade 3 Dyspareunia Grade 3 Dyspepsia NCISevere symptoms; surgical intervention indicated Grade 3 DyspepsiaPTCTCAE E10620 Grade 3 Dyspepsia Grade 3 Dysphagia NCISeverely altered eating/swallowing; tube feeding or TPN or hospitalization indicated Grade 3 DysphagiaPTCTCAE E10624 Grade 3 Dysphagia Grade 3 Dysphasia NCISevere receptive or expressive characteristics; impairing ability to read, write or communicate intelligibly Grade 3 DysphasiaPTCTCAE E12649 Grade 3 Dysphasia Grade 3 Dyspnea NCIShortness of breath at rest; limiting self care ADL Grade 3 DyspneaPTCTCAE E13371 Grade 3 Dyspnea Grade 3 Ear and labyrinth disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Ear and labyrinth disorders - Other, specifyPTCTCAE E10259 Grade 3 Ear and labyrinth disorders - Other, specify Grade 3 Ear pain NCISevere pain; limiting self care ADL Grade 3 Ear painPTCTCAE E10265 Grade 3 Ear pain Grade 3 Edema face NCISevere swelling; limiting self care ADL Grade 3 Edema facePTCTCAE E11085 Grade 3 Edema face Grade 3 Edema limbs NCI>30% inter-limb discrepancy in volume; gross deviation from normal anatomic contour; limiting self care ADL Grade 3 Edema limbsPTCTCAE E11089 Grade 3 Edema limbs Grade 3 Edema trunk NCIGross deviation from normal anatomic contour; limiting self care ADL Grade 3 Edema trunkPTCTCAE E11093 Grade 3 Edema trunk Grade 3 Ejection fraction decreased NCIResting ejection fraction (EF) 39 - 20%; >20% drop from baseline Grade 3 Ejection fraction decreasedPTCTCAE E12144 Grade 3 Ejection fraction decreased Grade 3 Electrocardiogram QT corrected interval prolonged NCIQTc >= 501 ms on at least two separate ECGs Grade 3 Electrocardiogram QT corrected interval prolongedPTCTCAE E12149 Grade 3 Electrocardiogram QT corrected interval prolonged Grade 3 Encephalitis infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; severe changes in mental status; self-limited seizure activity; focal neurologic abnormalities Grade 3 Encephalitis infectionPTCTCAE E11366 Grade 3 Encephalitis infection Grade 3 Encephalomyelitis infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Encephalomyelitis infectionPTCTCAE E11370 Grade 3 Encephalomyelitis infection Grade 3 Encephalopathy NCISevere symptoms; limiting self care ADL Grade 3 EncephalopathyPTCTCAE E12655 Grade 3 Encephalopathy Grade 3 Endocarditis infective NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Endocarditis infectivePTCTCAE E11374 Grade 3 Endocarditis infective Grade 3 Endocrine disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Endocrine disorders - Other, specifyPTCTCAE E10314 Grade 3 Endocrine disorders - Other, specify Grade 3 Endophthalmitis NCISystemic intervention or hospitalization indicated Grade 3 EndophthalmitisPTCTCAE E11379 Grade 3 Endophthalmitis Grade 3 Enterocolitis NCISevere or persistent abdominal pain; fever; ileus; peritoneal signs Grade 3 EnterocolitisPTCTCAE E10630 Grade 3 Enterocolitis Grade 3 Enterocolitis infectious NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated; profuse watery diarrhea with signs of hypovolemia; bloody diarrhea; fever; severe abdominal pain; hospitalization indicated Grade 3 Enterocolitis infectiousPTCTCAE E11383 Grade 3 Enterocolitis infectious Grade 3 Enterovesical fistula NCISevere, medically significant; medical intervention indicated Grade 3 Enterovesical fistulaPTCTCAE E10636 Grade 3 Enterovesical fistula Grade 3 Epistaxis NCITransfusion, radiologic, endoscopic, or operative intervention indicated (e.g., hemostasis of bleeding site) Grade 3 EpistaxisPTCTCAE E13377 Grade 3 Epistaxis Grade 3 Erectile dysfunction NCIDecrease in erectile function (frequency/rigidity of erections) but erectile intervention not helpful (e.g., medication or mechanical devices such as penile pump); placement of a permanent penile prosthesis indicated (not previously present) Grade 3 Erectile dysfunctionPTCTCAE E13091 Grade 3 Erectile dysfunction Grade 3 Erythema multiforme NCITarget lesions covering >30% BSA and associated with oral or genital erosions Grade 3 Erythema multiformePTCTCAE E13630 Grade 3 Erythema multiforme Grade 3 Erythroderma NCIErythema covering >90% BSA with associated symptoms (e.g., pruritus or tenderness); limiting self care ADL Grade 3 ErythrodermaPTCTCAE E13635 Grade 3 Erythroderma Grade 3 Esophageal anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Esophageal anastomotic leakPTCTCAE E11684 Grade 3 Esophageal anastomotic leak Grade 3 Esophageal fistula NCISeverely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated Grade 3 Esophageal fistulaPTCTCAE E10642 Grade 3 Esophageal fistula Grade 3 Esophageal hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Esophageal hemorrhagePTCTCAE E10648 Grade 3 Esophageal hemorrhage Grade 3 Esophageal infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Esophageal infectionPTCTCAE E11388 Grade 3 Esophageal infection Grade 3 Esophageal necrosis NCIInability to aliment adequately by GI tract; radiologic, endoscopic, or operative intervention indicated Grade 3 Esophageal necrosisPTCTCAE E10652 Grade 3 Esophageal necrosis Grade 3 Esophageal obstruction NCIHospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling Grade 3 Esophageal obstructionPTCTCAE E10658 Grade 3 Esophageal obstruction Grade 3 Esophageal pain NCISevere pain; limiting self care ADL Grade 3 Esophageal painPTCTCAE E10664 Grade 3 Esophageal pain Grade 3 Esophageal perforation NCISevere symptoms; elective operative intervention indicated Grade 3 Esophageal perforationPTCTCAE E10667 Grade 3 Esophageal perforation Grade 3 Esophageal stenosis NCISeverely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated Grade 3 Esophageal stenosisPTCTCAE E10673 Grade 3 Esophageal stenosis Grade 3 Esophageal ulcer NCISeverely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care ADL; disabling Grade 3 Esophageal ulcerPTCTCAE E10679 Grade 3 Esophageal ulcer Grade 3 Esophageal varices hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Esophageal varices hemorrhagePTCTCAE E10684 Grade 3 Esophageal varices hemorrhage Grade 3 Esophagitis NCISeverely altered eating/swallowing; tube feeding, TPN or hospitalization indicated Grade 3 EsophagitisPTCTCAE E10690 Grade 3 Esophagitis Grade 3 Euphoria NCISevere mood elevation (e.g., hypomania) Grade 3 EuphoriaPTCTCAE E12918 Grade 3 Euphoria Grade 3 Exostosis NCISevere symptoms; limiting self care ADL; elective operative intervention indicated Grade 3 ExostosisPTCTCAE E12407 Grade 3 Exostosis Grade 3 External ear inflammation NCIExternal otitis with mastoiditis; stenosis or osteomyelitis; necrosis of soft tissue or bone Grade 3 External ear inflammationPTCTCAE E10269 Grade 3 External ear inflammation Grade 3 External ear pain NCISevere pain; limiting self care ADL Grade 3 External ear painPTCTCAE E10275 Grade 3 External ear pain Grade 3 Extraocular muscle paresis NCILimiting self care ADL; disabling Grade 3 Extraocular muscle paresisPTCTCAE E10370 Grade 3 Extraocular muscle paresis Grade 3 Extrapyramidal disorder NCISevere involuntary movements or torticollis; limiting self care ADL Grade 3 Extrapyramidal disorderPTCTCAE E12661 Grade 3 Extrapyramidal disorder Grade 3 Eye disorders - Other, specify NCISevere or medically significant but not immediately sight-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Eye disorders - Other, specifyPTCTCAE E10374 Grade 3 Eye disorders - Other, specify Grade 3 Eye infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Eye infectionPTCTCAE E11393 Grade 3 Eye infection Grade 3 Eye pain NCISevere pain; limiting self care ADL Grade 3 Eye painPTCTCAE E10379 Grade 3 Eye pain Grade 3 Eyelid function disorder NCILimiting self care ADL; operative intervention indicated Grade 3 Eyelid function disorderPTCTCAE E10383 Grade 3 Eyelid function disorder Grade 3 Facial muscle weakness NCISevere symptoms; limiting self care ADL Grade 3 Facial muscle weaknessPTCTCAE E12667 Grade 3 Facial muscle weakness Grade 3 Facial nerve disorder NCISevere symptoms; limiting self care ADL Grade 3 Facial nerve disorderPTCTCAE E12671 Grade 3 Facial nerve disorder Grade 3 Facial pain NCISevere pain; limiting self care ADL Grade 3 Facial painPTCTCAE E11097 Grade 3 Facial pain Grade 3 Fall NCIHospitalization indicated Grade 3 FallPTCTCAE E11690 Grade 3 Fall Grade 3 Fallopian tube anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Fallopian tube anastomotic leakPTCTCAE E11694 Grade 3 Fallopian tube anastomotic leak Grade 3 Fallopian tube obstruction NCISevere symptoms; elective operative intervention indicated Grade 3 Fallopian tube obstructionPTCTCAE E13095 Grade 3 Fallopian tube obstruction Grade 3 Fallopian tube perforation NCISevere symptoms; elective operative intervention indicated Grade 3 Fallopian tube perforationPTCTCAE E11700 Grade 3 Fallopian tube perforation Grade 3 Fallopian tube stenosis NCISevere symptoms; elective operative intervention indicated Grade 3 Fallopian tube stenosisPTCTCAE E13099 Grade 3 Fallopian tube stenosis Grade 3 Fat atrophy NCICovering >30% BSA; associated with erythema or tenderness; limiting self-care ADL Grade 3 Fat atrophyPTCTCAE E13641 Grade 3 Fat atrophy Grade 3 Fatigue NCIFatigue not relieved by rest, limiting self care ADL Grade 3 FatiguePTCTCAE E11101 Grade 3 Fatigue Grade 3 Febrile neutropenia NCIANC <1000/mm3 with a single temperature of >38.3 degrees C (101 degrees F) or a sustained temperature of >=38 degrees C (100.4 degrees F) for more than one hour. Grade 3 Febrile neutropeniaPTCTCAE E10034 Grade 3 Febrile neutropenia Grade 3 Fecal incontinence NCISevere symptoms; elective operative intervention indicated Grade 3 Fecal incontinencePTCTCAE E10696 Grade 3 Fecal incontinence Grade 3 Female genital tract fistula NCISevere symptoms; elective operative intervention indicated Grade 3 Female genital tract fistulaPTCTCAE E13105 Grade 3 Female genital tract fistula Grade 3 Fetal growth retardation NCI<5% percentile of weight for gestational age Grade 3 Fetal growth retardationPTCTCAE E12859 Grade 3 Fetal growth retardation Grade 3 Fever NCI>40.0 degrees C (>104.0 degrees F) for <=24 hrs Grade 3 FeverPTCTCAE E11105 Grade 3 Fever Grade 3 Fibrinogen decreased NCI<0.5 - 0.25 x LLN or 50 - <75% decrease from baseline Grade 3 Fibrinogen decreasedPTCTCAE E12154 Grade 3 Fibrinogen decreased Grade 3 Fibrosis deep connective tissue NCISevere induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g. mouth, anus); limiting self care ADL Grade 3 Fibrosis deep connective tissuePTCTCAE E12411 Grade 3 Fibrosis deep connective tissue Grade 3 Flank pain NCISevere pain; limiting self care ADL Grade 3 Flank painPTCTCAE E12417 Grade 3 Flank pain Grade 3 Flashing lights NCILimiting self care ADL Grade 3 Flashing lightsPTCTCAE E10387 Grade 3 Flashing lights Grade 3 Floaters NCILimiting self care ADL Grade 3 FloatersPTCTCAE E10391 Grade 3 Floaters Grade 3 Flu like symptoms NCISevere symptoms; limiting self care ADL Grade 3 Flu like symptomsPTCTCAE E11111 Grade 3 Flu like symptoms Grade 3 Flushing NCISymptomatic, associated with hypotension and/or tachycardia; limiting self care ADL Grade 3 FlushingPTCTCAE E13774 Grade 3 Flushing Grade 3 Forced expiratory volume decreased NCI50 - 59% Grade 3 Forced expiratory volume decreasedPTCTCAE E12159 Grade 3 Forced expiratory volume decreased Grade 3 Fracture NCISevere symptoms; displaced or open wound with bone exposure; disabling; operative intervention indicated Grade 3 FracturePTCTCAE E11706 Grade 3 Fracture Grade 3 GGT increased NCI>5.0 - 20.0 x ULN Grade 3 GGT increasedPTCTCAE E12164 Grade 3 GGT increased Grade 3 Gait disturbance NCIDisabling; limiting self care ADL Grade 3 Gait disturbancePTCTCAE E11115 Grade 3 Gait disturbance Grade 3 Gallbladder fistula NCISymptomatic or severely altered GI function; TPN indicated; radiologic, endoscopic or elective operative intervention indicated Grade 3 Gallbladder fistulaPTCTCAE E11192 Grade 3 Gallbladder fistula Grade 3 Gallbladder infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Gallbladder infectionPTCTCAE E11397 Grade 3 Gallbladder infection Grade 3 Gallbladder obstruction NCISymptomatic and severely altered GI function; tube feeding, TPN or hospitalization indicated; non-emergent operative intervention indicated Grade 3 Gallbladder obstructionPTCTCAE E11201 Grade 3 Gallbladder obstruction Grade 3 Gallbladder pain NCISevere pain; limiting self care ADL Grade 3 Gallbladder painPTCTCAE E11207 Grade 3 Gallbladder pain Grade 3 Gastric anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Gastric anastomotic leakPTCTCAE E11712 Grade 3 Gastric anastomotic leak Grade 3 Gastric fistula NCISeverely altered GI function; bowel rest; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated Grade 3 Gastric fistulaPTCTCAE E10703 Grade 3 Gastric fistula Grade 3 Gastric hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Gastric hemorrhagePTCTCAE E10709 Grade 3 Gastric hemorrhage Grade 3 Gastric necrosis NCIInability to aliment adequately by GI tract; radiologic, endoscopic, or operative intervention indicated Grade 3 Gastric necrosisPTCTCAE E10713 Grade 3 Gastric necrosis Grade 3 Gastric perforation NCISevere symptoms; elective operative intervention indicated Grade 3 Gastric perforationPTCTCAE E10718 Grade 3 Gastric perforation Grade 3 Gastric stenosis NCISeverely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated Grade 3 Gastric stenosisPTCTCAE E10724 Grade 3 Gastric stenosis Grade 3 Gastric ulcer NCISeverely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care ADL; disabling Grade 3 Gastric ulcerPTCTCAE E10730 Grade 3 Gastric ulcer Grade 3 Gastritis NCISeverely altered eating or gastric function; TPN or hospitalization indicated Grade 3 GastritisPTCTCAE E10736 Grade 3 Gastritis Grade 3 Gastroesophageal reflux disease NCISevere symptoms; surgical intervention indicated Grade 3 Gastroesophageal reflux diseasePTCTCAE E10742 Grade 3 Gastroesophageal reflux disease Grade 3 Gastrointestinal anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Gastrointestinal anastomotic leakPTCTCAE E11718 Grade 3 Gastrointestinal anastomotic leak Grade 3 Gastrointestinal disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Gastrointestinal disorders - Other, specifyPTCTCAE E10746 Grade 3 Gastrointestinal disorders - Other, specify Grade 3 Gastrointestinal fistula NCISeverely altered GI function; tube feeding, TPN or hospitalization indicated Grade 3 Gastrointestinal fistulaPTCTCAE E10752 Grade 3 Gastrointestinal fistula Grade 3 Gastrointestinal pain NCISevere pain; limiting self care ADL Grade 3 Gastrointestinal painPTCTCAE E10758 Grade 3 Gastrointestinal pain Grade 3 Gastrointestinal stoma necrosis NCISevere symptoms; hospitalization or elective operative intervention indicated Grade 3 Gastrointestinal stoma necrosisPTCTCAE E11723 Grade 3 Gastrointestinal stoma necrosis Grade 3 Gastroparesis NCIWeight loss; refractory to medical intervention; unable to maintain nutrition orally Grade 3 GastroparesisPTCTCAE E10762 Grade 3 Gastroparesis Grade 3 General disorders and administration site conditions - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 General disorders and administration site conditions - Other, specifyPTCTCAE E11119 Grade 3 General disorders and administration site conditions - Other, specify Grade 3 Generalized muscle weakness NCIWeakness limiting self care ADL; disabling Grade 3 Generalized muscle weaknessPTCTCAE E12421 Grade 3 Generalized muscle weakness Grade 3 Genital edema NCILymphorrhea; gross deviation from normal anatomic contour; limiting self care ADL Grade 3 Genital edemaPTCTCAE E13114 Grade 3 Genital edema Grade 3 Gingival pain NCISevere pain; inability to aliment orally Grade 3 Gingival painPTCTCAE E10766 Grade 3 Gingival pain Grade 3 Glaucoma NCIEIOP causing marked visual field deficits (e.g., involving both superior and inferior visual fields); operative intervention indicated; limiting self care ADL Grade 3 GlaucomaPTCTCAE E10395 Grade 3 Glaucoma Grade 3 Glossopharyngeal nerve disorder NCISevere symptoms; limiting self care ADL Grade 3 Glossopharyngeal nerve disorderPTCTCAE E12675 Grade 3 Glossopharyngeal nerve disorder Grade 3 Glucose intolerance NCISevere symptoms; insulin indicated Grade 3 Glucose intolerancePTCTCAE E12267 Grade 3 Glucose intolerance Grade 3 Growth suppression NCIReduction in growth velocity of >=50% ideally measured over the period of a year Grade 3 Growth suppressionPTCTCAE E12425 Grade 3 Growth suppression Grade 3 Gum infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Gum infectionPTCTCAE E11403 Grade 3 Gum infection Grade 3 Gynecomastia NCISevere symptoms; elective operative intervention indicated Grade 3 GynecomastiaPTCTCAE E13118 Grade 3 Gynecomastia Grade 3 Hallucinations NCISevere hallucinations; hospitalization not indicated Grade 3 HallucinationsPTCTCAE E12922 Grade 3 Hallucinations Grade 3 Head soft tissue necrosis NCIOperative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) Grade 3 Head soft tissue necrosisPTCTCAE E12428 Grade 3 Head soft tissue necrosis Grade 3 Headache NCISevere pain; limiting self care ADL Grade 3 HeadachePTCTCAE E12681 Grade 3 Headache Grade 3 Hearing impaired NCIAdults enrolled in Monitoring Program (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift of >25 dB averaged at 3 contiguous test frequencies in at least one ear; therapeutic intervention indicated. Adults not enrolled in Monitoring Program: hearing loss with hearing aid or intervention indicated; limiting self care ADL. Pediatric (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): hearing loss sufficient to indicate therapeutic intervention, including hearing aids; threshold shift >20 dB at 3 kHz and above in at least one ear; additional speech-language related services indicated. Grade 3 Hearing impairedPTCTCAE E10279 Grade 3 Hearing impaired Grade 3 Heart failure NCISevere with symptoms at rest or with minimal activity or exertion; intervention indicated Grade 3 Heart failurePTCTCAE E10127 Grade 3 Heart failure Grade 3 Hematoma NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 HematomaPTCTCAE E13778 Grade 3 Hematoma Grade 3 Hematosalpinx NCISevere bleeding; transfusion indicated; radiologic or endoscopic intervention indicated Grade 3 HematosalpinxPTCTCAE E13122 Grade 3 Hematosalpinx Grade 3 Hematuria NCIGross hematuria; transfusion, IV medications or hospitalization indicated; elective endoscopic, radiologic or operative intervention indicated; limiting self care ADL Grade 3 HematuriaPTCTCAE E13003 Grade 3 Hematuria Grade 3 Hemoglobin increased NCIIncrease in >4 gm/dL above ULN or above baseline if baseline is above ULN Grade 3 Hemoglobin increasedPTCTCAE E12174 Grade 3 Hemoglobin increased Grade 3 Hemolysis NCITransfusion or medical intervention indicated (e.g., steroids) Grade 3 HemolysisPTCTCAE E10040 Grade 3 Hemolysis Grade 3 Hemolytic uremic syndrome NCILaboratory findings with clinical consequences (e.g., renal insufficiency, petechiae) Grade 3 Hemolytic uremic syndromePTCTCAE E10045 Grade 3 Hemolytic uremic syndrome Grade 3 Hemorrhoidal hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Hemorrhoidal hemorrhagePTCTCAE E10770 Grade 3 Hemorrhoidal hemorrhage Grade 3 Hemorrhoids NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 HemorrhoidsPTCTCAE E10776 Grade 3 Hemorrhoids Grade 3 Hepatic failure NCIAsterixis; mild encephalopathy; limiting self care ADL Grade 3 Hepatic failurePTCTCAE E11212 Grade 3 Hepatic failure Grade 3 Hepatic hemorrhage NCITransfusion indicated Grade 3 Hepatic hemorrhagePTCTCAE E11218 Grade 3 Hepatic hemorrhage Grade 3 Hepatic infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Hepatic infectionPTCTCAE E11407 Grade 3 Hepatic infection Grade 3 Hepatic pain NCISevere pain; limiting self care ADL Grade 3 Hepatic painPTCTCAE E11227 Grade 3 Hepatic pain Grade 3 Hepatitis viral NCISymptomatic liver dysfunction; fibrosis by biopsy; compensated cirrhosis; reactivation of chronic hepatitis Grade 3 Hepatitis viralPTCTCAE E11412 Grade 3 Hepatitis viral Grade 3 Hepatobiliary disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Hepatobiliary disorders - Other, specifyPTCTCAE E11231 Grade 3 Hepatobiliary disorders - Other, specify Grade 3 Hiccups NCISevere symptoms; interfering with sleep; limiting self care ADL Grade 3 HiccupsPTCTCAE E13383 Grade 3 Hiccups Grade 3 Hip fracture NCISevere pain; hospitalization or intervention indicated for pain control (e.g., traction); operative intervention indicated Grade 3 Hip fracturePTCTCAE E11728 Grade 3 Hip fracture Grade 3 Hoarseness NCISevere voice changes including predominantly whispered speech Grade 3 HoarsenessPTCTCAE E13387 Grade 3 Hoarseness Grade 3 Hot flashes NCISevere symptoms; limiting self care ADL Grade 3 Hot flashesPTCTCAE E13784 Grade 3 Hot flashes Grade 3 Hydrocephalus NCISevere symptoms or neurological deficit; intervention indicated Grade 3 HydrocephalusPTCTCAE E12685 Grade 3 Hydrocephalus Grade 3 Hypercalcemia NCICorrected serum calcium of >12.5 - 13.5 mg/dL; >3.1 - 3.4 mmol/L; Ionized calcium >1.6 - 1.8 mmol/L; hospitalization indicated Grade 3 HypercalcemiaPTCTCAE E12273 Grade 3 Hypercalcemia Grade 3 Hyperglycemia NCI>250 - 500 mg/dL; >13.9 - 27.8 mmol/L; hospitalization indicated Grade 3 HyperglycemiaPTCTCAE E12279 Grade 3 Hyperglycemia Grade 3 Hyperhidrosis NCIGeneralized involving sites other than palms, soles, or axillae; associated with electrolyte/hemodynamic imbalance Grade 3 HyperhidrosisPTCTCAE E13648 Grade 3 Hyperhidrosis Grade 3 Hyperkalemia NCI>6.0 - 7.0 mmol/L; hospitalization indicated Grade 3 HyperkalemiaPTCTCAE E12285 Grade 3 Hyperkalemia Grade 3 Hypermagnesemia NCI>3.0 - 8.0 mg/dL; >1.23 - 3.30 mmol/L Grade 3 HypermagnesemiaPTCTCAE E12290 Grade 3 Hypermagnesemia Grade 3 Hypernatremia NCI>155 - 160 mmol/L; hospitalization indicated Grade 3 HypernatremiaPTCTCAE E12296 Grade 3 Hypernatremia Grade 3 Hypersomnia NCISevere increased need for sleep Grade 3 HypersomniaPTCTCAE E12691 Grade 3 Hypersomnia Grade 3 Hypertension NCIStage 2 hypertension (systolic BP >=160 mm Hg or diastolic BP >=100 mm Hg); medical intervention indicated; more than one drug or more intensive therapy than previously used indicated Pediatric: Same as adult Grade 3 HypertensionPTCTCAE E13788 Grade 3 Hypertension Grade 3 Hyperthyroidism NCISevere symptoms; limiting self care ADL; hospitalization indicated Grade 3 HyperthyroidismPTCTCAE E10325 Grade 3 Hyperthyroidism Grade 3 Hypertriglyceridemia NCI>500 mg/dL - 1000 mg/dL; >5.7 mmol/L - 11.4 mmol/L Grade 3 HypertriglyceridemiaPTCTCAE E12302 Grade 3 Hypertriglyceridemia Grade 3 Hyperuricemia NCI>ULN - 10 mg/dL (0.59 mmol/L) with physiologic consequences Grade 3 HyperuricemiaPTCTCAE E12307 Grade 3 Hyperuricemia Grade 3 Hypoalbuminemia NCI<2 g/dL; <20 g/L Grade 3 HypoalbuminemiaPTCTCAE E12313 Grade 3 Hypoalbuminemia Grade 3 Hypocalcemia NCICorrected serum calcium of <7.0 - 6.0 mg/dL; <1.75 - 1.5 mmol/L; Ionized calcium <0.9 - 0.8 mmol/L; hospitalization indicated Grade 3 HypocalcemiaPTCTCAE E12319 Grade 3 Hypocalcemia Grade 3 Hypoglossal nerve disorder NCISevere symptoms; limiting self care ADL Grade 3 Hypoglossal nerve disorderPTCTCAE E12695 Grade 3 Hypoglossal nerve disorder Grade 3 Hypoglycemia NCI<40 - 30 mg/dL; <2.2 - 1.7 mmol/L Grade 3 HypoglycemiaPTCTCAE E12324 Grade 3 Hypoglycemia Grade 3 Hypohidrosis NCIIncrease in body temperature; limiting self care ADL Grade 3 HypohidrosisPTCTCAE E13654 Grade 3 Hypohidrosis Grade 3 Hypokalemia NCI<3.0 - 2.5 mmol/L; hospitalization indicated Grade 3 HypokalemiaPTCTCAE E12330 Grade 3 Hypokalemia Grade 3 Hypomagnesemia NCI<0.9 - 0.7 mg/dL; <0.4 - 0.3 mmol/L Grade 3 HypomagnesemiaPTCTCAE E12336 Grade 3 Hypomagnesemia Grade 3 Hyponatremia NCI<130 - 120 mmol/L Grade 3 HyponatremiaPTCTCAE E12341 Grade 3 Hyponatremia Grade 3 Hypoparathyroidism NCISevere symptoms; medical intervention or hospitalization indicated Grade 3 HypoparathyroidismPTCTCAE E10331 Grade 3 Hypoparathyroidism Grade 3 Hypophosphatemia NCI<2.0 - 1.0 mg/dL; <0.6 - 0.3 mmol/L Grade 3 HypophosphatemiaPTCTCAE E12347 Grade 3 Hypophosphatemia Grade 3 Hypotension NCIMedical intervention or hospitalization indicated Grade 3 HypotensionPTCTCAE E13794 Grade 3 Hypotension Grade 3 Hypothermia NCI32 - >28 degrees C; 89.6 - >82.4 degrees F Grade 3 HypothermiaPTCTCAE E11124 Grade 3 Hypothermia Grade 3 Hypothyroidism NCISevere symptoms; limiting self care ADL; hospitalization indicated Grade 3 HypothyroidismPTCTCAE E10337 Grade 3 Hypothyroidism Grade 3 Hypoxia NCIDecreased oxygen saturation at rest (e.g., pulse oximeter <88% or PaO2 <=55 mm Hg) Grade 3 HypoxiaPTCTCAE E13390 Grade 3 Hypoxia Grade 3 INR increased NCI>2.5 x ULN; >2.5 times above baseline if on anticoagulation Grade 3 INR increasedPTCTCAE E12178 Grade 3 INR increased Grade 3 IVth nerve disorder NCISevere symptoms; limiting self care ADL Grade 3 IVth nerve disorderPTCTCAE E12708 Grade 3 IVth nerve disorder Grade 3 Ileal fistula NCISeverely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated Grade 3 Ileal fistulaPTCTCAE E10780 Grade 3 Ileal fistula Grade 3 Ileal hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Ileal hemorrhagePTCTCAE E10786 Grade 3 Ileal hemorrhage Grade 3 Ileal obstruction NCIHospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling Grade 3 Ileal obstructionPTCTCAE E10792 Grade 3 Ileal obstruction Grade 3 Ileal perforation NCISevere symptoms; elective operative intervention indicated Grade 3 Ileal perforationPTCTCAE E10797 Grade 3 Ileal perforation Grade 3 Ileal stenosis NCISeverely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated Grade 3 Ileal stenosisPTCTCAE E10803 Grade 3 Ileal stenosis Grade 3 Ileal ulcer NCISeverely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling Grade 3 Ileal ulcerPTCTCAE E10809 Grade 3 Ileal ulcer Grade 3 Ileus NCISeverely altered GI function; TPN indicated Grade 3 IleusPTCTCAE E10814 Grade 3 Ileus Grade 3 Immune system disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Immune system disorders - Other, specifyPTCTCAE E11273 Grade 3 Immune system disorders - Other, specify Grade 3 Infections and infestations - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Infections and infestations - Other, specifyPTCTCAE E11418 Grade 3 Infections and infestations - Other, specify Grade 3 Infective myositis NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Infective myositisPTCTCAE E11423 Grade 3 Infective myositis Grade 3 Infusion related reaction NCIProlonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae Grade 3 Infusion related reactionPTCTCAE E11130 Grade 3 Infusion related reaction Grade 3 Infusion site extravasation NCIUlceration or necrosis; severe tissue damage; operative intervention indicated Grade 3 Infusion site extravasationPTCTCAE E11135 Grade 3 Infusion site extravasation Grade 3 Injection site reaction NCIUlceration or necrosis; severe tissue damage; operative intervention indicated Grade 3 Injection site reactionPTCTCAE E11141 Grade 3 Injection site reaction Grade 3 Injury, poisoning and procedural complications - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Injury, poisoning and procedural complications - Other, specifyPTCTCAE E11750 Grade 3 Injury, poisoning and procedural complications - Other, specify Grade 3 Injury to carotid artery NCISevere symptoms; limiting self care ADL (e.g., transient cerebral ischemia); repair or revision indicated Grade 3 Injury to carotid arteryPTCTCAE E11731 Grade 3 Injury to carotid artery Grade 3 Injury to jugular vein NCISymptomatic limiting self care ADL; disabling; repair or revision indicated Grade 3 Injury to jugular veinPTCTCAE E11738 Grade 3 Injury to jugular vein Grade 3 Injury to superior vena cava NCISevere symptoms; limiting self care ADL; disabling; repair or revision indicated Grade 3 Injury to superior vena cavaPTCTCAE E11744 Grade 3 Injury to superior vena cava Grade 3 Insomnia NCISevere difficulty in falling asleep, staying asleep or waking up early Grade 3 InsomniaPTCTCAE E12928 Grade 3 Insomnia Grade 3 Intestinal stoma leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Intestinal stoma leakPTCTCAE E11756 Grade 3 Intestinal stoma leak Grade 3 Intestinal stoma obstruction NCISevere symptoms; IV fluids, tube feeding, or TPN indicated >=24 hrs; elective operative intervention indicated Grade 3 Intestinal stoma obstructionPTCTCAE E11761 Grade 3 Intestinal stoma obstruction Grade 3 Intestinal stoma site bleeding NCISevere bleeding; transfusion indicated; radiologic or endoscopic intervention indicated Grade 3 Intestinal stoma site bleedingPTCTCAE E11767 Grade 3 Intestinal stoma site bleeding Grade 3 Intra-abdominal hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Intra-abdominal hemorrhagePTCTCAE E10819 Grade 3 Intra-abdominal hemorrhage Grade 3 Intracranial hemorrhage NCIVentriculostomy, ICP monitoring, intraventricular thrombolysis, or operative intervention indicated Grade 3 Intracranial hemorrhagePTCTCAE E12699 Grade 3 Intracranial hemorrhage Grade 3 Intraoperative arterial injury NCIComplete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative arterial injuryPTCTCAE E11773 Grade 3 Intraoperative arterial injury Grade 3 Intraoperative breast injury NCIComplete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative breast injuryPTCTCAE E11779 Grade 3 Intraoperative breast injury Grade 3 Intraoperative cardiac injury NCIPrimary repair of injured organ/structure indicated Grade 3 Intraoperative cardiac injuryPTCTCAE E11783 Grade 3 Intraoperative cardiac injury Grade 3 Intraoperative ear injury NCIComplete resection of injured organ/structure indicated; disabling (e.g., impaired hearing; impaired balance) Grade 3 Intraoperative ear injuryPTCTCAE E11789 Grade 3 Intraoperative ear injury Grade 3 Intraoperative endocrine injury NCIComplete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative endocrine injuryPTCTCAE E11795 Grade 3 Intraoperative endocrine injury Grade 3 Intraoperative gastrointestinal injury NCIComplete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative gastrointestinal injuryPTCTCAE E11801 Grade 3 Intraoperative gastrointestinal injury Grade 3 Intraoperative head and neck injury NCIComplete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative head and neck injuryPTCTCAE E11807 Grade 3 Intraoperative head and neck injury Grade 3 Intraoperative hemorrhage NCIPostoperative radiologic, endoscopic, or operative intervention indicated Grade 3 Intraoperative hemorrhagePTCTCAE E11811 Grade 3 Intraoperative hemorrhage Grade 3 Intraoperative hepatobiliary injury NCIComplete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative hepatobiliary injuryPTCTCAE E11817 Grade 3 Intraoperative hepatobiliary injury Grade 3 Intraoperative musculoskeletal injury NCIComplete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative musculoskeletal injuryPTCTCAE E11823 Grade 3 Intraoperative musculoskeletal injury Grade 3 Intraoperative neurological injury NCIComplete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative neurological injuryPTCTCAE E11829 Grade 3 Intraoperative neurological injury Grade 3 Intraoperative ocular injury NCIComplete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative ocular injuryPTCTCAE E11835 Grade 3 Intraoperative ocular injury Grade 3 Intraoperative renal injury NCIComplete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative renal injuryPTCTCAE E11841 Grade 3 Intraoperative renal injury Grade 3 Intraoperative reproductive tract injury NCIComplete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative reproductive tract injuryPTCTCAE E11847 Grade 3 Intraoperative reproductive tract injury Grade 3 Intraoperative respiratory injury NCIComplete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative respiratory injuryPTCTCAE E11853 Grade 3 Intraoperative respiratory injury Grade 3 Intraoperative skin injury NCIComplete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative skin injuryPTCTCAE E11859 Grade 3 Intraoperative skin injury Grade 3 Intraoperative splenic injury NCIResection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative splenic injuryPTCTCAE E11864 Grade 3 Intraoperative splenic injury Grade 3 Intraoperative urinary injury NCIComplete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative urinary injuryPTCTCAE E11870 Grade 3 Intraoperative urinary injury Grade 3 Intraoperative venous injury NCIComplete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 Intraoperative venous injuryPTCTCAE E11876 Grade 3 Intraoperative venous injury Grade 3 Investigations - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Investigations - Other, specifyPTCTCAE E12182 Grade 3 Investigations - Other, specify Grade 3 Iron overload NCISevere symptoms; intervention indicated Grade 3 Iron overloadPTCTCAE E12352 Grade 3 Iron overload Grade 3 Irregular menstruation NCIPersistent amenorrhea for more than 6 months Grade 3 Irregular menstruationPTCTCAE E13128 Grade 3 Irregular menstruation Grade 3 Irritability NCISevere abnormal or excessive response; limiting self care ADL; inconsolable Grade 3 IrritabilityPTCTCAE E11147 Grade 3 Irritability Grade 3 Jejunal fistula NCISeverely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated Grade 3 Jejunal fistulaPTCTCAE E10825 Grade 3 Jejunal fistula Grade 3 Jejunal hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Jejunal hemorrhagePTCTCAE E10831 Grade 3 Jejunal hemorrhage Grade 3 Jejunal obstruction NCIHospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling Grade 3 Jejunal obstructionPTCTCAE E10837 Grade 3 Jejunal obstruction Grade 3 Jejunal perforation NCISevere symptoms; elective operative intervention indicated Grade 3 Jejunal perforationPTCTCAE E10842 Grade 3 Jejunal perforation Grade 3 Jejunal stenosis NCISeverely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated Grade 3 Jejunal stenosisPTCTCAE E10848 Grade 3 Jejunal stenosis Grade 3 Jejunal ulcer NCISeverely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling Grade 3 Jejunal ulcerPTCTCAE E10854 Grade 3 Jejunal ulcer Grade 3 Joint effusion NCISevere symptoms; limiting self care ADL; elective operative intervention indicated; disabling Grade 3 Joint effusionPTCTCAE E12434 Grade 3 Joint effusion Grade 3 Joint infection NCIArthroscopic intervention indicated (e.g., drainage) or arthrotomy (e.g., open surgical drainage) Grade 3 Joint infectionPTCTCAE E11428 Grade 3 Joint infection Grade 3 Joint range of motion decreased NCI>50% decrease in ROM; limiting self care ADL; disabling Grade 3 Joint range of motion decreasedPTCTCAE E12438 Grade 3 Joint range of motion decreased Grade 3 Joint range of motion decreased cervical spine NCIAnkylosed/fused over multiple segments with no C-spine rotation Grade 3 Joint range of motion decreased cervical spinePTCTCAE E12442 Grade 3 Joint range of motion decreased cervical spine Grade 3 Joint range of motion decreased lumbar spine NCI<50% lumbar spine flexion; associated with symptoms of ankylosis or fused over multiple segments with no L-spine flexion (e.g., unable to reach to floor to pick up a very light object) Grade 3 Joint range of motion decreased lumbar spinePTCTCAE E12446 Grade 3 Joint range of motion decreased lumbar spine Grade 3 Keratitis NCIDecline in vision (worse than 20/40 but better than 20/200); limiting self care ADL Grade 3 KeratitisPTCTCAE E10399 Grade 3 Keratitis Grade 3 Kidney anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Kidney anastomotic leakPTCTCAE E11882 Grade 3 Kidney anastomotic leak Grade 3 Kidney infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Kidney infectionPTCTCAE E11432 Grade 3 Kidney infection Grade 3 Kyphosis NCISevere accentuation; operative intervention indicated; limiting self care ADL Grade 3 KyphosisPTCTCAE E12450 Grade 3 Kyphosis Grade 3 Large intestinal anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Large intestinal anastomotic leakPTCTCAE E11888 Grade 3 Large intestinal anastomotic leak Grade 3 Laryngeal edema NCIStridor; respiratory distress; hospitalization indicated Grade 3 Laryngeal edemaPTCTCAE E13396 Grade 3 Laryngeal edema Grade 3 Laryngeal fistula NCISevere symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) Grade 3 Laryngeal fistulaPTCTCAE E13402 Grade 3 Laryngeal fistula Grade 3 Laryngeal hemorrhage NCITransfusion, radiologic, endoscopic, or operative intervention indicated (e.g., hemostasis of bleeding site) Grade 3 Laryngeal hemorrhagePTCTCAE E13408 Grade 3 Laryngeal hemorrhage Grade 3 Laryngeal inflammation NCISevere throat pain; endoscopic intervention indicated Grade 3 Laryngeal inflammationPTCTCAE E13414 Grade 3 Laryngeal inflammation Grade 3 Laryngeal mucositis NCISevere pain; severely altered eating/swallowing; medical intervention indicated Grade 3 Laryngeal mucositisPTCTCAE E13418 Grade 3 Laryngeal mucositis Grade 3 Laryngeal obstruction NCILimiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser) Grade 3 Laryngeal obstructionPTCTCAE E13424 Grade 3 Laryngeal obstruction Grade 3 Laryngeal stenosis NCILimiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser) Grade 3 Laryngeal stenosisPTCTCAE E13430 Grade 3 Laryngeal stenosis Grade 3 Laryngitis NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 LaryngitisPTCTCAE E11437 Grade 3 Laryngitis Grade 3 Laryngopharyngeal dysesthesia NCISevere symptoms; dyspnea and swallowing difficulty; limiting self care ADL Grade 3 Laryngopharyngeal dysesthesiaPTCTCAE E13436 Grade 3 Laryngopharyngeal dysesthesia Grade 3 Laryngospasm NCIRecurrent episodes; noninvasive intervention indicated (e.g., breathing technique, pressure point massage) Grade 3 LaryngospasmPTCTCAE E13441 Grade 3 Laryngospasm Grade 3 Left ventricular systolic dysfunction NCISymptomatic due to drop in ejection fraction responsive to intervention Grade 3 Left ventricular systolic dysfunctionPTCTCAE E10131 Grade 3 Left ventricular systolic dysfunction Grade 3 Leukocytosis NCI>100,000/mm3 Grade 3 LeukocytosisPTCTCAE E10049 Grade 3 Leukocytosis Grade 3 Leukoencephalopathy NCISevere symptoms; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving 2/3 or more of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly Grade 3 LeukoencephalopathyPTCTCAE E12715 Grade 3 Leukoencephalopathy Grade 3 Libido increased NCISevere increase in sexual interest leading to dangerous behavior Grade 3 Libido increasedPTCTCAE E12935 Grade 3 Libido increased Grade 3 Lip infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Lip infectionPTCTCAE E11443 Grade 3 Lip infection Grade 3 Lip pain NCISevere pain; limiting self care ADL Grade 3 Lip painPTCTCAE E10860 Grade 3 Lip pain Grade 3 Lipase increased NCI>2.0 - 5.0 x ULN Grade 3 Lipase increasedPTCTCAE E12188 Grade 3 Lipase increased Grade 3 Lipohypertrophy NCICovering >30% BSA and associated tenderness and narcotics or NSAIDs indicated; lipohypertrophy; limiting self care ADL Grade 3 LipohypertrophyPTCTCAE E13660 Grade 3 Lipohypertrophy Grade 3 Localized edema NCISevere localized edema and intervention indicated; limiting self care ADL Grade 3 Localized edemaPTCTCAE E11151 Grade 3 Localized edema Grade 3 Lordosis NCISevere accentuation; operative intervention indicated; limiting self care ADL Grade 3 LordosisPTCTCAE E12454 Grade 3 Lordosis Grade 3 Lower gastrointestinal hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Lower gastrointestinal hemorrhagePTCTCAE E10864 Grade 3 Lower gastrointestinal hemorrhage Grade 3 Lung infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Lung infectionPTCTCAE E11446 Grade 3 Lung infection Grade 3 Lymph gland infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Lymph gland infectionPTCTCAE E11451 Grade 3 Lymph gland infection Grade 3 Lymph leakage NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Lymph leakagePTCTCAE E13799 Grade 3 Lymph leakage Grade 3 Lymph node pain NCISevere pain; limiting self care ADL Grade 3 Lymph node painPTCTCAE E10055 Grade 3 Lymph node pain Grade 3 Lymphedema NCISevere symptoms; limiting self care ADL Grade 3 LymphedemaPTCTCAE E13805 Grade 3 Lymphedema Grade 3 Lymphocele NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 LymphocelePTCTCAE E13809 Grade 3 Lymphocele Grade 3 Lymphocyte count decreased NCI<500 - 200/mm3; <0.5 - 0.2 x 10e9 /L Grade 3 Lymphocyte count decreasedPTCTCAE E12193 Grade 3 Lymphocyte count decreased Grade 3 Lymphocyte count increased NCI>20,000/mm3 Grade 3 Lymphocyte count increasedPTCTCAE E12197 Grade 3 Lymphocyte count increased Grade 3 Malabsorption NCIInability to aliment adequately; TPN indicated Grade 3 MalabsorptionPTCTCAE E10869 Grade 3 Malabsorption Grade 3 Mania NCISevere manic symptoms (e.g., hypomania; major sexual or financial indiscretions); hospitalization not indicated Grade 3 ManiaPTCTCAE E12939 Grade 3 Mania Grade 3 Mediastinal hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated (e.g., hemostasis of bleeding site) Grade 3 Mediastinal hemorrhagePTCTCAE E13447 Grade 3 Mediastinal hemorrhage Grade 3 Mediastinal infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Mediastinal infectionPTCTCAE E11455 Grade 3 Mediastinal infection Grade 3 Memory impairment NCISevere memory impairment; limiting self care ADL Grade 3 Memory impairmentPTCTCAE E12721 Grade 3 Memory impairment Grade 3 Meningismus NCISevere symptoms; limiting self care ADL Grade 3 MeningismusPTCTCAE E12725 Grade 3 Meningismus Grade 3 Meningitis NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated; focal neurologic deficit Grade 3 MeningitisPTCTCAE E11459 Grade 3 Meningitis Grade 3 Menopause NCIMenopause occurring before age 40 years of age Grade 3 MenopausePTCTCAE E13753 Grade 3 Menopause Grade 3 Menorrhagia NCISevere; transfusion indicated; surgical intervention indicated (e.g., hysterectomy) Grade 3 MenorrhagiaPTCTCAE E13135 Grade 3 Menorrhagia Grade 3 Metabolism and nutrition disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Metabolism and nutrition disorders - Other, specifyPTCTCAE E12358 Grade 3 Metabolism and nutrition disorders - Other, specify Grade 3 Middle ear inflammation NCIMastoiditis; necrosis of canal soft tissue or bone Grade 3 Middle ear inflammationPTCTCAE E10284 Grade 3 Middle ear inflammation Grade 3 Mitral valve disease NCISymptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention Grade 3 Mitral valve diseasePTCTCAE E10137 Grade 3 Mitral valve disease Grade 3 Mobitz type I NCISymptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) Grade 3 Mobitz type IPTCTCAE E10149 Grade 3 Mobitz type I Grade 3 Mobitz (type) II atrioventricular block NCISymptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) Grade 3 Mobitz (type) II atrioventricular blockPTCTCAE E10143 Grade 3 Mobitz (type) II atrioventricular block Grade 3 Movements involuntary NCISevere symptoms; limiting self care ADL Grade 3 Movements involuntaryPTCTCAE E12731 Grade 3 Movements involuntary Grade 3 Mucosal infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Mucosal infectionPTCTCAE E11465 Grade 3 Mucosal infection Grade 3 Mucositis oral NCISevere pain; interfering with oral intake Grade 3 Mucositis oralPTCTCAE E10875 Grade 3 Mucositis oral Grade 3 Multi-organ failure NCIShock with azotemia and acid-base disturbances; significant coagulation abnormalities Grade 3 Multi-organ failurePTCTCAE E11156 Grade 3 Multi-organ failure Grade 3 Muscle weakness left-sided NCILimiting self care ADL; disabling Grade 3 Muscle weakness left-sidedPTCTCAE E12458 Grade 3 Muscle weakness left-sided Grade 3 Muscle weakness lower limb NCILimiting self care ADL; disabling Grade 3 Muscle weakness lower limbPTCTCAE E12462 Grade 3 Muscle weakness lower limb Grade 3 Muscle weakness right-sided NCILimiting self care ADL; disabling Grade 3 Muscle weakness right-sidedPTCTCAE E12466 Grade 3 Muscle weakness right-sided Grade 3 Muscle weakness trunk NCILimiting self care ADL; disabling Grade 3 Muscle weakness trunkPTCTCAE E12470 Grade 3 Muscle weakness trunk Grade 3 Muscle weakness upper limb NCILimiting self care ADL; disabling Grade 3 Muscle weakness upper limbPTCTCAE E12474 Grade 3 Muscle weakness upper limb Grade 3 Musculoskeletal and connective tissue disorder - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Musculoskeletal and connective tissue disorder - Other, specifyPTCTCAE E12478 Grade 3 Musculoskeletal and connective tissue disorder - Other, specify Grade 3 Musculoskeletal deformity NCISignificant deformity, hypoplasia, or asymmetry, unable to be remediated by prosthesis or covered by clothing; disabling Grade 3 Musculoskeletal deformityPTCTCAE E12484 Grade 3 Musculoskeletal deformity Grade 3 Myalgia NCISevere pain; limiting self care ADL Grade 3 MyalgiaPTCTCAE E12488 Grade 3 Myalgia Grade 3 Myelitis NCISevere weakness or sensory loss; limiting self care ADL Grade 3 MyelitisPTCTCAE E12735 Grade 3 Myelitis Grade 3 Myocardial infarction NCISevere symptoms; cardiac enzymes abnormal; hemodynamically stable; ECG changes consistent with infarction Grade 3 Myocardial infarctionPTCTCAE E10154 Grade 3 Myocardial infarction Grade 3 Myocarditis NCISevere with symptoms at rest or with minimal activity or exertion; intervention indicated Grade 3 MyocarditisPTCTCAE E10160 Grade 3 Myocarditis Grade 3 Myositis NCIPain associated with severe weakness; limiting self care ADL Grade 3 MyositisPTCTCAE E12492 Grade 3 Myositis Grade 3 Nail infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Nail infectionPTCTCAE E11471 Grade 3 Nail infection Grade 3 Nasal congestion NCIAssociated with bloody nasal discharge or epistaxis Grade 3 Nasal congestionPTCTCAE E13453 Grade 3 Nasal congestion Grade 3 Nausea NCIInadequate oral caloric or fluid intake; tube feeding, TPN, or hospitalization indicated Grade 3 NauseaPTCTCAE E10881 Grade 3 Nausea Grade 3 Neck edema NCIGeneralized neck edema (e.g., difficulty in turning neck); limiting self care ADL Grade 3 Neck edemaPTCTCAE E11162 Grade 3 Neck edema Grade 3 Neck pain NCISevere pain; limiting self care ADL Grade 3 Neck painPTCTCAE E12496 Grade 3 Neck pain Grade 3 Neck soft tissue necrosis NCIOperative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) Grade 3 Neck soft tissue necrosisPTCTCAE E12499 Grade 3 Neck soft tissue necrosis Grade 3 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specifyPTCTCAE E12558 Grade 3 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify Grade 3 Nervous system disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Nervous system disorders - Other, specifyPTCTCAE E12741 Grade 3 Nervous system disorders - Other, specify Grade 3 Neuralgia NCISevere pain; limiting self care ADL Grade 3 NeuralgiaPTCTCAE E12747 Grade 3 Neuralgia Grade 3 Neutrophil count decreased NCI<1000 - 500/mm3; <1.0 - 0.5 x 10e9 /L Grade 3 Neutrophil count decreasedPTCTCAE E12201 Grade 3 Neutrophil count decreased Grade 3 Night blindness NCILimiting self care ADL Grade 3 Night blindnessPTCTCAE E10404 Grade 3 Night blindness Grade 3 Non-cardiac chest pain NCISevere pain; limiting self care ADL Grade 3 Non-cardiac chest painPTCTCAE E11166 Grade 3 Non-cardiac chest pain Grade 3 Nystagmus NCISevere symptoms; limiting self care ADL Grade 3 NystagmusPTCTCAE E12750 Grade 3 Nystagmus Grade 3 Obesity NCIBMI 30 - 39.9 kg/m2 Grade 3 ObesityPTCTCAE E12363 Grade 3 Obesity Grade 3 Obstruction gastric NCIHospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling Grade 3 Obstruction gastricPTCTCAE E10885 Grade 3 Obstruction gastric Grade 3 Oculomotor nerve disorder NCISevere symptoms; limiting self care ADL Grade 3 Oculomotor nerve disorderPTCTCAE E12754 Grade 3 Oculomotor nerve disorder Grade 3 Olfactory nerve disorder NCISevere symptoms; limiting self care ADL Grade 3 Olfactory nerve disorderPTCTCAE E12757 Grade 3 Olfactory nerve disorder Grade 3 Oligospermia NCISperm concentration <13 million/mL or motility <32% Grade 3 OligospermiaPTCTCAE E13144 Grade 3 Oligospermia Grade 3 Optic nerve disorder NCILimiting vision in the affected eye (worse than 20/40 but better than 20/200) Grade 3 Optic nerve disorderPTCTCAE E10409 Grade 3 Optic nerve disorder Grade 3 Oral cavity fistula NCISeverely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated Grade 3 Oral cavity fistulaPTCTCAE E10891 Grade 3 Oral cavity fistula Grade 3 Oral dysesthesia NCIDisabling pain; tube feeding or TPN indicated Grade 3 Oral dysesthesiaPTCTCAE E10897 Grade 3 Oral dysesthesia Grade 3 Oral hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Oral hemorrhagePTCTCAE E10901 Grade 3 Oral hemorrhage Grade 3 Oral pain NCISevere pain; limiting self care ADL Grade 3 Oral painPTCTCAE E10907 Grade 3 Oral pain Grade 3 Osteonecrosis of jaw NCISevere symptoms; limiting self care ADL; elective operative intervention indicated Grade 3 Osteonecrosis of jawPTCTCAE E12505 Grade 3 Osteonecrosis of jaw Grade 3 Osteoporosis NCILoss of height >=2 cm; hospitalization indicated; limiting self care ADL Grade 3 OsteoporosisPTCTCAE E12511 Grade 3 Osteoporosis Grade 3 Otitis externa NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Otitis externaPTCTCAE E11474 Grade 3 Otitis externa Grade 3 Otitis media NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Otitis mediaPTCTCAE E11479 Grade 3 Otitis media Grade 3 Ovarian hemorrhage NCISevere bleeding; transfusion indicated; radiologic or endoscopic intervention indicated Grade 3 Ovarian hemorrhagePTCTCAE E13148 Grade 3 Ovarian hemorrhage Grade 3 Ovarian infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Ovarian infectionPTCTCAE E11484 Grade 3 Ovarian infection Grade 3 Ovarian rupture NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Ovarian rupturePTCTCAE E13154 Grade 3 Ovarian rupture Grade 3 Ovulation pain NCISevere pain; limiting self care ADL Grade 3 Ovulation painPTCTCAE E13160 Grade 3 Ovulation pain Grade 3 Pain NCISevere pain; limiting self care ADL Grade 3 PainPTCTCAE E11170 Grade 3 Pain Grade 3 Pain in extremity NCISevere pain; limiting self care ADL Grade 3 Pain in extremityPTCTCAE E12515 Grade 3 Pain in extremity Grade 3 Pain of skin NCISevere pain; limiting self care ADL Grade 3 Pain of skinPTCTCAE E13671 Grade 3 Pain of skin Grade 3 Palmar-plantar erythrodysesthesia syndrome NCISevere skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting self care ADL Grade 3 Palmar-plantar erythrodysesthesia syndromePTCTCAE E13675 Grade 3 Palmar-plantar erythrodysesthesia syndrome Grade 3 Pancreas infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Pancreas infectionPTCTCAE E11488 Grade 3 Pancreas infection Grade 3 Pancreatic anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Pancreatic anastomotic leakPTCTCAE E11894 Grade 3 Pancreatic anastomotic leak Grade 3 Pancreatic duct stenosis NCISeverely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated Grade 3 Pancreatic duct stenosisPTCTCAE E10911 Grade 3 Pancreatic duct stenosis Grade 3 Pancreatic enzymes decreased NCISequelae of absorption deficiency Grade 3 Pancreatic enzymes decreasedPTCTCAE E12206 Grade 3 Pancreatic enzymes decreased Grade 3 Pancreatic fistula NCISeverely altered GI function; tube feeding or TPN or hospitalization indicated; elective operative intervention indicated Grade 3 Pancreatic fistulaPTCTCAE E10917 Grade 3 Pancreatic fistula Grade 3 Pancreatic hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Pancreatic hemorrhagePTCTCAE E10923 Grade 3 Pancreatic hemorrhage Grade 3 Pancreatic necrosis NCITube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Pancreatic necrosisPTCTCAE E10927 Grade 3 Pancreatic necrosis Grade 3 Pancreatitis NCISevere pain; vomiting; medical intervention indicated (e.g., analgesia, nutritional support) Grade 3 PancreatitisPTCTCAE E10932 Grade 3 Pancreatitis Grade 3 Papilledema NCIMarked visual field defect (worse than 20/40 but better than 20/200) Grade 3 PapilledemaPTCTCAE E10414 Grade 3 Papilledema Grade 3 Papulopustular rash NCIPapules and/or pustules covering >30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; limiting self-care ADL; associated with local superinfection with oral antibiotics indicated Grade 3 Papulopustular rashPTCTCAE E11494 Grade 3 Papulopustular rash Grade 3 Paresthesia NCISevere symptoms; limiting self care ADL Grade 3 ParesthesiaPTCTCAE E12761 Grade 3 Paresthesia Grade 3 Paronychia NCISurgical intervention or IV antibiotics indicated; limiting self care ADL Grade 3 ParonychiaPTCTCAE E11500 Grade 3 Paronychia Grade 3 Paroxysmal atrial tachycardia NCIIV medication indicated Grade 3 Paroxysmal atrial tachycardiaPTCTCAE E10169 Grade 3 Paroxysmal atrial tachycardia Grade 3 Pelvic floor muscle weakness NCISevere symptoms; limiting self care ADL Grade 3 Pelvic floor muscle weaknessPTCTCAE E13164 Grade 3 Pelvic floor muscle weakness Grade 3 Pelvic infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Pelvic infectionPTCTCAE E11503 Grade 3 Pelvic infection Grade 3 Pelvic pain NCISevere pain; limiting self care ADL Grade 3 Pelvic painPTCTCAE E13170 Grade 3 Pelvic pain Grade 3 Pelvic soft tissue necrosis NCIOperative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) Grade 3 Pelvic soft tissue necrosisPTCTCAE E12518 Grade 3 Pelvic soft tissue necrosis Grade 3 Penile infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Penile infectionPTCTCAE E11508 Grade 3 Penile infection Grade 3 Penile pain NCISevere pain; limiting self care ADL Grade 3 Penile painPTCTCAE E13174 Grade 3 Penile pain Grade 3 Perforation bile duct NCIRadiologic, endoscopic or elective operative intervention indicated Grade 3 Perforation bile ductPTCTCAE E11235 Grade 3 Perforation bile duct Grade 3 Pericardial effusion NCIEffusion with physiologic consequences Grade 3 Pericardial effusionPTCTCAE E10174 Grade 3 Pericardial effusion Grade 3 Pericarditis NCIPericarditis with physiologic consequences (e.g., pericardial constriction) Grade 3 PericarditisPTCTCAE E10183 Grade 3 Pericarditis Grade 3 Perineal pain NCISevere pain; limiting self care ADL Grade 3 Perineal painPTCTCAE E13178 Grade 3 Perineal pain Grade 3 Periodontal disease NCISpontaneous bleeding; severe bone loss with or without tooth loss; osteonecrosis of maxilla or mandible Grade 3 Periodontal diseasePTCTCAE E10938 Grade 3 Periodontal disease Grade 3 Periorbital edema NCIEdema associated with visual disturbance; increased intraocular pressure, glaucoma or retinal hemorrhage; optic neuritis; diuretics indicated; operative intervention indicated Grade 3 Periorbital edemaPTCTCAE E13679 Grade 3 Periorbital edema Grade 3 Periorbital infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Periorbital infectionPTCTCAE E11513 Grade 3 Periorbital infection Grade 3 Peripheral ischemia NCIRecurring or prolonged (>=24 hrs) and/or invasive intervention indicated Grade 3 Peripheral ischemiaPTCTCAE E13812 Grade 3 Peripheral ischemia Grade 3 Peripheral motor neuropathy NCISevere symptoms; limiting self care ADL; assistive device indicated Grade 3 Peripheral motor neuropathyPTCTCAE E12765 Grade 3 Peripheral motor neuropathy Grade 3 Peripheral nerve infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Peripheral nerve infectionPTCTCAE E11518 Grade 3 Peripheral nerve infection Grade 3 Peripheral sensory neuropathy NCISevere symptoms; limiting self care ADL Grade 3 Peripheral sensory neuropathyPTCTCAE E12771 Grade 3 Peripheral sensory neuropathy Grade 3 Peritoneal infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Peritoneal infectionPTCTCAE E11522 Grade 3 Peritoneal infection Grade 3 Peritoneal necrosis NCITube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Peritoneal necrosisPTCTCAE E10940 Grade 3 Peritoneal necrosis Grade 3 Personality change NCISevere personality change; hospitalization not indicated Grade 3 Personality changePTCTCAE E12945 Grade 3 Personality change Grade 3 Phantom pain NCISevere pain; limiting self care ADL Grade 3 Phantom painPTCTCAE E12777 Grade 3 Phantom pain Grade 3 Pharyngeal anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Pharyngeal anastomotic leakPTCTCAE E11900 Grade 3 Pharyngeal anastomotic leak Grade 3 Pharyngeal fistula NCISevere symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) Grade 3 Pharyngeal fistulaPTCTCAE E13457 Grade 3 Pharyngeal fistula Grade 3 Pharyngeal hemorrhage NCITransfusion, radiologic, endoscopic, or operative intervention indicated (e.g., hemostasis of bleeding site) Grade 3 Pharyngeal hemorrhagePTCTCAE E13463 Grade 3 Pharyngeal hemorrhage Grade 3 Pharyngeal mucositis NCISevere pain; unable to adequately aliment or hydrate orally; limiting self care ADL Grade 3 Pharyngeal mucositisPTCTCAE E13469 Grade 3 Pharyngeal mucositis Grade 3 Pharyngeal necrosis NCIInability to aliment adequately by GI tract; tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Pharyngeal necrosisPTCTCAE E13473 Grade 3 Pharyngeal necrosis Grade 3 Pharyngeal stenosis NCILimiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser) Grade 3 Pharyngeal stenosisPTCTCAE E13479 Grade 3 Pharyngeal stenosis Grade 3 Pharyngitis NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 PharyngitisPTCTCAE E11527 Grade 3 Pharyngitis Grade 3 Pharyngolaryngeal pain NCISevere pain; limiting self care ADL Grade 3 Pharyngolaryngeal painPTCTCAE E13485 Grade 3 Pharyngolaryngeal pain Grade 3 Phlebitis infective NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Phlebitis infectivePTCTCAE E11532 Grade 3 Phlebitis infective Grade 3 Photophobia NCILimiting self care ADL Grade 3 PhotophobiaPTCTCAE E10419 Grade 3 Photophobia Grade 3 Photosensitivity NCIErythema covering >30% BSA and erythema with blistering; photosensitivity; oral corticosteroid therapy indicated; pain