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Grant Details

Grant Number: 7U19CA148127-03 Interpret this number
Primary Investigator: Amos, Christopher
Organization: Dartmouth College
Project Title: Transdisciplinary Research in Cancer of the Lung (TRICL)
Fiscal Year: 2012
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Abstract

Lung cancer is the leading cause of cancer-related mortality in the U.S. and the world. The genetic factors that commonly influence lung cancer susceptibility have not yet been investigated thoroughly, but eight genome-wide association studies have been performed. In area 1 of our response, we propose to integrate data from these eight studies that comprise over 13,000 lung cancer cases and 25,000 controls to increase power to detect genetic factors influencing all types of lung cancer and to allow us to analyze specific subsets, such as cases with early onset, specific histological sets, gender-defined groups and never smokers and the extended sample size will allow us to study gene-environment interactions. Existing genome-wide association studies have not analyzed data from nonCaucasian ethnic backgrounds and we therefore propose characterizing and fine mapping genetic factoid In 1500 African-American and 1500 Asian case-control pairs along with an additional 3000 Caucasian case-control pairs. We will then replicate our findings in a broader collection of an additional 12,000 case-control pairs. In area 2, we will evaluate genes in specific loci including nicotinic acetycholine receptor subunits CHRNA5 and CHRNA3 for the effiects that identified SNPs from area 1 have upon these genes functions. We will also study several other loci that have been identified through existing GWAS as strongly associated with lung cancer risk, including PSMA4, hTERT, CLPT1 ML, BAT3, and hMSHS. For each of these genes, we will study modulation of these genes using cellular models relevant to their known functions. In area 3, we propose epidemiological characterization of genetic and environmental risk factors for lung cancer. We will characterize mechanisms by which variation in the loci identified in area 1 influence risk, in conjunction with smoking and other exposures. We will also evaluate the calibration of existing risk prediction models for lung cancer and then develop new models based upon genetic and environmental data from this initiative. The overarching goal of our proposal is the identification of individuals at high risk for lung cancer development for whom screening and early detection would be most beneficial in reducing the burden of lung cancer.

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Publications

Genomic sequencing in cancer.
Authors: Tuna M, Amos CI
Source: Cancer Lett, 2012 Nov 23;null, p. null.
EPub date: 2012 Nov 23.
PMID: 23178448
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Grant Numbers:
NCI NIH HHS - U19 CA148127 NCI NIH HHS - P30 CA016672

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Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer.
Authors: Wang LE, Gorlova OY, Ying J, Qiao Y, Weng SF, Lee AT, Gregersen PK, Spitz MR, Amos CI, Wei Q
Source: Cancer Res, 2013 Jan 1;73(1), p. 256-64.
EPub date: 2012 Oct 29.
PMID: 23108145
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Grant Numbers:
NCI NIH HHS - R01 CA121197 NCI NIH HHS - R01 CA055769 NCI NIH HHS - R01 CA074851
NCI NIH HHS - R01CA131274 NIEHS NIH HHS - R01ES011740 NCI NIH HHS - R01CA055769
NCI NIH HHS - P30CA016672 NCI NIH HHS - R01CA127219 NCI NIH HHS - R01 CA131274
NCI NIH HHS - U19CA148127 NCI NIH HHS - R01CA121197 NCI NIH HHS - R01CA149462
NIEHS NIH HHS - R01 ES011740

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Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.
Authors: Jin G, Ma H, Wu C, Dai J, Zhang R, Shi Y, Lu J, Miao X, Wang M, Zhou Y, Chen J, Li H, Pan S, Chu M, Lu F, Yu D, Jiang Y, Dong J, Hu L, Chen Y, Xu L, Shu Y, Pan S, Tan W, Zhou B, Lu D, Wu T, Zhang Z, Chen F, Wang X, Hu Z, Lin D, Shen H
Source: Am J Hum Genet, 2012 Nov 2;91(5), p. 928-34.
EPub date: 2012 Oct 25.
PMID: 23103227
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Grant Numbers:
NCI NIH HHS - U19 CA148127

MeSH Terms:
Genetic Variation Esophageal Neoplasms Humans
Neoplasms, Multiple Primary Aged Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 7 Genome-Wide Association Study Asian Continental Ancestry Group
Risk Lung Neoplasms Stomach Neoplasms
Middle Aged Genetic Predisposition to Disease Carcinoma, Squamous Cell
Male China Female

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Genetic association analysis of complex diseases incorporating intermediate phenotype information.
Authors: Li Y, Huang J, Amos CI
Source: PLoS One, 2012;7(10), p. e46612.
EPub date: 2012 Oct 19.
PMID: 23094028
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Grant Numbers:
NCI NIH HHS - U19 CA148127 NCI NIH HHS - P50CA70907 NCI NIH HHS - P30CA016772
NCI NIH HHS - R01CA121197

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Method for evaluating multiple mediators: mediating effects of smoking and COPD on the association between the CHRNA5-A3 variant and lung cancer risk.
Authors: Wang J, Spitz MR, Amos CI, Wu X, Wetter DW, Cinciripini PM, Shete S
Source: PLoS One, 2012;7(10), p. e47705.
EPub date: 2012 Oct 15.
PMID: 23077662
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Grant Numbers:
NCI NIH HHS - R01CA131324 NCI NIH HHS - R01 CA131324 NCI NIH HHS - U19CA148127
NCI NIH HHS - R01CA121197

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Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4.
Authors: Scherf DB, Sarkisyan N, Jacobsson H, Claus R, Bermejo JL, Peil B, Gu L, Muley T, Meister M, Dienemann H, Plass C, Risch A
Source: Oncogene, 2012 Sep 3;null, p. null.
EPub date: 2012 Sep 3.
PMID: 22945651
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Grant Numbers:
NCI NIH HHS - U19 CA148127

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Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.
Authors: Timofeeva MN, Hung RJ, Rafnar T, Christiani DC, Field JK, Bickeböller H, Risch A, McKay JD, Wang Y, Dai J, Gaborieau V, McLaughlin J, Brenner D, Narod SA, Caporaso NE, Albanes D, Thun M, Eisen T, Wichmann HE, Rosenberger A, Han Y, Chen W, Zhu D, Spitz M, Wu X, Pande M, Zhao Y, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Krokan HE, Gabrielsen ME, Skorpen F, Vatten L, Njølstad I, Chen C, Goodman G, Lathrop M, Benhamou S, Vooder T, Välk K, Nelis M, Metspalu A, Raji O, Chen Y, Gosney J, Liloglou T, Muley T, Dienemann H, Thorleifsson G, Shen H, Stefansson K, Brennan P, Amos CI, Houlston R, Landi MT, Transdisciplinary Research in Cancer of the Lung (TRICL) Research Team
Source: Hum Mol Genet, 2012 Nov 15;21(22), p. 4980-95.
EPub date: 2012 Aug 16.
PMID: 22899653
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Grant Numbers:
NCI NIH HHS - N01-CN-25518 Cancer Research UK - C1298/A8362 NCI NIH HHS - 5R01CA121197
NCI NIH HHS - 5R01CA055769 NCI NIH HHS - N01-CN-25514 NHLBI NIH HHS - R01HL091172-01
NCI NIH HHS - N01-CN-25515 NCI NIH HHS - N01-CN-25516 CCR NIH HHS - N01-RC-37004
NCI NIH HHS - N01-CN-75022 Cancer Research UK - C1298/A8780 NCI NIH HHS - P50 CA70907
NCI NIH HHS - R01 CA111703 NCI NIH HHS - N01-CN-25511 NCI NIH HHS - U19CA148127
NCI NIH HHS - R01 CA092039 NHGRI NIH HHS - U01 HG004446 NCI NIH HHS - N01-CN-25513
NHGRI NIH HHS - HG-06033-01 NCI NIH HHS - N01-CN-25512 NCI NIH HHS - R01CA121197
NCI NIH HHS - CA090578 NCI NIH HHS - N01-CN-25404 NCI NIH HHS - 5R01CA127219
NCI NIH HHS - R01 CA127219 NCI NIH HHS - U01 CA63673 NCI NIH HHS - CA092824
CCR NIH HHS - N01-RC-45035 NCI NIH HHS - N01-CN-45165 NCI NIH HHS - CA074386
NCI NIH HHS - U19 CA148127 NHGRI NIH HHS - U01HG004438 NCI NIH HHS - 5R01CA133996
NCI NIH HHS - R01 CA55769 NCI NIH HHS - N01-CN-25476 NCI NIH HHS - N01-CN-25524
NCI NIH HHS - N01-CN-25522

