Grant Details
Grant Number: |
7U19CA148127-03 Interpret this number |
Primary Investigator: |
Amos, Christopher |
Organization: |
Dartmouth College |
Project Title: |
Transdisciplinary Research in Cancer of the Lung (TRICL) |
Fiscal Year: |
2012 |
Abstract
Lung cancer is the leading cause of cancer-related mortality in the U.S. and the world. The genetic factors that commonly influence lung cancer susceptibility have not yet been investigated thoroughly, but eight genome-wide association studies have been performed. In area 1 of our response, we propose to integrate data from these eight studies that comprise over 13,000 lung cancer cases and 25,000 controls to increase
power to detect genetic factors influencing all types of lung cancer and to allow us to analyze specific subsets, such as cases with early onset, specific histological sets, gender-defined groups and never smokers and the extended sample size will allow us to study gene-environment interactions. Existing genome-wide association studies have not analyzed data from nonCaucasian ethnic backgrounds and we therefore propose characterizing and fine mapping genetic factoid In 1500 African-American and 1500 Asian case-control pairs along with an additional 3000 Caucasian case-control pairs. We will then replicate our findings in a broader collection of an additional 12,000 case-control pairs. In area 2, we will evaluate genes in specific loci including nicotinic acetycholine receptor subunits CHRNA5 and CHRNA3 for the effiects that
identified SNPs from area 1 have upon these genes functions. We will also study several other loci that have been identified through existing GWAS as strongly associated with lung cancer risk, including PSMA4, hTERT, CLPT1 ML, BAT3, and hMSHS. For each of these genes, we will study modulation of these genes
using cellular models relevant to their known functions. In area 3, we propose epidemiological characterization of genetic and environmental risk factors for lung cancer. We will characterize mechanisms by which variation in the loci identified in area 1 influence risk, in conjunction with smoking and other exposures. We will also evaluate the calibration of existing risk prediction models for lung cancer and then
develop new models based upon genetic and environmental data from this initiative. The overarching goal of our proposal is the identification of individuals at high risk for lung cancer development for whom screening and early detection would be most beneficial in reducing the burden of lung cancer.
Publications
Genomic sequencing in cancer.
Authors: Tuna M, Amos CI
Source: Cancer Lett, 2012 Nov 23;null, p. null.
EPub date: 2012 Nov 23.
PMID: 23178448
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Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer.
Authors: Wang LE, Gorlova OY, Ying J, Qiao Y, Weng SF, Lee AT, Gregersen PK, Spitz MR, Amos CI, Wei Q
Source: Cancer Res, 2013 Jan 1;73(1), p. 256-64.
EPub date: 2012 Oct 29.
PMID: 23108145
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Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.
Authors: Jin G, Ma H, Wu C, Dai J, Zhang R, Shi Y, Lu J, Miao X, Wang M, Zhou Y, Chen J, Li H, Pan S, Chu M, Lu F, Yu D, Jiang Y, Dong J, Hu L, Chen Y, Xu L, Shu Y, Pan S, Tan W, Zhou B, Lu D, Wu T, Zhang Z, Chen F, Wang X, Hu Z, Lin D, Shen H
Source: Am J Hum Genet, 2012 Nov 2;91(5), p. 928-34.
EPub date: 2012 Oct 25.
PMID: 23103227
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Genetic association analysis of complex diseases incorporating intermediate phenotype information.
Authors: Li Y, Huang J, Amos CI
Source: PLoS One, 2012;7(10), p. e46612.
EPub date: 2012 Oct 19.
PMID: 23094028
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Method for evaluating multiple mediators: mediating effects of smoking and COPD on the association between the CHRNA5-A3 variant and lung cancer risk.
Authors: Wang J, Spitz MR, Amos CI, Wu X, Wetter DW, Cinciripini PM, Shete S
Source: PLoS One, 2012;7(10), p. e47705.
EPub date: 2012 Oct 15.
PMID: 23077662
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Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4.
Authors: Scherf DB, Sarkisyan N, Jacobsson H, Claus R, Bermejo JL, Peil B, Gu L, Muley T, Meister M, Dienemann H, Plass C, Risch A
Source: Oncogene, 2012 Sep 3;null, p. null.