control indicated (e.g., narcotics or NSAIDs) Grade 3 PhotosensitivityPTCTCAE E13683 Grade 3 Photosensitivity Grade 3 Platelet count decreased NCI<50,000 - 25,000/mm3; <50.0 - 25.0 x 10e9 /L Grade 3 Platelet count decreasedPTCTCAE E12210 Grade 3 Platelet count decreased Grade 3 Pleural effusion NCISymptomatic with respiratory distress and hypoxia; surgical intervention including chest tube or pleurodesis indicated Grade 3 Pleural effusionPTCTCAE E13489 Grade 3 Pleural effusion Grade 3 Pleural hemorrhage NCI>1000 ml of blood evacuated; persistent bleeding (150-200 ml/hr for 2 - 4 hr); persistent transfusion indicated; elective operative intervention indicated Grade 3 Pleural hemorrhagePTCTCAE E13495 Grade 3 Pleural hemorrhage Grade 3 Pleural infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Pleural infectionPTCTCAE E11537 Grade 3 Pleural infection Grade 3 Pleuritic pain NCISevere pain; limiting self care ADL Grade 3 Pleuritic painPTCTCAE E13501 Grade 3 Pleuritic pain Grade 3 Pneumonitis NCISevere symptoms; limiting self care ADL; oxygen indicated Grade 3 PneumonitisPTCTCAE E13505 Grade 3 Pneumonitis Grade 3 Pneumothorax NCISclerosis and/or operative intervention indicated; hospitalization indicated Grade 3 PneumothoraxPTCTCAE E13511 Grade 3 Pneumothorax Grade 3 Portal hypertension NCIReversal/retrograde portal vein flow; associated with varices and/or ascites Grade 3 Portal hypertensionPTCTCAE E11240 Grade 3 Portal hypertension Grade 3 Portal vein thrombosis NCIMedical intervention indicated Grade 3 Portal vein thrombosisPTCTCAE E11245 Grade 3 Portal vein thrombosis Grade 3 Postoperative hemorrhage NCITransfusion indicated of >=2 units (10 cc/kg for pediatrics) pRBCs beyond protocol specification; urgent radiologic, endoscopic, or operative intervention indicated Grade 3 Postoperative hemorrhagePTCTCAE E11906 Grade 3 Postoperative hemorrhage Grade 3 Postoperative thoracic procedure complication NCIExtubated >72 hrs postoperatively, but before tracheostomy indicated Grade 3 Postoperative thoracic procedure complicationPTCTCAE E11911 Grade 3 Postoperative thoracic procedure complication Grade 3 Pregnancy, puerperium and perinatal conditions - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Pregnancy, puerperium and perinatal conditions - Other, specifyPTCTCAE E12864 Grade 3 Pregnancy, puerperium and perinatal conditions - Other, specify Grade 3 Premature delivery NCIDelivery of a liveborn infant at 24 to 28 weeks gestation Grade 3 Premature deliveryPTCTCAE E12870 Grade 3 Premature delivery Grade 3 Premature menopause NCIPresent Grade 3 Premature menopausePTCTCAE E13180 Grade 3 Premature menopause Grade 3 Proctitis NCISevere symptoms; fecal urgency or stool incontinence; limiting self care ADL Grade 3 ProctitisPTCTCAE E10946 Grade 3 Proctitis Grade 3 Productive cough NCIPersistent or copious production of sputum; limiting self care ADL Grade 3 Productive coughPTCTCAE E13520 Grade 3 Productive cough Grade 3 Prolapse of intestinal stoma NCISevere symptoms; elective operative intervention indicated; limiting self care ADL Grade 3 Prolapse of intestinal stomaPTCTCAE E11917 Grade 3 Prolapse of intestinal stoma Grade 3 Prolapse of urostomy NCIDysfunctional stoma; elective operative intervention or major stomal revision indicated Grade 3 Prolapse of urostomyPTCTCAE E11923 Grade 3 Prolapse of urostomy Grade 3 Prostate infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Prostate infectionPTCTCAE E11542 Grade 3 Prostate infection Grade 3 Prostatic hemorrhage NCISevere bleeding; transfusion indicated; radiologic or endoscopic intervention indicated Grade 3 Prostatic hemorrhagePTCTCAE E13184 Grade 3 Prostatic hemorrhage Grade 3 Prostatic obstruction NCISevere symptoms; elective operative intervention indicated Grade 3 Prostatic obstructionPTCTCAE E13190 Grade 3 Prostatic obstruction Grade 3 Prostatic pain NCISevere pain; limiting self care ADL Grade 3 Prostatic painPTCTCAE E13194 Grade 3 Prostatic pain Grade 3 Proteinuria NCIAdults: urinary protein >=3.5 g/24 hrs; Pediatric: urine P/C >1.9 Grade 3 ProteinuriaPTCTCAE E13011 Grade 3 Proteinuria Grade 3 Pruritus NCIIntense or widespread; constant; limiting self care ADL or sleep; oral corticosteroid or immunosuppressive therapy indicated Grade 3 PruritusPTCTCAE E13689 Grade 3 Pruritus Grade 3 Psychiatric disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; disabling; limiting self care ADL Grade 3 Psychiatric disorders - Other, specifyPTCTCAE E12951 Grade 3 Psychiatric disorders - Other, specify Grade 3 Psychosis NCISevere psychotic symptoms (e.g., paranoid; extreme disorganization); hospitalization not indicated Grade 3 PsychosisPTCTCAE E12957 Grade 3 Psychosis Grade 3 Pulmonary edema NCISevere dyspnea or dyspnea at rest; oxygen indicated; limiting self care ADL Grade 3 Pulmonary edemaPTCTCAE E13524 Grade 3 Pulmonary edema Grade 3 Pulmonary fibrosis NCISevere hypoxemia; evidence of right-sided heart failure; radiographic pulmonary fibrosis >50 - 75% Grade 3 Pulmonary fibrosisPTCTCAE E13530 Grade 3 Pulmonary fibrosis Grade 3 Pulmonary fistula NCILimiting self care ADL; endoscopic stenting or operative intervention indicated Grade 3 Pulmonary fistulaPTCTCAE E13536 Grade 3 Pulmonary fistula Grade 3 Pulmonary hypertension NCISevere symptoms, associated with hypoxemia, right heart failure; oxygen indicated Grade 3 Pulmonary hypertensionPTCTCAE E13542 Grade 3 Pulmonary hypertension Grade 3 Pulmonary valve disease NCISymptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention Grade 3 Pulmonary valve diseasePTCTCAE E10189 Grade 3 Pulmonary valve disease Grade 3 Purpura NCICombined area of lesions covering >30% BSA; spontaneous bleeding Grade 3 PurpuraPTCTCAE E13693 Grade 3 Purpura Grade 3 Pyramidal tract syndrome NCISevere symptoms; limiting self care ADL Grade 3 Pyramidal tract syndromePTCTCAE E12783 Grade 3 Pyramidal tract syndrome Grade 3 Radiation recall reaction (dermatologic) NCIMoist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion Grade 3 Radiation recall reaction (dermatologic)PTCTCAE E11929 Grade 3 Radiation recall reaction (dermatologic) Grade 3 Radiculitis NCISevere symptoms; limiting self care ADL Grade 3 RadiculitisPTCTCAE E12789 Grade 3 Radiculitis Grade 3 Rash acneiform NCIPapules and/or pustules covering >30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; limiting self care ADL; associated with local superinfection with oral antibiotics indicated Grade 3 Rash acneiformPTCTCAE E13697 Grade 3 Rash acneiform Grade 3 Rash maculo-papular NCIMacules/papules covering >30% BSA with or without associated symptoms; limiting self care ADL Grade 3 Rash maculo-papularPTCTCAE E13703 Grade 3 Rash maculo-papular Grade 3 Rash pustular NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Rash pustularPTCTCAE E11547 Grade 3 Rash pustular Grade 3 Rectal anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Rectal anastomotic leakPTCTCAE E11935 Grade 3 Rectal anastomotic leak Grade 3 Rectal fistula NCISeverely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated Grade 3 Rectal fistulaPTCTCAE E10952 Grade 3 Rectal fistula Grade 3 Rectal hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Rectal hemorrhagePTCTCAE E10958 Grade 3 Rectal hemorrhage Grade 3 Rectal mucositis NCISevere symptoms; limiting self care ADL Grade 3 Rectal mucositisPTCTCAE E10964 Grade 3 Rectal mucositis Grade 3 Rectal necrosis NCITube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Rectal necrosisPTCTCAE E10968 Grade 3 Rectal necrosis Grade 3 Rectal obstruction NCIHospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling Grade 3 Rectal obstructionPTCTCAE E10974 Grade 3 Rectal obstruction Grade 3 Rectal pain NCISevere pain; limiting self care ADL Grade 3 Rectal painPTCTCAE E10980 Grade 3 Rectal pain Grade 3 Rectal perforation NCISevere symptoms; elective operative intervention indicated Grade 3 Rectal perforationPTCTCAE E10983 Grade 3 Rectal perforation Grade 3 Rectal stenosis NCISeverely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated Grade 3 Rectal stenosisPTCTCAE E10989 Grade 3 Rectal stenosis Grade 3 Rectal ulcer NCISeverely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling Grade 3 Rectal ulcerPTCTCAE E10995 Grade 3 Rectal ulcer Grade 3 Recurrent laryngeal nerve palsy NCISevere symptoms; medical intervention indicated (e.g., thyroplasty, vocal cord injection) Grade 3 Recurrent laryngeal nerve palsyPTCTCAE E12795 Grade 3 Recurrent laryngeal nerve palsy Grade 3 Renal and urinary disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Renal and urinary disorders - Other, specifyPTCTCAE E13015 Grade 3 Renal and urinary disorders - Other, specify Grade 3 Renal calculi NCIHospitalization indicated; IV intervention (e.g., analgesics, antiemetics); elective endoscopic or radiologic intervention indicated Grade 3 Renal calculiPTCTCAE E13021 Grade 3 Renal calculi Grade 3 Renal colic NCIHospitalization indicated; limiting self care ADL Grade 3 Renal colicPTCTCAE E13027 Grade 3 Renal colic Grade 3 Renal hemorrhage NCITransfusion, radiation, or hospitalization indicated; elective radiologic, endoscopic or operative intervention indicated Grade 3 Renal hemorrhagePTCTCAE E13031 Grade 3 Renal hemorrhage Grade 3 Reproductive system and breast disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Reproductive system and breast disorders - Other, specifyPTCTCAE E13198 Grade 3 Reproductive system and breast disorders - Other, specify Grade 3 Respiratory, thoracic and mediastinal disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Respiratory, thoracic and mediastinal disorders - Other, specifyPTCTCAE E13551 Grade 3 Respiratory, thoracic and mediastinal disorders - Other, specify Grade 3 Restlessness NCISevere symptoms; limiting self care ADL Grade 3 RestlessnessPTCTCAE E12963 Grade 3 Restlessness Grade 3 Restrictive cardiomyopathy NCISymptomatic heart failure or other cardiac symptoms, responsive to intervention Grade 3 Restrictive cardiomyopathyPTCTCAE E10193 Grade 3 Restrictive cardiomyopathy Grade 3 Retinal detachment NCIRhegmatogenous or exudative detachment; operative intervention indicated; decline in vision (worse than 20/40 but better than 20/200) Grade 3 Retinal detachmentPTCTCAE E10423 Grade 3 Retinal detachment Grade 3 Retinal tear NCIVitroretinal surgical repair indicated Grade 3 Retinal tearPTCTCAE E10427 Grade 3 Retinal tear Grade 3 Retinal vascular disorder NCIIntravitreal medication; operative intervention indicated Grade 3 Retinal vascular disorderPTCTCAE E10431 Grade 3 Retinal vascular disorder Grade 3 Retinoic acid syndrome NCISevere symptoms; hospitalization indicated Grade 3 Retinoic acid syndromePTCTCAE E13557 Grade 3 Retinoic acid syndrome Grade 3 Retinopathy NCISymptomatic with marked decrease in visual acuity (worse than 20/40); disabling; limiting self care ADL Grade 3 RetinopathyPTCTCAE E10435 Grade 3 Retinopathy Grade 3 Retroperitoneal hemorrhage NCITransfusion, medical, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Retroperitoneal hemorrhagePTCTCAE E11000 Grade 3 Retroperitoneal hemorrhage Grade 3 Reversible posterior leukoencephalopathy syndrome NCISevere symptoms; very abnormal imaging studies; limiting self care ADL Grade 3 Reversible posterior leukoencephalopathy syndromePTCTCAE E12801 Grade 3 Reversible posterior leukoencephalopathy syndrome Grade 3 Right ventricular dysfunction NCISevere symptoms, associated with hypoxemia, right heart failure; oxygen indicated Grade 3 Right ventricular dysfunctionPTCTCAE E10199 Grade 3 Right ventricular dysfunction Grade 3 Salivary duct inflammation NCIAcute salivary gland necrosis; severe secretion-induced symptoms (e.g., thick saliva/oral secretions or gagging); tube feeding or TPN indicated; limiting self care ADL; disabling Grade 3 Salivary duct inflammationPTCTCAE E11006 Grade 3 Salivary duct inflammation Grade 3 Salivary gland fistula NCISeverely altered GI function; hospitalization indicated; elective operative intervention indicated Grade 3 Salivary gland fistulaPTCTCAE E11012 Grade 3 Salivary gland fistula Grade 3 Salivary gland infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Salivary gland infectionPTCTCAE E11552 Grade 3 Salivary gland infection Grade 3 Scalp pain NCISevere pain; limiting self care ADL Grade 3 Scalp painPTCTCAE E13707 Grade 3 Scalp pain Grade 3 Scleral disorder NCISymptomatic, limiting self care ADL; marked decrease in visual acuity (worse than 20/40) Grade 3 Scleral disorderPTCTCAE E10440 Grade 3 Scleral disorder Grade 3 Scoliosis NCI>45 degrees; scapular prominence in forward flexion; operative intervention indicated; limiting self care ADL; disabling Grade 3 ScoliosisPTCTCAE E12524 Grade 3 Scoliosis Grade 3 Scrotal infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Scrotal infectionPTCTCAE E11557 Grade 3 Scrotal infection Grade 3 Scrotal pain NCISevere pain; limiting self care ADL Grade 3 Scrotal painPTCTCAE E13204 Grade 3 Scrotal pain Grade 3 Seizure NCIMultiple seizures despite medical intervention Grade 3 SeizurePTCTCAE E12807 Grade 3 Seizure Grade 3 Seroma NCISymptomatic, elective radiologic or operative intervention indicated Grade 3 SeromaPTCTCAE E11941 Grade 3 Seroma Grade 3 Serum amylase increased NCI>2.0 - 5.0 x ULN Grade 3 Serum amylase increasedPTCTCAE E12215 Grade 3 Serum amylase increased Grade 3 Serum sickness NCISevere arthralgia or arthritis; extensive rash; steroids or IV fluids indicated Grade 3 Serum sicknessPTCTCAE E11279 Grade 3 Serum sickness Grade 3 Sick sinus syndrome NCISevere, medically significant; medical intervention indicated Grade 3 Sick sinus syndromePTCTCAE E10205 Grade 3 Sick sinus syndrome Grade 3 Sinus bradycardia NCISevere, medically significant, medical intervention indicated Grade 3 Sinus bradycardiaPTCTCAE E10211 Grade 3 Sinus bradycardia Grade 3 Sinus disorder NCIStenosis with significant nasal obstruction; limiting self care ADL Grade 3 Sinus disorderPTCTCAE E13563 Grade 3 Sinus disorder Grade 3 Sinus pain NCISevere pain; limiting self care ADL Grade 3 Sinus painPTCTCAE E12813 Grade 3 Sinus pain Grade 3 Sinus tachycardia NCIUrgent medical intervention indicated Grade 3 Sinus tachycardiaPTCTCAE E10217 Grade 3 Sinus tachycardia Grade 3 Sinusitis NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 SinusitisPTCTCAE E11565 Grade 3 Sinusitis Grade 3 Skin and subcutaneous tissue disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Skin and subcutaneous tissue disorders - Other, specifyPTCTCAE E13711 Grade 3 Skin and subcutaneous tissue disorders - Other, specify Grade 3 Skin atrophy NCICovering >30% BSA; associated with ulceration Grade 3 Skin atrophyPTCTCAE E13717 Grade 3 Skin atrophy Grade 3 Skin induration NCISevere induration, unable to slide or pinch skin; limiting joint movement or orifice (e.g., mouth, anus); limiting self care ADL Grade 3 Skin indurationPTCTCAE E13727 Grade 3 Skin induration Grade 3 Skin infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Skin infectionPTCTCAE E11571 Grade 3 Skin infection Grade 3 Skin ulceration NCICombined area of ulcers >2 cm; full-thickness skin loss involving damage to or necrosis of subcutaneous tissue that may extend down to fascia Grade 3 Skin ulcerationPTCTCAE E13733 Grade 3 Skin ulceration Grade 3 Sleep apnea NCIOxygen desaturation; associated with hypertension; medical intervention indicated; limiting self care ADL Grade 3 Sleep apneaPTCTCAE E13569 Grade 3 Sleep apnea Grade 3 Small intestinal anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Small intestinal anastomotic leakPTCTCAE E11945 Grade 3 Small intestinal anastomotic leak Grade 3 Small intestinal mucositis NCISevere pain; interfering with oral intake; tube feeding, TPN or hospitalization indicated; limiting self care ADL Grade 3 Small intestinal mucositisPTCTCAE E11018 Grade 3 Small intestinal mucositis Grade 3 Small intestinal obstruction NCIHospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling Grade 3 Small intestinal obstructionPTCTCAE E11024 Grade 3 Small intestinal obstruction Grade 3 Small intestinal perforation NCISevere symptoms; elective operative intervention indicated Grade 3 Small intestinal perforationPTCTCAE E11029 Grade 3 Small intestinal perforation Grade 3 Small intestinal stenosis NCISymptomatic and severely altered GI function; tube feeding, TPN or hospitalization indicated; non-emergent operative intervention indicated Grade 3 Small intestinal stenosisPTCTCAE E11035 Grade 3 Small intestinal stenosis Grade 3 Small intestine infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Small intestine infectionPTCTCAE E11576 Grade 3 Small intestine infection Grade 3 Small intestine ulcer NCISeverely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care ADL; disabling Grade 3 Small intestine ulcerPTCTCAE E11041 Grade 3 Small intestine ulcer Grade 3 Social circumstances - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Social circumstances - Other, specifyPTCTCAE E13757 Grade 3 Social circumstances - Other, specify Grade 3 Soft tissue infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Soft tissue infectionPTCTCAE E11581 Grade 3 Soft tissue infection Grade 3 Soft tissue necrosis lower limb NCIOperative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) Grade 3 Soft tissue necrosis lower limbPTCTCAE E12527 Grade 3 Soft tissue necrosis lower limb Grade 3 Soft tissue necrosis upper limb NCIOperative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) Grade 3 Soft tissue necrosis upper limbPTCTCAE E12532 Grade 3 Soft tissue necrosis upper limb Grade 3 Somnolence NCIObtundation or stupor Grade 3 SomnolencePTCTCAE E12817 Grade 3 Somnolence Grade 3 Sore throat NCISevere pain; limiting self care ADL; limiting ability to swallow Grade 3 Sore throatPTCTCAE E13578 Grade 3 Sore throat Grade 3 Spasticity NCISevere increase in muscle tone and increase in resistance through range of motion Grade 3 SpasticityPTCTCAE E12823 Grade 3 Spasticity Grade 3 Spermatic cord anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Spermatic cord anastomotic leakPTCTCAE E11951 Grade 3 Spermatic cord anastomotic leak Grade 3 Spermatic cord hemorrhage NCISevere bleeding; transfusion indicated; radiologic or endoscopic intervention indicated Grade 3 Spermatic cord hemorrhagePTCTCAE E13208 Grade 3 Spermatic cord hemorrhage Grade 3 Spermatic cord obstruction NCISevere symptoms; elective operative intervention indicated Grade 3 Spermatic cord obstructionPTCTCAE E13214 Grade 3 Spermatic cord obstruction Grade 3 Spinal fracture NCISevere back pain; hospitalization or intervention indicated for pain control (e.g., vertebroplasty); limiting self care ADL; disability Grade 3 Spinal fracturePTCTCAE E11957 Grade 3 Spinal fracture Grade 3 Splenic infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Splenic infectionPTCTCAE E11585 Grade 3 Splenic infection Grade 3 Stenosis of gastrointestinal stoma NCISeverely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated Grade 3 Stenosis of gastrointestinal stomaPTCTCAE E11962 Grade 3 Stenosis of gastrointestinal stoma Grade 3 Stevens-Johnson syndrome NCISkin sloughing covering <10% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment) Grade 3 Stevens-Johnson syndromePTCTCAE E13737 Grade 3 Stevens-Johnson syndrome Grade 3 Stoma site infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Stoma site infectionPTCTCAE E11591 Grade 3 Stoma site infection Grade 3 Stomach pain NCISevere pain; limiting self care ADL Grade 3 Stomach painPTCTCAE E11047 Grade 3 Stomach pain Grade 3 Stomal ulcer NCISevere symptoms; elective operative intervention indicated Grade 3 Stomal ulcerPTCTCAE E11968 Grade 3 Stomal ulcer Grade 3 Stridor NCIRespiratory distress limiting self care ADL; medical intervention indicated Grade 3 StridorPTCTCAE E13580 Grade 3 Stridor Grade 3 Stroke NCISevere neurologic deficit Grade 3 StrokePTCTCAE E12829 Grade 3 Stroke Grade 3 Suicidal ideation NCISpecific plan to commit suicide without serious intent to die which may not require hospitalization Grade 3 Suicidal ideationPTCTCAE E12967 Grade 3 Suicidal ideation Grade 3 Suicide attempt NCISuicide attempt or gesture without intent to die which may not require hospitalization Grade 3 Suicide attemptPTCTCAE E12970 Grade 3 Suicide attempt Grade 3 Superficial soft tissue fibrosis NCISevere induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL Grade 3 Superficial soft tissue fibrosisPTCTCAE E12538 Grade 3 Superficial soft tissue fibrosis Grade 3 Superior vena cava syndrome NCISevere symptoms; multi-modality intervention indicated (e.g., anticoagulation, chemotherapy, radiation, stenting) Grade 3 Superior vena cava syndromePTCTCAE E13822 Grade 3 Superior vena cava syndrome Grade 3 Supraventricular tachycardia NCIMedical intervention indicated Grade 3 Supraventricular tachycardiaPTCTCAE E10221 Grade 3 Supraventricular tachycardia Grade 3 Surgical and medical procedures - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Surgical and medical procedures - Other, specifyPTCTCAE E13763 Grade 3 Surgical and medical procedures - Other, specify Grade 3 Syncope NCIFainting; orthostatic collapse Grade 3 SyncopePTCTCAE E12833 Grade 3 Syncope Grade 3 Testicular disorder NCISevere symptoms; interfering with urination or sexual function; limiting self care ADL; intervention indicated Grade 3 Testicular disorderPTCTCAE E13218 Grade 3 Testicular disorder Grade 3 Testicular hemorrhage NCISevere bleeding; transfusion indicated; radiologic or endoscopic intervention indicated Grade 3 Testicular hemorrhagePTCTCAE E13224 Grade 3 Testicular hemorrhage Grade 3 Testicular pain NCISevere pain; limiting self care ADL Grade 3 Testicular painPTCTCAE E13230 Grade 3 Testicular pain Grade 3 Thromboembolic event NCIThrombosis (e.g., uncomplicated pulmonary embolism [venous], non-embolic cardiac mural [arterial] thrombus), medical intervention indicated Grade 3 Thromboembolic eventPTCTCAE E13828 Grade 3 Thromboembolic event Grade 3 Thrombotic thrombocytopenic purpura NCILaboratory findings with clinical consequences (e.g., renal insufficiency, petechiae) Grade 3 Thrombotic thrombocytopenic purpuraPTCTCAE E10063 Grade 3 Thrombotic thrombocytopenic purpura Grade 3 Tinnitus NCISevere symptoms; limiting self care ADL Grade 3 TinnitusPTCTCAE E10290 Grade 3 Tinnitus Grade 3 Tooth development disorder NCIMaldevelopment with impairment not surgically correctable; disabling Grade 3 Tooth development disorderPTCTCAE E11051 Grade 3 Tooth development disorder Grade 3 Tooth infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Tooth infectionPTCTCAE E11596 Grade 3 Tooth infection Grade 3 Toothache NCISevere pain; limiting self care ADL Grade 3 ToothachePTCTCAE E11057 Grade 3 Toothache Grade 3 Tracheal fistula NCISevere symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) Grade 3 Tracheal fistulaPTCTCAE E13586 Grade 3 Tracheal fistula Grade 3 Tracheal hemorrhage NCISevere bleeding; transfusion indicated; radiologic or endoscopic intervention indicated Grade 3 Tracheal hemorrhagePTCTCAE E11972 Grade 3 Tracheal hemorrhage Grade 3 Tracheal mucositis NCISevere pain; hemorrhage or respiratory symptoms; limiting self care ADL Grade 3 Tracheal mucositisPTCTCAE E13592 Grade 3 Tracheal mucositis Grade 3 Tracheal obstruction NCIStridor; radiologic or endoscopic intervention indicated (e.g., stent, laser); limiting self care ADL Grade 3 Tracheal obstructionPTCTCAE E11978 Grade 3 Tracheal obstruction Grade 3 Tracheal stenosis NCIStridor or respiratory distress limiting self care ADL; endoscopic intervention indicated (e.g., stent, laser) Grade 3 Tracheal stenosisPTCTCAE E13598 Grade 3 Tracheal stenosis Grade 3 Tracheitis NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 TracheitisPTCTCAE E11601 Grade 3 Tracheitis Grade 3 Tracheostomy site bleeding NCISevere bleeding; transfusion indicated; radiologic or endoscopic intervention indicated Grade 3 Tracheostomy site bleedingPTCTCAE E11984 Grade 3 Tracheostomy site bleeding Grade 3 Treatment related secondary malignancy NCINon life-threatening secondary malignancy Grade 3 Treatment related secondary malignancyPTCTCAE E12562 Grade 3 Treatment related secondary malignancy Grade 3 Tremor NCISevere symptoms; limiting self care ADL Grade 3 TremorPTCTCAE E12840 Grade 3 Tremor Grade 3 Tricuspid valve disease NCISymptomatic; severe regurgitation or stenosis; symptoms controlled with medical intervention Grade 3 Tricuspid valve diseasePTCTCAE E10227 Grade 3 Tricuspid valve disease Grade 3 Trigeminal nerve disorder NCISevere symptoms; limiting self care ADL Grade 3 Trigeminal nerve disorderPTCTCAE E12844 Grade 3 Trigeminal nerve disorder Grade 3 Trismus NCIDecreased ROM with inability to adequately aliment or hydrate orally Grade 3 TrismusPTCTCAE E12544 Grade 3 Trismus Grade 3 Tumor lysis syndrome NCIPresent Grade 3 Tumor lysis syndromePTCTCAE E12366 Grade 3 Tumor lysis syndrome Grade 3 Tumor pain NCISevere pain; limiting self care ADL Grade 3 Tumor painPTCTCAE E12568 Grade 3 Tumor pain Grade 3 Typhlitis NCISymptomatic (e.g., abdominal pain, fever, change in bowel habits with ileus); peritoneal signs Grade 3 TyphlitisPTCTCAE E11059 Grade 3 Typhlitis Grade 3 Unequal limb length NCISevere length discrepancy >5 cm; limiting self care ADL; disabling; operative intervention indicated Grade 3 Unequal limb lengthPTCTCAE E12548 Grade 3 Unequal limb length Grade 3 Unintended pregnancy NCIUnintended pregnancy Grade 3 Unintended pregnancyPTCTCAE E12873 Grade 3 Unintended pregnancy Grade 3 Upper gastrointestinal hemorrhage NCITransfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 Upper gastrointestinal hemorrhagePTCTCAE E11065 Grade 3 Upper gastrointestinal hemorrhage Grade 3 Upper respiratory infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Upper respiratory infectionPTCTCAE E11606 Grade 3 Upper respiratory infection Grade 3 Ureteric anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Ureteric anastomotic leakPTCTCAE E11990 Grade 3 Ureteric anastomotic leak Grade 3 Urethral anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Urethral anastomotic leakPTCTCAE E11996 Grade 3 Urethral anastomotic leak Grade 3 Urethral infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 Urethral infectionPTCTCAE E11611 Grade 3 Urethral infection Grade 3 Urinary fistula NCILimiting self care ADL; elective radiologic, endoscopic or operative intervention indicated; permanent urinary diversion indicated Grade 3 Urinary fistulaPTCTCAE E13036 Grade 3 Urinary fistula Grade 3 Urinary incontinence NCIIntervention indicated (e.g., clamp, collagen injections); operative intervention indicated; limiting self care ADL Grade 3 Urinary incontinencePTCTCAE E13045 Grade 3 Urinary incontinence Grade 3 Urinary retention NCIElective operative or radiologic intervention indicated; substantial loss of affected kidney function or mass Grade 3 Urinary retentionPTCTCAE E13049 Grade 3 Urinary retention Grade 3 Urinary tract infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Urinary tract infectionPTCTCAE E11616 Grade 3 Urinary tract infection Grade 3 Urinary tract obstruction NCISymptomatic and altered organ function (e.g., hydronephrosis, or renal dysfunction); elective radiologic, endoscopic or operative intervention indicated Grade 3 Urinary tract obstructionPTCTCAE E13055 Grade 3 Urinary tract obstruction Grade 3 Urinary tract pain NCISevere pain; limiting self care ADL Grade 3 Urinary tract painPTCTCAE E13061 Grade 3 Urinary tract pain Grade 3 Urine output decreased NCIOliguria (<80 ml in 8 hr) Grade 3 Urine output decreasedPTCTCAE E12218 Grade 3 Urine output decreased Grade 3 Urostomy leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Urostomy leakPTCTCAE E12002 Grade 3 Urostomy leak Grade 3 Urostomy obstruction NCIAltered organ function (e.g., sepsis or hydronephrosis, or renal dysfunction); elective operative intervention indicated Grade 3 Urostomy obstructionPTCTCAE E12008 Grade 3 Urostomy obstruction Grade 3 Urostomy site bleeding NCISevere bleeding; transfusion indicated; radiologic or endoscopic intervention indicated Grade 3 Urostomy site bleedingPTCTCAE E12014 Grade 3 Urostomy site bleeding Grade 3 Urostomy stenosis NCISymptomatic (e.g., hydronephrosis, or renal dysfunction); elective operative intervention indicated Grade 3 Urostomy stenosisPTCTCAE E12019 Grade 3 Urostomy stenosis Grade 3 Urticaria NCIUrticarial lesions covering >30% BSA; IV intervention indicated Grade 3 UrticariaPTCTCAE E13749 Grade 3 Urticaria Grade 3 Uterine anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Uterine anastomotic leakPTCTCAE E12025 Grade 3 Uterine anastomotic leak Grade 3 Uterine fistula NCISevere symptoms; elective operative intervention indicated Grade 3 Uterine fistulaPTCTCAE E13234 Grade 3 Uterine fistula Grade 3 Uterine hemorrhage NCISevere bleeding; transfusion indicated; radiologic or endoscopic intervention indicated Grade 3 Uterine hemorrhagePTCTCAE E13240 Grade 3 Uterine hemorrhage Grade 3 Uterine infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Uterine infectionPTCTCAE E11621 Grade 3 Uterine infection Grade 3 Uterine obstruction NCISevere symptoms; elective operative intervention indicated Grade 3 Uterine obstructionPTCTCAE E13246 Grade 3 Uterine obstruction Grade 3 Uterine pain NCISevere pain; limiting self care ADL Grade 3 Uterine painPTCTCAE E13250 Grade 3 Uterine pain Grade 3 Uterine perforation NCISevere symptoms; elective operative intervention indicated Grade 3 Uterine perforationPTCTCAE E12031 Grade 3 Uterine perforation Grade 3 Uveitis NCIPosterior or pan-uveitis Grade 3 UveitisPTCTCAE E10445 Grade 3 Uveitis Grade 3 Vaginal anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Vaginal anastomotic leakPTCTCAE E12037 Grade 3 Vaginal anastomotic leak Grade 3 Vaginal dryness NCISevere vaginal dryness resulting in dyspareunia or severe discomfort Grade 3 Vaginal drynessPTCTCAE E13257 Grade 3 Vaginal dryness Grade 3 Vaginal fistula NCISevere symptoms; elective operative intervention indicated Grade 3 Vaginal fistulaPTCTCAE E13261 Grade 3 Vaginal fistula Grade 3 Vaginal hemorrhage NCISevere bleeding; transfusion indicated; radiologic or endoscopic intervention indicated Grade 3 Vaginal hemorrhagePTCTCAE E13267 Grade 3 Vaginal hemorrhage Grade 3 Vaginal infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Vaginal infectionPTCTCAE E11626 Grade 3 Vaginal infection Grade 3 Vaginal inflammation NCISevere discomfort or pain, edema, or redness; limiting self care ADL; small areas of mucosal ulceration Grade 3 Vaginal inflammationPTCTCAE E13273 Grade 3 Vaginal inflammation Grade 3 Vaginal obstruction NCISevere symptoms; elective operative intervention indicated Grade 3 Vaginal obstructionPTCTCAE E13279 Grade 3 Vaginal obstruction Grade 3 Vaginal pain NCISevere pain; limiting self care ADL Grade 3 Vaginal painPTCTCAE E13283 Grade 3 Vaginal pain Grade 3 Vaginal perforation NCISevere symptoms; elective operative intervention indicated Grade 3 Vaginal perforationPTCTCAE E13287 Grade 3 Vaginal perforation Grade 3 Vaginal stricture NCIVaginal narrowing and/or shortening interfering with the use of tampons, sexual activity or physical examination Grade 3 Vaginal stricturePTCTCAE E13293 Grade 3 Vaginal stricture Grade 3 Vaginismus NCISevere discomfort or pain associated with vaginal spasm/tightening; unable to tolerate vaginal penetration or physical examination Grade 3 VaginismusPTCTCAE E13298 Grade 3 Vaginismus Grade 3 Vagus nerve disorder NCISevere symptoms; limiting self care ADL Grade 3 Vagus nerve disorderPTCTCAE E12848 Grade 3 Vagus nerve disorder Grade 3 Vas deferens anastomotic leak NCISevere symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 Vas deferens anastomotic leakPTCTCAE E12043 Grade 3 Vas deferens anastomotic leak Grade 3 Vascular access complication NCIDeep vein or cardiac thrombosis; intervention indicated (e.g., anticoagulation, lysis, filter, invasive procedure) Grade 3 Vascular access complicationPTCTCAE E12048 Grade 3 Vascular access complication Grade 3 Vascular disorders - Other, specify NCISevere or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Grade 3 Vascular disorders - Other, specifyPTCTCAE E13834 Grade 3 Vascular disorders - Other, specify Grade 3 Vasculitis NCISevere symptoms, medical intervention indicated (e.g., steroids) Grade 3 VasculitisPTCTCAE E13840 Grade 3 Vasculitis Grade 3 Vasovagal reaction NCIPresent Grade 3 Vasovagal reactionPTCTCAE E12852 Grade 3 Vasovagal reaction Grade 3 Venous injury NCISevere symptoms; limiting self care ADL; repair or revision indicated; disabling Grade 3 Venous injuryPTCTCAE E12054 Grade 3 Venous injury Grade 3 Ventricular arrhythmia NCIMedical intervention indicated Grade 3 Ventricular arrhythmiaPTCTCAE E10233 Grade 3 Ventricular arrhythmia Grade 3 Ventricular tachycardia NCIMedical intervention indicated Grade 3 Ventricular tachycardiaPTCTCAE E10241 Grade 3 Ventricular tachycardia Grade 3 Vertigo NCISevere symptoms; limiting self care ADL Grade 3 VertigoPTCTCAE E10294 Grade 3 Vertigo Grade 3 Vestibular disorder NCISevere symptoms; limiting self care ADL Grade 3 Vestibular disorderPTCTCAE E10297 Grade 3 Vestibular disorder Grade 3 Visceral arterial ischemia NCIProlonged (>=24 hrs) or recurring symptoms and/or invasive intervention indicated Grade 3 Visceral arterial ischemiaPTCTCAE E13845 Grade 3 Visceral arterial ischemia Grade 3 Vital capacity abnormal NCI<50% of predicted value; limiting self care ADL Grade 3 Vital capacity abnormalPTCTCAE E12223 Grade 3 Vital capacity abnormal Grade 3 Vitreous hemorrhage NCILimiting self care ADL; vitrectomy indicated Grade 3 Vitreous hemorrhagePTCTCAE E10450 Grade 3 Vitreous hemorrhage Grade 3 Voice alteration NCISevere voice changes including predominantly whispered speech; may require frequent repetition or face-to-face contact for understandability; may require assistive technology Grade 3 Voice alterationPTCTCAE E13604 Grade 3 Voice alteration Grade 3 Vomiting NCI>=6 episodes (separated by 5 minutes) in 24 hrs; tube feeding, TPN or hospitalization indicated Grade 3 VomitingPTCTCAE E11071 Grade 3 Vomiting Grade 3 Vulval infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Vulval infectionPTCTCAE E11632 Grade 3 Vulval infection Grade 3 Watering eyes NCIOperative intervention indicated Grade 3 Watering eyesPTCTCAE E10455 Grade 3 Watering eyes Grade 3 Weight gain NCI>=20% from baseline Grade 3 Weight gainPTCTCAE E12227 Grade 3 Weight gain Grade 3 Weight loss NCI>=20% from baseline; tube feeding or TPN indicated Grade 3 Weight lossPTCTCAE E12231 Grade 3 Weight loss Grade 3 Wheezing NCISevere respiratory symptoms limiting self care ADL; oxygen therapy or hospitalization indicated Grade 3 WheezingPTCTCAE E13608 Grade 3 Wheezing Grade 3 White blood cell decreased NCI<2000 - 1000/mm3; <2.0 - 1.0 x 10e9 /L Grade 3 White blood cell decreasedPTCTCAE E12235 Grade 3 White blood cell decreased Grade 3 Wolff-Parkinson-White syndrome NCISymptomatic and incompletely controlled medically or controlled with procedure Grade 3 Wolff-Parkinson-White syndromePTCTCAE E10247 Grade 3 Wolff-Parkinson-White syndrome Grade 3 Wound complication NCIHernia without evidence of strangulation; fascial disruption/dehiscence; primary wound closure or revision by operative intervention indicated Grade 3 Wound complicationPTCTCAE E12060 Grade 3 Wound complication Grade 3 Wound dehiscence NCIFascial disruption or dehiscence without evisceration; primary wound closure or revision by operative intervention indicated Grade 3 Wound dehiscencePTCTCAE E12066 Grade 3 Wound dehiscence Grade 3 Wound infection NCIIV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 Wound infectionPTCTCAE E11637 Grade 3 Wound infection Grade 3 Wrist fracture NCILimiting self care ADL; elective surgery indicated Grade 3 Wrist fracturePTCTCAE E12072 Grade 3 Wrist fracture Grade 4 Abdominal infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Abdominal infectionPTCTCAE E11284 Grade 4 Abdominal infection Grade 4 Abdominal soft tissue necrosis NCILife-threatening consequences; urgent intervention indicated Grade 4 Abdominal soft tissue necrosisPTCTCAE E12372 Grade 4 Abdominal soft tissue necrosis Grade 4 Acidosis NCILife-threatening consequences Grade 4 AcidosisPTCTCAE E12240 Grade 4 Acidosis Grade 4 Acute coronary syndrome NCISymptomatic, unstable angina and/or acute myocardial infarction, cardiac enzymes abnormal, hemodynamically unstable Grade 4 Acute coronary syndromePTCTCAE E10069 Grade 4 Acute coronary syndrome Grade 4 Acute kidney injury NCILife-threatening consequences; dialysis indicated Grade 4 Acute kidney injuryPTCTCAE E12977 Grade 4 Acute kidney injury Grade 4 Adrenal insufficiency NCILife-threatening consequences; urgent intervention indicated Grade 4 Adrenal insufficiencyPTCTCAE E10302 Grade 4 Adrenal insufficiency Grade 4 Adult respiratory distress syndrome NCILife-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated Grade 4 Adult respiratory distress syndromePTCTCAE E13301 Grade 4 Adult respiratory distress syndrome Grade 4 Adverse Event NCIAn adverse event that has life-threatening consequences, for which urgent intervention is indicated, that puts the patient is at risk of death at the time of the event if immediate intervention is not undertaken, or that causes blindness or deafness (need to decide if unilateral or bilateral). Grade 4 Adverse EventPTCTCAE Life-threatening Adverse EventSYCTCAE E10008 Grade 4 Adverse Event Grade 4 Agitation NCILife-threatening consequences; urgent intervention indicated Grade 4 AgitationPTCTCAE E12878 Grade 4 Agitation Grade 4 Alanine aminotransferase increased NCI>20.0 x ULN Grade 4 Alanine aminotransferase increasedPTCTCAE E12081 Grade 4 Alanine aminotransferase increased Grade 4 Alcohol intolerance NCILife-threatening consequences; urgent intervention indicated Grade 4 Alcohol intolerancePTCTCAE E12245 Grade 4 Alcohol intolerance Grade 4 Alkaline phosphatase increased NCI>20.0 x ULN Grade 4 Alkaline phosphatase increasedPTCTCAE E12086 Grade 4 Alkaline phosphatase increased Grade 4 Alkalosis NCILife-threatening consequences Grade 4 AlkalosisPTCTCAE E12250 Grade 4 Alkalosis Grade 4 Allergic reaction NCILife-threatening consequences; urgent intervention indicated Grade 4 Allergic reactionPTCTCAE E11252 Grade 4 Allergic reaction Grade 4 Anal fistula NCILife-threatening consequences; urgent intervention indicated Grade 4 Anal fistulaPTCTCAE E10468 Grade 4 Anal fistula Grade 4 Anal hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Anal hemorrhagePTCTCAE E10474 Grade 4 Anal hemorrhage Grade 4 Anal mucositis NCILife-threatening consequences; urgent intervention indicated Grade 4 Anal mucositisPTCTCAE E10480 Grade 4 Anal mucositis Grade 4 Anal necrosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Anal necrosisPTCTCAE E10484 Grade 4 Anal necrosis Grade 4 Anal stenosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Anal stenosisPTCTCAE E10494 Grade 4 Anal stenosis Grade 4 Anal ulcer NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Anal ulcerPTCTCAE E10500 Grade 4 Anal ulcer Grade 4 Anaphylaxis NCILife-threatening consequences; urgent intervention indicated Grade 4 AnaphylaxisPTCTCAE E11256 Grade 4 Anaphylaxis Grade 4 Anemia NCILife-threatening consequences; urgent intervention indicated Grade 4 AnemiaPTCTCAE E10014 Grade 4 Anemia Grade 4 Anorectal infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Anorectal infectionPTCTCAE E11290 Grade 4 Anorectal infection Grade 4 Anorexia NCILife-threatening consequences; urgent intervention indicated Grade 4 AnorexiaPTCTCAE E12256 Grade 4 Anorexia Grade 4 Anxiety NCILife-threatening; hospitalization indicated Grade 4 AnxietyPTCTCAE E12887 Grade 4 Anxiety Grade 4 Aortic injury NCILife-threatening consequences; evidence of end organ damage; urgent operative intervention indicated Grade 4 Aortic injuryPTCTCAE E11646 Grade 4 Aortic injury Grade 4 Aortic valve disease NCILife-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) Grade 4 Aortic valve diseasePTCTCAE E10075 Grade 4 Aortic valve disease Grade 4 Apnea NCILife-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated Grade 4 ApneaPTCTCAE E13308 Grade 4 Apnea Grade 4 Appendicitis NCILife-threatening consequences; urgent intervention indicated Grade 4 AppendicitisPTCTCAE E11294 Grade 4 Appendicitis Grade 4 Appendicitis perforated NCILife-threatening consequences; urgent intervention indicated Grade 4 Appendicitis perforatedPTCTCAE E11299 Grade 4 Appendicitis perforated Grade 4 Arachnoiditis NCILife-threatening consequences; urgent intervention indicated Grade 4 ArachnoiditisPTCTCAE E12595 Grade 4 Arachnoiditis Grade 4 Arterial injury NCILife-threatening consequences; evidence of end organ damage; urgent operative intervention indicated Grade 4 Arterial injuryPTCTCAE E11652 Grade 4 Arterial injury Grade 4 Arteritis infective NCILife-threatening consequences; urgent intervention indicated Grade 4 Arteritis infectivePTCTCAE E11303 Grade 4 Arteritis infective Grade 4 Ascites NCILife-threatening consequences; urgent operative intervention indicated Grade 4 AscitesPTCTCAE E10506 Grade 4 Ascites Grade 4 Aspartate aminotransferase increased NCI>20.0 x ULN Grade 4 Aspartate aminotransferase increasedPTCTCAE E12091 Grade 4 Aspartate aminotransferase increased Grade 4 Aspiration NCILife-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated Grade 4 AspirationPTCTCAE E13314 Grade 4 Aspiration Grade 4 Asystole NCILife-threatening consequences; urgent intervention indicated Grade 4 AsystolePTCTCAE E10079 Grade 4 Asystole Grade 4 Atelectasis NCILife-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated Grade 4 AtelectasisPTCTCAE E13320 Grade 4 Atelectasis Grade 4 Atrial fibrillation NCILife-threatening consequences; urgent intervention indicated Grade 4 Atrial fibrillationPTCTCAE E10085 Grade 4 Atrial fibrillation Grade 4 Atrial flutter NCILife-threatening consequences; urgent intervention indicated Grade 4 Atrial flutterPTCTCAE E10091 Grade 4 Atrial flutter Grade 4 Atrioventricular block complete NCILife-threatening consequences; urgent intervention indicated Grade 4 Atrioventricular block completePTCTCAE E10096 Grade 4 Atrioventricular block complete Grade 4 Autoimmune disorder NCILife-threatening consequences; urgent intervention indicated Grade 4 Autoimmune disorderPTCTCAE E11262 Grade 4 Autoimmune disorder Grade 4 Avascular necrosis NCILife-threatening consequences; urgent intervention indicated Grade 4 Avascular necrosisPTCTCAE E12386 Grade 4 Avascular necrosis Grade 4 Bile duct stenosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Bile duct stenosisPTCTCAE E11177 Grade 4 Bile duct stenosis Grade 4 Biliary anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Biliary anastomotic leakPTCTCAE E11658 Grade 4 Biliary anastomotic leak Grade 4 Biliary fistula NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Biliary fistulaPTCTCAE E11182 Grade 4 Biliary fistula Grade 4 Biliary tract infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Biliary tract infectionPTCTCAE E11307 Grade 4 Biliary tract infection Grade 4 Bladder anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Bladder anastomotic leakPTCTCAE E11664 Grade 4 Bladder anastomotic leak Grade 4 Bladder infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Bladder infectionPTCTCAE E11312 Grade 4 Bladder infection Grade 4 Bladder perforation NCILife-threatening consequences; organ failure; urgent operative intervention indicated Grade 4 Bladder perforationPTCTCAE E12982 Grade 4 Bladder perforation Grade 4 Blood and lymphatic system disorders - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Blood and lymphatic system disorders - Other, specifyPTCTCAE E10020 Grade 4 Blood and lymphatic system disorders - Other, specify Grade 4 Blood bilirubin increased NCI>10.0 x ULN Grade 4 Blood bilirubin increasedPTCTCAE E12100 Grade 4 Blood bilirubin increased Grade 4 Bone infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Bone infectionPTCTCAE E11316 Grade 4 Bone infection Grade 4 Bone marrow hypocellular NCIAplastic persistent for longer than 2 weeks Grade 4 Bone marrow hypocellularPTCTCAE E10026 Grade 4 Bone marrow hypocellular Grade 4 Breast infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Breast infectionPTCTCAE E11321 Grade 4 Breast infection Grade 4 Bronchial fistula NCILife-threatening consequences; urgent operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated Grade 4 Bronchial fistulaPTCTCAE E13326 Grade 4 Bronchial fistula Grade 4 Bronchial infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Bronchial infectionPTCTCAE E11326 Grade 4 Bronchial infection Grade 4 Bronchial obstruction NCILife-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated Grade 4 Bronchial obstructionPTCTCAE E13332 Grade 4 Bronchial obstruction Grade 4 Bronchial stricture NCILife-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated Grade 4 Bronchial stricturePTCTCAE E13338 Grade 4 Bronchial stricture Grade 4 Bronchopleural fistula NCILife-threatening consequences; urgent operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated Grade 4 Bronchopleural fistulaPTCTCAE E13344 Grade 4 Bronchopleural fistula Grade 4 Bronchopulmonary hemorrhage NCILife-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated Grade 4 Bronchopulmonary hemorrhagePTCTCAE E13350 Grade 4 Bronchopulmonary hemorrhage Grade 4 Bronchospasm NCILife-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated Grade 4 BronchospasmPTCTCAE E13356 Grade 4 Bronchospasm Grade 4 Bullous dermatitis NCIBlisters covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated Grade 4 Bullous dermatitisPTCTCAE E13621 Grade 4 Bullous dermatitis Grade 4 Burn NCILife-threatening consequences Grade 4 BurnPTCTCAE E11673 Grade 4 Burn Grade 4 CD4 lymphocytes decreased NCI<50/mm3; <0.05 x 10e9 /L Grade 4 CD4 lymphocytes decreasedPTCTCAE E12126 Grade 4 CD4 lymphocytes decreased Grade 4 CPK increased NCI>10 x ULN Grade 4 CPK increasedPTCTCAE E12136 Grade 4 CPK increased Grade 4 Capillary leak syndrome NCILife-threatening consequences; urgent intervention indicated Grade 4 Capillary leak syndromePTCTCAE E13769 Grade 4 Capillary leak syndrome Grade 4 Cardiac arrest NCILife-threatening consequences; urgent intervention indicated Grade 4 Cardiac arrestPTCTCAE E10102 Grade 4 Cardiac arrest Grade 4 Cardiac disorders - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Cardiac disorders - Other, specifyPTCTCAE E10108 Grade 4 Cardiac disorders - Other, specify Grade 4 Cataract NCIBlindness (20/200 or worse) in the affected eye Grade 4 CataractPTCTCAE E10354 Grade 4 Cataract Grade 4 Catheter related infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Catheter related infectionPTCTCAE E11331 Grade 4 Catheter related infection Grade 4 Cecal hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Cecal hemorrhagePTCTCAE E10515 Grade 4 Cecal hemorrhage Grade 4 Cecal infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Cecal infectionPTCTCAE E11335 Grade 4 Cecal infection Grade 4 Central nervous system necrosis NCILife-threatening consequences; urgent intervention indicated Grade 4 Central nervous system necrosisPTCTCAE E12609 Grade 4 Central nervous system necrosis Grade 4 Cerebrospinal fluid leakage NCILife-threatening consequences; urgent intervention indicated Grade 4 Cerebrospinal fluid leakagePTCTCAE E12615 Grade 4 Cerebrospinal fluid leakage Grade 4 Cervicitis infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Cervicitis infectionPTCTCAE E11340 Grade 4 Cervicitis infection Grade 4 Cholecystitis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 CholecystitisPTCTCAE E11187 Grade 4 Cholecystitis Grade 4 Cholesterol high NCI>500 mg/dL; >12.92 mmol/L Grade 4 Cholesterol highPTCTCAE E12131 Grade 4 Cholesterol high Grade 4 Chronic kidney disease NCIeGFR or CrCl <15 ml/min/1.73 m2; dialysis or renal transplant indicated Grade 4 Chronic kidney diseasePTCTCAE E12992 Grade 4 Chronic kidney disease Grade 4 Chylothorax NCILife-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated Grade 4 ChylothoraxPTCTCAE E13362 Grade 4 Chylothorax Grade 4 Colitis NCILife-threatening consequences; urgent intervention indicated Grade 4 ColitisPTCTCAE E10525 Grade 4 Colitis Grade 4 Colonic fistula NCILife-threatening consequences; urgent intervention indicated Grade 4 Colonic fistulaPTCTCAE E10531 Grade 4 Colonic fistula Grade 4 Colonic hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Colonic hemorrhagePTCTCAE E10537 Grade 4 Colonic hemorrhage Grade 4 Colonic obstruction NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Colonic obstructionPTCTCAE E10543 Grade 4 Colonic obstruction Grade 4 Colonic perforation NCILife-threatening consequences; urgent intervention indicated Grade 4 Colonic perforationPTCTCAE E10548 Grade 4 Colonic perforation Grade 4 Colonic stenosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Colonic stenosisPTCTCAE E10554 Grade 4 Colonic stenosis Grade 4 Colonic ulcer NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Colonic ulcerPTCTCAE E10560 Grade 4 Colonic ulcer Grade 4 Conduction disorder NCILife-threatening consequences; urgent intervention indicated Grade 4 Conduction disorderPTCTCAE E10118 Grade 4 Conduction disorder Grade 4 Confusion NCILife-threatening consequences; urgent intervention indicated Grade 4 ConfusionPTCTCAE E12893 Grade 4 Confusion Grade 4 Congenital, familial and genetic disorders - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Congenital, familial and genetic disorders - Other, specifyPTCTCAE E10254 Grade 4 Congenital, familial and genetic disorders - Other, specify Grade 4 Conjunctivitis infective NCILife-threatening consequences; urgent intervention indicated Grade 4 Conjunctivitis infectivePTCTCAE E11345 Grade 4 Conjunctivitis infective Grade 4 Constipation NCILife-threatening consequences; urgent intervention indicated Grade 4 ConstipationPTCTCAE E10566 Grade 4 Constipation Grade 4 Constrictive pericarditis NCIRefractory heart failure or other poorly controlled cardiac symptoms Grade 4 Constrictive pericarditisPTCTCAE E10122 Grade 4 Constrictive pericarditis Grade 4 Corneal infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Corneal infectionPTCTCAE E11350 Grade 4 Corneal infection Grade 4 Corneal ulcer NCIPerforation or blindness (20/200 or worse) in the affected eye Grade 4 Corneal ulcerPTCTCAE E10362 Grade 4 Corneal ulcer Grade 4 Cranial nerve infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Cranial nerve infectionPTCTCAE E11354 Grade 4 Cranial nerve infection Grade 4 Creatinine increased NCI>6.0 x ULN Grade 4 Creatinine increasedPTCTCAE E12141 Grade 4 Creatinine increased Grade 4 Cystitis noninfective NCILife-threatening consequences; urgent radiologic or operative intervention indicated Grade 4 Cystitis noninfectivePTCTCAE E12998 Grade 4 Cystitis noninfective Grade 4 Cytokine release syndrome NCILife-threatening consequences; pressor or ventilatory support indicated Grade 4 Cytokine release syndromePTCTCAE E11268 Grade 4 Cytokine release syndrome Grade 4 Dehydration NCILife-threatening consequences; urgent intervention indicated Grade 4 DehydrationPTCTCAE E12262 Grade 4 Dehydration Grade 4 Delirium NCILife-threatening consequences, threats of harm to self or others; hospitalization indicated Grade 4 DeliriumPTCTCAE E12902 Grade 4 Delirium Grade 4 Delusions NCILife-threatening consequences, threats of harm to self or others; hospitalization indicated Grade 4 DelusionsPTCTCAE E12907 Grade 4 Delusions Grade 4 Depressed level of consciousness NCILife-threatening consequences Grade 4 Depressed level of consciousnessPTCTCAE E12629 Grade 4 Depressed level of consciousness Grade 4 Depression NCILife-threatening consequences, threats of harm to self or others; hospitalization indicated Grade 4 DepressionPTCTCAE E12913 Grade 4 Depression Grade 4 Dermatitis radiation NCILife-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated Grade 4 Dermatitis radiationPTCTCAE E11679 Grade 4 Dermatitis radiation Grade 4 Device related infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Device related infectionPTCTCAE E11358 Grade 4 Device related infection Grade 4 Diarrhea NCILife-threatening consequences; urgent intervention indicated Grade 4 DiarrheaPTCTCAE E10576 Grade 4 Diarrhea Grade 4 Disseminated intravascular coagulation NCILife-threatening consequences; urgent intervention indicated Grade 4 Disseminated intravascular coagulationPTCTCAE E10031 Grade 4 Disseminated intravascular coagulation Grade 4 Duodenal fistula NCILife-threatening consequences; urgent intervention indicated Grade 4 Duodenal fistulaPTCTCAE E10586 Grade 4 Duodenal fistula Grade 4 Duodenal hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Duodenal hemorrhagePTCTCAE E10592 Grade 4 Duodenal hemorrhage Grade 4 Duodenal infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Duodenal infectionPTCTCAE E11363 Grade 4 Duodenal infection Grade 4 Duodenal obstruction NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Duodenal obstructionPTCTCAE E10598 Grade 4 Duodenal obstruction Grade 4 Duodenal perforation NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Duodenal perforationPTCTCAE E10603 Grade 4 Duodenal perforation Grade 4 Duodenal stenosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Duodenal stenosisPTCTCAE E10609 Grade 4 Duodenal stenosis Grade 4 Duodenal ulcer NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Duodenal ulcerPTCTCAE E10615 Grade 4 Duodenal ulcer Grade 4 Dysphagia NCILife-threatening consequences; urgent intervention indicated Grade 4 DysphagiaPTCTCAE E10625 Grade 4 Dysphagia Grade 4 Dyspnea NCILife-threatening consequences; urgent intervention indicated Grade 4 DyspneaPTCTCAE E13372 Grade 4 Dyspnea Grade 4 Ear and labyrinth disorders - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Ear and labyrinth disorders - Other, specifyPTCTCAE E10260 Grade 4 Ear and labyrinth disorders - Other, specify Grade 4 Edema cerebral NCILife-threatening consequences; urgent intervention indicated Grade 4 Edema cerebralPTCTCAE E12651 Grade 4 Edema cerebral Grade 4 Ejection fraction decreased NCIResting ejection fraction (EF) <20% Grade 4 Ejection fraction decreasedPTCTCAE E12145 Grade 4 Ejection fraction decreased Grade 4 Electrocardiogram QT corrected interval prolonged NCIQTc >= 501 or >60 ms change from baseline and Torsade de pointes or polymorphic ventricular tachycardia or signs/symptoms of serious arrhythmia Grade 4 Electrocardiogram QT corrected interval prolongedPTCTCAE E12150 Grade 4 Electrocardiogram QT corrected interval prolonged Grade 4 Encephalitis infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Encephalitis infectionPTCTCAE E11367 Grade 4 Encephalitis infection Grade 4 Encephalomyelitis infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Encephalomyelitis infectionPTCTCAE E11371 Grade 4 Encephalomyelitis infection Grade 4 Encephalopathy NCILife-threatening consequences; urgent intervention indicated Grade 4 EncephalopathyPTCTCAE E12656 Grade 4 Encephalopathy Grade 4 Endocarditis infective NCILife-threatening consequences; urgent intervention indicated Grade 4 Endocarditis infectivePTCTCAE E11375 Grade 4 Endocarditis infective Grade 4 Endocrine disorders - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Endocrine disorders - Other, specifyPTCTCAE E10315 Grade 4 Endocrine disorders - Other, specify Grade 4 Endophthalmitis NCIBlindness (20/200 or worse) Grade 4 EndophthalmitisPTCTCAE E11380 Grade 4 Endophthalmitis Grade 4 Enterocolitis NCILife-threatening consequences; urgent intervention indicated Grade 4 EnterocolitisPTCTCAE E10631 Grade 4 Enterocolitis Grade 4 Enterocolitis infectious NCILife-threatening consequences; urgent intervention indicated Grade 4 Enterocolitis infectiousPTCTCAE E11384 Grade 4 Enterocolitis infectious Grade 4 Enterovesical fistula NCILife-threatening consequences; urgent intervention indicated Grade 4 Enterovesical fistulaPTCTCAE E10637 Grade 4 Enterovesical fistula Grade 4 Epistaxis NCILife-threatening consequences; urgent intervention indicated Grade 4 EpistaxisPTCTCAE E13378 Grade 4 Epistaxis Grade 4 Erythema multiforme NCITarget lesions covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated Grade 4 Erythema multiformePTCTCAE E13631 Grade 4 Erythema multiforme Grade 4 Erythroderma NCIErythema covering >90% BSA with associated fluid or electrolyte abnormalities; ICU care or burn unit indicated Grade 4 ErythrodermaPTCTCAE E13636 Grade 4 Erythroderma Grade 4 Esophageal anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Esophageal anastomotic leakPTCTCAE E11685 Grade 4 Esophageal anastomotic leak Grade 4 Esophageal fistula NCILife-threatening consequences; urgent intervention indicated Grade 4 Esophageal fistulaPTCTCAE E10643 Grade 4 Esophageal fistula Grade 4 Esophageal hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Esophageal hemorrhagePTCTCAE E10649 Grade 4 Esophageal hemorrhage Grade 4 Esophageal infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Esophageal infectionPTCTCAE E11389 Grade 4 Esophageal infection Grade 4 Esophageal necrosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Esophageal necrosisPTCTCAE E10653 Grade 4 Esophageal necrosis Grade 4 Esophageal obstruction NCILife-threatening consequences; urgent intervention indicated Grade 4 Esophageal obstructionPTCTCAE E10659 Grade 4 Esophageal obstruction Grade 4 Esophageal perforation NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Esophageal perforationPTCTCAE E10668 Grade 4 Esophageal perforation Grade 4 Esophageal stenosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Esophageal stenosisPTCTCAE E10674 Grade 4 Esophageal stenosis Grade 4 Esophageal ulcer NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Esophageal ulcerPTCTCAE E10680 Grade 4 Esophageal ulcer Grade 4 Esophageal varices hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Esophageal varices hemorrhagePTCTCAE E10685 Grade 4 Esophageal varices hemorrhage Grade 4 Esophagitis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 EsophagitisPTCTCAE E10691 Grade 4 Esophagitis Grade 4 External ear inflammation NCIUrgent operative intervention indicated Grade 4 External ear inflammationPTCTCAE E10270 Grade 4 External ear inflammation Grade 4 Extrapyramidal disorder NCILife-threatening consequences; urgent intervention indicated Grade 4 Extrapyramidal disorderPTCTCAE E12662 Grade 4 Extrapyramidal disorder Grade 4 Eye disorders - Other, specify NCISight-threatening consequences; urgent intervention indicated; blindness (20/200 or worse) in the affected eye Grade 4 Eye disorders - Other, specifyPTCTCAE E10375 Grade 4 Eye disorders - Other, specify Grade 4 Eye infection NCILife-threatening consequences; urgent intervention indicated; enucleation Grade 4 Eye infectionPTCTCAE E11394 Grade 4 Eye infection Grade 4 Fallopian tube anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Fallopian tube anastomotic leakPTCTCAE E11695 Grade 4 Fallopian tube anastomotic leak Grade 4 Fallopian tube perforation NCILife-threatening consequences; urgent operative intervention indicated (e.g., organ resection) Grade 4 Fallopian tube perforationPTCTCAE E11701 Grade 4 Fallopian tube perforation Grade 4 Fallopian tube stenosis NCILife-threatening consequences; urgent operative intervention indicated (e.g., organ resection) Grade 4 Fallopian tube stenosisPTCTCAE E13100 Grade 4 Fallopian tube stenosis Grade 4 Febrile neutropenia NCILife-threatening consequences; urgent intervention indicated Grade 4 Febrile neutropeniaPTCTCAE E10035 Grade 4 Febrile neutropenia Grade 4 Female genital tract fistula NCILife-threatening consequences; urgent intervention indicated Grade 4 Female genital tract fistulaPTCTCAE E13106 Grade 4 Female genital tract fistula Grade 4 Fetal growth retardation NCI<1% percentile of weight for gestational age Grade 4 Fetal growth retardationPTCTCAE E12860 Grade 4 Fetal growth retardation Grade 4 Fever NCI>40.0 degrees C (>104.0 degrees F) for >24 hrs Grade 4 FeverPTCTCAE E11106 Grade 4 Fever Grade 4 Fibrinogen decreased NCI<0.25 x LLN or 75% decrease from baseline or absolute value <50 mg/dL Grade 4 Fibrinogen decreasedPTCTCAE E12155 Grade 4 Fibrinogen decreased Grade 4 Fibrosis deep connective tissue NCIGeneralized; associated with signs or symptoms of impaired breathing or feeding Grade 4 Fibrosis deep connective tissuePTCTCAE E12412 Grade 4 Fibrosis deep connective tissue Grade 4 Forced expiratory volume decreased NCI<= 49% Grade 4 Forced expiratory volume decreasedPTCTCAE E12160 Grade 4 Forced expiratory volume decreased Grade 4 Fracture NCILife-threatening consequences; urgent intervention indicated Grade 4 FracturePTCTCAE E11707 Grade 4 Fracture Grade 4 GGT increased NCI>20.0 x ULN Grade 4 GGT increasedPTCTCAE E12165 Grade 4 GGT increased Grade 4 Gallbladder fistula NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Gallbladder fistulaPTCTCAE E11193 Grade 4 Gallbladder fistula Grade 4 Gallbladder infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Gallbladder infectionPTCTCAE E11398 Grade 4 Gallbladder infection Grade 4 Gallbladder necrosis NCILife-threatening consequences; urgent radiologic or operative intervention indicated Grade 4 Gallbladder necrosisPTCTCAE E11196 Grade 4 Gallbladder necrosis Grade 4 Gallbladder obstruction NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Gallbladder obstructionPTCTCAE E11202 Grade 4 Gallbladder obstruction Grade 4 Gallbladder perforation NCILife-threatening consequences; urgent intervention indicated Grade 4 Gallbladder perforationPTCTCAE E11209 Grade 4 Gallbladder perforation Grade 4 Gastric anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Gastric anastomotic leakPTCTCAE E11713 Grade 4 Gastric anastomotic leak Grade 4 Gastric fistula NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Gastric fistulaPTCTCAE E10704 Grade 4 Gastric fistula Grade 4 Gastric hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Gastric hemorrhagePTCTCAE E10710 Grade 4 Gastric hemorrhage Grade 4 Gastric necrosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Gastric necrosisPTCTCAE E10714 Grade 4 Gastric necrosis Grade 4 Gastric perforation NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Gastric perforationPTCTCAE E10719 Grade 4 Gastric perforation Grade 4 Gastric stenosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Gastric stenosisPTCTCAE E10725 Grade 4 Gastric stenosis Grade 4 Gastric ulcer NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Gastric ulcerPTCTCAE E10731 Grade 4 Gastric ulcer Grade 4 Gastritis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 GastritisPTCTCAE E10737 Grade 4 Gastritis Grade 4 Gastrointestinal anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Gastrointestinal anastomotic leakPTCTCAE E11719 Grade 4 Gastrointestinal anastomotic leak Grade 4 Gastrointestinal disorders - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Gastrointestinal disorders - Other, specifyPTCTCAE E10747 Grade 4 Gastrointestinal disorders - Other, specify Grade 4 Gastrointestinal fistula NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Gastrointestinal fistulaPTCTCAE E10753 Grade 4 Gastrointestinal fistula Grade 4 Gastrointestinal stoma necrosis NCILife-threatening consequences; urgent intervention indicated Grade 4 Gastrointestinal stoma necrosisPTCTCAE E11724 Grade 4 Gastrointestinal stoma necrosis Grade 4 General disorders and administration site conditions - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 General disorders and administration site conditions - Other, specifyPTCTCAE E11120 Grade 4 General disorders and administration site conditions - Other, specify Grade 4 Glaucoma NCIBlindness (20/200 or worse) in the affected eye Grade 4 GlaucomaPTCTCAE E10396 Grade 4 Glaucoma Grade 4 Glossopharyngeal nerve disorder NCILife-threatening consequences; urgent intervention indicated Grade 4 Glossopharyngeal nerve disorderPTCTCAE E12676 Grade 4 Glossopharyngeal nerve disorder Grade 4 Glucose intolerance NCILife-threatening consequences; urgent intervention indicated Grade 4 Glucose intolerancePTCTCAE E12268 Grade 4 Glucose intolerance Grade 4 Gum infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Gum infectionPTCTCAE E11404 Grade 4 Gum infection Grade 4 Hallucinations NCILife-threatening consequences, threats of harm to self or others; hospitalization indicated Grade 4 HallucinationsPTCTCAE E12923 Grade 4 Hallucinations Grade 4 Head soft tissue necrosis NCILife-threatening consequences; urgent intervention indicated Grade 4 Head soft tissue necrosisPTCTCAE E12429 Grade 4 Head soft tissue necrosis Grade 4 Hearing impaired NCIAdults: Decrease in hearing to profound bilateral loss (absolute threshold >80 dB HL at 2 kHz and above); non-servicable hearing. Pediatric: Audiologic indication for cochlear implant and additional speech-language related services indicated. Grade 4 Hearing impairedPTCTCAE E10280 Grade 4 Hearing impaired Grade 4 Heart failure NCILife-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support) Grade 4 Heart failurePTCTCAE E10128 Grade 4 Heart failure Grade 4 Hematoma NCILife-threatening consequences; urgent intervention indicated Grade 4 HematomaPTCTCAE E13779 Grade 4 Hematoma Grade 4 Hematosalpinx NCILife-threatening consequences; urgent operative intervention indicated Grade 4 HematosalpinxPTCTCAE E13123 Grade 4 Hematosalpinx Grade 4 Hematuria NCILife-threatening consequences; urgent radiologic or operative intervention indicated Grade 4 HematuriaPTCTCAE E13004 Grade 4 Hematuria Grade 4 Hemolysis NCILife-threatening consequences; urgent intervention indicated Grade 4 HemolysisPTCTCAE E10041 Grade 4 Hemolysis Grade 4 Hemolytic uremic syndrome NCILife-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure) Grade 4 Hemolytic uremic syndromePTCTCAE E10046 Grade 4 Hemolytic uremic syndrome Grade 4 Hemorrhoidal hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Hemorrhoidal hemorrhagePTCTCAE E10771 Grade 4 Hemorrhoidal hemorrhage Grade 4 Hepatic failure NCIModerate to severe encephalopathy; coma; life-threatening consequences Grade 4 Hepatic failurePTCTCAE E11213 Grade 4 Hepatic failure Grade 4 Hepatic hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Hepatic hemorrhagePTCTCAE E11219 Grade 4 Hepatic hemorrhage Grade 4 Hepatic infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Hepatic infectionPTCTCAE E11408 Grade 4 Hepatic infection Grade 4 Hepatic necrosis NCILife-threatening consequences; urgent radiologic or operative intervention indicated Grade 4 Hepatic necrosisPTCTCAE E11222 Grade 4 Hepatic necrosis Grade 4 Hepatitis viral NCIDecompensated liver function (e.g., ascites, coagulopathy, encephalopathy, coma) Grade 4 Hepatitis viralPTCTCAE E11413 Grade 4 Hepatitis viral Grade 4 Hepatobiliary disorders - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Hepatobiliary disorders - Other, specifyPTCTCAE E11232 Grade 4 Hepatobiliary disorders - Other, specify Grade 4 Hip fracture NCILife-threatening consequences; symptoms associated with neurovascular compromise Grade 4 Hip fracturePTCTCAE E11729 Grade 4 Hip fracture Grade 4 Hydrocephalus NCILife-threatening consequences; urgent intervention indicated Grade 4 HydrocephalusPTCTCAE E12686 Grade 4 Hydrocephalus Grade 4 Hypercalcemia NCICorrected serum calcium of >13.5 mg/dL; >3.4 mmol/L; Ionized calcium >1.8 mmol/L; life-threatening consequences Grade 4 HypercalcemiaPTCTCAE E12274 Grade 4 Hypercalcemia Grade 4 Hyperglycemia NCI>500 mg/dL; >27.8 mmol/L; life-threatening consequences Grade 4 HyperglycemiaPTCTCAE E12280 Grade 4 Hyperglycemia Grade 4 Hyperkalemia NCI>7.0 mmol/L; life-threatening consequences Grade 4 HyperkalemiaPTCTCAE E12286 Grade 4 Hyperkalemia Grade 4 Hypermagnesemia NCI>8.0 mg/dL; >3.30 mmol/L; life-threatening consequences Grade 4 HypermagnesemiaPTCTCAE E12291 Grade 4 Hypermagnesemia Grade 4 Hypernatremia NCI>160 mmol/L; life-threatening consequences Grade 4 HypernatremiaPTCTCAE E12297 Grade 4 Hypernatremia Grade 4 Hypertension NCILife-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated Pediatric: Same as adult Grade 4 HypertensionPTCTCAE E13789 Grade 4 Hypertension Grade 4 Hyperthyroidism NCILife-threatening consequences; urgent intervention indicated Grade 4 HyperthyroidismPTCTCAE E10326 Grade 4 Hyperthyroidism Grade 4 Hypertriglyceridemia NCI>1000 mg/dL; >11.4 mmol/L; life-threatening consequences Grade 4 HypertriglyceridemiaPTCTCAE E12303 Grade 4 Hypertriglyceridemia Grade 4 Hyperuricemia NCI>10 mg/dL; >0.59 mmol/L; life-threatening consequences Grade 4 HyperuricemiaPTCTCAE E12308 Grade 4 Hyperuricemia Grade 4 Hypoalbuminemia NCILife-threatening consequences; urgent intervention indicated Grade 4 HypoalbuminemiaPTCTCAE E12314 Grade 4 Hypoalbuminemia Grade 4 Hypocalcemia NCICorrected serum calcium of <6.0 mg/dL; <1.5 mmol/L; Ionized calcium <0.8 mmol/L; life-threatening consequences Grade 4 HypocalcemiaPTCTCAE E12320 Grade 4 Hypocalcemia Grade 4 Hypoglycemia NCI<30 mg/dL; <1.7 mmol/L; life-threatening consequences; seizures Grade 4 HypoglycemiaPTCTCAE E12325 Grade 4 Hypoglycemia Grade 4 Hypohidrosis NCIHeat stroke Grade 4 HypohidrosisPTCTCAE E13655 Grade 4 Hypohidrosis Grade 4 Hypokalemia NCI<2.5 mmol/L; life-threatening consequences Grade 4 HypokalemiaPTCTCAE E12331 Grade 4 Hypokalemia Grade 4 Hypomagnesemia NCI<0.7 mg/dL; <0.3 mmol/L; life-threatening consequences Grade 4 HypomagnesemiaPTCTCAE E12337 Grade 4 Hypomagnesemia Grade 4 Hyponatremia NCI<120 mmol/L; life-threatening consequences Grade 4 HyponatremiaPTCTCAE E12342 Grade 4 Hyponatremia Grade 4 Hypoparathyroidism NCILife-threatening consequences; urgent intervention indicated Grade 4 HypoparathyroidismPTCTCAE E10332 Grade 4 Hypoparathyroidism Grade 4 Hypophosphatemia NCI<1.0 mg/dL; <0.3 mmol/L; life-threatening consequences Grade 4 HypophosphatemiaPTCTCAE E12348 Grade 4 Hypophosphatemia Grade 4 Hypotension NCILife-threatening and urgent intervention indicated Grade 4 HypotensionPTCTCAE E13795 Grade 4 Hypotension Grade 4 Hypothermia NCI<=28 degrees C; 82.4 degrees F; life-threatening consequences (e.g., coma, hypotension, pulmonary edema, acidemia, ventricular fibrillation) Grade 4 HypothermiaPTCTCAE E11125 Grade 4 Hypothermia Grade 4 Hypothyroidism NCILife-threatening consequences; urgent intervention indicated Grade 4 HypothyroidismPTCTCAE E10338 Grade 4 Hypothyroidism Grade 4 Hypoxia NCILife-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) Grade 4 HypoxiaPTCTCAE E13391 Grade 4 Hypoxia Grade 4 Ileal fistula NCILife-threatening consequences; urgent intervention indicated Grade 4 Ileal fistulaPTCTCAE E10781 Grade 4 Ileal fistula Grade 4 Ileal hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Ileal hemorrhagePTCTCAE E10787 Grade 4 Ileal hemorrhage Grade 4 Ileal obstruction NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Ileal obstructionPTCTCAE E10793 Grade 4 Ileal obstruction Grade 4 Ileal perforation NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Ileal perforationPTCTCAE E10798 Grade 4 Ileal perforation Grade 4 Ileal stenosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Ileal stenosisPTCTCAE E10804 Grade 4 Ileal stenosis Grade 4 Ileal ulcer NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Ileal ulcerPTCTCAE E10810 Grade 4 Ileal ulcer Grade 4 Ileus NCILife-threatening consequences; urgent intervention indicated Grade 4 IleusPTCTCAE E10815 Grade 4 Ileus Grade 4 Immune system disorders - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Immune system disorders - Other, specifyPTCTCAE E11274 Grade 4 Immune system disorders - Other, specify Grade 4 Infections and infestations - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Infections and infestations - Other, specifyPTCTCAE E11419 Grade 4 Infections and infestations - Other, specify Grade 4 Infective myositis NCILife-threatening consequences; urgent intervention indicated Grade 4 Infective myositisPTCTCAE E11424 Grade 4 Infective myositis Grade 4 Infusion related reaction NCILife-threatening consequences; urgent intervention indicated Grade 4 Infusion related reactionPTCTCAE E11131 Grade 4 Infusion related reaction Grade 4 Infusion site extravasation NCILife-threatening consequences; urgent intervention indicated Grade 4 Infusion site extravasationPTCTCAE E11136 Grade 4 Infusion site extravasation Grade 4 Injection site reaction NCILife-threatening consequences; urgent intervention indicated Grade 4 Injection site reactionPTCTCAE E11142 Grade 4 Injection site reaction Grade 4 Injury, poisoning and procedural complications - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Injury, poisoning and procedural complications - Other, specifyPTCTCAE E11751 Grade 4 Injury, poisoning and procedural complications - Other, specify Grade 4 Injury to carotid artery NCILife-threatening consequences; urgent intervention indicated Grade 4 Injury to carotid arteryPTCTCAE E11732 Grade 4 Injury to carotid artery Grade 4 Injury to inferior vena cava NCILife-threatening consequences; urgent intervention indicated Grade 4 Injury to inferior vena cavaPTCTCAE E11735 Grade 4 Injury to inferior vena cava Grade 4 Injury to jugular vein NCILife-threatening consequences; urgent intervention indicated Grade 4 Injury to jugular veinPTCTCAE E11739 Grade 4 Injury to jugular vein Grade 4 Injury to superior vena cava NCILife-threatening consequences; evidence of end organ damage; urgent operative intervention indicated Grade 4 Injury to superior vena cavaPTCTCAE E11745 Grade 4 Injury to superior vena cava Grade 4 Intestinal stoma leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Intestinal stoma leakPTCTCAE E11757 Grade 4 Intestinal stoma leak Grade 4 Intestinal stoma obstruction NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Intestinal stoma obstructionPTCTCAE E11762 Grade 4 Intestinal stoma obstruction Grade 4 Intestinal stoma site bleeding NCILife-threatening consequences; urgent intervention indicated Grade 4 Intestinal stoma site bleedingPTCTCAE E11768 Grade 4 Intestinal stoma site bleeding Grade 4 Intra-abdominal hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Intra-abdominal hemorrhagePTCTCAE E10820 Grade 4 Intra-abdominal hemorrhage Grade 4 Intracranial hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Intracranial hemorrhagePTCTCAE E12700 Grade 4 Intracranial hemorrhage Grade 4 Intraoperative arterial injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative arterial injuryPTCTCAE E11774 Grade 4 Intraoperative arterial injury Grade 4 Intraoperative breast injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative breast injuryPTCTCAE E11780 Grade 4 Intraoperative breast injury Grade 4 Intraoperative cardiac injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative cardiac injuryPTCTCAE E11784 Grade 4 Intraoperative cardiac injury Grade 4 Intraoperative ear injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative ear injuryPTCTCAE E11790 Grade 4 Intraoperative ear injury Grade 4 Intraoperative endocrine injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative endocrine injuryPTCTCAE E11796 Grade 4 Intraoperative endocrine injury Grade 4 Intraoperative gastrointestinal injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative gastrointestinal injuryPTCTCAE E11802 Grade 4 Intraoperative gastrointestinal injury Grade 4 Intraoperative head and neck injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative head and neck injuryPTCTCAE E11808 Grade 4 Intraoperative head and neck injury Grade 4 Intraoperative hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative hemorrhagePTCTCAE E11812 Grade 4 Intraoperative hemorrhage Grade 4 Intraoperative hepatobiliary injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative hepatobiliary injuryPTCTCAE E11818 Grade 4 Intraoperative hepatobiliary injury Grade 4 Intraoperative musculoskeletal injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative musculoskeletal injuryPTCTCAE E11824 Grade 4 Intraoperative musculoskeletal injury Grade 4 Intraoperative neurological injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative neurological injuryPTCTCAE E11830 Grade 4 Intraoperative neurological injury Grade 4 Intraoperative ocular injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative ocular injuryPTCTCAE E11836 Grade 4 Intraoperative ocular injury Grade 4 Intraoperative renal injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative renal injuryPTCTCAE E11842 Grade 4 Intraoperative renal injury Grade 4 Intraoperative reproductive tract injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative reproductive tract injuryPTCTCAE E11848 Grade 4 Intraoperative reproductive tract injury Grade 4 Intraoperative respiratory injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative respiratory injuryPTCTCAE E11854 Grade 4 Intraoperative respiratory injury Grade 4 Intraoperative skin injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative skin injuryPTCTCAE E11860 Grade 4 Intraoperative skin injury Grade 4 Intraoperative splenic injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative splenic injuryPTCTCAE E11865 Grade 4 Intraoperative splenic injury Grade 4 Intraoperative urinary injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative urinary injuryPTCTCAE E11871 Grade 4 Intraoperative urinary injury Grade 4 Intraoperative venous injury NCILife-threatening consequences; urgent intervention indicated Grade 4 Intraoperative venous injuryPTCTCAE E11877 Grade 4 Intraoperative venous injury Grade 4 Investigations - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Investigations - Other, specifyPTCTCAE E12183 Grade 4 Investigations - Other, specify Grade 4 Iron overload NCILife-threatening consequences; urgent intervention indicated Grade 4 Iron overloadPTCTCAE E12353 Grade 4 Iron overload Grade 4 Jejunal fistula NCILife-threatening consequences; urgent intervention indicated Grade 4 Jejunal fistulaPTCTCAE E10826 Grade 4 Jejunal fistula Grade 4 Jejunal hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Jejunal hemorrhagePTCTCAE E10832 Grade 4 Jejunal hemorrhage Grade 4 Jejunal obstruction NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Jejunal obstructionPTCTCAE E10838 Grade 4 Jejunal obstruction Grade 4 Jejunal perforation NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Jejunal perforationPTCTCAE E10843 Grade 4 Jejunal perforation Grade 4 Jejunal stenosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Jejunal stenosisPTCTCAE E10849 Grade 4 Jejunal stenosis Grade 4 Jejunal ulcer NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Jejunal ulcerPTCTCAE E10855 Grade 4 Jejunal ulcer Grade 4 Joint infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Joint infectionPTCTCAE E11429 Grade 4 Joint infection Grade 4 Keratitis NCIPerforation or blindness (20/200 or worse) in the affected eye Grade 4 KeratitisPTCTCAE E10400 Grade 4 Keratitis Grade 4 Kidney anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Kidney anastomotic leakPTCTCAE E11883 Grade 4 Kidney anastomotic leak Grade 4 Kidney infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Kidney infectionPTCTCAE E11433 Grade 4 Kidney infection Grade 4 Large intestinal anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Large intestinal anastomotic leakPTCTCAE E11889 Grade 4 Large intestinal anastomotic leak Grade 4 Laryngeal edema NCILife-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) Grade 4 Laryngeal edemaPTCTCAE E13397 Grade 4 Laryngeal edema Grade 4 Laryngeal fistula NCILife-threatening consequences; urgent operative intervention indicated (e.g., thoracoplasty, chronic open drainage or multiple thoracotomies) Grade 4 Laryngeal fistulaPTCTCAE E13403 Grade 4 Laryngeal fistula Grade 4 Laryngeal hemorrhage NCILife-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) Grade 4 Laryngeal hemorrhagePTCTCAE E13409 Grade 4 Laryngeal hemorrhage Grade 4 Laryngeal mucositis NCILife-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) Grade 4 Laryngeal mucositisPTCTCAE E13419 Grade 4 Laryngeal mucositis Grade 4 Laryngeal obstruction NCILife-threatening consequences; urgent intervention indicated Grade 4 Laryngeal obstructionPTCTCAE E13425 Grade 4 Laryngeal obstruction Grade 4 Laryngeal stenosis NCILife-threatening consequences; urgent intervention indicated Grade 4 Laryngeal stenosisPTCTCAE E13431 Grade 4 Laryngeal stenosis Grade 4 Laryngitis NCILife-threatening consequences; urgent intervention indicated Grade 4 LaryngitisPTCTCAE E11438 Grade 4 Laryngitis Grade 4 Laryngopharyngeal dysesthesia NCILife-threatening consequences Grade 4 Laryngopharyngeal dysesthesiaPTCTCAE E13437 Grade 4 Laryngopharyngeal dysesthesia Grade 4 Laryngospasm NCIPersistent or severe episodes associated with syncope; urgent intervention indicated (e.g., fiberoptic laryngoscopy, intubation, botox injection) Grade 4 LaryngospasmPTCTCAE E13442 Grade 4 Laryngospasm Grade 4 Left ventricular systolic dysfunction NCIRefractory or poorly controlled heart failure due to drop in ejection fraction; intervention such as ventricular assist device, intravenous vasopressor support, or heart transplant indicated Grade 4 Left ventricular systolic dysfunctionPTCTCAE E10132 Grade 4 Left ventricular systolic dysfunction Grade 4 Leukemia secondary to oncology chemotherapy NCIPresent Grade 4 Leukemia secondary to oncology chemotherapyPTCTCAE E12550 Grade 4 Leukemia secondary to oncology chemotherapy Grade 4 Leukocytosis NCIClinical manifestations of leucostasis; urgent intervention indicated Grade 4 LeukocytosisPTCTCAE E10050 Grade 4 Leukocytosis Grade 4 Leukoencephalopathy NCILife-threatening consequences; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving most of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly Grade 4 LeukoencephalopathyPTCTCAE E12716 Grade 4 Leukoencephalopathy Grade 4 Lipase increased NCI>5.0 x ULN Grade 4 Lipase increasedPTCTCAE E12189 Grade 4 Lipase increased Grade 4 Lower gastrointestinal hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Lower gastrointestinal hemorrhagePTCTCAE E10865 Grade 4 Lower gastrointestinal hemorrhage Grade 4 Lung infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Lung infectionPTCTCAE E11447 Grade 4 Lung infection Grade 4 Lymph gland infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Lymph gland infectionPTCTCAE E11452 Grade 4 Lymph gland infection Grade 4 Lymph leakage NCILife-threatening consequences; urgent intervention indicated Grade 4 Lymph leakagePTCTCAE E13800 Grade 4 Lymph leakage Grade 4 Lymphocyte count decreased NCI<200/mm3; <0.2 x 10e9 /L Grade 4 Lymphocyte count decreasedPTCTCAE E12194 Grade 4 Lymphocyte count decreased Grade 4 Malabsorption NCILife-threatening consequences; urgent intervention indicated Grade 4 MalabsorptionPTCTCAE E10870 Grade 4 Malabsorption Grade 4 Mania NCILife-threatening consequences, threats of harm to self or others; hospitalization indicated Grade 4 ManiaPTCTCAE E12940 Grade 4 Mania Grade 4 Mediastinal hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Mediastinal hemorrhagePTCTCAE E13448 Grade 4 Mediastinal hemorrhage Grade 4 Mediastinal infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Mediastinal infectionPTCTCAE E11456 Grade 4 Mediastinal infection Grade 4 Meningismus NCILife-threatening consequences; urgent intervention indicated Grade 4 MeningismusPTCTCAE E12726 Grade 4 Meningismus Grade 4 Meningitis NCILife-threatening consequences; urgent intervention indicated Grade 4 MeningitisPTCTCAE E11460 Grade 4 Meningitis Grade 4 Menorrhagia NCILife-threatening consequences; urgent intervention indicated Grade 4 MenorrhagiaPTCTCAE E13136 Grade 4 Menorrhagia Grade 4 Metabolism and nutrition disorders - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Metabolism and nutrition disorders - Other, specifyPTCTCAE E12359 Grade 4 Metabolism and nutrition disorders - Other, specify Grade 4 Middle ear inflammation NCILife-threatening consequences; urgent intervention indicated Grade 4 Middle ear inflammationPTCTCAE E10285 Grade 4 Middle ear inflammation Grade 4 Mitral valve disease NCILife-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) Grade 4 Mitral valve diseasePTCTCAE E10138 Grade 4 Mitral valve disease Grade 4 Mobitz type I NCILife-threatening consequences; urgent intervention indicated Grade 4 Mobitz type IPTCTCAE E10150 Grade 4 Mobitz type I Grade 4 Mobitz (type) II atrioventricular block NCILife-threatening consequences; urgent intervention indicated Grade 4 Mobitz (type) II atrioventricular blockPTCTCAE E10144 Grade 4 Mobitz (type) II atrioventricular block Grade 4 Mucosal infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Mucosal infectionPTCTCAE E11466 Grade 4 Mucosal infection Grade 4 Mucositis oral NCILife-threatening consequences; urgent intervention indicated Grade 4 Mucositis oralPTCTCAE E10876 Grade 4 Mucositis oral Grade 4 Multi-organ failure NCILife-threatening consequences (e.g., vasopressor dependent and oliguric or anuric or ischemic colitis or lactic acidosis) Grade 4 Multi-organ failurePTCTCAE E11157 Grade 4 Multi-organ failure Grade 4 Musculoskeletal and connective tissue disorder - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Musculoskeletal and connective tissue disorder - Other, specifyPTCTCAE E12479 Grade 4 Musculoskeletal and connective tissue disorder - Other, specify Grade 4 Myelitis NCILife-threatening consequences; urgent intervention indicated Grade 4 MyelitisPTCTCAE E12736 Grade 4 Myelitis Grade 4 Myelodysplastic syndrome NCILife-threatening consequences; urgent intervention indicated Grade 4 Myelodysplastic syndromePTCTCAE E12553 Grade 4 Myelodysplastic syndrome Grade 4 Myocardial infarction NCILife-threatening consequences; hemodynamically unstable Grade 4 Myocardial infarctionPTCTCAE E10155 Grade 4 Myocardial infarction Grade 4 Myocarditis NCILife-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support) Grade 4 MyocarditisPTCTCAE E10161 Grade 4 Myocarditis Grade 4 Neck soft tissue necrosis NCILife-threatening consequences; urgent intervention indicated Grade 4 Neck soft tissue necrosisPTCTCAE E12500 Grade 4 Neck soft tissue necrosis Grade 4 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specifyPTCTCAE E12559 Grade 4 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify Grade 4 Nervous system disorders - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Nervous system disorders - Other, specifyPTCTCAE E12742 Grade 4 Nervous system disorders - Other, specify Grade 4 Neutrophil count decreased NCI<500/mm3; <0.5 x 10e9 /L Grade 4 Neutrophil count decreasedPTCTCAE E12202 Grade 4 Neutrophil count decreased Grade 4 Night blindness NCIBlindness (20/200 or worse) in the affected eye Grade 4 Night blindnessPTCTCAE E10405 Grade 4 Night blindness Grade 4 Obesity NCIBMI >=40 kg/m2 Grade 4 ObesityPTCTCAE E12364 Grade 4 Obesity Grade 4 Obstruction gastric NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Obstruction gastricPTCTCAE E10886 Grade 4 Obstruction gastric Grade 4 Optic nerve disorder NCIBlindness (20/200 or worse) in the affected eye Grade 4 Optic nerve disorderPTCTCAE E10410 Grade 4 Optic nerve disorder Grade 4 Oral cavity fistula NCILife-threatening consequences; urgent intervention indicated Grade 4 Oral cavity fistulaPTCTCAE E10892 Grade 4 Oral cavity fistula Grade 4 Oral hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Oral hemorrhagePTCTCAE E10902 Grade 4 Oral hemorrhage Grade 4 Osteonecrosis of jaw NCILife-threatening consequences; urgent intervention indicated Grade 4 Osteonecrosis of jawPTCTCAE E12506 Grade 4 Osteonecrosis of jaw Grade 4 Otitis externa NCILife-threatening consequences; urgent intervention indicated Grade 4 Otitis externaPTCTCAE E11475 Grade 4 Otitis externa Grade 4 Otitis media NCILife-threatening consequences; urgent intervention indicated Grade 4 Otitis mediaPTCTCAE E11480 Grade 4 Otitis media Grade 4 Ovarian hemorrhage NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Ovarian hemorrhagePTCTCAE E13149 Grade 4 Ovarian hemorrhage Grade 4 Ovarian infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Ovarian infectionPTCTCAE E11485 Grade 4 Ovarian infection Grade 4 Ovarian rupture NCILife-threatening consequences; urgent intervention indicated Grade 4 Ovarian rupturePTCTCAE E13155 Grade 4 Ovarian rupture Grade 4 Pancreas infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Pancreas infectionPTCTCAE E11489 Grade 4 Pancreas infection Grade 4 Pancreatic anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Pancreatic anastomotic leakPTCTCAE E11895 Grade 4 Pancreatic anastomotic leak Grade 4 Pancreatic duct stenosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Pancreatic duct stenosisPTCTCAE E10912 Grade 4 Pancreatic duct stenosis Grade 4 Pancreatic fistula NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Pancreatic fistulaPTCTCAE E10918 Grade 4 Pancreatic fistula Grade 4 Pancreatic hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Pancreatic hemorrhagePTCTCAE E10924 Grade 4 Pancreatic hemorrhage Grade 4 Pancreatic necrosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Pancreatic necrosisPTCTCAE E10928 Grade 4 Pancreatic necrosis Grade 4 Pancreatitis NCILife-threatening consequences; urgent intervention indicated Grade 4 PancreatitisPTCTCAE E10933 Grade 4 Pancreatitis Grade 4 Papilledema NCIBlindness (20/200 or worse) in the affected eye Grade 4 PapilledemaPTCTCAE E10415 Grade 4 Papilledema Grade 4 Papulopustular rash NCIPapules and/or pustules covering any % BSA, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences Grade 4 Papulopustular rashPTCTCAE E11495 Grade 4 Papulopustular rash Grade 4 Paroxysmal atrial tachycardia NCILife-threatening consequences; incompletely controlled medically; cardioversion indicated Grade 4 Paroxysmal atrial tachycardiaPTCTCAE E10170 Grade 4 Paroxysmal atrial tachycardia Grade 4 Pelvic floor muscle weakness NCILife-threatening consequences; urgent intervention indicated Grade 4 Pelvic floor muscle weaknessPTCTCAE E13165 Grade 4 Pelvic floor muscle weakness Grade 4 Pelvic infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Pelvic infectionPTCTCAE E11504 Grade 4 Pelvic infection Grade 4 Pelvic soft tissue necrosis NCILife-threatening consequences; urgent intervention indicated Grade 4 Pelvic soft tissue necrosisPTCTCAE E12519 Grade 4 Pelvic soft tissue necrosis Grade 4 Penile infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Penile infectionPTCTCAE E11509 Grade 4 Penile infection Grade 4 Perforation bile duct NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Perforation bile ductPTCTCAE E11236 Grade 4 Perforation bile duct Grade 4 Pericardial effusion NCILife-threatening consequences; urgent intervention indicated Grade 4 Pericardial effusionPTCTCAE E10175 Grade 4 Pericardial effusion Grade 4 Pericardial tamponade NCILife-threatening consequences; urgent intervention indicated Grade 4 Pericardial tamponadePTCTCAE E10178 Grade 4 Pericardial tamponade Grade 4 Pericarditis NCILife-threatening consequences; urgent intervention indicated Grade 4 PericarditisPTCTCAE E10184 Grade 4 Pericarditis Grade 4 Periorbital infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Periorbital infectionPTCTCAE E11514 Grade 4 Periorbital infection Grade 4 Peripheral ischemia NCILife-threatening consequences; evidence of end organ damage; urgent operative intervention indicated Grade 4 Peripheral ischemiaPTCTCAE E13813 Grade 4 Peripheral ischemia Grade 4 Peripheral motor neuropathy NCILife-threatening consequences; urgent intervention indicated Grade 4 Peripheral motor neuropathyPTCTCAE E12766 Grade 4 Peripheral motor neuropathy Grade 4 Peripheral nerve infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Peripheral nerve infectionPTCTCAE E11519 Grade 4 Peripheral nerve infection Grade 4 Peripheral sensory neuropathy NCILife-threatening consequences; urgent intervention indicated Grade 4 Peripheral sensory neuropathyPTCTCAE E12772 Grade 4 Peripheral sensory neuropathy Grade 4 Peritoneal infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Peritoneal infectionPTCTCAE E11523 Grade 4 Peritoneal infection Grade 4 Peritoneal necrosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Peritoneal necrosisPTCTCAE E10941 Grade 4 Peritoneal necrosis Grade 4 Personality change NCILife-threatening consequences, threats of harm to self or others; hospitalization indicated Grade 4 Personality changePTCTCAE E12946 Grade 4 Personality change Grade 4 Pharyngeal anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Pharyngeal anastomotic leakPTCTCAE E11901 Grade 4 Pharyngeal anastomotic leak Grade 4 Pharyngeal fistula NCILife-threatening consequences; urgent intervention indicated Grade 4 Pharyngeal fistulaPTCTCAE E13458 Grade 4 Pharyngeal fistula Grade 4 Pharyngeal hemorrhage NCILife-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated Grade 4 Pharyngeal hemorrhagePTCTCAE E13464 Grade 4 Pharyngeal hemorrhage Grade 4 Pharyngeal mucositis NCILife-threatening consequences; urgent intervention indicated Grade 4 Pharyngeal mucositisPTCTCAE E13470 Grade 4 Pharyngeal mucositis Grade 4 Pharyngeal necrosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Pharyngeal necrosisPTCTCAE E13474 Grade 4 Pharyngeal necrosis Grade 4 Pharyngeal stenosis NCILife-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) Grade 4 Pharyngeal stenosisPTCTCAE E13480 Grade 4 Pharyngeal stenosis Grade 4 Pharyngitis NCILife-threatening consequences; urgent intervention indicated Grade 4 PharyngitisPTCTCAE E11528 Grade 4 Pharyngitis Grade 4 Phlebitis infective NCILife-threatening consequences; urgent intervention indicated Grade 4 Phlebitis infectivePTCTCAE E11533 Grade 4 Phlebitis infective Grade 4 Photosensitivity NCILife-threatening consequences; urgent intervention indicated Grade 4 PhotosensitivityPTCTCAE E13684 Grade 4 Photosensitivity Grade 4 Platelet count decreased NCI<25,000/mm3; <25.0 x 10e9 /L Grade 4 Platelet count decreasedPTCTCAE E12211 Grade 4 Platelet count decreased Grade 4 Pleural effusion NCILife-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated Grade 4 Pleural effusionPTCTCAE E13490 Grade 4 Pleural effusion Grade 4 Pleural hemorrhage NCILife-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated Grade 4 Pleural hemorrhagePTCTCAE E13496 Grade 4 Pleural hemorrhage Grade 4 Pleural infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Pleural infectionPTCTCAE E11538 Grade 4 Pleural infection Grade 4 Pneumonitis NCILife-threatening respiratory compromise; urgent intervention indicated (e.g., tracheotomy or intubation) Grade 4 PneumonitisPTCTCAE E13506 Grade 4 Pneumonitis Grade 4 Pneumothorax NCILife-threatening consequences; urgent intervention indicated Grade 4 PneumothoraxPTCTCAE E13512 Grade 4 Pneumothorax Grade 4 Portal hypertension NCILife-threatening consequences; urgent intervention indicated Grade 4 Portal hypertensionPTCTCAE E11241 Grade 4 Portal hypertension Grade 4 Portal vein thrombosis NCILife-threatening consequences; urgent intervention indicated Grade 4 Portal vein thrombosisPTCTCAE E11246 Grade 4 Portal vein thrombosis Grade 4 Postoperative hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Postoperative hemorrhagePTCTCAE E11907 Grade 4 Postoperative hemorrhage Grade 4 Postoperative thoracic procedure complication NCILife-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) Grade 4 Postoperative thoracic procedure complicationPTCTCAE E11912 Grade 4 Postoperative thoracic procedure complication Grade 4 Pregnancy, puerperium and perinatal conditions - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Pregnancy, puerperium and perinatal conditions - Other, specifyPTCTCAE E12865 Grade 4 Pregnancy, puerperium and perinatal conditions - Other, specify Grade 4 Premature delivery NCIDelivery of a liveborn infant at 24 weeks of gestation or less Grade 4 Premature deliveryPTCTCAE E12871 Grade 4 Premature delivery Grade 4 Proctitis NCILife-threatening consequences; urgent intervention indicated Grade 4 ProctitisPTCTCAE E10947 Grade 4 Proctitis Grade 4 Prolapse of intestinal stoma NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Prolapse of intestinal stomaPTCTCAE E11918 Grade 4 Prolapse of intestinal stoma Grade 4 Prolapse of urostomy NCILife-threatening consequences; urgent intervention indicated Grade 4 Prolapse of urostomyPTCTCAE E11924 Grade 4 Prolapse of urostomy Grade 4 Prostate infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Prostate infectionPTCTCAE E11543 Grade 4 Prostate infection Grade 4 Prostatic hemorrhage NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Prostatic hemorrhagePTCTCAE E13185 Grade 4 Prostatic hemorrhage Grade 4 Psychiatric disorders - Other, specify NCILife-threatening consequences; hospitalization or urgent intervention indicated Grade 4 Psychiatric disorders - Other, specifyPTCTCAE E12952 Grade 4 Psychiatric disorders - Other, specify Grade 4 Psychosis NCILife-threatening consequences, threats of harm to self or others; hospitalization indicated Grade 4 PsychosisPTCTCAE E12958 Grade 4 Psychosis Grade 4 Pulmonary edema NCILife-threatening respiratory compromise; urgent intervention or intubation with ventilatory support indicated Grade 4 Pulmonary edemaPTCTCAE E13525 Grade 4 Pulmonary edema Grade 4 Pulmonary fibrosis NCILife-threatening consequences (e.g., hemodynamic/pulmonary complications); intubation with ventilatory support indicated; radiographic pulmonary fibrosis >75% with severe honeycombing Grade 4 Pulmonary fibrosisPTCTCAE E13531 Grade 4 Pulmonary fibrosis Grade 4 Pulmonary fistula NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Pulmonary fistulaPTCTCAE E13537 Grade 4 Pulmonary fistula Grade 4 Pulmonary hypertension NCILife-threatening airway consequences; urgent intervention indicated (e.g., tracheotomy or intubation) Grade 4 Pulmonary hypertensionPTCTCAE E13543 Grade 4 Pulmonary hypertension Grade 4 Pulmonary valve disease NCILife-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) Grade 4 Pulmonary valve diseasePTCTCAE E10190 Grade 4 Pulmonary valve disease Grade 4 Pyramidal tract syndrome NCILife-threatening consequences; urgent intervention indicated Grade 4 Pyramidal tract syndromePTCTCAE E12784 Grade 4 Pyramidal tract syndrome Grade 4 Radiation recall reaction (dermatologic) NCILife-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated Grade 4 Radiation recall reaction (dermatologic)PTCTCAE E11930 Grade 4 Radiation recall reaction (dermatologic) Grade 4 Radiculitis NCILife-threatening consequences; urgent intervention indicated Grade 4 RadiculitisPTCTCAE E12790 Grade 4 Radiculitis Grade 4 Rash acneiform NCIPapules and/or pustules covering any % BSA, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences Grade 4 Rash acneiformPTCTCAE E13698 Grade 4 Rash acneiform Grade 4 Rectal anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Rectal anastomotic leakPTCTCAE E11936 Grade 4 Rectal anastomotic leak Grade 4 Rectal fistula NCILife-threatening consequences; urgent intervention indicated Grade 4 Rectal fistulaPTCTCAE E10953 Grade 4 Rectal fistula Grade 4 Rectal hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Rectal hemorrhagePTCTCAE E10959 Grade 4 Rectal hemorrhage Grade 4 Rectal mucositis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Rectal mucositisPTCTCAE E10965 Grade 4 Rectal mucositis Grade 4 Rectal necrosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Rectal necrosisPTCTCAE E10969 Grade 4 Rectal necrosis Grade 4 Rectal obstruction NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Rectal obstructionPTCTCAE E10975 Grade 4 Rectal obstruction Grade 4 Rectal perforation NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Rectal perforationPTCTCAE E10984 Grade 4 Rectal perforation Grade 4 Rectal stenosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Rectal stenosisPTCTCAE E10990 Grade 4 Rectal stenosis Grade 4 Rectal ulcer NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Rectal ulcerPTCTCAE E10996 Grade 4 Rectal ulcer Grade 4 Recurrent laryngeal nerve palsy NCILife-threatening consequences; urgent intervention indicated Grade 4 Recurrent laryngeal nerve palsyPTCTCAE E12796 Grade 4 Recurrent laryngeal nerve palsy Grade 4 Renal and urinary disorders - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Renal and urinary disorders - Other, specifyPTCTCAE E13016 Grade 4 Renal and urinary disorders - Other, specify Grade 4 Renal calculi NCILife-threatening consequences; urgent radiologic, endoscopic or operative intervention indicated Grade 4 Renal calculiPTCTCAE E13022 Grade 4 Renal calculi Grade 4 Renal hemorrhage NCILife-threatening consequences; urgent radiologic or operative intervention indicated Grade 4 Renal hemorrhagePTCTCAE E13032 Grade 4 Renal hemorrhage Grade 4 Reproductive system and breast disorders - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Reproductive system and breast disorders - Other, specifyPTCTCAE E13199 Grade 4 Reproductive system and breast disorders - Other, specify Grade 4 Respiratory failure NCILife-threatening consequences; urgent intervention, intubation, or ventilatory support indicated Grade 4 Respiratory failurePTCTCAE E13546 Grade 4 Respiratory failure Grade 4 Respiratory, thoracic and mediastinal disorders - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Respiratory, thoracic and mediastinal disorders - Other, specifyPTCTCAE E13552 Grade 4 Respiratory, thoracic and mediastinal disorders - Other, specify Grade 4 Restrictive cardiomyopathy NCIRefractory heart failure or other poorly controlled cardiac symptoms Grade 4 Restrictive cardiomyopathyPTCTCAE E10194 Grade 4 Restrictive cardiomyopathy Grade 4 Retinal detachment NCIBlindness (20/200 or worse) in the affected eye Grade 4 Retinal detachmentPTCTCAE E10424 Grade 4 Retinal detachment Grade 4 Retinal tear NCIBlindness (20/200 or worse) in the affected eye Grade 4 Retinal tearPTCTCAE E10428 Grade 4 Retinal tear Grade 4 Retinoic acid syndrome NCILife-threatening consequences; ventilatory support indicated Grade 4 Retinoic acid syndromePTCTCAE E13558 Grade 4 Retinoic acid syndrome Grade 4 Retinopathy NCIBlindness (20/200 or worse) in the affected eye Grade 4 RetinopathyPTCTCAE E10436 Grade 4 Retinopathy Grade 4 Retroperitoneal hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Retroperitoneal hemorrhagePTCTCAE E11001 Grade 4 Retroperitoneal hemorrhage Grade 4 Reversible posterior leukoencephalopathy syndrome NCILife-threatening consequences; urgent intervention indicated Grade 4 Reversible posterior leukoencephalopathy syndromePTCTCAE E12802 Grade 4 Reversible posterior leukoencephalopathy syndrome Grade 4 Right ventricular dysfunction NCILife-threatening consequences; urgent intervention indicated (e.g., ventricular assist device); heart transplant indicated Grade 4 Right ventricular dysfunctionPTCTCAE E10200 Grade 4 Right ventricular dysfunction Grade 4 Salivary duct inflammation NCILife-threatening consequences; urgent intervention indicated Grade 4 Salivary duct inflammationPTCTCAE E11007 Grade 4 Salivary duct inflammation Grade 4 Salivary gland fistula NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Salivary gland fistulaPTCTCAE E11013 Grade 4 Salivary gland fistula Grade 4 Salivary gland infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Salivary gland infectionPTCTCAE E11553 Grade 4 Salivary gland infection Grade 4 Scleral disorder NCIBlindness (20/200 or worse) in the affected eye Grade 4 Scleral disorderPTCTCAE E10441 Grade 4 Scleral disorder Grade 4 Scrotal infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Scrotal infectionPTCTCAE E11558 Grade 4 Scrotal infection Grade 4 Seizure NCILife-threatening; prolonged repetitive seizures Grade 4 SeizurePTCTCAE E12808 Grade 4 Seizure Grade 4 Sepsis NCILife-threatening consequences; urgent intervention indicated Grade 4 SepsisPTCTCAE E11561 Grade 4 Sepsis Grade 4 Serum amylase increased NCI>5.0 x ULN Grade 4 Serum amylase increasedPTCTCAE E12216 Grade 4 Serum amylase increased Grade 4 Serum sickness NCILife-threatening consequences; pressor or ventilatory support indicated Grade 4 Serum sicknessPTCTCAE E11280 Grade 4 Serum sickness Grade 4 Sick sinus syndrome NCILife-threatening consequences; urgent intervention indicated Grade 4 Sick sinus syndromePTCTCAE E10206 Grade 4 Sick sinus syndrome Grade 4 Sinus bradycardia NCILife-threatening consequences; urgent intervention indicated Grade 4 Sinus bradycardiaPTCTCAE E10212 Grade 4 Sinus bradycardia Grade 4 Sinus disorder NCINecrosis of soft tissue or bone; urgent operative intervention indicated Grade 4 Sinus disorderPTCTCAE E13564 Grade 4 Sinus disorder Grade 4 Sinusitis NCILife-threatening consequences; urgent intervention indicated Grade 4 SinusitisPTCTCAE E11566 Grade 4 Sinusitis Grade 4 Skin and subcutaneous tissue disorders - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Skin and subcutaneous tissue disorders - Other, specifyPTCTCAE E13712 Grade 4 Skin and subcutaneous tissue disorders - Other, specify Grade 4 Skin induration NCIGeneralized; associated with signs or symptoms of impaired breathing or feeding Grade 4 Skin indurationPTCTCAE E13728 Grade 4 Skin induration Grade 4 Skin infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Skin infectionPTCTCAE E11572 Grade 4 Skin infection Grade 4 Skin ulceration NCIAny size ulcer with extensive destruction, tissue necrosis, or damage to muscle, bone, or supporting structures with or without full thickness skin loss Grade 4 Skin ulcerationPTCTCAE E13734 Grade 4 Skin ulceration Grade 4 Sleep apnea NCICardiovascular or neuropsychiatric symptoms; urgent operative intervention indicated Grade 4 Sleep apneaPTCTCAE E13570 Grade 4 Sleep apnea Grade 4 Small intestinal anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Small intestinal anastomotic leakPTCTCAE E11946 Grade 4 Small intestinal anastomotic leak Grade 4 Small intestinal mucositis NCILife-threatening consequences; urgent intervention indicated Grade 4 Small intestinal mucositisPTCTCAE E11019 Grade 4 Small intestinal mucositis Grade 4 Small intestinal obstruction NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Small intestinal obstructionPTCTCAE E11025 Grade 4 Small intestinal obstruction Grade 4 Small intestinal perforation NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Small intestinal perforationPTCTCAE E11030 Grade 4 Small intestinal perforation Grade 4 Small intestinal stenosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Small intestinal stenosisPTCTCAE E11036 Grade 4 Small intestinal stenosis Grade 4 Small intestine infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Small intestine infectionPTCTCAE E11577 Grade 4 Small intestine infection Grade 4 Small intestine ulcer NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Small intestine ulcerPTCTCAE E11042 Grade 4 Small intestine ulcer Grade 4 Social circumstances - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Social circumstances - Other, specifyPTCTCAE E13758 Grade 4 Social circumstances - Other, specify Grade 4 Soft tissue infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Soft tissue infectionPTCTCAE E11582 Grade 4 Soft tissue infection Grade 4 Soft tissue necrosis lower limb NCILife-threatening consequences; urgent intervention indicated Grade 4 Soft tissue necrosis lower limbPTCTCAE E12528 Grade 4 Soft tissue necrosis lower limb Grade 4 Soft tissue necrosis upper limb NCILife-threatening consequences; urgent intervention indicated Grade 4 Soft tissue necrosis upper limbPTCTCAE E12533 Grade 4 Soft tissue necrosis upper limb Grade 4 Somnolence NCILife-threatening consequences; urgent intervention indicated Grade 4 SomnolencePTCTCAE E12818 Grade 4 Somnolence Grade 4 Spasticity NCILife-threatening; unable to move active or passive range of motion Grade 4 SpasticityPTCTCAE E12824 Grade 4 Spasticity Grade 4 Spermatic cord anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Spermatic cord anastomotic leakPTCTCAE E11952 Grade 4 Spermatic cord anastomotic leak Grade 4 Spermatic cord hemorrhage NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Spermatic cord hemorrhagePTCTCAE E13209 Grade 4 Spermatic cord hemorrhage Grade 4 Spinal fracture NCILife-threatening consequences; symptoms associated with neurovascular compromise Grade 4 Spinal fracturePTCTCAE E11958 Grade 4 Spinal fracture Grade 4 Spleen disorder NCILife-threatening consequences; urgent intervention indicated Grade 4 Spleen disorderPTCTCAE E10059 Grade 4 Spleen disorder Grade 4 Splenic infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Splenic infectionPTCTCAE E11586 Grade 4 Splenic infection Grade 4 Stenosis of gastrointestinal stoma NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Stenosis of gastrointestinal stomaPTCTCAE E11963 Grade 4 Stenosis of gastrointestinal stoma Grade 4 Stevens-Johnson syndrome NCISkin sloughing covering 10 - 30% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment) Grade 4 Stevens-Johnson syndromePTCTCAE E13738 Grade 4 Stevens-Johnson syndrome Grade 4 Stoma site infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Stoma site infectionPTCTCAE E11592 Grade 4 Stoma site infection Grade 4 Stridor NCILife-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) Grade 4 StridorPTCTCAE E13581 Grade 4 Stridor Grade 4 Stroke NCILife-threatening consequences; urgent intervention indicated Grade 4 StrokePTCTCAE E12830 Grade 4 Stroke Grade 4 Suicidal ideation NCISpecific plan to commit suicide with serious intent to die which requires hospitalization Grade 4 Suicidal ideationPTCTCAE E12968 Grade 4 Suicidal ideation Grade 4 Suicide attempt NCISuicide attempt with intent to die which requires hospitalization Grade 4 Suicide attemptPTCTCAE E12971 Grade 4 Suicide attempt Grade 4 Superficial soft tissue fibrosis NCIGeneralized; associated with signs or symptoms of impaired breathing or feeding Grade 4 Superficial soft tissue fibrosisPTCTCAE E12539 Grade 4 Superficial soft tissue fibrosis Grade 4 Superior vena cava syndrome NCILife-threatening consequences; urgent multi-modality intervention indicated (e.g., lysis, thrombectomy, surgery) Grade 4 Superior vena cava syndromePTCTCAE E13823 Grade 4 Superior vena cava syndrome Grade 4 Supraventricular tachycardia NCILife-threatening consequences; urgent intervention indicated Grade 4 Supraventricular tachycardiaPTCTCAE E10222 Grade 4 Supraventricular tachycardia Grade 4 Surgical and medical procedures - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Surgical and medical procedures - Other, specifyPTCTCAE E13764 Grade 4 Surgical and medical procedures - Other, specify Grade 4 Testicular disorder NCILife-threatening consequences; urgent intervention indicated Grade 4 Testicular disorderPTCTCAE E13219 Grade 4 Testicular disorder Grade 4 Testicular hemorrhage NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Testicular hemorrhagePTCTCAE E13225 Grade 4 Testicular hemorrhage Grade 4 Thromboembolic event NCILife-threatening (e.g., pulmonary embolism, cerebrovascular event, arterial insufficiency); hemodynamic or neurologic instability; urgent intervention indicated Grade 4 Thromboembolic eventPTCTCAE E13829 Grade 4 Thromboembolic event Grade 4 Thrombotic thrombocytopenic purpura NCILife-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure) Grade 4 Thrombotic thrombocytopenic purpuraPTCTCAE E10064 Grade 4 Thrombotic thrombocytopenic purpura Grade 4 Tooth infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Tooth infectionPTCTCAE E11597 Grade 4 Tooth infection Grade 4 Toxic epidermal necrolysis NCISkin sloughing covering >=30% BSA with associated symptoms (e.g., erythema, purpura, or epidermal detachment) Grade 4 Toxic epidermal necrolysisPTCTCAE E13744 Grade 4 Toxic epidermal necrolysis Grade 4 Tracheal fistula NCILife-threatening consequences; urgent operative intervention indicated (e.g., thoracoplasty, chronic open drainage or multiple thoracotomies) Grade 4 Tracheal fistulaPTCTCAE E13587 Grade 4 Tracheal fistula Grade 4 Tracheal hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Tracheal hemorrhagePTCTCAE E11973 Grade 4 Tracheal hemorrhage Grade 4 Tracheal mucositis NCILife-threatening consequences; urgent intervention indicated Grade 4 Tracheal mucositisPTCTCAE E13593 Grade 4 Tracheal mucositis Grade 4 Tracheal obstruction NCILife-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) Grade 4 Tracheal obstructionPTCTCAE E11979 Grade 4 Tracheal obstruction Grade 4 Tracheal stenosis NCILife-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) Grade 4 Tracheal stenosisPTCTCAE E13599 Grade 4 Tracheal stenosis Grade 4 Tracheitis NCILife-threatening consequences; urgent intervention indicated Grade 4 TracheitisPTCTCAE E11602 Grade 4 Tracheitis Grade 4 Tracheostomy site bleeding NCILife-threatening consequences; urgent intervention indicated Grade 4 Tracheostomy site bleedingPTCTCAE E11985 Grade 4 Tracheostomy site bleeding Grade 4 Treatment related secondary malignancy NCIAcute life-threatening secondary malignancy; blast crisis in leukemia Grade 4 Treatment related secondary malignancyPTCTCAE E12563 Grade 4 Treatment related secondary malignancy Grade 4 Tricuspid valve disease NCILife-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) Grade 4 Tricuspid valve diseasePTCTCAE E10228 Grade 4 Tricuspid valve disease Grade 4 Tumor lysis syndrome NCILife-threatening consequences; urgent intervention indicated Grade 4 Tumor lysis syndromePTCTCAE E12367 Grade 4 Tumor lysis syndrome Grade 4 Typhlitis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 TyphlitisPTCTCAE E11060 Grade 4 Typhlitis Grade 4 Upper gastrointestinal hemorrhage NCILife-threatening consequences; urgent intervention indicated Grade 4 Upper gastrointestinal hemorrhagePTCTCAE E11066 Grade 4 Upper gastrointestinal hemorrhage Grade 4 Upper respiratory infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Upper respiratory infectionPTCTCAE E11607 Grade 4 Upper respiratory infection Grade 4 Ureteric anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Ureteric anastomotic leakPTCTCAE E11991 Grade 4 Ureteric anastomotic leak Grade 4 Urethral anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Urethral anastomotic leakPTCTCAE E11997 Grade 4 Urethral anastomotic leak Grade 4 Urethral infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Urethral infectionPTCTCAE E11612 Grade 4 Urethral infection Grade 4 Urinary fistula NCILife-threatening consequences; urgent radiologic or operative intervention indicated Grade 4 Urinary fistulaPTCTCAE E13037 Grade 4 Urinary fistula Grade 4 Urinary retention NCILife-threatening consequences; organ failure; urgent operative intervention indicated Grade 4 Urinary retentionPTCTCAE E13050 Grade 4 Urinary retention Grade 4 Urinary tract infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Urinary tract infectionPTCTCAE E11617 Grade 4 Urinary tract infection