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Natural and orthogonal interaction framework for modeling gene-environment interactions with application to lung cancer.
Authors: Ma J, Xiao F, Xiong M, Andrew AS, Brenner H, Duell EJ, Haugen A, Hoggart C, Hung RJ, Lazarus P, Liu C, Matsuo K, Mayordomo JI, Schwartz AG, Staratschek-Jox A, Wichmann E, Yang P, Amos CI
Source: Hum Hered, 2012;73(4), p. 185-94.
EPub date: 2012 Aug 9.
PMID: 22889990
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Grant Numbers:
NCI NIH HHS - U19 CA148127 NHLBI NIH HHS - R01 HL106034 NCI NIH HHS - CA134682
NCI NIH HHS - R01 CA121197 NCI NIH HHS - P01 CA034936 NCI NIH HHS - P30 CA016672
NCI NIH HHS - R01 CA133996 PHS HHS - RP100443 NCI NIH HHS - CA121197
NCI NIH HHS - R01CA134682 NIAMS NIH HHS - R01AR057120 NIAMS NIH HHS - R01 AR057120

MeSH Terms:
Polymorphism, Single Nucleotide Computer Simulation Gene Frequency
Genetic Loci Genetics, Population Humans
Genome-Wide Association Study Quantitative Trait, Heritable Smoking
Logistic Models Lung Neoplasms Models, Genetic
Case-Control Studies Databases, Factual Early Detection of Cancer
Gene-Environment Interaction Genetic Predisposition to Disease

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Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.
Authors: Hu L, Wu C, Zhao X, Heist R, Su L, Zhao Y, Han B, Cao S, Chu M, Dai J, Dong J, Shu Y, Xu L, Chen Y, Wang Y, Lu F, Jiang Y, Yu D, Chen H, Tan W, Ma H, Chen J, Jin G, Wu T, Lu D, Christiani DC, Lin D, Hu Z, Shen H
Source: Clin Cancer Res, 2012 Oct 1;18(19), p. 5507-14.
EPub date: 2012 Aug 7.
PMID: 22872573
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Grant Numbers:
NCI NIH HHS - U19-CA148127-01 NCI NIH HHS - CA092824-0

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Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.
Authors: Hartz SM, Short SE, Saccone NL, Culverhouse R, Chen L, Schwantes-An TH, Coon H, Han Y, Stephens SH, Sun J, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Geller F, Gubjartsson D, Hansel NN, Jiang C, Keskitalo-Vuokko K, Liu Z, Lyytikäinen LP, Michel M, Rawal R, Rosenberger A, Scheet P, Shaffer JR, Teumer A, Thompson JR, Vink JM, Vogelzangs N, Wenzlaff AS, Wheeler W, Xiao X, Yang BZ, Aggen SH, Balmforth AJ, Baumeister SE, Beaty T, Bennett S, Bergen AW, Boyd HA, Broms U, Campbell H, Chatterjee N, Chen J, Cheng YC, Cichon S, Couper D, Cucca F, Dick DM, Foroud T, Furberg H, Giegling I, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Hayward C, Heikkilä K, Hewitt JK, Hottenga JJ, Jensen MK, Jousilahti P, Kaakinen M, Kittner SJ, Konte B, Korhonen T, Landi MT, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Muley T, Murray T, Nauck M, North K, Pergadia M, Polasek O, Ramos EM, Ripatti S, Risch A, Ruczinski I, Rudan I, Salomaa V, Schlessinger D, Styrkársdóttir U, Terracciano A, Uda M, Willemsen G, Wu X, Abecasis G, Barnes K, Bickeböller H, Boerwinkle E, Boomsma DI, Caporaso N, Duan J, Edenberg HJ, Francks C, Gejman PV, Gelernter J, Grabe HJ, Hops H, Jarvelin MR, Viikari J, Kähönen M, Kendler KS, Lehtimäki T, Levinson DF, Marazita ML, Marchini J, Melbye M, Mitchell BD, Murray JC, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Sanders AR, Schwartz AG, Shete S, Shi J, Spitz M, Stefansson K, Swan GE, Thorgeirsson T, Völzke H, Wei Q, Wichmann HE, Amos CI, Breslau N, Cannon DS, Ehringer M, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Stitzel JA, Weiss RB, Kraft P, Bierut LJ
Source: Arch Gen Psychiatry, 2012 Aug;69(8), p. 854-60.
PMID: 22868939
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Grant Numbers:
NIAAA NIH HHS - R01 AA017535 NIAAA NIH HHS - U10 AA008401 NIMH NIH HHS - R01 MH60879
NCRR NIH HHS - TL1 RR024995 NIA NIH HHS - R03 AG035146 PHS HHS - HHSN268200782096C
NIMH NIH HHS - R01 MH60870 NCRR NIH HHS - UL1 RR024992 NCRR NIH HHS - U54 RR020278
NCI NIH HHS - N01-PC35145 NCI NIH HHS - N01-PC35146 NIDA NIH HHS - R21DA033827
NCI NIH HHS - K07 CA118412 NHGRI NIH HHS - U01 HG004446 NHLBI NIH HHS - N01-HR-46002
NHGRI NIH HHS - U01HG004446 NIDCR NIH HHS - U01-DE018903 NIMH NIH HHS - U01 MH046318-08
NHGRI NIH HHS - U01HG004738 NIDA NIH HHS - R01 DA012849 NIDA NIH HHS - R01 DA012690
NIMH NIH HHS - R01 MH59588 NIDCR NIH HHS - U01 DE018903 NIAAA NIH HHS - R01 AA11330
NIMH NIH HHS - R01 MH081800 NIMH NIH HHS - R01 MH59587 NCRR NIH HHS - KL2 RR024994
NIMH NIH HHS - R01 MH59586 NIMH NIH HHS - R01 MH81800 NIA NIH HHS - N01-AG-1-2109
NCATS NIH HHS - KL2 TR000450 NIMH NIH HHS - R01 MH059586 NIAAA NIH HHS - R01 AA011330
NHGRI NIH HHS - U01 HG004738 NIDA NIH HHS - K01 DA024758 NCATS NIH HHS - UL1 TR000448
NHGRI NIH HHS - U01 HG004436 NIDA NIH HHS - DA12854 NIDA NIH HHS - K01DA19498
NIDA NIH HHS - R01 DA12849 NIMH NIH HHS - U01 MH079469 NIDA NIH HHS - K02DA021237
NINDS NIH HHS - U01 NS069208 NIMH NIH HHS - R01 MH59571 NIDA NIH HHS - R01DA026911
NIDA NIH HHS - R21DA027070 NCRR NIH HHS - UL1RR024992 NIMH NIH HHS - MH46318
NCI NIH HHS - R01CA060691 NIMH NIH HHS - U01 MH79470 NIMH NIH HHS - R01 MH059571
NIMH NIH HHS - U01 MH46276 NIDA NIH HHS - R01 DA12690 NIDA NIH HHS - R01 DA03706
NIMH NIH HHS - U01 MH079470 NIDA NIH HHS - R01 DA003706 NIDA NIH HHS - U01DA02830
NIDA NIH HHS - K02 DA021237 NIMH NIH HHS - R01 MH59565 NIAAA NIH HHS - K02 AA018755
NHLBI NIH HHS - R01HL089651-01 NIDA NIH HHS - R01DA25888 NIDA NIH HHS - R01 DA025888
NIMH NIH HHS - R01 MH59566 NIMH NIH HHS - R01 MH67257 NIDA NIH HHS - R01 DA012854
NINDS NIH HHS - R01NS45012 NIMH NIH HHS - U01 MH79469 NCI NIH HHS - P01 CA089392
NINDS NIH HHS - R01 NS045012 NCI NIH HHS - U19 CA148127 NHGRI NIH HHS - U01HG004438
NIMH NIH HHS - T32 MH014677 NIMH NIH HHS - R01 MH61675 NIMH NIH HHS - R01 MH059566
NIMH NIH HHS - R01 MH059565 NIDA NIH HHS - DA019951 NIDA NIH HHS - K01DA24758
NIDA NIH HHS - R01 DA017932 NIMH NIH HHS - MH46289 NCATS NIH HHS - TL1 TR000449

