Lothar Hennighausen, Ph.D.


LGP
LABORATORY GENETICS & PHYSIOLOGY
NIDDK, National Institutes of Health
Building 8 , Room 101
8 Center Dr.
Bethesda, MD 20814
Tel: 301-496-2716
Fax: 301-480-7312
Email: lotharh@helix.nih.gov

Lothar Hennighausen, Ph.D.

Research Website:


Education / Previous Training and Experience:
B.S., Marburg (Germany), 1977
M.S., Cologne, Germany, 1979
Ph.D., Cologne, Germany, 1982


Research Statement:

Identify and explore genetic switches and biochemical pathways that control organogenesis, with an emphasis on the mammary gland. Investigate pathways that control oncogenic transformation in the mammary gland and prostate. We have identified genes, which are critical for normal mammary development, and their role is being studied through their deletion from the mouse genome by homologous recombination and their deregulated expression in mammary tissue of transgenic mice. We have established that the prolactin - Jak2/Stat5 pathway is critical for the specification, proliferation and differentiation of mammary epithelium. Current projects include the analysis of the prolactin/Jak2/Stat5 and b-catenin signaling pathway in cell specification and cell fate determination, the roles of inhibinbB and C/EBPb in mammary development and function, and the role of Bcl-2 family members on mammary gland remodeling during involution. Experimental emphasis is on the establishment of genetic systems that permit the cell-specific and temporal inactivation and reactivation of genes in the mouse. In addition, LGP has established public resource for the field of mammary gland biology, the 'Biology of the Mammary Gland' web site, and the NIH Histobank, a repository for high-resolution images from mouse models and human disease.



Selected Publications:

1. Lee JY, Ristow M, Lin X, White MF, Magnuson MA, Hennighausen L RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem (281): 2649-53, 2006. [Full Text/Abstract]

2. Yao Z, Cui Y, Watford WT, Bream JH, Yamaoka K, Hissong BD, Li D, Durum SK, Jiang Q, Bhandoola A, Hennighausen L, O''Shea JJ Stat5a/b are essential for normal lymphoid development and differentiation. Proc Natl Acad Sci U S A (103): 1000-5, 2006. [Full Text/Abstract]

3. Buono KD, Robinson GW, Martin C, Shi S, Stanley P, Tanigaki K, Honjo T, Hennighausen L The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy. Dev Biol , 2006. [Full Text/Abstract]

4. Hennighausen L, Robinson GW Information networks in the mammary gland. Nat Rev Mol Cell Biol (6): 715-25, 2005. [Full Text/Abstract]

5. Evarts JL Rasweiler JJ 4th Behringer RR Hennighausen L Robinson GW A morphological and immunohistochemical comparison of mammary tissues from the short-tailed fruit bat (Carollia perspicillata) and the mouse. Biol Reprod (70): 1573-9, 2004. [Full Text/Abstract]

6. Nemade RV Bierie B Nozawa M Bry C Smith GH Vasioukhin V Fuchs E Hennighausen L Biogenesis and function of mouse mammary epithelium depends on the presence of functional alpha-catenin. Mech Dev (121): 91-9, 2004. [Full Text/Abstract]

7. Cui Y, Riedlinger G, Miyoshi K, Tang W, Li C, Deng CX, Robinson GW, Hennighausen L Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol (24): 8037-47, 2004. [Full Text/Abstract]

8. Bry C Maass K Miyoshi K Willecke K Ott T Robinson GW Hennighausen L Loss of connexin 26 in mammary epithelium during early but not during late pregnancy results in unscheduled apoptosis and impaired development. Dev Biol (267): 418-29, 2004. [Full Text/Abstract]

9. Zhao L Hart S Chen J Melenhorst JJ Bierie B Ernst M Stewart C Schaper F Heinrich PC Ullrich A Robinson GW Hennighausen L Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK. J Biol Chem , 2004. [Full Text/Abstract]

10. Renou JP Bierie B Miyoshi K Cui Y Djiane J Reichenstein M Shani M Hennighausen L Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin. Oncogene (22): 4594-610, 2003. [Full Text/Abstract]

11. Miyoshi K Shillingford JM Le Provost F Gounari F Bronson R von Boehmer H Taketo MM Cardiff RD Hennighausen L Khazaie K Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias. Proc Natl Acad Sci U S A (99): 219-24, 2002. [Full Text/Abstract]

12. Shillingford JM Miyoshi K Robinson GW Grimm SL Rosen JM Neubauer H Pfeffer K Hennighausen L Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium. Mol Endocrinol (16): 563-70, 2002. [Full Text/Abstract]

13. Miyoshi K Shillingford JM Smith GH Grimm SL Wagner KU Oka T Rosen JM Robinson GW Hennighausen L Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J Cell Biol (155): 531-42, 2001. [Full Text/Abstract]

14. Hennighausen L Robinson GW Signaling pathways in mammary gland development. Dev Cell (1): 467-75, 2001. [Full Text/Abstract]

15. Wagner KU Claudio E Rucker EB 3rd Riedlinger G Broussard C Schwartzberg PL Siebenlist U Hennighausen L Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. Development (127): 4949-58, 2000. [Full Text/Abstract]

16. Liu X Robinson GW Wagner KU Garrett L Wynshaw-Boris A Hennighausen L Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev (11): 179-86, 1997. [Full Text/Abstract]

17. Furth PA St Onge L Boger H Gruss P Gossen M Kistner A Bujard H Hennighausen L Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci U S A (91): 9302-6, 1994. [Full Text/Abstract]




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Page last updated: March 12, 2010

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