Grant Details
| Grant Number: | 5P01CA089392-10 Interpret this number |
| Primary Investigator: | Bierut, Laura |
| Organization: | Washington University |
| Project Title: | The Collaborative Genetic Study of Nicotine Dependence |
| Fiscal Year: | 2012 |
Abstract
DESCRIPTION (provided by applicant): This application is for a 5-year renewal of the Collaborative Genetic Study of Nicotine Dependence. Through a genome wide association and candidate gene study, we successfully identified genes contributing to the development of nicotine dependence, such as the alpha5 nicotinic cholinergic receptor subunit, CHRNA5. The goals of this program are the further identification of genes, environmental features, and biological mechanisms that contribute to the onset and persistence of smoking and nicotine dependence. Project 1 builds upon the foundation laid in the past funding period. This project will use phenotypic refinement and sophisticated genetic modeling to analyze existing data, including the nicotine metabolism endophenotype. The goal of this project is to understand how genes affect the susceptibility to develop nicotine dependence and correlated characteristics. Project 2 will use a combination of genetic and functional approaches to further identify specific risk alleles. We will genotype the most significant SNPs from our previous study in an independent case control series. Genes that show evidence of replication will undergo fine mapping and those with the most compelling evidence of association will be examined in vivo and in vitro to determine functional consequences of the risk alleles. This will shed considerable light on the biological mechanisms underlying nicotine dependence. Project 3 adds a translational component to the program by incorporating mouse genetic models of Chrna5. This will identify and characterize reinforcing and aversive properties of nicotine exposure and basic neurobiological mechanisms through which Chrna5/alpha5 contributes to nicotine addiction. Project 4 examines questions central to understanding smoking cessation and relapse. The follow-up of nicotine dependent cases recruited during the past funding period will be the first longitudinal study of addicted smokers from a community based sample. We will test candidate genes for smoking cessation and relapse; test gene interactions; and test association between candidate genes and endophenotypes involved with cessation and relapse. Our synergistic program project uses a powerful trans-disciplinary approach to suggest novel strategies for reducing tobacco consumption and decreasing the morbidity and mortality that follow.
Publications
Dissection of the phenotypic and genotypic associations with nicotinic dependence.
Authors: Chen LS, Baker TB, Grucza R, Wang JC, Johnson EO, Breslau N, Hatsukami D, Smith SS, Saccone N, Saccone S, Rice JP, Goate AM, Bierut LJ
Source: Nicotine Tob Res, 2012 Apr;14(4), p. 425-33.
EPub date: 2011 Nov 18.
PMID: 22102629
Related Citations
Grant Numbers:
| NIDA NIH HHS - P50 DA019706 | PHS HHS - HHSN271200477451C | PHS HHS - GA305231 |
| PHS HHS - HHSN268200782096 | NHGRI NIH HHS - U01HG04422-02 | NCRR NIH HHS - KL2RR024994 |
| NCI NIH HHS - P01 CA89392 | PHS HHS - HHSN271200477471C | NCI NIH HHS - K05 CA139871 |
| NCI NIH HHS - P01 CA089392 |
Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence.
Authors: Haller G, Druley T, Vallania FL, Mitra RD, Li P, Akk G, Steinbach JH, Breslau N, Johnson E, Hatsukami D, Stitzel J, Bierut LJ, Goate AM
Source: Hum Mol Genet, 2012 Feb 1;21(3), p. 647-55.
EPub date: 2011 Oct 31.
PMID: 22042774
Related Citations
Grant Numbers:
| NIDA NIH HHS - R21 DA26918 | NCI NIH HHS - K08 CA140720 | PHS HHS - HHSN271200477451C |
| NCI NIH HHS - P01 CA089392-09 | NCI NIH HHS - P01 CA89392 |
MeSH Terms:
| Risk | Receptors, Nicotinic | Polymorphism, Single Nucleotide |
| Tobacco Use Disorder | Humans | HEK293 Cells |
| European Continental Ancestry Group | Adult | African Americans |
| Nerve Tissue Proteins | Male | Female |
Occupation and workplace policies predict smoking behaviors: analysis of national data from the current population survey.
Authors: Ham DC, Przybeck T, Strickland JR, Luke DA, Bierut LJ, Evanoff BA
Source: J Occup Environ Med, 2011 Nov;53(11), p. 1337-45.