MeSH Terms:
Severity of Illness Index Polymorphism, Single Nucleotide Age of Onset
Tobacco Use Disorder Humans Genetic Association Studies
Europe Adolescent Development Nerve Tissue Proteins
Smoking Receptors, Nicotinic Nicotine
Adult Gene-Environment Interaction Genetic Predisposition to Disease
Adolescent Female Male

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The influence of race and ethnicity on the biology of cancer.
Authors: Henderson BE, Lee NH, Seewaldt V, Shen H
Source: Nat Rev Cancer, 2012 Sep;12(9), p. 648-53.
EPub date: 2012 Aug 2.
PMID: 22854838
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Grant Numbers:
NCI NIH HHS - U19 CA148127 NCI NIH HHS - CA148537 NIDDK NIH HHS - DK056108
NCI NIH HHS - CA054281 NCI NIH HHS - CA136792 NCI NIH HHS - CA120316

MeSH Terms:
Neoplasms Risk Factors Humans
Incidence Genomics

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Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population.
Authors: Dong J, Hu Z, Wu C, Guo H, Zhou B, Lv J, Lu D, Chen K, Shi Y, Chu M, Wang C, Zhang R, Dai J, Jiang Y, Cao S, Qin Z, Yu D, Ma H, Jin G, Gong J, Sun C, Zhao X, Yin Z, Yang L, Li Z, Deng Q, Wang J, Wu W, Zheng H, Zhou G, Chen H, Guan P, Peng Z, Chen Y, Shu Y, Xu L, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y, Zhang H, Yan Y, Amos CI, Chen F, Tan W, Jin L, Wu T, Lin D, Shen H
Source: Nat Genet, 2012 Jul 15;44(8), p. 895-9.
EPub date: 2012 Jul 15.
PMID: 22797725
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Grant Numbers:
NCI NIH HHS - U19 CA148127

MeSH Terms:
Polymorphism, Single Nucleotide Humans Muscle Proteins
GATA3 Transcription Factor Nerve Tissue Proteins Genome-Wide Association Study
Asian Continental Ancestry Group Protein Phosphatase 2 Smoking
Lung Neoplasms Case-Control Studies Steroid Hydroxylases
Genetic Predisposition to Disease China

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Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus.
Authors: James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J, You M
Source: PLoS One, 2012;7(6), p. e36116.
EPub date: 2012 Jun 4.
PMID: 22675468
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Grant Numbers:
NCI NIH HHS - U19CA148127 NCI NIH HHS - #P30 CA91842

MeSH Terms:
Mutagens Apoptosis Genetic Loci
DNA Damage Humans Genetic Association Studies
Cell Line, Tumor Drug Resistance, Neoplasm Membrane Proteins
bcl-X Protein Chromosomes, Human, Pair 5 Gene Expression Regulation, Neoplastic
Neoplasm Proteins Lung Neoplasms Risk Factors
Genetic Predisposition to Disease Adenocarcinoma

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Genome-wide gene-environment interaction analysis for asbestos exposure in lung cancer susceptibility.
Authors: Wei S, Wang LE, McHugh MK, Han Y, Xiong M, Amos CI, Spitz MR, Wei QW
Source: Carcinogenesis, 2012 Aug;33(8), p. 1531-7.
EPub date: 2012 May 27.
PMID: 22637743
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Grant Numbers:
NCI NIH HHS - U19 CA148127 NCI NIH HHS - R01CA127219 NHLBI NIH HHS - R01 HL106034
NCI NIH HHS - P30 CA016672 NIEHS NIH HHS - R01ES011740 NCI NIH HHS - R01CA131274
NCI NIH HHS - R01CA055769 NCI NIH HHS - CA121197 NIAMS NIH HHS - R01 AR057120

MeSH Terms:
Polymorphism, Single Nucleotide Asbestos Genome, Human
Lung Neoplasms Humans Aged
Middle Aged Genetic Predisposition to Disease Male
Female

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Variants in inflammation genes are implicated in risk of lung cancer in never smokers exposed to second-hand smoke.
Authors: Spitz MR, Gorlov IP, Amos CI, Dong Q, Chen W, Etzel CJ, Gorlova OY, Chang DW, Pu X, Zhang D, Wang L, Cunningham JM, Yang P, Wu X
Source: Cancer Discov, 2011 Oct;1(5), p. 420-9.
EPub date: 2011 Aug 25.
PMID: 22586632
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Grant Numbers:
NCI NIH HHS - CA149462 NCI NIH HHS - CA131327 NCI NIH HHS - CA80127
NCI NIH HHS - CA55769 NCI NIH HHS - CA84354 NCI NIH HHS - CA127219
NCI NIH HHS - U19CA148127 NCI NIH HHS - CA121197 NCI NIH HHS - CA123235

MeSH Terms:
Tobacco Smoke Pollution Activin Receptors, Type I Genetic Variation
Polymorphism, Single Nucleotide Cocarcinogenesis Airway Remodeling
Humans Inflammation Genotype
Lung Neoplasms Risk Factors Case-Control Studies
Middle Aged Genetic Predisposition to Disease Adenocarcinoma
Carcinoma, Non-Small-Cell Lung Nuclear Receptor Subfamily 4, Group A, Member 1 Male
Female

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Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma.
Authors: Shi J, Chatterjee N, Rotunno M, Wang Y, Pesatori AC, Consonni D, Li P, Wheeler W, Broderick P, Henrion M, Eisen T, Wang Z, Chen W, Dong Q, Albanes D, Thun M, Spitz MR, Bertazzi PA, Caporaso NE, Chanock SJ, Amos CI, Houlston RS, Landi MT
Source: Cancer Discov, 2012 Feb;2(2), p. 131-9.
EPub date: 2011 Dec 7.
PMID: 22585858
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Grant Numbers:
NCI NIH HHS - R01 CA127219 NCI NIH HHS - ZIA CP010200-04 Cancer Research UK - C1298/A8362
NHLBI NIH HHS - R01HL091172-01 NCI NIH HHS - U19CA121197 PHS HHS - HHSN268200782096C
Cancer Research UK - C1298/A8780 NHGRI NIH HHS - U01HG004438 NCI NIH HHS - U19 CA14812701
PHS HHS - HG-06-033-NCI-01 NCI NIH HHS - R01CA55769 NHGRI NIH HHS - U01HG004446
NCI NIH HHS - R01CA133996

MeSH Terms:
Genetic Variation Polymorphism, Single Nucleotide Humans
Texas Rad52 DNA Repair and Recombination Protein Chromosomes, Human, Pair 12
Great Britain Genome-Wide Association Study Smoking
Lung Neoplasms Cohort Studies Case-Control Studies
Genetic Predisposition to Disease Carcinoma, Squamous Cell Carcinoma, Non-Small-Cell Lung

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Multistage analysis of variants in the inflammation pathway and lung cancer risk in smokers.
Authors: Spitz MR, Gorlov IP, Dong Q, Wu X, Chen W, Chang DW, Etzel CJ, Caporaso NE, Zhao Y, Christiani DC, Brennan P, Albanes D, Shi J, Thun M, Landi MT, Amos CI
Source: Cancer Epidemiol Biomarkers Prev, 2012 Jul;21(7), p. 1213-21.
EPub date: 2012 May 9.
PMID: 22573796
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Grant Numbers:
NCI NIH HHS - U19 CA148127 NCI NIH HHS - R01CA127219 NCI NIH HHS - R01 CA127219
NCI NIH HHS - P01CA090578 NCI NIH HHS - R01CA074386 NCI NIH HHS - P50 CA070907
NCI NIH HHS - R01CA55769 NCI NIH HHS - CA121197

MeSH Terms:
Interleukin-2 Receptor beta Subunit Polymorphism, Single Nucleotide Humans
Prognosis Aged Genome-Wide Association Study
Inflammation Genotype Smoking
Proto-Oncogene Proteins c-bcl-2 Survival Rate Lung Neoplasms
Risk Factors Adult Case-Control Studies
Middle Aged Adenocarcinoma Female
Male

