Marc L. Reitman, M.D., Ph.D.


Diabetes, Endocrinology, and Obesity Branch
DIABETES, ENDOCRINOLOGY, & OBESITY BRANCH
NIDDK, National Institutes of Health
Building 10-CRC , Room 5-5940
10 Center Dr.
Bethesda, MD 20814
Tel: 301-496-6442
Fax: 301-480-4518
Email: marc.reitman@nih.gov

Education / Previous Training and Experience:
B.S., Massachusetts Institute of Technology, 1977
M.D., Ph.D., Washington University in St. Louis, 1983


Research Statement:
Dr. Reitman returned to the NIDDK in early 2011 and will continue his long-standing interest in elucidating the mechanisms underlying energy homeostasis. The goal of this increased understanding is advancement in the treatment of diabetes and obesity. One focus is on using mouse models; particular interests include genetics and pharmacology, using mouse models to understand metabolic rate regulation and body temperature regulation, and drug treatments for obesity. Examples of research topics include uncoupling, lipodystrophy, leptin, and BRS-3 (bombesin receptor subtype-3). Another interest is in using the NIH Clinical Center’s Metabolic Clinical Research Unit, with its state of the art clinical facilities including room calorimeters. It is desired that knowledge obtained from mouse experimentation will generate hypotheses to be followed up in the clinical setting, and similarly, that clinical observations will spur investigations using mouse models.


Selected Publications:

1. Guan X-M, Metzger JM, Yang L, Raustad KA, Wang S-P, Spann SK, Kosinski JA, Yu H, Shearman LP, Faidley TD, Palyha O, Kan Y, Kelly TM, Sebhat I, Lin LS, Dragovic J, Lyons KA, Craw S, Nargund RP, Marsh DJ, Strack AM, Reitman ML: Anti-Obesity Effect of MK-5046, a Novel Bombesin Receptor Subtype-3 Agonist. J Pharmacol Exp Ther, 336:356-364, 2011 [Full Text/Abstract]

2. Reitman ML, Chu X, Cai X, Yabut J, Venkatasubramanian R, Zajic S, Stone JA, Ding Y, Witter R, Gibson C, Roupe K, Evers R, Wagner JA, Stoch A: Rifampin's Acute Inhibitory and Chronic Inductive Drug Interactions: Experimental and Model-Based Approaches to Drug-Drug Interaction Trial Design. Clin Pharmacol Ther, 89:234-242, 2011 [Full Text/Abstract]

3. Metzger JM, Gagen K, Raustad KA, Yang L, White A, Wang SP, Craw S, Liu P, Lanza T, Lin LS, Nargund RP, Guan XM, Strack AM, Reitman ML: Body Temperature as a Mouse Pharmacodynamic Response to Bombesin Receptor Subtype-3 Agonists and Other Potential Obesity Treatments. Am J Physiol Endocrinol Metab 299:E816-24, 2010 [Full Text/Abstract]

4. Guan XM, Chen H, Dobbelaar PH, Dong Y, Fong TM, Gagen K, Gorski J, He S, Howard AD, Jian T, Jiang M, Kan Y, Kelly TM, Kosinski J, Lin LS, Liu J, Marsh DJ, Metzger JM, Miller R, Nargund RP, Palyha O, Shearman L, Shen Z, Stearns R, Strack AM, Stribling S, Tang YS, Wang SP, White A, Yu H, Reitman ML: Regulation of Energy Homeostasis by Bombesin Receptor Subtype-3: Selective Receptor Agonists for the Treatment of Obesity. Cell Metab 11:101-112, 2010 [Full Text/Abstract]

5. Emilsson V, Thorleifsson G, Zhang B, Leonardson AS, Zink F, Zhu J, Carlson S, Helgason A, Walters GB, Gunnarsdottir S, Mouy M, Steinthorsdottir V, Eiriksdottir GH, Bjornsdottir G, Reynisdottir I, Gudbjartsson D, Helgadottir A, Jonasdottir A, Jonasdottir A, Styrkarsdottir U, Gretarsdottir S, Magnusson KP, Stefansson H, Fossdal R, Kristjansson K, Gislason HG, Stefansson T, Leifsson BG, Thorsteinsdottir U, Lamb JR, Gulcher JR, Reitman ML, Kong A, Schadt EE, Stefansson K: Genetics of gene expression and its effect on disease. Nature 452:423-428, 2008 [Full Text/Abstract]

6. Gavrilova O, Haluzik M, Matsusue K, Cutson JJ, Johnson L, Dietz KR, Nicol CJ, Vinson C, Gonzalez FJ, Reitman ML: Liver Peroxisome Proliferator-activated Receptor {gamma} Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass. J Biol Chem 278:34268-34276, 2003 [Full Text/Abstract]

7. Colombo C, Haluzik M, Cutson JJ, Dietz KR, Marcus-Samuels B, Vinson C, Gavrilova O, Reitman ML: Opposite Effects of Background Genotype on Muscle and Liver Insulin Sensitivity of Lipoatrophic Mice. Role of Triglyceride Clearance. J Biol Chem 278:3992-3999, 2003 [Full Text/Abstract]

8. Colombo C, Cutson JJ, Yamauchi T, Vinson C, Kadowaki T, Gavrilova O, Reitman ML: Transplantation of Adipose Tissue Lacking Leptin Is Unable to Reverse the Metabolic Abnormalities Associated With Lipoatrophy. Diabetes 51:2727-2733, 2002 [Full Text/Abstract]

9. Chao L, Marcus-Samuels B, Mason MM, Moitra J, Vinson C, Arioglu E, Gavrilova O, Reitman ML: Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones. J Clin Invest 106:1221-1228, 2000 [Full Text/Abstract]

10. Gong DW, Monemdjou S, Gavrilova O, Leon LR, Marcus-Samuels B, Chou CJ, Everett C, Kozak LP, Li C, Deng C, Harper ME, Reitman ML: Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J Biol Chem 275:16251-16257, 2000 [Full Text/Abstract]

11. Gavrilova O, Marcus-Samuels B, Graham D, Kim JK, Shulman GI, Castle AL, Vinson C, Eckhaus M, Reitman ML: Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J Clin Invest 105:271-278, 2000 [Full Text/Abstract]

12. Gavrilova O, Leon LR, Marcus-Samuels B, Mason MM, Castle AL, Refetoff S, Vinson C, Reitman ML: Torpor in mice is induced by both leptin-dependent and -independent mechanisms. Proc Natl Acad Sci U S A 96:14623-14628, 1999 [Full Text/Abstract]

13. Moitra J, Mason MM, Olive M, Krylov D, Gavrilova O, Marcus-Samuels B, Feigenbaum L, Lee E, Aoyama T, Eckhaus M, Reitman ML, Vinson C: Life without white fat: a transgenic mouse. Genes Dev 12:3168-3181, 1998 [Full Text/Abstract]

14. Reitman M, Lee E, Westphal H, Felsenfeld G: Site-independent expression of the chicken beta A-globin gene in transgenic mice. Nature 348:749-752, 1990 [Full Text/Abstract]

15. Reitman ML, Varki A, Kornfeld S: Fibroblasts from patients with I-cell disease and pseudo-Hurler polydystrophy are deficient in uridine 5'-diphosphate-N- acetylglucosamine: glycoprotein N-acetylglucosaminylphosphotransferase activity. J Clin Invest 67:1574-1579, 1981 [Full Text/Abstract]



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Page last updated: February 17, 2011

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