Grade 4 Urinary tract obstruction NCILife-threatening consequences; urgent intervention indicated Grade 4 Urinary tract obstructionPTCTCAE E13056 Grade 4 Urinary tract obstruction Grade 4 Urine output decreased NCIAnuria (<240 ml in 24 hr) Grade 4 Urine output decreasedPTCTCAE E12219 Grade 4 Urine output decreased Grade 4 Urostomy leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Urostomy leakPTCTCAE E12003 Grade 4 Urostomy leak Grade 4 Urostomy obstruction NCILife-threatening consequences; organ failure; urgent operative intervention indicated Grade 4 Urostomy obstructionPTCTCAE E12009 Grade 4 Urostomy obstruction Grade 4 Urostomy site bleeding NCILife-threatening consequences; urgent intervention indicated Grade 4 Urostomy site bleedingPTCTCAE E12015 Grade 4 Urostomy site bleeding Grade 4 Urostomy stenosis NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Urostomy stenosisPTCTCAE E12020 Grade 4 Urostomy stenosis Grade 4 Uterine anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Uterine anastomotic leakPTCTCAE E12026 Grade 4 Uterine anastomotic leak Grade 4 Uterine fistula NCILife-threatening consequences; urgent intervention indicated Grade 4 Uterine fistulaPTCTCAE E13235 Grade 4 Uterine fistula Grade 4 Uterine hemorrhage NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Uterine hemorrhagePTCTCAE E13241 Grade 4 Uterine hemorrhage Grade 4 Uterine infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Uterine infectionPTCTCAE E11622 Grade 4 Uterine infection Grade 4 Uterine perforation NCILife-threatening consequences; urgent intervention indicated Grade 4 Uterine perforationPTCTCAE E12032 Grade 4 Uterine perforation Grade 4 Uveitis NCIBlindness (20/200 or worse) in the affected eye Grade 4 UveitisPTCTCAE E10446 Grade 4 Uveitis Grade 4 Vaginal anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Vaginal anastomotic leakPTCTCAE E12038 Grade 4 Vaginal anastomotic leak Grade 4 Vaginal fistula NCILife-threatening consequences; urgent intervention indicated Grade 4 Vaginal fistulaPTCTCAE E13262 Grade 4 Vaginal fistula Grade 4 Vaginal hemorrhage NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Vaginal hemorrhagePTCTCAE E13268 Grade 4 Vaginal hemorrhage Grade 4 Vaginal infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Vaginal infectionPTCTCAE E11627 Grade 4 Vaginal infection Grade 4 Vaginal inflammation NCIWidespread areas of mucosal ulceration; life-threatening consequences; urgent intervention indicated Grade 4 Vaginal inflammationPTCTCAE E13274 Grade 4 Vaginal inflammation Grade 4 Vaginal perforation NCILife-threatening consequences; urgent intervention indicated Grade 4 Vaginal perforationPTCTCAE E13288 Grade 4 Vaginal perforation Grade 4 Vagus nerve disorder NCILife-threatening consequences; urgent intervention indicated Grade 4 Vagus nerve disorderPTCTCAE E12849 Grade 4 Vagus nerve disorder Grade 4 Vas deferens anastomotic leak NCILife-threatening consequences; urgent operative intervention indicated Grade 4 Vas deferens anastomotic leakPTCTCAE E12044 Grade 4 Vas deferens anastomotic leak Grade 4 Vascular access complication NCIEmbolic event including pulmonary embolism or life-threatening thrombus Grade 4 Vascular access complicationPTCTCAE E12049 Grade 4 Vascular access complication Grade 4 Vascular disorders - Other, specify NCILife-threatening consequences; urgent intervention indicated Grade 4 Vascular disorders - Other, specifyPTCTCAE E13835 Grade 4 Vascular disorders - Other, specify Grade 4 Vasculitis NCILife-threatening; evidence of peripheral or visceral ischemia; urgent intervention indicated Grade 4 VasculitisPTCTCAE E13841 Grade 4 Vasculitis Grade 4 Vasovagal reaction NCILife-threatening consequences; urgent intervention indicated Grade 4 Vasovagal reactionPTCTCAE E12853 Grade 4 Vasovagal reaction Grade 4 Venous injury NCILife-threatening consequences; evidence of end organ damage; urgent operative intervention indicated Grade 4 Venous injuryPTCTCAE E12055 Grade 4 Venous injury Grade 4 Ventricular arrhythmia NCILife-threatening consequences; hemodynamic compromise; urgent intervention indicated Grade 4 Ventricular arrhythmiaPTCTCAE E10234 Grade 4 Ventricular arrhythmia Grade 4 Ventricular fibrillation NCILife-threatening consequences; hemodynamic compromise; urgent intervention indicated Grade 4 Ventricular fibrillationPTCTCAE E10237 Grade 4 Ventricular fibrillation Grade 4 Ventricular tachycardia NCILife-threatening consequences; hemodynamic compromise; urgent intervention indicated Grade 4 Ventricular tachycardiaPTCTCAE E10242 Grade 4 Ventricular tachycardia Grade 4 Visceral arterial ischemia NCILife-threatening consequences; evidence of end organ damage; urgent operative intervention indicated Grade 4 Visceral arterial ischemiaPTCTCAE E13846 Grade 4 Visceral arterial ischemia Grade 4 Vitreous hemorrhage NCIBlindness (20/200 or worse) in the affected eye Grade 4 Vitreous hemorrhagePTCTCAE E10451 Grade 4 Vitreous hemorrhage Grade 4 Vomiting NCILife-threatening consequences; urgent intervention indicated Grade 4 VomitingPTCTCAE E11072 Grade 4 Vomiting Grade 4 Vulval infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Vulval infectionPTCTCAE E11633 Grade 4 Vulval infection Grade 4 Wheezing NCILife-threatening consequences; urgent intervention indicated Grade 4 WheezingPTCTCAE E13609 Grade 4 Wheezing Grade 4 White blood cell decreased NCI<1000/mm3; <1.0 x 10e9 /L Grade 4 White blood cell decreasedPTCTCAE E12236 Grade 4 White blood cell decreased Grade 4 Wolff-Parkinson-White syndrome NCILife-threatening consequences; urgent intervention indicated Grade 4 Wolff-Parkinson-White syndromePTCTCAE E10248 Grade 4 Wolff-Parkinson-White syndrome Grade 4 Wound complication NCIHernia with evidence of strangulation; major reconstruction flap, grafting, resection, or amputation indicated Grade 4 Wound complicationPTCTCAE E12061 Grade 4 Wound complication Grade 4 Wound dehiscence NCILife-threatening consequences; symptomatic hernia with evidence of strangulation; fascial disruption with evisceration; major reconstruction flap, grafting, resection, or amputation indicated Grade 4 Wound dehiscencePTCTCAE E12067 Grade 4 Wound dehiscence Grade 4 Wound infection NCILife-threatening consequences; urgent intervention indicated Grade 4 Wound infectionPTCTCAE E11638 Grade 4 Wound infection Grade 5 Abdominal infection NCIDeath Grade 5 Abdominal infectionPTCTCAE E11285 Grade 5 Abdominal infection Grade 5 Abdominal soft tissue necrosis NCIDeath Grade 5 Abdominal soft tissue necrosisPTCTCAE E12373 Grade 5 Abdominal soft tissue necrosis Grade 5 Acidosis NCIDeath Grade 5 AcidosisPTCTCAE E12241 Grade 5 Acidosis Grade 5 Acute coronary syndrome NCIDeath Grade 5 Acute coronary syndromePTCTCAE E10070 Grade 5 Acute coronary syndrome Grade 5 Acute kidney injury NCIDeath Grade 5 Acute kidney injuryPTCTCAE E12978 Grade 5 Acute kidney injury Grade 5 Adrenal insufficiency NCIDeath Grade 5 Adrenal insufficiencyPTCTCAE E10303 Grade 5 Adrenal insufficiency Grade 5 Adult respiratory distress syndrome NCIDeath Grade 5 Adult respiratory distress syndromePTCTCAE E13302 Grade 5 Adult respiratory distress syndrome Grade 5 Adverse Event NCIDeath. Fatal Adverse EventSYCTCAE Grade 5 Adverse EventPTCTCAE E10009 Grade 5 Adverse Event Grade 5 Agitation NCIDeath Grade 5 AgitationPTCTCAE E12879 Grade 5 Agitation Grade 5 Alcohol intolerance NCIDeath Grade 5 Alcohol intolerancePTCTCAE E12246 Grade 5 Alcohol intolerance Grade 5 Alkalosis NCIDeath Grade 5 AlkalosisPTCTCAE E12251 Grade 5 Alkalosis Grade 5 Allergic reaction NCIDeath Grade 5 Allergic reactionPTCTCAE E11253 Grade 5 Allergic reaction Grade 5 Anal fistula NCIDeath Grade 5 Anal fistulaPTCTCAE E10469 Grade 5 Anal fistula Grade 5 Anal hemorrhage NCIDeath Grade 5 Anal hemorrhagePTCTCAE E10475 Grade 5 Anal hemorrhage Grade 5 Anal mucositis NCIDeath Grade 5 Anal mucositisPTCTCAE E10481 Grade 5 Anal mucositis Grade 5 Anal necrosis NCIDeath Grade 5 Anal necrosisPTCTCAE E10485 Grade 5 Anal necrosis Grade 5 Anal stenosis NCIDeath Grade 5 Anal stenosisPTCTCAE E10495 Grade 5 Anal stenosis Grade 5 Anal ulcer NCIDeath Grade 5 Anal ulcerPTCTCAE E10501 Grade 5 Anal ulcer Grade 5 Anaphylaxis NCIDeath Grade 5 AnaphylaxisPTCTCAE E11257 Grade 5 Anaphylaxis Grade 5 Anemia NCIDeath Grade 5 AnemiaPTCTCAE E10015 Grade 5 Anemia Grade 5 Anorectal infection NCIDeath Grade 5 Anorectal infectionPTCTCAE E11291 Grade 5 Anorectal infection Grade 5 Anorexia NCIDeath Grade 5 AnorexiaPTCTCAE E12257 Grade 5 Anorexia Grade 5 Anxiety NCIDeath Grade 5 AnxietyPTCTCAE E12888 Grade 5 Anxiety Grade 5 Aortic injury NCIDeath Grade 5 Aortic injuryPTCTCAE E11647 Grade 5 Aortic injury Grade 5 Aortic valve disease NCIDeath Grade 5 Aortic valve diseasePTCTCAE E10076 Grade 5 Aortic valve disease Grade 5 Apnea NCIDeath Grade 5 ApneaPTCTCAE E13309 Grade 5 Apnea Grade 5 Appendicitis NCIDeath Grade 5 AppendicitisPTCTCAE E11295 Grade 5 Appendicitis Grade 5 Appendicitis perforated NCIDeath Grade 5 Appendicitis perforatedPTCTCAE E11300 Grade 5 Appendicitis perforated Grade 5 Arachnoiditis NCIDeath Grade 5 ArachnoiditisPTCTCAE E12596 Grade 5 Arachnoiditis Grade 5 Arterial injury NCIDeath Grade 5 Arterial injuryPTCTCAE E11653 Grade 5 Arterial injury Grade 5 Arteritis infective NCIDeath Grade 5 Arteritis infectivePTCTCAE E11304 Grade 5 Arteritis infective Grade 5 Ascites NCIDeath Grade 5 AscitesPTCTCAE E10507 Grade 5 Ascites Grade 5 Aspiration NCIDeath Grade 5 AspirationPTCTCAE E13315 Grade 5 Aspiration Grade 5 Asystole NCIDeath Grade 5 AsystolePTCTCAE E10080 Grade 5 Asystole Grade 5 Atelectasis NCIDeath Grade 5 AtelectasisPTCTCAE E13321 Grade 5 Atelectasis Grade 5 Atrial fibrillation NCIDeath Grade 5 Atrial fibrillationPTCTCAE E10086 Grade 5 Atrial fibrillation Grade 5 Atrial flutter NCIDeath Grade 5 Atrial flutterPTCTCAE E10092 Grade 5 Atrial flutter Grade 5 Atrioventricular block complete NCIDeath Grade 5 Atrioventricular block completePTCTCAE E10097 Grade 5 Atrioventricular block complete Grade 5 Autoimmune disorder NCIDeath Grade 5 Autoimmune disorderPTCTCAE E11263 Grade 5 Autoimmune disorder Grade 5 Avascular necrosis NCIDeath Grade 5 Avascular necrosisPTCTCAE E12387 Grade 5 Avascular necrosis Grade 5 Bile duct stenosis NCIDeath Grade 5 Bile duct stenosisPTCTCAE E11178 Grade 5 Bile duct stenosis Grade 5 Biliary anastomotic leak NCIDeath Grade 5 Biliary anastomotic leakPTCTCAE E11659 Grade 5 Biliary anastomotic leak Grade 5 Biliary fistula NCIDeath Grade 5 Biliary fistulaPTCTCAE E11183 Grade 5 Biliary fistula Grade 5 Biliary tract infection NCIDeath Grade 5 Biliary tract infectionPTCTCAE E11308 Grade 5 Biliary tract infection Grade 5 Bladder anastomotic leak NCIDeath Grade 5 Bladder anastomotic leakPTCTCAE E11665 Grade 5 Bladder anastomotic leak Grade 5 Bladder infection NCIDeath Grade 5 Bladder infectionPTCTCAE E11313 Grade 5 Bladder infection Grade 5 Bladder perforation NCIDeath Grade 5 Bladder perforationPTCTCAE E12983 Grade 5 Bladder perforation Grade 5 Blood and lymphatic system disorders - Other, specify NCIDeath Grade 5 Blood and lymphatic system disorders - Other, specifyPTCTCAE E10021 Grade 5 Blood and lymphatic system disorders - Other, specify Grade 5 Bone infection NCIDeath Grade 5 Bone infectionPTCTCAE E11317 Grade 5 Bone infection Grade 5 Bone marrow hypocellular NCIDeath Grade 5 Bone marrow hypocellularPTCTCAE E10027 Grade 5 Bone marrow hypocellular Grade 5 Breast infection NCIDeath Grade 5 Breast infectionPTCTCAE E11322 Grade 5 Breast infection Grade 5 Bronchial fistula NCIDeath Grade 5 Bronchial fistulaPTCTCAE E13327 Grade 5 Bronchial fistula Grade 5 Bronchial infection NCIDeath Grade 5 Bronchial infectionPTCTCAE E11327 Grade 5 Bronchial infection Grade 5 Bronchial obstruction NCIDeath Grade 5 Bronchial obstructionPTCTCAE E13333 Grade 5 Bronchial obstruction Grade 5 Bronchial stricture NCIDeath Grade 5 Bronchial stricturePTCTCAE E13339 Grade 5 Bronchial stricture Grade 5 Bronchopleural fistula NCIDeath Grade 5 Bronchopleural fistulaPTCTCAE E13345 Grade 5 Bronchopleural fistula Grade 5 Bronchopulmonary hemorrhage NCIDeath Grade 5 Bronchopulmonary hemorrhagePTCTCAE E13351 Grade 5 Bronchopulmonary hemorrhage Grade 5 Bronchospasm NCIDeath Grade 5 BronchospasmPTCTCAE E13357 Grade 5 Bronchospasm Grade 5 Bullous dermatitis NCIDeath Grade 5 Bullous dermatitisPTCTCAE E13622 Grade 5 Bullous dermatitis Grade 5 Burn NCIDeath Grade 5 BurnPTCTCAE E11674 Grade 5 Burn Grade 5 Capillary leak syndrome NCIDeath Grade 5 Capillary leak syndromePTCTCAE E13770 Grade 5 Capillary leak syndrome Grade 5 Cardiac arrest NCIDeath Grade 5 Cardiac arrestPTCTCAE E10103 Grade 5 Cardiac arrest Grade 5 Cardiac disorders - Other, specify NCIDeath Grade 5 Cardiac disorders - Other, specifyPTCTCAE E10109 Grade 5 Cardiac disorders - Other, specify Grade 5 Catheter related infection NCIDeath Grade 5 Catheter related infectionPTCTCAE E11332 Grade 5 Catheter related infection Grade 5 Cecal hemorrhage NCIDeath Grade 5 Cecal hemorrhagePTCTCAE E10516 Grade 5 Cecal hemorrhage Grade 5 Cecal infection NCIDeath Grade 5 Cecal infectionPTCTCAE E11336 Grade 5 Cecal infection Grade 5 Central nervous system necrosis NCIDeath Grade 5 Central nervous system necrosisPTCTCAE E12610 Grade 5 Central nervous system necrosis Grade 5 Cerebrospinal fluid leakage NCIDeath Grade 5 Cerebrospinal fluid leakagePTCTCAE E12616 Grade 5 Cerebrospinal fluid leakage Grade 5 Cervicitis infection NCIDeath Grade 5 Cervicitis infectionPTCTCAE E11341 Grade 5 Cervicitis infection Grade 5 Cholecystitis NCIDeath Grade 5 CholecystitisPTCTCAE E11188 Grade 5 Cholecystitis Grade 5 Chronic kidney disease NCIDeath Grade 5 Chronic kidney diseasePTCTCAE E12993 Grade 5 Chronic kidney disease Grade 5 Chylothorax NCIDeath Grade 5 ChylothoraxPTCTCAE E13363 Grade 5 Chylothorax Grade 5 Colitis NCIDeath Grade 5 ColitisPTCTCAE E10526 Grade 5 Colitis Grade 5 Colonic fistula NCIDeath Grade 5 Colonic fistulaPTCTCAE E10532 Grade 5 Colonic fistula Grade 5 Colonic hemorrhage NCIDeath Grade 5 Colonic hemorrhagePTCTCAE E10538 Grade 5 Colonic hemorrhage Grade 5 Colonic obstruction NCIDeath Grade 5 Colonic obstructionPTCTCAE E10544 Grade 5 Colonic obstruction Grade 5 Colonic perforation NCIDeath Grade 5 Colonic perforationPTCTCAE E10549 Grade 5 Colonic perforation Grade 5 Colonic stenosis NCIDeath Grade 5 Colonic stenosisPTCTCAE E10555 Grade 5 Colonic stenosis Grade 5 Colonic ulcer NCIDeath Grade 5 Colonic ulcerPTCTCAE E10561 Grade 5 Colonic ulcer Grade 5 Conduction disorder NCIDeath Grade 5 Conduction disorderPTCTCAE E10119 Grade 5 Conduction disorder Grade 5 Confusion NCIDeath Grade 5 ConfusionPTCTCAE E12894 Grade 5 Confusion Grade 5 Congenital, familial and genetic disorders - Other, specify NCIDeath Grade 5 Congenital, familial and genetic disorders - Other, specifyPTCTCAE E10255 Grade 5 Congenital, familial and genetic disorders - Other, specify Grade 5 Conjunctivitis infective NCIDeath Grade 5 Conjunctivitis infectivePTCTCAE E11346 Grade 5 Conjunctivitis infective Grade 5 Constipation NCIDeath Grade 5 ConstipationPTCTCAE E10567 Grade 5 Constipation Grade 5 Constrictive pericarditis NCIDeath Grade 5 Constrictive pericarditisPTCTCAE E10123 Grade 5 Constrictive pericarditis Grade 5 Corneal infection NCIDeath Grade 5 Corneal infectionPTCTCAE E11351 Grade 5 Corneal infection Grade 5 Cranial nerve infection NCIDeath Grade 5 Cranial nerve infectionPTCTCAE E11355 Grade 5 Cranial nerve infection Grade 5 Cystitis noninfective NCIDeath Grade 5 Cystitis noninfectivePTCTCAE E12999 Grade 5 Cystitis noninfective Grade 5 Cytokine release syndrome NCIDeath Grade 5 Cytokine release syndromePTCTCAE E11269 Grade 5 Cytokine release syndrome Grade 5 Death NOS NCIDeath Grade 5 Death NOSPTCTCAE E11081 Grade 5 Death NOS Grade 5 Death neonatal NCIDeath Grade 5 Death neonatalPTCTCAE E11079 Grade 5 Death neonatal Grade 5 Dehydration NCIDeath Grade 5 DehydrationPTCTCAE E12263 Grade 5 Dehydration Grade 5 Delirium NCIDeath Grade 5 DeliriumPTCTCAE E12903 Grade 5 Delirium Grade 5 Delusions NCIDeath Grade 5 DelusionsPTCTCAE E12908 Grade 5 Delusions Grade 5 Depressed level of consciousness NCIDeath Grade 5 Depressed level of consciousnessPTCTCAE E12630 Grade 5 Depressed level of consciousness Grade 5 Depression NCIDeath Grade 5 DepressionPTCTCAE E12914 Grade 5 Depression Grade 5 Dermatitis radiation NCIDeath Grade 5 Dermatitis radiationPTCTCAE E11680 Grade 5 Dermatitis radiation Grade 5 Device related infection NCIDeath Grade 5 Device related infectionPTCTCAE E11359 Grade 5 Device related infection Grade 5 Diarrhea NCIDeath Grade 5 DiarrheaPTCTCAE E10577 Grade 5 Diarrhea Grade 5 Disseminated intravascular coagulation NCIDeath Grade 5 Disseminated intravascular coagulationPTCTCAE E10032 Grade 5 Disseminated intravascular coagulation Grade 5 Duodenal fistula NCIDeath Grade 5 Duodenal fistulaPTCTCAE E10587 Grade 5 Duodenal fistula Grade 5 Duodenal hemorrhage NCIDeath Grade 5 Duodenal hemorrhagePTCTCAE E10593 Grade 5 Duodenal hemorrhage Grade 5 Duodenal infection NCIDeath Grade 5 Duodenal infectionPTCTCAE E11364 Grade 5 Duodenal infection Grade 5 Duodenal obstruction NCIDeath Grade 5 Duodenal obstructionPTCTCAE E10599 Grade 5 Duodenal obstruction Grade 5 Duodenal perforation NCIDeath Grade 5 Duodenal perforationPTCTCAE E10604 Grade 5 Duodenal perforation Grade 5 Duodenal stenosis NCIDeath Grade 5 Duodenal stenosisPTCTCAE E10610 Grade 5 Duodenal stenosis Grade 5 Duodenal ulcer NCIDeath Grade 5 Duodenal ulcerPTCTCAE E10616 Grade 5 Duodenal ulcer Grade 5 Dysphagia NCIDeath Grade 5 DysphagiaPTCTCAE E10626 Grade 5 Dysphagia Grade 5 Dyspnea NCIDeath Grade 5 DyspneaPTCTCAE E13373 Grade 5 Dyspnea Grade 5 Ear and labyrinth disorders - Other, specify NCIDeath Grade 5 Ear and labyrinth disorders - Other, specifyPTCTCAE E10261 Grade 5 Ear and labyrinth disorders - Other, specify Grade 5 Encephalitis infection NCIDeath Grade 5 Encephalitis infectionPTCTCAE E11368 Grade 5 Encephalitis infection Grade 5 Encephalomyelitis infection NCIDeath Grade 5 Encephalomyelitis infectionPTCTCAE E11372 Grade 5 Encephalomyelitis infection Grade 5 Encephalopathy NCIDeath Grade 5 EncephalopathyPTCTCAE E12657 Grade 5 Encephalopathy Grade 5 Endocarditis infective NCIDeath Grade 5 Endocarditis infectivePTCTCAE E11376 Grade 5 Endocarditis infective Grade 5 Endocrine disorders - Other, specify NCIDeath Grade 5 Endocrine disorders - Other, specifyPTCTCAE E10316 Grade 5 Endocrine disorders - Other, specify Grade 5 Enterocolitis NCIDeath Grade 5 EnterocolitisPTCTCAE E10632 Grade 5 Enterocolitis Grade 5 Enterocolitis infectious NCIDeath Grade 5 Enterocolitis infectiousPTCTCAE E11385 Grade 5 Enterocolitis infectious Grade 5 Enterovesical fistula NCIDeath Grade 5 Enterovesical fistulaPTCTCAE E10638 Grade 5 Enterovesical fistula Grade 5 Epistaxis NCIDeath Grade 5 EpistaxisPTCTCAE E13379 Grade 5 Epistaxis Grade 5 Erythema multiforme NCIDeath Grade 5 Erythema multiformePTCTCAE E13632 Grade 5 Erythema multiforme Grade 5 Erythroderma NCIDeath Grade 5 ErythrodermaPTCTCAE E13637 Grade 5 Erythroderma Grade 5 Esophageal anastomotic leak NCIDeath Grade 5 Esophageal anastomotic leakPTCTCAE E11686 Grade 5 Esophageal anastomotic leak Grade 5 Esophageal fistula NCIDeath Grade 5 Esophageal fistulaPTCTCAE E10644 Grade 5 Esophageal fistula Grade 5 Esophageal hemorrhage NCIDeath Grade 5 Esophageal hemorrhagePTCTCAE E10650 Grade 5 Esophageal hemorrhage Grade 5 Esophageal infection NCIDeath Grade 5 Esophageal infectionPTCTCAE E11390 Grade 5 Esophageal infection Grade 5 Esophageal necrosis NCIDeath Grade 5 Esophageal necrosisPTCTCAE E10654 Grade 5 Esophageal necrosis Grade 5 Esophageal obstruction NCIDeath Grade 5 Esophageal obstructionPTCTCAE E10660 Grade 5 Esophageal obstruction Grade 5 Esophageal perforation NCIDeath Grade 5 Esophageal perforationPTCTCAE E10669 Grade 5 Esophageal perforation Grade 5 Esophageal stenosis NCIDeath Grade 5 Esophageal stenosisPTCTCAE E10675 Grade 5 Esophageal stenosis Grade 5 Esophageal ulcer NCIDeath Grade 5 Esophageal ulcerPTCTCAE E10681 Grade 5 Esophageal ulcer Grade 5 Esophageal varices hemorrhage NCIDeath Grade 5 Esophageal varices hemorrhagePTCTCAE E10686 Grade 5 Esophageal varices hemorrhage Grade 5 Esophagitis NCIDeath Grade 5 EsophagitisPTCTCAE E10692 Grade 5 Esophagitis Grade 5 External ear inflammation NCIDeath Grade 5 External ear inflammationPTCTCAE E10271 Grade 5 External ear inflammation Grade 5 Extrapyramidal disorder NCIDeath Grade 5 Extrapyramidal disorderPTCTCAE E12663 Grade 5 Extrapyramidal disorder Grade 5 Eye infection NCIDeath Grade 5 Eye infectionPTCTCAE E11395 Grade 5 Eye infection Grade 5 Fallopian tube anastomotic leak NCIDeath Grade 5 Fallopian tube anastomotic leakPTCTCAE E11696 Grade 5 Fallopian tube anastomotic leak Grade 5 Fallopian tube perforation NCIDeath Grade 5 Fallopian tube perforationPTCTCAE E11702 Grade 5 Fallopian tube perforation Grade 5 Fallopian tube stenosis NCIDeath Grade 5 Fallopian tube stenosisPTCTCAE E13101 Grade 5 Fallopian tube stenosis Grade 5 Febrile neutropenia NCIDeath Grade 5 Febrile neutropeniaPTCTCAE E10036 Grade 5 Febrile neutropenia Grade 5 Female genital tract fistula NCIDeath Grade 5 Female genital tract fistulaPTCTCAE E13107 Grade 5 Female genital tract fistula Grade 5 Fetal death NCIFetal loss at any gestational age Grade 5 Fetal deathPTCTCAE E12856 Grade 5 Fetal death Grade 5 Fever NCIDeath Grade 5 FeverPTCTCAE E11107 Grade 5 Fever Grade 5 Fibrosis deep connective tissue NCIDeath Grade 5 Fibrosis deep connective tissuePTCTCAE E12413 Grade 5 Fibrosis deep connective tissue Grade 5 Fracture NCIDeath Grade 5 FracturePTCTCAE E11708 Grade 5 Fracture Grade 5 Gallbladder fistula NCIDeath Grade 5 Gallbladder fistulaPTCTCAE E11194 Grade 5 Gallbladder fistula Grade 5 Gallbladder infection NCIDeath Grade 5 Gallbladder infectionPTCTCAE E11399 Grade 5 Gallbladder infection Grade 5 Gallbladder necrosis NCIDeath Grade 5 Gallbladder necrosisPTCTCAE E11197 Grade 5 Gallbladder necrosis Grade 5 Gallbladder obstruction NCIDeath Grade 5 Gallbladder obstructionPTCTCAE E11203 Grade 5 Gallbladder obstruction Grade 5 Gallbladder perforation NCIDeath Grade 5 Gallbladder perforationPTCTCAE E11210 Grade 5 Gallbladder perforation Grade 5 Gastric anastomotic leak NCIDeath Grade 5 Gastric anastomotic leakPTCTCAE E11714 Grade 5 Gastric anastomotic leak Grade 5 Gastric fistula NCIDeath Grade 5 Gastric fistulaPTCTCAE E10705 Grade 5 Gastric fistula Grade 5 Gastric hemorrhage NCIDeath Grade 5 Gastric hemorrhagePTCTCAE E10711 Grade 5 Gastric hemorrhage Grade 5 Gastric necrosis NCIDeath Grade 5 Gastric necrosisPTCTCAE E10715 Grade 5 Gastric necrosis Grade 5 Gastric perforation NCIDeath Grade 5 Gastric perforationPTCTCAE E10720 Grade 5 Gastric perforation Grade 5 Gastric stenosis NCIDeath Grade 5 Gastric stenosisPTCTCAE E10726 Grade 5 Gastric stenosis Grade 5 Gastric ulcer NCIDeath Grade 5 Gastric ulcerPTCTCAE E10732 Grade 5 Gastric ulcer Grade 5 Gastritis NCIDeath Grade 5 GastritisPTCTCAE E10738 Grade 5 Gastritis Grade 5 Gastrointestinal anastomotic leak NCIDeath Grade 5 Gastrointestinal anastomotic leakPTCTCAE E11720 Grade 5 Gastrointestinal anastomotic leak Grade 5 Gastrointestinal disorders - Other, specify NCIDeath Grade 5 Gastrointestinal disorders - Other, specifyPTCTCAE E10748 Grade 5 Gastrointestinal disorders - Other, specify Grade 5 Gastrointestinal fistula NCIDeath Grade 5 Gastrointestinal fistulaPTCTCAE E10754 Grade 5 Gastrointestinal fistula Grade 5 Gastrointestinal stoma necrosis NCIDeath Grade 5 Gastrointestinal stoma necrosisPTCTCAE E11725 Grade 5 Gastrointestinal stoma necrosis Grade 5 General disorders and administration site conditions - Other, specify NCIDeath Grade 5 General disorders and administration site conditions - Other, specifyPTCTCAE E11121 Grade 5 General disorders and administration site conditions - Other, specify Grade 5 Glossopharyngeal nerve disorder NCIDeath Grade 5 Glossopharyngeal nerve disorderPTCTCAE E12677 Grade 5 Glossopharyngeal nerve disorder Grade 5 Glucose intolerance NCIDeath Grade 5 Glucose intolerancePTCTCAE E12269 Grade 5 Glucose intolerance Grade 5 Gum infection NCIDeath Grade 5 Gum infectionPTCTCAE E11405 Grade 5 Gum infection Grade 5 Hallucinations NCIDeath Grade 5 HallucinationsPTCTCAE E12924 Grade 5 Hallucinations Grade 5 Head soft tissue necrosis NCIDeath Grade 5 Head soft tissue necrosisPTCTCAE E12430 Grade 5 Head soft tissue necrosis Grade 5 Heart failure NCIDeath Grade 5 Heart failurePTCTCAE E10129 Grade 5 Heart failure Grade 5 Hematoma NCIDeath Grade 5 HematomaPTCTCAE E13780 Grade 5 Hematoma Grade 5 Hematosalpinx NCIDeath Grade 5 HematosalpinxPTCTCAE E13124 Grade 5 Hematosalpinx Grade 5 Hematuria NCIDeath Grade 5 HematuriaPTCTCAE E13005 Grade 5 Hematuria Grade 5 Hemolysis NCIDeath Grade 5 HemolysisPTCTCAE E10042 Grade 5 Hemolysis Grade 5 Hemolytic uremic syndrome NCIDeath Grade 5 Hemolytic uremic syndromePTCTCAE E10047 Grade 5 Hemolytic uremic syndrome Grade 5 Hemorrhoidal hemorrhage NCIDeath Grade 5 Hemorrhoidal hemorrhagePTCTCAE E10772 Grade 5 Hemorrhoidal hemorrhage Grade 5 Hepatic failure NCIDeath Grade 5 Hepatic failurePTCTCAE E11214 Grade 5 Hepatic failure Grade 5 Hepatic hemorrhage NCIDeath Grade 5 Hepatic hemorrhagePTCTCAE E11220 Grade 5 Hepatic hemorrhage Grade 5 Hepatic infection NCIDeath Grade 5 Hepatic infectionPTCTCAE E11409 Grade 5 Hepatic infection Grade 5 Hepatic necrosis NCIDeath Grade 5 Hepatic necrosisPTCTCAE E11223 Grade 5 Hepatic necrosis Grade 5 Hepatitis viral NCIDeath Grade 5 Hepatitis viralPTCTCAE E11414 Grade 5 Hepatitis viral Grade 5 Hepatobiliary disorders - Other, specify NCIDeath Grade 5 Hepatobiliary disorders - Other, specifyPTCTCAE E11233 Grade 5 Hepatobiliary disorders - Other, specify Grade 5 Hydrocephalus NCIDeath Grade 5 HydrocephalusPTCTCAE E12687 Grade 5 Hydrocephalus Grade 5 Hypercalcemia NCIDeath Grade 5 HypercalcemiaPTCTCAE E12275 Grade 5 Hypercalcemia Grade 5 Hyperglycemia NCIDeath Grade 5 HyperglycemiaPTCTCAE E12281 Grade 5 Hyperglycemia Grade 5 Hyperkalemia NCIDeath Grade 5 HyperkalemiaPTCTCAE E12287 Grade 5 Hyperkalemia Grade 5 Hypermagnesemia NCIDeath Grade 5 HypermagnesemiaPTCTCAE E12292 Grade 5 Hypermagnesemia Grade 5 Hypernatremia NCIDeath Grade 5 HypernatremiaPTCTCAE E12298 Grade 5 Hypernatremia Grade 5 Hypertension NCIDeath Grade 5 HypertensionPTCTCAE E13790 Grade 5 Hypertension Grade 5 Hyperthyroidism NCIDeath Grade 5 HyperthyroidismPTCTCAE E10327 Grade 5 Hyperthyroidism Grade 5 Hypertriglyceridemia NCIDeath Grade 5 HypertriglyceridemiaPTCTCAE E12304 Grade 5 Hypertriglyceridemia Grade 5 Hyperuricemia NCIDeath Grade 5 HyperuricemiaPTCTCAE E12309 Grade 5 Hyperuricemia Grade 5 Hypoalbuminemia NCIDeath Grade 5 HypoalbuminemiaPTCTCAE E12315 Grade 5 Hypoalbuminemia Grade 5 Hypocalcemia NCIDeath Grade 5 HypocalcemiaPTCTCAE E12321 Grade 5 Hypocalcemia Grade 5 Hypoglycemia NCIDeath Grade 5 HypoglycemiaPTCTCAE E12326 Grade 5 Hypoglycemia Grade 5 Hypohidrosis NCIDeath Grade 5 HypohidrosisPTCTCAE E13656 Grade 5 Hypohidrosis Grade 5 Hypokalemia NCIDeath Grade 5 HypokalemiaPTCTCAE E12332 Grade 5 Hypokalemia Grade 5 Hypomagnesemia NCIDeath Grade 5 HypomagnesemiaPTCTCAE E12338 Grade 5 Hypomagnesemia Grade 5 Hyponatremia NCIDeath Grade 5 HyponatremiaPTCTCAE E12343 Grade 5 Hyponatremia Grade 5 Hypoparathyroidism NCIDeath Grade 5 HypoparathyroidismPTCTCAE E10333 Grade 5 Hypoparathyroidism Grade 5 Hypophosphatemia NCIDeath Grade 5 HypophosphatemiaPTCTCAE E12349 Grade 5 Hypophosphatemia Grade 5 Hypotension NCIDeath Grade 5 HypotensionPTCTCAE E13796 Grade 5 Hypotension Grade 5 Hypothermia NCIDeath Grade 5 HypothermiaPTCTCAE E11126 Grade 5 Hypothermia Grade 5 Hypothyroidism NCIDeath Grade 5 HypothyroidismPTCTCAE E10339 Grade 5 Hypothyroidism Grade 5 Hypoxia NCIDeath Grade 5 HypoxiaPTCTCAE E13392 Grade 5 Hypoxia Grade 5 Ileal fistula NCIDeath Grade 5 Ileal fistulaPTCTCAE E10782 Grade 5 Ileal fistula Grade 5 Ileal hemorrhage NCIDeath Grade 5 Ileal hemorrhagePTCTCAE E10788 Grade 5 Ileal hemorrhage Grade 5 Ileal obstruction NCIDeath Grade 5 Ileal obstructionPTCTCAE E10794 Grade 5 Ileal obstruction Grade 5 Ileal perforation NCIDeath Grade 5 Ileal perforationPTCTCAE E10799 Grade 5 Ileal perforation Grade 5 Ileal stenosis NCIDeath Grade 5 Ileal stenosisPTCTCAE E10805 Grade 5 Ileal stenosis Grade 5 Ileal ulcer NCIDeath Grade 5 Ileal ulcerPTCTCAE E10811 Grade 5 Ileal ulcer Grade 5 Ileus NCIDeath Grade 5 IleusPTCTCAE E10816 Grade 5 Ileus Grade 5 Immune system disorders - Other, specify NCIDeath Grade 5 Immune system disorders - Other, specifyPTCTCAE E11275 Grade 5 Immune system disorders - Other, specify Grade 5 Infections and infestations - Other, specify NCIDeath Grade 5 Infections and infestations - Other, specifyPTCTCAE E11420 Grade 5 Infections and infestations - Other, specify Grade 5 Infective myositis NCIDeath Grade 5 Infective myositisPTCTCAE E11425 Grade 5 Infective myositis Grade 5 Infusion related reaction NCIDeath Grade 5 Infusion related reactionPTCTCAE E11132 Grade 5 Infusion related reaction Grade 5 Infusion site extravasation NCIDeath Grade 5 Infusion site extravasationPTCTCAE E11137 Grade 5 Infusion site extravasation Grade 5 Injection site reaction NCIDeath Grade 5 Injection site reactionPTCTCAE E11143 Grade 5 Injection site reaction Grade 5 Injury, poisoning and procedural complications - Other, specify NCIDeath Grade 5 Injury, poisoning and procedural complications - Other, specifyPTCTCAE E11752 Grade 5 Injury, poisoning and procedural complications - Other, specify Grade 5 Injury to carotid artery NCIDeath Grade 5 Injury to carotid arteryPTCTCAE E11733 Grade 5 Injury to carotid artery Grade 5 Injury to inferior vena cava NCIDeath Grade 5 Injury to inferior vena cavaPTCTCAE E11736 Grade 5 Injury to inferior vena cava Grade 5 Injury to jugular vein NCIDeath Grade 5 Injury to jugular veinPTCTCAE E11740 Grade 5 Injury to jugular vein Grade 5 Injury to superior vena cava NCIDeath Grade 5 Injury to superior vena cavaPTCTCAE E11746 Grade 5 Injury to superior vena cava Grade 5 Intestinal stoma leak NCIDeath Grade 5 Intestinal stoma leakPTCTCAE E11758 Grade 5 Intestinal stoma leak Grade 5 Intestinal stoma obstruction NCIDeath Grade 5 Intestinal stoma obstructionPTCTCAE E11763 Grade 5 Intestinal stoma obstruction Grade 5 Intestinal stoma site bleeding NCIDeath Grade 5 Intestinal stoma site bleedingPTCTCAE E11769 Grade 5 Intestinal stoma site bleeding Grade 5 Intra-abdominal hemorrhage NCIDeath Grade 5 Intra-abdominal hemorrhagePTCTCAE E10821 Grade 5 Intra-abdominal hemorrhage Grade 5 Intracranial hemorrhage NCIDeath Grade 5 Intracranial hemorrhagePTCTCAE E12701 Grade 5 Intracranial hemorrhage Grade 5 Intraoperative arterial injury NCIDeath Grade 5 Intraoperative arterial injuryPTCTCAE E11775 Grade 5 Intraoperative arterial injury Grade 5 Intraoperative breast injury NCIDeath Grade 5 Intraoperative breast injuryPTCTCAE E11781 Grade 5 Intraoperative breast injury Grade 5 Intraoperative cardiac injury NCIDeath Grade 5 Intraoperative cardiac injuryPTCTCAE E11785 Grade 5 Intraoperative cardiac injury Grade 5 Intraoperative ear injury NCIDeath Grade 5 Intraoperative ear injuryPTCTCAE E11791 Grade 5 Intraoperative ear injury Grade 5 Intraoperative endocrine injury NCIDeath Grade 5 Intraoperative endocrine injuryPTCTCAE E11797 Grade 5 Intraoperative endocrine injury Grade 5 Intraoperative gastrointestinal injury NCIDeath Grade 5 Intraoperative gastrointestinal injuryPTCTCAE E11803 Grade 5 Intraoperative gastrointestinal injury Grade 5 Intraoperative head and neck injury NCIDeath Grade 5 Intraoperative head and neck injuryPTCTCAE E11809 Grade 5 Intraoperative head and neck injury Grade 5 Intraoperative hemorrhage NCIDeath Grade 5 Intraoperative hemorrhagePTCTCAE E11813 Grade 5 Intraoperative hemorrhage Grade 5 Intraoperative hepatobiliary injury NCIDeath Grade 5 Intraoperative hepatobiliary injuryPTCTCAE E11819 Grade 5 Intraoperative hepatobiliary injury Grade 5 Intraoperative musculoskeletal injury NCIDeath Grade 5 Intraoperative musculoskeletal injuryPTCTCAE E11825 Grade 5 Intraoperative musculoskeletal injury Grade 5 Intraoperative neurological injury NCIDeath Grade 5 Intraoperative neurological injuryPTCTCAE E11831 Grade 5 Intraoperative neurological injury Grade 5 Intraoperative ocular injury NCIDeath Grade 5 Intraoperative ocular injuryPTCTCAE E11837 Grade 5 Intraoperative ocular injury Grade 5 Intraoperative renal injury NCIDeath Grade 5 Intraoperative renal injuryPTCTCAE E11843 Grade 5 Intraoperative renal injury Grade 5 Intraoperative reproductive tract injury NCIDeath Grade 5 Intraoperative reproductive tract injuryPTCTCAE E11849 Grade 5 Intraoperative reproductive tract injury Grade 5 Intraoperative respiratory injury NCIDeath Grade 5 Intraoperative respiratory injuryPTCTCAE E11855 Grade 5 Intraoperative respiratory injury Grade 5 Intraoperative skin injury NCIDeath Grade 5 Intraoperative skin injuryPTCTCAE E11861 Grade 5 Intraoperative skin injury Grade 5 Intraoperative splenic injury NCIDeath Grade 5 Intraoperative splenic injuryPTCTCAE E11866 Grade 5 Intraoperative splenic injury Grade 5 Intraoperative urinary injury NCIDeath Grade 5 Intraoperative urinary injuryPTCTCAE E11872 Grade 5 Intraoperative urinary injury Grade 5 Intraoperative venous injury NCIDeath Grade 5 Intraoperative venous injuryPTCTCAE E11878 Grade 5 Intraoperative venous injury Grade 5 Investigations - Other, specify NCIDeath Grade 5 Investigations - Other, specifyPTCTCAE E12184 Grade 5 Investigations - Other, specify Grade 5 Iron overload NCIDeath Grade 5 Iron overloadPTCTCAE E12354 Grade 5 Iron overload Grade 5 Jejunal fistula NCIDeath Grade 5 Jejunal fistulaPTCTCAE E10827 Grade 5 Jejunal fistula Grade 5 Jejunal hemorrhage NCIDeath Grade 5 Jejunal hemorrhagePTCTCAE E10833 Grade 5 Jejunal hemorrhage Grade 5 Jejunal obstruction NCIDeath Grade 5 Jejunal obstructionPTCTCAE E10839 Grade 5 Jejunal obstruction Grade 5 Jejunal perforation NCIDeath Grade 5 Jejunal perforationPTCTCAE E10844 Grade 5 Jejunal perforation Grade 5 Jejunal stenosis NCIDeath Grade 5 Jejunal stenosisPTCTCAE E10850 Grade 5 Jejunal stenosis Grade 5 Jejunal ulcer NCIDeath Grade 5 Jejunal ulcerPTCTCAE E10856 Grade 5 Jejunal ulcer Grade 5 Joint infection NCIDeath Grade 5 Joint infectionPTCTCAE E11430 Grade 5 Joint infection Grade 5 Kidney anastomotic leak NCIDeath Grade 5 Kidney anastomotic leakPTCTCAE E11884 Grade 5 Kidney anastomotic leak Grade 5 Kidney infection NCIDeath Grade 5 Kidney infectionPTCTCAE E11434 Grade 5 Kidney infection Grade 5 Large intestinal anastomotic leak NCIDeath Grade 5 Large intestinal anastomotic leakPTCTCAE E11890 Grade 5 Large intestinal anastomotic leak Grade 5 Laryngeal edema NCIDeath Grade 5 Laryngeal edemaPTCTCAE E13398 Grade 5 Laryngeal edema Grade 5 Laryngeal fistula NCIDeath Grade 5 Laryngeal fistulaPTCTCAE E13404 Grade 5 Laryngeal fistula Grade 5 Laryngeal hemorrhage NCIDeath Grade 5 Laryngeal hemorrhagePTCTCAE E13410 Grade 5 Laryngeal hemorrhage Grade 5 Laryngeal mucositis NCIDeath Grade 5 Laryngeal mucositisPTCTCAE E13420 Grade 5 Laryngeal mucositis Grade 5 Laryngeal obstruction NCIDeath Grade 5 Laryngeal obstructionPTCTCAE E13426 Grade 5 Laryngeal obstruction Grade 5 Laryngeal stenosis NCIDeath Grade 5 Laryngeal stenosisPTCTCAE E13432 Grade 5 Laryngeal stenosis Grade 5 Laryngitis NCIDeath Grade 5 LaryngitisPTCTCAE E11439 Grade 5 Laryngitis Grade 5 Laryngopharyngeal dysesthesia NCIDeath Grade 5 Laryngopharyngeal dysesthesiaPTCTCAE E13438 Grade 5 Laryngopharyngeal dysesthesia Grade 5 Laryngospasm NCIDeath Grade 5 LaryngospasmPTCTCAE E13443 Grade 5 Laryngospasm Grade 5 Left ventricular systolic dysfunction NCIDeath Grade 5 Left ventricular systolic dysfunctionPTCTCAE E10133 Grade 5 Left ventricular systolic dysfunction Grade 5 Leukemia secondary to oncology chemotherapy NCIDeath Grade 5 Leukemia secondary to oncology chemotherapyPTCTCAE E12551 Grade 5 Leukemia secondary to oncology chemotherapy Grade 5 Leukocytosis NCIDeath Grade 5 LeukocytosisPTCTCAE E10051 Grade 5 Leukocytosis Grade 5 Leukoencephalopathy NCIDeath Grade 5 LeukoencephalopathyPTCTCAE E12717 Grade 5 Leukoencephalopathy Grade 5 Lower gastrointestinal hemorrhage NCIDeath Grade 5 Lower gastrointestinal hemorrhagePTCTCAE E10866 Grade 5 Lower gastrointestinal hemorrhage Grade 5 Lung infection NCIDeath Grade 5 Lung infectionPTCTCAE E11448 Grade 5 Lung infection Grade 5 Lymph gland infection NCIDeath Grade 5 Lymph gland infectionPTCTCAE E11453 Grade 5 Lymph gland infection Grade 5 Lymph leakage NCIDeath Grade 5 Lymph leakagePTCTCAE E13801 Grade 5 Lymph leakage Grade 5 Malabsorption NCIDeath Grade 5 MalabsorptionPTCTCAE E10871 Grade 5 Malabsorption Grade 5 Mania NCIDeath Grade 5 ManiaPTCTCAE E12941 Grade 5 Mania Grade 5 Mediastinal hemorrhage NCIDeath Grade 5 Mediastinal hemorrhagePTCTCAE E13449 Grade 5 Mediastinal hemorrhage Grade 5 Mediastinal infection NCIDeath Grade 5 Mediastinal infectionPTCTCAE E11457 Grade 5 Mediastinal infection Grade 5 Meningismus NCIDeath Grade 5 MeningismusPTCTCAE E12727 Grade 5 Meningismus Grade 5 Meningitis NCIDeath Grade 5 MeningitisPTCTCAE E11461 Grade 5 Meningitis Grade 5 Menorrhagia NCIDeath Grade 5 MenorrhagiaPTCTCAE E13137 Grade 5 Menorrhagia Grade 5 Metabolism and nutrition disorders - Other, specify NCIDeath Grade 5 Metabolism and nutrition disorders - Other, specifyPTCTCAE E12360 Grade 5 Metabolism and nutrition disorders - Other, specify Grade 5 Middle ear inflammation NCIDeath Grade 5 Middle ear inflammationPTCTCAE E10286 Grade 5 Middle ear inflammation Grade 5 Mitral valve disease NCIDeath Grade 5 Mitral valve diseasePTCTCAE E10139 Grade 5 Mitral valve disease Grade 5 Mobitz type I NCIDeath Grade 5 Mobitz type IPTCTCAE E10151 Grade 5 Mobitz type I Grade 5 Mobitz (type) II atrioventricular block NCIDeath Grade 5 Mobitz (type) II atrioventricular blockPTCTCAE E10145 Grade 5 Mobitz (type) II atrioventricular block Grade 5 Mucosal infection NCIDeath Grade 5 Mucosal infectionPTCTCAE E11467 Grade 5 Mucosal infection Grade 5 Mucositis oral NCIDeath Grade 5 Mucositis oralPTCTCAE E10877 Grade 5 Mucositis oral Grade 5 Multi-organ failure NCIDeath Grade 5 Multi-organ failurePTCTCAE E11158 Grade 5 Multi-organ failure Grade 5 Musculoskeletal and connective tissue disorder - Other, specify NCIDeath Grade 5 Musculoskeletal and connective tissue disorder - Other, specifyPTCTCAE E12480 Grade 5 Musculoskeletal and connective tissue disorder - Other, specify Grade 5 Myelitis NCIDeath Grade 5 MyelitisPTCTCAE E12737 Grade 5 Myelitis Grade 5 Myelodysplastic syndrome NCIDeath Grade 5 Myelodysplastic syndromePTCTCAE E12554 Grade 5 Myelodysplastic syndrome Grade 5 Myocardial infarction NCIDeath Grade 5 Myocardial infarctionPTCTCAE E10156 Grade 5 Myocardial infarction Grade 5 Myocarditis NCIDeath Grade 5 MyocarditisPTCTCAE E10162 Grade 5 Myocarditis Grade 5 Neck soft tissue necrosis NCIDeath Grade 5 Neck soft tissue necrosisPTCTCAE E12501 Grade 5 Neck soft tissue necrosis Grade 5 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify NCIDeath Grade 5 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specifyPTCTCAE E12560 Grade 5 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify Grade 5 Nervous system disorders - Other, specify NCIDeath Grade 5 Nervous system disorders - Other, specifyPTCTCAE E12743 Grade 5 Nervous system disorders - Other, specify Grade 5 Obstruction gastric NCIDeath Grade 5 Obstruction gastricPTCTCAE E10887 Grade 5 Obstruction gastric Grade 5 Oral cavity fistula NCIDeath Grade 5 Oral cavity fistulaPTCTCAE E10893 Grade 5 Oral cavity fistula Grade 5 Oral hemorrhage NCIDeath Grade 5 Oral hemorrhagePTCTCAE E10903 Grade 5 Oral hemorrhage Grade 5 Osteonecrosis of jaw NCIDeath Grade 5 Osteonecrosis of jawPTCTCAE E12507 Grade 5 Osteonecrosis of jaw Grade 5 Otitis externa NCIDeath Grade 5 Otitis externaPTCTCAE E11476 Grade 5 Otitis externa Grade 5 Otitis media NCIDeath Grade 5 Otitis mediaPTCTCAE E11481 Grade 5 Otitis media Grade 5 Ovarian hemorrhage NCIDeath Grade 5 Ovarian hemorrhagePTCTCAE E13150 Grade 5 Ovarian hemorrhage Grade 5 Ovarian infection NCIDeath Grade 5 Ovarian infectionPTCTCAE E11486 Grade 5 Ovarian infection Grade 5 Ovarian rupture NCIDeath Grade 5 Ovarian rupturePTCTCAE E13156 Grade 5 Ovarian rupture Grade 5 Pancreas infection NCIDeath Grade 5 Pancreas infectionPTCTCAE E11490 Grade 5 Pancreas infection Grade 5 Pancreatic anastomotic leak NCIDeath Grade 5 Pancreatic anastomotic leakPTCTCAE E11896 Grade 5 Pancreatic anastomotic leak Grade 5 Pancreatic duct stenosis NCIDeath Grade 5 Pancreatic duct stenosisPTCTCAE E10913 Grade 5 Pancreatic duct stenosis Grade 5 Pancreatic fistula NCIDeath Grade 5 Pancreatic fistulaPTCTCAE E10919 Grade 5 Pancreatic fistula Grade 5 Pancreatic hemorrhage NCIDeath Grade 5 Pancreatic hemorrhagePTCTCAE E10925 Grade 5 Pancreatic hemorrhage Grade 5 Pancreatic necrosis NCIDeath Grade 5 Pancreatic necrosisPTCTCAE E10929 Grade 5 Pancreatic necrosis Grade 5 Pancreatitis NCIDeath Grade 5 PancreatitisPTCTCAE E10934 Grade 5 Pancreatitis Grade 5 Papulopustular rash NCIDeath Grade 5 Papulopustular rashPTCTCAE E11496 Grade 5 Papulopustular rash Grade 5 Paroxysmal atrial tachycardia NCIDeath Grade 5 Paroxysmal atrial tachycardiaPTCTCAE E10171 Grade 5 Paroxysmal atrial tachycardia Grade 5 Pelvic floor muscle weakness NCIDeath Grade 5 Pelvic floor muscle weaknessPTCTCAE E13166 Grade 5 Pelvic floor muscle weakness Grade 5 Pelvic infection NCIDeath Grade 5 Pelvic infectionPTCTCAE E11505 Grade 5 Pelvic infection Grade 5 Pelvic soft tissue necrosis NCIDeath Grade 5 Pelvic soft tissue necrosisPTCTCAE E12520 Grade 5 Pelvic soft tissue necrosis Grade 5 Penile infection NCIDeath Grade 5 Penile infectionPTCTCAE E11510 Grade 5 Penile infection Grade 5 Perforation bile duct NCIDeath Grade 5 Perforation bile ductPTCTCAE E11237 Grade 5 Perforation bile duct Grade 5 Pericardial effusion NCIDeath Grade 5 Pericardial effusionPTCTCAE E10176 Grade 5 Pericardial effusion Grade 5 Pericardial tamponade NCIDeath Grade 5 Pericardial tamponadePTCTCAE E10179 Grade 5 Pericardial tamponade Grade 5 Pericarditis NCIDeath Grade 5 PericarditisPTCTCAE E10185 Grade 5 Pericarditis Grade 5 Periorbital infection NCIDeath Grade 5 Periorbital infectionPTCTCAE E11515 Grade 5 Periorbital infection Grade 5 Peripheral ischemia NCIDeath Grade 5 Peripheral ischemiaPTCTCAE E13814 Grade 5 Peripheral ischemia Grade 5 Peripheral motor neuropathy NCIDeath Grade 5 Peripheral motor neuropathyPTCTCAE E12767 Grade 5 Peripheral motor neuropathy Grade 5 Peripheral nerve infection NCIDeath Grade 5 Peripheral nerve infectionPTCTCAE E11520 Grade 5 Peripheral nerve infection Grade 5 Peripheral sensory neuropathy NCIDeath Grade 5 Peripheral sensory neuropathyPTCTCAE E12773 Grade 5 Peripheral sensory neuropathy Grade 5 Peritoneal infection NCIDeath Grade 5 Peritoneal infectionPTCTCAE E11524 Grade 5 Peritoneal infection Grade 5 Peritoneal necrosis NCIDeath Grade 5 Peritoneal necrosisPTCTCAE E10942 Grade 5 Peritoneal necrosis Grade 5 Personality change NCIDeath Grade 5 Personality changePTCTCAE E12947 Grade 5 Personality change Grade 5 Pharyngeal anastomotic leak NCIDeath Grade 5 Pharyngeal anastomotic leakPTCTCAE E11902 Grade 5 Pharyngeal anastomotic leak Grade 5 Pharyngeal fistula NCIDeath Grade 5 Pharyngeal fistulaPTCTCAE E13459 Grade 5 Pharyngeal fistula Grade 5 Pharyngeal hemorrhage NCIDeath Grade 5 Pharyngeal hemorrhagePTCTCAE E13465 Grade 5 Pharyngeal hemorrhage Grade 5 Pharyngeal mucositis NCIDeath Grade 5 Pharyngeal mucositisPTCTCAE E13471 Grade 5 Pharyngeal mucositis Grade 5 Pharyngeal necrosis NCIDeath Grade 5 Pharyngeal necrosisPTCTCAE E13475 Grade 5 Pharyngeal necrosis Grade 5 Pharyngeal stenosis NCIDeath Grade 5 Pharyngeal stenosisPTCTCAE E13481 Grade 5 Pharyngeal stenosis Grade 5 Pharyngitis NCIDeath Grade 5 PharyngitisPTCTCAE E11529 Grade 5 Pharyngitis Grade 5 Phlebitis infective NCIDeath Grade 5 Phlebitis infectivePTCTCAE E11534 Grade 5 Phlebitis infective Grade 5 Photosensitivity NCIDeath Grade 5 PhotosensitivityPTCTCAE E13685 Grade 5 Photosensitivity Grade 5 Pleural effusion NCIDeath Grade 5 Pleural effusionPTCTCAE E13491 Grade 5 Pleural effusion Grade 5 Pleural hemorrhage NCIDeath Grade 5 Pleural hemorrhagePTCTCAE E13497 Grade 5 Pleural hemorrhage Grade 5 Pleural infection NCIDeath Grade 5 Pleural infectionPTCTCAE E11539 Grade 5 Pleural infection Grade 5 Pneumonitis NCIDeath Grade 5 PneumonitisPTCTCAE E13507 Grade 5 Pneumonitis Grade 5 Pneumothorax NCIDeath Grade 5 PneumothoraxPTCTCAE E13513 Grade 5 Pneumothorax Grade 5 Portal hypertension NCIDeath Grade 5 Portal hypertensionPTCTCAE E11242 Grade 5 Portal hypertension Grade 5 Portal vein thrombosis NCIDeath Grade 5 Portal vein thrombosisPTCTCAE E11247 Grade 5 Portal vein thrombosis Grade 5 Postoperative hemorrhage NCIDeath Grade 5 Postoperative hemorrhagePTCTCAE E11908 Grade 5 Postoperative hemorrhage Grade 5 Postoperative thoracic procedure complication NCIDeath Grade 5 Postoperative thoracic procedure complicationPTCTCAE E11913 Grade 5 Postoperative thoracic procedure complication Grade 5 Pregnancy, puerperium and perinatal conditions - Other, specify NCIDeath Grade 5 Pregnancy, puerperium and perinatal conditions - Other, specifyPTCTCAE E12866 Grade 5 Pregnancy, puerperium and perinatal conditions - Other, specify Grade 5 Proctitis NCIDeath Grade 5 ProctitisPTCTCAE E10948 Grade 5 Proctitis Grade 5 Prolapse of intestinal stoma NCIDeath Grade 5 Prolapse of intestinal stomaPTCTCAE E11919 Grade 5 Prolapse of intestinal stoma Grade 5 Prolapse of urostomy NCIDeath Grade 5 Prolapse of urostomyPTCTCAE E11925 Grade 5 Prolapse of urostomy Grade 5 Prostate infection NCIDeath Grade 5 Prostate infectionPTCTCAE E11544 Grade 5 Prostate infection Grade 5 Prostatic hemorrhage NCIDeath Grade 5 Prostatic hemorrhagePTCTCAE E13186 Grade 5 Prostatic hemorrhage Grade 5 Psychiatric disorders - Other, specify NCIDeath Grade 5 Psychiatric disorders - Other, specifyPTCTCAE E12953 Grade 5 Psychiatric disorders - Other, specify Grade 5 Psychosis NCIDeath Grade 5 PsychosisPTCTCAE E12959 Grade 5 Psychosis Grade 5 Pulmonary edema NCIDeath Grade 5 Pulmonary edemaPTCTCAE E13526 Grade 5 Pulmonary edema Grade 5 Pulmonary fibrosis NCIDeath Grade 5 Pulmonary fibrosisPTCTCAE E13532 Grade 5 Pulmonary fibrosis Grade 5 Pulmonary fistula NCIDeath Grade 5 Pulmonary fistulaPTCTCAE E13538 Grade 5 Pulmonary fistula Grade 5 Pulmonary hypertension NCIDeath Grade 5 Pulmonary hypertensionPTCTCAE E13544 Grade 5 Pulmonary hypertension Grade 5 Pulmonary valve disease NCIDeath Grade 5 Pulmonary valve diseasePTCTCAE E10191 Grade 5 Pulmonary valve disease Grade 5 Pyramidal tract syndrome NCIDeath Grade 5 Pyramidal tract syndromePTCTCAE E12785 Grade 5 Pyramidal tract syndrome Grade 5 Radiation recall reaction (dermatologic) NCIDeath Grade 5 Radiation recall reaction (dermatologic)PTCTCAE E11931 Grade 5 Radiation recall reaction (dermatologic) Grade 5 Radiculitis NCIDeath Grade 5 RadiculitisPTCTCAE E12791 Grade 5 Radiculitis Grade 5 Rash acneiform NCIDeath Grade 5 Rash acneiformPTCTCAE E13699 Grade 5 Rash acneiform Grade 5 Rectal anastomotic leak NCIDeath Grade 5 Rectal anastomotic leakPTCTCAE E11937 Grade 5 Rectal anastomotic leak Grade 5 Rectal fistula NCIDeath Grade 5 Rectal fistulaPTCTCAE E10954 Grade 5 Rectal fistula Grade 5 Rectal hemorrhage NCIDeath Grade 5 Rectal hemorrhagePTCTCAE E10960 Grade 5 Rectal hemorrhage Grade 5 Rectal mucositis NCIDeath Grade 5 Rectal mucositisPTCTCAE E10966 Grade 5 Rectal mucositis Grade 5 Rectal necrosis NCIDeath Grade 5 Rectal necrosisPTCTCAE E10970 Grade 5 Rectal necrosis Grade 5 Rectal obstruction NCIDeath Grade 5 Rectal obstructionPTCTCAE E10976 Grade 5 Rectal obstruction Grade 5 Rectal perforation NCIDeath Grade 5 Rectal perforationPTCTCAE E10985 Grade 5 Rectal perforation Grade 5 Rectal stenosis NCIDeath Grade 5 Rectal stenosisPTCTCAE E10991 Grade 5 Rectal stenosis Grade 5 Rectal ulcer NCIDeath Grade 5 Rectal ulcerPTCTCAE E10997 Grade 5 Rectal ulcer Grade 5 Recurrent laryngeal nerve palsy NCIDeath Grade 5 Recurrent laryngeal nerve palsyPTCTCAE E12797 Grade 5 Recurrent laryngeal nerve palsy Grade 5 Renal and urinary disorders - Other, specify NCIDeath Grade 5 Renal and urinary disorders - Other, specifyPTCTCAE E13017 Grade 5 Renal and urinary disorders - Other, specify Grade 5 Renal calculi NCIDeath Grade 5 Renal calculiPTCTCAE E13023 Grade 5 Renal calculi Grade 5 Renal hemorrhage NCIDeath Grade 5 Renal hemorrhagePTCTCAE E13033 Grade 5 Renal hemorrhage Grade 5 Reproductive system and breast disorders - Other, specify NCIDeath Grade 5 Reproductive system and breast disorders - Other, specifyPTCTCAE E13200 Grade 5 Reproductive system and breast disorders - Other, specify Grade 5 Respiratory failure NCIDeath Grade 5 Respiratory failurePTCTCAE E13547 Grade 5 Respiratory failure Grade 5 Respiratory, thoracic and mediastinal disorders - Other, specify NCIDeath Grade 5 Respiratory, thoracic and mediastinal disorders - Other, specifyPTCTCAE E13553 Grade 5 Respiratory, thoracic and mediastinal disorders - Other, specify Grade 5 Restrictive cardiomyopathy NCIDeath Grade 5 Restrictive cardiomyopathyPTCTCAE E10195 Grade 5 Restrictive cardiomyopathy Grade 5 Retinoic acid syndrome NCIDeath Grade 5 Retinoic acid syndromePTCTCAE E13559 Grade 5 Retinoic acid syndrome Grade 5 Retroperitoneal hemorrhage NCIDeath Grade 5 Retroperitoneal hemorrhagePTCTCAE E11002 Grade 5 Retroperitoneal hemorrhage Grade 5 Reversible posterior leukoencephalopathy syndrome NCIDeath Grade 5 Reversible posterior leukoencephalopathy syndromePTCTCAE E12803 Grade 5 Reversible posterior leukoencephalopathy syndrome Grade 5 Right ventricular dysfunction NCIDeath Grade 5 Right ventricular dysfunctionPTCTCAE E10201 Grade 5 Right ventricular dysfunction Grade 5 Salivary duct inflammation NCIDeath Grade 5 Salivary duct inflammationPTCTCAE E11008 Grade 5 Salivary duct inflammation Grade 5 Salivary gland fistula NCIDeath Grade 5 Salivary gland fistulaPTCTCAE E11014 Grade 5 Salivary gland fistula Grade 5 Salivary gland infection NCIDeath Grade 5 Salivary gland infectionPTCTCAE E11554 Grade 5 Salivary gland infection Grade 5 Scrotal infection NCIDeath Grade 5 Scrotal infectionPTCTCAE E11559 Grade 5 Scrotal infection Grade 5 Seizure NCIDeath Grade 5 SeizurePTCTCAE E12809 Grade 5 Seizure Grade 5 Sepsis NCIDeath Grade 5 SepsisPTCTCAE E11562 Grade 5 Sepsis Grade 5 Serum sickness NCIDeath Grade 5 Serum sicknessPTCTCAE E11281 Grade 5 Serum sickness Grade 5 Sick sinus syndrome NCIDeath Grade 5 Sick sinus syndromePTCTCAE E10207 Grade 5 Sick sinus syndrome Grade 5 Sinus bradycardia NCIDeath Grade 5 Sinus bradycardiaPTCTCAE E10213 Grade 5 Sinus bradycardia Grade 5 Sinus disorder NCIDeath Grade 5 Sinus disorderPTCTCAE E13565 Grade 5 Sinus disorder Grade 5 Sinusitis NCIDeath Grade 5 SinusitisPTCTCAE E11567 Grade 5 Sinusitis Grade 5 Skin and subcutaneous tissue disorders - Other, specify NCIDeath Grade 5 Skin and subcutaneous tissue disorders - Other, specifyPTCTCAE E13713 Grade 5 Skin and subcutaneous tissue disorders - Other, specify Grade 5 Skin induration NCIDeath Grade 5 Skin indurationPTCTCAE E13729 Grade 5 Skin induration Grade 5 Skin infection NCIDeath Grade 5 Skin infectionPTCTCAE E11573 Grade 5 Skin infection Grade 5 Skin ulceration NCIDeath Grade 5 Skin ulcerationPTCTCAE E13735 Grade 5 Skin ulceration Grade 5 Sleep apnea NCIDeath Grade 5 Sleep apneaPTCTCAE E13571 Grade 5 Sleep apnea Grade 5 Small intestinal anastomotic leak NCIDeath Grade 5 Small intestinal anastomotic leakPTCTCAE E11947 Grade 5 Small intestinal anastomotic leak Grade 5 Small intestinal mucositis NCIDeath Grade 5 Small intestinal mucositisPTCTCAE E11020 Grade 5 Small intestinal mucositis Grade 5 Small intestinal obstruction NCIDeath Grade 5 Small intestinal obstructionPTCTCAE E11026 Grade 5 Small intestinal obstruction Grade 5 Small intestinal perforation NCIDeath Grade 5 Small intestinal perforationPTCTCAE E11031 Grade 5 Small intestinal perforation Grade 5 Small intestinal stenosis NCIDeath Grade 5 Small intestinal stenosisPTCTCAE E11037 Grade 5 Small intestinal stenosis Grade 5 Small intestine infection NCIDeath Grade 5 Small intestine infectionPTCTCAE E11578 Grade 5 Small intestine infection Grade 5 Small intestine ulcer NCIDeath Grade 5 Small intestine ulcerPTCTCAE E11043 Grade 5 Small intestine ulcer Grade 5 Social circumstances - Other, specify NCIDeath Grade 5 Social circumstances - Other, specifyPTCTCAE E13759 Grade 5 Social circumstances - Other, specify Grade 5 Soft tissue infection NCIDeath Grade 5 Soft tissue infectionPTCTCAE E11583 Grade 5 Soft tissue infection Grade 5 Soft tissue necrosis lower limb NCIDeath Grade 5 Soft tissue necrosis lower limbPTCTCAE E12529 Grade 5 Soft tissue necrosis lower limb Grade 5 Soft tissue necrosis upper limb NCIDeath Grade 5 Soft tissue necrosis upper limbPTCTCAE E12534 Grade 5 Soft tissue necrosis upper limb Grade 5 Somnolence NCIDeath Grade 5 SomnolencePTCTCAE E12819 Grade 5 Somnolence Grade 5 Spasticity NCIDeath Grade 5 SpasticityPTCTCAE E12825 Grade 5 Spasticity Grade 5 Spermatic cord anastomotic leak NCIDeath Grade 5 Spermatic cord anastomotic leakPTCTCAE E11953 Grade 5 Spermatic cord anastomotic leak Grade 5 Spermatic cord hemorrhage NCIDeath Grade 5 Spermatic cord hemorrhagePTCTCAE E13210 Grade 5 Spermatic cord hemorrhage Grade 5 Spinal fracture NCIDeath Grade 5 Spinal fracturePTCTCAE E11959 Grade 5 Spinal fracture Grade 5 Spleen disorder NCIDeath Grade 5 Spleen disorderPTCTCAE E10060 Grade 5 Spleen disorder Grade 5 Splenic infection NCIDeath Grade 5 Splenic infectionPTCTCAE E11587 Grade 5 Splenic infection Grade 5 Stenosis of gastrointestinal stoma NCIDeath Grade 5 Stenosis of gastrointestinal stomaPTCTCAE E11964 Grade 5 Stenosis of gastrointestinal stoma Grade 5 Stevens-Johnson syndrome NCIDeath Grade 5 Stevens-Johnson syndromePTCTCAE E13739 Grade 5 Stevens-Johnson syndrome Grade 5 Stoma site infection NCIDeath Grade 5 Stoma site infectionPTCTCAE E11593 Grade 5 Stoma site infection Grade 5 Stridor NCIDeath Grade 5 StridorPTCTCAE E13582 Grade 5 Stridor Grade 5 Stroke NCIDeath Grade 5 StrokePTCTCAE E12831 Grade 5 Stroke Grade 5 Sudden death NOS NCIDeath Grade 5 Sudden death NOSPTCTCAE E11172 Grade 5 Sudden death NOS Grade 5 Suicide attempt NCIDeath Grade 5 Suicide attemptPTCTCAE E12972 Grade 5 Suicide attempt Grade 5 Superficial soft tissue fibrosis NCIDeath Grade 5 Superficial soft tissue fibrosisPTCTCAE E12540 Grade 5 Superficial soft tissue fibrosis Grade 5 Superior vena cava syndrome NCIDeath Grade 5 Superior vena cava syndromePTCTCAE E13824 Grade 5 Superior vena cava syndrome Grade 5 Supraventricular tachycardia NCIDeath Grade 5 Supraventricular tachycardiaPTCTCAE E10223 Grade 5 Supraventricular tachycardia Grade 5 Surgical and medical procedures - Other, specify NCIDeath Grade 5 Surgical and medical procedures - Other, specifyPTCTCAE E13765 Grade 5 Surgical and medical procedures - Other, specify Grade 5 Testicular disorder NCIDeath Grade 5 Testicular disorderPTCTCAE E13220 Grade 5 Testicular disorder Grade 5 Testicular hemorrhage NCIDeath Grade 5 Testicular hemorrhagePTCTCAE E13226 Grade 5 Testicular hemorrhage Grade 5 Thromboembolic event NCIDeath Grade 5 Thromboembolic eventPTCTCAE E13830 Grade 5 Thromboembolic event Grade 5 Thrombotic thrombocytopenic purpura NCIDeath Grade 5 Thrombotic thrombocytopenic purpuraPTCTCAE E10065 Grade 5 Thrombotic thrombocytopenic purpura Grade 5 Tooth infection NCIDeath Grade 5 Tooth infectionPTCTCAE E11598 Grade 5 Tooth infection Grade 5 Toxic epidermal necrolysis NCIDeath Grade 5 Toxic epidermal necrolysisPTCTCAE E13745 Grade 5 Toxic epidermal necrolysis Grade 5 Tracheal fistula NCIDeath Grade 5 Tracheal fistulaPTCTCAE E13588 Grade 5 Tracheal fistula Grade 5 Tracheal hemorrhage NCIDeath Grade 5 Tracheal hemorrhagePTCTCAE E11974 Grade 5 Tracheal hemorrhage Grade 5 Tracheal mucositis NCIDeath Grade 5 Tracheal mucositisPTCTCAE E13594 Grade 5 Tracheal mucositis Grade 5 Tracheal obstruction NCIDeath Grade 5 Tracheal obstructionPTCTCAE E11980 Grade 5 Tracheal obstruction Grade 5 Tracheal stenosis NCIDeath Grade 5 Tracheal stenosisPTCTCAE E13600 Grade 5 Tracheal stenosis Grade 5 Tracheitis NCIDeath Grade 5 TracheitisPTCTCAE E11603 Grade 5 Tracheitis Grade 5 Tracheostomy site bleeding NCIDeath Grade 5 Tracheostomy site bleedingPTCTCAE E11986 Grade 5 Tracheostomy site bleeding Grade 5 Treatment related secondary malignancy NCIDeath Grade 5 Treatment related secondary malignancyPTCTCAE E12564 Grade 5 Treatment related secondary malignancy Grade 5 Tricuspid valve disease NCIDeath Grade 5 Tricuspid valve diseasePTCTCAE E10229 Grade 5 Tricuspid valve disease Grade 5 Tumor lysis syndrome NCIDeath Grade 5 Tumor lysis syndromePTCTCAE E12368 Grade 5 Tumor lysis syndrome Grade 5 Typhlitis NCIDeath Grade 5 TyphlitisPTCTCAE E11061 Grade 5 Typhlitis Grade 5 Upper gastrointestinal hemorrhage NCIDeath Grade 5 Upper gastrointestinal hemorrhagePTCTCAE E11067 Grade 5 Upper gastrointestinal hemorrhage Grade 5 Upper respiratory infection NCIDeath Grade 5 Upper respiratory infectionPTCTCAE E11608 Grade 5 Upper respiratory infection Grade 5 Ureteric anastomotic leak NCIDeath Grade 5 Ureteric anastomotic leakPTCTCAE E11992 Grade 5 Ureteric anastomotic leak Grade 5 Urethral anastomotic leak NCIDeath Grade 5 Urethral anastomotic leakPTCTCAE E11998 Grade 5 Urethral anastomotic leak Grade 5 Urethral infection NCIDeath Grade 5 Urethral infectionPTCTCAE E11613 Grade 5 Urethral infection Grade 5 Urinary fistula NCIDeath Grade 5 Urinary fistulaPTCTCAE E13038 Grade 5 Urinary fistula Grade 5 Urinary