PMID: 21988795
Related Citations
Grant Numbers:
| NIDA NIH HHS - K02 DA21237 | NIDA NIH HHS - K02 DA021237-02 | NCI NIH HHS - P50CA095815 |
| NCRR NIH HHS - UL1 RR024992-04 | NCI NIH HHS - P50 CA095815-02 | NCI NIH HHS - P01 CA89392 |
| NCI NIH HHS - P01 CA089392-03 | NCRR NIH HHS - UL1 RR024992 |
MeSH Terms:
| United States | Young Adult | Smoking |
| Organizational Policy | Humans | Adult |
| Middle Aged | Data Collection | Workplace |
| Adolescent | Male | Female |
DSM criteria for tobacco use disorder and tobacco withdrawal: a critique and proposed revisions for DSM-5.
Authors: Baker TB, Breslau N, Covey L, Shiffman S
Source: Addiction, 2012 Feb;107(2), p. 263-75.
PMID: 21919989
Related Citations
Grant Numbers:
| NCI NIH HHS - P01 CA089392-10 | NIDA NIH HHS - R01 DA020742-05 | NIDA NIH HHS - U10 DA01332-S3 |
| NIDA NIH HHS - U10 DA013035-09S3 | NIDA NIH HHS - R01 DA020742 | NCI NIH HHS - P01 CA89392 |
| NCI NIH HHS - K05 CA139871-03 | NIDA NIH HHS - P50DA019706-10 | NIDA NIH HHS - P50 DA019706-10 |
| NIDA NIH HHS - R01 DA02074 | NCI NIH HHS - K05 CA139871 |
MeSH Terms:
| Substance Withdrawal Syndrome | Reproducibility of Results | Tobacco Use Disorder |
| Humans | Time Factors | Psychometrics |
| Diagnostic and Statistical Manual of Mental Disorders |
Functional characterization of the ?5(Asn398) variant associated with risk for nicotine dependence in the ?3?4?5 nicotinic receptor.
Authors: Li P, McCollum M, Bracamontes J, Steinbach JH, Akk G
Source: Mol Pharmacol, 2011 Nov;80(5), p. 818-27.
EPub date: 2011 Aug 19.
PMID: 21856741
Related Citations
Grant Numbers:
| NCI NIH HHS - CA89392 | NIDA NIH HHS - DA26918 |
MeSH Terms:
| Receptors, Nicotinic | Polymorphism, Single Nucleotide | Patch-Clamp Techniques |
| Humans | Cell Line |
Cigarette smoking reduction and changes in nicotine dependence.
Authors: Mooney ME, Johnson EO, Breslau N, Bierut LJ, Hatsukami DK
Source: Nicotine Tob Res, 2011 Jun;13(6), p. 426-30.
EPub date: 2011 Mar 2.
PMID: 21367813
Related Citations
Grant Numbers:
| NIDA NIH HHS - K01-DA-019446 | NIDA NIH HHS - K01-DA-021237 | NCI NIH HHS - CA89392 |
| NCI NIH HHS - P01 CA089392 |
MeSH Terms:
| Smoking | Tobacco Use Disorder | Humans |
| Smoking Cessation | Adult | Retrospective Studies |
| Data Collection | Male | Female |
| Prevalence |
Meta-analysis of genome-wide association studies for personality.
Authors: de Moor MH, Costa PT, Terracciano A, Krueger RF, de Geus EJ, Toshiko T, Penninx BW, Esko T, Madden PA, Derringer J, Amin N, Willemsen G, Hottenga JJ, Distel MA, Uda M, Sanna S, Spinhoven P, Hartman CA, Sullivan P, Realo A, Allik J, Heath AC, Pergadia ML, Agrawal A, Lin P, Grucza R, Nutile T, Ciullo M, Rujescu D, Giegling I, Konte B, Widen E, Cousminer DL, Eriksson JG, Palotie A, Peltonen L, Luciano M, Tenesa A, Davies G, Lopez LM, Hansell NK, Medland SE, Ferrucci L, Schlessinger D, Montgomery GW, Wright MJ, Aulchenko YS, Janssens AC, Oostra BA, Metspalu A, Abecasis GR, Deary IJ, Räikkönen K, Bierut LJ, Martin NG, van Duijn CM, Boomsma DI
Source: Mol Psychiatry, 2012 Mar;17(3), p. 337-49.
EPub date: 2010 Dec 21.
