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Question ID: WS-98
Submitted by: Eleanor Rogan
June 28, 2011
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Question ID: WS-98
Submitted by: Eleanor Rogan
June 28, 2011
Can studying cancer etiology guide us to effective cancer prevention? BACKGROUND: The metabolism of estrogens can produce catechol estrogen quinones that react with DNA to form estrogen-DNA adducts and give rise to the series of events that lead to the development of cancer. FEASIBILITY: Determination of estrogen-DNA adducts at the cellular and human levels can provide important information concerning the presumed first step in cancer development. By knowing this step, one can investigate strategies to prevent it. IMPLICATIONS FOR PUBLIC HEALTH: By preventing the first step in the development of cancer, one could develop widely-applicable approaches to reducing the incidence of cancer.
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