retention NCIDeath Grade 5 Urinary retentionPTCTCAE E13051 Grade 5 Urinary retention Grade 5 Urinary tract infection NCIDeath Grade 5 Urinary tract infectionPTCTCAE E11618 Grade 5 Urinary tract infection Grade 5 Urinary tract obstruction NCIDeath Grade 5 Urinary tract obstructionPTCTCAE E13057 Grade 5 Urinary tract obstruction Grade 5 Urostomy leak NCIDeath Grade 5 Urostomy leakPTCTCAE E12004 Grade 5 Urostomy leak Grade 5 Urostomy obstruction NCIDeath Grade 5 Urostomy obstructionPTCTCAE E12010 Grade 5 Urostomy obstruction Grade 5 Urostomy site bleeding NCIDeath Grade 5 Urostomy site bleedingPTCTCAE E12016 Grade 5 Urostomy site bleeding Grade 5 Urostomy stenosis NCIDeath Grade 5 Urostomy stenosisPTCTCAE E12021 Grade 5 Urostomy stenosis Grade 5 Uterine anastomotic leak NCIDeath Grade 5 Uterine anastomotic leakPTCTCAE E12027 Grade 5 Uterine anastomotic leak Grade 5 Uterine fistula NCIDeath Grade 5 Uterine fistulaPTCTCAE E13236 Grade 5 Uterine fistula Grade 5 Uterine hemorrhage NCIDeath Grade 5 Uterine hemorrhagePTCTCAE E13242 Grade 5 Uterine hemorrhage Grade 5 Uterine infection NCIDeath Grade 5 Uterine infectionPTCTCAE E11623 Grade 5 Uterine infection Grade 5 Uterine perforation NCIDeath Grade 5 Uterine perforationPTCTCAE E12033 Grade 5 Uterine perforation Grade 5 Vaginal anastomotic leak NCIDeath Grade 5 Vaginal anastomotic leakPTCTCAE E12039 Grade 5 Vaginal anastomotic leak Grade 5 Vaginal fistula NCIDeath Grade 5 Vaginal fistulaPTCTCAE E13263 Grade 5 Vaginal fistula Grade 5 Vaginal hemorrhage NCIDeath Grade 5 Vaginal hemorrhagePTCTCAE E13269 Grade 5 Vaginal hemorrhage Grade 5 Vaginal infection NCIDeath Grade 5 Vaginal infectionPTCTCAE E11628 Grade 5 Vaginal infection Grade 5 Vaginal inflammation NCIDeath Grade 5 Vaginal inflammationPTCTCAE E13275 Grade 5 Vaginal inflammation Grade 5 Vaginal perforation NCIDeath Grade 5 Vaginal perforationPTCTCAE E13289 Grade 5 Vaginal perforation Grade 5 Vaginal stricture NCIDeath Grade 5 Vaginal stricturePTCTCAE E13294 Grade 5 Vaginal stricture Grade 5 Vagus nerve disorder NCIDeath Grade 5 Vagus nerve disorderPTCTCAE E12850 Grade 5 Vagus nerve disorder Grade 5 Vas deferens anastomotic leak NCIDeath Grade 5 Vas deferens anastomotic leakPTCTCAE E12045 Grade 5 Vas deferens anastomotic leak Grade 5 Vascular access complication NCIDeath Grade 5 Vascular access complicationPTCTCAE E12050 Grade 5 Vascular access complication Grade 5 Vascular disorders - Other, specify NCIDeath Grade 5 Vascular disorders - Other, specifyPTCTCAE E13836 Grade 5 Vascular disorders - Other, specify Grade 5 Vasculitis NCIDeath Grade 5 VasculitisPTCTCAE E13842 Grade 5 Vasculitis Grade 5 Vasovagal reaction NCIDeath Grade 5 Vasovagal reactionPTCTCAE E12854 Grade 5 Vasovagal reaction Grade 5 Venous injury NCIDeath Grade 5 Venous injuryPTCTCAE E12056 Grade 5 Venous injury Grade 5 Ventricular arrhythmia NCIDeath Grade 5 Ventricular arrhythmiaPTCTCAE E10235 Grade 5 Ventricular arrhythmia Grade 5 Ventricular fibrillation NCIDeath Grade 5 Ventricular fibrillationPTCTCAE E10238 Grade 5 Ventricular fibrillation Grade 5 Ventricular tachycardia NCIDeath Grade 5 Ventricular tachycardiaPTCTCAE E10243 Grade 5 Ventricular tachycardia Grade 5 Visceral arterial ischemia NCIDeath Grade 5 Visceral arterial ischemiaPTCTCAE E13847 Grade 5 Visceral arterial ischemia Grade 5 Vomiting NCIDeath Grade 5 VomitingPTCTCAE E11073 Grade 5 Vomiting Grade 5 Vulval infection NCIDeath Grade 5 Vulval infectionPTCTCAE E11634 Grade 5 Vulval infection Grade 5 Wheezing NCIDeath Grade 5 WheezingPTCTCAE E13610 Grade 5 Wheezing Grade 5 Wolff-Parkinson-White syndrome NCIDeath Grade 5 Wolff-Parkinson-White syndromePTCTCAE E10249 Grade 5 Wolff-Parkinson-White syndrome Grade 5 Wound complication NCIDeath Grade 5 Wound complicationPTCTCAE E12062 Grade 5 Wound complication Grade 5 Wound dehiscence NCIDeath Grade 5 Wound dehiscencePTCTCAE E12068 Grade 5 Wound dehiscence Grade 5 Wound infection NCIDeath Grade 5 Wound infectionPTCTCAE E11639 Grade 5 Wound infection Growth accelerated 10018746 NCIA disorder characterized by greater growth than expected for age. Growth acceleratedLLTMedDRA10018746 Growth acceleratedPTCTCAE C83495 E10317 Growth accelerated Growth hormone abnormal 10018748 NCIA finding based on laboratory test results that indicate abnormal levels of growth hormone in a biological specimen. Blood growth hormone abnormalLLTMedDRA10005572 GH abnormalLLTMedDRA10018223 Growth hormone abnormalLLTMedDRA10018748 Growth hormone abnormalPTCTCAE Plasma growth hormone abnormalLLTMedDRA10035312 Serum growth hormone abnormalLLTMedDRA10040280 Somatotrophin abnormal NOSLLTMedDRA10041332 Somatotropin abnormal NOSLLTMedDRA10041337 Somatotropin abnormalLLTMedDRA10041336 C78327 E12166 Growth hormone abnormal Growth suppression 10018761 NCIA disorder characterized by of stature that is smaller than normal as expected for age. Growth retardationLLTMedDRA10053759 Growth retardedLLTMedDRA10018760 Growth suppressionLLTMedDRA10018761 Growth suppressionPTCTCAE Height increase rate loweredLLTMedDRA10019371 Idiopathic short statureLLTMedDRA10066333 Staturo-ponderal retardationLLTMedDRA10066864 C78328 E12422 Growth suppression Gum infection 10018784 NCIA disorder characterized by an infectious process involving the gums. Gingival infectionLLTMedDRA10058802 Gingivitis infection NOSLLTMedDRA10018295 Gingivitis infectionLLTMedDRA10018294 Gum infectionLLTMedDRA10018784 Gum infectionPTCTCAE Infection of gumLLTMedDRA10021849 Suppuration gumLLTMedDRA10042584 C78329 E11400 Gum infection Gynecomastia 10018801 NCIA disorder characterized by excessive development of the breasts in males. Breast enlargement male bilateralLLTMedDRA10006245 Breast enlargement male unilateralLLTMedDRA10058697 Breast enlargement maleLLTMedDRA10006244 Enlargement breast maleLLTMedDRA10014844 Gynaecomastia aggravatedLLTMedDRA10048367 GynaecomastiaLLTMedDRA10018800 Gynecomastia aggravatedLLTMedDRA10055578 GynecomastiaLLTMedDRA10018801 GynecomastiaPTCTCAE C3073 E13115 Gynecomastia Hallucinations 10019077 NCIA disorder characterized by a false sensory perception in the absence of an external stimulus. Drug-induced hallucinosisLLTMedDRA10013761 HallucinatingLLTMedDRA10019062 Hallucination NOSLLTMedDRA10019066 HallucinationLLTMedDRA10019063 Hallucinations aggravatedLLTMedDRA10019078 HallucinationsLLTMedDRA10019077 HallucinationsPTCTCAE Kinesthetic hallucinationLLTMedDRA10023450 Organic hallucinosis syndromeLLTMedDRA10031079 PseudohallucinationLLTMedDRA10066297 Sensory hallucinationsLLTMedDRA10040028 Stump hallucinationLLTMedDRA10042263 C37961 E12919 Hallucinations Haptoglobin decreased 10019150 NCIA finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen. Haptoglobin decreasedLLTMedDRA10019150 Haptoglobin decreasedPTCTCAE Haptoglobin lowLLTMedDRA10019153 C78330 E12169 Haptoglobin decreased Head soft tissue necrosis 10065779 NCIA disorder characterized by a necrotic process occurring in the soft tissues of the head. Abdominal soft tissue necrosisLLTMedDRA10065775 Head soft tissue necrosisLLTMedDRA10065779 Head soft tissue necrosisPTCTCAE Neck soft tissue necrosisLLTMedDRA10065781 Pelvic soft tissue necrosisLLTMedDRA10065793 Soft tissue necrosis lower limbLLTMedDRA10065777 Soft tissue necrosis upper limbLLTMedDRA10065778 Soft tissue necrosisLLTMedDRA10065769 C78331 E12426 Head soft tissue necrosis Headache 10019211 NCIA disorder characterized by a sensation of marked discomfort in various parts of the head, not confined to the area of distribution of any nerve. CephalgiaLLTMedDRA10008013 Chronic headachesLLTMedDRA10053850 Drug-induced headacheLLTMedDRA10051385 Forehead headacheLLTMedDRA10016998 Frequent headachesLLTMedDRA10052403 Frontal headacheLLTMedDRA10048967 Fullness headLLTMedDRA10017468 Head fullnessLLTMedDRA10019195 Head painLLTMedDRA10019198 Head pressureLLTMedDRA10019200 Head throbbingLLTMedDRA10019204 Headache (except migraine) aggravatedLLTMedDRA10019212 Headache (excl migraine) aggravatedLLTMedDRA10056791 Headache NOS aggravatedLLTMedDRA10019219 Headache NOSLLTMedDRA10019218 Headache aggravatedLLTMedDRA10048567 Headache dullLLTMedDRA10019215 Headache fullnessLLTMedDRA10019216 Headache occurringLLTMedDRA10019220 Headache recurrentLLTMedDRA10066618 Headache temporalLLTMedDRA10019225 Headache transientLLTMedDRA10019227 HeadacheLLTMedDRA10019211 HeadachePTCTCAE Intermittent headacheLLTMedDRA10059296 Nocturnal headacheLLTMedDRA10029455 Occipital headacheLLTMedDRA10048968 Pain headLLTMedDRA10033405 Parietal headacheLLTMedDRA10048969 Pounding in headLLTMedDRA10036464 Premenstrual headacheLLTMedDRA10049122 Retroauricular painLLTMedDRA10063142 Temporal headacheLLTMedDRA10043208 Throbbing headacheLLTMedDRA10058140 C34661 E12678 Headache Hearing impaired 10019245 NCIA disorder characterized by partial or complete loss of the ability to detect or understand sounds resulting from damage to ear structures. Abnormal auditory perception, unspecifiedLLTMedDRA10000116 Auditory disorder (NOS)LLTMedDRA10003779 Auditory disorder NOSLLTMedDRA10003780 Auditory disorderLLTMedDRA10003778 Hearing impairedLLTMedDRA10019245 Hearing impairedPTCTCAE Hearing impairment aggravatedLLTMedDRA10048394 Impairment of auditory discriminationLLTMedDRA10021526 C50576 E10276 Hearing impaired Heart failure 10019279 NCIA disorder characterized by the inability of the heart to pump blood at an adequate volume to meet tissue metabolic requirements, or, the ability to do so only at an elevation in the filling pressure. Cardiac failure (NOS)LLTMedDRA10007555 Cardiac failure NOSLLTMedDRA10007562 Cardiac failure aggravatedLLTMedDRA10007557 Cardiac failureLLTMedDRA10007554 Cardiac function failedLLTMedDRA10007568 Cardiac function failureLLTMedDRA10007569 Cardiac insufficiencyLLTMedDRA10007582 Decompensated heart failureLLTMedDRA10066159 Decompensation cardiacLLTMedDRA10011949 Decompensation myocardialLLTMedDRA10011950 Failure heartLLTMedDRA10016145 Heart failure (NOS)LLTMedDRA10019282 Heart failure NYHA class ILLTMedDRA10064079 Heart failure NYHA class IILLTMedDRA10064080 Heart failure NYHA class IIILLTMedDRA10064081 Heart failure NYHA class IVLLTMedDRA10064082 Heart failure, unspecifiedLLTMedDRA10019285 Heart failureLLTMedDRA10019279 Heart failurePTCTCAE Heart insufficiencyLLTMedDRA10019290 Insufficiency cardiacLLTMedDRA10022462 Myocardial contraction decreasedLLTMedDRA10028587 Myocardial decompensationLLTMedDRA10028588 Recurrent cardiac decompensationLLTMedDRA10066496 C50577 E10124 Heart failure Hematoma 10019428 NCIA disorder characterized by a localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of a blood vessel. Haematoma NOSLLTMedDRA10018854 HaematomaLLTMedDRA10018852 Hematoma NOSLLTMedDRA10019434 HematomaLLTMedDRA10019428 HematomaPTCTCAE C50579 E13775 Hematoma Hematosalpinx 10060602 NCIA disorder characterized by the presence of blood in a fallopian tube. HaematosalpinxLLTMedDRA10050468 HematosalpinxLLTMedDRA10060602 HematosalpinxPTCTCAE C78332 E13119 Hematosalpinx Hematuria 10019450 NCIA disorder characterized by laboratory test results that indicate blood in the urine. Chronic haematuriaLLTMedDRA10066621 Chronic hematuriaLLTMedDRA10066620 ErythrocyturiaLLTMedDRA10050784 Frank haematuriaLLTMedDRA10017332 Frank hematuriaLLTMedDRA10060539 Haematuria aggravatedLLTMedDRA10048402 Haematuria microscopicLLTMedDRA10018869 HaematuriaLLTMedDRA10018867 Hematuria aggravatedLLTMedDRA10060604 Hematuria microscopicLLTMedDRA10060605 HematuriaLLTMedDRA10019450 HematuriaPTCTCAE Macroscopic haematuriaLLTMedDRA10059802 Macroscopic hematuriaLLTMedDRA10059823 Microscopic haematuriaLLTMedDRA10027552 Microscopic hematuriaLLTMedDRA10059824 C3090 E13000 Hematuria Hemoglobin increased 10055599 NCIA finding based on laboratory test results that indicate increased levels of hemoglobin in a biological specimen. Haemoglobin highLLTMedDRA10018887 Haemoglobin increasedLLTMedDRA10018888 Hemoglobin highLLTMedDRA10055598 Hemoglobin increasedLLTMedDRA10055599 Hemoglobin increasedPTCTCAE C78333 E12171 Hemoglobin increased Hemoglobinuria 10019489 NCIA disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine. Haemoglobinuria due to haemolysis from external causesLLTMedDRA10018908 HaemoglobinuriaLLTMedDRA10018906 Hemoglobinuria due to hemolysis from external causesLLTMedDRA10019490 HemoglobinuriaLLTMedDRA10019489 HemoglobinuriaPTCTCAE C34677 E13006 Hemoglobinuria Hemolysis 10019491 NCIA disorder characterized by laboratory test results that indicate widespread erythrocyte cell membrane destruction. Haemolysis NOSLLTMedDRA10018914 Haemolysis aggravatedLLTMedDRA10048431 HaemolysisLLTMedDRA10018910 Haemolytic reactionLLTMedDRA10018930 Hemolysis aggravatedLLTMedDRA10060608 HemolysisLLTMedDRA10019491 HemolysisPTCTCAE Hemolytic reactionLLTMedDRA10019514 C37965 E10037 Hemolysis Hemolytic uremic syndrome 10019515 NCIA disorder characterized by a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia. Haemolytic uraemic syndromeLLTMedDRA10018932 Haemolytic-uraemic syndromeLLTMedDRA10018933 Hemolytic uremic syndromeLLTMedDRA10019515 Hemolytic uremic syndromePTCTCAE Hemolytic-uremic syndromeLLTMedDRA10019516 Syndrome haemolytic uraemicLLTMedDRA10060422 Syndrome hemolytic uremicLLTMedDRA10042814 C75545 E10043 Hemolytic uremic syndrome Hemorrhoidal hemorrhage 10060640 NCIA disorder characterized by bleeding from the hemorrhoids. Bleeding pilesLLTMedDRA10005126 Haemorrhoid bleeding friction rubLLTMedDRA10051309 Haemorrhoidal bleedingLLTMedDRA10053553 Haemorrhoidal haemorrhageLLTMedDRA10054787 Hemorrhoid bleeding friction rubLLTMedDRA10060637 Hemorrhoidal bleedingLLTMedDRA10019609 Hemorrhoidal hemorrhageLLTMedDRA10060640 Hemorrhoidal hemorrhagePTCTCAE C78337 E10767 Hemorrhoidal hemorrhage Hemorrhoids 10019611 NCIA disorder characterized by the presence of dilated veins in the rectum and surrounding area. Anorectal thrombophlebitisLLTMedDRA10064201 External haemorrhoids without mention of complicationLLTMedDRA10015745 External haemorrhoidsLLTMedDRA10015743 External hemorrhoids without mention of complicationLLTMedDRA10015748 External hemorrhoidsLLTMedDRA10015746 External pilesLLTMedDRA10015755 External thrombosed haemorrhoidsLLTMedDRA10015756 External thrombosed hemorrhoidsLLTMedDRA10015757 First degree haemorrhoidsLLTMedDRA10016701 First degree hemorrhoidsLLTMedDRA10016702 Haemorrhoidal crisisLLTMedDRA10068589 Haemorrhoids aggravatedLLTMedDRA10048363 Haemorrhoids necrosisLLTMedDRA10050449 Haemorrhoids thrombosedLLTMedDRA10019023 HaemorrhoidsLLTMedDRA10019022 Hemorrhoidal crisisLLTMedDRA10068594 Hemorrhoids aggravatedLLTMedDRA10060641 Hemorrhoids necrosisLLTMedDRA10060642 Hemorrhoids thrombosedLLTMedDRA10019612 HemorrhoidsLLTMedDRA10019611 HemorrhoidsPTCTCAE Internal haemorrhoids without mention of complicationLLTMedDRA10022579 Internal haemorrhoidsLLTMedDRA10022577 Internal hemorrhoids without mention of complicationLLTMedDRA10022582 Internal hemorrhoidsLLTMedDRA10022580 Internal pilesLLTMedDRA10022588 Internal thrombosed haemorrhoidsLLTMedDRA10022589 Internal thrombosed hemorrhoidsLLTMedDRA10022590 PilesLLTMedDRA10035037 Prolapsed haemorrhoidLLTMedDRA10036851 Prolapsed hemorrhoidLLTMedDRA10060659 Residual haemorrhoidal skin tagsLLTMedDRA10038626 Residual hemorrhoidal skin tagsLLTMedDRA10038627 Second degree haemorrhoidsLLTMedDRA10039799 Second degree hemorrhoidsLLTMedDRA10060661 Third degree haemorrhoidsLLTMedDRA10043442 Third degree hemorrhoidsLLTMedDRA10043443 Thrombosed haemorrhoids (NOS)LLTMedDRA10043601 Thrombosed hemorrhoids (NOS)LLTMedDRA10043602 Thrombosed piles externalLLTMedDRA10043603 Thrombosed piles internalLLTMedDRA10043604 Unspecified haemorrhoids without mention of complicationLLTMedDRA10045899 Unspecified hemorrhoids without mention of complicationLLTMedDRA10045909 Unspecified thrombosed haemorrhoidsLLTMedDRA10046181 Unspecified thrombosed hemorrhoidsLLTMedDRA10046182 C26792 E10773 Hemorrhoids Hepatic failure 10019663 NCIA disorder characterized by the inability of the liver to metabolize chemicals in the body. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, and alkaline phosphatase. Hepatic failurePTCTCAE C26922 E11211 Hepatic failure Hepatic hemorrhage 10019678 NCIA disorder characterized by bleeding from the liver. Haemorrhage of liverLLTMedDRA10055830 Hemorrhage of liverLLTMedDRA10019569 Hepatic haemorrhageLLTMedDRA10019677 Hepatic hemorrhageLLTMedDRA10019678 Hepatic hemorrhagePTCTCAE C78338 E11215 Hepatic hemorrhage Hepatic infection 10056522 NCIA disorder characterized by an infectious process involving the liver. Hepatic infectionLLTMedDRA10056522 Hepatic infectionPTCTCAE C78339 E11406 Hepatic infection Hepatic necrosis 10019692 NCIA disorder characterized by a necrotic process occurring in the hepatic parenchyma. Hepatic lobule necrosisLLTMedDRA10019684 Hepatic necrosis extensiveLLTMedDRA10019693 Hepatic necrosisLLTMedDRA10019692 Hepatic necrosisPTCTCAE Hepatitis necrotisingLLTMedDRA10056217 Hepatitis necrotizingLLTMedDRA10019784 Liver necrosisLLTMedDRA10024701 Necrosis hepatocellularLLTMedDRA10028859 Necrosis liver focalLLTMedDRA10028868 Necrosis liverLLTMedDRA10028867 Subacute hepatic necrosisLLTMedDRA10042277 C78340 E11221 Hepatic necrosis Hepatic pain 10019705 NCIA disorder characterized by a sensation of marked discomfort in the liver region. Hepatic painLLTMedDRA10019705 Hepatic painPTCTCAE Hepatobiliary painLLTMedDRA10057960 Liver painLLTMedDRA10024703 C78341 E11224 Hepatic pain Hepatitis viral 10019799 NCIA disorder characterized by a viral pathologic process involving the liver parenchyma. Hepatitis viral NOSLLTMedDRA10019800 Hepatitis viral-likeLLTMedDRA10019801 Hepatitis viralLLTMedDRA10019799 Hepatitis viralPTCTCAE Viral hepatitis NOSLLTMedDRA10047459 Viral hepatitisLLTMedDRA10047446 Virus hepatitisLLTMedDRA10047489 C35124 E11410 Hepatitis viral Hepatobiliary disorders 10019805 Hepatobiliary disordersPTCTCAE E13869 Hepatobiliary disorders Hepatobiliary disorders - Other, specify Hepatobiliary disorders - Other, specifyPTCTCAE E11228 Hepatobiliary disorders - Other, specify Hiccups 10020039 NCIA disorder characterized by repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm. HiccoughLLTMedDRA10020037 HiccupLLTMedDRA10020038 HiccupsLLTMedDRA10020039 HiccupsPTCTCAE Intractable hiccupsLLTMedDRA10066097 SingultationLLTMedDRA10040732 SingultousLLTMedDRA10040733 SingultusLLTMedDRA10040734 C37966 E13380 Hiccups Hip fracture 10020100 NCIA finding of traumatic injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken. Hip fracturePTCTCAE C26794 E11726 Hip fracture Hirsutism 10020112 NCIA disorder characterized by the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen) HirsutismPTCTCAE C61444 E13642 Hirsutism Hoarseness 10020201 NCIA disorder characterized by harsh and raspy voice arising from or spreading to the larynx. Distorted voiceLLTMedDRA10013483 Disturbance in loudnessLLTMedDRA10013499 DysphoniaLLTMedDRA10013952 Hoarse voiceLLTMedDRA10020200 Hoarseness of voiceLLTMedDRA10020202 HoarsenessLLTMedDRA10020201 HoarsenessPTCTCAE Phonation difficultyLLTMedDRA10034924 Resonance disorderLLTMedDRA10038641 Vocal tone disorderLLTMedDRA10047677 Vocal volume disorderLLTMedDRA10047678 Voice alterationLLTMedDRA10047681 Voice disturbance, unspecifiedLLTMedDRA10047683 Voice disturbanceLLTMedDRA10047682 Voice loweredLLTMedDRA10047684 C47813 E13384 Hoarseness Hot flashes 10020407 NCIA disorder characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling. Aggravation of hot flushesLLTMedDRA10001485 Exacerbation of hot flushesLLTMedDRA10015577 Feeling of hot flushesLLTMedDRA10016350 Flash hotLLTMedDRA10016752 Flush hotLLTMedDRA10016820 Hot flashesLLTMedDRA10020407 Hot flashesPTCTCAE Hot flushLLTMedDRA10060800 Hot flushes NOSLLTMedDRA10020413 Hot flushes aggravatedLLTMedDRA10020409 Hot flushes facialLLTMedDRA10020410 Hot flushes non-menopausalLLTMedDRA10020412 Hot flushes of legsLLTMedDRA10020414 Hot flushes of trunkLLTMedDRA10020415 Hot flushes transient of faceLLTMedDRA10020416 Hot flushesLLTMedDRA10020408 C3109 E13781 Hot flashes Hydrocephalus 10020508 NCIA disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain. Communicating hydrocephalusLLTMedDRA10010116 Hydrocephalus NOSLLTMedDRA10020512 Hydrocephalus acquiredLLTMedDRA10020510 HydrocephalusLLTMedDRA10020508 HydrocephalusPTCTCAE Hydrocephaly communicativeLLTMedDRA10020514 Hydrocephaly obstructiveLLTMedDRA10020516 HydrocephalyLLTMedDRA10020513 Obstructive hydrocephalusLLTMedDRA10029981 C3111 E12682 Hydrocephalus Hypercalcemia 10020587 NCIA disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium (corrected for albumin) in blood. Hypercalcaemia aggravatedLLTMedDRA10048372 HypercalcaemiaLLTMedDRA10020583 Hypercalcemia aggravatedLLTMedDRA10054403 HypercalcemiaLLTMedDRA10020587 HypercalcemiaPTCTCAE C3112 E12270 Hypercalcemia Hyperglycemia 10020639 NCIA disorder characterized by laboratory test results that indicate an elevation in the concentration of blood sugar. It is usually an indication of diabetes mellitus or glucose intolerance. Drug-induced hyperglycaemiaLLTMedDRA10013704 Drug-induced hyperglycemiaLLTMedDRA10060588 Fasting hyperglycaemiaLLTMedDRA10068939 Fasting hyperglycemiaLLTMedDRA10068938 Hyperglycaemia NOSLLTMedDRA10020637 Hyperglycaemia drug-inducedLLTMedDRA10020636 Hyperglycaemia steroid-inducedLLTMedDRA10051346 HyperglycaemiaLLTMedDRA10020635 Hyperglycemia drug-inducedLLTMedDRA10060487 Hyperglycemia steroid-inducedLLTMedDRA10060488 HyperglycemiaLLTMedDRA10020639 HyperglycemiaPTCTCAE Stress induced hyperglycaemiaLLTMedDRA10060439 Stress induced hyperglycemiaLLTMedDRA10042216 C26797 E12276 Hyperglycemia Hyperhidrosis 10020642 NCIA disorder characterized by excessive perspiration. DiaphoresisLLTMedDRA10012703 Drenching sweatsLLTMedDRA10013635 Excess sweatingLLTMedDRA10015590 Heavy sweatingLLTMedDRA10019362 HyperhidrosisLLTMedDRA10020642 HyperhidrosisPTCTCAE Perspiration excessiveLLTMedDRA10034734 Plantar hyperhidrosisLLTMedDRA10066425 Sudation increasedLLTMedDRA10066455 SudoresisLLTMedDRA10067146 Sweating attackLLTMedDRA10042663 Sweating easilyLLTMedDRA10042665 Sweating increased armpitsLLTMedDRA10042668 Sweating increased palmsLLTMedDRA10042669 Sweating increasedLLTMedDRA10042667 SweatingLLTMedDRA10042661 Sweaty handsLLTMedDRA10062661 SweatyLLTMedDRA10042670 C78345 E13645 Hyperhidrosis Hyperkalemia 10020647 NCIA disorder characterized by laboratory test results that indicate an elevation in the concentration of potassium in the blood; associated with kidney failure or sometimes with the use of diuretic drugs. HyperkalaemiaLLTMedDRA10020646 HyperkalemiaLLTMedDRA10020647 HyperkalemiaPTCTCAE HyperpotassaemiaLLTMedDRA10020735 HyperpotassemiaLLTMedDRA10020736 C37968 E12282 Hyperkalemia Hypermagnesemia 10020670 NCIA disorder characterized by laboratory test results that indicate an elevation in the concentration of magnesium in the blood. HypermagnesaemiaLLTMedDRA10020669 HypermagnesemiaLLTMedDRA10020670 HypermagnesemiaPTCTCAE C37969 E12288 Hypermagnesemia Hypernatremia 10020680 NCIA disorder characterized by laboratory test results that indicate an elevation in the concentration of sodium in the blood. HypernatraemiaLLTMedDRA10020679 HypernatremiaLLTMedDRA10020680 HypernatremiaPTCTCAE Salt retentionLLTMedDRA10039478 C37970 E12293 Hypernatremia Hyperparathyroidism 10020705 NCIA disorder characterized by an increase in production of parathyroid hormone by the parathyroid glands. This results in hypercalcemia (abnormally high levels of calcium in the blood). Hyperparathyroidism NOSLLTMedDRA10020706 HyperparathyroidismLLTMedDRA10020705 HyperparathyroidismPTCTCAE C48259 E10319 Hyperparathyroidism Hypersomnia 10020765 NCIA disorder characterized by characterized by excessive sleepiness during the daytime. HypersomniaLLTMedDRA10020765 HypersomniaPTCTCAE Persistent disorder of initiating or maintaining wakefulnessLLTMedDRA10034706 Primary hypersomniaLLTMedDRA10036694 Sleep excessiveLLTMedDRA10041000 Transient disorder of initiating or maintaining wakefulnessLLTMedDRA10044378 C78346 E12688 Hypersomnia Hypertension 10020772 NCIA disorder characterized by a pathological increase in blood pressure; a repeatedly elevation in the blood pressure exceeding 140 over 90 mm Hg. Blood pressure highLLTMedDRA10005747 Blood pressure increased refractoryLLTMedDRA10005751 Borderline hypertensionLLTMedDRA10057495 Hypertension NOSLLTMedDRA10020782 Hypertension aggravatedLLTMedDRA10020773 Hypertension arterialLLTMedDRA10020775 Hypertension exacerbatedLLTMedDRA10020779 Hypertension not adequately controlledLLTMedDRA10020783 Hypertension paroxysmalLLTMedDRA10020785 Hypertension worsenedLLTMedDRA10020799 HypertensionLLTMedDRA10020772 HypertensionPTCTCAE Hypertensive episodeLLTMedDRA10020804 Hypertensive episodesLLTMedDRA10020805 HypertensiveLLTMedDRA10020800 Increased BP slipping out of controlLLTMedDRA10021657 Refractory hypertensionLLTMedDRA10038274 Uncomplicated hypertensionLLTMedDRA10045477 Uncontrolled hypertensionLLTMedDRA10066860 Unspecified antepartum hypertensionLLTMedDRA10045637 Unspecified postpartum hypertensionLLTMedDRA10046111 White coat hypertensionLLTMedDRA10051581 C3117 E13785 Hypertension Hyperthyroidism 10020850 NCIA disorder characterized by excessive levels of thyroid hormone in the body. Common causes include an overactive thyroid gland or thyroid hormone overdose. Hyperthyroidism aggravatedLLTMedDRA10020851 HyperthyroidismLLTMedDRA10020850 HyperthyroidismPTCTCAE Iodine hyperthyroidismLLTMedDRA10068169 Latent hyperthyroidismLLTMedDRA10059243 Thyrotoxicosis aggravatedLLTMedDRA10043790 Thyrotoxicosis from ectopic thyroid noduleLLTMedDRA10043791 Thyrotoxicosis with goitreLLTMedDRA10043797 Thyrotoxicosis without goitreLLTMedDRA10043800 ThyrotoxicosisLLTMedDRA10043789 C3123 E10322 Hyperthyroidism Hypertrichosis 10020864 NCIA disorder characterized by hair density or length beyond the accepted limits of normal in a particular body region, for a particular age or race. Body hair increasedLLTMedDRA10053924 Hypertrichosis aggravatedLLTMedDRA10020865 Hypertrichosis genitalLLTMedDRA10020867 Hypertrichosis of eyelidLLTMedDRA10020868 HypertrichosisLLTMedDRA10020864 HypertrichosisPTCTCAE C79597 E13649 Hypertrichosis Hypertriglyceridemia 10020870 NCIA disorder characterized by laboratory test results that indicate an elevation in the concentration of triglyceride concentration in the blood. HyperglyceridaemiaLLTMedDRA10051173 HyperglyceridemiaLLTMedDRA10054411 HypertriglyceridaemiaLLTMedDRA10020869 HypertriglyceridemiaLLTMedDRA10020870 HypertriglyceridemiaPTCTCAE Pure hyperglyceridaemiaLLTMedDRA10037541 Pure hyperglyceridemiaLLTMedDRA10037542 C37971 E12299 Hypertriglyceridemia Hyperuricemia 10020907 NCIA disorder characterized by laboratory test results that indicate an elevation in the concentration of uric acid. HyperuricaemiaLLTMedDRA10020903 HyperuricaemicLLTMedDRA10020904 HyperuricemiaLLTMedDRA10020907 HyperuricemiaPTCTCAE C3961 E12305 Hyperuricemia Hypoalbuminemia 10020943 NCIA disorder characterized by laboratory test results that indicate a low concentration of albumin in the blood. HypoalbuminaemiaLLTMedDRA10020942 HypoalbuminemiaLLTMedDRA10020943 HypoalbuminemiaPTCTCAE C37972 E12310 Hypoalbuminemia Hypocalcemia 10020949 NCIA disorder characterized by laboratory test results that indicate a low concentration of calcium (corrected for albumin) in the blood. HypocalcaemiaLLTMedDRA10020947 HypocalcemiaLLTMedDRA10020949 HypocalcemiaPTCTCAE C37973 E12316 Hypocalcemia Hypoglossal nerve disorder 10061212 NCIA disorder characterized by involvement of the hypoglossal nerve (twelfth cranial nerve). Hypoglossal nerve disorder NOSLLTMedDRA10020991 Hypoglossal nerve disorderLLTMedDRA10061212 Hypoglossal nerve disorderPTCTCAE C26954 E12692 Hypoglossal nerve disorder Hypoglycemia 10021005 NCIA disorder characterized by laboratory test results that indicate a low concentration of glucose in the blood. Hypoglycaemia NOSLLTMedDRA10020996 Hypoglycaemia aggravatedLLTMedDRA10048374 Hypoglycaemia nightLLTMedDRA10020995 Hypoglycaemia, unspecifiedLLTMedDRA10020998 HypoglycaemiaLLTMedDRA10020993 Hypoglycaemic attackLLTMedDRA10020999 Hypoglycaemic episodeLLTMedDRA10060385 Hypoglycaemic reactionLLTMedDRA10021003 Hypoglycemia aggravatedLLTMedDRA10054428 Hypoglycemia nightLLTMedDRA10060490 Hypoglycemia, unspecifiedLLTMedDRA10021007 HypoglycemiaLLTMedDRA10021005 HypoglycemiaPTCTCAE Hypoglycemic attackLLTMedDRA10060550 Hypoglycemic episodeLLTMedDRA10049635 Hypoglycemic reactionLLTMedDRA10021009 Insulin hypoglycaemiaLLTMedDRA10022484 Insulin hypoglycemiaLLTMedDRA10022485 Ketotic hypoglycaemiaLLTMedDRA10057214 Ketotic hypoglycemiaLLTMedDRA10057216 Postprandial hypoglycaemiaLLTMedDRA10059035 Postprandial hypoglycemiaLLTMedDRA10059038 Reaction hypoglycaemicLLTMedDRA10060409 Reaction hypoglycemicLLTMedDRA10037949 C3126 E12322 Hypoglycemia Hypohidrosis 10021013 NCIA disorder characterized by reduced sweating. HyphidrosisLLTMedDRA10020926 HypohidrosisLLTMedDRA10021013 HypohidrosisPTCTCAE Sweating decreasedLLTMedDRA10042664 C34718 E13652 Hypohidrosis Hypokalemia 10021018 NCIA disorder characterized by laboratory test results that indicate a low concentration of potassium in the blood. HypokalaemiaLLTMedDRA10021015 HypokalemiaLLTMedDRA10021018 HypokalemiaPTCTCAE HypopotassaemiaLLTMedDRA10021080 HypopotassemiaLLTMedDRA10021081 Potassium deficiencyLLTMedDRA10036445 C37974 E12327 Hypokalemia Hypomagnesemia 10021028 NCIA disorder characterized by laboratory test results that indicate a low concentration of magnesium in the blood. HypomagnesaemiaLLTMedDRA10021027 HypomagnesemiaLLTMedDRA10021028 HypomagnesemiaPTCTCAE C37975 E12333 Hypomagnesemia Hyponatremia 10021038 NCIA disorder characterized by laboratory test results that indicate a low concentration of sodium in the blood. Hyponatraemia aggravatedLLTMedDRA10048375 HyponatraemiaLLTMedDRA10021036 HyponatraemicLLTMedDRA10060380 Hyponatremia aggravatedLLTMedDRA10054430 HyponatremiaLLTMedDRA10021038 HyponatremiaPTCTCAE HyponatremicLLTMedDRA10021039 Na+ depletionLLTMedDRA10028670 Salt deficiencyLLTMedDRA10039475 Salt depletionLLTMedDRA10039476 Sodium depletionLLTMedDRA10041270 C37976 E12339 Hyponatremia Hypoparathyroidism 10021041 NCIA disorder characterized by a decrease in production of parathyroid hormone by the parathyroid glands. HypoparathyroidismLLTMedDRA10021041 HypoparathyroidismPTCTCAE C78350 E10328 Hypoparathyroidism Hypophosphatemia 10021059 NCIA disorder characterized by laboratory test results that indicate a low concentration of phosphates in the blood. HypophosphataemiaLLTMedDRA10021058 HypophosphatemiaLLTMedDRA10021059 HypophosphatemiaPTCTCAE C37977 E12344 Hypophosphatemia Hypotension 10021097 NCIA disorder characterized by a blood pressure that is below the normal expected for an individual in a given environment. Acute hypotensionLLTMedDRA10049705 Arterial hypotensionLLTMedDRA10066331 Blood pressure lowLLTMedDRA10005753 Chronic hypotensionLLTMedDRA10008921 Hypotension NOSLLTMedDRA10021099 Hypotension aggravatedLLTMedDRA10048348 Hypotension asymptomaticLLTMedDRA10021098 Hypotension paroxysmLLTMedDRA10021103 Hypotension symptomaticLLTMedDRA10021105 Hypotension, unspecifiedLLTMedDRA10021106 HypotensionLLTMedDRA10021097 HypotensionPTCTCAE Hypotensive episodeLLTMedDRA10021108 HypotensiveLLTMedDRA10021107 Iatrogenic hypotensionLLTMedDRA10021178 Low BPLLTMedDRA10024896 Low blood pressureLLTMedDRA10024895 Maternal hypotension syndrome, antepartumLLTMedDRA10026928 Maternal hypotension syndrome, postpartumLLTMedDRA10026929 Maternal hypotension syndromeLLTMedDRA10026926 PreshockLLTMedDRA10051586 Transient systolic hypotensionLLTMedDRA10065409 C3128 E13791 Hypotension Hypothermia 10021113 NCIA disorder characterized by an abnormally low body temperature. Treatment is required when the body temperature is 35C (95F) or below. HypothermiaLLTMedDRA10021113 HypothermiaPTCTCAE C78351 E11122 Hypothermia Hypothyroidism 10021114 NCIA disorder characterized by a decrease in production of thyroid hormone by the thyroid gland. Acquired hypothyroidismLLTMedDRA10000559 HypothyroidismLLTMedDRA10021114 HypothyroidismPTCTCAE Iodine hypothyroidismLLTMedDRA10022908 Latent hypothyroidismLLTMedDRA10059244 Myxedema juvenileLLTMedDRA10028664 Myxoedema juvenileLLTMedDRA10055944 Subclinical hypothyroidismLLTMedDRA10064627 Thyroid activity decreasedLLTMedDRA10043686 Thyroid function decreasedLLTMedDRA10043727 Unspecified hypothyroidismLLTMedDRA10045920 C26800 E10334 Hypothyroidism Hypoxia 10021143 NCIA disorder characterized by a decrease in the level of oxygen in the body. HypoxaemiaLLTMedDRA10021141 HypoxemiaLLTMedDRA10021142 HypoxiaLLTMedDRA10021143 HypoxiaPTCTCAE HypoxicLLTMedDRA10021144 C3890 E13388 Hypoxia INR increased 10022402 NCIA finding based on laboratory test results that indicate an increase in the ratio of the patient's prothrombin time to a control sample in the blood. INR increasedPTCTCAE C78366 E12175 INR increased IVth nerve disorder 10065836 NCIA disorder characterized by involvement of the trochlear nerve (fourth cranial nerve). IVth nerve disorderLLTMedDRA10065836 IVth nerve disorderPTCTCAE C78395 E12705 IVth nerve disorder Ileal fistula 10065728 NCIA disorder characterized by an abnormal communication between the ileum and another organ or anatomic site. Ileal fistulaLLTMedDRA10065728 Ileal fistulaPTCTCAE Ileorectal fistulaLLTMedDRA10056993 C78352 E10777 Ileal fistula Ileal hemorrhage 10055287 NCIA disorder characterized by bleeding from the ileal wall. Duodenal bleedingLLTMedDRA10013814 Duodenal haemorrhageLLTMedDRA10013829 Duodenal hemorrhageLLTMedDRA10055242 Haemorrhage duodenumLLTMedDRA10055804 Haemorrhage ileumLLTMedDRA10055812 Haemorrhage jejunumLLTMedDRA10055819 Haemorrhage of ileumLLTMedDRA10055828 Haemorrhage of jejunumLLTMedDRA10055829 Hemorrhage duodenumLLTMedDRA10019534 Hemorrhage ileumLLTMedDRA10019546 Hemorrhage jejunumLLTMedDRA10019556 Hemorrhage of ileumLLTMedDRA10019567 Hemorrhage of jejunumLLTMedDRA10019568 Ileal haemorrhageLLTMedDRA10021301 Ileal hemorrhageLLTMedDRA10055287 Ileal hemorrhagePTCTCAE Jejunal haemorrhageLLTMedDRA10023173 Jejunal hemorrhageLLTMedDRA10055300 Small intestinal haemorrhageLLTMedDRA10052535 Small intestinal hemorrhageLLTMedDRA10055337 C78353 E10783 Ileal hemorrhage Ileal obstruction 10065730 NCIA disorder characterized by blockage of the normal flow of the intestinal contents in the ileum. Ileal obstructionLLTMedDRA10065730 Ileal obstructionPTCTCAE Jejunal obstructionLLTMedDRA10065732 Obstruction small intestineLLTMedDRA10029969 Partial small intestinal obstructionLLTMedDRA10056357 Small bowel obstructionLLTMedDRA10041055 Small intestinal obstruction NOSLLTMedDRA10041102 Small intestinal obstructionLLTMedDRA10041101 Small intestine obstructionLLTMedDRA10041129 C78354 E10789 Ileal obstruction Ileal perforation 10021305 NCIA disorder characterized by a rupture in the ileal wall. Ileal perforationLLTMedDRA10021305 Ileal perforationPTCTCAE Perforation ilealLLTMedDRA10034412 C78355 E10795 Ileal perforation Ileal stenosis 10021307 NCIA disorder characterized by a narrowing of the lumen of the ileum. Ileal stenosisLLTMedDRA10021307 Ileal stenosisPTCTCAE Ileal strictureLLTMedDRA10021308 Stenosis ileumLLTMedDRA10041979 Stenosis of ileumLLTMedDRA10041984 Stricture of ileumLLTMedDRA10042236 C78356 E10800 Ileal stenosis Ileal ulcer 10021309 NCIA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the ileum. Ileal ulcerLLTMedDRA10021309 Ileal ulcerPTCTCAE Ileocaecal ulcerLLTMedDRA10057943 Ileocecal ulcerLLTMedDRA10057942 Ulcer ileumLLTMedDRA10045310 Ulcer of ileumLLTMedDRA10045324 C78357 E10806 Ileal ulcer Ileus 10021328 NCIA disorder characterized by failure of the ileum to transport intestinal contents. Ileus adhesiveLLTMedDRA10056322 Ileus of bowelLLTMedDRA10021330 Ileus of colonLLTMedDRA10021331 Ileus of intestineLLTMedDRA10021332 IleusLLTMedDRA10021328 IleusPTCTCAE C37979 E10812 Ileus Immune system disorders 10021428 Immune system disordersPTCTCAE E13871 Immune system disorders Immune system disorders - Other, specify Immune system disorders - Other, specifyPTCTCAE E11270 Immune system disorders - Other, specify Infections and infestations 10021881 Infections and infestationsPTCTCAE E13863 Infections and infestations Infections and infestations - Other, specify Infections and infestations - Other, specifyPTCTCAE E11415 Infections and infestations - Other, specify Infective myositis 10021918 NCIA disorder characterized by an infectious process involving the skeletal muscles. Infective myositisLLTMedDRA10021918 Infective myositisPTCTCAE C26984 E11421 Infective myositis Infusion related reaction 10051792 NCIA disorder characterized by adverse reaction to the infusion of pharmacological or biological substances. Infusion associated chillsLLTMedDRA10059088 Infusion associated discomfortLLTMedDRA10059090 Infusion associated sensation of coldLLTMedDRA10059087 Infusion associated shiveringLLTMedDRA10059089 Infusion associated symptomsLLTMedDRA10051789 Infusion related painLLTMedDRA10065672 Infusion related reactionLLTMedDRA10051792 Infusion related reactionPTCTCAE C78361 E11127 Infusion related reaction Infusion site extravasation 10064774 NCIA disorder characterized by leakage of a pharmacologic or a biologic substance from the infusion site into the surrounding tissue. Signs and symptoms include induration, erythema, swelling, burning sensation and marked discomfort at the infusion site. Infusion site extravasationLLTMedDRA10064774 Infusion site extravasationPTCTCAE Infusion site infiltrationLLTMedDRA10059453 Infusion site leakingLLTMedDRA10064820 C78362 E11133 Infusion site extravasation Injection site reaction 10022095 NCIA disorder characterized by an intense adverse reaction (usually immunologic) developing at the site of an injection. Injection site macerationLLTMedDRA10058716 Injection site muscle reactionLLTMedDRA10062643 Injection site reaction NOSLLTMedDRA10022096 Injection site reactionLLTMedDRA10022095 Injection site reactionPTCTCAE Reaction injection site (NOS)LLTMedDRA10037950 C3508 E11138 Injection site reaction Injury, poisoning and procedural complications 10022117 Injury, poisoning and procedural complicationsPTCTCAE E13849 Injury, poisoning and procedural complications Injury, poisoning and procedural complications - Other, specify Injury, poisoning and procedural complications - Other, specifyPTCTCAE E11747 Injury, poisoning and procedural complications - Other, specify Injury to carotid artery 10022161 NCIA finding of damage to the carotid artery. Arterial injuryLLTMedDRA10003162 Femoral artery injuryLLTMedDRA10016429 Injury to anterior tibial arteryLLTMedDRA10022133 Injury to axillary arteryLLTMedDRA10022139 Injury to carotid artery, unspecifiedLLTMedDRA10022162 Injury to carotid arteryLLTMedDRA10022161 Injury to carotid arteryPTCTCAE Injury to common carotid arteryLLTMedDRA10022172 Injury to common femoral arteryLLTMedDRA10022173 Injury to external carotid arteryLLTMedDRA10022188 Injury to gastric arteryLLTMedDRA10022194 Injury to hepatic arteryLLTMedDRA10022202 Injury to hypogastric arteryLLTMedDRA10022204 Injury to iliac arteryLLTMedDRA10022207 Injury to inferior mesenteric arteryLLTMedDRA10022211 Injury to internal carotid arteryLLTMedDRA10022218 Injury to ovarian arteryLLTMedDRA10022291 Injury to palmar arteryLLTMedDRA10022293 Injury to popliteal arteryLLTMedDRA10022308 Injury to posterior tibial arteryLLTMedDRA10022314 Injury to primary branches of superior mesenteric arteryLLTMedDRA10022317 Injury to pulmonary arteryLLTMedDRA10022318 Injury to renal arteryLLTMedDRA10022327 Injury to splenic arteryLLTMedDRA10022348 Injury to superficial femoral arteryLLTMedDRA10022352 Injury to superior mesenteric artery (trunk)LLTMedDRA10022354 Injury to uterine arteryLLTMedDRA10022385 Radial artery injuryLLTMedDRA10037745 C79599 E11730 Injury to carotid artery Injury to inferior vena cava 10022213 NCIA finding of damage to the inferior vena cava. Injury to inferior vena cava, unspecifiedLLTMedDRA10022214 Injury to inferior vena cavaLLTMedDRA10022213 Injury to inferior vena cavaPTCTCAE Injury to superior vena cavaLLTMedDRA10022356 Vena cava injuryLLTMedDRA10047194 C78363 E11734 Injury to inferior vena cava Injury to jugular vein 10065849 NCIA finding of damage to the jugular vein. Injury to anterior tibial veinLLTMedDRA10022134 Injury to axillary veinLLTMedDRA10022142 Injury to external jugular veinLLTMedDRA10022189 Injury to hepatic veinsLLTMedDRA10022203 Injury to hypogastric veinLLTMedDRA10022205 Injury to iliac veinLLTMedDRA10022209 Injury to inferior mesenteric veinLLTMedDRA10022212 Injury to innominate and subclavian veinsLLTMedDRA10022216 Injury to internal jugular veinLLTMedDRA10022219 Injury to jugular veinLLTMedDRA10065849 Injury to jugular veinPTCTCAE Injury to ovarian veinLLTMedDRA10022292 Injury to popliteal veinLLTMedDRA10022310 Injury to portal veinLLTMedDRA10022313 Injury to posterior tibial veinLLTMedDRA10022316 Injury to pulmonary veinLLTMedDRA10022321 Injury to renal veinLLTMedDRA10022329 Injury to splenic veinLLTMedDRA10022349 Injury to uterine veinLLTMedDRA10022386 Venous injuryLLTMedDRA10047228 C78364 E11737 Injury to jugular vein Injury to superior vena cava 10022356 NCIA finding of damage to the superior vena cava. Injury to inferior vena cava, unspecifiedLLTMedDRA10022214 Injury to inferior vena cavaLLTMedDRA10022213 Injury to superior vena cavaLLTMedDRA10022356 Injury to superior vena cavaPTCTCAE Vena cava injuryLLTMedDRA10047194 C78365 E11741 Injury to superior vena cava Insomnia 10022437 NCIA disorder characterized by difficulty in falling asleep and/or remaining asleep. Chronic insomniaLLTMedDRA10053851 Difficulty sleepingLLTMedDRA10012804 DysphylaxiaLLTMedDRA10063453 Insomnia (non-organic)LLTMedDRA10022438 Insomnia NOSLLTMedDRA10022442 Insomnia exacerbatedLLTMedDRA10022440 InsomniaLLTMedDRA10022437 InsomniaPTCTCAE Primary insomniaLLTMedDRA10036701 Sleep decreasedLLTMedDRA10040982 Sleep difficultLLTMedDRA10040983 Sleep lossLLTMedDRA10041001 SleeplessnessLLTMedDRA10041017 Transient insomniaLLTMedDRA10063467 C28286 E12925 Insomnia Intestinal stoma leak 10059095 NCIA finding of leakage of contents from an intestinal stoma (surgically created opening on the surface of the body). Colostomy malfunctionLLTMedDRA10010047 Colostomy prolapseLLTMedDRA10058044 Continent ileostomy complicationLLTMedDRA10058932 Gastrointestinal stoma complicationLLTMedDRA10065718 Gastrointestinal stoma necrosisLLTMedDRA10065712 Ileostomy malfunctionLLTMedDRA10021324 Ileostomy overactiveLLTMedDRA10021326 Ileostomy underactiveLLTMedDRA10059093 Intestinal stoma complicationLLTMedDRA10059060 Intestinal stoma leakLLTMedDRA10059095 Intestinal stoma leakPTCTCAE Intestinal stoma obstructionLLTMedDRA10059094 Jejunostomy malfunctionLLTMedDRA10052091 Obstructed colostomyLLTMedDRA10059092 Obstructed ileostomyLLTMedDRA10059091 Other complication of colostomy or enterostomyLLTMedDRA10031765 Overactive ileostomyLLTMedDRA10033290 Prolapse of intestinal stomaLLTMedDRA10065745 Stenosis of gastrointestinal stomaLLTMedDRA10065898 Stomal nipple complicationLLTMedDRA10058933 Unspecified complication of colostomy and enterostomyLLTMedDRA10045671 C78369 E11753 Intestinal stoma leak Intestinal stoma obstruction 10059094 NCIA finding of blockage of the normal flow of the contents of the intestinal stoma. Colostomy malfunctionLLTMedDRA10010047 Colostomy prolapseLLTMedDRA10058044 Continent ileostomy complicationLLTMedDRA10058932 Gastrointestinal stoma complicationLLTMedDRA10065718 Gastrointestinal stoma necrosisLLTMedDRA10065712 Ileostomy malfunctionLLTMedDRA10021324 Ileostomy overactiveLLTMedDRA10021326 Ileostomy underactiveLLTMedDRA10059093 Intestinal stoma complicationLLTMedDRA10059060 Intestinal stoma leakLLTMedDRA10059095 Intestinal stoma obstructionLLTMedDRA10059094 Intestinal stoma obstructionPTCTCAE Jejunostomy malfunctionLLTMedDRA10052091 Obstructed colostomyLLTMedDRA10059092 Obstructed ileostomyLLTMedDRA10059091 Other complication of colostomy or enterostomyLLTMedDRA10031765 Overactive ileostomyLLTMedDRA10033290 Prolapse of intestinal stomaLLTMedDRA10065745 Stenosis of gastrointestinal stomaLLTMedDRA10065898 Stomal nipple complicationLLTMedDRA10058933 Unspecified complication of colostomy and enterostomyLLTMedDRA10045671 C78370 E11759 Intestinal stoma obstruction Intestinal stoma site bleeding 10049468 NCIA finding of blood leakage from the intestinal stoma. Bleeding after stem cell transplantationLLTMedDRA10056503 Bleeding of suture siteLLTMedDRA10005125 Bleeding postoperativeLLTMedDRA10005127 Intestinal stoma site bleedingLLTMedDRA10049468 Intestinal stoma site bleedingPTCTCAE Post biopsy bleedingLLTMedDRA10054113 Post procedural bleedingLLTMedDRA10051014 Post procedural haemorrhageLLTMedDRA10051077 Post procedural hemorrhageLLTMedDRA10055320 Postoperative bleedingLLTMedDRA10036277 Postoperative haemorrhageLLTMedDRA10054709 Postoperative hemorrhageLLTMedDRA10055322 Stoma site bleedingLLTMedDRA10059020 Tracheostomy site bleedingLLTMedDRA10065749 Urostomy site bleedingLLTMedDRA10065748 C78371 E11764 Intestinal stoma site bleeding Intra-abdominal hemorrhage 10055291 NCIA disorder characterized by bleeding in the abdominal cavity. Haemorrhage intraabdominalLLTMedDRA10018984 Hemorrhage intraabdominalLLTMedDRA10055268 Intra-abdominal haemorrhage NOSLLTMedDRA10022729 Intra-abdominal haemorrhageLLTMedDRA10061249 Intra-abdominal hemorrhageLLTMedDRA10055291 Intra-abdominal hemorrhagePTCTCAE C78372 E10817 Intra-abdominal hemorrhage Intracranial hemorrhage 10022763 NCIA disorder characterized by bleeding from the cranium. Bleeding intracranialLLTMedDRA10005121 Haemorrhage intracranialLLTMedDRA10018985 Hemorrhage intracranialLLTMedDRA10019552 Intracranial haemorrhage NOSLLTMedDRA10022760 Intracranial haemorrhage, unspecifiedLLTMedDRA10022762 Intracranial hemorrhage, unspecifiedLLTMedDRA10055295 Intracranial hemorrhageLLTMedDRA10022763 Intracranial hemorrhagePTCTCAE Unspecified intracranial haemorrhageLLTMedDRA10045980 Unspecified intracranial hemorrhageLLTMedDRA10045981 C50438 E12696 Intracranial hemorrhage Intraoperative arterial injury 10065826 NCIA finding of damage to an artery during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative arterial injuryPTCTCAE Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78375 E11770 Intraoperative arterial injury Intraoperative breast injury 10065831 NCIA finding of damage to the breast parenchyma during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative breast injuryPTCTCAE Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78376 E11776 Intraoperative breast injury Intraoperative cardiac injury 10065843 NCIA finding of damage to the heart during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative cardiac injuryPTCTCAE Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78377 E11782 Intraoperative cardiac injury Intraoperative ear injury 10065844 NCIA finding of damage to the ear during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative ear injuryPTCTCAE Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78378 E11786 Intraoperative ear injury Intraoperative endocrine injury 10065834 NCIA finding of damage to the endocrine gland during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative endocrine injuryPTCTCAE Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78379 E11792 Intraoperative endocrine injury Intraoperative gastrointestinal injury 10065825 NCIA finding of damage to the gastrointestinal system during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative gastrointestinal injuryPTCTCAE Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78380 E11798 Intraoperative gastrointestinal injury Intraoperative head and neck injury 10065842 NCIA finding of damage to the head and neck during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative head and neck injuryPTCTCAE Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78381 E11804 Intraoperative head and neck injury Intraoperative hemorrhage 10055298 NCIA finding of uncontrolled bleeding during a surgical procedure. Intraoperative bleedingLLTMedDRA10051536 Intraoperative haemorrhageLLTMedDRA10050107 Intraoperative hemorrhageLLTMedDRA10055298 Intraoperative hemorrhagePTCTCAE Operation site bleedLLTMedDRA10030859 Operative haemorrhageLLTMedDRA10030860 Operative hemorrhageLLTMedDRA10055310 C35135 E11810 Intraoperative hemorrhage Intraoperative hepatobiliary injury 10065827 NCIA finding of damage to the hepatic parenchyma and/or biliary tract during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative hepatobiliary injuryPTCTCAE Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78382 E11814 Intraoperative hepatobiliary injury Intraoperative musculoskeletal injury 10065829 NCIA finding of damage to the musculoskeletal system during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative musculoskeletal injuryPTCTCAE Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78383 E11820 Intraoperative musculoskeletal injury Intraoperative neurological injury 10065830 NCIA finding of damage to the nervous system during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative neurological injuryPTCTCAE Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78384 E11826 Intraoperative neurological injury Intraoperative ocular injury 10065841 NCIA finding of damage to the eye during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative ocular injuryPTCTCAE Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78385 E11832 Intraoperative ocular injury Intraoperative renal injury 10065845 NCIA finding of damage to the kidney during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative renal injuryPTCTCAE Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78386 E11838 Intraoperative renal injury Intraoperative reproductive tract injury 10065840 NCIA finding of damage to the reproductive organs during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative reproductive tract injuryPTCTCAE Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78387 E11844 Intraoperative reproductive tract injury Intraoperative respiratory injury 10065832 NCIA finding of damage to the respiratory system during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative respiratory injuryPTCTCAE Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78388 E11850 Intraoperative respiratory injury Intraoperative skin injury 10065846 NCIA finding of damage to the skin during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative skin injuryPTCTCAE Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78389 E11856 Intraoperative skin injury Intraoperative splenic injury 10065847 NCIA finding of damage to the spleen during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative splenic injuryPTCTCAE Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78390 E11862 Intraoperative splenic injury Intraoperative urinary injury 10065828 NCIA finding of damage to the urinary system during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative urinary injuryPTCTCAE Intraoperative venous injuryLLTMedDRA10065848 Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78391 E11867 Intraoperative urinary injury Intraoperative venous injury 10065848 NCIA finding of damage to a vein during a surgical procedure. Intraoperative arterial injuryLLTMedDRA10065826 Intraoperative breast injuryLLTMedDRA10065831 Intraoperative cardiac injuryLLTMedDRA10065843 Intraoperative complicationsLLTMedDRA10052620 Intraoperative ear injuryLLTMedDRA10065844 Intraoperative endocrine injuryLLTMedDRA10065834 Intraoperative gastrointestinal injuryLLTMedDRA10065825 Intraoperative head and neck injuryLLTMedDRA10065842 Intraoperative hepatobiliary injuryLLTMedDRA10065827 Intraoperative injuryLLTMedDRA10065824 Intraoperative musculoskeletal injuryLLTMedDRA10065829 Intraoperative neurological injuryLLTMedDRA10065830 Intraoperative ocular injuryLLTMedDRA10065841 Intraoperative renal injuryLLTMedDRA10065845 Intraoperative reproductive tract injuryLLTMedDRA10065840 Intraoperative respiratory injuryLLTMedDRA10065832 Intraoperative skin injuryLLTMedDRA10065846 Intraoperative splenic injuryLLTMedDRA10065847 Intraoperative urinary injuryLLTMedDRA10065828 Intraoperative venous injuryLLTMedDRA10065848 Intraoperative venous injuryPTCTCAE Procedural complicationLLTMedDRA10057765 Surgery prolongedLLTMedDRA10042610 Therapeutic procedural complicationLLTMedDRA10045682 C78392 E11873 Intraoperative venous injury Investigations 10022891 InvestigationsPTCTCAE E13870 Investigations Investigations - Other, specify Investigations - Other, specifyPTCTCAE E12179 Investigations - Other, specify Iron overload 10065973 NCIA disorder characterized by accumulation of iron in the tissues. Chronic iron overloadLLTMedDRA10065974 Iron overloadLLTMedDRA10065973 Iron overloadPTCTCAE C78393 E12350 Iron overload Irregular menstruation 10022992 NCIA disorder characterized by irregular cycle or duration of menses. Irregular menstruationPTCTCAE C35219 E13125 Irregular menstruation Irritability 10022998 NCIA disorder characterized by an abnormal responsiveness to stimuli or physiological arousal; may be in response to pain, fright, a drug, an emotional situation or a medical condition. ErethismLLTMedDRA10015123 Feeling irritatedLLTMedDRA10016337 IrritabilityLLTMedDRA10022998 IrritabilityPTCTCAE Irritable excitationLLTMedDRA10023006 Irritable sensation transientLLTMedDRA10023008 Irritable symptomLLTMedDRA10023010 IrritableLLTMedDRA10023000 Slightly irritableLLTMedDRA10041022 SnappyLLTMedDRA10041231 C50623 E11144 Irritability Ischemia cerebrovascular 10023030 NCIA disorder characterized by a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage. Anoxia cerebralLLTMedDRA10002661 Cerebral ischaemiaLLTMedDRA10008120 Cerebral ischemiaLLTMedDRA10008121 Chronic cerebral ischaemiaLLTMedDRA10066553 Chronic cerebral ischemiaLLTMedDRA10066552 Ischaemia cerebralLLTMedDRA10055749 Ischaemia cerebrovascularLLTMedDRA10055750 Ischemia cerebralLLTMedDRA10023029 Ischemia cerebrovascularLLTMedDRA10023030 Ischemia cerebrovascularPTCTCAE C78394 E12702 Ischemia cerebrovascular Jejunal fistula 10065719 NCIA disorder characterized by an abnormal communication between the jejunum and another organ or anatomic site. Jejunal fistulaLLTMedDRA10065719 Jejunal fistulaPTCTCAE C78396 E10822 Jejunal fistula Jejunal hemorrhage 10055300 NCIA disorder characterized by bleeding from the jejunal wall. Duodenal bleedingLLTMedDRA10013814 Duodenal haemorrhageLLTMedDRA10013829 Duodenal hemorrhageLLTMedDRA10055242 Haemorrhage duodenumLLTMedDRA10055804 Haemorrhage ileumLLTMedDRA10055812 Haemorrhage jejunumLLTMedDRA10055819 Haemorrhage of ileumLLTMedDRA10055828 Haemorrhage of jejunumLLTMedDRA10055829 Hemorrhage duodenumLLTMedDRA10019534 Hemorrhage ileumLLTMedDRA10019546 Hemorrhage jejunumLLTMedDRA10019556 Hemorrhage of ileumLLTMedDRA10019567 Hemorrhage of jejunumLLTMedDRA10019568 Ileal haemorrhageLLTMedDRA10021301 Ileal hemorrhageLLTMedDRA10055287 Jejunal haemorrhageLLTMedDRA10023173 Jejunal hemorrhageLLTMedDRA10055300 Jejunal hemorrhagePTCTCAE Small intestinal haemorrhageLLTMedDRA10052535 Small intestinal hemorrhageLLTMedDRA10055337 C78397 E10828 Jejunal hemorrhage Jejunal obstruction 10065732 NCIA disorder characterized by blockage of the normal flow of the intestinal contents in the jejunum. Ileal obstructionLLTMedDRA10065730 Jejunal obstructionLLTMedDRA10065732 Jejunal obstructionPTCTCAE Obstruction small intestineLLTMedDRA10029969 Partial small intestinal obstructionLLTMedDRA10056357 Small bowel obstructionLLTMedDRA10041055 Small intestinal obstruction NOSLLTMedDRA10041102 Small intestinal obstructionLLTMedDRA10041101 Small intestine obstructionLLTMedDRA10041129 C78398 E10834 Jejunal obstruction Jejunal perforation 10023174 NCIA disorder characterized by a rupture in the jejunal wall. Jejunal perforationLLTMedDRA10023174 Jejunal perforationPTCTCAE Perforation jejunalLLTMedDRA10034414 C78399 E10840 Jejunal perforation Jejunal stenosis 10023176 NCIA disorder characterized by a narrowing of the lumen of the jejunum. Jejunal stenosisLLTMedDRA10023176 Jejunal stenosisPTCTCAE Stenosis jejunumLLTMedDRA10041981 Stenosis of jejunumLLTMedDRA10041985 C78400 E10845 Jejunal stenosis Jejunal ulcer 10023177 NCIA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the jejunum. Jejunal ulcerLLTMedDRA10023177 Jejunal ulcerPTCTCAE Ulcer jejunumLLTMedDRA10045314 Ulcer of jejunumLLTMedDRA10045325 C78401 E10851 Jejunal ulcer Joint effusion 10023215 NCIA disorder characterized by excessive fluid in a joint, usually as a result of joint inflammation. Ankle effusionLLTMedDRA10002543 Effusion (l) kneeLLTMedDRA10014294 Effusion (r) kneeLLTMedDRA10014295 Effusion of ankleLLTMedDRA10014296 Effusion of elbowLLTMedDRA10014298 Effusion of forearm jointLLTMedDRA10014299 Effusion of hand jointLLTMedDRA10014300 Effusion of joint of shoulder regionLLTMedDRA10014305 Effusion of joint, site unspecifiedLLTMedDRA10014306 Effusion of jointLLTMedDRA10014301 Effusion of kneeLLTMedDRA10014307 Effusion of lower leg jointLLTMedDRA10014308 Effusion of upper arm jointLLTMedDRA10014309 Effusion of wristLLTMedDRA10014310 Elbow effusionLLTMedDRA10014343 HydrarthrosisLLTMedDRA10020487 Joint effusion aggravatedLLTMedDRA10048314 Joint effusionLLTMedDRA10023215 Joint effusionPTCTCAE Knee effusionLLTMedDRA10023474 Wrist effusionLLTMedDRA10048048 C49052 E12431 Joint effusion Joint infection 10023216 NCIA disorder characterized by an infectious process