PMID: 21173776
Related Citations
Grant Numbers:
| NIAAA NIH HHS - AA11998 | NHGRI NIH HHS - U01 HG004422-02 | NIAAA NIH HHS - U10 AA008401 |
| Wellcome Trust - 089062/Z/09/Z | Wellcome Trust - 89061/Z/09/Z | NCI NIH HHS - CA89392 |
| NIDA NIH HHS - R01 DA019963-02 | NIDA NIH HHS - R01 DA019963-03 | NIDA NIH HHS - R01 DA019963-01A2 |
| NHGRI NIH HHS - U01 HG004446 | NHGRI NIH HHS - U01 HG004422 | NIAAA NIH HHS - K05 AA017688-04 |
| NIMH NIH HHS - MH081802 | NIAAA NIH HHS - AA13321 | NIDA NIH HHS - R01 DA013423 |
| NIAAA NIH HHS - AA13320 | NIA NIH HHS - N01-AG-1-2109 | NIAAA NIH HHS - U10AA008401 |
| NCI NIH HHS - P01 CA089392-08 | NIAAA NIH HHS - AA07580 | NCI NIH HHS - P01 CA089392 |
| NHGRI NIH HHS - U01HG004438 | NIDA NIH HHS - R01 DA013423-05 | Biotechnology and Biological Sciences Research Council - null |
| NIDA NIH HHS - DA019951 | NIDA NIH HHS - DA12854 | NIDA NIH HHS - R01 DA012854-10 |
| NIAAA NIH HHS - AA07728 | Medical Research Council - null | NIMH NIH HHS - R01 MH059160 |
MeSH Terms:
Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence.
Authors: Culverhouse RC, Saccone NL, Stitzel JA, Wang JC, Steinbach JH, Goate AM, Schwantes-An TH, Grucza RA, Stevens VL, Bierut LJ
Source: Hum Genet, 2011 Feb;129(2), p. 177-88.
EPub date: 2010 Nov 16.
PMID: 21079997
Related Citations
Grant Numbers:
| NIDA NIH HHS - R03 DA023166-02 | NIDA NIH HHS - R03 DA023166 | NIGMS NIH HHS - K25 GM069590-05 |
| PHS HHS - HHSN271200477451C | PHS HHS - HHSN268200782096 | NCI NIH HHS - P01 CA089392-08 |
| NCI NIH HHS - P01 CA89392 | NIGMS NIH HHS - K25 GM69590 | PHS HHS - HHSN271200477471C |
MeSH Terms:
| Smoking | Receptors, Nicotinic | Polymorphism, Single Nucleotide |
| Logistic Models | Aged, 80 and over | Tobacco Use Disorder |
| Humans | Adult | Aged |
| Middle Aged | Male | Female |
The restricted partition method.
Authors: Culverhouse R
Source: Adv Genet, 2010;72, p. 117-39.
PMID: 21029851
Related Citations
Grant Numbers:
| NIDA NIH HHS - R03 DA023166 | NIGMS NIH HHS - K25 GM69590 | NCI NIH HHS - CA89392 |
MeSH Terms:
| Polymorphism, Single Nucleotide | Disease | Risk Factors |
| Models, Genetic | Humans | Genetic Association Studies |
| Algorithms | Genome-Wide Association Study |
Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.
Authors: Johnson EO, Chen LS, Breslau N, Hatsukami D, Robbins T, Saccone NL, Grucza RA, Bierut LJ
Source: Addiction, 2010 Nov;105(11), p. 2014-22.
EPub date: 2010 Sep 15.
PMID: 20840187
Related Citations
Grant Numbers:
| NCI NIH HHS - P01 CA089392-07 | PHS HHS - GA305231 | NHGRI NIH HHS - U01HG04422-02 |
| NCI NIH HHS - CA89392 | NCI NIH HHS - CA089392 |
MeSH Terms:
Genetics of addictions.
Authors: Hartz SM, Bierut LJ
Source: Clin Lab Med, 2010 Dec;30(4), p. 847-64.
PMID: 20832656
Related Citations
Grant Numbers:
MeSH Terms:
| Mental Disorders | Lung Neoplasms | Humans |
| Substance-Related Disorders | Genetic Association Studies | Pulmonary Disease, Chronic Obstructive |
Nicotinic ?5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms.
Authors: Smith RM, Alachkar H, Papp AC, Wang D, Mash DC, Wang JC, Bierut LJ, Sadee W
Source: Eur J Hum Genet, 2011 Jan;19(1), p. 76-83.
