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Question ID: WS-112
Submitted by: Sidharth Kerkar
August 9, 2011

What is the role of inflammation in cancer (friend or foe)? Despite the plethora of data showing that inflammation drives carcinogenesis, acute inflammatory mediators such as IL-12, IFN-gamma, TNF-alpha, and IL-17 have been shown to enhance anti-tumor immunity. The intricacies and mechanisms responsible for this perplexing duality remain largely unexplored. The answers to this question may play a major role in designing the next generation of cancer therapeutics. Sid Kerkar

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