EPub date: 2012 Sep 3.
PMID: 22945651
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Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.
Authors: Timofeeva MN, Hung RJ, Rafnar T, Christiani DC, Field JK, Bickeböller H, Risch A, McKay JD, Wang Y, Dai J, Gaborieau V, McLaughlin J, Brenner D, Narod SA, Caporaso NE, Albanes D, Thun M, Eisen T, Wichmann HE, Rosenberger A, Han Y, Chen W, Zhu D, Spitz M, Wu X, Pande M, Zhao Y, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Krokan HE, Gabrielsen ME, Skorpen F, Vatten L, Njølstad I, Chen C, Goodman G, Lathrop M, Benhamou S, Vooder T, Välk K, Nelis M, Metspalu A, Raji O, Chen Y, Gosney J, Liloglou T, Muley T, Dienemann H, Thorleifsson G, Shen H, Stefansson K, Brennan P, Amos CI, Houlston R, Landi MT, Transdisciplinary Research in Cancer of the Lung (TRICL) Research Team
Source: Hum Mol Genet, 2012 Nov 15;21(22), p. 4980-95.
EPub date: 2012 Aug 16.
PMID: 22899653
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Natural and orthogonal interaction framework for modeling gene-environment interactions with application to lung cancer.
Authors: Ma J, Xiao F, Xiong M, Andrew AS, Brenner H, Duell EJ, Haugen A, Hoggart C, Hung RJ, Lazarus P, Liu C, Matsuo K, Mayordomo JI, Schwartz AG, Staratschek-Jox A, Wichmann E, Yang P, Amos CI
Source: Hum Hered, 2012;73(4), p. 185-94.
EPub date: 2012 Aug 9.
PMID: 22889990
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Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.
Authors: Hu L, Wu C, Zhao X, Heist R, Su L, Zhao Y, Han B, Cao S, Chu M, Dai J, Dong J, Shu Y, Xu L, Chen Y, Wang Y, Lu F, Jiang Y, Yu D, Chen H, Tan W, Ma H, Chen J, Jin G, Wu T, Lu D, Christiani DC, Lin D, Hu Z, Shen H
Source: Clin Cancer Res, 2012 Oct 1;18(19), p. 5507-14.
EPub date: 2012 Aug 7.
PMID: 22872573
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Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.
Authors: Hartz SM, Short SE, Saccone NL, Culverhouse R, Chen L, Schwantes-An TH, Coon H, Han Y, Stephens SH, Sun J, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Geller F, Gubjartsson D, Hansel NN, Jiang C, Keskitalo-Vuokko K, Liu Z, Lyytikäinen LP, Michel M, Rawal R, Rosenberger A, Scheet P, Shaffer JR, Teumer A, Thompson JR, Vink JM, Vogelzangs N, Wenzlaff AS, Wheeler W, Xiao X, Yang BZ, Aggen SH, Balmforth AJ, Baumeister SE, Beaty T, Bennett S, Bergen AW, Boyd HA, Broms U, Campbell H, Chatterjee N, Chen J, Cheng YC, Cichon S, Couper D, Cucca F, Dick DM, Foroud T, Furberg H, Giegling I, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Hayward C, Heikkilä K, Hewitt JK, Hottenga JJ, Jensen MK, Jousilahti P, Kaakinen M, Kittner SJ, Konte B, Korhonen T, Landi MT, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Muley T, Murray T, Nauck M, North K, Pergadia M, Polasek O, Ramos EM, Ripatti S, Risch A, Ruczinski I, Rudan I, Salomaa V, Schlessinger D, Styrkársdóttir U, Terracciano A, Uda M, Willemsen G, Wu X, Abecasis G, Barnes K, Bickeböller H, Boerwinkle E, Boomsma DI, Caporaso N, Duan J, Edenberg HJ, Francks C, Gejman PV, Gelernter J, Grabe HJ, Hops H, Jarvelin MR, Viikari J, Kähönen M, Kendler KS, Lehtimäki T, Levinson DF, Marazita ML, Marchini J, Melbye M, Mitchell BD, Murray JC, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Sanders AR, Schwartz AG, Shete S, Shi J, Spitz M, Stefansson K, Swan GE, Thorgeirsson T, Völzke H, Wei Q, Wichmann HE, Amos CI, Breslau N, Cannon DS, Ehringer M, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Stitzel JA, Weiss RB, Kraft P, Bierut LJ
Source: Arch Gen Psychiatry, 2012 Aug;69(8), p. 854-60.
