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Question ID: WS-55
Submitted by: Kenneth Brasel
February 10, 2011
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Question ID: WS-55
Submitted by: Kenneth Brasel
February 10, 2011
Do liver NKT cells negatively regulate anti-tumor CD8 T cells? Work by Nick Crispe's lab has shown that NKT cells in the liver selectively kill activated CD1d expressing T cells(J Immunol.,2004,172:5222). In addition, several studies using NKT cell deficient mice (CD1d KO) clear tumors faster than WT hosts. NK T cells may naturally keep number of activated CD8 T cells low to suppress autoimmunity, but as consiquence it will also limit the numbers of T cells that could regulate tumor outgrowth. In addition, this mechanism may explain why large numbers of infused CD8 cells, expanded in vitro, do not persist in vivo.
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