EPub date: 2010 Aug 11.
PMID: 20700147
Related Citations
Grant Numbers:
| NIDA NIH HHS - K02DA021237 | NIDA NIH HHS - R01 DA022199-04 | NIDA NIH HHS - DA022199 |
| NCI NIH HHS - P01 CA89392 | NIDA NIH HHS - K02 DA021237-05 |
MeSH Terms:
Genetics of addictions.
Authors: Hartz SM, Bierut LJ
Source: Psychiatr Clin North Am, 2010 Mar;33(1), p. 107-24.
PMID: 20159342
Related Citations
Grant Numbers:
MeSH Terms:
| Mental Disorders | Humans | Substance-Related Disorders |
| Gene Expression | Comorbidity | Genome-Wide Association Study |
Parental monitoring at age 11 and smoking initiation up to age 17 among Blacks and Whites: a prospective investigation.
Authors: Bohnert KM, Ríos-Bedoya CF, Breslau N
Source: Nicotine Tob Res, 2009 Dec;11(12), p. 1474-8.
EPub date: 2009 Nov 6.
PMID: 19897527
Related Citations
Grant Numbers:
| NIDA NIH HHS - DA021040 | NIMH NIH HHS - MH44586 | NCI NIH HHS - CA89392 |
MeSH Terms:
Association of CHRN genes with "dizziness" to tobacco.
Authors: Ehringer MA, McQueen MB, Hoft NR, Saccone NL, Stitzel JA, Wang JC, Bierut LJ
Source: Am J Med Genet B Neuropsychiatr Genet, 2010 Mar 5;153B(2), p. 600-9.
PMID: 19760673
Related Citations
Grant Numbers:
MeSH Terms:
| Polymorphism, Single Nucleotide | Dizziness | Humans |
| Phenotype | Smoking | Promoter Regions, Genetic |
| Receptors, Nicotinic | Haplotypes | RNA |
| Adult | Tobacco | Case-Control Studies |
| Female | Male |
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
Authors: Saccone NL, Wang JC, Breslau N, Johnson EO, Hatsukami D, Saccone SF, Grucza RA, Sun L, Duan W, Budde J, Culverhouse RC, Fox L, Hinrichs AL, Steinbach JH, Wu M, Rice JP, Goate AM, Bierut LJ
Source: Cancer Res, 2009 Sep 1;69(17), p. 6848-56.
EPub date: 2009 Aug 25.
PMID: 19706762
Related Citations
Grant Numbers:
| NHGRI NIH HHS - U01 HG004422-02 | NIAAA NIH HHS - K01 AA015572 | NIGMS NIH HHS - K25 GM069590-05 |
| NIDA NIH HHS - K02DA021237 | NIAAA NIH HHS - K01 AA015572-04 | NCI NIH HHS - P01 CA089392-079001 |
| PHS HHS - HHSN268200782096C | NCI NIH HHS - P01 CA089392-06A1 | NCI NIH HHS - P01 CA89392 |
| NIGMS NIH HHS - K25 GM69590 | PHS HHS - HHSN271200477471C | NCI NIH HHS - CA89392 |
| NIDA NIH HHS - R03 DA023166-02 | NIDA NIH HHS - R01 DA013423-05 | NIDA NIH HHS - R03 DA023166 |
| NCI NIH HHS - P01 CA089392-06A19002 | NIDA NIH HHS - R01 DA019963-03 | NIDA NIH HHS - K02 DA021237-03 |
| NIDA NIH HHS - R01DA019963 | NIDA NIH HHS - R01 DA026911-01 | NIDA NIH HHS - K01 DA024722-02 |
| NCI NIH HHS - P01 CA089392-06A10004 | NIDA NIH HHS - R01DA013423 | NIDA NIH HHS - K01DA024722 |
MeSH Terms:
Risky sexual behaviors and sexually transmitted diseases: a comparison study of cocaine-dependent individuals in treatment versus a community-matched sample.
Authors: Cavazos-Rehg PA, Spitznagel EL, Schootman M, Strickland JR, Afful SE, Cottler LB, Bierut LJ
Source: AIDS Patient Care STDS, 2009 Sep;23(9), p. 727-34.