involving a joint. Arthritis infective NOSLLTMedDRA10003259 Arthritis infectiveLLTMedDRA10060968 Infective arthritis NOSLLTMedDRA10021915 Joint infectionLLTMedDRA10023216 Joint infectionPTCTCAE Post dysenteric arthropathyLLTMedDRA10057231 Sternoarticular pyarthrosisLLTMedDRA10042017 Unspecified infective arthritis involving forearmLLTMedDRA10045950 Unspecified infective arthritis involving handLLTMedDRA10045951 Unspecified infective arthritis involving lower legLLTMedDRA10045952 Unspecified infective arthritis involving shoulder regionLLTMedDRA10045956 Unspecified infective arthritis involving upper armLLTMedDRA10045957 Unspecified infective arthritis, site unspecifiedLLTMedDRA10045958 Unspecified infective arthritisLLTMedDRA10045948 C78402 E11426 Joint infection Joint range of motion decreased 10048706 NCIA disorder characterized by a decrease in joint flexibility of any joint. Joint range of motion decreased cervical spineLLTMedDRA10065796 Joint range of motion decreased lumbar spineLLTMedDRA10065800 Joint range of motion decreasedLLTMedDRA10048706 Joint range of motion decreasedPTCTCAE C78403 E12435 Joint range of motion decreased Joint range of motion decreased cervical spine 10065796 NCIA disorder characterized by a decrease in flexibility of a cervical spine joint. Joint range of motion decreased cervical spineLLTMedDRA10065796 Joint range of motion decreased cervical spinePTCTCAE Joint range of motion decreased lumbar spineLLTMedDRA10065800 Joint range of motion decreasedLLTMedDRA10048706 C78404 E12439 Joint range of motion decreased cervical spine Joint range of motion decreased lumbar spine 10065800 NCIA disorder characterized by a decrease in flexibility of a lumbar spine joint. Joint range of motion decreased cervical spineLLTMedDRA10065796 Joint range of motion decreased lumbar spineLLTMedDRA10065800 Joint range of motion decreased lumbar spinePTCTCAE Joint range of motion decreasedLLTMedDRA10048706 C78405 E12443 Joint range of motion decreased lumbar spine Keratitis 10023332 NCIA disorder characterized by inflammation to the cornea of the eye. Corneal inflammationLLTMedDRA10011023 Corneal irritationLLTMedDRA10056476 DescemetitisLLTMedDRA10051241 Exposure keratoconjunctivitisLLTMedDRA10015706 Filamentary keratitisLLTMedDRA10016672 Inflammation cornealLLTMedDRA10021953 Keratitis NOSLLTMedDRA10023336 Keratitis striateLLTMedDRA10023340 Keratitis superficialLLTMedDRA10023341 Keratitis vascularLLTMedDRA10023343 Keratitis vesicularLLTMedDRA10023344 Keratitis, unspecifiedLLTMedDRA10023346 KeratitisLLTMedDRA10023332 KeratitisPTCTCAE Keratoconjunctivitis, unspecifiedLLTMedDRA10023352 KeratoconjunctivitisLLTMedDRA10023348 Macular keratitisLLTMedDRA10025413 Marginal keratitisLLTMedDRA10026830 Neurotrophic keratoconjunctivitisLLTMedDRA10029353 Phlyctenular keratoconjunctivitisLLTMedDRA10034910 SclerokeratitisLLTMedDRA10064846 Superficial keratitis, unspecifiedLLTMedDRA10042542 Unspecified keratitisLLTMedDRA10045988 C26805 E10397 Keratitis Kidney anastomotic leak 10065803 NCIA finding of leakage of urine due to breakdown of a kidney anastomosis (surgical connection of two separate anatomic structures). Bladder anastomotic leakLLTMedDRA10065802 Kidney anastomotic leakLLTMedDRA10065803 Kidney anastomotic leakPTCTCAE Ureteric anastomotic leakLLTMedDRA10065814 Urethral anastomotic leakLLTMedDRA10065815 Urinary anastomotic leakLLTMedDRA10060775 C78406 E11879 Kidney anastomotic leak Kidney infection 10023424 NCIA disorder characterized by an infectious process involving the kidney. Acute kidney infectionLLTMedDRA10000822 Chronic kidney infectionLLTMedDRA10008939 Infection of kidney, unspecifiedLLTMedDRA10021851 Infection of kidneyLLTMedDRA10021850 Kidney infection NOSLLTMedDRA10023429 Kidney infection acute NOSLLTMedDRA10023426 Kidney infection acuteLLTMedDRA10023425 Kidney infection chronic NOSLLTMedDRA10023428 Kidney infection chronicLLTMedDRA10023427 Kidney infectionLLTMedDRA10023424 Kidney infectionPTCTCAE C34965 E11431 Kidney infection Kyphosis 10023509 NCIA disorder characterized by an abnormal increase in the curvature of the thoracic portion of the spine. Adolescent postural kyphosisLLTMedDRA10001320 Hunchback (acquired)LLTMedDRA10020465 Kyphosis (acquired) (postural)LLTMedDRA10023511 Kyphosis (acquired)LLTMedDRA10023510 KyphosisLLTMedDRA10023509 KyphosisPTCTCAE C34754 E12447 Kyphosis Lactation disorder 10061261 NCIA disorder characterized by disturbances of milk secretion. It is not necessarily related to pregnancy that is observed in females and can be observed in males. Breast feeding problem (maternal)LLTMedDRA10049503 Lactation disorder NOSLLTMedDRA10023664 Lactation disorderLLTMedDRA10061261 Lactation disorderPTCTCAE Unspecified disorder of lactationLLTMedDRA10045801 C79606 E13129 Lactation disorder Large intestinal anastomotic leak 10065891 NCIA finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the large intestine. Esophageal anastomotic leakLLTMedDRA10065961 Gastric anastomotic leakLLTMedDRA10065893 Gastrointestinal anastomotic leakLLTMedDRA10065879 Intestinal anastomotic leakLLTMedDRA10054119 Large intestinal anastomotic leakLLTMedDRA10065891 Large intestinal anastomotic leakPTCTCAE Oesophageal anastomotic leakLLTMedDRA10065890 Rectal anastomotic leakLLTMedDRA10065894 Small intestinal anastomotic leakLLTMedDRA10065892 C78408 E11885 Large intestinal anastomotic leak Laryngeal edema 10023838 NCIA disorder characterized by swelling due to an excessive accumulation of fluid in the larynx. Acute laryngeal edemaLLTMedDRA10066705 Acute laryngeal oedemaLLTMedDRA10066706 Aryepiglottis edemaLLTMedDRA10057853 Aryepiglottis oedemaLLTMedDRA10057859 Edema glottisLLTMedDRA10014225 Edema larynxLLTMedDRA10014229 Edema of larynxLLTMedDRA10014238 Edema vocal cordLLTMedDRA10014261 Glottic edemaLLTMedDRA10018392 Glottic oedemaLLTMedDRA10018393 Laryngeal edemaLLTMedDRA10023838 Laryngeal edemaPTCTCAE Laryngeal oedemaLLTMedDRA10023845 Larynx edemaLLTMedDRA10023912 Larynx oedemaLLTMedDRA10023921 Oedema glottisLLTMedDRA10055921 Oedema larynxLLTMedDRA10055927 Oedema of larynxLLTMedDRA10030116 Oedema vocal cordLLTMedDRA10055941 Subglottic edemaLLTMedDRA10042393 Subglottic oedemaLLTMedDRA10042394 Vocal cord edemaLLTMedDRA10047672 Vocal cord oedemaLLTMedDRA10047673 C79607 E13393 Laryngeal edema Laryngeal fistula 10065786 NCIA disorder characterized by an abnormal communication between the larynx and another organ or anatomic site. Laryngeal fistulaLLTMedDRA10065786 Laryngeal fistulaPTCTCAE C78410 E13399 Laryngeal fistula Laryngeal hemorrhage 10065759 NCIA disorder characterized by bleeding from the larynx. Laryngeal haemorrhageLLTMedDRA10065740 Laryngeal hemorrhageLLTMedDRA10065759 Laryngeal hemorrhagePTCTCAE C78411 E13405 Laryngeal hemorrhage Laryngeal inflammation 10065735 NCIA disorder characterized by an inflammation involving the larynx. Laryngeal inflammationLLTMedDRA10065735 Laryngeal inflammationPTCTCAE Laryngeal mucositisLLTMedDRA10065880 C26811 E13411 Laryngeal inflammation Laryngeal mucositis 10065880 NCIA disorder characterized by an inflammation involving the mucous membrane of the larynx. Laryngeal inflammationLLTMedDRA10065735 Laryngeal mucositisLLTMedDRA10065880 Laryngeal mucositisPTCTCAE C78412 E13415 Laryngeal mucositis Laryngeal obstruction 10059639 NCIA disorder characterized by blockage of the laryngeal airway. Laryngeal obstructionLLTMedDRA10059639 Laryngeal obstructionPTCTCAE Subglottic obstructionLLTMedDRA10065251 C78413 E13421 Laryngeal obstruction Laryngeal stenosis 10023862 NCIA disorder characterized by a narrowing of the laryngeal airway. Laryngeal stenosisLLTMedDRA10023862 Laryngeal stenosisPTCTCAE Laryngeal strictureLLTMedDRA10023863 Stenosis of larynxLLTMedDRA10041989 Subglottic stenosisLLTMedDRA10042395 Supraglottic stenosisLLTMedDRA10059408 C79608 E13427 Laryngeal stenosis Laryngitis 10023874 NCIA disorder characterized by an inflammatory process involving the larynx. Acute laryngitisLLTMedDRA10000823 Chronic laryngitisLLTMedDRA10008940 Laryngitis (acute)LLTMedDRA10023875 Laryngitis NOSLLTMedDRA10023879 Laryngitis acute NOSLLTMedDRA10023876 Laryngitis chronic NOSLLTMedDRA10023878 Laryngitis chronicLLTMedDRA10023877 LaryngitisLLTMedDRA10023874 LaryngitisPTCTCAE C26811 E11435 Laryngitis Laryngopharyngeal dysesthesia 10062667 NCIA disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx. Dysaesthesia pharynxLLTMedDRA10062665 Dysesthesia pharynxLLTMedDRA10062666 Laryngopharyngeal dysaesthesiaLLTMedDRA10062668 Laryngopharyngeal dysesthesiaLLTMedDRA10062667 Laryngopharyngeal dysesthesiaPTCTCAE C78414 E13433 Laryngopharyngeal dysesthesia Laryngospasm 10023891 NCIA disorder characterized by paroxysmal spasmodic muscular contraction of the vocal cords. Glottic spasmLLTMedDRA10018394 Laryngeal spasmLLTMedDRA10023854 LaryngismusLLTMedDRA10023873 LaryngospasmLLTMedDRA10023891 LaryngospasmPTCTCAE Larynx muscle hypersensitiveLLTMedDRA10023913 Spasm glottisLLTMedDRA10041387 Spasm larynxLLTMedDRA10041389 C79609 E13439 Laryngospasm Left ventricular systolic dysfunction NCIA disorder characterized by failure of the left ventricle to produce adequate output despite an increase in distending pressure and in end-diastolic volume. Clinical manifestations mayinclude dyspnea, orthopnea, and other signs and symptoms of pulmonary congestion and edema. Left ventricular systolic dysfunctionPTCTCAE C64251 E10130 Left ventricular systolic dysfunction Lethargy 10024264 NCIA disorder characterized by a decrease in consciousness characterized by mental and physical inertness. Lethargic tendencyLLTMedDRA10024263 LethargicLLTMedDRA10024262 LethargyLLTMedDRA10024264 LethargyPTCTCAE C78416 E12709 Lethargy Leukemia secondary to oncology chemotherapy 10048293 NCIA disorder characterized by leukemia arising as a result of the mutagenic effect of chemotherapy agents. Leukemia secondary to oncology chemotherapyPTCTCAE C80691 E12549 Leukemia secondary to oncology chemotherapy Leukocytosis 10024378 NCIA disorder characterized by laboratory test results that indicate an increased number of white blood cells in the blood. Leucocytosis NOSLLTMedDRA10024279 LeukocytosisLLTMedDRA10024378 LeukocytosisPTCTCAE Polymorphonuclear leucocytosisLLTMedDRA10036096 Polymorphonuclear leukocytosisLLTMedDRA10055658 C35524 E10048 Leukocytosis Leukoencephalopathy 10024382 NCIA disorder characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation. Disseminated necrotising leukoencephalopathyLLTMedDRA10067611 Disseminated necrotizing leukoencephalopathyLLTMedDRA10067605 LeukoencephalopathyLLTMedDRA10024382 LeukoencephalopathyPTCTCAE C27059 E12712 Leukoencephalopathy Libido decreased 10024419 NCIA disorder characterized by a decrease in sexual desire. Hypoactive sexual desire disorderLLTMedDRA10020933 HyposexualityLLTMedDRA10067561 Libido decreasedLLTMedDRA10024419 Libido decreasedPTCTCAE Sexual desire decreasedLLTMedDRA10059272 Sexual feeling decreasedLLTMedDRA10040481 C78432 E12929 Libido decreased Libido increased 10024421 NCIA disorder characterized by an increase in sexual desire. Increased libidoLLTMedDRA10021669 Libido increasedLLTMedDRA10024421 Libido increasedPTCTCAE Sexual desire increasedLLTMedDRA10040471 C78433 E12932 Libido increased Lip infection 10065755 NCIA disorder characterized by an infectious process involving the lips. Infected lipLLTMedDRA10021778 Lip infectionLLTMedDRA10065755 Lip infectionPTCTCAE Oral infectionLLTMedDRA10048685 Superinfection oralLLTMedDRA10048993 C78434 E11440 Lip infection Lip pain 10024561 NCIA disorder characterized by a sensation of marked discomfort of the lip. Lip painLLTMedDRA10024561 Lip painPTCTCAE Lip soreLLTMedDRA10024568 Lip sorenessLLTMedDRA10024569 Sensitive lipsLLTMedDRA10049360 Stinging lipsLLTMedDRA10049359 Tender lipsLLTMedDRA10049358 C79684 E10857 Lip pain Lipase increased 10024574 NCIA finding based on laboratory test results that indicate an increase in the level of lipase in a biological specimen. Lipase increasedLLTMedDRA10024574 Lipase increasedPTCTCAE C78435 E12185 Lipase increased Lipohypertrophy 10062315 NCIA disorder characterized by hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin. Buffalo humpLLTMedDRA10006539 LipohypertrophyLLTMedDRA10062315 LipohypertrophyPTCTCAE C78436 E13657 Lipohypertrophy Localized edema 10062466 NCIA disorder characterized by swelling due to excessive fluid accumulation at a specific anatomic site. Edema abdomenLLTMedDRA10054486 Edema auricularLLTMedDRA10054488 Edema trunkLLTMedDRA10058720 Localised oedemaLLTMedDRA10048961 Localized edemaLLTMedDRA10062466 Localized edemaPTCTCAE Lumbar cushionLLTMedDRA10024990 Neck edema ofLLTMedDRA10055407 Neck edemaLLTMedDRA10054482 Neck oedema ofLLTMedDRA10028835 Neck oedemaLLTMedDRA10028834 Oedema abdomenLLTMedDRA10048651 Oedema auricularLLTMedDRA10030097 Oedema trunkLLTMedDRA10058691 Sacral edemaLLTMedDRA10039349 Sacral oedemaLLTMedDRA10039350 C78437 E11148 Localized edema Lordosis 10024842 NCIA disorder characterized by an abnormal increase in the curvature of the lumbar portion of the spine. Lordosis (acquired) (postural)LLTMedDRA10024844 Lordosis (acquired)LLTMedDRA10024843 LordosisLLTMedDRA10024842 LordosisPTCTCAE C34787 E12451 Lordosis Lower gastrointestinal hemorrhage 10051746 NCIA disorder characterized by bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus). Lower gastrointestinal haemorrhageLLTMedDRA10050953 Lower gastrointestinal hemorrhageLLTMedDRA10051746 Lower gastrointestinal hemorrhagePTCTCAE C78438 E10861 Lower gastrointestinal hemorrhage Lung infection 10061229 NCIA disorder characterized by an infectious process involving the lungs. Lung infection NOSLLTMedDRA10048847 Lung infectionLLTMedDRA10061229 Lung infectionPTCTCAE Pulmonary suppurationLLTMedDRA10049603 Superinfection lungLLTMedDRA10048859 C26873 E11444 Lung infection Lymph gland infection 10050823 NCIA disorder characterized by an infectious process involving the lymph nodes. Lymph gland infectionLLTMedDRA10050823 Lymph gland infectionPTCTCAE C26821 E11449 Lymph gland infection Lymph leakage 10065773 NCIA disorder characterized by the loss of lymph fluid into the surrounding tissue or body cavity. Lymph leakageLLTMedDRA10065773 Lymph leakagePTCTCAE LymphorrheaLLTMedDRA10058831 LymphorrhoeaLLTMedDRA10050979 C78439 E13797 Lymph leakage Lymph node pain 10025182 NCIA disorder characterized by a sensation of marked discomfort in a lymph node. Lymph node painLLTMedDRA10025182 Lymph node painPTCTCAE Lymph node tendernessLLTMedDRA10065018 C78440 E10052 Lymph node pain Lymphedema 10025233 NCIA disorder characterized by excessive fluid collection in tissues that causes swelling. Localised accumulation of lymphatic fluidLLTMedDRA10049715 Localized accumulation of lymphatic fluidLLTMedDRA10062465 Lymphedema praecoxLLTMedDRA10054461 LymphedemaLLTMedDRA10025233 LymphedemaPTCTCAE Lymphoedema NOSLLTMedDRA10025284 Lymphoedema praecoxLLTMedDRA10025285 LymphoedemaLLTMedDRA10025282 C3207 E13802 Lymphedema Lymphocele 10048642 NCIA disorder characterized by a cystic lesion containing lymph. Lymphatic cystLLTMedDRA10052356 LymphoceleLLTMedDRA10048642 LymphocelePTCTCAE C78442 E13806 Lymphocele Lymphocyte count decreased 10025256 NCIA finding based on laboratory test results that indicate a decrease in number of lymphocytes in a blood specimen. Lymphocyte count decreasedPTCTCAE C26823 E12190 Lymphocyte count decreased Lymphocyte count increased 10025258 NCIA finding based on laboratory test results that indicate an abnormal increase in the number of lymphocytes in the blood, effusions or bone marrow. Lymphocyte count increasedPTCTCAE C34791 E12195 Lymphocyte count increased Malabsorption 10025476 NCIA disorder characterized by inadequate absorption of nutrients in the small intestine. Symptoms include abdominal marked discomfort, bloating and diarrhea. Intestinal malabsorptionLLTMedDRA10022683 Malabsorption syndromeLLTMedDRA10025479 MalabsorptionLLTMedDRA10025476 MalabsorptionPTCTCAE Sprue NOSLLTMedDRA10041800 SprueLLTMedDRA10041799 Syndrome malabsorptionLLTMedDRA10042822 Syndrome sprue-likeLLTMedDRA10042847 Unspecified intestinal malabsorptionLLTMedDRA10045978 C3214 E10867 Malabsorption Malaise 10025482 NCIA disorder characterized by a feeling of general discomfort or uneasiness, an out-of-sorts feeling. Feeling sickLLTMedDRA10016365 Feeling unwellLLTMedDRA10016370 Felt generally illLLTMedDRA10016380 Felt illLLTMedDRA10016383 General malaiseLLTMedDRA10018066 Generalised illnessLLTMedDRA10018084 Generalized illnessLLTMedDRA10062436 Generally unwellLLTMedDRA10018135 Ill feelingLLTMedDRA10021345 MalaiseLLTMedDRA10025482 MalaisePTCTCAE SicknessLLTMedDRA10040658 UnwellLLTMedDRA10046268 C3832 E11152 Malaise Mania 10026749 NCIA disorder characterized by excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganization of behavior and elevation of mood. Acute maniaLLTMedDRA10000852 Atypical manic disorderLLTMedDRA10003752 Change to manic stateLLTMedDRA10008400 Mania acuteLLTMedDRA10026750 Mania aggravatedLLTMedDRA10026751 ManiaLLTMedDRA10026749 ManiaPTCTCAE Manic disorder, recurrent episode, in full remissionLLTMedDRA10026760 Manic disorder, recurrent episodeLLTMedDRA10026759 Manic disorder, single episode, in full remissionLLTMedDRA10026770 Manic disorder, single episodeLLTMedDRA10026769 Manic episodeLLTMedDRA10026778 Manic excitementLLTMedDRA10026779 Manic psychosisLLTMedDRA10026780 Manic reactionLLTMedDRA10026781 Manic state aggravatedLLTMedDRA10026783 Manic stateLLTMedDRA10026782 ManicLLTMedDRA10026752 Psychosis manicLLTMedDRA10037239 Reaction manicLLTMedDRA10037953 C61374 E12936 Mania Mediastinal hemorrhage 10056356 NCIA disorder characterized by bleeding from the mediastinum. Mediastinal haemorrhageLLTMedDRA10056343 Mediastinal hemorrhageLLTMedDRA10056356 Mediastinal hemorrhagePTCTCAE C78443 E13444 Mediastinal hemorrhage Mediastinal infection 10057483 NCIA disorder characterized by an infectious process involving the mediastinum. Mediastinal infectionLLTMedDRA10057483 Mediastinal infectionPTCTCAE MediastinitisLLTMedDRA10027082 Retrosternal infectionLLTMedDRA10056516 C26827 E11454 Mediastinal infection Memory impairment 10027175 NCIA disorder characterized by a deterioration in memory function. ForgetfulnessLLTMedDRA10017060 HypomnesiaLLTMedDRA10021035 Memory deficitLLTMedDRA10027171 Memory disturbance (excl dementia)LLTMedDRA10027173 Memory disturbanceLLTMedDRA10027172 Memory impairedLLTMedDRA10027174 Memory impairmentLLTMedDRA10027175 Memory impairmentPTCTCAE Short-term memory impairmentLLTMedDRA10068446 C78444 E12718 Memory impairment Meningismus 10027198 NCIA disorder characterized by neck stiffness, headache, and photophobia resulting from irritation of the cerebral meninges. Meningeal irritationLLTMedDRA10027188 MeningismLLTMedDRA10027197 MeningismusLLTMedDRA10027198 MeningismusPTCTCAE Meningitis-like reactionLLTMedDRA10027265 Meningitis-likeLLTMedDRA10027264 C79694 E12722 Meningismus Meningitis 10027199 NCIA disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord. MeningitisPTCTCAE C26828 E11458 Meningitis Menopause 10027308 NCIA disorder characterized by the permanent cessation of menses, usually defined by 12 consecutive months of amenorrhea in a woman over 45 years of age. ClimactericLLTMedDRA10009285 MenopausalLLTMedDRA10027296 MenopauseLLTMedDRA10027308 MenopausePTCTCAE Natural menopauseLLTMedDRA10028812 PerimenopauseLLTMedDRA10062974 PremenopauseLLTMedDRA10051826 C3231 E13750 Menopause Menorrhagia 10027313 NCIA disorder characterized by abnormally heavy vaginal bleeding during menses. Bleeding menstrual heavyLLTMedDRA10005123 Excessive menstruationLLTMedDRA10015606 Heavy periodsLLTMedDRA10019360 HypermenorrheaLLTMedDRA10020672 HypermenorrhoeaLLTMedDRA10020673 Menopausal menorrhagiaLLTMedDRA10027302 MenorrhagiaLLTMedDRA10027313 MenorrhagiaPTCTCAE MenostaxisLLTMedDRA10067344 Menses regular with excessive bleedingLLTMedDRA10027322 Menstrual floodingLLTMedDRA10027330 Menstrual flow excessiveLLTMedDRA10027332 Menstruation increasedLLTMedDRA10027338 Menstruation prolongedLLTMedDRA10027340 Pre-menopausal menorrhagiaLLTMedDRA10036501 Premenopausal menorrhagiaLLTMedDRA10036617 Prolonged heavy periodsLLTMedDRA10036867 Prolonged mensesLLTMedDRA10036874 Prolonged periodsLLTMedDRA10036875 Pubertal menorrhagiaLLTMedDRA10037279 C26829 E13132 Menorrhagia Metabolism and nutrition disorders 10027433 Metabolism and nutrition disordersPTCTCAE E13858 Metabolism and nutrition disorders Metabolism and nutrition disorders - Other, specify Metabolism and nutrition disorders - Other, specifyPTCTCAE E12355 Metabolism and nutrition disorders - Other, specify Middle ear inflammation 10065838 NCIA disorder characterized by inflammation (physiologic response to irritation), swelling and redness to the middle ear. Middle ear inflammationLLTMedDRA10065838 Middle ear inflammationPTCTCAE C34885 E10281 Middle ear inflammation Mitral valve disease 10061532 NCIA disorder characterized by a defect in mitral valve function or structure. Diseases of mitral valveLLTMedDRA10013126 Mitral valve disease NOSLLTMedDRA10027725 Mitral valve diseaseLLTMedDRA10061532 Mitral valve diseasePTCTCAE Other and unspecified mitral valve diseasesLLTMedDRA10031604 C78446 E10134 Mitral valve disease Mobitz type I 10027787 NCIA disorder characterized by a dysrhythmia with a progressively lengthening PR interval prior to the blocking of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles. 2nd degree heart blockLLTMedDRA10000022 AV block second degreeLLTMedDRA10003851 Atrioventricular block second degreeLLTMedDRA10003677 Heart block AV second degreeLLTMedDRA10019259 Heart block second degreeLLTMedDRA10019268 High grade atrioventricular blockLLTMedDRA10068670 Mobitz (type) II atrioventricular blockLLTMedDRA10027786 Mobitz type ILLTMedDRA10027787 Mobitz type IPTCTCAE Mobitz type IILLTMedDRA10027788 Type I second degree atrioventricular blockLLTMedDRA10050797 Type II second degree atrioventricular blockLLTMedDRA10050798 Wenckebach phenomenonLLTMedDRA10047909 WenckebachLLTMedDRA10047908 C62017 E10146 Mobitz type I Mobitz (type) II atrioventricular block 10027786 NCIA disorder characterized by a dysrhythmia with relatively constant PR interval prior to the block of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles. 2nd degree heart blockLLTMedDRA10000022 AV block second degreeLLTMedDRA10003851 Atrioventricular block second degreeLLTMedDRA10003677 Heart block AV second degreeLLTMedDRA10019259 Heart block second degreeLLTMedDRA10019268 High grade atrioventricular blockLLTMedDRA10068670 Mobitz (type) II atrioventricular blockLLTMedDRA10027786 Mobitz (type) II atrioventricular blockPTCTCAE Mobitz type ILLTMedDRA10027787 Mobitz type IILLTMedDRA10027788 Type I second degree atrioventricular blockLLTMedDRA10050797 Type II second degree atrioventricular blockLLTMedDRA10050798 Wenckebach phenomenonLLTMedDRA10047909 WenckebachLLTMedDRA10047908 C62018 E10140 Mobitz (type) II atrioventricular block Movements involuntary 10028041 NCIA disorder characterized by uncontrolled and purposeless movements. Abnormal involuntary movementsLLTMedDRA10000151 Acute dyskinesiaLLTMedDRA10000727 Body movements involuntaryLLTMedDRA10005899 Dyskinesia acuteLLTMedDRA10013917 Dyskinesia aggravatedLLTMedDRA10013918 Dyskinesia buccoglossalLLTMedDRA10013919 Dyskinesia circumoralLLTMedDRA10013920 Dyskinesia syndromeLLTMedDRA10013927 DyskinesiaLLTMedDRA10013916 Dyskinetic syndromeLLTMedDRA10013930 Head-face-neck syndromeLLTMedDRA10019209 Head-face-neck-syndromeLLTMedDRA10019210 Involuntary movement (NOS)LLTMedDRA10022895 Involuntary movement oral (circumoral)LLTMedDRA10022897 Involuntary movement oralLLTMedDRA10022896 Involuntary muscle movementLLTMedDRA10022898 JerkinessLLTMedDRA10023188 Jerky movement NOSLLTMedDRA10023189 Mouth movement impairedLLTMedDRA10028027 Movements abnormalLLTMedDRA10028039 Movements involuntary of limbsLLTMedDRA10028043 Movements involuntary of muscleLLTMedDRA10028044 Movements involuntaryLLTMedDRA10028041 Movements involuntaryPTCTCAE Movements spastic involuntaryLLTMedDRA10028046 Muscle movement involuntaryLLTMedDRA10028319 Oral dyskinesiaLLTMedDRA10030976 Orofacial dyskinesiaLLTMedDRA10031094 Syndrome dyskineticLLTMedDRA10042802 Syndrome head-face-neckLLTMedDRA10042813 Tongue protrusion spastic involuntaryLLTMedDRA10043974 C78453 E12728 Movements involuntary Mucosal infection 10065764 NCIA disorder characterized by an infectious process involving a mucosal surface. Mucosal infectionLLTMedDRA10065764 Mucosal infectionPTCTCAE C78454 E11462 Mucosal infection Mucositis oral 10028130 NCIA disorder characterized by inflammation of the oral mucosal. Mucositis oralPTCTCAE C26887 E10872 Mucositis oral Multi-organ failure 10028154 NCIA disorder characterized by progressive deterioration of the lungs, liver, kidney and clotting mechanisms. Multi organ failureLLTMedDRA10028151 Multi-organ failureLLTMedDRA10028154 Multi-organ failurePTCTCAE Multiorgan failureLLTMedDRA10028162 Multiple organ failureLLTMedDRA10028237 C75568 E11155 Multi-organ failure Muscle weakness left-sided 10065780 NCIA disorder characterized by a reduction in the strength of the muscles on the left side of the body. Generalised muscle weaknessLLTMedDRA10062571 Generalized muscle weaknessLLTMedDRA10062572 Hands weakness ofLLTMedDRA10019132 Localised muscle weaknessLLTMedDRA10059002 Localized muscle weaknessLLTMedDRA10059003 Lower extremities weakness ofLLTMedDRA10024947 Muscle weakness NOSLLTMedDRA10028351 Muscle weakness aggravatedLLTMedDRA10048391 Muscle weakness left-sidedLLTMedDRA10065780 Muscle weakness left-sidedPTCTCAE Muscle weakness lower limbLLTMedDRA10065776 Muscle weakness right-sidedLLTMedDRA10065794 Muscle weakness trunkLLTMedDRA10065795 Muscle weakness upper limbLLTMedDRA10065895 Muscle weaknessLLTMedDRA10028350 Muscular weaknessLLTMedDRA10028372 MyastheniaLLTMedDRA10028415 Neuromuscular weaknessLLTMedDRA10062976 Weakness in extremityLLTMedDRA10065702 Weakness muscleLLTMedDRA10047867 Weakness of armsLLTMedDRA10050379 Weakness of limbsLLTMedDRA10047868 Weakness voluntary muscleLLTMedDRA10047870 C78455 E12455 Muscle weakness left-sided Muscle weakness lower limb 10065776 NCIA disorder characterized by a reduction in the strength of the lower limb muscles. Generalised muscle weaknessLLTMedDRA10062571 Generalized muscle weaknessLLTMedDRA10062572 Hands weakness ofLLTMedDRA10019132 Localised muscle weaknessLLTMedDRA10059002 Localized muscle weaknessLLTMedDRA10059003 Lower extremities weakness ofLLTMedDRA10024947 Muscle weakness NOSLLTMedDRA10028351 Muscle weakness aggravatedLLTMedDRA10048391 Muscle weakness left-sidedLLTMedDRA10065780 Muscle weakness lower limbLLTMedDRA10065776 Muscle weakness lower limbPTCTCAE Muscle weakness right-sidedLLTMedDRA10065794 Muscle weakness trunkLLTMedDRA10065795 Muscle weakness upper limbLLTMedDRA10065895 Muscle weaknessLLTMedDRA10028350 Muscular weaknessLLTMedDRA10028372 MyastheniaLLTMedDRA10028415 Neuromuscular weaknessLLTMedDRA10062976 Weakness in extremityLLTMedDRA10065702 Weakness muscleLLTMedDRA10047867 Weakness of armsLLTMedDRA10050379 Weakness of limbsLLTMedDRA10047868 Weakness voluntary muscleLLTMedDRA10047870 C78456 E12459 Muscle weakness lower limb Muscle weakness right-sided 10065794 NCIA disorder characterized by a reduction in the strength of the muscles on the right side of the body. Generalised muscle weaknessLLTMedDRA10062571 Generalized muscle weaknessLLTMedDRA10062572 Hands weakness ofLLTMedDRA10019132 Localised muscle weaknessLLTMedDRA10059002 Localized muscle weaknessLLTMedDRA10059003 Lower extremities weakness ofLLTMedDRA10024947 Muscle weakness NOSLLTMedDRA10028351 Muscle weakness aggravatedLLTMedDRA10048391 Muscle weakness left-sidedLLTMedDRA10065780 Muscle weakness lower limbLLTMedDRA10065776 Muscle weakness right-sidedLLTMedDRA10065794 Muscle weakness right-sidedPTCTCAE Muscle weakness trunkLLTMedDRA10065795 Muscle weakness upper limbLLTMedDRA10065895 Muscle weaknessLLTMedDRA10028350 Muscular weaknessLLTMedDRA10028372 MyastheniaLLTMedDRA10028415 Neuromuscular weaknessLLTMedDRA10062976 Weakness in extremityLLTMedDRA10065702 Weakness muscleLLTMedDRA10047867 Weakness of armsLLTMedDRA10050379 Weakness of limbsLLTMedDRA10047868 Weakness voluntary muscleLLTMedDRA10047870 C78457 E12463 Muscle weakness right-sided Muscle weakness trunk 10065795 NCIA disorder characterized by a reduction in the strength of the trunk muscles. Generalised muscle weaknessLLTMedDRA10062571 Generalized muscle weaknessLLTMedDRA10062572 Hands weakness ofLLTMedDRA10019132 Localised muscle weaknessLLTMedDRA10059002 Localized muscle weaknessLLTMedDRA10059003 Lower extremities weakness ofLLTMedDRA10024947 Muscle weakness NOSLLTMedDRA10028351 Muscle weakness aggravatedLLTMedDRA10048391 Muscle weakness left-sidedLLTMedDRA10065780 Muscle weakness lower limbLLTMedDRA10065776 Muscle weakness right-sidedLLTMedDRA10065794 Muscle weakness trunkLLTMedDRA10065795 Muscle weakness trunkPTCTCAE Muscle weakness upper limbLLTMedDRA10065895 Muscle weaknessLLTMedDRA10028350 Muscular weaknessLLTMedDRA10028372 MyastheniaLLTMedDRA10028415 Neuromuscular weaknessLLTMedDRA10062976 Weakness in extremityLLTMedDRA10065702 Weakness muscleLLTMedDRA10047867 Weakness of armsLLTMedDRA10050379 Weakness of limbsLLTMedDRA10047868 Weakness voluntary muscleLLTMedDRA10047870 C78458 E12467 Muscle weakness trunk Muscle weakness upper limb 10065895 NCIA disorder characterized by a reduction in the strength of the upper limb muscles. Generalised muscle weaknessLLTMedDRA10062571 Generalized muscle weaknessLLTMedDRA10062572 Hands weakness ofLLTMedDRA10019132 Localised muscle weaknessLLTMedDRA10059002 Localized muscle weaknessLLTMedDRA10059003 Lower extremities weakness ofLLTMedDRA10024947 Muscle weakness NOSLLTMedDRA10028351 Muscle weakness aggravatedLLTMedDRA10048391 Muscle weakness left-sidedLLTMedDRA10065780 Muscle weakness lower limbLLTMedDRA10065776 Muscle weakness right-sidedLLTMedDRA10065794 Muscle weakness trunkLLTMedDRA10065795 Muscle weakness upper limbLLTMedDRA10065895 Muscle weakness upper limbPTCTCAE Muscle weaknessLLTMedDRA10028350 Muscular weaknessLLTMedDRA10028372 MyastheniaLLTMedDRA10028415 Neuromuscular weaknessLLTMedDRA10062976 Weakness in extremityLLTMedDRA10065702 Weakness muscleLLTMedDRA10047867 Weakness of armsLLTMedDRA10050379 Weakness of limbsLLTMedDRA10047868 Weakness voluntary muscleLLTMedDRA10047870 C78459 E12471 Muscle weakness upper limb Musculoskeletal and connective tissue disorder - Other, specify Musculoskeletal and connective tissue disorder - Other, specifyPTCTCAE E12475 Musculoskeletal and connective tissue disorder - Other, specify Musculoskeletal and connective tissue disorders 10028395 Musculoskeletal and connective tissue disordersPTCTCAE E13872 Musculoskeletal and connective tissue disorders Musculoskeletal deformity 10065783 NCIA disorder characterized by of a malformation of the musculoskeletal system. Musculoskeletal deformityLLTMedDRA10065783 Musculoskeletal deformityPTCTCAE C78488 E12481 Musculoskeletal deformity Myalgia 10028411 NCIA disorder characterized by marked discomfort sensation originating from a muscle or group of muscles. Generalised muscle achesLLTMedDRA10018089 Generalized muscle achesLLTMedDRA10062441 Localised muscle painLLTMedDRA10063543 Localized muscle painLLTMedDRA10063545 Muscle acheLLTMedDRA10028287 Muscle painLLTMedDRA10028322 Muscle sorenessLLTMedDRA10028332 Muscle tenderness any siteLLTMedDRA10028341 Muscular painLLTMedDRA10028361 Muscular painsLLTMedDRA10028362 Myalgia aggravatedLLTMedDRA10048317 Myalgia of lower extremitiesLLTMedDRA10051587 MyalgiaLLTMedDRA10028411 MyalgiaPTCTCAE Pain muscleLLTMedDRA10033466 Polymyalgia aggravatedLLTMedDRA10036098 Polymyalgia worsenedLLTMedDRA10036101 PolymyalgiaLLTMedDRA10036097 Tenderness muscleLLTMedDRA10043230 C27009 E12485 Myalgia Myelitis 10028524 NCIA disorder characterized by inflammation involving the spinal cord. Symptoms include weakness, paresthesia, sensory loss, marked discomfort and incontinence. Myelitis NOSLLTMedDRA10028526 MyelitisLLTMedDRA10028524 MyelitisPTCTCAE MyeloradiculitisLLTMedDRA10062588 C26832 E12732 Myelitis Myelodysplastic syndrome 10028533 NCIA disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow. Myelodysplastic syndromePTCTCAE C3247 E12552 Myelodysplastic syndrome Myocardial infarction 10028596 NCIA disorder characterized by gross necrosis of the myocardium; this is due to an interruption of blood supply to the area. Age indeterminate anterior myocardial infarctionLLTMedDRA10052514 Age indeterminate anterolateral myocardial infarctionLLTMedDRA10058903 Age indeterminate anteroseptal myocardial infarctionLLTMedDRA10057490 Age indeterminate inferior myocardial infarctionLLTMedDRA10052515 Age indeterminate inferolateral myocardial infarctionLLTMedDRA10057543 Age indeterminate inferoposterior myocardial infarctionLLTMedDRA10057544 Age indeterminate lateral myocardial infarctionLLTMedDRA10052516 Age indeterminate myocardial infarctionLLTMedDRA10052475 Age indeterminate posterior myocardial infarctionLLTMedDRA10052517 Age indeterminate posterolateral myocardial infarctionLLTMedDRA10057491 Age indeterminate right ventricular infarctionLLTMedDRA10058224 Age indeterminate septal myocardial infarctionLLTMedDRA10057492 Anterior MILLTMedDRA10002698 Anterior myocardial infarctionLLTMedDRA10057545 Anterolateral myocardial infarctionLLTMedDRA10068109 Anteroseptal infarctionLLTMedDRA10049846 Anteroseptal necrosisLLTMedDRA10049847 Apical myocardial infarctionLLTMedDRA10059869 Attack heart (NOS)LLTMedDRA10003724 Cardiopathy necroticLLTMedDRA10007643 Heart attackLLTMedDRA10019250 Infarct myocardialLLTMedDRA10021758 Inferior MILLTMedDRA10021922 Inferior myocardial infarctionLLTMedDRA10057546 Inferolateral myocardial infarctionLLTMedDRA10057551 Lateral myocardial infarctionLLTMedDRA10057547 Myocardial infarctLLTMedDRA10028595 Myocardial infarction old healedLLTMedDRA10028599 Myocardial infarction oldLLTMedDRA10028598 Myocardial infarctionLLTMedDRA10028596 Myocardial infarctionPTCTCAE Myocardial necrosisLLTMedDRA10028602 Myocardial reinfarctionLLTMedDRA10052318 Necrosis myocardiumLLTMedDRA10028870 Non-Q wave MILLTMedDRA10029506 Old myocardial infarctionLLTMedDRA10030272 Post MILLTMedDRA10036231 Posterior myocardial infarctionLLTMedDRA10057548 Posteroinferior myocardial infarctionLLTMedDRA10058904 Posterolateral myocardial infarctionLLTMedDRA10057550 Q wave MILLTMedDRA10037690 Septal myocardial infarctionLLTMedDRA10057549 Subendocardial myocardial infarctionLLTMedDRA10053558 Transmural myocardial infarctionLLTMedDRA10066673 C27996 E10152 Myocardial infarction Myocarditis 10028606 NCIA disorder characterized by inflammation of the muscle tissue of the heart. Acute myocarditis, unspecifiedLLTMedDRA10000934 Acute myocarditisLLTMedDRA10000932 Allergic myocarditisLLTMedDRA10001715 Idiopathic myocarditisLLTMedDRA10021234 Myocarditis NOSLLTMedDRA10028613 Myocarditis allergicLLTMedDRA10028607 Myocarditis interstitialLLTMedDRA10028611 Myocarditis, unspecifiedLLTMedDRA10028619 MyocarditisLLTMedDRA10028606 MyocarditisPTCTCAE Toxic myocarditisLLTMedDRA10044235 C34831 E10157 Myocarditis Myositis 10028653 NCIA disorder characterized by inflammation involving the skeletal muscles. Granulomatous myositisLLTMedDRA10058957 Interstitial myositisLLTMedDRA10022613 Muscle inflammationLLTMedDRA10028313 MyositisLLTMedDRA10028653 MyositisPTCTCAE Orbital myositisLLTMedDRA10031050 Traumatic myositis ossificansLLTMedDRA10044530 C27578 E12489 Myositis Nail discoloration 10028691 NCIA disorder characterized by a change in the color of the nail plate. Discoloration nailLLTMedDRA10013075 Discolouration nailLLTMedDRA10056121 Fingernail discolorationLLTMedDRA10049922 Fingernail discolourationLLTMedDRA10056127 LeukonychiaLLTMedDRA10050658 Nail discolorationLLTMedDRA10028691 Nail discolorationPTCTCAE Nail discolourationLLTMedDRA10028692 Toenail discolorationLLTMedDRA10068211 Toenail discolourationLLTMedDRA10068212 C78492 E13661 Nail discoloration Nail infection 10061304 NCIA disorder characterized by an infectious process involving the nail. Nail infection NOSLLTMedDRA10049275 Nail infectionLLTMedDRA10061304 Nail infectionPTCTCAE C78493 E11468 Nail infection Nail loss 10049281 NCIA disorder characterized by loss of all or a portion of the nail. Nail lossLLTMedDRA10049281 Nail lossPTCTCAE OnychomadesisLLTMedDRA10049274 C78494 E13663 Nail loss Nail ridging 10062283 NCIA disorder characterized by vertical or horizontal ridges on the nails. Brittle nailsLLTMedDRA10006373 Nail longitudinal striationsLLTMedDRA10056549 Nail ridgingLLTMedDRA10062283 Nail ridgingPTCTCAE OnychoclasisLLTMedDRA10048886 OnychorrhexisLLTMedDRA10056537 OnychoschisisLLTMedDRA10058101 OnychoschiziaLLTMedDRA10056527 Splitting nailsLLTMedDRA10065260 C78499 E13666 Nail ridging Nasal congestion 10028735 NCIA disorder characterized by obstruction of the nasal passage due to mucosal edema. Acute nasal congestionLLTMedDRA10066648 Chronic nasal congestionLLTMedDRA10066647 Congestion nasalLLTMedDRA10010676 Nasal congestionLLTMedDRA10028735 Nasal congestionPTCTCAE Nasal mucosal swellingLLTMedDRA10063455 Nasal obstruction increasedLLTMedDRA10028749 Nasal obstructionLLTMedDRA10028748 Nasal stuffinessLLTMedDRA10028771 Nose congestionLLTMedDRA10029794 Rhinitis medicamentosaLLTMedDRA10039090 Rhinitis medicamentousLLTMedDRA10039091 C78500 E13450 Nasal congestion Nausea 10028813 NCIA disorder characterized by a queasy sensation and/or the urge to vomit. Churning of stomachLLTMedDRA10009165 Feeling queasyLLTMedDRA10016361 Nausea aggravatedLLTMedDRA10048364 Nausea post chemotherapyLLTMedDRA10056989 NauseaLLTMedDRA10028813 NauseaPTCTCAE NauseatedLLTMedDRA10028822 NauseousLLTMedDRA10028823 Postprandial nauseaLLTMedDRA10064349 QueasyLLTMedDRA10037730 C3258 E10878 Nausea Neck edema 10054482 NCIA disorder characterized by swelling due to an accumulation of excessive fluid in the neck. Edema abdomenLLTMedDRA10054486 Edema auricularLLTMedDRA10054488 Edema trunkLLTMedDRA10058720 Localised oedemaLLTMedDRA10048961 Localized edemaLLTMedDRA10062466 Lumbar cushionLLTMedDRA10024990 Neck edema ofLLTMedDRA10055407 Neck edemaLLTMedDRA10054482 Neck edemaPTCTCAE Neck oedema ofLLTMedDRA10028835 Neck oedemaLLTMedDRA10028834 Oedema abdomenLLTMedDRA10048651 Oedema auricularLLTMedDRA10030097 Oedema trunkLLTMedDRA10058691 Sacral edemaLLTMedDRA10039349 Sacral oedemaLLTMedDRA10039350 C78501 E11159 Neck edema Neck pain 10028836 NCIA disorder characterized by marked discomfort sensation in the neck area. Acute cervical painLLTMedDRA10000690 Cervical painLLTMedDRA10008296 CervicalgiaLLTMedDRA10008322 CervicodyniaLLTMedDRA10049860 Neck painLLTMedDRA10028836 Neck painPTCTCAE Pain neckLLTMedDRA10033467 C50663 E12493 Neck pain Neck soft tissue necrosis 10065781 NCIA disorder characterized by a necrotic process occurring in the soft tissues of the neck. Abdominal soft tissue necrosisLLTMedDRA10065775 Head soft tissue necrosisLLTMedDRA10065779 Neck soft tissue necrosisLLTMedDRA10065781 Neck soft tissue necrosisPTCTCAE Pelvic soft tissue necrosisLLTMedDRA10065793 Soft tissue necrosis lower limbLLTMedDRA10065777 Soft tissue necrosis upper limbLLTMedDRA10065778 Soft tissue necrosisLLTMedDRA10065769 C78502 E12497 Neck soft tissue necrosis Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10029104 Neoplasms benign, malignant and unspecified (incl cysts and polyps)PTCTCAE E13864 Neoplasms benign, malignant and unspecified (incl cysts and polyps) Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specifyPTCTCAE E12555 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify Nervous system disorders 10029205 Nervous system disordersPTCTCAE E13868 Nervous system disorders Nervous system disorders - Other, specify Nervous system disorders - Other, specifyPTCTCAE E12738 Nervous system disorders - Other, specify Neuralgia 10029223 NCIA disorder characterized by intense painful sensation along a nerve or group of nerves. Nerve painLLTMedDRA10029181 Neuralgia NOSLLTMedDRA10029226 Neuralgia affecting finger tipsLLTMedDRA10029224 NeuralgiaLLTMedDRA10029223 NeuralgiaPTCTCAE Neurogenic painLLTMedDRA10050800 Neuropathic painLLTMedDRA10054095 Pain nerveLLTMedDRA10033469 C79695 E12744 Neuralgia Neutrophil count decreased 10029366 NCIA finding based on laboratory test results that indicate a decrease in number of neutrophils in a blood specimen. Neutrophil count decreasedPTCTCAE C80520 E12198 Neutrophil count decreased Night blindness 10029404 NCIA disorder characterized by an inability to see clearly in dim light. Accommodation dark disorderLLTMedDRA10000386 Acquired night blindnessLLTMedDRA10000573 Blindness nightLLTMedDRA10005181 Dark accommodation disorderLLTMedDRA10011861 Decreased night visionLLTMedDRA10011974 Disorder dark accommodationLLTMedDRA10013212 Night blindness associated with vitamin A deficiencyLLTMedDRA10029406 Night blindness, unspecifiedLLTMedDRA10029407 Night blindnessLLTMedDRA10029404 Night blindnessPTCTCAE NyctalopiaLLTMedDRA10029862 Vision loss nightLLTMedDRA10047523 Vitamin A deficiency with night blindnessLLTMedDRA10047596 C34850 E10401 Night blindness Nipple deformity 10065823 NCIA disorder characterized by a malformation of the nipple. Cracked nipple associated with childbirthLLTMedDRA10011278 Cracked nippleLLTMedDRA10011276 Fissure of nippleLLTMedDRA10016714 Nipple deformityLLTMedDRA10065823 Nipple deformityPTCTCAE Nipple disorderLLTMedDRA10029417 C78503 E13138 Nipple deformity Non-cardiac chest pain 10062501 NCIA disorder characterized by discomfort in the chest unrelated to a heart disorder. Chest pain (non-cardiac)LLTMedDRA10008480 Non-cardiac chest painLLTMedDRA10062501 Non-cardiac chest painPTCTCAE C78504 E11163 Non-cardiac chest pain Nystagmus 10029864 NCIA disorder characterized by involuntary movements of the eyeballs. Dissociated nystagmusLLTMedDRA10013456 Latent nystagmusLLTMedDRA10024018 Nystagmus NOSLLTMedDRA10029868 Nystagmus, unspecifiedLLTMedDRA10029869 NystagmusLLTMedDRA10029864 NystagmusPTCTCAE Spasmus nutansLLTMedDRA10059593 Visual deprivation nystagmusLLTMedDRA10047539 C3282 E12748 Nystagmus Obesity 10029883 NCIA disorder characterized by having a high amount of body fat. AdiposisLLTMedDRA10001293 Adipositas per magnaLLTMedDRA10052626 AdipositasLLTMedDRA10051361 Gross obesityLLTMedDRA10018743 Morbid obesityLLTMedDRA10027966 Obesity, unspecifiedLLTMedDRA10029885 ObesityLLTMedDRA10029883 ObesityPTCTCAE C3283 E12361 Obesity Obstruction gastric 10029957 NCIA disorder characterized by blockage of the normal flow of the contents in the stomach. Acquired hypertrophic pyloric stenosisLLTMedDRA10000556 Acquired pyloric stenosisLLTMedDRA10056374 Adult hypertrophic pyloric stenosisLLTMedDRA10001404 Bouveret syndrome ILLTMedDRA10064757 Gastric outlet obstructionLLTMedDRA10062499 Obstruction gastricLLTMedDRA10029957 Obstruction gastricPTCTCAE C78505 E10882 Obstruction gastric Oculomotor nerve disorder 10053661 NCIA disorder characterized by involvement of the oculomotor nerve (third cranial nerve). IIIrd nerve disorderLLTMedDRA10053644 Oculomotor nerve disorderLLTMedDRA10053661 Oculomotor nerve disorderPTCTCAE C27598 E12751 Oculomotor nerve disorder Olfactory nerve disorder 10056388 NCIA disorder characterized by involvement of the olfactory nerve (first cranial nerve). Olfactory nerve disorderLLTMedDRA10056388 Olfactory nerve disorderPTCTCAE C27210 E12755 Olfactory nerve disorder Oligospermia 10030300 NCIA disorder characterized by a decrease in the number of spermatozoa in the semen. AzoospermiaLLTMedDRA10003883 OligospermiaLLTMedDRA10030300 OligospermiaPTCTCAE OligozoospermiaLLTMedDRA10030301 Spermatogenesis arrestLLTMedDRA10041494 Spermatogenesis arrestedLLTMedDRA10041495 Spermatogenesis reversible inhibition ofLLTMedDRA10041496 C34860 E13141 Oligospermia Optic nerve disorder 10061322 NCIA disorder characterized by involvement of the optic nerve (second cranial nerve). Optic nerve disorder NOSLLTMedDRA10030932 Optic nerve disorderLLTMedDRA10061322 Optic nerve disorderPTCTCAE C79698 E10406 Optic nerve disorder Oral cavity fistula 10065720 NCIA disorder characterized by an abnormal communication between the oral cavity and another organ or anatomic site. Oral cavity fistulaLLTMedDRA10065720 Oral cavity fistulaPTCTCAE C78506 E10888 Oral cavity fistula Oral dysesthesia 10054520 NCIA disorder characterized by a burning or tingling sensation on the lips, tongue or entire mouth. Dysaesthesia of lipsLLTMedDRA10062821 Dysaesthesia of tongueLLTMedDRA10062822 Dysesthesia of lipsLLTMedDRA10049920 Dysesthesia of tongueLLTMedDRA10049921 Oral dysaesthesiaLLTMedDRA10050820 Oral dysesthesiaLLTMedDRA10054520 Oral dysesthesiaPTCTCAE Vincent's symptomLLTMedDRA10066255 C62545 E10894 Oral dysesthesia Oral hemorrhage 10030980 NCIA disorder characterized by bleeding from the mouth. Bleeding mouthLLTMedDRA10049331 Haemorrhage mouthLLTMedDRA10055823 Haemorrhage of mouthLLTMedDRA10055831 Haemorrhage oralLLTMedDRA10055833 Hemorrhage mouthLLTMedDRA10019559 Hemorrhage of mouthLLTMedDRA10019570 Hemorrhage oralLLTMedDRA10019574 Mouth haemorrhageLLTMedDRA10028024 Mouth hemorrhageLLTMedDRA10028025 Oral haemorrhageLLTMedDRA10030978 Oral hemorrhageLLTMedDRA10030980 Oral hemorrhagePTCTCAE Oral mucosa bleedingLLTMedDRA10030985 Oral mucosa ecchymosisLLTMedDRA10030989 Oral mucosal petechiaeLLTMedDRA10030998 Petechiae oral mucosaLLTMedDRA10034755 C79699 E10898 Oral hemorrhage Oral pain 10031009 NCIA disorder characterized by a sensation of marked discomfort in the mouth, tongue or lips. Mouth painLLTMedDRA10028030 Oral angular painLLTMedDRA10030959 Oral mucosa painLLTMedDRA10030990 Oral painLLTMedDRA10031009 Oral painPTCTCAE Pain mouthLLTMedDRA10033464 Pain oralLLTMedDRA10033476 Sensitive mouthLLTMedDRA10049308 Sore mouthLLTMedDRA10041362 Stinging mouthLLTMedDRA10049310 Tender mouthLLTMedDRA10049309 C78509 E10904 Oral pain Osteonecrosis of jaw 10064658 NCIA disorder characterized by a necrotic process occurring in the bone of the mandible. Osteonecrosis of jawPTCTCAE C63924 E12502 Osteonecrosis of jaw Osteoporosis 10031282 NCIA disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Bone fragileLLTMedDRA10005966 Disuse osteoporosisLLTMedDRA10013522 Idiopathic osteoporosisLLTMedDRA10021236 OsteoporomalaciaLLTMedDRA10065320 Osteoporosis NOSLLTMedDRA10031284 Osteoporosis steroid-inducedLLTMedDRA10031287 Osteoporosis, unspecifiedLLTMedDRA10031289 OsteoporosisLLTMedDRA10031282 OsteoporosisPTCTCAE C3298 E12508 Osteoporosis Otitis externa 10033072 NCIA disorder characterized by an infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer's ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and marked discomfort in the ear and ear drainage. Acute infection of pinnaLLTMedDRA10000810 Acute swimmers' earLLTMedDRA10001090 Bilateral otitis externaLLTMedDRA10004572 External ear infection NOSLLTMedDRA10015735 Infection of the outer earLLTMedDRA10021853 Infective otitis externa, unspecifiedLLTMedDRA10021920 Infective otitis externaLLTMedDRA10021919 Left otitis externaLLTMedDRA10024112 Malignant otitis externaLLTMedDRA10026661 Other acute otitis externaLLTMedDRA10031468 Otitis externa (excl boil of meatus) NOSLLTMedDRA10033075 Otitis externa (excl boil of meatus)LLTMedDRA10033073 Otitis externa NOSLLTMedDRA10052558 Otitis externaLLTMedDRA10033072 Otitis externaPTCTCAE Right otitis externaLLTMedDRA10039158 C3299 E11472 Otitis externa Otitis media 10033078 NCIA disorder characterized by an infectious process involving the middle ear. Bilateral otitis mediaLLTMedDRA10004573 Catarrh of middle earLLTMedDRA10056747 Glue earLLTMedDRA10018447 Middle ear infectionLLTMedDRA10027585 Non-suppurative otitis mediaLLTMedDRA10029564 Otitis media NOSLLTMedDRA10033084 Otitis media recurrentLLTMedDRA10066713 Otitis media serous NOSLLTMedDRA10033091 Otitis media serousLLTMedDRA10033086 Otitis media suppurative NOSLLTMedDRA10033097 Otitis media suppurativeLLTMedDRA10033092 Otitis mediaLLTMedDRA10033078 Otitis mediaPTCTCAE Secretory otitis mediaLLTMedDRA10039895 Serous otitis media (glue ear)LLTMedDRA10040113 Unspecified otitis mediaLLTMedDRA10046087 Unspecified suppurative otitis mediaLLTMedDRA10046177 C34885 E11477 Otitis media Ovarian hemorrhage 10065763 NCIA disorder characterized by bleeding from the ovary. Ovarian haemorrhageLLTMedDRA10065741 Ovarian hemorrhageLLTMedDRA10065763 Ovarian hemorrhagePTCTCAE C78511 E13145 Ovarian hemorrhage Ovarian infection 10055005 NCIA disorder characterized by an infectious process involving the ovary. Ovarian infectionLLTMedDRA10055005 Ovarian infectionPTCTCAE C78512 E11482 Ovarian infection Ovarian rupture 10033279 NCIA disorder characterized by tearing or disruption of the ovarian tissue. Ovarian ruptureLLTMedDRA10033279 Ovarian rupturePTCTCAE C78513 E13151 Ovarian rupture Ovulation pain 10033314 NCIA disorder characterized by marked discomfort sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle. Intermenstrual painLLTMedDRA10048603 Mid cycle painLLTMedDRA10027567 MittelschmerzLLTMedDRA10027737 Ovulation painLLTMedDRA10033314 Ovulation painPTCTCAE Ovulation painfulLLTMedDRA10048588 C78514 E13157 Ovulation pain Pain 10033371 NCIA disorder characterized by the sensation of marked discomfort, distress or agony. Ache NOSLLTMedDRA10000428 AcheLLTMedDRA10000424 Acute painLLTMedDRA10066714 Chronic painLLTMedDRA10049475 Exacerbation of painLLTMedDRA10015579 General body painLLTMedDRA10048971 Generalised achingLLTMedDRA10018074 Generalized achingLLTMedDRA10062428 Intractable painLLTMedDRA10059050 Irradiating painLLTMedDRA10052411 Lancinating painLLTMedDRA10052412 Pain NOSLLTMedDRA10033470 Pain aggravatedLLTMedDRA10033376 Pain at restLLTMedDRA10059073 Pain burningLLTMedDRA10033386 Pain dullLLTMedDRA10033392 Pain exacerbatedLLTMedDRA10033396 Pain irritatedLLTMedDRA10033454 Pain localisedLLTMedDRA10050483 Pain localizedLLTMedDRA10069139 Pain mucosalLLTMedDRA10033465 Pain upon movementLLTMedDRA10068309 Pain worsenedLLTMedDRA10033499 PainLLTMedDRA10033371 PainPTCTCAE Premenstrual painLLTMedDRA10065347 Prick pain feelingLLTMedDRA10036663 Prick painLLTMedDRA10036662 Shooting painLLTMedDRA10050007 StingingLLTMedDRA10042066 Throbbing painLLTMedDRA10056359 Trigger point painLLTMedDRA10065997 C3303 E11167 Pain Pain in extremity 10033425 NCIA disorder characterized by marked discomfort sensation in the upper or lower extremities. Aches & pains in legsLLTMedDRA10000431 Aching in limbLLTMedDRA10000448 Aching pain in hands, forearms, elbowsLLTMedDRA10000450 BrachialgiaLLTMedDRA10068901 Calf painLLTMedDRA10007031 Foot painLLTMedDRA10016974 Hand painLLTMedDRA10019116 Leg painLLTMedDRA10024130 MelalgiaLLTMedDRA10059671 Pain footLLTMedDRA10033400 Pain in armLLTMedDRA10033421 Pain in calfLLTMedDRA10033422 Pain in extremityLLTMedDRA10033425 Pain in extremityPTCTCAE Pain in fingersLLTMedDRA10033428 Pain in footLLTMedDRA10033429 Pain in handLLTMedDRA10033430 Pain in heelLLTMedDRA10033431 Pain in legLLTMedDRA10033446 Pain in limbLLTMedDRA10033447 Pain in thighLLTMedDRA10048973 Pain in thumbLLTMedDRA10033451 Pain in toeLLTMedDRA10033452 Pain legsLLTMedDRA10033459 Pain of extremitiesLLTMedDRA10033471 Pain of lower extremitiesLLTMedDRA10033473 Pain on lower thighLLTMedDRA10033475 Painful L armLLTMedDRA10033513 Painful R armLLTMedDRA10033515 Painful armLLTMedDRA10033503 Painful feetLLTMedDRA10033506 Painful handLLTMedDRA10033508 Pains in legsLLTMedDRA10033522 Sore feetLLTMedDRA10041358 Unilateral leg painLLTMedDRA10052410 C78515 E12512 Pain in extremity Pain of skin 10033474 NCIA disorder characterized by marked discomfort sensation in the skin. Pain of skinLLTMedDRA10033474 Pain of skinPTCTCAE Scalp painLLTMedDRA10049120 Scalp tendernessLLTMedDRA10039521 Skin tendernessLLTMedDRA10051797 Stinging skinLLTMedDRA10065061 C78516 E13668 Pain of skin Palmar-plantar erythrodysesthesia syndrome 10054524 NCIA disorder characterized by redness, marked discomfort, swelling, and tingling in the palms of the hands or the soles of the feet. Hand and foot syndrome secondary to chemotherapyLLTMedDRA10048776 Hand and foot syndromeLLTMedDRA10019111 Hand-and-foot syndromeLLTMedDRA10019126 Palmar-plantar erythemaLLTMedDRA10063069 Palmar-plantar erythrodysaesthesia syndromeLLTMedDRA10033553 Palmar-plantar erythrodysesthesia syndromeLLTMedDRA10054524 Palmar-plantar erythrodysesthesia syndromePTCTCAE C27177 E13672 Palmar-plantar erythrodysesthesia syndrome Palpitations 10033557 NCIA disorder characterized by an unpleasant sensation of irregular and/or forceful beating of the heart. Heart poundingLLTMedDRA10019297 Heart racingLLTMedDRA10066996 Heart throbbingLLTMedDRA10019313 PalpitationLLTMedDRA10033556 Palpitations aggravatedLLTMedDRA10048351 PalpitationsLLTMedDRA10033557 PalpitationsPTCTCAE C37999 E10163 Palpitations Pancreas infection 10051741 NCIA disorder characterized by an infectious process involving the pancreas. Pancreas infectionLLTMedDRA10051741 Pancreas infectionPTCTCAE Pancreatic pseudocyst infectionLLTMedDRA10057089 C78517 E11487 Pancreas infection Pancreatic anastomotic leak 10050457 NCIA finding of leakage due to breakdown of a pancreatic anastomosis (surgical connection of two separate anatomic structures). Pancreatic anastomotic leakLLTMedDRA10050457 Pancreatic anastomotic leakPTCTCAE Pancreatic leakLLTMedDRA10063350 C78518 E11891 Pancreatic anastomotic leak Pancreatic duct stenosis 10065703 NCIA disorder characterized by a narrowing of the lumen of the pancreatic duct. Pancreatic duct stenosisLLTMedDRA10065703 Pancreatic duct stenosisPTCTCAE C78519 E10908 Pancreatic duct stenosis Pancreatic enzymes decreased 10062646 NCIA finding based on laboratory test results that indicate an decrease in levels of pancreatic enzymes in a biological specimen. Pancreas enzymes decreasedLLTMedDRA10033583 Pancreatic enzyme decreasedLLTMedDRA10061329 Pancreatic enzymes NOS decreasedLLTMedDRA10033622 Pancreatic enzymes decreasedLLTMedDRA10062646 Pancreatic enzymes decreasedPTCTCAE C78520 E12203 Pancreatic enzymes decreased Pancreatic fistula 10049192 NCIA disorder characterized by an abnormal communication between the pancreas and another organ or anatomic site. Pancreatic fistulaLLTMedDRA10049192 Pancreatic fistulaPTCTCAE C79701 E10914 Pancreatic fistula Pancreatic hemorrhage 10033626 NCIA disorder characterized by bleeding from the pancreas. Pancreas haemorrhageLLTMedDRA10033588 Pancreas hemorrhageLLTMedDRA10055312 Pancreatic haemorrhageLLTMedDRA10033625 Pancreatic hemorrhageLLTMedDRA10033626 Pancreatic hemorrhagePTCTCAE C78521 E10920 Pancreatic hemorrhage Pancreatic necrosis 10058096 NCIA disorder characterized by a necrotic process occurring in the pancreas. Pancreatic necrosisLLTMedDRA10058096 Pancreatic necrosisPTCTCAE C78522 E10926 Pancreatic necrosis Pancreatitis 10033645 NCIA disorder characterized by inflammation of the pancreas. Mass forming pancreatitisLLTMedDRA10059155 Pancreatitis NOSLLTMedDRA10033656 Pancreatitis aggravatedLLTMedDRA10048365 Pancreatitis due to biliary obstructionLLTMedDRA10057010 Pancreatitis due to gallstonesLLTMedDRA10050844 Pancreatitis steroid-inducedLLTMedDRA10033658 PancreatitisLLTMedDRA10033645 PancreatitisPTCTCAE Toxic pancreatitisLLTMedDRA10067190 C3306 E10930 Pancreatitis Papilledema 10033703 NCIA disorder characterized by swelling around the optic disc. Disc congestion in ocular fundusLLTMedDRA10013058 Disc edema in ocular fundusLLTMedDRA10055401 Disc oedema in ocular fundusLLTMedDRA10013061 Disc redness in ocular fundusLLTMedDRA10013062 Optic disc engorgementLLTMedDRA10030918 Optic nerve congestionLLTMedDRA10030929 Optic nerve edemaLLTMedDRA10030934 Optic nerve oedemaLLTMedDRA10030940 Papilledema, unspecifiedLLTMedDRA10033707 PapilledemaLLTMedDRA10033703 PapilledemaPTCTCAE Papilloedema, unspecifiedLLTMedDRA10055949 PapilloedemaLLTMedDRA10033712 C3307 E10411 Papilledema Papulopustular rash 10069138 NCIA disorder characterized by an eruption consisting of papules (a small, raised pimple) and pustules (a small pus filled blister), typically appearing in face, scalp, and upper chest and back Unlike acne, this rash does not present with whiteheads or blackheads, and can be symptomatic, with itchy or tender lesions. Papulopustular rashLLTMedDRA10069138 Papulopustular rashPTCTCAE Pustular rashLLTMedDRA10037576 Pustular skin eruptionLLTMedDRA10037577 PustuleLLTMedDRA10037578 Pustules on handLLTMedDRA10037579 Rash pustularLLTMedDRA10037888 Rash vesiculo-pustularLLTMedDRA10037900 Rash vesiculopustularLLTMedDRA10037902 Vesiculo-pustular rashLLTMedDRA10047380 Vesiculopustular rashLLTMedDRA10047382 C80119 E11491 Papulopustular rash Paresthesia 10033987 NCIA disorder characterized by functional disturbances of sensory neurons resulting in abnormal cutaneous sensations of tingling, numbness, pressure, cold, and warmth that are experienced in the absence of a stimulus. Abnormal touch sensationLLTMedDRA10000184 AcroparaesthesiaLLTMedDRA10000604 AcroparesthesiaLLTMedDRA10062860 Disturbance of skin sensationLLTMedDRA10013508 Electric shock sensationLLTMedDRA10014358 Facial paraesthesiaLLTMedDRA10016061 Facial paresthesiaLLTMedDRA10062815 Localised tinglingLLTMedDRA10066427 Localized tinglingLLTMedDRA10066420 Paraesthesia aggravatedLLTMedDRA10066539 Paraesthesia distalLLTMedDRA10033777 Paraesthesia earLLTMedDRA10052433 Paraesthesia footLLTMedDRA10052407 Paraesthesia generalisedLLTMedDRA10033778 Paraesthesia handLLTMedDRA10049230 Paraesthesia lower limbLLTMedDRA10052409 Paraesthesia of fingersLLTMedDRA10033783 Paraesthesia of limbsLLTMedDRA10033784 Paraesthesia of scalpLLTMedDRA10048879 Paraesthesia skinLLTMedDRA10033786 Paraesthesia upper limbLLTMedDRA10052408 ParaesthesiaLLTMedDRA10033775 Paresthesia aggravatedLLTMedDRA10066540 Paresthesia distalLLTMedDRA10033989 Paresthesia earLLTMedDRA10054526 Paresthesia footLLTMedDRA10054527 Paresthesia generalizedLLTMedDRA10054528 Paresthesia handLLTMedDRA10054530 Paresthesia lower limbLLTMedDRA10054531 Paresthesia of fingersLLTMedDRA10054532 Paresthesia of limbsLLTMedDRA10054534 Paresthesia of scalpLLTMedDRA10054536 Paresthesia skinLLTMedDRA10033992 Paresthesia upper limbLLTMedDRA10054539 ParesthesiaLLTMedDRA10033987 ParesthesiaPTCTCAE Pins and needlesLLTMedDRA10035067 Pricking skin sensationLLTMedDRA10036665 Prickling of handLLTMedDRA10036666 Tingling feet/handsLLTMedDRA10043877 Tingling of extremityLLTMedDRA10063451 Tingling sensationLLTMedDRA10043880 Tingling skinLLTMedDRA10043881 TinglingLLTMedDRA10043876 C28177 E12758 Paresthesia Paronychia 10034016 NCIA disorder characterized by an infectious process involving the soft tissues around the nail. FelonLLTMedDRA10016378 Infected ingrowing toe nailLLTMedDRA10021777 Infection ingrowing toenailLLTMedDRA10021833 OnychiaLLTMedDRA10030333 PanaritiumLLTMedDRA10059850 ParonychiaLLTMedDRA10034016 ParonychiaPTCTCAE PerionychitisLLTMedDRA10063010 WhitlowLLTMedDRA10059856 C79702 E11497 Paronychia Paroxysmal atrial tachycardia 10034040 NCIA disorder characterized by a dysrhythmia with abrupt onset and sudden termination of atrial contractions with a rate of 150-250 beats per minute. The rhythm disturbance originates in the atria. Atrial tachycardiaLLTMedDRA10003668 Multifocal atrial tachycardiaLLTMedDRA10052350 Paroxysmal atrial tachycardiaLLTMedDRA10034040 Paroxysmal atrial tachycardiaPTCTCAE Tachycardia atrialLLTMedDRA10043073 Tachycardia paroxysmal atrialLLTMedDRA10043080 C34900 E10166 Paroxysmal atrial tachycardia Pelvic floor muscle weakness 10064026 NCIA disorder characterized by a reduction in the strength of the muscles of the pelvic floor. Pelvic floor muscle weaknessLLTMedDRA10064026 Pelvic floor muscle weaknessPTCTCAE Pelvic muscles inadequateLLTMedDRA10034261 C78524 E13161 Pelvic floor muscle weakness Pelvic infection 10058674 NCIA disorder characterized by an infectious process involving the pelvic cavity. Pelvic infectionLLTMedDRA10058674 Pelvic infectionPTCTCAE C3889 E11501 Pelvic infection Pelvic pain 10034263 NCIA disorder characterized by marked discomfort sensation in the pelvis. Chronic pelvic pain syndromeLLTMedDRA10064189 Pain pelvicLLTMedDRA10033479 Pelvic pain NOS (female)LLTMedDRA10034265 Pelvic pain NOSLLTMedDRA10034264 Pelvic pain femaleLLTMedDRA10048581 Pelvic painLLTMedDRA10034263 Pelvic painPTCTCAE C40122 E13167 Pelvic pain Pelvic soft tissue necrosis 10065793 NCIA disorder characterized by a necrotic process occurring in the soft tissues of the pelvis. Abdominal soft tissue necrosisLLTMedDRA10065775 Head soft tissue necrosisLLTMedDRA10065779 Neck soft tissue necrosisLLTMedDRA10065781 Pelvic soft tissue necrosisLLTMedDRA10065793 Pelvic soft tissue necrosisPTCTCAE Soft tissue necrosis lower limbLLTMedDRA10065777 Soft tissue necrosis upper limbLLTMedDRA10065778 Soft tissue necrosisLLTMedDRA10065769 C78525 E12516 Pelvic soft tissue necrosis Penile infection 10061912 NCIA disorder characterized by an infectious process involving the penis. Penile infection NOSLLTMedDRA10034306 Penile infectionLLTMedDRA10061912 Penile infectionPTCTCAE C78526 E11506 Penile infection Penile pain 10034310 NCIA disorder characterized by marked discomfort sensation in the penis. Penile painLLTMedDRA10034310 Penile painPTCTCAE C78527 E13171 Penile pain Perforation bile duct 10034405 NCIA disorder characterized by a rupture in the wall of the extrahepatic or intrahepatic bile duct. Perforation bile ductLLTMedDRA10034405 Perforation bile ductPTCTCAE Perforation of bile ductLLTMedDRA10034417 C78528 E11234 Perforation bile duct Pericardial effusion 10034474 NCIA disorder characterized by fluid collection within the pericardial sac, usually due to inflammation. Effusion pericardialLLTMedDRA10014311 Pericardial effusionLLTMedDRA10034474 Pericardial effusionPTCTCAE Pericardial fluid exudateLLTMedDRA10059935 C3319 E10172 Pericardial effusion Pericardial tamponade 10053565 NCIA disorder characterized by an increase in intrapericardial pressure due to the collection of blood or fluid in the pericardium. Cardiac tamponadeLLTMedDRA10007610 Pericardial tamponadeLLTMedDRA10053565 Pericardial tamponadePTCTCAE Tamponade cardiacLLTMedDRA10043113 C50481 E10177 Pericardial tamponade Pericarditis 10034484 NCIA disorder characterized by irritation to the layers of the pericardium (the protective sac around the heart). Acute idiopathic pericarditisLLTMedDRA10000809 Acute pericarditis, unspecifiedLLTMedDRA10000998 Acute pericarditisLLTMedDRA10000996 Pericarditis NOSLLTMedDRA10034495 Pericarditis epistenocardiacaLLTMedDRA10066340 Pericarditis siccaLLTMedDRA10065376 PericarditisLLTMedDRA10034484 PericarditisPTCTCAE Subacute pericarditisLLTMedDRA10066718 C34915 E10180 Pericarditis Perineal pain 10061339 NCIA disorder characterized by a sensation of marked discomfort in the area between the genital organs and the anus. Perineal pain NOSLLTMedDRA10034527 Perineal pain femaleLLTMedDRA10034525 Perineal pain maleLLTMedDRA10034526 Perineal painLLTMedDRA10061339 Perineal painPTCTCAE Perineal sensation of burningLLTMedDRA10058058 C78529 E13175 Perineal pain Periodontal disease 10034536 NCIA disorder in the gingival tissue around the teeth. Gingival reactionLLTMedDRA10018289 Periodontal diseaseLLTMedDRA10034536 Periodontal diseasePTCTCAE Periodontal disorder NOSLLTMedDRA10034537 C63743 E10935 Periodontal disease Periorbital edema 10054541 NCIA disorder characterized by swelling due to an excessive accumulation of fluid around the orbits of the face. Edema periorbitalLLTMedDRA10014250 Oedema periorbitalLLTMedDRA10030123 Periorbital edemaLLTMedDRA10054541 Periorbital edemaPTCTCAE Periorbital oedemaLLTMedDRA10034545 C78530 E13676 Periorbital edema Periorbital infection 10051472 NCIA disorder characterized by an infectious process involving the orbit of the eye. Periorbital infectionLLTMedDRA10051472 Periorbital infectionPTCTCAE C78531 E11511 Periorbital infection Peripheral ischemia 10034578 NCIA disorder characterized by impaired circulation to an extremity. Critical limb ischaemiaLLTMedDRA10058072 Critical limb ischemiaLLTMedDRA10058069 Ischaemia peripheralLLTMedDRA10023020 Ischemia peripheralLLTMedDRA10023034 Leg ischaemiaLLTMedDRA10066918 Leg ischemiaLLTMedDRA10066920 Peripheral ischaemia NOSLLTMedDRA10034577 Peripheral ischaemiaLLTMedDRA10034576 Peripheral ischemia NOSLLTMedDRA10034579 Peripheral ischemiaLLTMedDRA10034578 Peripheral ischemiaPTCTCAE C78535 E13810 Peripheral ischemia Peripheral motor neuropathy 10034580 NCIA disorder characterized by inflammation or degeneration of the peripheral motor nerves. Motor peripheral neuropathyLLTMedDRA10028005 Peripheral motor neuropathyLLTMedDRA10034580 Peripheral motor neuropathyPTCTCAE C3500 E12762 Peripheral motor neuropathy Peripheral nerve infection 10065766 NCIA disorder characterized by an infectious process involving the peripheral nerves. Peripheral nerve infectionLLTMedDRA10065766 Peripheral nerve infectionPTCTCAE C27589 E11516 Peripheral nerve infection Peripheral sensory neuropathy 10034620 NCIA disorder characterized by inflammation or degeneration of the peripheral sensory nerves. Peripheral sensory neuropathyLLTMedDRA10034620 Peripheral sensory neuropathyPTCTCAE Sensory neuropathyLLTMedDRA10062975 Sensory peripheral neuropathiesLLTMedDRA10040038 Sensory peripheral neuropathyLLTMedDRA10040039 Sensory polyneuropathy axonalLLTMedDRA10040040 C3501 E12768 Peripheral sensory neuropathy Peritoneal infection 10057262 NCIA disorder characterized by an infectious process involving the peritoneum. Ascites infectionLLTMedDRA10051156 Peritoneal infectionLLTMedDRA10057262 Peritoneal infectionPTCTCAE Peritonitis suppurativeLLTMedDRA10034683 Suppurative peritonitis, otherLLTMedDRA10042588 C78540 E11521 Peritoneal infection Peritoneal necrosis 10065704 NCIA disorder characterized by a necrotic process occurring in the peritoneum. Peritoneal necrosisLLTMedDRA10065704 Peritoneal necrosisPTCTCAE C78543 E10939 Peritoneal necrosis Personality change 10034719 NCIA disorder characterized by a conspicuous change in a person's behavior and thinking. Attitude changeLLTMedDRA10003743 Attitude changedLLTMedDRA10003744 Character change inLLTMedDRA10008407 Character changeLLTMedDRA10008406 Personality changeLLTMedDRA10034719 Personality changePTCTCAE C78548 E12942 Personality change Phantom pain 10056238 NCIA disorder characterized by marked discomfort related to a limb or an organ that is removed from or is not physically part of the body. Phantom limb painLLTMedDRA10034804 Phantom painLLTMedDRA10056238 Phantom painPTCTCAE C79703 E12774 Phantom pain Pharyngeal anastomotic leak 10065705 NCIA finding of leakage due to breakdown of a pharyngeal anastomosis (surgical connection of two separate anatomic structures). Pharyngeal anastomotic leakLLTMedDRA10065705 Pharyngeal anastomotic leakPTCTCAE C78550 E11897 Pharyngeal anastomotic leak Pharyngeal fistula 10034825 NCIA disorder characterized by an abnormal communication between the pharynx and another organ or anatomic site. Pharyngeal fistulaLLTMedDRA10034825 Pharyngeal fistulaPTCTCAE C78551 E13454 Pharyngeal fistula Pharyngeal hemorrhage 10055315 NCIA disorder characterized by bleeding from the pharynx. Haemorrhage from throatLLTMedDRA10018976 Haemorrhage pharyngealLLTMedDRA10018995 Hemorrhage from throatLLTMedDRA10019541 Hemorrhage pharyngealLLTMedDRA10055271 Oropharyngeal haemorrhageLLTMedDRA10060846 Oropharyngeal hemorrhageLLTMedDRA10060843 Pharyngeal haemorrhageLLTMedDRA10034827 Pharyngeal hemorrhageLLTMedDRA10055315 Pharyngeal hemorrhagePTCTCAE C26986 E13460 Pharyngeal hemorrhage Pharyngeal mucositis 10065881 NCIA disorder characterized by an inflammation involving the mucous membrane of the pharynx. Pharyngeal inflammationLLTMedDRA10065716 Pharyngeal mucositisLLTMedDRA10065881 Pharyngeal mucositisPTCTCAE C78553 E13466 Pharyngeal mucositis Pharyngeal necrosis 10065706 NCIA disorder characterized by a necrotic process occurring in the pharynx. Pharyngeal necrosisLLTMedDRA10065706 Pharyngeal necrosisPTCTCAE C78554 E13472 Pharyngeal necrosis Pharyngeal stenosis 10050028 NCIA disorder characterized by a narrowing of the pharyngeal airway. Pharyngeal stenosisLLTMedDRA10050028 Pharyngeal stenosisPTCTCAE C78555 E13476 Pharyngeal stenosis Pharyngitis 10034835 NCIA disorder characterized by inflammation of the throat. Acute laryngopharyngitisLLTMedDRA10000826 Acute pharyngitisLLTMedDRA10001002 Chronic pharyngitisLLTMedDRA10009105 Laryngopharyngitis NOSLLTMedDRA10023887 LaryngopharyngitisLLTMedDRA10061264 OropharyngitisLLTMedDRA10057289 Pharyngitis (excl tonsillitis)LLTMedDRA10034836 Pharyngitis NOSLLTMedDRA10034838 Pharyngitis ulcerativeLLTMedDRA10057542 PharyngitisLLTMedDRA10034835 PharyngitisPTCTCAE Throat infectionLLTMedDRA10043520 C26851 E11525 Pharyngitis Pharyngolaryngeal pain 10034844 NCIA disorder characterized by marked discomfort sensation in the pharyngolaryngeal region. Chronic sore throatLLTMedDRA10066666 Laryngeal painLLTMedDRA10023848 Larynx burning pain ofLLTMedDRA10023899 Larynx painLLTMedDRA10023922 Oropharyngeal painLLTMedDRA10068319 Pain pharynxLLTMedDRA10033481 Pain throatLLTMedDRA10033494 Pharyngolaryngeal painLLTMedDRA10034844 Pharyngolaryngeal painPTCTCAE Sore throat NOSLLTMedDRA10041368 Sore throatLLTMedDRA10041367 Throat painLLTMedDRA10043523 Throat soreLLTMedDRA10043524 C78556 E13482 Pharyngolaryngeal pain Phlebitis 10034879 NCIA disorder characterized by inflammation of the wall of a vein. Chemical phlebitisLLTMedDRA10067560 Mechanical phlebitisLLTMedDRA10067562 Phlebitis (following medical procedure)LLTMedDRA10034880 Phlebitis NOSLLTMedDRA10034899 Phlebitis armLLTMedDRA10048449 Phlebitis lower limbLLTMedDRA10051996 PhlebitisLLTMedDRA10034879 PhlebitisPTCTCAE Postphlebitic limbLLTMedDRA10036301 C38003 E13815 Phlebitis Phlebitis infective 10056627 NCIA disorder characterized by an infectious process involving the vein. Clinical manifestations include erythema, marked discomfort, swelling, and induration along the course of the infected vein. Phlebitis infectiveLLTMedDRA10056627 Phlebitis infectivePTCTCAE C78558 E11530 Phlebitis infective Photophobia 10034960 NCIA disorder characterized by fear and avoidance of light. Exacerbation of photophobiaLLTMedDRA10015580 Eyes sensitive to sunlightLLTMedDRA10016011 Light sensitivity to eyeLLTMedDRA10065946 Photophobia aggravatedLLTMedDRA10034961 PhotophobiaLLTMedDRA10034960 PhotophobiaPTCTCAE C28210 E10416 Photophobia Photosensitivity 10034966 NCIA disorder characterized by an increase in sensitivity of the skin to light. Acute dermatitis due to solar radiationLLTMedDRA10000705 Dermatitis of exposed siteLLTMedDRA10012482 Dermatitis photosensitiveLLTMedDRA10012485 Eruption of exposed siteLLTMedDRA10015142 Exogenous photosensitive eruptionLLTMedDRA10015676 Heliosensitive rashLLTMedDRA10019378 Photocontact dermatitisLLTMedDRA10057057 Photosensitive dermatitisLLTMedDRA10034963 Photosensitive rashLLTMedDRA10034964 Photosensitive reactionLLTMedDRA10034965 Photosensitivity reaction NOSLLTMedDRA10034973 Photosensitivity reactionLLTMedDRA10034972 Photosensitivity toxic reactionLLTMedDRA10034974 PhotosensitivityLLTMedDRA10034966 PhotosensitivityPTCTCAE PhotosensitizedLLTMedDRA10034975 PhototoxicityLLTMedDRA10034977 PhytophotodermatitisLLTMedDRA10064897 Rash photosensitivityLLTMedDRA10037883 Solar sensitivenessLLTMedDRA10041306 Sun blisterLLTMedDRA10042493 Sun sensitivityLLTMedDRA10042494 C38004 E13680 Photosensitivity Platelet count decreased 10035528 NCIA finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen. Platelet count decreasedPTCTCAE C3408 E12207 Platelet count decreased Pleural effusion 10035598 NCIA disorder characterized by an increase in amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough and marked chest discomfort. Effusion pleuralLLTMedDRA10014313 Intrapleural fluid retention ofLLTMedDRA10022811 Pleural effusion recurrentLLTMedDRA10066721 Pleural effusionLLTMedDRA10035598 Pleural effusionPTCTCAE Pleural fluid exudateLLTMedDRA10059934 Pulmonary effusionLLTMedDRA10064889 Trapped lungLLTMedDRA10067976 Unspecified pleural effusionLLTMedDRA10046099 C3331 E13486 Pleural effusion Pleural hemorrhage 10055319 NCIA disorder characterized by bleeding from the pleural cavity. Haemorrhage pleuralLLTMedDRA10055837 Hemorrhage pleuralLLTMedDRA10019578 Pleural haemorrhageLLTMedDRA10035601 Pleural hemorrhageLLTMedDRA10055319 Pleural hemorrhagePTCTCAE C50582 E13492 Pleural hemorrhage Pleural infection 10061351 NCIA disorder characterized by an infectious process involving the pleura. Pleural infection NOSLLTMedDRA10051167 Pleural infectionLLTMedDRA10061351 Pleural infectionPTCTCAE C78563 E11535 Pleural infection Pleuritic pain 10035623 NCIA disorder characterized by marked discomfort sensation in the pleura. Pain pleuralLLTMedDRA10033482 Pleural painLLTMedDRA10035613 Pleuritic painLLTMedDRA10035623 Pleuritic painPTCTCAE PleurodyniaLLTMedDRA10035626 C78564 E13498 Pleuritic pain Pneumonitis 10035742 NCIA disorder characterized by inflammation focally or diffusely affecting the lung parenchyma. Pneumonitis NOSLLTMedDRA10035755 PneumonitisLLTMedDRA10035742 PneumonitisPTCTCAE PulmonitisLLTMedDRA10059809 C3333 E13502 Pneumonitis Pneumothorax 10035759 NCIA disorder characterized by abnormal presence of air in the pleural cavity resulting in the collapse of the lung. Iatrogenic pneumothoraxLLTMedDRA10021181 Pneumothorax (excl traumatic)LLTMedDRA10035760 Pneumothorax NOSLLTMedDRA10035762 Pneumothorax spontaneousLLTMedDRA10035763 PneumothoraxLLTMedDRA10035759 PneumothoraxPTCTCAE Tension pneumothoraxLLTMedDRA10043274 C38006 E13508 Pneumothorax Portal hypertension 10036200 NCIA disorder characterized by an increase in blood pressure in the portal venous system. Hypertension portalLLTMedDRA10020786 Portal hypertensionLLTMedDRA10036200 Portal hypertensionPTCTCAE Prehepatic portal hypertensionLLTMedDRA10057058 C3119 E11238 Portal hypertension Portal vein thrombosis 10036206 NCIA disorder characterized by the formation of a thrombus (blood clot) in the portal vein. Portal vein thrombosisLLTMedDRA10036206 Portal vein thrombosisPTCTCAE PylethrombosisLLTMedDRA10037611 Thrombosis portal veinLLTMedDRA10043633 C78565 E11243 Portal vein thrombosis Postnasal drip 10036402 NCIA disorder characterized by excessive mucous secretion in the back of the nasal cavity or throat, causing sore throat and/or coughing. Chronic post nasal dripLLTMedDRA10066649 Posterior nasal dripLLTMedDRA10036360 Postnasal dripLLTMedDRA10036402 Postnasal dripPTCTCAE C78566 E13514 Postnasal drip Postoperative hemorrhage 10055322 NCIA finding of bleeding occurring after a surgical procedure. Bleeding after stem cell transplantationLLTMedDRA10056503 Bleeding of suture siteLLTMedDRA10005125 Bleeding postoperativeLLTMedDRA10005127 Intestinal stoma site bleedingLLTMedDRA10049468 Post biopsy bleedingLLTMedDRA10054113 Post procedural bleedingLLTMedDRA10051014 Post procedural haemorrhageLLTMedDRA10051077 Post procedural hemorrhageLLTMedDRA10055320 Postoperative bleedingLLTMedDRA10036277 Postoperative haemorrhageLLTMedDRA10054709 Postoperative hemorrhageLLTMedDRA10055322 Postoperative hemorrhagePTCTCAE Stoma site bleedingLLTMedDRA10059020 Tracheostomy site bleedingLLTMedDRA10065749 Urostomy site bleedingLLTMedDRA10065748 C34938 E11903 Postoperative hemorrhage Postoperative thoracic procedure complication 10056745 NCIA finding of a previously undocumented problem that occurs after a thoracic procedure. Postoperative thoracic procedure complicationLLTMedDRA10056745 Postoperative thoracic procedure complicationPTCTCAE Sternal dehiscenceLLTMedDRA10064114 Unstable sternum, postoperativeLLTMedDRA10056750 C78567 E11909 Postoperative thoracic procedure complication Precocious puberty 10058084 NCIA disorder characterized by unusually early development of secondary sexual features; the onset of sexual maturation begins usually before age 8 for girls and before age 9 for boys. Accelerated sexual maturationLLTMedDRA10000359 Accelerated sexual maturityLLTMedDRA10000360 Early pubertyLLTMedDRA10014054 Female sex maturation acceleratedLLTMedDRA10016419 Male sex maturation acceleratedLLTMedDRA10025520 Maturation sex acceleratedLLTMedDRA10026944 Precocious puberty NOSLLTMedDRA10036520 Precocious pubertyLLTMedDRA10058084 Precocious pubertyPTCTCAE Premature adrenarcheLLTMedDRA10036589 Premature pubarcheLLTMedDRA10058089 Premature thelarcheLLTMedDRA10036612 Puberty precociousLLTMedDRA10037282 Sex maturation female acceleratedLLTMedDRA10040459 Sex maturation male acceleratedLLTMedDRA10040460 C79704 E10340 Precocious puberty Pregnancy, puerperium and perinatal conditions 10036585 Pregnancy, puerperium and perinatal conditionsPTCTCAE E13850 Pregnancy, puerperium and perinatal conditions Pregnancy, puerperium and perinatal conditions - Other, specify Pregnancy, puerperium and perinatal conditions - Other, specifyPTCTCAE E12861 Pregnancy, puerperium and perinatal conditions - Other, specify Premature delivery 10036595 NCIA disorder characterized by delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation. Early onset of delivery, unspecified as to episode of careLLTMedDRA10014051 Early onset of deliveryLLTMedDRA10014049 Labor prematureLLTMedDRA10023545 Labour prematureLLTMedDRA10023555 Premature deliveryLLTMedDRA10036595 Premature deliveryPTCTCAE Premature laborLLTMedDRA10036599 Premature labourLLTMedDRA10036600 Premature uterine contractionsLLTMedDRA10068718 C50917 E12867 Premature delivery Premature menopause 10036601 NCIA disorder characterized by ovarian failure before the age of 40. Symptoms include hot flashes, night sweats, mood swings and a decrease in sex drive. Climacterium praecoxLLTMedDRA10066271 Early menopauseLLTMedDRA10014045 Menopause prematureLLTMedDRA10027312 Premature menopauseLLTMedDRA10036601 Premature menopausePTCTCAE Premature ovarian failureLLTMedDRA10036602 C80099 E13179 Premature menopause Presyncope 10036653 NCIA disorder characterized by an episode of lightheadedness and dizziness which may precede an episode of syncope. Near faintingLLTMedDRA10066202 Near syncopeLLTMedDRA10066203 Orthostatic presyncopeLLTMedDRA10052495 Pre-syncopeLLTMedDRA10036507 PresyncopeLLTMedDRA10036653 PresyncopePTCTCAE Vagal reactionLLTMedDRA10046869 Vaso vagal attackLLTMedDRA10047138 Vasovagal attackLLTMedDRA10047165 Vasovagal reactionLLTMedDRA10047166 Vasovagal symptomsLLTMedDRA10047167 C80100 E12778 Presyncope Proctitis 10036774 NCIA disorder characterized by inflammation of the rectum. Acute proctitisLLTMedDRA10001018 Chronic proctitisLLTMedDRA10009108 Proctitis NOSLLTMedDRA10036782 ProctitisLLTMedDRA10036774 ProctitisPTCTCAE Rectal inflammatory processLLTMedDRA10038066 Rectal mucositisLLTMedDRA10063190 C38011 E10943 Proctitis Productive cough 10036790 NCIA disorder characterized by expectorated secretions upon coughing. ExpectorationLLTMedDRA10058996 Productive coughLLTMedDRA10036790 Productive coughPTCTCAE Sputum excretion increasedLLTMedDRA10041809 Sputum increasedLLTMedDRA10041812 SputumLLTMedDRA10041802 C78569 E13517 Productive cough Prolapse of intestinal stoma 10065745 NCIA finding of protrusion of the intestinal stoma (surgically created opening on the surface of the body) above the abdominal surface. Colostomy malfunctionLLTMedDRA10010047 Colostomy prolapseLLTMedDRA10058044 Continent ileostomy complicationLLTMedDRA10058932 Gastrointestinal stoma complicationLLTMedDRA10065718 Gastrointestinal stoma necrosisLLTMedDRA10065712 Ileostomy malfunctionLLTMedDRA10021324 Ileostomy overactiveLLTMedDRA10021326 Ileostomy underactiveLLTMedDRA10059093 Intestinal stoma complicationLLTMedDRA10059060 Intestinal stoma leakLLTMedDRA10059095 Intestinal stoma obstructionLLTMedDRA10059094 Jejunostomy malfunctionLLTMedDRA10052091 Obstructed colostomyLLTMedDRA10059092 Obstructed ileostomyLLTMedDRA10059091 Other complication of colostomy or enterostomyLLTMedDRA10031765 Overactive ileostomyLLTMedDRA10033290 Prolapse of intestinal stomaLLTMedDRA10065745 Prolapse of intestinal stomaPTCTCAE Stenosis of gastrointestinal stomaLLTMedDRA10065898 Stomal nipple complicationLLTMedDRA10058933 Unspecified complication of colostomy and enterostomyLLTMedDRA10045671 C78570 E11914 Prolapse of intestinal stoma Prolapse of urostomy 10065822 NCIA finding of displacement of the urostomy. Prolapse of urostomyLLTMedDRA10065822 Prolapse of urostomyPTCTCAE Urostomy complicationLLTMedDRA10065816 Urostomy leakLLTMedDRA10065882 Urostomy obstructionLLTMedDRA10065883 Urostomy perforationLLTMedDRA10065884 Urostomy stenosisLLTMedDRA10065885 C78571 E11920 Prolapse of urostomy Prostate infection 10050662 NCIA disorder characterized by an infectious process involving the prostate gland. Prostate infectionLLTMedDRA10050662 Prostate infectionPTCTCAE C27615 E11540 Prostate infection Prostatic hemorrhage 10055325 NCIA disorder characterized by bleeding from the prostate gland. Prostatic haemorrhageLLTMedDRA10036960 Prostatic hemorrhageLLTMedDRA10055325 Prostatic hemorrhagePTCTCAE C78572 E13181 Prostatic hemorrhage Prostatic obstruction 10055026 NCIA disorder characterized by compression of the urethra secondary to enlargement of the prostate gland. This results in voiding difficulties (straining to void, slow urine stream, and incomplete emptying of the bladder). Prostatic obstructionLLTMedDRA10055026 Prostatic obstructionPTCTCAE C78573 E13187 Prostatic obstruction Prostatic pain 10036968 NCIA disorder characterized by a sensation of marked discomfort in the prostate gland. Pain prostaticLLTMedDRA10033485 Prostatic painLLTMedDRA10036968 Prostatic painPTCTCAE ProstatodyniaLLTMedDRA10051490 C78574 E13191 Prostatic pain Proteinuria 10037032 NCIA disorder characterized by laboratory test results that indicate the presence of excessive protein in the urine. It is predominantly albumin, but also globulin. Proteinuria aggravatedLLTMedDRA10048433 ProteinuriaLLTMedDRA10037032 ProteinuriaPTCTCAE C38012 E13008 Proteinuria Pruritus 10037087 NCIA disorder characterized by an intense itching sensation. Extremities itchy sensation ofLLTMedDRA10015886 Hairy skin itchingLLTMedDRA10052416 Itch burningLLTMedDRA10023083 ItchLLTMedDRA10023082 Itching both handsLLTMedDRA10023087 ItchingLLTMedDRA10023084 Itchy legsLLTMedDRA10023091 Itchy scalpLLTMedDRA10023093 Itchy skinLLTMedDRA10023094 ItchyLLTMedDRA10023089 Localised itchingLLTMedDRA10058732 Localized itchingLLTMedDRA10058733 PruritisLLTMedDRA10037086 Pruritus NOSLLTMedDRA10037096 Pruritus aggravatedLLTMedDRA10048308 Pruritus breastLLTMedDRA10050817 Pruritus cutaneousLLTMedDRA10037090 Pruritus facialLLTMedDRA10037091 Pruritus of both handsLLTMedDRA10037097 PruritusLLTMedDRA10037087 PruritusPTCTCAE Unspecified pruritic disorderLLTMedDRA10046119 C3344 E13686 Pruritus Psychiatric disorders 10037175 Psychiatric disordersPTCTCAE E13867 Psychiatric disorders Psychiatric disorders - Other, specify Psychiatric disorders - Other, specifyPTCTCAE E12948 Psychiatric disorders - Other, specify Psychosis 10037234 NCIA disorder characterized by personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor. Atypical psychosisLLTMedDRA10059419 Chronic psychosisLLTMedDRA10066731 Drug psychoses, otherLLTMedDRA10013740 Drug psychosis, unspecifiedLLTMedDRA10013741 Drug-induced psychosisLLTMedDRA10013708 Psychosis NOSLLTMedDRA10037241 Psychosis aggravatedLLTMedDRA10048343 PsychosisLLTMedDRA10037234 PsychosisPTCTCAE Psychotic disorder NOSLLTMedDRA10037253 Psychotic disorderLLTMedDRA10061920 Psychotic episodeLLTMedDRA10037254 Psychotic reaction NOSLLTMedDRA10037256 Psychotic stateLLTMedDRA10037259 PsychoticLLTMedDRA10037248 Steroid psychosisLLTMedDRA10068305 Unspecified drug psychosisLLTMedDRA10045855 Unspecified psychosisLLTMedDRA10046122 C78576 E12954 Psychosis Pulmonary edema 10037375 NCIA disorder characterized by accumulation of fluid in the lung tissues that causes a disturbance of the gas exchange that may lead to respiratory failure. Edema lungLLTMedDRA10014233 Edema pulmonaryLLTMedDRA10014253 Lung edemaLLTMedDRA10025084 Lung oedemaLLTMedDRA10025112 Oedema lungLLTMedDRA10055929 Oedema pulmonaryLLTMedDRA10030126 Pulmonary edema aggravatedLLTMedDRA10054586 Pulmonary edema recurrentLLTMedDRA10066734 Pulmonary edemaLLTMedDRA10037375 Pulmonary edemaPTCTCAE Pulmonary oedema NOSLLTMedDRA10037426 Pulmonary oedema aggravatedLLTMedDRA10048429 Pulmonary oedema recurrentLLTMedDRA10066735 Pulmonary oedemaLLTMedDRA10037423 Subacute pulmonary edemaLLTMedDRA10066736 Subacute pulmonary oedemaLLTMedDRA10066737 C26868 E13521 Pulmonary edema Pulmonary fibrosis 10037383 NCIA disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure or right heart failure. Fibrosis lungLLTMedDRA10016649 Fibrosis pulmonaryLLTMedDRA10016660 Lung fibrosisLLTMedDRA10025088 Post inflammatory pulmonary fibrosisLLTMedDRA10057237 Pulmonary fibrosis (post inflammatory)LLTMedDRA10037384 Pulmonary fibrosisLLTMedDRA10037383 Pulmonary fibrosisPTCTCAE Pulmonary sclerosisLLTMedDRA10037431 C26869 E13527 Pulmonary fibrosis Pulmonary fistula 10065873 NCIA disorder characterized by an abnormal communication between the lung and another organ or anatomic site. Pulmonary fistulaLLTMedDRA10065873 Pulmonary fistulaPTCTCAE C78577 E13533 Pulmonary fistula Pulmonary hypertension 10037400 NCIA disorder characterized by an increase in pressure within the pulmonary circulation due to lung or heart disorder. CTEPHLLTMedDRA10068740 Chronic thromboembolic pulmonary hypertensionLLTMedDRA10068739 Hypertension pulmonary aggravatedLLTMedDRA10048383 Hypertension pulmonaryLLTMedDRA10020787 Pulmonary hypertension NOS aggravatedLLTMedDRA10037404 Pulmonary hypertension NOSLLTMedDRA10037403 Pulmonary hypertension aggravatedLLTMedDRA10037402 Pulmonary hypertension secondaryLLTMedDRA10037406 Pulmonary hypertensionLLTMedDRA10037400 Pulmonary hypertensionPTCTCAE C3120 E13539 Pulmonary hypertension Pulmonary valve disease 10061541 NCIA disorder characterized by a defect in pulmonary valve function or structure. Pulmonary valve disease NOSLLTMedDRA10037446 Pulmonary valve diseaseLLTMedDRA10061541 Pulmonary valve diseasePTCTCAE Pulmonary valve disordersLLTMedDRA10037447 Rheumatic diseases of pulmonary valveLLTMedDRA10039053 C78579 E10186 Pulmonary valve disease Purpura 10037549 NCIA disorder characterized by hemorrhagic areas of the skin and mucous membrane. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color. Dermatitis haemorrhagicLLTMedDRA10012466 Dermatitis hemorrhagicLLTMedDRA10012467 Haemolytic type rashLLTMedDRA10018931 Haemorrhage purpuricLLTMedDRA10018996 Hemolytic type rashLLTMedDRA10060610 Hemorrhage purpuricLLTMedDRA10055272 Idiopathic purpuraLLTMedDRA10021243 Purpura NOSLLTMedDRA10037559 Purpura symptomaticaLLTMedDRA10051289 PurpuraLLTMedDRA10037549 PurpuraPTCTCAE Purpuric rashLLTMedDRA10037566 Rash haemorrhagicLLTMedDRA10037859 Rash hemorrhagicLLTMedDRA10037860 Rash purpuricLLTMedDRA10037887 C78787 E13690 Purpura Pyramidal tract syndrome 10063636 NCIA disorder characterized by dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include an increase in the muscle tone in the lower extremities, hyperreflexia, positive Babinski and a decrease in fine motor coordination. Pyramidal tract lesionLLTMedDRA10037659 Pyramidal tract syndromeLLTMedDRA10063636 Pyramidal tract syndromePTCTCAE C43245 E12780 Pyramidal tract syndrome Radiation recall reaction (dermatologic) 10037767 NCIA finding of acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, for weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmaceutical agent. Radiation recall reaction (dermatologic)LLTMedDRA10037767 Radiation recall reaction (dermatologic)PTCTCAE Radiation recall syndromeLLTMedDRA10037768 Recall phenomenonLLTMedDRA10060856 C78580 E11926 Radiation recall reaction (dermatologic) Radiculitis 10061928 NCIA disorder characterized by inflammation involving a nerve root. Patients experience marked discomfort radiating along a nerve path because of spinal pressure on the connecting nerve root. Radiculitis NOSLLTMedDRA10048787 RadiculitisLLTMedDRA10061928 RadiculitisPTCTCAE Spinal funiculitisLLTMedDRA10064506 C78581 E12786 Radiculitis Rash acneiform 10037847 NCIA disorder characterized by an eruption of papules and pustules, typically appearing in face, scalp, upper chest and back. Acneiform dermatitisLLTMedDRA10000520 Acneiform eruptionLLTMedDRA10049843 Dermatitis acneiformLLTMedDRA10012432 Rash acneiformLLTMedDRA10037847 Rash acneiformPTCTCAE C35277 E13694 Rash acneiform Rash maculo-papular 10037868 NCIA disorder characterized by the presence of macules (flat) and papules (elevated). Also known as morbillform rash, it is one of the most common cutaneous adverse events, frequently affecting the upper trunk, spreading centripetally and associated with pruritus. Generalised raised red spots limbsLLTMedDRA10018093 Generalised raised red spots trunkLLTMedDRA10018094 Generalized raised red spots limbsLLTMedDRA10062442 Generalized raised red spots trunkLLTMedDRA10062443 Maculo-papular exanthemaLLTMedDRA10049195 Maculo-papular rashLLTMedDRA10025423 Maculo-papularLLTMedDRA10025422 Maculopapular rashLLTMedDRA10025424 Papular rash circumocular-blepharalLLTMedDRA10033727 Rash maculo-papularLLTMedDRA10037868 Rash maculo-papularPTCTCAE C75579 E13700 Rash maculo-papular Rash pustular 10037888 NCIA disorder characterized by a circumscribed and elevated skin lesion filled with pus. Papulopustular rashLLTMedDRA10069138 Pustular rashLLTMedDRA10037576 Pustular skin eruptionLLTMedDRA10037577 PustuleLLTMedDRA10037578 Pustules on handLLTMedDRA10037579 Rash pustularLLTMedDRA10037888 Rash pustularPTCTCAE Rash vesiculo-pustularLLTMedDRA10037900 Rash vesiculopustularLLTMedDRA10037902 Vesiculo-pustular rashLLTMedDRA10047380 Vesiculopustular rashLLTMedDRA10047382 C80119 E11545 Rash pustular Rectal anastomotic leak 10065894 NCIA finding of leakage due to breakdown of a rectal anastomosis (surgical connection of two separate anatomic structures). Esophageal anastomotic leakLLTMedDRA10065961 Gastric anastomotic leakLLTMedDRA10065893 Gastrointestinal anastomotic leakLLTMedDRA10065879 Intestinal anastomotic leakLLTMedDRA10054119 Large intestinal anastomotic leakLLTMedDRA10065891 Oesophageal anastomotic leakLLTMedDRA10065890 Rectal anastomotic leakLLTMedDRA10065894 Rectal anastomotic leakPTCTCAE Small intestinal anastomotic leakLLTMedDRA10065892 C78583 E11932 Rectal anastomotic leak Rectal fistula 10038062 NCIA disorder characterized by an abnormal communication between the rectum and another organ or anatomic site. Anal fistulaLLTMedDRA10002156 Anorectal fistulaLLTMedDRA10002645 Fistula analLLTMedDRA10016718 Fistula in anoLLTMedDRA10016721 Perianal fistulaLLTMedDRA10068659 Rectal fistulaLLTMedDRA10038062 Rectal fistulaPTCTCAE Rectum to skin fistulaLLTMedDRA10038102 C79713 E10949 Rectal fistula Rectal hemorrhage 10038064 NCIA disorder characterized by bleeding from the rectal wall and discharged from the anus. Bleeding PR (excl gut haemorrhage and piles)LLTMedDRA10005129 Bleeding PR (excl gut hemorrhage & piles)LLTMedDRA10055232 Bleeding rectalLLTMedDRA10005131 Haemorrhage from rectum (excl intestinal/piles)LLTMedDRA10018975 Haemorrhage rectalLLTMedDRA10055842 Haemorrhage rectumLLTMedDRA10018997 Hemorrhage from rectum (excl intestinal/piles)LLTMedDRA10055676 Hemorrhage rectalLLTMedDRA10019583 Hemorrhage rectumLLTMedDRA10055273 ProctorrhagiaLLTMedDRA10063132 Rectal bleeding (excl gut haemorrhage and piles)LLTMedDRA10038036 Rectal bleeding (excl gut hemorrhage and piles)LLTMedDRA10055327 Rectal bleedingLLTMedDRA10038035 Rectal blood lossLLTMedDRA10038037 Rectal haemorrhageLLTMedDRA10038063 Rectal hemorrhageLLTMedDRA10038064 Rectal hemorrhagePTCTCAE RectorrhagiaLLTMedDRA10063014 C27054 E10955 Rectal hemorrhage Rectal mucositis 10063190 NCIA disorder characterized by inflammation of the mucous membrane of the rectum. Acute proctitisLLTMedDRA10001018 Chronic proctitisLLTMedDRA10009108 Proctitis NOSLLTMedDRA10036782 ProctitisLLTMedDRA10036774 Rectal inflammatory processLLTMedDRA10038066 Rectal mucositisLLTMedDRA10063190 Rectal mucositisPTCTCAE C78584 E10961 Rectal mucositis Rectal necrosis 10065709 NCIA disorder characterized by a necrotic process occurring in the rectal wall. Anal necrosisLLTMedDRA10065722 Duodenal necrosisLLTMedDRA10065725 Esophageal necrosisLLTMedDRA10065727 Gastric necrosisLLTMedDRA10051886 Gastrointestinal necrosisLLTMedDRA10017982 Ileal necrosisLLTMedDRA10065729 Intestinal necrosisLLTMedDRA10022686 Jejunal necrosisLLTMedDRA10065731 Necrosis bowelLLTMedDRA10028856 Necrosis intestinalLLTMedDRA10028861 Oesophageal necrosisLLTMedDRA10065737 Rectal necrosisLLTMedDRA10065709 Rectal necrosisPTCTCAE Small intestinal necrosisLLTMedDRA10065711 C78585 E10967 Rectal necrosis Rectal obstruction 10065707 NCIA disorder characterized by blockage of the normal flow of the intestinal contents in the rectum. Rectal obstructionLLTMedDRA10065707 Rectal obstructionPTCTCAE C78586 E10971 Rectal obstruction Rectal pain 10038072 NCIA disorder characterized by a sensation of marked discomfort in the rectal region. Anal painLLTMedDRA10002167 Anorectal painLLTMedDRA10058446 Anus painLLTMedDRA10002854 Pain analLLTMedDRA10033377 Pain rectalLLTMedDRA10033486 Perianal painLLTMedDRA10067119 ProctalgiaLLTMedDRA10036772 Rectal painLLTMedDRA10038072 Rectal painPTCTCAE C78587 E10977 Rectal pain Rectal perforation 10038073 NCIA disorder characterized by a rupture in the rectal wall. Rectal perforationLLTMedDRA10038073 Rectal perforationPTCTCAE C78588 E10981 Rectal perforation Rectal stenosis 10038079 NCIA disorder characterized by a narrowing of the lumen of the rectum. Rectal stenosisLLTMedDRA10038079 Rectal stenosisPTCTCAE C78589 E10986 Rectal stenosis Rectal ulcer 10038080 NCIA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the rectum. Rectal ulcerLLTMedDRA10038080 Rectal ulcerPTCTCAE Solitary rectal ulcerLLTMedDRA10041312 Solitary ulcer of rectum (sphincter)LLTMedDRA10041314 Stercoral ulcer of rectum (sphincter)LLTMedDRA10042002 Ulcer rectalLLTMedDRA10045333 C78590 E10992 Rectal ulcer Recurrent laryngeal nerve palsy 10038130 NCIA disorder characterized by paralysis of the recurrent laryngeal nerve. Bilateral complete paralysis of vocal cordsLLTMedDRA10004559 LaryngoparalysisLLTMedDRA10023886 Paralysis recurrent laryngeal nerveLLTMedDRA10033830 Paralysis vocal cordLLTMedDRA10033836 Recurrent laryngeal nerve palsyLLTMedDRA10038130 Recurrent laryngeal nerve palsyPTCTCAE Unilateral complete paralysis of vocal cordsLLTMedDRA10045529 Unspecified paralysis of vocal cordsLLTMedDRA10046089 Vocal cord paralysisLLTMedDRA10047674 C78592 E12792 Recurrent laryngeal nerve palsy Renal and urinary disorders 10038359 Renal and urinary disordersPTCTCAE E13861 Renal and urinary disorders Renal and urinary disorders - Other, specify Renal and urinary disorders - Other, specifyPTCTCAE E13012 Renal and urinary disorders - Other, specify Renal calculi 10038385 NCIA disorder characterized by the formation of crystals in the pelvis of the kidney. Renal calculiPTCTCAE C26807 E13018 Renal calculi Renal colic 10038419 NCIA disorder characterized by paroxysmal and severe flank marked discomfort radiating to the inguinal area. Often, the cause is the passage of kidney stones. Colic renalLLTMedDRA10009885 Pain ureteralLLTMedDRA10033497 Renal colicLLTMedDRA10038419 Renal colicPTCTCAE Ureteral painLLTMedDRA10046387 Ureteric colicLLTMedDRA10046398 C78593 E13024 Renal colic Renal hemorrhage 10038463 NCIA disorder characterized by bleeding from the kidney. Haemorrhage kidneyLLTMedDRA10055820 Hemorrhage kidneyLLTMedDRA10019557 Renal cyst haemorrhageLLTMedDRA10059846 Renal cyst hemorrhageLLTMedDRA10059847 Renal haemorrhageLLTMedDRA10038460 Renal hemorrhageLLTMedDRA10038463 Renal hemorrhagePTCTCAE Renal parenchymal haemorrhageLLTMedDRA10038495 Renal parenchymal hemorrhageLLTMedDRA10038496 C78594 E13028 Renal hemorrhage Reproductive system and breast disorders 10038604 Reproductive system and breast disordersPTCTCAE E13851 Reproductive system and breast disorders Reproductive system and breast disorders - Other, specify Reproductive system and breast disorders - Other, specifyPTCTCAE E13195 Reproductive system and breast disorders - Other, specify Respiratory failure 10038695 NCIA disorder characterized by impaired gas exchange by the respiratory system resulting in hypoxemia and a decrease in oxygenation of the tissues that may be associated with an increase in arterial levels of carbon dioxide. Failure respiratoryLLTMedDRA10016162 Hypercapnic respiratory failureLLTMedDRA10060842 Pulmonary failureLLTMedDRA10051995 Respiration failureLLTMedDRA10038651 Respiratory failure aggravatedLLTMedDRA10068615 Respiratory failureLLTMedDRA10038695 Respiratory failurePTCTCAE Respiratory insufficiencyLLTMedDRA10038701 Restrictive respiratory insufficiencyLLTMedDRA10064760 Ventilatory failureLLTMedDRA10047267 C26872 E13545 Respiratory failure Respiratory, thoracic and mediastinal disorders 10038738 Respiratory, thoracic and mediastinal disordersPTCTCAE E13854 Respiratory, thoracic and mediastinal disorders Respiratory, thoracic and mediastinal disorders - Other, specify Respiratory, thoracic and mediastinal disorders - Other, specifyPTCTCAE E13548 Respiratory, thoracic and mediastinal disorders - Other, specify Restlessness 10038743 NCIA disorder characterized by an inability to rest, relax or be still. Marked restlessnessLLTMedDRA10026838 Muscular unrestLLTMedDRA10028370 Physical wanderingLLTMedDRA10034991 Physically restlessLLTMedDRA10034993 Psychomotor restlessnessLLTMedDRA10037212 RestlessLLTMedDRA10038740 Restlessness (drug related)LLTMedDRA10038744 Restlessness (phenothiazine)LLTMedDRA10038745 Restlessness aggravatedLLTMedDRA10048337 Restlessness markedLLTMedDRA10038746 RestlessnessLLTMedDRA10038743 RestlessnessPTCTCAE UnrestLLTMedDRA10045556 Wandering aroundLLTMedDRA10047816 WanderingLLTMedDRA10047815 C74533 E12960 Restlessness Restrictive cardiomyopathy 10038748 NCIA disorder characterized by an inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and loses its flexibility. Endomyocardial fibrosisLLTMedDRA10014800 Eosinophilic endomyocardial diseaseLLTMedDRA10014953 Obliterative cardiomyopathyLLTMedDRA10029890 Restrictive cardiomyopathyLLTMedDRA10038748 Restrictive cardiomyopathyPTCTCAE C62798 E10192 Restrictive cardiomyopathy Retinal detachment 10038848 NCIA disorder characterized by the separation of the inner retina layers from the underlying pigment epithelium. Amotio retinaeLLTMedDRA10064854 Detached retinaLLTMedDRA10012533 Detachment retinalLLTMedDRA10012542 Retinal detachmentLLTMedDRA10038848 Retinal detachmentPTCTCAE Retinal detachments and defects, unspecifiedLLTMedDRA10038852 Rhegmatogenous retinal detachmentLLTMedDRA10065569 Serous retinal detachmentLLTMedDRA10040114 Traction detachment of retinaLLTMedDRA10044331 Unspecified retinal detachmentLLTMedDRA10046144 Vitreoretinal detachmentLLTMedDRA10056685 C26874 E10420 Retinal detachment Retinal tear 10038897 NCIA disorder characterized by a small laceration of the retina, this occurs when the vitreous separates from the retina. Symptoms include flashes and floaters. Horseshoe tear of retina without detachmentLLTMedDRA10020394 Multiple defects of retina without detachmentLLTMedDRA10028187 Retinal breakLLTMedDRA10066422 Retinal holeLLTMedDRA10066423 Retinal tearLLTMedDRA10038897 Retinal tearPTCTCAE Round hole of retina without detachmentLLTMedDRA10039239 C50732 E10425 Retinal tear Retinal vascular disorder 10038901 NCIA disorder characterized by pathological retinal blood vessels that adversely affects vision. Retinal vascular disorderPTCTCAE C35170 E10429 Retinal vascular disorder Retinoic acid syndrome 10038921 NCIA disorder characterized by weight gain, dyspnea, pleural and pericardial effusions, leukocytosis and/or renal failure originally described in patients treated with all-trans retinoic acid. ATRA syndromeLLTMedDRA10066325 Retinoic acid syndromeLLTMedDRA10038921 Retinoic acid syndromePTCTCAE C78597 E13554 Retinoic acid syndrome Retinopathy 10038923 NCIA disorder involving the retina. Retinal AV nippingLLTMedDRA10038833 Retinal arterial nippingLLTMedDRA10038823 Retinal arteriovenous nickingLLTMedDRA10058007 Retinopathy NOSLLTMedDRA10048487 RetinopathyLLTMedDRA10038923 RetinopathyPTCTCAE Varying retinal vessel calibreLLTMedDRA10047035 C62601 E10432 Retinopathy Retroperitoneal hemorrhage 10038981 NCIA disorder characterized by bleeding from the retroperitoneal area. Haemorrhage retroperitonealLLTMedDRA10018998 Hemorrhage retroperitonealLLTMedDRA10019585 Retroperitoneal bleedLLTMedDRA10038976 Retroperitoneal haemorrhageLLTMedDRA10038980 Retroperitoneal hemorrhageLLTMedDRA10038981 Retroperitoneal hemorrhagePTCTCAE C26944 E10998 Retroperitoneal hemorrhage Reversible posterior leukoencephalopathy syndrome 10063761 NCIA disorder characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. It is an acute or subacute reversible condition. Reversible posterior leukoencephalopathy syndromeLLTMedDRA10063761 Reversible posterior leukoencephalopathy syndromePTCTCAE C78598 E12798 Reversible posterior leukoencephalopathy syndrome Rhinitis infective 10059827 NCIA disorder characterized by an infectious process involving the nasal mucosal. Acute rhinitisLLTMedDRA10066743 Chronic nonspecific rhinitisLLTMedDRA10009023 Chronic rhinitis (excl allergic)LLTMedDRA10009130 Chronic rhinitisLLTMedDRA10009129 CoryzaLLTMedDRA10011214 Coryzal symptomsLLTMedDRA10011216 Infective rhinitisLLTMedDRA10021921 Nose infection NOSLLTMedDRA10029799 Purulent nasal dischargeLLTMedDRA10056749 Purulent rhinorrheaLLTMedDRA10056752 Purulent rhinorrhoeaLLTMedDRA10056753 Redness of naresLLTMedDRA10038208 Rhinitis (infective)LLTMedDRA10039084 Rhinitis NOS exacerbatedLLTMedDRA10039093 Rhinitis NOSLLTMedDRA10039092 Rhinitis exacerbatedLLTMedDRA10039089 Rhinitis infectiveLLTMedDRA10059827 Rhinitis infectivePTCTCAE Rhinitis purulentLLTMedDRA10050088 RhinitisLLTMedDRA10039083 C78599 E11548 Rhinitis infective Right ventricular dysfunction 10058597 NCIA disorder characterized by impairment of right ventricular function associated with low ejection fraction and a decrease in motility of the right ventricular wall. Right ventricular dysfunctionLLTMedDRA10058597 Right ventricular dysfunctionPTCTCAE C50733 E10196 Right ventricular dysfunction Salivary duct inflammation 10056681 NCIA disorder characterized by inflammation of the salivary duct. Salivary duct inflammationLLTMedDRA10056681 Salivary duct inflammationPTCTCAE C78600 E11003 Salivary duct inflammation Salivary gland fistula 10039411 NCIA disorder characterized by an abnormal communication between a salivary gland and another organ or anatomic site. Fistula of salivary glandLLTMedDRA10016728 Salivary gland fistulaLLTMedDRA10039411 Salivary gland fistulaPTCTCAE C79715 E11009 Salivary gland fistula Salivary gland infection 10039413 NCIA disorder characterized by an infectious process involving the salivary gland. Purulent sialoadenitisLLTMedDRA10049611 Salivary gland infection (excl mumps)LLTMedDRA10039414 Salivary gland infectionLLTMedDRA10039413 Salivary gland infectionPTCTCAE SialadenitisLLTMedDRA10040627 Sialoadenitis NOSLLTMedDRA10040630 Sialoadenitis infectionLLTMedDRA10040629 SialoadenitisLLTMedDRA10040628 Submandibular adenitisLLTMedDRA10068199 C78601 E11550 Salivary gland infection Scalp pain 10049120 NCIA disorder characterized by marked discomfort sensation in the skin covering the top and the back of the head. Pain of skinLLTMedDRA10033474 Scalp painLLTMedDRA10049120 Scalp painPTCTCAE Scalp tendernessLLTMedDRA10039521 Skin tendernessLLTMedDRA10051797 Stinging skinLLTMedDRA10065061 C79716 E13704 Scalp pain Scleral disorder 10061510 NCIA disorder characterized by involvement of the sclera of the eye. Scleral disorder NOSLLTMedDRA10039697 Scleral disorderLLTMedDRA10061510 Scleral disorderPTCTCAE C79717 E10437 Scleral disorder Scoliosis 10039722 NCIA disorder characterized by a malformed, lateral curvature of the spine. Progressive infantile idiopathic scoliosisLLTMedDRA10036804 Resolving infantile idiopathic scoliosisLLTMedDRA10038640 RotoscoliosisLLTMedDRA10064654 ScoliosisLLTMedDRA10039722 ScoliosisPTCTCAE Thoracogenic scoliosisLLTMedDRA10043483 C78603 E12521 Scoliosis Scrotal infection 10062156 NCIA disorder characterized by an infectious process involving the scrotum. Scrotal infection NOSLLTMedDRA10039752 Scrotal infectionLLTMedDRA10062156 Scrotal infectionPTCTCAE C78606 E11555 Scrotal infection Scrotal pain 10039757 NCIA disorder characterized by marked discomfort sensation in the scrotal area. Scrotal painLLTMedDRA10039757 Scrotal painPTCTCAE C78607 E13201 Scrotal pain Seizure 10039906 NCIA disorder characterized by a sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin. Afebrile convulsionLLTMedDRA10001435 Afebrile seizureLLTMedDRA10001436 Classic fitLLTMedDRA10009234 Convulsion (excl neonatal)LLTMedDRA10010905 Convulsion disorderLLTMedDRA10010907 ConvulsionLLTMedDRA10010904 Convulsions NOS aggravatedLLTMedDRA10010923 Convulsions NOSLLTMedDRA10010922 Convulsions aggravatedLLTMedDRA10010915 Convulsions generalisedLLTMedDRA10010916 Convulsions generalizedLLTMedDRA10010917 ConvulsionsLLTMedDRA10010914 Convulsive disorderLLTMedDRA10010924 Convulsive movementsLLTMedDRA10010925 Convulsive seizureLLTMedDRA10010926 Disorder convulsiveLLTMedDRA10013208 Fit (non-epileptic)LLTMedDRA10016733 Generalised convulsionLLTMedDRA10018079 Seizure cerebralLLTMedDRA10039908 SeizureLLTMedDRA10039906 SeizurePTCTCAE Seizures cerebralLLTMedDRA10039913 SeizuresLLTMedDRA10039910 Tetany-like seizureLLTMedDRA10043382 C2962 E12804 Seizure Sepsis 10040047 NCIA disorder characterized by the presence of pathogenic microorganisms in the blood stream that cause a rapidly progressing systemic reaction that may lead to shock. PyaemiaLLTMedDRA10037583 PyemiaLLTMedDRA10037609 Sepsis NOSLLTMedDRA10040050 Sepsis secondaryLLTMedDRA10040053 SepsisLLTMedDRA10040047 SepsisPTCTCAE Septicaemia NOSLLTMedDRA10040082 SepticaemiaLLTMedDRA10040072 SepticemiaLLTMedDRA10040089 SepticopyaemiaLLTMedDRA10059291 SepticopyemiaLLTMedDRA10059281 Unspecified septicaemiaLLTMedDRA10060437 Unspecified septicemiaLLTMedDRA10046161 C3364 E11560 Sepsis Seroma 10040102 NCIA finding of tumor-like collection of serum in the tissues. Abdominal seromaLLTMedDRA10063047 Pelvic seromaLLTMedDRA10063046 SeromaLLTMedDRA10040102 SeromaPTCTCAE C50739 E11938 Seroma Serum amylase increased 10040139 NCIA finding based on laboratory test results that indicate an increase in the levels of amylase in a serum specimen. Amylase highLLTMedDRA10002015 Amylase increasedLLTMedDRA10002016 Amylase serum increasedLLTMedDRA10002018 Blood alpha amylase increasedLLTMedDRA10053909 Blood amylase increasedLLTMedDRA10005328 Blood gamma amylase increasedLLTMedDRA10053912 Blood pancreatic amylase increasedLLTMedDRA10053880 Blood salivary amylase increasedLLTMedDRA10058312 Plasma amylase increasedLLTMedDRA10035183 Serum amylase increasedLLTMedDRA10040139 Serum amylase increasedPTCTCAE C78608 E12212 Serum amylase increased Serum sickness 10040400 NCIA disorder characterized by a delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty-one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest marked discomfort and dyspnea. Reaction serum sickness-likeLLTMedDRA10037970 Serum reactionLLTMedDRA10040394 Serum sickness-like disorderLLTMedDRA10040401 Serum sicknessLLTMedDRA10040400 Serum sicknessPTCTCAE Serum-sickness like disorderLLTMedDRA10040439 C79718 E11276 Serum sickness Sick sinus syndrome 10040639 NCIA disorder characterized by a dysrhythmia with alternating periods of bradycardia and atrial tachycardia accompanied by syncope, fatigue and dizziness. Bradycardia-tachycardia syndromeLLTMedDRA10049203 BradytachycardiaLLTMedDRA10050109 Sick sinus syndromeLLTMedDRA10040639 Sick sinus syndromePTCTCAE Syndrome sick sinusLLTMedDRA10042845 C62244 E10202 Sick sinus syndrome Sinus bradycardia 10040741 NCIA disorder characterized by a dysrhythmia with a heart rate less than 60 beats per minute that originates in the sinus node. Bradycardia sinusLLTMedDRA10006098 Sinus bradycardiaLLTMedDRA10040741 Sinus bradycardiaPTCTCAE C26923 E10208 Sinus bradycardia Sinus disorder 10062244 NCIA disorder characterized by involvement of the paranasal sinuses. Sinus disorder NOSLLTMedDRA10051829 Sinus disorderLLTMedDRA10062244 Sinus disorderPTCTCAE C26843 E13560 Sinus disorder Sinus pain 10040747 NCIA disorder characterized by marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses. Headache sinusLLTMedDRA10019224 Sinus headacheLLTMedDRA10040744 Sinus painLLTMedDRA10040747 Sinus painPTCTCAE Sinus pressureLLTMedDRA10040751 C78609 E12810 Sinus pain Sinus tachycardia 10040752 NCIA disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates in the sinus node. Sinus tachycardiaLLTMedDRA10040752 Sinus tachycardiaPTCTCAE Tachycardia sinusLLTMedDRA10043083 C26889 E10214 Sinus tachycardia Sinusitis 10040753 NCIA disorder characterized by an infectious process involving the mucous membranes of the paranasal sinuses. Maxillary sinusitisLLTMedDRA10056475 PansinusitisLLTMedDRA10049682 Paranasal sinus infectionLLTMedDRA10065770 RhinosinusitisLLTMedDRA10052106 Sinus infectionLLTMedDRA10040745 Sinusitis NOSLLTMedDRA10040756 Sinusitis recurrentLLTMedDRA10066655 SinusitisLLTMedDRA10040753 SinusitisPTCTCAE C35024 E11563 Sinusitis Skin and subcutaneous tissue disorders 10040785 Skin and subcutaneous tissue disordersPTCTCAE E13853 Skin and subcutaneous tissue disorders Skin and subcutaneous tissue disorders - Other, specify Skin and subcutaneous tissue disorders - Other, specifyPTCTCAE E13708 Skin and subcutaneous tissue disorders - Other, specify Skin atrophy 10040799 NCIA disorder characterized by the degeneration and thinning of the epidermis and dermis. Atrophy skinLLTMedDRA10003719 Loss of skin elasticityLLTMedDRA10024875 Senile skin atrophyLLTMedDRA10039989 Skin atrophy senileLLTMedDRA10040800 Skin atrophyLLTMedDRA10040799 Skin atrophyPTCTCAE Skin thinnessLLTMedDRA10040937 Skin thinning ofLLTMedDRA10040938 C35163 E13714 Skin atrophy Skin hyperpigmentation 10040865 NCIA disorder characterized by darkening of the skin due to excessive melanin deposition. HypermelanosisLLTMedDRA10050574 Hyperpigmentation of eyelidLLTMedDRA10020714 Hyperpigmentation skinLLTMedDRA10020715 Skin hyperpigmentationLLTMedDRA10040865 Skin hyperpigmentationPTCTCAE C79731 E13718 Skin hyperpigmentation Skin hypopigmentation 10040868 NCIA disorder characterized by loss of skin pigment. HypomelanosisLLTMedDRA10050575 Hypopigmentation of eyelidLLTMedDRA10021065 Skin hypopigmentationLLTMedDRA10040868 Skin hypopigmentationPTCTCAE C78610 E13721 Skin hypopigmentation Skin induration 10051837 NCIA disorder characterized by an area of hardness in the skin. Skin indurationLLTMedDRA10051837 Skin indurationPTCTCAE C78611 E13724 Skin induration Skin infection 10040872 NCIA disorder characterized by an infectious process involving the skin. Exacerbation of infection of skinLLTMedDRA10015578 Infected scarLLTMedDRA10058023 Skin infection NOSLLTMedDRA10040874 Skin infection aggravatedLLTMedDRA10040873 Skin infectionLLTMedDRA10040872 Skin infectionPTCTCAE Subcutaneous infectionLLTMedDRA10067882 Unspecified local infection of skin and subcutaneous tissueLLTMedDRA10045995 C35025 E11568 Skin infection Skin ulceration 10040947 NCIA disorder characterized by circumscribed, inflammatory and necrotic erosive lesion on the skin. Ankle ulcerLLTMedDRA10048922 Chronic leg ulcerLLTMedDRA10066677 Chronic skin ulcer of unspecified siteLLTMedDRA10009144 Chronic skin ulcerLLTMedDRA10009142 Chronic ulcer of skin, other specified sitesLLTMedDRA10009156 Chronic ulcer of skin, unspecified siteLLTMedDRA10009157 Chronic ulcer of skinLLTMedDRA10009155 Foot ulcerLLTMedDRA10016980 Heel ulcerLLTMedDRA10049034 Ischaemic leg ulcerLLTMedDRA10023026 Ischemic leg ulcerLLTMedDRA10055219 Leg ulcer (excl varicose)LLTMedDRA10053157 Leg ulcerLLTMedDRA10068310 Lower extremities ulcers ofLLTMedDRA10024946 Multiple skin ulcersLLTMedDRA10067106 Skin trophic ulcerLLTMedDRA10059816 Skin ulcer NOSLLTMedDRA10040945 Skin ulcerLLTMedDRA10040943 Skin ulcerationLLTMedDRA10040947 Skin ulcerationPTCTCAE Stasis ulcerLLTMedDRA10041957 Ulcer footLLTMedDRA10045303 Ulcer of lower limbs, except decubitus ulcerLLTMedDRA10045326 Ulcer of lower limbs, excl decubitus ulcerLLTMedDRA10056803 Ulcer skinLLTMedDRA10045334 Ulcers of extremitiesLLTMedDRA10045373 Ulcus crurisLLTMedDRA10060790 Venous stasis ulcerLLTMedDRA10047246 Venous ulcer NOSLLTMedDRA10047259 Venous ulcer dischargeLLTMedDRA10054911 Venous ulcer odorLLTMedDRA10059103 Venous ulcer odourLLTMedDRA10059105 Venous ulcer recurrentLLTMedDRA10066683 Venous ulcerationLLTMedDRA10047260 C54247 E13730 Skin ulceration Sleep apnea 10040975 NCIA disorder characterized by cessation of breathing for short periods during sleep. Apnea syndromeLLTMedDRA10055575 Apnoea syndromeLLTMedDRA10053654 Central sleep apnea syndromeLLTMedDRA10055576 Central sleep apnoea syndromeLLTMedDRA10007975 Obstructive sleep apnea syndromeLLTMedDRA10055577 Obstructive sleep apnoea syndromeLLTMedDRA10029983 Sleep apnea syndromeLLTMedDRA10040976 Sleep apneaLLTMedDRA10040975 Sleep apneaPTCTCAE Sleep apnoea syndromeLLTMedDRA10040979 Sleep apnoea syndromesLLTMedDRA10040980 Sleep apnoeaLLTMedDRA10040977 C26884 E13566 Sleep apnea Small intestinal anastomotic leak 10065892 NCIA finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the small bowel. Esophageal anastomotic leakLLTMedDRA10065961 Gastric anastomotic leakLLTMedDRA10065893 Gastrointestinal anastomotic leakLLTMedDRA10065879 Intestinal anastomotic leakLLTMedDRA10054119 Large intestinal anastomotic leakLLTMedDRA10065891 Oesophageal anastomotic leakLLTMedDRA10065890 Rectal anastomotic leakLLTMedDRA10065894 Small intestinal anastomotic leakLLTMedDRA10065892 Small intestinal anastomotic leakPTCTCAE C78612 E11942 Small intestinal anastomotic leak Small intestinal mucositis 10065710 NCIA disorder characterized by inflammation of the mucous membrane of the small intestine. Gastroenteritis non-infectious NOSLLTMedDRA10017905 Gastroenteritis noninfectiousLLTMedDRA10061167 Gastrointestinal inflammationLLTMedDRA10064147 Gastrointestinal mucositisLLTMedDRA10017981 Intestinal hyperaemiaLLTMedDRA10067635 Intestinal hyperemiaLLTMedDRA10067630 Large intestinal mucositisLLTMedDRA10065733 Small intestinal mucositisLLTMedDRA10065710 Small intestinal mucositisPTCTCAE C78613 E11015 Small intestinal mucositis Small intestinal obstruction 10041101 NCIA disorder characterized by blockage of the normal flow of the intestinal contents. Ileal obstructionLLTMedDRA10065730 Jejunal obstructionLLTMedDRA10065732 Obstruction small intestineLLTMedDRA10029969 Partial small intestinal obstructionLLTMedDRA10056357 Small bowel obstructionLLTMedDRA10041055 Small intestinal obstruction NOSLLTMedDRA10041102 Small intestinal obstructionLLTMedDRA10041101 Small intestinal obstructionPTCTCAE Small intestine obstructionLLTMedDRA10041129 C78615 E11021 Small intestinal obstruction Small intestinal perforation 10041103 NCIA disorder characterized by a rupture in the small intestine wall. Intestinal perforation smallLLTMedDRA10022697 Perforation small intestineLLTMedDRA10034429 Small intestinal perforation NOSLLTMedDRA10041104 Small intestinal perforationLLTMedDRA10041103 Small intestinal perforationPTCTCAE Small intestinal ulcer perforationLLTMedDRA10052498 Small intestine perforationLLTMedDRA10041131 C78616 E11027 Small intestinal perforation Small intestinal stenosis 10062263 NCIA disorder characterized by a narrowing of the lumen of the small intestine. Small intestinal stenosis NOSLLTMedDRA10041106 Small intestinal stenosisLLTMedDRA10062263 Small intestinal stenosisPTCTCAE Small intestinal stricture NOSLLTMedDRA10041108 Small intestinal strictureLLTMedDRA10041107 Small intestine stenosisLLTMedDRA10041132 Stenosis small intestineLLTMedDRA10041996 C78617 E11032 Small intestinal stenosis Small intestine infection 10065771 NCIA disorder characterized by an infectious process involving the small intestine. Duodenal infectionLLTMedDRA10065752 Enteritis infectiousLLTMedDRA10058839 Ileal infectionLLTMedDRA10065753 Ill-defined intestinal infectionsLLTMedDRA10021354 Jejunal infectionLLTMedDRA10065754 Small intestine infectionLLTMedDRA10065771 Small intestine infectionPTCTCAE C78618 E11574 Small intestine infection Small intestine ulcer 10041133 NCIA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the small intestine. Small intestinal ulcer NOSLLTMedDRA10041109 Small intestine ulcerLLTMedDRA10041133 Small intestine ulcerPTCTCAE Ulcer small intestineLLTMedDRA10045335 C78619 E11038 Small intestine ulcer Sneezing 10041232 NCIA disorder characterized by the involuntary expulsion of air from the nose. Paroxysmal sneezeLLTMedDRA10034043 Sneezing excessiveLLTMedDRA10041233 SneezingLLTMedDRA10041232 SneezingPTCTCAE C50746 E13572 Sneezing Social circumstances 10041244 Social circumstancesPTCTCAE E13860 Social circumstances Social circumstances - Other, specify Social circumstances - Other, specifyPTCTCAE E13754 Social circumstances - Other, specify Soft tissue infection 10062255 NCIA disorder characterized by an infectious process involving soft tissues. Soft tissue infection NOSLLTMedDRA10049582 Soft tissue infectionLLTMedDRA10062255 Soft tissue infectionPTCTCAE C79745 E11579 Soft tissue infection Soft tissue necrosis lower limb 10065777 NCIA disorder characterized by a necrotic process occurring in the soft tissues of the lower extremity. Abdominal soft tissue necrosisLLTMedDRA10065775 Head soft tissue necrosisLLTMedDRA10065779 Neck soft tissue necrosisLLTMedDRA10065781 Pelvic soft tissue necrosisLLTMedDRA10065793 Soft tissue necrosis lower limbLLTMedDRA10065777 Soft tissue necrosis lower limbPTCTCAE Soft tissue necrosis upper limbLLTMedDRA10065778 Soft tissue necrosisLLTMedDRA10065769 C78620 E12525 Soft tissue necrosis lower limb Soft tissue necrosis upper limb 10065778 NCIA disorder characterized by a necrotic process occurring in the soft tissues of the upper extremity. Abdominal soft tissue necrosisLLTMedDRA10065775 Head soft tissue necrosisLLTMedDRA10065779 Neck soft tissue necrosisLLTMedDRA10065781 Pelvic soft tissue necrosisLLTMedDRA10065793 Soft tissue necrosis lower limbLLTMedDRA10065777 Soft tissue necrosis upper limbLLTMedDRA10065778 Soft tissue necrosis upper limbPTCTCAE Soft tissue necrosisLLTMedDRA10065769 C78621 E12530 Soft tissue necrosis upper limb Somnolence 10041349 NCIA disorder characterized by characterized by excessive sleepiness and drowsiness. Daytime sleepinessLLTMedDRA10011865 DrowsinessLLTMedDRA10013649 Drowsy on awakeningLLTMedDRA10013651 Excessive daytime sleepinessLLTMedDRA10015595 Feeling of residual sleepinessLLTMedDRA10016353 Groggy on awakeningLLTMedDRA10018732 GroggyLLTMedDRA10018730 Hard to awakenLLTMedDRA10019158 Less alert on arisingLLTMedDRA10024253 SleepinessLLTMedDRA10041014 SleepyLLTMedDRA10041018 SomnolenceLLTMedDRA10041349 SomnolencePTCTCAE C26754 E12814 Somnolence Sore throat 10041367 NCIA disorder characterized by of marked discomfort in the throat Chronic sore throatLLTMedDRA10066666 Laryngeal painLLTMedDRA10023848 Larynx burning pain ofLLTMedDRA10023899 Larynx painLLTMedDRA10023922 Oropharyngeal painLLTMedDRA10068319 Pain pharynxLLTMedDRA10033481 Pain throatLLTMedDRA10033494 Pharyngolaryngeal painLLTMedDRA10034844 Sore throat NOSLLTMedDRA10041368 Sore throatLLTMedDRA10041367 Sore throatPTCTCAE Throat painLLTMedDRA10043523 Throat soreLLTMedDRA10043524 C50747 E13575 Sore throat Spasticity 10041416 NCIA disorder characterized by increased involuntary muscle tone that affects the regions interfering with voluntary movement. It results in gait, movement, and speech disturbances. Arm spasticityLLTMedDRA10048970 Cortical thumbingLLTMedDRA10068713 Finger spasticityLLTMedDRA10016688 Leg scissoringLLTMedDRA10068714 Leg spasticityLLTMedDRA10024132 Muscle spasticity aggravatedLLTMedDRA10028336 Muscle spasticityLLTMedDRA10028335 Spasticity muscleLLTMedDRA10041418 SpasticityLLTMedDRA10041416 SpasticityPTCTCAE C79750 E12820 Spasticity Spermatic cord anastomotic leak 10065897 NCIA finding of leakage due to breakdown of a spermatic cord anastomosis (surgical connection of two separate anatomic structures). Fallopian tube anastomotic leakLLTMedDRA10065788 Reproductive tract anastomotic leakLLTMedDRA10065833 Spermatic cord anastomotic leakLLTMedDRA10065897 Spermatic cord anastomotic leakPTCTCAE Uterine anastomotic leakLLTMedDRA10065886 Vaginal anastomotic leakLLTMedDRA10065887 Vas deferens anastomotic leakLLTMedDRA10065888 C78622 E11948 Spermatic cord anastomotic leak Spermatic cord hemorrhage 10065762 NCIA disorder characterized by bleeding from the spermatic cord. Spermatic cord haemorrhageLLTMedDRA10065742 Spermatic cord hemorrhageLLTMedDRA10065762 Spermatic cord hemorrhagePTCTCAE Vas deferens haemorrhageLLTMedDRA10065750 Vas deferens hemorrhageLLTMedDRA10065896 C78623 E13205 Spermatic cord hemorrhage Spermatic cord obstruction 10065805 NCIA disorder characterized by blockage of the normal flow of the contents of the spermatic cord. Spermatic cord obstructionLLTMedDRA10065805 Spermatic cord obstructionPTCTCAE Vas deferens obstructionLLTMedDRA10065819 C78624 E13211 Spermatic cord obstruction Spinal fracture 10041569 NCIA finding of traumatic injury to the spine in which the continuity of a vertebral bone is broken. Spinal fracturePTCTCAE C80516 E11954 Spinal fracture Spleen disorder 10041633 NCIA disorder of the spleen. Disease of spleen, unspecifiedLLTMedDRA10013111 Disorder spleenLLTMedDRA10013271 Spleen disorder NOSLLTMedDRA10041634 Spleen disorderLLTMedDRA10041633 Spleen disorderPTCTCAE Spleen nodulesLLTMedDRA10059074 C35823 E10056 Spleen disorder Splenic infection 10062112 NCIA disorder characterized by an infectious process involving the spleen. Splenic infection NOSLLTMedDRA10051724 Splenic infectionLLTMedDRA10062112 Splenic infectionPTCTCAE C78627 E11584 Splenic infection Stenosis of gastrointestinal stoma 10065898 NCIA finding of narrowing of the gastrointestinal stoma (surgically created opening on the surface of the body). Colostomy malfunctionLLTMedDRA10010047 Colostomy prolapseLLTMedDRA10058044 Continent ileostomy complicationLLTMedDRA10058932 Gastrointestinal stoma complicationLLTMedDRA10065718 Gastrointestinal stoma necrosisLLTMedDRA10065712 Ileostomy malfunctionLLTMedDRA10021324 Ileostomy overactiveLLTMedDRA10021326 Ileostomy underactiveLLTMedDRA10059093 Intestinal stoma complicationLLTMedDRA10059060 Intestinal stoma leakLLTMedDRA10059095 Intestinal stoma obstructionLLTMedDRA10059094 Jejunostomy malfunctionLLTMedDRA10052091 Obstructed colostomyLLTMedDRA10059092 Obstructed ileostomyLLTMedDRA10059091 Other complication of colostomy or enterostomyLLTMedDRA10031765 Overactive ileostomyLLTMedDRA10033290 Prolapse of intestinal stomaLLTMedDRA10065745 Stenosis of gastrointestinal stomaLLTMedDRA10065898 Stenosis of gastrointestinal stomaPTCTCAE Stomal nipple complicationLLTMedDRA10058933 Unspecified complication of colostomy and enterostomyLLTMedDRA10045671 C78628 E11960 Stenosis of gastrointestinal stoma Stevens-Johnson syndrome 10042033 NCIA disorder characterized by less than 10% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes. Bullous erythema multiformeLLTMedDRA10006561 Erythema multiforme majorLLTMedDRA10015220 Erythema multiforme severeLLTMedDRA10015222 Stevens Johnson reactionLLTMedDRA10042029 Stevens Johnson syndromeLLTMedDRA10042030 Stevens Johnson type reactionLLTMedDRA10042031 Stevens-Johnson syndromeLLTMedDRA10042033 Stevens-Johnson syndromePTCTCAE Syndrome Stevens-JohnsonLLTMedDRA10042849 Toxic epitheliolysisLLTMedDRA10058452 Toxic respiratory epitheliolysisLLTMedDRA10058445 C79484 E13736 Stevens-Johnson syndrome Stoma site infection 10064505 NCIA disorder characterized by an infectious process involving a stoma (surgically created opening on the surface of the body). Infection (chronic) of amputation stumpLLTMedDRA10021790 Infection of amputation stumpLLTMedDRA10066432 Post procedural site wound infectionLLTMedDRA10056641 Postoperative wound infectionLLTMedDRA10036410 Stoma site infectionLLTMedDRA10064505 Stoma site infectionPTCTCAE Surgical wound infectionLLTMedDRA10053562 Suture line infectionLLTMedDRA10059055 C78629 E11588 Stoma site infection Stomach pain 10042112 NCIA disorder characterized by a sensation of marked discomfort in the stomach. Abdominal pain peptic ulcer typeLLTMedDRA10000086 Abdominal pain upperLLTMedDRA10000087 Ache stomachLLTMedDRA10000429 Acute gastric painLLTMedDRA10066612 Chronic epigastric painLLTMedDRA10066562 EpigastralgiaLLTMedDRA10048944 Epigastric acheLLTMedDRA10015014 Epigastric pain not food-relatedLLTMedDRA10015028 Epigastric painLLTMedDRA10015026 GastralgiaLLTMedDRA10064906 Gastric painLLTMedDRA10017814 Gastric spasmLLTMedDRA10064215 Hypochondrial painLLTMedDRA10020964 Hypochondrium pain leftLLTMedDRA10050044 Hypochondrium pain rightLLTMedDRA10020966 Left upper quadrant painLLTMedDRA10059592 Pain epigastricLLTMedDRA10033394 Pain gastricLLTMedDRA10033402 Pain hungerLLTMedDRA10033407 Pain right upper quadrantLLTMedDRA10033489 Pain stomachLLTMedDRA10033492 Pancreatic painLLTMedDRA10059606 Pressure sensation of right hypochondriumLLTMedDRA10036650 RUQ painLLTMedDRA10039338 Right upper quadrant painLLTMedDRA10039162 Splenic flexure syndromeLLTMedDRA10052502 Stomach acheLLTMedDRA10042076 Stomach crampsLLTMedDRA10049901 Stomach dull pain ofLLTMedDRA10042102 Stomach painLLTMedDRA10042112 Stomach painPTCTCAE StomachacheLLTMedDRA10042126 Ulcer type painLLTMedDRA10045343 Upper abdominal painLLTMedDRA10046272 C78630 E11044 Stomach pain Stomal ulcer 10042127 NCIA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the jejunal mucosal surface close to the anastomosis site following a gastroenterostomy procedure. Acute gastrojejunal ulcer without mention of haemorrhage or perforationLLTMedDRA10000783 Acute gastrojejunal ulcer without mention of hemorrhage or perforationLLTMedDRA10000784 Anastomotic ulcerLLTMedDRA10002243 Chronic gastrojejunal ulcer without mention of haemorrhage or perforationLLTMedDRA10008884 Chronic gastrojejunal ulcer without mention of hemorrhage or perforationLLTMedDRA10008885 Gastro-jejunal ulcerLLTMedDRA10017881 Gastrojejunal ulcerLLTMedDRA10018035 Stomal ulcerLLTMedDRA10042127 Stomal ulcerPTCTCAE Ulcer gastrojejunalLLTMedDRA10045307 C79766 E11965 Stomal ulcer Stridor 10042241 NCIA disorder characterized by a high pitched breathing sound due to laryngeal or upper airway obstruction. Stridor inspiratoryLLTMedDRA10042242 StridorLLTMedDRA10042241 StridorPTCTCAE C78632 E13579 Stridor Stroke 10042244 NCIA disorder characterized by a sudden loss of sensory function due to an intracranial vascular event. Accident cerebrovascularLLTMedDRA10000374 Apoplectic fitLLTMedDRA10058010 ApoplexyLLTMedDRA10003004 CVALLTMedDRA10011693 Cerebrovascular accident NOSLLTMedDRA10008191 Cerebrovascular accidentLLTMedDRA10008190 Late effects of cerebral strokeLLTMedDRA10049599 Middle cerebral artery strokeLLTMedDRA10027580 StrokeLLTMedDRA10042244 StrokePTCTCAE Worsening of strokeLLTMedDRA10049196 C3390 E12826 Stroke Sudden death NOS 10042435 NCIAn unexpected cessation of life that cannot be attributed to a CTCAE term associated with Grade 5. Sudden death NOSPTCTCAE C50911 E11171 Sudden death NOS Suicidal ideation 10042458 NCIA disorder characterized by thoughts of taking one's own life. Suicidal ideationPTCTCAE C80102 E12964 Suicidal ideation Suicide attempt 10042464 NCIA disorder characterized by self-inflicted harm in an attempt to end one's own life. Attempted suicideLLTMedDRA10003728 Suicide attempt other than overdoseLLTMedDRA10042465 Suicide attemptLLTMedDRA10042464 Suicide attemptPTCTCAE Unsuccessful suicideLLTMedDRA10046262 C80111 E12969 Suicide attempt Superficial soft tissue fibrosis 10065798 NCIA disorder characterized by fibrotic degeneration of the superficial soft tissues. Fibrosis deep connective tissueLLTMedDRA10065799 Soft tissue disorder NOSLLTMedDRA10041289 Soft tissue disorderLLTMedDRA10061366 Superficial soft tissue fibrosisLLTMedDRA10065798 Superficial soft tissue fibrosisPTCTCAE C78633 E12535 Superficial soft tissue fibrosis Superficial thrombophlebitis 10042554 NCIA disorder characterized by a blood clot and inflammation involving a superficial vein of the extremities. Superficial phlebothrombosisLLTMedDRA10042545 Superficial thrombophlebitis in pregnancy and the puerperiumLLTMedDRA10042556 Superficial thrombophlebitis of legLLTMedDRA10042557 Superficial thrombophlebitis, antepartumLLTMedDRA10042560 Superficial thrombophlebitisLLTMedDRA10042554 Superficial thrombophlebitisPTCTCAE Superficial thrombosis of veinsLLTMedDRA10042562 Superficial venous thrombosis of armLLTMedDRA10042563 Superficial venous thrombosis of legLLTMedDRA10042564 Thrombophlebitis arm superficialLLTMedDRA10043573 Thrombophlebitis leg superficialLLTMedDRA10043579 Thrombophlebitis multiple superficialLLTMedDRA10043585 Thrombophlebitis superficialLLTMedDRA10043595 Thrombosis of leg superficial venousLLTMedDRA10043631 Thrombosis venous superficialLLTMedDRA10043643 Venous thrombosis superficial (limbs)LLTMedDRA10047256 Venous thrombosis superficial limbLLTMedDRA10047257 C78634 E13817 Superficial thrombophlebitis Superior vena cava syndrome NCIA disorder characterized by obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache. Superior vena cava syndromePTCTCAE C3396 E13819 Superior vena cava syndrome Supraventricular tachycardia 10042604 NCIA disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates above the ventricles. AV nodal reentrant tachycardiaLLTMedDRA10003857 AV nodal tachycardiaLLTMedDRA10003858 AV reentrant tachycardiaLLTMedDRA10003859 Acute supraventricular tachycardiaLLTMedDRA10066662 Atrioventricular nodal reentrant tachycardiaLLTMedDRA10003682 Bouveret-Hoffmann syndromeLLTMedDRA10067520 Paroxysmal supraventricular tachycardiaLLTMedDRA10034044 Paroxysmal tachycardia (supraventricular)LLTMedDRA10034046 SVTLLTMedDRA10042644 Supraventricular tachycardiaLLTMedDRA10042604 Supraventricular tachycardiaPTCTCAE Tachycardia supraventricularLLTMedDRA10043084 Wide complex supraventricular tachycardiaLLTMedDRA10057507 C35061 E10218 Supraventricular tachycardia Surgical and medical procedures 10042613 Surgical and medical proceduresPTCTCAE E13852 Surgical and medical procedures Surgical and medical procedures - Other, specify Surgical and medical procedures - Other, specifyPTCTCAE E13760 Surgical and medical procedures - Other, specify Syncope 10042772 NCIA disorder characterized by spontaneous loss of consciousness caused by insufficient blood supply to the brain. Cardiac syncopeLLTMedDRA10064922 FaintLLTMedDRA10016167 FaintingLLTMedDRA10016169 Neurally mediated syncopeLLTMedDRA10067550 Neurocardiogenic syncopeLLTMedDRA10067813 Orthostatic collapseLLTMedDRA10048916 Syncopal attackLLTMedDRA10042771 Syncope aggravatedLLTMedDRA10048352 Syncope convulsiveLLTMedDRA10062496 Syncope exertionalLLTMedDRA10042774 Syncope hypotensiveLLTMedDRA10060743 Syncope micturitionLLTMedDRA10051888 Syncope posturalLLTMedDRA10042775 Syncope vasovagalLLTMedDRA10042777 SyncopeLLTMedDRA10042772 SyncopePTCTCAE Tussive syncopeLLTMedDRA10064035 C35053 E12832 Syncope Telangiectasia 10043189 NCIA disorder characterized by local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes. Multiple telangiectasesLLTMedDRA10028253 TelangiectasiaLLTMedDRA10043189 TelangiectasiaPTCTCAE Telangiectasis facialLLTMedDRA10043194 TelangiectasisLLTMedDRA10043193 C28194 E13740 Telangiectasia Testicular disorder 10043306 NCIA disorder characterized by involvement of the testis. Disorder testicleLLTMedDRA10013273 Dysfunction testicularLLTMedDRA10013906 Testicular disorder NOSLLTMedDRA10043307 Testicular disorderLLTMedDRA10043306 Testicular disorderPTCTCAE Testicular dysfunctionLLTMedDRA10043308 Testicular indurationLLTMedDRA10068041 Testis disorderLLTMedDRA10043361 Unspecified testicular dysfunctionLLTMedDRA10046180 C26890 E13215 Testicular disorder Testicular hemorrhage 10055347 NCIA disorder characterized by bleeding from the testis. Testicular haemorrhageLLTMedDRA10051877 Testicular hemorrhageLLTMedDRA10055347 Testicular hemorrhagePTCTCAE C78635 E13221 Testicular hemorrhage Testicular pain 10043345 NCIA disorder characterized by a sensation of marked discomfort in the testis. Ache in testisLLTMedDRA10000427 Pain in testisLLTMedDRA10033449 Testicular painLLTMedDRA10043345 Testicular painPTCTCAE C78636 E13227 Testicular pain Thromboembolic event 10043565 NCIA disorder characterized by occlusion of a vessel by a thrombus that has migrated from a distal site via the blood stream. Arterial embolism NOSLLTMedDRA10003160 Circulating thrombusLLTMedDRA10068903 Embolism NOSLLTMedDRA10014499 Embolism arterialLLTMedDRA10014513 EmbolismLLTMedDRA10061169 EmbolusLLTMedDRA10014525 Thromboembolic eventLLTMedDRA10043565 Thromboembolic eventPTCTCAE Thromboembolism NOSLLTMedDRA10043567 ThromboembolismLLTMedDRA10043566 C28195 E13825 Thromboembolic event Thrombotic thrombocytopenic purpura 10043648 NCIA disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition. Purpura thrombopaenic thromboticLLTMedDRA10037562 Purpura thrombopenic thromboticLLTMedDRA10037563 Thrombocytopenic purpura, thromboticLLTMedDRA10043562 Thrombotic thrombocytopenic purpuraLLTMedDRA10043648 Thrombotic thrombocytopenic purpuraPTCTCAE C78797 E10061 Thrombotic thrombocytopenic purpura Tinnitus 10043882 NCIA disorder characterized by noise in the ears, such as ringing, buzzing, roaring or clicking. Aggravated ringing in earsLLTMedDRA10001483 Ear buzzingLLTMedDRA10013996 Ear cracklingLLTMedDRA10014001 Ear hissingLLTMedDRA10014010 Ear noisesLLTMedDRA10014018 Ear ringingLLTMedDRA10014023 Ear roaringLLTMedDRA10014024 Noises in headLLTMedDRA10029501 Objective tinnitusLLTMedDRA10029886 Pulsatile tinnitusLLTMedDRA10064630 Ringing in earsLLTMedDRA10039183 Subjective tinnitusLLTMedDRA10042398 Tinnitus aggravatedLLTMedDRA10043883 Tinnitus, unspecifiedLLTMedDRA10043884 TinnitusLLTMedDRA10043882 TinnitusPTCTCAE Worsening of tinnitusLLTMedDRA10048029 C50772 E10287 Tinnitus Tooth development disorder 10044030 NCIA disorder characterized by a pathological process of the teeth occurring during tooth development. Eruption of natal teethLLTMedDRA10064165 Natal teethLLTMedDRA10064164 Tooth development disorderLLTMedDRA10044030 Tooth development disorderPTCTCAE Unspecified disorder of tooth development and eruptionLLTMedDRA10045833 C35596 E11048 Tooth development disorder Tooth discoloration 10044031 NCIA disorder characterized by a change in tooth hue or tint. Discoloration toothLLTMedDRA10013079 Discolouration toothLLTMedDRA10056125 Enamel mottlingLLTMedDRA10014578 Fluorescence toothLLTMedDRA10016815 Mottled teethLLTMedDRA10028011 Mottling enamelLLTMedDRA10028012 Post eruptive color changes of teethLLTMedDRA10057233 Post eruptive colour changes of teethLLTMedDRA10057232 Stain toothLLTMedDRA10041906 Teeth mottledLLTMedDRA10043177 Teeth mottlingLLTMedDRA10043178 Teeth stainedLLTMedDRA10043179 Teeth stainingLLTMedDRA10043180 Teeth yellowLLTMedDRA10043181 Tooth colored yellowLLTMedDRA10055541 Tooth coloured yellowLLTMedDRA10044024 Tooth discolorationLLTMedDRA10044031 Tooth discolorationPTCTCAE Tooth discolourationLLTMedDRA10044032 C80112 E11052 Tooth discoloration Tooth infection 10048762 NCIA disorder characterized by an infectious process involving a tooth. Tooth infectionLLTMedDRA10048762 Tooth infectionPTCTCAE C78639 E11594 Tooth infection Toothache 10044055 NCIA disorder characterized by a sensation of marked discomfort in the tooth. OdontalgiaLLTMedDRA10030090 Tooth acheLLTMedDRA10044017 Tooth painLLTMedDRA10059723 ToothacheLLTMedDRA10044055 ToothachePTCTCAE C78640 E11054 Toothache Toxic epidermal necrolysis 10044223 NCIA disorder characterized by greater than 30% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes. Drug eruption Lyell syndrome typeLLTMedDRA10013691 Epidermal necrolysisLLTMedDRA10014986 Lyell syndromeLLTMedDRA10025166 Lyell's diseaseLLTMedDRA10025167 Lyell's syndromeLLTMedDRA10025168 Necrolysis epidermal toxic (Lyell type)LLTMedDRA10028849 Necrolysis epidermalLLTMedDRA10028848 TENLLTMedDRA10043221 Toxic epidermal necrolysisLLTMedDRA10044223 Toxic epidermal necrolysisPTCTCAE C79777 E13743 Toxic epidermal necrolysis Tracheal fistula 10065787 NCIA disorder characterized by an abnormal communication between the trachea and another organ or anatomic site. Tracheal fistulaLLTMedDRA10065787 Tracheal fistulaPTCTCAE Tracheobronchial fistulaLLTMedDRA10067430 C78641 E13583 Tracheal fistula Tracheal hemorrhage 10062548 NCIA finding of bleeding from the trachea. Tracheal haemorrhageLLTMedDRA10062543 Tracheal hemorrhageLLTMedDRA10062548 Tracheal hemorrhagePTCTCAE C78642 E11969 Tracheal hemorrhage Tracheal mucositis 10065900 NCIA disorder characterized by an inflammation involving the mucous membrane of the trachea. Tracheal inflammationLLTMedDRA10065899 Tracheal mucositisLLTMedDRA10065900 Tracheal mucositisPTCTCAE C78644 E13589 Tracheal mucositis Tracheal obstruction 10044291 NCIA finding of blockage of the lumen of the trachea. Tracheal obstruction NOSLLTMedDRA10044295 Tracheal obstruction by foreign bodyLLTMedDRA10044292 Tracheal obstruction intraluminalLLTMedDRA10044294 Tracheal obstructionLLTMedDRA10044291 Tracheal obstructionPTCTCAE C78645 E11975 Tracheal obstruction Tracheal stenosis 10050816 NCIA disorder characterized by a narrowing of the trachea. Tracheal stenosisLLTMedDRA10050816 Tracheal stenosisPTCTCAE C78646 E13595 Tracheal stenosis Tracheitis 10044302 NCIA disorder characterized by an infectious process involving the trachea. Acute laryngotracheitisLLTMedDRA10000827 Acute tracheitisLLTMedDRA10001095 Chronic laryngotracheitisLLTMedDRA10008942 Laryngo-tracheitis acute NOSLLTMedDRA10023883 Laryngotracheitis NOSLLTMedDRA10023896 Laryngotracheitis acute NOSLLTMedDRA10023894 Laryngotracheitis chronic NOSLLTMedDRA10023895 LaryngotracheitisLLTMedDRA10023882 Tracheitis NOSLLTMedDRA10044303 TracheitisLLTMedDRA10044302 TracheitisPTCTCAE C78647 E11599 Tracheitis Tracheostomy site bleeding 10065749 NCIA finding of blood leakage from the tracheostomy site. Bleeding after stem cell transplantationLLTMedDRA10056503 Bleeding of suture siteLLTMedDRA10005125 Bleeding postoperativeLLTMedDRA10005127 Intestinal stoma site bleedingLLTMedDRA10049468 Post biopsy bleedingLLTMedDRA10054113 Post procedural bleedingLLTMedDRA10051014 Post procedural haemorrhageLLTMedDRA10051077 Post procedural hemorrhageLLTMedDRA10055320 Postoperative bleedingLLTMedDRA10036277 Postoperative haemorrhageLLTMedDRA10054709 Postoperative hemorrhageLLTMedDRA10055322 Stoma site bleedingLLTMedDRA10059020 Tracheostomy site bleedingLLTMedDRA10065749 Tracheostomy site bleedingPTCTCAE Urostomy site bleedingLLTMedDRA10065748 C78648 E11981 Tracheostomy site bleeding Transient ischemic attacks 10044391 NCIA disorder characterized by a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit. Intermittent cerebral claudicationLLTMedDRA10022561 MinistrokeLLTMedDRA10063751 Recurrent TIALLTMedDRA10068312 TIALLTMedDRA10043821 Transient cerebral ischaemiaLLTMedDRA10044374 Transient cerebral ischemiaLLTMedDRA10044375 Transient ischaemic attackLLTMedDRA10044390 Transient ischemic attacksLLTMedDRA10044391 Transient ischemic attacksPTCTCAE Unspecified transient cerebral ischaemiaLLTMedDRA10055755 Unspecified transient cerebral ischemiaLLTMedDRA10046183 C50781 E12834 Transient ischemic attacks Treatment related secondary malignancy 10049737 NCIA disorder characterized by development of a malignancy most probably as a result of treatment for a previously existing malignancy. Treatment related secondary malignancyLLTMedDRA10049737 Treatment related secondary malignancyPTCTCAE C4969 E12561 Treatment related secondary malignancy Tremor 10044565 NCIA disorder characterized by the uncontrolled shaking movement of the whole body or individual parts. Parkinsonian-like tremorLLTMedDRA10034009 ShakinessLLTMedDRA10040527 Shaking of handsLLTMedDRA10040530 ShakingLLTMedDRA10040528 Tongue tremorLLTMedDRA10043990 TrembleLLTMedDRA10044562 TremblingLLTMedDRA10044563 Tremor aggravatedLLTMedDRA10048329 Tremor coarseLLTMedDRA10044567 Tremor fineLLTMedDRA10044569 Tremor fingerLLTMedDRA10044570 Tremor limbLLTMedDRA10044572 Tremor muscleLLTMedDRA10044573 Tremor nerveLLTMedDRA10044576 Tremor of handsLLTMedDRA10044577 Tremor perioralLLTMedDRA10044578 Tremor semirrhythmicLLTMedDRA10044579 TremorLLTMedDRA10044565 TremorPTCTCAE TremulousnessLLTMedDRA10044580 C38038 E12837 Tremor Tricuspid valve disease 10061389 NCIA disorder characterized by a defect in tricuspid valve function or structure. Diseases of tricuspid valveLLTMedDRA10013138 Tricuspid dysfunctionLLTMedDRA10044633 Tricuspid valve disease NOSLLTMedDRA10044638 Tricuspid valve diseaseLLTMedDRA10061389 Tricuspid valve diseasePTCTCAE Tricuspid valve disorders, specified as non-rheumaticLLTMedDRA10057746 C78649 E10224 Tricuspid valve disease Trigeminal nerve disorder 10060890 NCIA disorder characterized by involvement of the trigeminal nerve (fifth cranial nerve). Trigeminal nerve disorder NOSLLTMedDRA10044647 Trigeminal nerve disorder, unspecifiedLLTMedDRA10044648 Trigeminal nerve disorderLLTMedDRA10060890 Trigeminal nerve disorderPTCTCAE C26952 E12841 Trigeminal nerve disorder Trismus 10044684 NCIA disorder characterized by lack of ability to open the mouth fully due to a decrease in the range of motion of the muscles of mastication. Jaw crampLLTMedDRA10023145 Jaw movements disturbanceLLTMedDRA10023155 Jaw spasmLLTMedDRA10023158 LockjawLLTMedDRA10024793 Rigidity masticatoryLLTMedDRA10039171 Spasm temporomandibularLLTMedDRA10041402 TrismusLLTMedDRA10044684 TrismusPTCTCAE C78651 E12541 Trismus Tumor lysis syndrome 10045152 NCIA disorder characterized by metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells. Tumor lysis syndromeLLTMedDRA10045152 Tumor lysis syndromePTCTCAE Tumour lysis syndromeLLTMedDRA10045170 C3425 E12365 Tumor lysis syndrome Tumor pain 10045158 NCIA disorder characterized by marked discomfort from a neoplasm that may be pressing on a nerve, blocking blood vessels, inflamed or fractured from metastasis. Tumor painLLTMedDRA10045158 Tumor painPTCTCAE Tumour painLLTMedDRA10045171 C78656 E12565 Tumor pain Typhlitis 10045271 NCIA disorder characterized by inflammation of the cecum. Caecal inflammationLLTMedDRA10006917 CaecitisLLTMedDRA10006919 Cecal inflammationLLTMedDRA10055442 CecitisLLTMedDRA10007859 TyphlitisLLTMedDRA10045271 TyphlitisPTCTCAE C38043 E11058 Typhlitis Unequal limb length 10065738 NCIA disorder characterized by of a discrepancy between the lengths of the lower or upper extremities. Unequal arm lengthLLTMedDRA10052345 Unequal leg length (acquired)LLTMedDRA10045521 Unequal leg length acquiredLLTMedDRA10053207 Unequal leg lengthLLTMedDRA10052432 Unequal limb lengthLLTMedDRA10065738 Unequal limb lengthPTCTCAE C78657 E12545 Unequal limb length Unintended pregnancy 10045542 NCIA disorder characterized by an unexpected pregnancy at the time of conception. Pregnancy unexpectedLLTMedDRA10036579 Pregnancy unintendedLLTMedDRA10036580 Unexpected pregnancyLLTMedDRA10045526 Unintended pregnancyLLTMedDRA10045542 Unintended pregnancyPTCTCAE C79801 E12872 Unintended pregnancy Upper gastrointestinal hemorrhage 10055356 NCIA disorder characterized by bleeding from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach). UGI bleedLLTMedDRA10045284 Upper GI blood lossLLTMedDRA10046284 Upper gastrointestinal haemorrhageLLTMedDRA10046274 Upper gastrointestinal hemorrhageLLTMedDRA10055356 Upper gastrointestinal hemorrhagePTCTCAE C78660 E11062 Upper gastrointestinal hemorrhage Upper respiratory infection 10046300 NCIA disorder characterized by an infectious process involving the upper respiratory tract (nose, paranasal sinuses, pharynx, larynx, or trachea). Acute upper respiratory tract infectionLLTMedDRA10066679 Infection upper respiratoryLLTMedDRA10021871 URTI (upper respiratory tract infection)LLTMedDRA10046734 URTILLTMedDRA10046733 Upper respiratory infectionLLTMedDRA10046300 Upper respiratory infectionPTCTCAE Upper respiratory tract infection NOSLLTMedDRA10046307 Upper respiratory tract infectionLLTMedDRA10046306 C35650 E11604 Upper respiratory infection Ureteric anastomotic leak 10065814 NCIA finding of leakage due to breakdown of a ureteral anastomosis (surgical connection of two separate anatomic structures). Bladder anastomotic leakLLTMedDRA10065802 Kidney anastomotic leakLLTMedDRA10065803 Ureteric anastomotic leakLLTMedDRA10065814 Ureteric anastomotic leakPTCTCAE Urethral anastomotic leakLLTMedDRA10065815 Urinary anastomotic leakLLTMedDRA10060775 C78662 E11987 Ureteric anastomotic leak Urethral anastomotic leak 10065815 NCIA finding of leakage due to breakdown of a urethral anastomosis (surgical connection of two separate anatomic structures). Bladder anastomotic leakLLTMedDRA10065802 Kidney anastomotic leakLLTMedDRA10065803 Ureteric anastomotic leakLLTMedDRA10065814 Urethral anastomotic leakLLTMedDRA10065815 Urethral anastomotic leakPTCTCAE Urinary anastomotic leakLLTMedDRA10060775 C78667 E11993 Urethral anastomotic leak Urethral infection 10052298 NCIA disorder characterized by an infectious process involving the urethra. Non-gonococcal urethritis, otherLLTMedDRA10057715 Non-gonococcal urethritisLLTMedDRA10029545 Penile bulbitisLLTMedDRA10060739 Post gonococcal urethritisLLTMedDRA10036257 Unspecified non-gonococcal urethritis (NGU)LLTMedDRA10057747 Urethral bulbitisLLTMedDRA10059855 Urethral infectionLLTMedDRA10052298 Urethral infectionPTCTCAE Urethritis (non-venereal)LLTMedDRA10046481 Urethritis non-specificLLTMedDRA10046487 Urethritis nonspecificLLTMedDRA10046488 Urethritis, unspecifiedLLTMedDRA10046492 UrethritisLLTMedDRA10046480 C78671 E11609 Urethral infection Urinary fistula 10065368 NCIA disorder characterized by an abnormal communication between any part of the urinary system and another organ or anatomic site. Urinary fistulaPTCTCAE C79850 E13034 Urinary fistula Urinary frequency 10046539 NCIA disorder characterized by urination at short intervals. Urinary frequencyPTCTCAE C26906 E13039 Urinary frequency Urinary incontinence 10046543 NCIA disorder characterized by inability to control the flow of urine from the bladder. AconuresisLLTMedDRA10065361 Bladder incontinenceLLTMedDRA10005046 Continuous urinary leakageLLTMedDRA10062620 Dribbling of urineLLTMedDRA10013639 Incontinence of urineLLTMedDRA10021642 Incontinence urinaryLLTMedDRA10021643 Incontinent of urine (excl emotional)LLTMedDRA10021647 Micturition involuntaryLLTMedDRA10027563 Unspecified urinary incontinenceLLTMedDRA10046218 Urinary incontinence aggravatedLLTMedDRA10048335 Urinary incontinenceLLTMedDRA10046543 Urinary incontinencePTCTCAE Urination involuntaryLLTMedDRA10046602 Urine incontinenceLLTMedDRA10046645 C78497 E13042 Urinary incontinence Urinary retention 10046555 NCIA disorder characterized by accumulation of urine within the bladder because of the inability to urinate. Acute retention of urineLLTMedDRA10001055 Bladder inability to emptyLLTMedDRA10005045 Bladder retentionLLTMedDRA10005071 Chronic retention of urineLLTMedDRA10009127 Other specified retention of urineLLTMedDRA10032882 Retention of urineLLTMedDRA10038781 Retention urinaryLLTMedDRA10038783 Retention urineLLTMedDRA10038784 Retention with overflowLLTMedDRA10038786 Urinary retentionLLTMedDRA10046555 Urinary retentionPTCTCAE C50790 E13046 Urinary retention Urinary tract infection 10046571 NCIA disorder characterized by an infectious process involving the urinary tract, most commonly the bladder and the urethra. Chronic UTILLTMedDRA10009160 Infection urinary tractLLTMedDRA10021872 Lower urinary tract infectionLLTMedDRA10024981 Recurrent UTILLTMedDRA10038141 Recurrent urinary tract infectionLLTMedDRA10038140 UTILLTMedDRA10046848 Urinary infectionLLTMedDRA10046544 Urinary tract infection NOSLLTMedDRA10046574 Urinary tract infection, site not specifiedLLTMedDRA10046576 Urinary tract infectionLLTMedDRA10046571 Urinary tract infectionPTCTCAE C50791 E11614 Urinary tract infection Urinary tract obstruction 10061574 NCIA disorder characterized by blockage of the normal flow of contents of the urinary tract. Urinary obstruction unspecifiedLLTMedDRA10046548 Urinary tract obstruction NOSLLTMedDRA10046587 Urinary tract obstructionLLTMedDRA10061574 Urinary tract obstructionPTCTCAE C79805 E13052 Urinary tract obstruction Urinary tract pain 10062225 NCIA disorder characterized by a sensation of marked discomfort in the urinary tract. Urinary tract painPTCTCAE C83493 E13058 Urinary tract pain Urinary urgency 10046593 NCIA disorder characterized by a sudden compelling urge to urinate. Urinary urgencyPTCTCAE C50792 E13062 Urinary urgency Urine discoloration 10046628 NCIA disorder characterized by a change in the color of the urine. Brown urineLLTMedDRA10058129 ChromaturiaLLTMedDRA10008796 Discoloration urineLLTMedDRA10013080 Discolouration urineLLTMedDRA10056126 Red urineLLTMedDRA10038197 Urine coloring blackLLTMedDRA10055543 Urine coloring yellowLLTMedDRA10055544 Urine colouring blackLLTMedDRA10046618 Urine colouring yellowLLTMedDRA10046619 Urine discolorationLLTMedDRA10046628 Urine discolorationPTCTCAE Urine discolourationLLTMedDRA10046629 C78678 E13065 Urine discoloration Urine output decreased 10059895 NCIA finding based on test results that indicate urine production is less relative to previous output. Urine output decreasedPTCTCAE C80522 E12217 Urine output decreased Urostomy leak 10065882 NCIA finding of leakage of contents from a urostomy. Prolapse of urostomyLLTMedDRA10065822 Urostomy complicationLLTMedDRA10065816 Urostomy leakLLTMedDRA10065882 Urostomy leakPTCTCAE Urostomy obstructionLLTMedDRA10065883 Urostomy perforationLLTMedDRA10065884 Urostomy stenosisLLTMedDRA10065885 C78679 E11999 Urostomy leak Urostomy obstruction 10065883 NCIA finding of blockage of the urostomy. Prolapse of urostomyLLTMedDRA10065822 Urostomy complicationLLTMedDRA10065816 Urostomy leakLLTMedDRA10065882 Urostomy obstructionLLTMedDRA10065883 Urostomy obstructionPTCTCAE Urostomy perforationLLTMedDRA10065884 Urostomy stenosisLLTMedDRA10065885 C78680 E12005 Urostomy obstruction Urostomy site bleeding 10065748 NCIA finding of bleeding from the urostomy site. Bleeding after stem cell transplantationLLTMedDRA10056503 Bleeding of suture siteLLTMedDRA10005125 Bleeding postoperativeLLTMedDRA10005127 Intestinal stoma site bleedingLLTMedDRA10049468 Post biopsy bleedingLLTMedDRA10054113 Post procedural bleedingLLTMedDRA10051014 Post procedural haemorrhageLLTMedDRA10051077 Post procedural hemorrhageLLTMedDRA10055320 Postoperative bleedingLLTMedDRA10036277 Postoperative haemorrhageLLTMedDRA10054709 Postoperative hemorrhageLLTMedDRA10055322 Stoma site bleedingLLTMedDRA10059020 Tracheostomy site bleedingLLTMedDRA10065749 Urostomy site bleedingLLTMedDRA10065748 Urostomy site bleedingPTCTCAE C78682 E12011 Urostomy site bleeding Urostomy stenosis 10065885 NCIA finding of narrowing of the opening of a urostomy. Prolapse of urostomyLLTMedDRA10065822 Urostomy complicationLLTMedDRA10065816 Urostomy leakLLTMedDRA10065882 Urostomy obstructionLLTMedDRA10065883 Urostomy perforationLLTMedDRA10065884 Urostomy stenosisLLTMedDRA10065885 Urostomy stenosisPTCTCAE C78683 E12017 Urostomy stenosis Urticaria 10046735 NCIA disorder characterized by an itchy skin eruption characterized by wheals with pale interiors and well-defined red margins. Acute allergic urticariaLLTMedDRA10000659 Acute urticariaLLTMedDRA10001106 Allergic urticariaLLTMedDRA10001734 Erythema urticarialLLTMedDRA10015238 Generalised urticarial rashLLTMedDRA10018103 Generalised urticarialLLTMedDRA10018102 Generalized urticariaLLTMedDRA10049198 Generalized urticarial rashLLTMedDRA10062449 Histamine-like rashLLTMedDRA10020114 HivesLLTMedDRA10020197 Nettle rashLLTMedDRA10029220 Pharmacological urticariaLLTMedDRA10034806 Rash urticaria-likeLLTMedDRA10037895 Rash urticarialLLTMedDRA10037896 Subcutaneous urticariaLLTMedDRA10042357 Unspecified urticariaLLTMedDRA10046219 Urticaria NOSLLTMedDRA10046749 Urticaria acuteLLTMedDRA10046737 Urticaria aggravatedLLTMedDRA10046738 Urticaria drug-inducedLLTMedDRA10052570 Urticaria generalisedLLTMedDRA10052569 Urticaria localisedLLTMedDRA10060771 Urticaria localizedLLTMedDRA10060773 Urticaria recurrentLLTMedDRA10066680 Urticaria subcutaneousLLTMedDRA10046753 Urticaria, unspecifiedLLTMedDRA10046756 UrticariaLLTMedDRA10046735 UrticariaPTCTCAE Urticarial rashLLTMedDRA10046758 Urticarial symptomLLTMedDRA10046759 Urticated rashLLTMedDRA10046760 UrticationLLTMedDRA10046761 WeltsLLTMedDRA10047906 WhealsLLTMedDRA10047918 C3432 E13746 Urticaria Uterine anastomotic leak 10065886 NCIA finding of leakage due to breakdown of a uterine anastomosis (surgical connection of two separate anatomic structures). Fallopian tube anastomotic leakLLTMedDRA10065788 Reproductive tract anastomotic leakLLTMedDRA10065833 Spermatic cord anastomotic leakLLTMedDRA10065897 Uterine anastomotic leakLLTMedDRA10065886 Uterine anastomotic leakPTCTCAE Vaginal anastomotic leakLLTMedDRA10065887 Vas deferens anastomotic leakLLTMedDRA10065888 C78684 E12022 Uterine anastomotic leak Uterine fistula 10065811 NCIA disorder characterized by an abnormal communication between the uterus and another organ or anatomic site. Uterine fistulaLLTMedDRA10065811 Uterine fistulaPTCTCAE C78685 E13231 Uterine fistula Uterine hemorrhage 10046789 NCIA disorder characterized by bleeding from the uterus. Atonic haemorrhageLLTMedDRA10055762 Atonic hemorrhageLLTMedDRA10003627 Endometrial bleedingLLTMedDRA10014732 HaematometraLLTMedDRA10018859 Haemorrhage uterineLLTMedDRA10055848 HematometraLLTMedDRA10019443 Hemorrhage uterineLLTMedDRA10019592 Uterine bleedingLLTMedDRA10046765 Uterine haemorrhageLLTMedDRA10046788 Uterine hemorrhageLLTMedDRA10046789 Uterine hemorrhagePTCTCAE C78686 E13237 Uterine hemorrhage Uterine infection 10062233 NCIA disorder characterized by an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues. Uterine infection NOSLLTMedDRA10050447 Uterine infectionLLTMedDRA10062233 Uterine infectionPTCTCAE C26764 E11619 Uterine infection Uterine obstruction 10065928 NCIA disorder characterized by blockage of the uterine outlet. Uterine obstructionLLTMedDRA10065928 Uterine obstructionPTCTCAE C78693 E13243 Uterine obstruction Uterine pain 10046809 NCIA disorder characterized by a sensation of marked discomfort in the uterus. Uterine painLLTMedDRA10046809 Uterine painPTCTCAE C78694 E13247 Uterine pain Uterine perforation 10046810 NCIA disorder characterized by a rupture in the uterine wall. Perforation of uterusLLTMedDRA10034426 Perforation uterineLLTMedDRA10034431 Rupture of uterus before onset of laborLLTMedDRA10039314 Rupture of uterus before onset of labour, with deliveryLLTMedDRA10056168 Rupture of uterus before onset of labourLLTMedDRA10039318 Rupture of uterus during and after labourLLTMedDRA10039320 Rupture uterusLLTMedDRA10039327 Ruptured uterus (labor complication)LLTMedDRA10055571 Ruptured uterus (labour complication)LLTMedDRA10039336 Ruptured uterusLLTMedDRA10039335 Uterine perforation post proceduralLLTMedDRA10064537 Uterine perforationLLTMedDRA10046810 Uterine perforationPTCTCAE Uterine ruptureLLTMedDRA10046820 Uterus ruptureLLTMedDRA10046845 Uterus rupturedLLTMedDRA10046846 C50793 E12028 Uterine perforation Uveitis 10046851 NCIA disorder characterized by inflammation to the uvea of the eye. Acute uveitisLLTMedDRA10066681 Granulomatous uveitisLLTMedDRA10057919 PanuveitisLLTMedDRA10033687 Pars planitisLLTMedDRA10034052 Uveitis NOSLLTMedDRA10046855 UveitisLLTMedDRA10046851 UveitisPTCTCAE C26909 E10442 Uveitis Vaginal anastomotic leak 10065887 NCIA finding of leakage due to breakdown of a vaginal anastomosis (surgical connection of two separate anatomic structures). Fallopian tube anastomotic leakLLTMedDRA10065788 Reproductive tract anastomotic leakLLTMedDRA10065833 Spermatic cord anastomotic leakLLTMedDRA10065897 Uterine anastomotic leakLLTMedDRA10065886 Vaginal anastomotic leakLLTMedDRA10065887 Vaginal anastomotic leakPTCTCAE Vas deferens anastomotic leakLLTMedDRA10065888 C78698 E12034 Vaginal anastomotic leak Vaginal discharge 10046901 NCIA disorder characterized by vaginal secretions. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years. Discharge vaginalLLTMedDRA10013069 Fluor vaginalisLLTMedDRA10058695 Offensive vaginal dischargeLLTMedDRA10030260 Per vaginal dischargeLLTMedDRA10067034 Vaginal discharge abnormalityLLTMedDRA10057094 Vaginal dischargeLLTMedDRA10046901 Vaginal dischargePTCTCAE C50795 E13251 Vaginal discharge Vaginal dryness 10046904 NCIA disorder characterized by an uncomfortable feeling of itching and burning in the vagina. Dryness vaginalLLTMedDRA10013796 Vaginal drynessLLTMedDRA10046904 Vaginal drynessPTCTCAE Vulvovaginal drynessLLTMedDRA10047791 C78699 E13254 Vaginal dryness Vaginal fistula 10065813 NCIA disorder characterized by an abnormal communication between the vagina and another organ or anatomic site. Vaginal fistulaLLTMedDRA10065813 Vaginal fistulaPTCTCAE C79847 E13258 Vaginal fistula Vaginal hemorrhage 10046912 NCIA disorder characterized by bleeding from the vagina. Bleeding vaginalLLTMedDRA10005143 Bloody vaginal dischargeLLTMedDRA10049851 Haemorrhage from vaginaLLTMedDRA10018977 Haemorrhage vaginalLLTMedDRA10055849 Hemorrhage from vaginaLLTMedDRA10055265 Hemorrhage vaginalLLTMedDRA10019593 Per vaginal bleedingLLTMedDRA10034372 Spotting vaginalLLTMedDRA10048821 Vaginal bleedingLLTMedDRA10046883 Vaginal ecchymosisLLTMedDRA10063807 Vaginal haemorrhageLLTMedDRA10046910 Vaginal hemorrhageLLTMedDRA10046912 Vaginal hemorrhagePTCTCAE Vaginal petechiaeLLTMedDRA10063813 C26945 E13264 Vaginal hemorrhage Vaginal infection 10046914 NCIA disorder characterized by an infectious process involving the vagina. Acute vaginitisLLTMedDRA10001107 ColpitisLLTMedDRA10063128 Infantile vaginitisLLTMedDRA10049616 Non-specific vaginitisLLTMedDRA10029562 Vaginal infection NOSLLTMedDRA10046915 Vaginal infectionLLTMedDRA10046914 Vaginal infectionPTCTCAE VaginitisLLTMedDRA10046950 C26911 E11624 Vaginal infection Vaginal inflammation 10046916 NCIA disorder characterized by inflammation involving the vagina. Symptoms may include redness, edema, marked discomfort and an increase in vaginal discharge. Vaginal inflammationLLTMedDRA10046916 Vaginal inflammationPTCTCAE Vaginal mucositisLLTMedDRA10064282 C26911 E13270 Vaginal inflammation Vaginal obstruction 10065817 NCIA disorder characterized by blockage of vaginal canal. Vaginal obstructionLLTMedDRA10065817 Vaginal obstructionPTCTCAE C78700 E13276 Vaginal obstruction Vaginal pain 10046937 NCIA disorder characterized by a sensation of marked discomfort in the vagina. Vaginal painLLTMedDRA10046937 Vaginal painPTCTCAE VulvodyniaLLTMedDRA10047781 Vulvovaginal painLLTMedDRA10069055 C78701 E13280 Vaginal pain Vaginal perforation 10065818 NCIA disorder characterized by a rupture in the vaginal wall. Vaginal perforationLLTMedDRA10065818 Vaginal perforationPTCTCAE C78702 E13284 Vaginal perforation Vaginal stricture 10053496 NCIA disorder characterized by a narrowing of the vaginal canal. Vaginal strictureLLTMedDRA10053496 Vaginal stricturePTCTCAE C36064 E13290 Vaginal stricture Vaginismus 10046947 NCIA disorder characterized by involuntary spasms of the pelvic floor muscles, resulting in pathologic tightness of the vaginal wall during penetration such as during sexual intercourse. ColpospasmLLTMedDRA10054111 Psychogenic vaginismusLLTMedDRA10037204 Vaginal spasmLLTMedDRA10054110 Vaginismus (excl psychogenic)LLTMedDRA10046948 Vaginismus psychogenicLLTMedDRA10046949 VaginismusLLTMedDRA10046947 VaginismusPTCTCAE C78703 E13295 Vaginismus Vagus nerve disorder 10061403 NCIA disorder characterized by involvement of the vagus nerve (tenth cranial nerve). Vagus nerve disorder NOSLLTMedDRA10046966 Vagus nerve disorderLLTMedDRA10061403 Vagus nerve disorderPTCTCAE C27591 E12845 Vagus nerve disorder Vas deferens anastomotic leak 10065888 NCIA finding of leakage due to breakdown of a vas deferens anastomosis (surgical connection of two separate anatomic structures). Fallopian tube anastomotic leakLLTMedDRA10065788 Reproductive tract anastomotic leakLLTMedDRA10065833 Spermatic cord anastomotic leakLLTMedDRA10065897 Uterine anastomotic leakLLTMedDRA10065886 Vaginal anastomotic leakLLTMedDRA10065887 Vas deferens anastomotic leakLLTMedDRA10065888 Vas deferens anastomotic leakPTCTCAE C78704 E12040 Vas deferens anastomotic leak Vascular access complication 10062169 NCIA finding of a previously undocumented problem related to the vascular access site. Vascular access NOS complicationLLTMedDRA10051094 Vascular access complicationLLTMedDRA10062169 Vascular access complicationPTCTCAE C78709 E12046 Vascular access complication Vascular disorders 10047065 Vascular disordersPTCTCAE E13855 Vascular disorders Vascular disorders - Other, specify Vascular disorders - Other, specifyPTCTCAE E13831 Vascular disorders - Other, specify Vasculitis 10047115 NCIA disorder characterized by inflammation involving the wall of a vessel. AngiitisLLTMedDRA10002369 Digital vasculitisLLTMedDRA10012994 Focal vasculitisLLTMedDRA10016844 PolyangiitisLLTMedDRA10036023 Vasculitis NOS aggravatedLLTMedDRA10047129 Vasculitis NOSLLTMedDRA10047128 Vasculitis aggravatedLLTMedDRA10047117 Vasculitis legsLLTMedDRA10047123 Vasculitis worsenedLLTMedDRA10047132 VasculitisLLTMedDRA10047115 VasculitisPTCTCAE C26912 E13837 Vasculitis Vasovagal reaction 10047166 NCIA disorder characterized by a sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the stimulation of the vagus nerve. Near faintingLLTMedDRA10066202 Near syncopeLLTMedDRA10066203 Orthostatic presyncopeLLTMedDRA10052495 Pre-syncopeLLTMedDRA10036507 PresyncopeLLTMedDRA10036653 Vagal reactionLLTMedDRA10046869 Vaso vagal attackLLTMedDRA10047138 Vasovagal attackLLTMedDRA10047165 Vasovagal reactionLLTMedDRA10047166 Vasovagal reactionPTCTCAE Vasovagal symptomsLLTMedDRA10047167 C50798 E12851 Vasovagal reaction Venous injury 10047228 NCIA finding of damage to a vein. Injury to anterior tibial veinLLTMedDRA10022134 Injury to axillary veinLLTMedDRA10022142 Injury to external jugular veinLLTMedDRA10022189 Injury to hepatic veinsLLTMedDRA10022203 Injury to hypogastric veinLLTMedDRA10022205 Injury to iliac veinLLTMedDRA10022209 Injury to inferior mesenteric veinLLTMedDRA10022212 Injury to innominate and subclavian veinsLLTMedDRA10022216 Injury to internal jugular veinLLTMedDRA10022219 Injury to jugular veinLLTMedDRA10065849 Injury to ovarian veinLLTMedDRA10022292 Injury to popliteal veinLLTMedDRA10022310 Injury to portal veinLLTMedDRA10022313 Injury to posterior tibial veinLLTMedDRA10022316 Injury to pulmonary veinLLTMedDRA10022321 Injury to renal veinLLTMedDRA10022329 Injury to splenic veinLLTMedDRA10022349 Injury to uterine veinLLTMedDRA10022386 Venous injuryLLTMedDRA10047228 Venous injuryPTCTCAE C78711 E12051 Venous injury Ventricular arrhythmia 10047281 NCIA disorder characterized by a dysrhythmia that originates in the ventricles. Arrhythmia ventricular (NOS)LLTMedDRA10003132 Arrhythmia ventricularLLTMedDRA10003131 Arrhythmic stormLLTMedDRA10067339 Malignant ventricular arrhythmiasLLTMedDRA10026707 Ventricular arrhythmia NOSLLTMedDRA10047282 Ventricular arrhythmiaLLTMedDRA10047281 Ventricular arrhythmiaPTCTCAE Ventricular rhythmLLTMedDRA10047297 C26924 E10230 Ventricular arrhythmia Ventricular fibrillation 10047290 NCIA disorder characterized by a dysrhythmia without discernible QRS complexes due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricles. Fibrillation paroxysmal ventLLTMedDRA10016571 Fibrillation ventricularLLTMedDRA10016573 Paroxysmal ventricular fibrillationLLTMedDRA10034048 Recurrent ventricular fibrillationLLTMedDRA10066685 Ventricular fibrillation paroxysmLLTMedDRA10047292 Ventricular fibrillation paroxysmalLLTMedDRA10047293 Ventricular fibrillationLLTMedDRA10047290 Ventricular fibrillationPTCTCAE C50799 E10236 Ventricular fibrillation Ventricular tachycardia 10047302 NCIA disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates distal to the bundle of His. Incessant ventricular tachycardiaLLTMedDRA10068441 Monomorphic ventricular tachycardiaLLTMedDRA10058185 Multifocal ventricular tachycardiaLLTMedDRA10028158 Multiform ventricular tachycardiaLLTMedDRA10028159 Non-sustained ventricular tachycardiaLLTMedDRA10060731 Paroxysmal VTLLTMedDRA10034050 Paroxysmal ventricular tachycardiaLLTMedDRA10034049 Polymorphic ventricular tachycardiaLLTMedDRA10036095 Recurrent sustained ventricular tachycardiaLLTMedDRA10066663 Recurrent ventricular tachycardiaLLTMedDRA10066686 Sustained ventricular tachycardiaLLTMedDRA10060730 Tachycardia paroxysmal ventricularLLTMedDRA10043082 Tachycardia ventricularLLTMedDRA10043085 Ventricular tachycardiaLLTMedDRA10047302 Ventricular tachycardiaPTCTCAE Wide complex ventricular tachycardiaLLTMedDRA10062524 C50802 E10239 Ventricular tachycardia Vertigo 10047340 NCIA disorder characterized by a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo). Acute rotatory vertigoLLTMedDRA10066744 Head revolving aroundLLTMedDRA10019201 Head revolving roundLLTMedDRA10019202 Head spinningLLTMedDRA10019203 Peripheral vertigo, unspecifiedLLTMedDRA10034641 Room going roundLLTMedDRA10039213 Rotatory vertigoLLTMedDRA10058708 Spinning sensationLLTMedDRA10041619 Vertiginous disorderLLTMedDRA10047338 Vertigo (excl dizziness)LLTMedDRA10047341 Vertigo aggravatedLLTMedDRA10047342 Vertigo objectiveLLTMedDRA10047346 Vertigo subjectiveLLTMedDRA10047349 VertigoLLTMedDRA10047340 VertigoPTCTCAE Vestibular vertigoLLTMedDRA10059614 C38057 E10291 Vertigo Vestibular disorder 10047386 NCIA disorder characterized by dizziness, imbalance, nausea, and vision problems. Disorder vestibularLLTMedDRA10013285 Vestibular abnormalitiesLLTMedDRA10047383 Vestibular disorder NOSLLTMedDRA10047387 Vestibular disorderLLTMedDRA10047386 Vestibular disorderPTCTCAE Vestibular function disorderLLTMedDRA10047388 Vestibular ischaemiaLLTMedDRA10063164 Vestibular ischemiaLLTMedDRA10063163 C27166 E10295 Vestibular disorder Virilization 10047488 NCIA disorder characterized by inappropriate masculinization occurring in a female or prepubertal male. MasculinisationLLTMedDRA10026858 MasculinizationLLTMedDRA10026859 VirilisationLLTMedDRA10056215 VirilismLLTMedDRA10047486 VirilizationLLTMedDRA10047488 VirilizationPTCTCAE C79859 E10343 Virilization Visceral arterial ischemia 10054692 NCIA disorder characterized by a decrease in blood supply due to narrowing or blockage of a visceral (mesenteric) artery. Visceral arterial ischaemiaLLTMedDRA10047503 Visceral arterial ischemiaLLTMedDRA10054692 Visceral arterial ischemiaPTCTCAE C78712 E13843 Visceral arterial ischemia Vital capacity abnormal 10047580 NCIA finding based on pulmonary function test results that indicate an abnormal vital capacity (amount of exhaled after a maximum inhalation) when compared to the predicted value. VC abnormalLLTMedDRA10047170 Vital capacity abnormal NOSLLTMedDRA10047581 Vital capacity abnormalLLTMedDRA10047580 Vital capacity abnormalPTCTCAE C78715 E12220 Vital capacity abnormal Vitreous hemorrhage 10047656 NCIA disorder characterized by blood extravasation into the vitreous humor. Vitreous haemorrhageLLTMedDRA10047655 Vitreous hemorrhageLLTMedDRA10047656 Vitreous hemorrhagePTCTCAE C50469 E10447 Vitreous hemorrhage Voice alteration 10047681 NCIA disorder characterized by a change in the sound and/or speed of the voice. Distorted voiceLLTMedDRA10013483 Disturbance in loudnessLLTMedDRA10013499 DysphoniaLLTMedDRA10013952 Hoarse voiceLLTMedDRA10020200 Hoarseness of voiceLLTMedDRA10020202 HoarsenessLLTMedDRA10020201 Phonation difficultyLLTMedDRA10034924 Resonance disorderLLTMedDRA10038641 Vocal tone disorderLLTMedDRA10047677 Vocal volume disorderLLTMedDRA10047678 Voice alterationLLTMedDRA10047681 Voice alterationPTCTCAE Voice disturbance, unspecifiedLLTMedDRA10047683 Voice disturbanceLLTMedDRA10047682 Voice loweredLLTMedDRA10047684 C61043 E13601 Voice alteration Vomiting 10047700 NCIA disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth. Bilious vomitingLLTMedDRA10004682 BlennemesisLLTMedDRA10058979 EmesisLLTMedDRA10014542 Habit vomitingLLTMedDRA10018804 HyperemesisLLTMedDRA10020613 Persistent vomitingLLTMedDRA10034716 Postprandial emesisLLTMedDRA10059851 Tablet in vomitusLLTMedDRA10052009 VomitedLLTMedDRA10047699 Vomiting NOSLLTMedDRA10047706 Vomiting aggravatedLLTMedDRA10048356 Vomiting of medicationLLTMedDRA10052008 Vomiting post chemotherapyLLTMedDRA10052401 VomitingLLTMedDRA10047700 VomitingPTCTCAE C3442 E11068 Vomiting Vulval infection 10065772 NCIA disorder characterized by an infectious process involving the vulva. Acute vulvitisLLTMedDRA10001110 Chronic vulvitisLLTMedDRA10009163 Labium majus pudendi purulenceLLTMedDRA10023535 Vulval infectionLLTMedDRA10065772 Vulval infectionPTCTCAE Vulval vestibulitisLLTMedDRA10056308 VulvitisLLTMedDRA10047780 C78716 E11629 Vulval infection Watering eyes 10047848 NCIA disorder of excessive tearing in the eyes; it can be caused by overproduction of tears or impaired drainage of the tear duct. Epiphora due to excess lacrimationLLTMedDRA10015069 Epiphora due to insufficient drainageLLTMedDRA10015070 Epiphora, unspecified as to causeLLTMedDRA10015071 EpiphoraLLTMedDRA10015068 Excess tearsLLTMedDRA10015591 Eyes tearingLLTMedDRA10016015 Lacrimation increasedLLTMedDRA10023644 LacrimationLLTMedDRA10023639 Tearing eyesLLTMedDRA10043171 Teary eyesLLTMedDRA10043172 Watering eyesLLTMedDRA10047848 Watering eyesPTCTCAE C78717 E10452 Watering eyes Weight gain 10047896 NCIA finding characterized by an increase in overall body weight; for pediatrics, greater than the baseline growth curve. Ponderal increasedLLTMedDRA10063441 Weight above normalLLTMedDRA10056815 Weight gainLLTMedDRA10047896 Weight gainPTCTCAE Weight increaseLLTMedDRA10047898 Weight increasedLLTMedDRA10047899 Wt gainLLTMedDRA10048060 C62754 E12224 Weight gain Weight loss 10047900 NCIA finding characterized by a decrease in overall body weight; for pediatrics, less than the baseline growth curve. Losing wtLLTMedDRA10024849 Loss of weightLLTMedDRA10024883 Lost weightLLTMedDRA10024886 Weight below normalLLTMedDRA10056816 Weight decreaseLLTMedDRA10047893 Weight decreasedLLTMedDRA10047895 Weight lossLLTMedDRA10047900 Weight lossPTCTCAE Wt lossLLTMedDRA10048061 C3445 E12228 Weight loss Wheezing 10047924 NCIA disorder characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways. Asthmatic wheezingLLTMedDRA10049200 Chronic wheezingLLTMedDRA10066689 Increased wheezinessLLTMedDRA10021694 SibilusLLTMedDRA10059257 Wheeze worsenedLLTMedDRA10047922 WheezeLLTMedDRA10047921 WheezesLLTMedDRA10047923 Wheezing aggravatedLLTMedDRA10048690 Wheezing expiratoryLLTMedDRA10047925 Wheezing inspiratoryLLTMedDRA10047926 WheezingLLTMedDRA10047924 WheezingPTCTCAE WheezyLLTMedDRA10047927 C78718 E13605 Wheezing White blood cell decreased 10049182 NCIA finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen. White blood cell decreasedPTCTCAE C26816 E12232 White blood cell decreased Wolff-Parkinson-White syndrome 10048015 NCIA disorder characterized by the presence of an accessory conductive pathway between the atria and the ventricles that causes premature ventricular activation. Wolff-Parkinson-White syndromePTCTCAE C35132 E10244 Wolff-Parkinson-White syndrome Wound complication 10053692 NCIA finding of development of a new problem at the site of an existing wound. Wound complicationLLTMedDRA10053692 Wound complicationPTCTCAE Wound edemaLLTMedDRA10062874 Wound erythemaLLTMedDRA10049543 Wound itchingLLTMedDRA10062873 Wound oedemaLLTMedDRA10062875 Wound painLLTMedDRA10049542 Wound tunnelingLLTMedDRA10067712 C78719 E12057 Wound complication Wound dehiscence 10048031 NCIA finding of separation of the approximated margins of a surgical wound. Wound dehiscenceLLTMedDRA10048031 Wound dehiscencePTCTCAE Wound surface unfoldedLLTMedDRA10048040 C50863 E12063 Wound dehiscence Wound infection 10048038 NCIA disorder characterized by an infectious process involving the wound. Post-traumatic wound infectionLLTMedDRA10036317 Wound infectionLLTMedDRA10048038 Wound infectionPTCTCAE C45234 E11635 Wound infection Wrist fracture 10048049 NCIA finding of traumatic injury to the wrist joint in which the continuity of a wrist bone is broken. Wrist fracturePTCTCAE C80517 E12069 Wrist fracture