PMID: 22868939
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The influence of race and ethnicity on the biology of cancer.
Authors: Henderson BE, Lee NH, Seewaldt V, Shen H
Source: Nat Rev Cancer, 2012 Sep;12(9), p. 648-53.
EPub date: 2012 Aug 2.
PMID: 22854838
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Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population.
Authors: Dong J, Hu Z, Wu C, Guo H, Zhou B, Lv J, Lu D, Chen K, Shi Y, Chu M, Wang C, Zhang R, Dai J, Jiang Y, Cao S, Qin Z, Yu D, Ma H, Jin G, Gong J, Sun C, Zhao X, Yin Z, Yang L, Li Z, Deng Q, Wang J, Wu W, Zheng H, Zhou G, Chen H, Guan P, Peng Z, Chen Y, Shu Y, Xu L, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y, Zhang H, Yan Y, Amos CI, Chen F, Tan W, Jin L, Wu T, Lin D, Shen H
Source: Nat Genet, 2012 Jul 15;44(8), p. 895-9.
EPub date: 2012 Jul 15.
PMID: 22797725
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Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus.
Authors: James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J, You M
Source: PLoS One, 2012;7(6), p. e36116.
EPub date: 2012 Jun 4.
PMID: 22675468
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Genome-wide gene-environment interaction analysis for asbestos exposure in lung cancer susceptibility.
Authors: Wei S, Wang LE, McHugh MK, Han Y, Xiong M, Amos CI, Spitz MR, Wei QW
Source: Carcinogenesis, 2012 Aug;33(8), p. 1531-7.
EPub date: 2012 May 27.
PMID: 22637743
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Variants in inflammation genes are implicated in risk of lung cancer in never smokers exposed to second-hand smoke.
Authors: Spitz MR, Gorlov IP, Amos CI, Dong Q, Chen W, Etzel CJ, Gorlova OY, Chang DW, Pu X, Zhang D, Wang L, Cunningham JM, Yang P, Wu X
Source: Cancer Discov, 2011 Oct;1(5), p. 420-9.
EPub date: 2011 Aug 25.
PMID: 22586632
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Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma.
Authors: Shi J, Chatterjee N, Rotunno M, Wang Y, Pesatori AC, Consonni D, Li P, Wheeler W, Broderick P, Henrion M, Eisen T, Wang Z, Chen W, Dong Q, Albanes D, Thun M, Spitz MR, Bertazzi PA, Caporaso NE, Chanock SJ, Amos CI, Houlston RS, Landi MT
Source: Cancer Discov, 2012 Feb;2(2), p. 131-9.
EPub date: 2011 Dec 7.
PMID: 22585858
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Multistage analysis of variants in the inflammation pathway and lung cancer risk in smokers.
Authors: Spitz MR, Gorlov IP, Dong Q, Wu X, Chen W, Chang DW, Etzel CJ, Caporaso NE, Zhao Y, Christiani DC, Brennan P, Albanes D, Shi J, Thun M, Landi MT, Amos CI
Source: Cancer Epidemiol Biomarkers Prev, 2012 Jul;21(7), p. 1213-21.
EPub date: 2012 May 9.
PMID: 22573796
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Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25.
Authors: Chen LS, Saccone NL, Culverhouse RC, Bracci PM, Chen CH, Dueker N, Han Y, Huang H, Jin G, Kohno T, Ma JZ, Przybeck TR, Sanders AR, Smith JA, Sung YJ, Wenzlaff AS, Wu C, Yoon D, Chen YT, Cheng YC, Cho YS, David SP, Duan J, Eaton CB, Furberg H, Goate AM, Gu D, Hansen HM, Hartz S, Hu Z, Kim YJ, Kittner SJ, Levinson DF, Mosley TH, Payne TJ, Rao DC, Rice JP, Rice TK, Schwantes-An TH, Shete SS, Shi J, Spitz MR, Sun YV, Tsai FJ, Wang JC, Wrensch MR, Xian H, Gejman PV, He J, Hunt SC, Kardia SL, Li MD, Lin D, Mitchell BD, Park T, Schwartz AG, Shen H, Wiencke JK, Wu JY, Yokota J, Amos CI, Bierut LJ
Source: Genet Epidemiol, 2012 May;36(4), p. 340-51.