PMID: 19645618
Related Citations
Grant Numbers:
| NIDA NIH HHS - K02 DA021237 | NIAAA NIH HHS - U10 AA008401 | NIAAA NIH HHS - AA12111 |
| NCRR NIH HHS - KL2 RR024994 | NIDA NIH HHS - R01 DA11622 | NCI NIH HHS - P01 CA89392 |
| NIDA NIH HHS - R21 DA19199 | NCRR NIH HHS - UL1 RR024992 | NCRR NIH HHS - KL2 RR024994-01 |
| NIMH NIH HHS - 2T32 MH17104-24 | NIDA NIH HHS - 5T32 DA07313-09 | NIDA NIH HHS - R01DA13423 |
| NIMH NIH HHS - T32 MH017104-24 | NIDA NIH HHS - R01 DA013423-01 | NIAAA NIH HHS - U10 AA008401-16 |
| NIDA NIH HHS - K02 DA021237-01A2 | NCRR NIH HHS - UL1 RR024992-01 |
MeSH Terms:
Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
Authors: Wang JC, Cruchaga C, Saccone NL, Bertelsen S, Liu P, Budde JP, Duan W, Fox L, Grucza RA, Kern J, Mayo K, Reyes O, Rice J, Saccone SF, Spiegel N, Steinbach JH, Stitzel JA, Anderson MW, You M, Stevens VL, Bierut LJ, Goate AM, COGEND collaborators and GELCC collaborators
Source: Hum Mol Genet, 2009 Aug 15;18(16), p. 3125-35.
EPub date: 2009 May 14.
PMID: 19443489
Related Citations
Grant Numbers:
| NIA NIH HHS - P50 AG05681 | PHS HHS - HHSN271200477451C | NCI NIH HHS - U01CA076293 |
| PHS HHS - HHSN268200782096 | NIAAA NIH HHS - U10AA008401 | NIAAA NIH HHS - R24 AA012725 |
| PHS HHS - HHSN271200477471C | NIA NIH HHS - P01 AG03991 | NCI NIH HHS - CA89392 |
MeSH Terms:
| Humans | Tobacco Use Disorder | Brain |
| Gene Expression | RNA, Messenger | Alleles |
| Receptors, Nicotinic | Lung Neoplasms | Risk Factors |
| Cohort Studies | Amino Acid Substitution | Female |
| Male |
Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.
Authors: Saccone NL, Saccone SF, Hinrichs AL, Stitzel JA, Duan W, Pergadia ML, Agrawal A, Breslau N, Grucza RA, Hatsukami D, Johnson EO, Madden PA, Swan GE, Wang JC, Goate AM, Rice JP, Bierut LJ
Source: Am J Med Genet B Neuropsychiatr Genet, 2009 Jun 5;150B(4), p. 453-66.
PMID: 19259974
Related Citations
Grant Numbers:
| NIDA NIH HHS - K01 DA015129 | NIAAA NIH HHS - K01 AA015572 | NIDA NIH HHS - K08 DA019951 |
| NIDA NIH HHS - R01 DA012854 | NIDA NIH HHS - K08 DA019951-04 | NIDA NIH HHS - R01 DA014369 |
| NCI NIH HHS - P01 CA89392 | NCI NIH HHS - P01 CA089392-05 |
MeSH Terms:
Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence.
Authors: Agrawal A, Pergadia ML, Balasubramanian S, Saccone SF, Hinrichs AL, Saccone NL, Breslau N, Johnson EO, Hatsukami D, Martin NG, Montgomery GW, Goate AM, Rice JP, Bierut LJ, Madden PA
Source: Addiction, 2009 Mar;104(3), p. 471-7.
PMID: 19207358
Related Citations
Grant Numbers:
| NIDA NIH HHS - K01 DA015129-05 | NIDA NIH HHS - DA012854 | PHS HHS - HHSN271200477451C |
| NIDA NIH HHS - K08 DA019951-04 | PHS HHS - HHSN271200477471C | NCI NIH HHS - CA89392 |
| NCI NIH HHS - P01 CA089392-05 | NIDA NIH HHS - DA21237 | NIDA NIH HHS - DA019951 |
| NIDA NIH HHS - K02 DA021237-02 | NIDA NIH HHS - R01 DA023668-02 | NIDA NIH HHS - K01DA015129 |
| NIDA NIH HHS - DA023668 | NIDA NIH HHS - R01 DA012854-05 |
MeSH Terms:
A testable prognostic model of nicotine dependence.
Authors: Ramoni RB, Saccone NL, Hatsukami DK, Bierut LJ, Ramoni MF
Source: J Neurogenet, 2009;23(3), p. 283-92.