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Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25.
Authors: Chen LS, Saccone NL, Culverhouse RC, Bracci PM, Chen CH, Dueker N, Han Y, Huang H, Jin G, Kohno T, Ma JZ, Przybeck TR, Sanders AR, Smith JA, Sung YJ, Wenzlaff AS, Wu C, Yoon D, Chen YT, Cheng YC, Cho YS, David SP, Duan J, Eaton CB, Furberg H, Goate AM, Gu D, Hansen HM, Hartz S, Hu Z, Kim YJ, Kittner SJ, Levinson DF, Mosley TH, Payne TJ, Rao DC, Rice JP, Rice TK, Schwantes-An TH, Shete SS, Shi J, Spitz MR, Sun YV, Tsai FJ, Wang JC, Wrensch MR, Xian H, Gejman PV, He J, Hunt SC, Kardia SL, Li MD, Lin D, Mitchell BD, Park T, Schwartz AG, Shen H, Wiencke JK, Wu JY, Yokota J, Amos CI, Bierut LJ
Source: Genet Epidemiol, 2012 May;36(4), p. 340-51.
PMID: 22539395
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Grant Numbers:
NIMH NIH HHS - R01 MH60879 NHLBI NIH HHS - R01 HL068737 NIMH NIH HHS - R01 MH60870
NIMH NIH HHS - U01 MH46318 NHLBI NIH HHS - N01 HC055021 NHLBI NIH HHS - N01 HC055020
NIDA NIH HHS - K08DA030398 NIMH NIH HHS - R01 MH061675 NHGRI NIH HHS - U01 HG004402
NHGRI NIH HHS - U01HG004402 NIDA NIH HHS - R21DA033827 NCI NIH HHS - U19CA148127
WHI NIH HHS - N01WH22110 NCRR NIH HHS - UL1RR025005 NHLBI NIH HHS - N01HC55022
NIMH NIH HHS - R01 MH081800 NCRR NIH HHS - KL2 RR024994 NHLBI NIH HHS - HL54515
WHI NIH HHS - N01 WH032122 NHLBI NIH HHS - HL54509 PHS HHS - 32108-9
WHI NIH HHS - N01 WH032119 WHI NIH HHS - N01 WH032118 NHLBI NIH HHS - HL54457
NHLBI NIH HHS - R01HL59367 NCI NIH HHS - R01 CA052689 NCI NIH HHS - R01CA133996
NIDA NIH HHS - R03DA023166 NIDA NIH HHS - K08 DA030398 NIDA NIH HHS - R01 DA017441
NINDS NIH HHS - U01 NS069208 PHS HHS - 24152 PHS HHS - RP10043
NCI NIH HHS - R01CA127219 NIDA NIH HHS - R01 DA026911 NIMH NIH HHS - R01 MH059571
NCI NIH HHS - P50 CA070907 WHI NIH HHS - N01 WH042129 PHS HHS - HHSN268200782096
NCRR NIH HHS - KL2RR024994 NHGRI NIH HHS - U01 HG04422-01 NIDA NIH HHS - K02 DA021237
NINDS NIH HHS - U01 NS069208-01 NCI NIH HHS - R01 CA055769 WHI NIH HHS - N01 WH024152
NHLBI NIH HHS - R01 HL059367 NHLBI NIH HHS - HL087660 NCI NIH HHS - P30CA16672
NCI NIH HHS - R01 CA060691 NIMH NIH HHS - R01 MH67257 NINDS NIH HHS - R01 NS045012
NIMH NIH HHS - R01 MH61675 NIEHS NIH HHS - R01 ES06717 NIMH NIH HHS - R01 MH059566
NCI NIH HHS - R01 CA087895 NIMH NIH HHS - R01 MH059565 NHLBI NIH HHS - U10 HL054495
NHLBI NIH HHS - U10 HL054496 NHLBI NIH HHS - U10 HL054497 PHS HHS - 44221
NHLBI NIH HHS - HL54472 NHLBI NIH HHS - HL54473 PHS HHS - HHSN268200625226C
NHLBI NIH HHS - HL54471 NHLBI NIH HHS - R01 HL087660 NIMH NIH HHS - R01 MH060870
NHLBI NIH HHS - U01HL072507 NIDA NIH HHS - R01 DA012844 PHS HHS - HHSN271200477451C
WHI NIH HHS - N01 WH042107 NHLBI NIH HHS - R01HL086694 NHLBI NIH HHS - N01-HC-55019
PHS HHS - 42107-26 PHS HHS - HHSN268200782096C NCI NIH HHS - R01 CA133996
NHLBI NIH HHS - N01-HC-55018 NHLBI NIH HHS - N01-HC-55015 PHS HHS - HHSN271200477471C
NHLBI NIH HHS - N01-HC-55016 NCRR NIH HHS - U54 RR020278 NHLBI NIH HHS - U10 HL054509
PHS HHS - 32115 NIDA NIH HHS - DA 02733 NIMH NIH HHS - R01 MH067257
NCI NIH HHS - R01 CA141716 NIMH NIH HHS - R01 MH060879 NHGRI NIH HHS - U01 HG004446
NIMH NIH HHS - U01 MH046276-08 NCI NIH HHS - R01CA55769 NCI NIH HHS - CA121197
NCRR NIH HHS - UL1 RR025005 NIMH NIH HHS - U01 MH046318-08 NHLBI NIH HHS - R01 HL086694
NIMH NIH HHS - U01 MH046289-08 WHI NIH HHS - N01 WH022110-024 NHLBI NIH HHS - N01-HC-55020
NIMH NIH HHS - R01 MH59588 NHLBI NIH HHS - N01-HC-55021 NCI NIH HHS - R01 CA121197
NHLBI NIH HHS - N01-HC-55022 NIMH NIH HHS - R01 MH59587 NIDA NIH HHS - R21 DA027331
NIMH NIH HHS - R01 MH81800 NIMH NIH HHS - R01 MH59586 NCI NIH HHS - R01 CA 52689
PHS HHS - 32100-2 NIMH NIH HHS - R01 MH059586 PHS HHS - 32122
NIMH NIH HHS - R01 MH059587 NIMH NIH HHS - R01 MH059588 NHLBI NIH HHS - R01 HL087641
NHLBI NIH HHS - HL54497 NHLBI NIH HHS - HL54496 NHLBI NIH HHS - HL54495
NCI NIH HHS - R01CA121197S2 NHGRI NIH HHS - U01 HG004436 NCI NIH HHS - R01CA141716
NHLBI NIH HHS - U10 HL054471 NHLBI NIH HHS - U10 HL054473 NHLBI NIH HHS - U10 HL054472
WHI NIH HHS - N01 WH032111 NCI NIH HHS - P50CA70907 NIEHS NIH HHS - R01 ES006717
NIMH NIH HHS - U01 MH079469 NIDA NIH HHS - DA 017441 PHS HHS - 32111-13
NIMH NIH HHS - R01 MH59571 NIDA NIH HHS - R01DA026911 NIDDK NIH HHS - P30 DK072488
NIDA NIH HHS - R03 DA023166 WHI NIH HHS - N01 WH044221 NCI NIH HHS - R01CA060691
NIMH NIH HHS - U01 MH79470 NIMH NIH HHS - U01 MH46276 WHI NIH HHS - N01 WH032108
WHI NIH HHS - N01 WH032105 NHGRI NIH HHS - U01 HG004422 NIMH NIH HHS - U01 MH079470
PHS HHS - 42129-32 NCI NIH HHS - R01 CA127219 NIMH NIH HHS - R01 MH59565
WHI NIH HHS - N01 WH032100 NHLBI NIH HHS - R01HL087641 NHLBI NIH HHS - HL68737
NIDA NIH HHS - R21 DA033827 NIMH NIH HHS - R01 MH59566 NIDA NIH HHS - R01 DA025888
WHI NIH HHS - N01 WH32115 NHLBI NIH HHS - N01 HC055019 NHLBI NIH HHS - U01 HL072507
NHLBI NIH HHS - N01 HC055018 NHLBI NIH HHS - N01 HC055015 NCI NIH HHS - PC35145
NIMH NIH HHS - U01 MH79469 NHLBI NIH HHS - N01 HC055016 PHS HHS - 32118-32119
NCI NIH HHS - N01PC35145 NCI NIH HHS - P01 CA089392 NCI NIH HHS - U19 CA148127
PHS HHS - 32105-6 NINDS NIH HHS - R01 NS45012 NIMH NIH HHS - U01 MH46289
NHLBI NIH HHS - U10 HL054515 NHLBI NIH HHS - U01 HL054457 NCI NIH HHS - R01CA87895