PMID: 22539395
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Cotinine conundrum--a step forward but questions remain.
Authors: Spitz MR, Amos CI, Bierut LJ, Caporaso NE
Source: J Natl Cancer Inst, 2012 May 16;104(10), p. 720-2.
EPub date: 2012 Apr 25.
PMID: 22534783
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Neurophysiology of Nicotine Addiction.
Authors: Dani JA, Jenson D, Broussard JI, De Biasi M
Source: J Addict Res Ther, 2011 Apr 20;S1(1), p. null.
PMID: 22454789
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Comparison of pathway analysis approaches using lung cancer GWAS data sets.
Authors: Fehringer G, Liu G, Briollais L, Brennan P, Amos CI, Spitz MR, Bickeböller H, Wichmann HE, Risch A, Hung RJ
Source: PLoS One, 2012;7(2), p. e31816.
EPub date: 2012 Feb 21.
PMID: 22363742
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Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction.
Authors: VanderWeele TJ, Asomaning K, Tchetgen Tchetgen EJ, Han Y, Spitz MR, Shete S, Wu X, Gaborieau V, Wang Y, McLaughlin J, Hung RJ, Brennan P, Amos CI, Christiani DC, Lin X
Source: Am J Epidemiol, 2012 May 15;175(10), p. 1013-20.
EPub date: 2012 Feb 3.
PMID: 22306564
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Asthma and lung cancer risk: a systematic investigation by the International Lung Cancer Consortium.
Authors: Rosenberger A, Bickeböller H, McCormack V, Brenner DR, Duell EJ, Tjønneland A, Friis S, Muscat JE, Yang P, Wichmann HE, Heinrich J, Szeszenia-Dabrowska N, Lissowska J, Zaridze D, Rudnai P, Fabianova E, Janout V, Bencko V, Brennan P, Mates D, Schwartz AG, Cote ML, Zhang ZF, Morgenstern H, Oh SS, Field JK, Raji O, McLaughlin JR, Wiencke J, LeMarchand L, Neri M, Bonassi S, Andrew AS, Lan Q, Hu W, Orlow I, Park BJ, Boffetta P, Hung RJ
Source: Carcinogenesis, 2012 Mar;33(3), p. 587-97.
EPub date: 2011 Dec 22.
PMID: 22198214
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Genetic determinants for promoter hypermethylation in the lungs of smokers: a candidate gene-based study.
Authors: Leng S, Stidley CA, Liu Y, Edlund CK, Willink RP, Han Y, Landi MT, Thun M, Picchi MA, Bruse SE, Crowell RE, Van Den Berg D, Caporaso NE, Amos CI, Siegfried JM, Tesfaigzi Y, Gilliland FD, Belinsky SA
Source: Cancer Res, 2012 Feb 1;72(3), p. 707-15.
EPub date: 2011 Dec 2.
PMID: 22139380
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Testing Hardy-Weinberg proportions in a frequency-matched case-control genetic association study.
Authors: Wang J, Shete S
Source: PLoS One, 2011;6(11), p. e27642.
EPub date: 2011 Nov 14.
PMID: 22110703
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A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk.
Authors: Wei C, Han Y, Spitz MR, Wu X, Chancoco H, Akiva P, Rechavi G, Brand H, Wun I, Frazier ML, Amos CI
Source: Cancer Epidemiol Biomarkers Prev, 2011 Dec;20(12), p. 2603-9.
EPub date: 2011 Oct 25.
PMID: 22028403
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Meta-analysis combining new and existing data sets confirms that the TERT-CLPTM1L locus influences melanoma risk.
Authors: Law MH, Montgomery GW, Brown KM, Martin NG, Mann GJ, Hayward NK, MacGregor S, Q-MEGA and AMFS Investigators
Source: J Invest Dermatol, 2012 Feb;132(2), p. 485-7.
EPub date: 2011 Oct 13.
PMID: 21993562
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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Authors: Soler Artigas M, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, Zhai G, Zhao JH, Smith AV, Huffman JE, Albrecht E, Jackson CM, Evans DM, Cadby G, Fornage M, Manichaikul A, Lopez LM, Johnson T, Aldrich MC, Aspelund T, Barroso I, Campbell H, Cassano PA, Couper DJ, Eiriksdottir G, Franceschini N, Garcia M, Gieger C, Gislason GK, Grkovic I, Hammond CJ, Hancock DB, Harris TB, Ramasamy A, Heckbert SR, Heliövaara M, Homuth G, Hysi PG, James AL, Jankovic S, Joubert BR, Karrasch S, Klopp N, Koch B, Kritchevsky SB, Launer LJ, Liu Y, Loehr LR, Lohman K, Loos RJ, Lumley T, Al Balushi KA, Ang WQ, Barr RG, Beilby J, Blakey JD, Boban M, Boraska V, Brisman J, Britton JR, Brusselle GG, Cooper C, Curjuric I, Dahgam S, Deary IJ, Ebrahim S, Eijgelsheim M, Francks C, Gaysina D, Granell R, Gu X, Hankinson JL, Hardy R, Harris SE, Henderson J, Henry A, Hingorani AD, Hofman A, Holt PG, Hui J, Hunter ML, Imboden M, Jameson KA, Kerr SM, Kolcic I, Kronenberg F, Liu JZ, Marchini J, McKeever T, Morris AD, Olin AC, Porteous DJ, Postma DS, Rich SS, Ring SM, Rivadeneira F, Rochat T, Sayer AA, Sayers I, Sly PD, Smith GD, Sood A, Starr JM, Uitterlinden AG, Vonk JM, Wannamethee SG, Whincup PH, Wijmenga C, Williams OD, Wong A, Mangino M, Marciante KD, McArdle WL, Meibohm B, Morrison AC, North KE, Omenaas E, Palmer LJ, Pietiläinen KH, Pin I, Pola Sbreve Ek O, Pouta A, Psaty BM, Hartikainen AL, Rantanen T, Ripatti S, Rotter JI, Rudan I, Rudnicka AR, Schulz H, Shin SY, Spector TD, Surakka I, Vitart V, Völzke H, Wareham NJ, Warrington NM, Wichmann HE, Wild SH, Wilk JB, Wjst M, Wright AF, Zgaga L, Zemunik T, Pennell CE, Nyberg F, Kuh D, Holloway JW, Boezen HM, Lawlor DA, Morris RW, Probst-Hensch N, International Lung Cancer Consortium, GIANT consortium, Kaprio J, Wilson JF, Hayward C, Kähönen M, Heinrich J, Musk AW, Jarvis DL, Gläser S, Järvelin MR, Ch Stricker BH, Elliott P, O'Connor GT, Strachan DP, London SJ, Hall IP, Gudnason V, Tobin MD
Source: Nat Genet, 2011 Sep 25;43(11), p. 1082-90.
EPub date: 2011 Sep 25.
PMID: 21946350
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Mechanistic insights into nicotine withdrawal.
Authors: Paolini M, De Biasi M
Source: Biochem Pharmacol, 2011 Oct 15;82(8), p. 996-1007.
EPub date: 2011 Jul 20.
PMID: 21782803
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The landscape of recombination in African Americans.
Authors: Hinch AG, Tandon A, Patterson N, Song Y, Rohland N, Palmer CD, Chen GK, Wang K, Buxbaum SG, Akylbekova EL, Aldrich MC, Ambrosone CB, Amos C, Bandera EV, Berndt SI, Bernstein L, Blot WJ, Bock CH, Boerwinkle E, Cai Q, Caporaso N, Casey G, Cupples LA, Deming SL, Diver WR, Divers J, Fornage M, Gillanders EM, Glessner J, Harris CC, Hu JJ, Ingles SA, Isaacs W, John EM, Kao WH, Keating B, Kittles RA, Kolonel LN, Larkin E, Le Marchand L, McNeill LH, Millikan RC, Murphy A, Musani S, Neslund-Dudas C, Nyante S, Papanicolaou GJ, Press MF, Psaty BM, Reiner AP, Rich SS, Rodriguez-Gil JL, Rotter JI, Rybicki BA, Schwartz AG, Signorello LB, Spitz M, Strom SS, Thun MJ, Tucker MA, Wang Z, Wiencke JK, Witte JS, Wrensch M, Wu X, Yamamura Y, Zanetti KA, Zheng W, Ziegler RG, Zhu X, Redline S, Hirschhorn JN, Henderson BE, Taylor HA Jr, Price AL, Hakonarson H, Chanock SJ, Haiman CA, Wilson JG, Reich D, Myers SR
Source: Nature, 2011 Jul 20;476(7359), p. 170-5.
EPub date: 2011 Jul 20.
PMID: 21775986
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Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk.
Authors: Pande M, Spitz MR, Wu X, Gorlov IP, Chen WV, Amos CI
Source: Carcinogenesis, 2011 Oct;32(10), p. 1493-9.
EPub date: 2011 Jul 18.
PMID: 21771723
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Principles for the post-GWAS functional characterization of cancer risk loci.
Authors: Freedman ML, Monteiro AN, Gayther SA, Coetzee GA, Risch A, Plass C, Casey G, De Biasi M, Carlson C, Duggan D, James M, Liu P, Tichelaar JW, Vikis HG, You M, Mills IG
Source: Nat Genet, 2011 Jun;43(6), p. 513-8.
PMID: 21614091
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An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs.
Authors: Yu H, Zhao H, Wang LE, Han Y, Chen WV, Amos CI, Rafnar T, Sulem P, Stefansson K, Landi MT, Caporaso N, Albanes D, Thun M, McKay JD, Brennan P, Wang Y, Houlston RS, Spitz MR, Wei Q
Source: DNA Repair (Amst), 2011 Apr 3;10(4), p. 398-407.
EPub date: 2011 Feb 5.
PMID: 21296624
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Association of a novel functional promoter variant (rs2075533 C>T) in the apoptosis gene TNFSF8 with risk of lung cancer--a finding from Texas lung cancer genome-wide association study.
Authors: Wei S, Niu J, Zhao H, Liu Z, Wang LE, Han Y, Chen WV, Amos CI, Rafnar T, Sulem P, Stefansson K, Landi MT, Caporaso NE, Albanes D, Thun MJ, McKay JD, Brennan P, Wang Y, Houlston RS, Spitz MR, Wei Q
Source: Carcinogenesis, 2011 Apr;32(4), p. 507-15.
EPub date: 2011 Feb 2.
PMID: 21292647
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Admixture mapping of lung cancer in 1812 African-Americans.
Authors: Schwartz AG, Wenzlaff AS, Bock CH, Ruterbusch JJ, Chen W, Cote ML, Artis AS, Van Dyke AL, Land SJ, Harris CC, Pine SR, Spitz MR, Amos CI, Levin AM, McKeigue PM
Source: Carcinogenesis, 2011 Mar;32(3), p. 312-7.
EPub date: 2010 Nov 29.
PMID: 21115650
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Evaluating a New Risk Marker's Predictive Contribution in Survival Models.
Authors: Liu M, Kapadia AS, Etzel CJ
Source: J Stat Theory Pract, 2010 Dec 1;4(4), p. 845-855.
PMID: 22984361
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Ordered subset analysis identifies loci influencing lung cancer risk on chromosomes 6q and 12q.
Authors: Fang S, Pinney SM, Bailey-Wilson JE, de Andrade MA, Li Y, Kupert E, You M, Schwartz AG, Yang P, Anderson MW, Amos CI
Source: Cancer Epidemiol Biomarkers Prev, 2010 Dec;19(12), p. 3157-66.
EPub date: 2010 Oct 28.
PMID: 21030603
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Interactions between cigarette smoking and selected polymorphisms in xenobiotic metabolizing enzymes in risk for colorectal cancer: A case-only analysis.
Authors: Pande M, Amos CI, Eng C, Frazier ML
Source: Mol Carcinog, 2010 Nov;49(11), p. 974-80.
PMID: 20886582
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