EPub date: 2009 Jan 31.
PMID: 19184766
Related Citations
Grant Numbers:
MeSH Terms:
| Animals | Tobacco Use Disorder | Humans |
| Prognosis | Genetic Association Studies | Bayes Theorem |
| Models, Biological |
A comparison of association statistics between pooled and individual genotypes.
Authors: Knight J, Saccone SF, Zhang Z, Ballinger DG, Rice JP
Source: Hum Hered, 2009;67(4), p. 219-25.
EPub date: 2009 Jan 27.
PMID: 19172081
Related Citations
Grant Numbers:
| NIDA NIH HHS - DA012854 | Medical Research Council - G0501329 | PHS HHS - HHSN271200477471C |
| NCI NIH HHS - CA89392 |
MeSH Terms:
| Genotype | Polymorphism, Single Nucleotide | Genome, Human |
| Oligonucleotide Array Sequence Analysis | Gene Frequency | Humans |
| Models, Statistical | Computational Biology |
Race differences in nicotine dependence in the Collaborative Genetic study of Nicotine Dependence (COGEND).
Authors: Luo Z, Alvarado GF, Hatsukami DK, Johnson EO, Bierut LJ, Breslau N
Source: Nicotine Tob Res, 2008 Jul;10(7), p. 1223-30.
PMID: 18629733
Related Citations
Grant Numbers:
| NCI NIH HHS - CA89392 |
MeSH Terms:
Variants in nicotinic receptors and risk for nicotine dependence.
Authors: Bierut LJ, Stitzel JA, Wang JC, Hinrichs AL, Grucza RA, Xuei X, Saccone NL, Saccone SF, Bertelsen S, Fox L, Horton WJ, Breslau N, Budde J, Cloninger CR, Dick DM, Foroud T, Hatsukami D, Hesselbrock V, Johnson EO, Kramer J, Kuperman S, Madden PA, Mayo K, Nurnberger J Jr, Pomerleau O, Porjesz B, Reyes O, Schuckit M, Swan G, Tischfield JA, Edenberg HJ, Rice JP, Goate AM
Source: Am J Psychiatry, 2008 Sep;165(9), p. 1163-71.
EPub date: 2008 Jun 2.
PMID: 18519524
Related Citations
Grant Numbers:
| NIDA NIH HHS - K01 DA015129-05 | NIAAA NIH HHS - K01 AA015572 | NIDA NIH HHS - K01 DA016618-05 |
| NCI NIH HHS - P01 CA89392 | NIDA NIH HHS - R01 DA014369 | NIDA NIH HHS - K01 DA021237 |
| NIAAA NIH HHS - K01 AA015572-02 | NCI NIH HHS - P01 CA089392-05 | NIDA NIH HHS - K01 DA015129 |
| NIDA NIH HHS - R01 DA16618 | NIDA NIH HHS - R01 DA014369-05 | NIAAA NIH HHS - U10 AA-008401 |
| NIAAA NIH HHS - U10 AA008401-19 | NIDA NIH HHS - R01 DA02854 | NIDA NIH HHS - R01 DA012854-05 |
MeSH Terms:
Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study.
Authors: Agrawal A, Pergadia ML, Saccone SF, Hinrichs AL, Lessov-Schlaggar CN, Saccone NL, Neuman RJ, Breslau N, Johnson E, Hatsukami D, Montgomery GW, Heath AC, Martin NG, Goate AM, Rice JP, Bierut LJ, Madden PA
Source: Addiction, 2008 Jun;103(6), p. 1027-38.
PMID: 18482426
Related Citations
Grant Numbers:
| NIDA NIH HHS - DA019951 | NIDA NIH HHS - DA12854 | NIDA NIH HHS - K08 DA019951-03 |
| NIDA NIH HHS - K01DA015129 | NIDA NIH HHS - N01DA-0-7079 | PHS HHS - HHSN271200477471C |
| NIDA NIH HHS - DA015129 | NCI NIH HHS - CA89392 |
MeSH Terms:
| Behavior, Addictive | Evidence-Based Medicine | Humans |
| Tobacco Use Disorder | Receptors, GABA | Genotype |
| Phenotype | Chromosomes, Human, 4-5 | Logistic Models |
| Smoking Cessation | Case-Control Studies | Female |
| Male |
Drug use and dependence in cocaine dependent subjects, community-based individuals, and their siblings.