MeSH Terms:
Genetic Variation Odds Ratio Chromosomes, Human, Pair 15
Gene Frequency Genetics, Population Humans
African Americans Aged Phenotype
Asian Continental Ancestry Group Smoking Risk
Lung Neoplasms Aged, 80 and over Lung Diseases
European Continental Ancestry Group Adult Middle Aged
Adolescent African Continental Ancestry Group Male
Female

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Cotinine conundrum--a step forward but questions remain.
Authors: Spitz MR, Amos CI, Bierut LJ, Caporaso NE
Source: J Natl Cancer Inst, 2012 May 16;104(10), p. 720-2.
EPub date: 2012 Apr 25.
PMID: 22534783
Related Citations

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Neurophysiology of Nicotine Addiction.
Authors: Dani JA, Jenson D, Broussard JI, De Biasi M
Source: J Addict Res Ther, 2011 Apr 20;S1(1), p. null.
PMID: 22454789
Related Citations

Grant Numbers:
NCI NIH HHS - U19 CA148127 NIDA NIH HHS - R21 DA029157-01A1

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Comparison of pathway analysis approaches using lung cancer GWAS data sets.
Authors: Fehringer G, Liu G, Briollais L, Brennan P, Amos CI, Spitz MR, Bickeböller H, Wichmann HE, Risch A, Hung RJ
Source: PLoS One, 2012;7(2), p. e31816.
EPub date: 2012 Feb 21.
PMID: 22363742
Related Citations

Grant Numbers:
NCI NIH HHS - U19 CA148127-01

MeSH Terms:
Young Adult Software Odds Ratio
Humans Gene Regulatory Networks Aged
Receptors, Cholinergic False Positive Reactions Genome-Wide Association Study
Genotyping Techniques Aged, 80 and over Lung Neoplasms
Risk Factors Adult Middle Aged
Databases, Genetic Genetic Predisposition to Disease Signal Transduction
Female Male

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Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction.
Authors: VanderWeele TJ, Asomaning K, Tchetgen Tchetgen EJ, Han Y, Spitz MR, Shete S, Wu X, Gaborieau V, Wang Y, McLaughlin J, Hung RJ, Brennan P, Amos CI, Christiani DC, Lin X
Source: Am J Epidemiol, 2012 May 15;175(10), p. 1013-20.
EPub date: 2012 Feb 3.
PMID: 22306564
Related Citations

Grant Numbers:
NCI NIH HHS - CA092824 NIEHS NIH HHS - P30 ES000002 NCI NIH HHS - CA076404
NCI NIH HHS - R37 CA076404-16 PHS HHS - CPRIT RP10043 NIEHS NIH HHS - ES017876
NCI NIH HHS - CA074386 NCI NIH HHS - CA134294 NCI NIH HHS - U19 CA148127
NICHD NIH HHS - HD060696 NCI NIH HHS - P50CA70907-05 NCI NIH HHS - CA121197
NCI NIH HHS - R01CA133996

MeSH Terms:
Odds Ratio Polymorphism, Single Nucleotide Chromosomes, Human, Pair 15
Humans Linear Models Genotyping Techniques
Smoking Logistic Models Lung Neoplasms
Case-Control Studies Middle Aged Gene-Environment Interaction
Female Male

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Asthma and lung cancer risk: a systematic investigation by the International Lung Cancer Consortium.
Authors: Rosenberger A, Bickeböller H, McCormack V, Brenner DR, Duell EJ, Tjønneland A, Friis S, Muscat JE, Yang P, Wichmann HE, Heinrich J, Szeszenia-Dabrowska N, Lissowska J, Zaridze D, Rudnai P, Fabianova E, Janout V, Bencko V, Brennan P, Mates D, Schwartz AG, Cote ML, Zhang ZF, Morgenstern H, Oh SS, Field JK, Raji O, McLaughlin JR, Wiencke J, LeMarchand L, Neri M, Bonassi S, Andrew AS, Lan Q, Hu W, Orlow I, Park BJ, Boffetta P, Hung RJ
Source: Carcinogenesis, 2012 Mar;33(3), p. 587-97.
EPub date: 2011 Dec 22.
PMID: 22198214
Related Citations

Grant Numbers:
NCI NIH HHS - N01-PC35145 NCI NIH HHS - R01CA060691 NCI NIH HHS - CA80127
NCI NIH HHS - CA77118 NCI NIH HHS - P30CA22453 NIEHS NIH HHS - ES06717
NCI NIH HHS - CA-113710 NCI NIH HHS - R01CA87895 NCI NIH HHS - 1U19CA148127-01

MeSH Terms:
Small Cell Lung Carcinoma Lung Neoplasms Risk Factors
Humans Incidence Asthma
Carcinoma, Squamous Cell Male Female

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Genetic determinants for promoter hypermethylation in the lungs of smokers: a candidate gene-based study.
Authors: Leng S, Stidley CA, Liu Y, Edlund CK, Willink RP, Han Y, Landi MT, Thun M, Picchi MA, Bruse SE, Crowell RE, Van Den Berg D, Caporaso NE, Amos CI, Siegfried JM, Tesfaigzi Y, Gilliland FD, Belinsky SA
Source: Cancer Res, 2012 Feb 1;72(3), p. 707-15.
EPub date: 2011 Dec 2.
PMID: 22139380
Related Citations

Grant Numbers:
NCI NIH HHS - N01-CN-25518 NCI NIH HHS - R01 CA097356-08 NCI NIH HHS - N01-CN-25514
NCI NIH HHS - N01-CN-25515 NCI NIH HHS - N01-CN-25516 NCI NIH HHS - P50-CA090440
NCI NIH HHS - N01-CN-75022 NCI NIH HHS - N01-CN-25476 NCI NIH HHS - N01-CN-25511
NCI NIH HHS - N01-CN-25524 NCI NIH HHS - U19CA148127 NCI NIH HHS - N01-CN-25513
NCI NIH HHS - N01-CN-25522 NCI NIH HHS - N01-CN-25512 NCI NIH HHS - R01CA121197
NCI NIH HHS - N01-CN-25404

MeSH Terms:
Polymorphism, Single Nucleotide Tumor Suppressor Protein p53 Gene Frequency
Humans Aged DNA Ligases
Smoking Promoter Regions, Genetic Haplotypes
DNA Methylation Lung Neoplasms Genetic Predisposition to Disease
Male Apoptosis Regulatory Proteins Reverse Transcriptase Polymerase Chain Reaction
Membrane Proteins Gene Expression Profiling Epithelial Cells
Bronchi Cells, Cultured Lung
Risk Factors Cohort Studies Middle Aged
Female

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Testing Hardy-Weinberg proportions in a frequency-matched case-control genetic association study.
Authors: Wang J, Shete S
Source: PLoS One, 2011;6(11), p. e27642.
EPub date: 2011 Nov 14.
PMID: 22110703
Related Citations

Grant Numbers:
NCI NIH HHS - 1R01CA131324 NCI NIH HHS - U19CA148127 NCI NIH HHS - R01CA55769
NCI NIH HHS - R01CA121197

MeSH Terms:
Probability Polymorphism, Single Nucleotide Gene Frequency
Humans Genetic Markers Likelihood Functions
Genome-Wide Association Study Genotype Phenotype
Smoking Lung Neoplasms Case-Control Studies
Female Male

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A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk.
Authors: Wei C, Han Y, Spitz MR, Wu X, Chancoco H, Akiva P, Rechavi G, Brand H, Wun I, Frazier ML, Amos CI
Source: Cancer Epidemiol Biomarkers Prev, 2011 Dec;20(12), p. 2603-9.
EPub date: 2011 Oct 25.
PMID: 22028403
Related Citations

Grant Numbers:
NCI NIH HHS - U19 CA148127 NCI NIH HHS - R01 CA121197-04 NCI NIH HHS - R01 CA121197
NCI NIH HHS - CA55769 NCI NIH HHS - U19 CA148127-01 NCI NIH HHS - CA016672
NCI NIH HHS - R01 CA133996-03 NCI NIH HHS - 1P50 CA70907 NCI NIH HHS - CA127219
NCI NIH HHS - R01 CA127219-05

MeSH Terms:
United States Polymorphism, Single Nucleotide Chromosomes, Human, Pair 15
Sex Factors Humans DNA, Neoplasm
Genotype Lung Neoplasms Risk Factors
Case-Control Studies Chromosome Aberrations Middle Aged
Genetic Predisposition to Disease Female Male

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Meta-analysis combining new and existing data sets confirms that the TERT-CLPTM1L locus influences melanoma risk.
Authors: Law MH, Montgomery GW, Brown KM, Martin NG, Mann GJ, Hayward NK, MacGregor S, Q-MEGA and AMFS Investigators
Source: J Invest Dermatol, 2012 Feb;132(2), p. 485-7.
EPub date: 2011 Oct 13.
PMID: 21993562
Related Citations

Grant Numbers:
NCI NIH HHS - U19 CA148127 NCI NIH HHS - P01 CA087969-12 NCI NIH HHS - R01 CA122838-03
NCI NIH HHS - R01 CA088363-10 NCI NIH HHS - R01 CA133996-03 NCI NIH HHS - R01 CA083115-10
NCI NIH HHS - R01 CA049449-14 NCI NIH HHS - R01 CA100264-05 NCI NIH HHS - P01 CA055075-17

MeSH Terms:
Risk Polymorphism, Single Nucleotide Neoplasm Proteins
Telomerase Humans Skin Neoplasms
Membrane Proteins Melanoma Genome-Wide Association Study

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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Authors: Soler Artigas M, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, Zhai G, Zhao JH, Smith AV, Huffman JE, Albrecht E, Jackson CM, Evans DM, Cadby G, Fornage M, Manichaikul A, Lopez LM, Johnson T, Aldrich MC, Aspelund T, Barroso I, Campbell H, Cassano PA, Couper DJ, Eiriksdottir G, Franceschini N, Garcia M, Gieger C, Gislason GK, Grkovic I, Hammond CJ, Hancock DB, Harris TB, Ramasamy A, Heckbert SR, Heliövaara M, Homuth G, Hysi PG, James AL, Jankovic S, Joubert BR, Karrasch S, Klopp N, Koch B, Kritchevsky SB, Launer LJ, Liu Y, Loehr LR, Lohman K, Loos RJ, Lumley T, Al Balushi KA, Ang WQ, Barr RG, Beilby J, Blakey JD, Boban M, Boraska V, Brisman J, Britton JR, Brusselle GG, Cooper C, Curjuric I, Dahgam S, Deary IJ, Ebrahim S, Eijgelsheim M, Francks C, Gaysina D, Granell R, Gu X, Hankinson JL, Hardy R, Harris SE, Henderson J, Henry A, Hingorani AD, Hofman A, Holt PG, Hui J, Hunter ML, Imboden M, Jameson KA, Kerr SM, Kolcic I, Kronenberg F, Liu JZ, Marchini J, McKeever T, Morris AD, Olin AC, Porteous DJ, Postma DS, Rich SS, Ring SM, Rivadeneira F, Rochat T, Sayer AA, Sayers I, Sly PD, Smith GD, Sood A, Starr JM, Uitterlinden AG, Vonk JM, Wannamethee SG, Whincup PH, Wijmenga C, Williams OD, Wong A, Mangino M, Marciante KD, McArdle WL, Meibohm B, Morrison AC, North KE, Omenaas E, Palmer LJ, Pietiläinen KH, Pin I, Pola Sbreve Ek O, Pouta A, Psaty BM, Hartikainen AL, Rantanen T, Ripatti S, Rotter JI, Rudan I, Rudnicka AR, Schulz H, Shin SY, Spector TD, Surakka I, Vitart V, Völzke H, Wareham NJ, Warrington NM, Wichmann HE, Wild SH, Wilk JB, Wjst M, Wright AF, Zgaga L, Zemunik T, Pennell CE, Nyberg F, Kuh D, Holloway JW, Boezen HM, Lawlor DA, Morris RW, Probst-Hensch N, International Lung Cancer Consortium, GIANT consortium, Kaprio J, Wilson JF, Hayward C, Kähönen M, Heinrich J, Musk AW, Jarvis DL, Gläser S, Järvelin MR, Ch Stricker BH, Elliott P, O'Connor GT, Strachan DP, London SJ, Hall IP, Gudnason V, Tobin MD
Source: Nat Genet, 2011 Sep 25;43(11), p. 1082-90.
EPub date: 2011 Sep 25.
PMID: 21946350
Related Citations

Grant Numbers:
NIEHS NIH HHS - ES015794 NCI NIH HHS - CA127219 PHS HHS - 268201100012C
NHLBI NIH HHS - N01-HC-95095 NHLBI NIH HHS - HL088133 PHS HHS - 268200625226C
NIDDK NIH HHS - DK063491 PHS HHS - 268201100011C NHLBI NIH HHS - R01HL071051
Chief Scientist Office - CZD/16/6 NHLBI NIH HHS - HL075336 British Heart Foundation - FS05/125
NHLBI NIH HHS - N01-HC-85079 NHLBI NIH HHS - N01-HC-95159 PHS HHS - 268201100005C
Wellcome Trust - 076113/B/04/Z NCRR NIH HHS - UL1RR025005 NHLBI NIH HHS - 5R01HL087679-02
Medical Research Council - G0500539 NCRR NIH HHS - RR-024156 NHLBI NIH HHS - N01-HC-85081
NHLBI NIH HHS - N01-HC-95161 NHLBI NIH HHS - N01-HC-85082 NHLBI NIH HHS - N01-HC-95162
NHLBI NIH HHS - N01-HC-75150 NHLBI NIH HHS - N01-HC-85080 NHLBI NIH HHS - N01-HC-95160
NHLBI NIH HHS - N01-HC-85085 NCI NIH HHS - 1P50 CA70907 NHLBI NIH HHS - N01-HC-85086
NHLBI NIH HHS - N01-HC-85083 NHLBI NIH HHS - N01-HC-85084 NHLBI NIH HHS - N01-HC-45133
NHLBI NIH HHS - N01-HC-95169 NHLBI NIH HHS - R01HL59367 NHLBI NIH HHS - N01-HC-45134
NHLBI NIH HHS - N01-HC-95167 NHLBI NIH HHS - N01-HC-95168 NHLBI NIH HHS - N01-HC-95165
NHLBI NIH HHS - N01-HC-95166 NHLBI NIH HHS - N01-HC-95163 NHLBI NIH HHS - N01-HC-95164
NHLBI NIH HHS - R01 HL-074104 Medical Research Council - G0000934 NCRR NIH HHS - M01-RR00425
NHLBI NIH HHS - 1K23HL094531-01 Cancer Research UK - null Wellcome Trust - 068545/Z/02
NHLBI NIH HHS - N02-HL-6-4278 Medical Research Council - G9901462 PHS HHS - 268201100007C
NHLBI NIH HHS - R01-HL-084099 NIEHS NIH HHS - ZO1 ES49019 NHLBI NIH HHS - R01HL071259
PHS HHS - 268200782096C NHLBI NIH HHS - R01HL071258 Medical Research Council - G0501942
Biotechnology and Biological Sciences Research Council - BB/F019394/1 Wellcome Trust - 077016/Z/05/Z NIA NIH HHS - R01 AG032098
NHLBI NIH HHS - R01HL071251 NHLBI NIH HHS - R01HL071250 NCRR NIH HHS - 5M01 RR00997
NHLBI NIH HHS - R01HL071252 NHLBI NIH HHS - HL087652 PHS HHS - 268201100006C
NHGRI NIH HHS - U01-HG-004729 NCI NIH HHS - R01CA111703 NHLBI NIH HHS - R01HL086694
NHLBI NIH HHS - R01 HL-077612 British Heart Foundation - PG/97012 PHS HHS - 268201100009C
NHLBI NIH HHS - N01-HC-48050 NCI NIH HHS - CA55769 Medical Research Council - G0902313
NHLBI NIH HHS - HL080295 NHLBI NIH HHS - N01-HC-45204 Wellcome Trust - GR069224
Canadian Institutes of Health Research - MOP-82893 NHLBI NIH HHS - N01-HC-45205 NCI NIH HHS - R01 CA121197
NIA NIH HHS - AG-15928 PHS HHS - 268201100008C NIA NIH HHS - N01AG12100
Department of Health - null NIA NIH HHS - AG-023269 NHLBI NIH HHS - R01 HL-071022
NHLBI NIH HHS - N01-HC-48047 NIA NIH HHS - AG-20098 NHLBI NIH HHS - N01-HC-48048
NHLBI NIH HHS - N01-HC-35129 NHLBI NIH HHS - N01-HC-48049 NHLBI NIH HHS - N01 HC-15103
NHLBI NIH HHS - R01-HL084099 NHLBI NIH HHS - N01 HC-25195 NIMH NIH HHS - 1RL1MH083268-01
NIA NIH HHS - 1R01AG032098-01A1 NHGRI NIH HHS - U01-HG-004402 NIA NIH HHS - N01AG62101
NHLBI NIH HHS - R01HL071205 Medical Research Council - G0600705 PHS HHS - 268201100010C
Medical Research Council - G1000861 NHLBI NIH HHS - N01 HC-55222 NIMH NIH HHS - 5R01MH63706:02
NIA NIH HHS - N01AG62103 NIA NIH HHS - N01AG62106 NIA NIH HHS - AG035835
NHLBI NIH HHS - N01-HC-05187 NHLBI NIH HHS - R01HL087641 NHLBI NIH HHS - RC1 HL100543
British Heart Foundation - PG/06/154/22043 Wellcome Trust - 079895 Biotechnology and Biological Sciences Research Council - G20234
NCI NIH HHS - U19 CA148127 NIA NIH HHS - RC1 AG035835-01 NHLBI NIH HHS - HL105756
Medical Research Council - G0800582 NIA NIH HHS - AG-027058

MeSH Terms:
Respiratory Function Tests Humans European Continental Ancestry Group
Child Pulmonary Disease, Chronic Obstructive Genome-Wide Association Study

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Mechanistic insights into nicotine withdrawal.
Authors: Paolini M, De Biasi M
Source: Biochem Pharmacol, 2011 Oct 15;82(8), p. 996-1007.
EPub date: 2011 Jul 20.
PMID: 21782803
Related Citations

Grant Numbers:
NCI NIH HHS - U19 CA148127 NIDA NIH HHS - R21 DA029157-02 Howard Hughes Medical Institute - null
NCI NIH HHS - U19 CA148127-01 NIDA NIH HHS - R21 DA024385-02 NCI NIH HHS - R01 CA141716
NCI NIH HHS - U19 CA148127-02 NIDA NIH HHS - R01 DA017173-06A2 NIDA NIH HHS - DA024385
NIDA NIH HHS - R01 DA017173-07 NIDA NIH HHS - DA017173

MeSH Terms:
Animals Receptors, Nicotinic Substance Withdrawal Syndrome
Dopamine Nicotine Humans
Smoking Cessation Reinforcement (Psychology) Brain
Disease Models, Animal

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The landscape of recombination in African Americans.
Authors: Hinch AG, Tandon A, Patterson N, Song Y, Rohland N, Palmer CD, Chen GK, Wang K, Buxbaum SG, Akylbekova EL, Aldrich MC, Ambrosone CB, Amos C, Bandera EV, Berndt SI, Bernstein L, Blot WJ, Bock CH, Boerwinkle E, Cai Q, Caporaso N, Casey G, Cupples LA, Deming SL, Diver WR, Divers J, Fornage M, Gillanders EM, Glessner J, Harris CC, Hu JJ, Ingles SA, Isaacs W, John EM, Kao WH, Keating B, Kittles RA, Kolonel LN, Larkin E, Le Marchand L, McNeill LH, Millikan RC, Murphy A, Musani S, Neslund-Dudas C, Nyante S, Papanicolaou GJ, Press MF, Psaty BM, Reiner AP, Rich SS, Rodriguez-Gil JL, Rotter JI, Rybicki BA, Schwartz AG, Signorello LB, Spitz M, Strom SS, Thun MJ, Tucker MA, Wang Z, Wiencke JK, Witte JS, Wrensch M, Wu X, Yamamura Y, Zanetti KA, Zheng W, Ziegler RG, Zhu X, Redline S, Hirschhorn JN, Henderson BE, Taylor HA Jr, Price AL, Hakonarson H, Chanock SJ, Haiman CA, Wilson JG, Reich D, Myers SR
Source: Nature, 2011 Jul 20;476(7359), p. 170-5.
EPub date: 2011 Jul 20.
PMID: 21775986
Related Citations

Grant Numbers:
NCI NIH HHS - CA22453 NCI NIH HHS - CA68485 NCI NIH HHS - CA127219
NCI NIH HHS - CA100598 NCI NIH HHS - CA121197S2 NHGRI NIH HHS - U01 HG004168
NCI NIH HHS - CA54281 NHGRI NIH HHS - HG004726 NIGMS NIH HHS - GM091332
NCI NIH HHS - CA55769 NCI NIH HHS - CA100374 NCI NIH HHS - CA58223
NCI NIH HHS - CA68578 NCI NIH HHS - CA87895 NCI NIH HHS - CA121197
Wellcome Trust - null NCI NIH HHS - CA148085 NCI NIH HHS - CA141716
NCI NIH HHS - CA63464 NCI NIH HHS - CA148127 NICHD NIH HHS - HD33175
NHGRI NIH HHS - R01 HG006399-02 NCI NIH HHS - CA1116460 NIGMS NIH HHS - GM08016
NCI NIH HHS - CA88164 NHGRI NIH HHS - U01 HG004168-03 NCI NIH HHS - R01-CA73629
NCI NIH HHS - R01 CA052689-22 NHLBI NIH HHS - N01-HC-65226 NCI NIH HHS - CA1326792
NIEHS NIH HHS - ES06717 NCI NIH HHS - CA77305 NHLBI NIH HHS - HL084107
NCI NIH HHS - CA092447 NCI NIH HHS - CA060691 NCI NIH HHS - CA140388
NIEHS NIH HHS - ES007784 PHS HHS - HHSN268200960009C NIEHS NIH HHS - ES011126
NIEHS NIH HHS - ES10126 NHLBI NIH HHS - R01 HL084107-04 NCI NIH HHS - CA1116460S1

MeSH Terms:
Pedigree Probability Polymorphism, Single Nucleotide
Genome, Human Gene Frequency Genetics, Population
Humans Histone-Lysine N-Methyltransferase Africa, Western
African Americans Europe Chromosome Mapping
Evolution, Molecular Alleles Base Sequence
Haplotypes Amino Acid Motifs European Continental Ancestry Group
Molecular Sequence Data Crossing Over, Genetic Male
Female Genomics

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Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk.
Authors: Pande M, Spitz MR, Wu X, Gorlov IP, Chen WV, Amos CI
Source: Carcinogenesis, 2011 Oct;32(10), p. 1493-9.
EPub date: 2011 Jul 18.
PMID: 21771723
Related Citations

Grant Numbers:
NCI NIH HHS - U19 CA148127 NCI NIH HHS - R01 CA121197 NCI NIH HHS - CA55769
NCI NIH HHS - CA016672 NCI NIH HHS - CA127219 NCI NIH HHS - 1P50CA70907

MeSH Terms:
Polymorphism, Single Nucleotide Odds Ratio Telomerase
Humans Membrane Proteins Linkage Disequilibrium
Chromosomes, Human, Pair 5 Genome-Wide Association Study Genotype
Smoking Neoplasm Proteins Small Cell Lung Carcinoma
Haplotypes Lung Neoplasms Risk Factors
Case-Control Studies Middle Aged Genetic Predisposition to Disease
Adenocarcinoma Carcinoma, Squamous Cell Female
Male

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Principles for the post-GWAS functional characterization of cancer risk loci.
Authors: Freedman ML, Monteiro AN, Gayther SA, Coetzee GA, Risch A, Plass C, Casey G, De Biasi M, Carlson C, Duggan D, James M, Liu P, Tichelaar JW, Vikis HG, You M, Mills IG
Source: Nat Genet, 2011 Jun;43(6), p. 513-8.
PMID: 21614091
Related Citations

Grant Numbers:
NCI NIH HHS - U19 CA148127 NCI NIH HHS - U19 CA148537-01 NCI NIH HHS - U19 CA148107-01
NCI NIH HHS - U19 CA148127-01 NCI NIH HHS - 1U19CA148537-01 NCI NIH HHS - 1U19CA148107-01
NCI NIH HHS - 1U19CA148065-01 NCI NIH HHS - U19 CA148065-01 NCI NIH HHS - 1U19CA148112-01
NCI NIH HHS - U19 CA148112-01 NCI NIH HHS - 1U19CA148127-01

MeSH Terms:
Risk Regulatory Sequences, Nucleic Acid Genetic Variation
Catechols Polymorphism, Single Nucleotide Quantitative Trait Loci
Inositol Gene Expression Genetic Predisposition to Disease
Models, Biological Genome-Wide Association Study

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An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs.
Authors: Yu H, Zhao H, Wang LE, Han Y, Chen WV, Amos CI, Rafnar T, Sulem P, Stefansson K, Landi MT, Caporaso N, Albanes D, Thun M, McKay JD, Brennan P, Wang Y, Houlston RS, Spitz MR, Wei Q
Source: DNA Repair (Amst), 2011 Apr 3;10(4), p. 398-407.
EPub date: 2011 Feb 5.
PMID: 21296624
Related Citations

Grant Numbers:
NCI NIH HHS - U19 CA148127 NIEHS NIH HHS - R01 ES011740-10 NCI NIH HHS - CA 16672
NCI NIH HHS - R01 CA121197 NCI NIH HHS - CA131274 NCI NIH HHS - CA86390
NCI NIH HHS - CA55769 NCI NIH HHS - R01 CA131274-02 NIEHS NIH HHS - ES11740
NIEHS NIH HHS - R01 ES011740-07 NCI NIH HHS - R01 CA131274-04 NCI NIH HHS - CA121197

MeSH Terms:
Polymorphism, Single Nucleotide DNA Repair HeLa Cells
Humans DNA-Binding Proteins Aged
Texas Cell Line, Tumor Genome-Wide Association Study
Genotype Lung Neoplasms Adult
Case-Control Studies Genes, Reporter Middle Aged
Genetic Predisposition to Disease Male DNA Replication
Female

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Association of a novel functional promoter variant (rs2075533 C>T) in the apoptosis gene TNFSF8 with risk of lung cancer--a finding from Texas lung cancer genome-wide association study.
Authors: Wei S, Niu J, Zhao H, Liu Z, Wang LE, Han Y, Chen WV, Amos CI, Rafnar T, Sulem P, Stefansson K, Landi MT, Caporaso NE, Albanes D, Thun MJ, McKay JD, Brennan P, Wang Y, Houlston RS, Spitz MR, Wei Q
Source: Carcinogenesis, 2011 Apr;32(4), p. 507-15.
EPub date: 2011 Feb 2.
PMID: 21292647
Related Citations

Grant Numbers:
NCI NIH HHS - U19 CA148127 NCI NIH HHS - R01CA127219 NCI NIH HHS - R01 CA121197
NCI NIH HHS - P30 CA016672 NIEHS NIH HHS - R01ES011740 NCI NIH HHS - R01CA131274
NCI NIH HHS - R01CA055769 NCI NIH HHS - R01 CA133996 NCI NIH HHS - R01CA121197

MeSH Terms:
Antigens, CD30 Polymorphism, Single Nucleotide Apoptosis
CD30 Ligand Humans Aged
Texas Cell Line, Tumor Genome-Wide Association Study
Risk Promoter Regions, Genetic Lung Neoplasms
Adult Middle Aged Female
Male

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Admixture mapping of lung cancer in 1812 African-Americans.
Authors: Schwartz AG, Wenzlaff AS, Bock CH, Ruterbusch JJ, Chen W, Cote ML, Artis AS, Van Dyke AL, Land SJ, Harris CC, Pine SR, Spitz MR, Amos CI, Levin AM, McKeigue PM
Source: Carcinogenesis, 2011 Mar;32(3), p. 312-7.
EPub date: 2010 Nov 29.
PMID: 21115650
Related Citations

Grant Numbers:
NCI NIH HHS - R01-CA60691 NCI NIH HHS - R01-CA133996 NCI NIH HHS - N01-PC35145
NCI NIH HHS - R01-CA141716 NCI NIH HHS - R01-CA87895 NCI NIH HHS - P30CA22453
NCI NIH HHS - R01-CA55769 NCI NIH HHS - U19-CA148127 NCI NIH HHS - R01-CA127219
NCI NIH HHS - R01-CA121197

MeSH Terms:
Polymorphism, Single Nucleotide Humans African Americans
Aged DNA, Neoplasm Genome-Wide Association Study
Genotype Smoking Polymerase Chain Reaction
Small Cell Lung Carcinoma Lung Neoplasms Risk Factors
European Continental Ancestry Group Case-Control Studies Middle Aged
Genetic Predisposition to Disease Adenocarcinoma Carcinoma, Squamous Cell
Carcinoma, Non-Small-Cell Lung Male Female

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Evaluating a New Risk Marker's Predictive Contribution in Survival Models.
Authors: Liu M, Kapadia AS, Etzel CJ
Source: J Stat Theory Pract, 2010 Dec 1;4(4), p. 845-855.
PMID: 22984361
Related Citations

Grant Numbers:
NCI NIH HHS - U19 CA148127 NCI NIH HHS - U19 CA148127-01 NCI NIH HHS - R01 CA131327-01A1
NCI NIH HHS - R01 CA131327-02

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Ordered subset analysis identifies loci influencing lung cancer risk on chromosomes 6q and 12q.
Authors: Fang S, Pinney SM, Bailey-Wilson JE, de Andrade MA, Li Y, Kupert E, You M, Schwartz AG, Yang P, Anderson MW, Amos CI
Source: Cancer Epidemiol Biomarkers Prev, 2010 Dec;19(12), p. 3157-66.
EPub date: 2010 Oct 28.
PMID: 21030603
Related Citations

Grant Numbers:
NCI NIH HHS - P50CA70907 NCI NIH HHS - R01 CA121197-04 NCI NIH HHS - P30CA016772
NIEHS NIH HHS - P30ES007784 NIEHS NIH HHS - P30ES007789 NCI NIH HHS - UO1CA076293
NCI NIH HHS - N01PC35145 NCI NIH HHS - R01CA060691 NCI NIH HHS - U01 CA076293-10
NCI NIH HHS - U19 CA148127-01 NCI NIH HHS - R01 CA133996-03 NIEHS NIH HHS - P30ES06096
NCI NIH HHS - R01CA87895 NCI NIH HHS - R01CA133996

MeSH Terms:
Lung Neoplasms Lod Score Risk Factors
Humans Middle Aged Genetic Predisposition to Disease
Chromosomes, Human, Pair 6 Male Female
Chromosomes, Human, Pair 12 Genome-Wide Association Study

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Interactions between cigarette smoking and selected polymorphisms in xenobiotic metabolizing enzymes in risk for colorectal cancer: A case-only analysis.
Authors: Pande M, Amos CI, Eng C, Frazier ML
Source: Mol Carcinog, 2010 Nov;49(11), p. 974-80.
PMID: 20886582
Related Citations

Grant Numbers:
NCI NIH HHS - U19 CA148127 NCI NIH HHS - R01 CA070759-08 NCI NIH HHS - R01 CA133996-03
NCI NIH HHS - R01 CA141716 NCI NIH HHS - R25 CA057730-09 NCI NIH HHS - CA133996
NCI NIH HHS - CA070759 NCI NIH HHS - CA16672 NCI NIH HHS - CA57730

MeSH Terms:
United States Polymorphism, Single Nucleotide Humans
Cytochrome P-450 CYP1A1 Prognosis Genotype
Smoking Polymerase Chain Reaction Risk Factors
Epoxide Hydrolases Case-Control Studies Middle Aged
Colorectal Neoplasms Female Male

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Last Updated: August 24, 2012
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