Authors: Bierut LJ, Strickland JR, Thompson JR, Afful SE, Cottler LB
Source: Drug Alcohol Depend, 2008 May 1;95(1-2), p. 14-22.
EPub date: 2008 Feb 19.
PMID: 18243582
Related Citations
Grant Numbers:
| NIDA NIH HHS - R01 DA013423-05 | NIDA NIH HHS - R01 DA013423-01S1 | NCRR NIH HHS - U10 RR008401 |
| NIDA NIH HHS - R01 DA013423-03 | NIDA NIH HHS - R01 DA013423-02S1 | NIDA NIH HHS - R01 DA013423-04 |
| NIDA NIH HHS - R01 DA 13423 | NIDA NIH HHS - R01 DA013423-01 | NCI NIH HHS - P01 CA89392 |
| NIDA NIH HHS - R01 DA013423-02 |
MeSH Terms:
Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample.
Authors: Agrawal A, Hinrichs AL, Dunn G, Bertelsen S, Dick DM, Saccone SF, Saccone NL, Grucza RA, Wang JC, Cloninger CR, Edenberg HJ, Foroud T, Hesselbrock V, Kramer J, Bucholz KK, Kuperman S, Nurnberger JI Jr, Porjesz B, Schuckit MA, Goate AM, Bierut LJ
Source: Drug Alcohol Depend, 2008 Jan 11;93(1-2), p. 12-20.
EPub date: 2007 Oct 17.
PMID: 17942244
Related Citations
Grant Numbers:
| NIAAA NIH HHS - U10 AA008401 | NIDA NIH HHS - DA019963 | NIDA NIH HHS - DA13423 |
| NIDA NIH HHS - R01 DA023668-01 | NHGRI NIH HHS - N01 HG65403 | NIAAA NIH HHS - U10 AA008401-04 |
| NIDA NIH HHS - R01 DA013423-01 | NCI NIH HHS - P01 CA89392 | NIDA NIH HHS - DA023668 |
MeSH Terms:
Analysis of [3',3'-d(2)]-nicotine and [3',3'-d(2)]-cotinine by capillary liquid chromatography-electrospray tandem mass spectrometry.
Authors: Murphy SE, Villalta P, Ho SW, von Weymarn LB
Source: J Chromatogr B Analyt Technol Biomed Life Sci, 2007 Sep 15;857(1), p. 1-8.
EPub date: 2007 Jun 29.
PMID: 17644451
Related Citations
Grant Numbers:
| NCI NIH HHS - CA77598 | NCI NIH HHS - P01 CA89392 | NCI NIH HHS - P01 CA089392-05 |
MeSH Terms:
Novel genes identified in a high-density genome wide association study for nicotine dependence.
Authors: Bierut LJ, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau OF, Swan GE, Rutter J, Bertelsen S, Fox L, Fugman D, Goate AM, Hinrichs AL, Konvicka K, Martin NG, Montgomery GW, Saccone NL, Saccone SF, Wang JC, Chase GA, Rice JP, Ballinger DG
Source: Hum Mol Genet, 2007 Jan 1;16(1), p. 24-35.
EPub date: 2006 Dec 7.
PMID: 17158188
Related Citations
Grant Numbers:
| NIDA NIH HHS - DA12854 | NIDA NIH HHS - N01DA-0-7079 | NCI NIH HHS - P01 CA089392-05 |
| NIDA NIH HHS - DA015129 | NCI NIH HHS - CA89392 |
MeSH Terms:
| Genotype | Smoking | Polymorphism, Single Nucleotide |
| Genome, Human | Gene Frequency | Tobacco Use Disorder |
| Humans | Case-Control Studies | Genetic Predisposition to Disease |
| Male | Female |
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.
Authors: Saccone SF, Hinrichs AL, Saccone NL, Chase GA, Konvicka K, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau O, Swan GE, Goate AM, Rutter J, Bertelsen S, Fox L, Fugman D, Martin NG, Montgomery GW, Wang JC, Ballinger DG, Rice JP, Bierut LJ
Source: Hum Mol Genet, 2007 Jan 1;16(1), p. 36-49.
EPub date: 2006 Nov 29.
PMID: 17135278
Related Citations
Grant Numbers:
| NIDA NIH HHS - DA12854 | NIDA NIH HHS - N01DA-0-7079 | NCI NIH HHS - P01 CA089392-05 |
| NIDA NIH HHS - DA015129 | NCI NIH HHS - CA89392 |
MeSH Terms:
